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https://www.readbyqxmd.com/read/29665852/a-novel-method-for-demonstrating-cold-agglutinin-disease-a-case-report
#1
Thomas A Vo, Zack Oakey, Yasir A Khan, Donald S Minckler
BACKGROUND: Cold agglutinin disease is a rare disorder characterized by an autoimmune hemolytic anemia occurring at low temperatures. Physical examination findings, often limited to acrocyanosis, are combined with a thermal amplitude test to help establish the diagnosis. Thermal amplitude testing determines the highest temperature at which the cold agglutination will occur and is an important parameter in diagnosing cold agglutinin disease. CASE PRESENTATION: Here we describe a 57-year-old white man of German and Nicaraguan descent with known chronic cold agglutinin disease who presented to our ophthalmology clinic for evaluation of a cataract...
April 18, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29665318/assessment-of-vestibular-function-in-patients-with-chronic-middle-ear-disease-using-the-vhit-and-vemp-test
#2
J S Sandhu, M Yung, J Parker-George, B Kearney, J Ray
It is widely accepted that middle ear pathology can cause dizziness and imbalance, however this has been a challenging area to investigate, as the bi-thermal caloric test is difficult to interpret in this cohort. Recently vestibular tests that bypass the middle ear have been developed. These are the Video Head Impulse Test (vHIT) and the Bone Conduction Vestibular Evoked Myogenic Potentials (BC-VEMPs). We have successfully carried out pre-operative vHIT and BC-VEMPs on 20 patients awaiting surgery for middle ear pathologies and have shown that complete testing can be done in less than 30 minutes...
April 17, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29657246/effects-of-three-forms-of-local-anesthesia-on-perioperative-fentanyl-induced-hyperalgesia
#3
Lu Chang, Fang Ye, Quehua Luo, Zewen Wang, Yimin Wang, Zhengyuan Xia, Haihua Shu
Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar incision after the second injection or they received pre-incision LIA and sciatic nerve block (SNB) or post-incision LIA with levobupivacaine (0...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29643327/comparison-of-effects-of-vessel-sealing-devices-and-conventional-hemorrhoidectomy-on-postoperative-pain-and-quality-of-life
#4
Murat Kendirci, İbrahim Tayfun Şahiner, Yeliz Şahiner, Güven Güney
BACKGROUND The aim of this study was to investigate the early and late results of use of LigaSure, Harmonic Scalpel, and conventional hemorrhoidectomy in hemorrhoidectomy, to determine the least painful method, and to investigate the relationship between pain perception and personal differences in hemorrhoid bundles. MATERIAL AND METHODS Ninety patients undergoing hemorrhoidectomy between 2014 and 2017 were retrospectively evaluated. We investigated the duration of hospitalization and the presence of bleeding, incontinence, perianal wetness, urinary retention, stenosis, and recurrence during follow-up after surgery...
April 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29626695/multi-functional-electrospun-antibacterial-core-shell-nanofibrous-membranes-for-prolonged-prevention-of-post-surgical-tendon-adhesion-and-inflammation
#5
K T Shalumon, Chialin Sheu, Chih-Hao Chen, Shih-Heng Chen, Gils Jose, Chang-Yi Kuo, Jyh-Ping Chen
The possibility of endowing an electrospun anti-adhesive barrier membrane with multi-functionality, such as lubrication, prevention of fibroblast attachment and anti-infection and anti-inflammation properties, is highly desirable for the management of post-surgical tendon adhesion. To this end, we fabricated core-shell nanofibrous membranes (CSNMs) with embedded silver nanoparticles (Ag NPs) in the poly(ethylene glycol) (PEG)/poly(caprolactone) (PCL) shell and hyaluronic acid (HA)/ibuprofen in the core. HA imparted a lubrication effect for smooth tendon gliding and reduced fibroblast attachment, while Ag NPs and ibuprofen functioned as anti-infection and anti-inflammation agents, respectively...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29620177/gardenoside-combined-with-ozone-inhibits-the-expression-of-p2x3-and-p2x7-purine-receptors-in-rats-with-sciatic-nerve-injury
#6
Mingdong Yu, Yong Zhao, Xiaoxia Zhang
Neuropathic pain is a severe health problem for which there is a lack of effective therapy. Ozone and Gardenia fruits have been used separately in pain relief for many years; however, their underlying mechanisms remain unclear. To investigate the pain‑relieving effects of combined ozone and Gardenia, a chronic constriction sciatic nerve injury (CCI) rat model was constructed and treated with ozone and gardenoside (Ozo&Gar), which is a compound found in Gardenia fruits. A total of 70 rats were randomly divided into five groups: Control (Ctrl), Ctrl + Ozo&Gar, Sham, CCI, and CCI + Ozo&Gar...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620141/jmjd6-exerts-function-in-neuropathic-pain-by-regulating-nf%C3%A2-%C3%AE%C2%BAb-following-peripheral-nerve-injury-in-rats
#7
Cen Wen, Mengyuan Xu, Cheng Mo, Zhigang Cheng, Qulian Guo, Xiaoyan Zhu
Treatment of neuropathic pain (NPP) continues to be a major challenge, and the underlying mechanisms remain to be elucidated. Previous studies have demonstrated that histone methylation is important in synaptic plasticity of the nervous system and may affect nuclear factor‑κB (NF‑κB) signaling through epigenetic mechanisms. The present study aimed to investigate the role of Jumonji C domain 6 (JMJD6), a histone demethylase, in a chronic constriction injury (CCI) model of NPP. On the third day post‑CCI surgery, a JMJD6 overexpressing lentiviral vector (LV‑JMJD6) was intrathecally injected in the rats...
April 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29619789/inadvertent-thermal-injury-following-knee-arthroscopic-surgery-in-a-pediatric-patient
#8
Daegyu Kwon, Byung-Gun Kim, Chunwoo Yang, Jonghun Won, Yoonjung Kim
Inadvertent thermal injury can occur in pediatric patients under general anesthesia during knee arthroscopic surgery. Here, we report the case of a 10-year-old boy who underwent knee arthroscopic surgery under general anesthesia. After the surgery, he complained of pain in the left lower part of his chin and was diagnosed as having a thermal burn. At three-month follow-up, he recovered without any abnormalities except mild hypertrophy of the wound area. Although rare, arthroscopic surgery has the potential to cause thermal injury from the light source...
April 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29608947/microencapsulated-schwann-cell-transplantation-inhibits-p2x2-3-receptors-overexpression-in-a-sciatic-nerve-injury-rat-model-with-neuropathic-pain
#9
Ya-Ling Zhang, Yi-Guo Liu, De-Jian Chen, Bao-Lin Yang, Tao-Tao Liu, Jia-Juan Li, Xiu-Qi Wang, Hao-Tian Rose Li, Zeng-Xu Liu
Transplantation of Schwann cells (SCs) can promote axonal regeneration and formation of the myelin sheath, reduce inflammation, and promote repair to the damaged nerve. Our previous studies have shown that transplantation of free or micro-encapsulated olfactory ensheathing cells can relieve neuropathic pain. There are no related reports regarding whether the transplantation of micro-encapsulated SCs can alleviate neuropathic pain mediated by P2 × 2/3 receptors. In the present study, we micro-encapsulated SCs in alginic acid and transplanted them into the region surrounding the injured sciatic nerve in the rat model of chronic constriction injury (CCI)...
March 30, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29604548/non-ablative-er-yag-laser-therapy-effect-on-stress-urinary-incontinence-related-to-quality-of-life-and-sexual-function-a-randomized-controlled-trial
#10
Mija Blaganje, Darija Šćepanović, Lidija Žgur, Ivan Verdenik, Franja Pajk, Adolf Lukanović
OBJECTIVE: Stress urinary incontinence (SUI) is a common complaint in women after childbirth. It affects their quality of life and sexual satisfaction and is one of the major reasons for gynaecological surgery. There is a need for effective non-invasive treatment alternatives. The aim of this study was to evaluate the efficacy and safety of non-ablative Er:YAG laser therapy in the treatment of SUI and improvement of sexual gratification in parous women. STUDY DESIGN: 114 premenopausal parous women with SUI were randomized in two groups of 57 women; a laser intervention group and sham group...
March 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29602604/hair-sparing-does-not-compromise-real-time-magnetic-resonance-imaging-guided-stereotactic-laser-fiber-placement-for-temporal-lobe-epilepsy
#11
Shikha Singh, Kevin K Kumar, Matthew J Rabon, Dana Dolce, Casey H Halpern
Pre-operative scalp shaving is conventionally thought to simplify postoperative cranial wound care, lower the rate of wound infections, and ease optimal incision localization. Over the past few decades, some neurosurgeons have refrained from scalp shaving in order to improve patient satisfaction with brain surgery. However, this hair-sparing approach has not yet been explored in the growing field of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT). This study investigated the initial impact of a no-shave technique on post-operative wound infection rate as well as on entry and target accuracy in MRgLITT for mesial temporal epilepsy...
March 27, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29600828/an-electrical-plasma-dissection-tool-for-surgical-treatment-of-chronic-ulcers-results-of-a-prospective-randomised-trial
#12
Giovanni F Marangi, Tiziano Pallara, Daniela Lamberti, Eleonora Perrella, Raffaele Serra, Francesco Stilo, Giovanni De Caridi, Andrea Onetti Muda, Paolo Persichetti
Cutaneous ulceration is a difficult medical problem and a major source of morbidity for patients. In the surgical treatment of ulcers, debridement is the first step, and it can be carried out using several surgical tools. Recently, new surgical devices have emerged using plasma-mediated electrical discharges with a lower peak temperature. A prospective single-blind trial was conducted on chronic ulcers not responsive to common non-surgical management. Patients were randomly separated into 2 groups: Group A received surgical debridement with conventional electrocautery, and Group B received surgical debridement using the plasma-mediated device...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29594001/urinary-ascites-in-late-onset-of-bladder-injury-post-laparoscopic-hysterectomy
#13
Josette C Dawkins, Gregory K Lewis, Benjamin Christensen, Morris Wortman
Urinary tract injuries are unfortunate complications of pelvic surgery. With the increasing popularity of minimally invasive surgery, a thorough understanding of electrosurgical instrumentation and their thermal spread is important to reduce patient injuries. The index patient was a 50 year old woman who underwent a supracervical hysterectomy 5 years prior to her presentation with pelvic pain and dysuria. When her symptoms failed to improve despite antibiotic and analgesic therapy, an abdominal CT scan revealed an ovarian cyst and ascites...
October 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29592784/the-analgesic-effect-of-early-hyperbaric-oxygen-treatment-in-chronic-constriction-injury-rats-and-its-influence-on-nnos-and-inos-expression-and-inflammatory-factor-production
#14
Yuanyuan Ding, Peng Yao, Tao Hong, Hongxi Li, Yongqiang Zhu, Zhenkai Han, Guangyu Zhou
Objective To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI) rats, and to analyze the influence of HBO on the expression of neuronal nitric oxide synthase and inducible nitric oxide synthase and on the levels of inflammatory factors. Methods Rats were assigned into three groups randomly: sham, CCI, and HBO groups. The CCI rat model was established, and HBO treatment at 2.5 ATA (60 min) was given one day after surgery, lasting for five consecutive days...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29582944/-percutaneous-treatment-of-small-renal-tumors-by-thermal-ablation
#15
Amitay Lorber, Nahum S Goldberg, Ofer N Gofrit, Dov Pode, Vladimir Yutkin, Ilan Gielchinsky, Mordechai Duvdevani, Ezekiel H Landau, Guy Hidas, Liat Apelbaum
INTRODUCTION: Kidney cancer accounts for approximately 2-3 % of all types of cancers. Renal tumors prevalence and especially the prevalence of small renal tumors, is on the rise. About half of the tumors currently diagnosed are smaller than 4 cm. Minimally invasive methods of radiofrequency ablation technology were recently developed for the treatment of small renal tumors and are characterized by reducing the surgical and anesthetic risk. The ablation is performed with a percutaneous approach guided by ultrasound, CT or MRI...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29580853/fem-simulation-of-em-field-effect-on-body-tissues-with-bio-nanofluid-blood-with-nanoparticles-for-nanoparticle-mediated-hyperthermia
#16
Rangoli Goyal, Rama Bhargava
The study of temperature profiles and heat transport within the human body when subjected to electromagnetic waves is crucial for development and improvement of radiofrequency hyperthermia treatments. These treatments being minimally invasive can be a better alternative over surgery and chemotherapy for treatment of cancer. Nanoparticle-mediated hyperthermia for cancer therapy is a growing area of cancer nanomedicine because of the potential for localized and targeted destruction of cancer cells. This treatment is dependent on many factors, including thermal conductivity of bio-nanofluid, volume fraction of nanoparticles,excitation wavelength and power and metabolic heat generation...
March 23, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29576123/role-of-spinal-cyclooxygenase-2-and-prostaglandin-e2-in-fentanyl-induced-hyperalgesia-in-rats
#17
Q B Li, L Chang, F Ye, Q H Luo, Y X Tao, H H Shu
BACKGROUND: Accumulated evidence suggests that spinal cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) may be implicated in the development of opioid-induced hyperalgesia. METHODS: Rats received subcutaneous fentanyl injections at different doses (20-80 μg kg-1 ), four separate times at 15-min intervals. Some rats only received fentanyl (60 μg kg-1  × 4 doses) with or without surgical incision. Fentanyl-induced hyperalgesia was evaluated via a tail-pressure or paw-withdrawal test...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29575882/evaluation-of-the-frequency-of-childhood-hospitalization-due-to-thermal-injuries-in-the-provincial-polyclinical-hospital-in-toru%C3%A5-poland-2007-2011
#18
Ewa Barczykowska, Małgorzata Cyran, Aneta Zreda-Pikies, Małgorzata Kowalczyk, Robert Ślusarz, Andrzej Kurylak
INTRODUCTION: Burns constitute the most common and severe injuries suffered in childhood. OBJECTIVE: The study was aimed at providing a retrospective analysis of the etiology, location, extent and depth of burns, as well as treatment methods and length of hospital stay. MATERIAL AND METHODS: A retrospective analysis of 508 cases of children treated due to a thermal injury between 1 January 2007 31 December 2011 was conducted at the Department of Paediatrics, Urology and Paediatric Surgery, Children's Hospital, L...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29573222/concise-review-altered-versus-unaltered-amniotic-membrane-as-a-substrate-for-limbal-epithelial-cells
#19
REVIEW
Tor Paaske Utheim, Øygunn Aass Utheim, Panagiotis Salvanos, Catherine J Jackson, Stefan Schrader, Gerd Geerling, Amer Sehic
Limbal stem cell deficiency (LSCD) can result from a variety of corneal disorders, including chemical and thermal burns, infections, and autoimmune diseases. The symptoms of LSCD may include irritation, epiphora, blepharospasms, photophobia, pain, and decreased vision. There are a number of treatment options, ranging from nonsurgical treatments for mild LSCD to various forms of surgery that involve different cell types cultured on various substrates. Ex vivo expansion of limbal epithelial cells (LEC) involves the culture of LEC harvested either from the patient, a living relative, or a cadaver on a substrate in the laboratory...
March 23, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29567631/interventional-radiology-role-in-the-treatment-of-sarcomas
#20
REVIEW
Thierry de Baere, Lambros Tselikas, Guillaume Gravel, Antoine Hakime, Frederic Deschamps, Charles Honoré, Olivier Mir, Axel Lecesne
In bone and soft tissue sarcomas (STS), surgery was to the only local curative treatment, but recently, radiation therapy and interventional radiology has evolved to potentially curative treatment, namely in small size tumours. Indication for local treatment in STS needs validation in multidisciplinary team. Most will agree on local treatment for single metastatic location in a well-controlled disease and for no local treatment in a rapidly evolving multi-metastatic disease. The challenge is in patients who are in between, for whom benefit of disease control on overall survival should be evaluated...
March 19, 2018: European Journal of Cancer
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