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prostate cancer selenium

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https://www.readbyqxmd.com/read/28319243/association-of-antioxidant-supplement-use-and-dementia-in-the-prevention-of-alzheimer-s-disease-by-vitamin-e-and-selenium-trial-preadvise
#1
Richard J Kryscio, Erin L Abner, Allison Caban-Holt, Mark Lovell, Phyllis Goodman, Amy K Darke, Monica Yee, John Crowley, Frederick A Schmitt
Importance: Oxidative stress is an established dementia pathway, but it is unknown if the use of antioxidant supplements can prevent dementia. Objective: To determine if antioxidant supplements (vitamin E or selenium) used alone or in combination can prevent dementia in asymptomatic older men. Design, Setting, and Participants: The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) trial began as a double-blind randomized clinical trial in May 2002, which transformed into a cohort study from September 2009 to May 2015...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28151881/serum-selenium-levels-and-prostate-cancer-risk-a-moose-compliant-meta-analysis
#2
Zhigang Cui, Dezhong Liu, Chun Liu, Gang Liu
Some observational studies have shown that elevated serum selenium levels are associated with reduced prostate cancer risk; however, not all published studies support these results. A literature search of PubMed, Embase, Medline, and the Cochrane Library up until September 2016 identified 17 studies suitable for further investigation. A meta-analysis was conducted on these studies to investigate the association between serum selenium levels and subsequent prostate cancer risk. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the overall OR of prostate cancer for the highest versus the lowest levels of serum selenium...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28102015/circulating-antioxidant-levels-and-risk-of-prostate-cancer-by-tmprss2-erg
#3
Rebecca E Graff, Gregory Judson, Thomas U Ahearn, Michelangelo Fiorentino, Massimo Loda, Edward L Giovannucci, Lorelei A Mucci, Andreas Pettersson
BACKGROUND: Few studies have considered etiological differences across molecular subtypes of prostate cancer, despite potential to improve opportunities for precision prevention of a disease for which modifiable risk factors have remained elusive. Factors that lead to DNA double-strand breaks, such as oxidative stress, may promote the formation of the TMPRSS2:ERG gene fusion in prostate cancer. We tested the hypothesis that increasing levels of pre-diagnostic circulating antioxidants, which may reduce oxidative stress, are associated with lower risk of developing TMPRSS2:ERG positive prostate cancer...
May 2017: Prostate
https://www.readbyqxmd.com/read/28076331/a-short-term-intervention-with-selenium-affects-expression-of-genes-implicated-in-the-epithelial-to-mesenchymal-transition-in-the-prostate
#4
Dieuwertje E G Kok, Lambertus A L M Kiemeney, Gerald W Verhaegh, Jack A Schalken, Emile N J T van Lin, J P Michiel Sedelaar, J Alfred Witjes, Christina A Hulsbergen-van de Kaa, Pieter van 't Veer, Ellen Kampman, Lydia A Afman
In parallel with the inconsistency in observational studies and chemoprevention trials, the mechanisms by which selenium affects prostate cancer risk have not been elucidated. We conducted a randomized, placebo-controlled trial to examine the effects of a short-term intervention with selenium on gene expression in non-malignant prostate tissue. Twenty-three men received 300 µg selenium per day in the form of selenized yeast (n=12) or a placebo (n=11) during 5 weeks. Prostate biopsies collected from the transition zone before and after intervention were analysed for 15 participants (n=8 selenium, n=7 placebo)...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27998216/biases-in-recommendations-for-and-acceptance-of-prostate-biopsy-significantly-affect-assessment-of-prostate-cancer-risk-factors-results-from-two-large-randomized-clinical-trials
#5
Catherine M Tangen, Phyllis J Goodman, Cathee Till, Jeannette M Schenk, M Scott Lucia, Ian M Thompson
Purpose To identify factors related to who undergoes a prostate biopsy in a screened population and to estimate the impact of biopsy verification on risk factor-prostate cancer associations. Patients and Methods Men who were screened regularly from the placebo arms of two large prostate cancer prevention trials (Prostate Cancer Prevention Trial [PCPT] and Selenium and Vitamin E Cancer Prevention Trial [SELECT]) were examined to define incident prostate cancer cohorts. Because PCPT had an end-of-study biopsy, prostate cancer cases were categorized by a preceding prostate-specific antigen/digital rectal examination prompt (yes/no) and noncases by biopsy-proven negative status (yes v no)...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27782038/the-effect-of-zinc-and-selenium-supplementation-mode-on-their-bioavailability-in-the-rat-prostate-should-administration-be-joint-or-separate
#6
Adam Daragó, Andrzej Sapota, Marzenna Nasiadek, Michał Klimczak, Anna Kilanowicz
It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver...
October 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27777235/colorectal-adenomas-in-participants-of-the-select-randomized-trial-of-selenium-and-vitamin-e-for-prostate-cancer-prevention
#7
Peter Lance, David S Alberts, Patricia A Thompson, Liane Fales, Fang Wang, Jerilyn San Jose, Elizabeth T Jacobs, Phyllis J Goodman, Amy K Darke, Monica Yee, Lori Minasian, Ian M Thompson, Denise J Roe
Selenium and vitamin E micronutrients have been advocated for the prevention of colorectal cancer. Colorectal adenoma occurrence was used as a surrogate for colorectal cancer in an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT) for prostate cancer prevention. The primary objective was to measure the effect of selenium (as selenomethionine) on colorectal adenomas occurrence, with the effect of vitamin E (as α-tocopherol) supplementation on colorectal adenoma occurrence considered as a secondary objective...
January 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/27677361/prostate-cancer-risk-related-to-foods-food-groups-macronutrients-and-micronutrients-derived-from-the-uk-dietary-cohort-consortium-food-diaries
#8
J A Lane, S E Oliver, P N Appleby, M A H Lentjes, P Emmett, D Kuh, A Stephen, E J Brunner, M J Shipley, F C Hamdy, D E Neal, J L Donovan, K-T Khaw, T J Key
BACKGROUND/OBJECTIVES: The influence of dietary factors remains controversial for screen-detected prostate cancer and inconclusive for clinically detected disease. We aimed to examine these associations using prospectively collected food diaries. SUBJECTS/METHODS: A total of 1,717 prostate cancer cases in middle-aged and older UK men were pooled from four prospective cohorts with clinically detected disease (n=663), with routine data follow-up (means 6.6-13.3 years) and a case-control study with screen-detected disease (n=1054), nested in a randomised trial of prostate cancer treatments (ISCTRN 20141297)...
February 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27519183/opportunities-and-challenges-in-incorporating-ancillary-studies-into-a-cancer-prevention-randomized-clinical-trial
#9
Phyllis J Goodman, Catherine M Tangen, Amy K Darke, Kathryn B Arnold, JoAnn Hartline, Monica Yee, Karen Anderson, Allison Caban-Holt, William G Christen, Patricia A Cassano, Peter Lance, Eric A Klein, John J Crowley, Lori M Minasian, Frank L Meyskens
BACKGROUND: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double-blind, placebo-controlled, prostate cancer prevention study funded by the National Cancer Institute and conducted by SWOG (Southwest Oncology Group). A total of 35,533 men were assigned randomly to one of four treatment groups (vitamin E + placebo, selenium + placebo, vitamin E + selenium, placebo + placebo). At the time of the trial's development, NIH had invested substantial resources in evaluating the potential benefits of these antioxidants...
August 12, 2016: Trials
https://www.readbyqxmd.com/read/27406859/tomato-based-randomized-controlled-trial-in-prostate-cancer-patients-effect-on-psa
#10
Ingvild Paur, Wolfgang Lilleby, Siv Kjølsrud Bøhn, Erik Hulander, Willibrord Klein, Ljiljana Vlatkovic, Karol Axcrona, Nils Bolstad, Trine Bjøro, Petter Laake, Kristin A Taskén, Aud Svindland, Lars Magne Eri, Bjørn Brennhovd, Monica H Carlsen, Sophie D Fosså, Sigbjørn S Smeland, Anette S Karlsen, Rune Blomhoff
BACKGROUND & AIMS: The effect of lycopene-containing foods in prostate cancer development remains undetermined. We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen (PSA) in prostate cancer patients. METHODS: Prior to their curative treatment, 79 patients with prostate cancer were randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks...
June 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27385803/selenium-and-prostate-cancer-analysis-of-individual-participant-data-from-fifteen-prospective-studies
#11
Naomi E Allen, Ruth C Travis, Paul N Appleby, Demetrius Albanes, Matt J Barnett, Amanda Black, H Bas Bueno-de-Mesquita, Mélanie Deschasaux, Pilar Galan, Gary E Goodman, Phyllis J Goodman, Marc J Gunter, Markku Heliövaara, Kathy J Helzlsouer, Brian E Henderson, Serge Hercberg, Paul Knekt, Laurence N Kolonel, Christina Lasheras, Jakob Linseisen, E Jeffrey Metter, Marian L Neuhouser, Anja Olsen, Valeria Pala, Elizabeth A Platz, Harri Rissanen, Mary E Reid, Jeannette M Schenk, Meir J Stampfer, Pär Stattin, Catherine M Tangen, Mathilde Touvier, Antonia Trichopoulou, Piet A van den Brandt, Timothy J Key
BACKGROUND: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. METHODS: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk...
November 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27341379/synthesis-and-antitumor-activity-of-selenium-containing-quinone-based-triazoles-possessing-two-redox-centres-and-their%C3%A2-mechanistic-insights
#12
Eduardo H G da Cruz, Molly A Silvers, Guilherme A M Jardim, Jarbas M Resende, Bruno C Cavalcanti, Igor S Bomfim, Claudia Pessoa, Carlos A de Simone, Giancarlo V Botteselle, Antonio L Braga, Divya K Nair, Irishi N N Namboothiri, David A Boothman, Eufrânio N da Silva Júnior
UNLABELLED: Selenium-containing quinone-based 1,2,3-triazoles were synthesized using click chemistry, the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition, and evaluated against six types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), PC3 (human prostate cells), SF295 (human glioblastoma cells), MDA-MB-435 (melanoma cells) and OVCAR-8 (human ovarian carcinoma cells). Some compounds showed IC50 values < 0.3 μM. The cytotoxic potential of the quinones evaluated was also assayed using non-tumor cells, exemplified by peripheral blood mononuclear (PBMC), V79 and L929 cells...
October 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27197287/selenium-or-vitamin-e-related-gene-variants-interaction-with-supplementation-and-risk-of-high-grade-prostate-cancer-in-select
#13
June M Chan, Amy K Darke, Kathryn L Penney, Catherine M Tangen, Phyllis J Goodman, Gwo-Shu Mary Lee, Tong Sun, Sam Peisch, Alex M Tinianow, James M Rae, Eric A Klein, Ian M Thompson, Philip W Kantoff, Lorelei A Mucci
BACKGROUND: Epidemiologic studies and secondary analyses of randomized trials supported the hypothesis that selenium and vitamin E lower prostate cancer risk. However, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed no benefit of either supplement. Genetic variants involved in selenium or vitamin E metabolism or transport may underlie the complex associations of selenium and vitamin E. METHODS: We undertook a case-cohort study of SELECT participants randomized to placebo, selenium, or vitamin E...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27186192/the-role-of-micronutrients-in-the-risk-of-urinary-tract-cancer
#14
Tomasz Golabek, Jakub Bukowczan, Robert Sobczynski, Jaroslaw Leszczyszyn, Piotr L Chlosta
Prostate, bladder and kidney cancers remain the most common urological malignancies worldwide, and the prevention and treatment of these diseases pose a challenge to clinicians. In recent decades, many studies have been conducted to assess the association between supplementation with selected vitamins and elements and urinary tract tumour initiation and development. Here, we review the relationship between vitamins A, B, D, and E, in addition to calcium, selenium, and zinc, and the risk of developing prostate, kidney and bladder cancer...
April 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27099271/is-there-a-future-for-chemoprevention-of-prostate-cancer
#15
Maarten C Bosland
The outcome of the Selenium and Vitamin E Cancer Prevention Trial, demonstrating harm and no preventive activity of selenomethionine and α-tocopherol for prostate cancer, and the lack of approval by the FDA for the use of 5α-reductase inhibitors to prevent prostate cancer have cast doubt about the future of chemoprevention of prostate cancer. This article attempts to critically assess whether the notion that chemoprevention of prostate cancer has no future is warranted. Risk of prostate cancer is modifiable and chemoprevention of prostate cancer, particularly fatal/lethal cancer, is both needed and possible...
August 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/26971676/selenium-status-and-risk-of-prostate-cancer-in-a-danish-population
#16
Malene Outzen, Anne Tjønneland, Erik H Larsen, Søren Friis, Signe B Larsen, Jane Christensen, Kim Overvad, Anja Olsen
Low-Se status may be associated with a higher risk of notably advanced prostate cancer. In a Danish population with a relatively low Se intake, we investigated the association between pre-diagnostic Se status and (1) the risk of total, advanced and high-grade prostate cancer and (2) all-cause and prostate cancer-specific mortality among men with prostate cancer. Within the Danish 'Diet, Cancer and Health' cohort, including 27 179 men, we identified 784 cases with incident prostate cancer through 2007. Each case was risk set-matched to one control...
May 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26957512/prostate-cancer-prevention-concepts-and-clinical-trials
#17
REVIEW
Zachary Hamilton, J Kellogg Parsons
Prevention is an important treatment strategy for diminishing prostate cancer morbidity and mortality and is applicable to both early- and late-stage disease. There are three basic classifications of cancer prevention: primary (prevention of incident disease), secondary (identification and treatment of preclinical disease), and tertiary (prevention of progression or recurrence). Based on level I evidence, 5-alpha reductase inhibitors (5-ARIs) should be considered in selected men to prevent incident prostate cancer...
April 2016: Current Urology Reports
https://www.readbyqxmd.com/read/26922233/novel-seleno-and-thio-urea-derivatives-with-potent-in-vitro-activities-against-several-cancer-cell-lines
#18
Verónica Alcolea, Daniel Plano, Deepkamal N Karelia, Juan Antonio Palop, Shantu Amin, Carmen Sanmartín, Arun K Sharma
A series of novel selenourea derivatives and corresponding thiourea analogs were synthesized and tested against a panel of six human cancer cell lines: melanoma (1205Lu), lung carcinoma (A549), prostatic carcinoma (DU145), colorectal carcinoma (HCT116), pancreatic epithelioid carcinoma (PANC-1) and pancreatic adenocarcinoma (BxPC3). In general, we found that the selenium-containing derivatives were more potent than their isosteric sulfur analogs. Four selenourea derivatives (1e, 1f, 1g and 1i) showed IC50 values below 10 μM in all of tested cell lines at 72 h...
May 4, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26887708/re-difference-in-association-of-obesity-with-prostate-cancer-risk-between-us-african-american-and-non-hispanic-white-men-in-the-selenium-and-vitamin-e-cancer-prevention-trial-select
#19
COMMENT
https://www.readbyqxmd.com/read/26855488/status-and-interrelationship-of-zinc-copper-iron-calcium-and-selenium-in-prostate-cancer
#20
Bhupendra Pal Singh, Shailendra Dwivedi, Urmila Dhakad, Ramesh Chandra Murthy, Vimal Kumar Choubey, Apul Goel, Satya Narayan Sankhwar
Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/Mann-Whitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations...
March 2016: Indian Journal of Clinical Biochemistry: IJCB
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