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https://www.readbyqxmd.com/read/28339077/paeoniflorin-attenuates-the-neuroinflammatory-response-in-a-rat-model-of-chronic-constriction-injury
#1
Jianyu Zhou, Jingxia Wang, Wei Li, Chenglong Wang, Li Wu, Jianjun Zhang
Neuropathic pain remains the most frequent cause of suffering and disability worldwide. Paeoniflorin (PF), a water‑soluble monoterpene glycoside extracted from the roots of Paeonia lactiflora Pall, has a wide range of pharmacological functions. Although the neuroprotective effect of PF has been reported in animal models of neuropathology, no systematic investigation has reported on the analgesic properties of PF in neuropathic pain. The aim of the present study was to investigate whether PF can alleviate neuropathic pain and to examine its possible mechanism...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28328655/vascularized-composite-allotransplantation-an-emerging-concept-for-burn-reconstruction
#2
Zhi Yang Ng, Alexandre G Lellouch, Tessa Drijkoningen, Irene A Chang, David H Sachs, Curtis L Cetrulo
Vascularized composite allotransplantation (VCA) has demonstrated utility in the reconstruction of extensive soft-tissue defects following severe burns. However, pre-VCA events such as multiple transfusions, previous transplantation and pregnancies, the use of skin allografts, and mechanical support devices may result in sensitization and ultimately exclude a burn patient, who may benefit most through VCA, from a hand or face transplant. The authors sought to identify the immunologic challenges involved. All reported VCA cases up to July 2016 were reviewed...
March 15, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28324881/optic-radiation-tractography-and-visual-field-deficits-in-laser-interstitial-thermal-therapy-for-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#3
Dali Yin, John A Thompson, Cornelia Drees, Steven G Ojemann, Lidia Nagae, Victoria S Pelak, Aviva Abosch
BACKGROUND/AIMS: Laser interstitial thermal therapy (LITT) has become an alternative to open-resective surgery for refractory mesial temporal lobe epilepsy (MTLE). Occurrence of visual field defects (VFDs) following open surgery for MTLE is reported at 52-100%. We examined the rate of VFDs following LITT for amygdalohippocampectomy (AHE) and correlated the occurrence of VFDs with damage to the optic radiations, assessed by diffusion tensor tractography (DTI). METHODS: We performed a retrospective analysis of 5 patients who underwent LITT-AHE for medically refractory MTLE...
March 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28318494/the-role-of-the-irreversible-electroporation-in-the-hepato-pancreatico-biliary-surgery
#4
Patricia Sánchez-Velázquez, Pierre-Alain Clavien
Irreversible electroporation is a novel technique growing in popularity over the last years among the ablative modalities. Its unique action mechanism produces irreversible nanopores in the membrane of the cell leading to apoptosis; therefore irreversible electroporation can be used to ablate substantial volumes of tissue without the undesirable thermal effects as the "heat sink effect". Moreover the extracellular matrix is left unperturbed, thus sparing the structural architecture of surrounding structures such as bile ducts and blood vessels...
March 16, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28315984/thermomechanical-method-for-cement-extraction-in-revision-arthroplasty
#5
M Ghanem, A Koenig, F Dehn, C-E Heyde, C Josten
BACKGROUND: In joint revision surgery, bone cement extraction remains a major challenge which even today has not seen a satisfactory solution yet. We studied in an experimental setting the impact of heat sources on the mechanical properties and microstructure of bone cement and determined the glass transition temperature (T G) of bone cement. As a result, it would be possible to establish a thermomechanical method which makes use of the structural and material-specific property changes inherent in bone cement at elevated temperatures...
March 18, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28314072/cordless-ultrasonic-dissector-versus-advanced-bipolar-vessel-sealing-device-for-laparoscopic-ovariectomy-in-dogs
#6
Anneleen L Spillebeen, Sara S D S Janssens, Rachel E Thomas, Jolle Kirpensteijn, Sebastiaan A van Nimwegen
OBJECTIVE: To compare Sonicision cordless ultrasonic dissector (SCUD) to LigaSure vessel sealing device (LVSD) for laparoscopic ovariectomy (Lap OVE) in dogs. STUDY DESIGN: Randomized, paired prospective clinical trial. ANIMALS: Client-owned dogs (n = 22) presented for elective Lap OVE. METHODS: Dogs were randomly assigned to one of two protocols: protocol 1 required the left ovary resected using SCUD and the right ovary using LVSD; protocol 2 required the left ovary resected using LVSD and the right ovary using SCUD...
March 17, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28295825/effectiveness-of-manual-therapy-versus-surgery-in-pain-processing-due-to-carpal-tunnel-syndrome-a-randomized-clinical-trial
#7
C Fernández-de-Las-Peñas, J Cleland, M Palacios-Ceña, S Fuensalida-Novo, C Alonso-Blanco, J A Pareja, F Alburquerque-Sendín
BACKGROUND: People with carpal tunnel syndrome (CTS) exhibit widespread pressure pain and thermal pain hypersensitivity as a manifestation of central sensitization. The aim of our study was to compare the effectiveness of manual therapy versus surgery for improving pain and nociceptive gain processing in people with CTS. METHODS: The trial was conducted at a local regional Hospital in Madrid, Spain from August 2014 to February 2015. In this randomized parallel-group, blinded, clinical trial, 100 women with CTS were randomly allocated to either manual therapy (n = 50), who received three sessions (once/week) of manual therapies including desensitization manoeuvres of the central nervous system, or surgical intervention (n = 50) group...
March 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28284576/hemostasis-in-endoscopic-endonasal-skull-base-surgery-using-the-aquamantys-bipolar-sealer-technical-note
#8
Richard Bram, Susan Fiore, Daryl McHugh, Ghassan J Samara, Raphael P Davis
BACKGROUND: A major challenge during endoscopic transsphenoidal surgery is adequate intraoperative hemostasis. The Aquamantys® is a relatively new bipolar sealing device which uses radiofrequency energy and saline. This promotes hemostasis while decreasing charring and thermal spread. In this paper, we describe our experience with the Aquamantys® Mini EVS 3.4 Epidural Vein Sealer Bipolar Electrocautery System (Medtronic Advanced Energy, Portsmouth, NH, USA) during endoscopic surgery for tumors of the skull base with particular attention to ergonomic benefits and technical nuances...
March 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28279757/comparing-two-uterine-manipulators-at-total-laparoscopic-hysterectomy-a-randomized-controlled-trial
#9
Heinrich Husslein, Helena Frecker, Eliane M Shore, Guylaine Lefebvre, Eleanor Latta, Eliana Montanari, Abheha Satkunaratnam
STUDY OBJECTIVE: To compare two different types of uterine manipulators (i.e., tight fitting vs. loose fitting) used for total laparoscopic hysterectomy (TLH). DESIGN: Randomized controlled trial. Primary endpoints were time for colpotomy, time from skin incision to detachment of the uterus and histological assessment of thermal damage to the vagina. DESIGN: Classification: Canadian Task Force Classification I SETTING: University teaching hospital...
March 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28276751/development-of-a-laser-controlled-device-to-modulate-intraocular-pressure
#10
REVIEW
Jeffrey L Olson, Ramanath Bhandari, Sergio Groman-Lupa, Daniela Santos-Cantu, Raul Velez-Montoya
The current standard of treatment for glaucoma is trabeculectomy. The use of glaucoma drainage devices has increased in recent years since its efficacy and safety was established as it provides an alternative surgical option. A downfall of these devices is the lack of proper flow rate control. Areas covered: In this paper we describe a glaucoma drainage device regulator that has already been protoyped and undergone initial testing. It consists of an implantable device with a semipermeable membrane that is used during glaucoma surgery and can be opened with either thermal or photodisruptive laser to adjust the amount of flow precisely and non-invasively, addressing the current difficulties of glaucoma surgeries...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28272673/comparison-of-three-different-new-bipolar-energy-modalities-and-classic-bipolar-in-vivo-for-tissue-thermal-spread
#11
Melike Demir Çaltekin, Serpil Aydoğmuş, Serenat Eriş Yalçin, Emine Demirel, Fulya Cakalağaoğlu Unay, Pelin Özün Özbay, Aslı Özdemir, Yakup Yalçin, Sefa Kelekçi
OBJECTIVE: The aim of this study was to compare three different new bipolar energy modalities and classic bipolar in vivo for tissue thermal spread. MATERIAL AND METHOD: This prospective, randomized, single-blind study was conducted between Septemsber 2012 and July 2013. Eighteen patients aged 40-65 years undergoing hysterectomy and bilateral salpingectomy for benign etiology were included in the study. Before the hysterectomy operation began, it was marked nearly distal third cm started from uterine corn and proximal close third cm started from fimbrial bottoms by visualizing both fallopian tubes...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28271298/post-operative-orofacial-pain-temporomandibular-dysfunction-and-trigeminal-sensitivity-after-recent-pterional-craniotomy-preliminary-study
#12
Thiago Medina Brazoloto, Silvia Regina Dowgan Tesseroli de Siqueira, Pedro Augusto Sampaio Rocha-Filho, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira, José Tadeu Tesseroli de Siqueira
BACKGROUND: Surgical trauma at the temporalis muscle is a potential cause of post-craniotomy headache and temporomandibular disorders (TMD). The aim of this study was to evaluate the prevalence of pain, masticatory dysfunction and trigeminal somatosensory abnormalities in patients who acquired aneurysms following pterional craniotomy. METHODS: Fifteen patients were evaluated before and after the surgical procedure by a trained dentist. The evaluation consisted of the (1) research diagnostic criteria for TMD, (2) a standardized orofacial pain questionnaire and (3) a systematic protocol for quantitative sensory testing (QST) for the trigeminal nerve...
March 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28257392/prehospital-hypertonic-fluid-resuscitation-for-trauma-patients-a-systematic-review-and-meta-analysis
#13
Claire de Crescenzo, Farzam Gorouhi, Edgardo S Salcedo, Joseph M Galante
BACKGROUND: Prehospital assessment of a patient's circulation status and appropriate resuscitation with intravenous fluids plays a critical role in patients with obvious hemorrhage or systolic blood pressure below 90 mmHg. OBJECTIVES: We assessed the efficacy and safety of prehospital administration of crystalloids, or colloids to improve the survival rate of trauma patients with acceptable safety profile. DATA SOURCES: We searched SCOPUS, Embase, TRIP database, Cochrane Central Register of Controlled Trials, Ovid MEDLINE, and PubMed as per search protocol from 1 January 1900 to 12 February 2015...
March 2, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28256701/treatment-of-multiple-synchronous-misdiagnosed-renal-cell-cancers-in-a-young-patient-affected-by-a-de-novo-von-hippel-lindau-syndrome
#14
Marco Allasia, Antonino Battaglia, Barbara Pasini, Carlo Gazzera, Marco Calandri, Andrea Bosio, Paolo Gontero, Paolo Destefanis
INTRODUCTION: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome occurring in one out of 36,000 live births. Diagnosis could be a challenge in patients with no familial VHL history. Renal cancer (RCC) represents one of the most important manifestations. RCC is usually recurrent and multifocal. Actually treating RCC in VHL patients represent a clinical dilemma: the oncological outcomes must be balanced against renal function preservation. CASE PRESENTATION: A young man with a negative familial history was referred to our department with seven misdiagnosed renal masses...
February 28, 2017: Urologia
https://www.readbyqxmd.com/read/28250344/a-plga-peg-plga-thermosensitive-gel-enabling-sustained-delivery-of-ropivacaine-hydrochloride-for-postoperative-pain-relief
#15
Xudong Fu, Huilin Zeng, Jiaping Guo, Hong Liu, Zhen Shi, Huhai Chen, Dezong Li, Xiangyang Xie, Changchun Kuang
Postoperative pain is a complex physiological response to disease and tissue injury. Moderate-to-severe pain typically occurs within 48 h after surgery. Amino amide local anesthetics are widely applied to manage postoperative pain, and they have high efficacy, a low risk for addiction and limited side effects. However, these anesthetics also have short half-lives, often necessitating continuous injection to obtain satisfactory pain relief. In the current work, we used a poly(lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA (PLGA-PEG-PLGA) temperature-sensitive gel to deliver a local anesthetic, ropivacaine hydrochloride (RP), to prolong its analgesic effect...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28244590/laser-thermal-ablation-for-mesiotemporal-epilepsy-analysis-of-ablation-volumes-and-trajectories
#16
Walter J Jermakowicz, Andres M Kanner, Samir Sur, Christina Bermudez, Pierre-Francois D'Haese, John Paul G Kolcun, Iahn Cajigas, Rui Li, Carlos Millan, Ramses Ribot, Enrique A Serrano, Naymee Velez, Merredith R Lowe, Gustavo J Rey, Jonathan R Jagid
OBJECTIVE: To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). METHODS: Clinical and radiographic data were reviewed from a prospectively maintained database of all patients undergoing LiTT for the treatment of mTLE at the University of Miami Hospital. Standard preoperative and postoperative evaluations, including contrast-enhanced magnetic resonance imaging (MRI) and neuropsychological testing, were performed in all patients...
February 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/28243337/changes-in-physicochemical-and-biological-properties-of-porcine-bone-derived-hydroxyapatite-induced-by-the-incorporation-of-fluoride
#17
Wei Qiao, Quan Liu, Zhipeng Li, Hanqing Zhang, Zhuofan Chen
As the main inorganic component of xenogenic bone graft material, bone-derived biological apatite (BAp) has been widely used in implant dentistry, oral and maxillofacial surgery and orthopedics. However, BAp produced via calcination of animal bones still suffers from some drawbacks, such as insufficient mechanical strength and inadequate degradation rate, which impede its application. Fluoride is known to play important roles in both physiological and pathological processes of human hard tissues for its double effects on bones and teeth...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28243141/bay11-7082-attenuates-neuropathic-pain-via-inhibition-of-nuclear-factor-kappa-b-and-nucleotide-binding-domain-like-receptor-protein-3-inflammasome-activation-in-dorsal-root-ganglions-in-a-rat-model-of-lumbar-disc-herniation
#18
Ailiang Zhang, Kun Wang, Lianghua Ding, Xinnan Bao, Xuan Wang, Xubin Qiu, Jinbo Liu
Lumbar disc herniation (LDH) is an important cause of radiculopathy, but the underlying mechanisms are incompletely understood. Many studies suggested that local inflammation, rather than mechanical compression, results in radiculopathy induced by LDH. On the molecular and cellular level, nuclear factor-kappa B (NF-κB) and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome have been implicated in the regulation of neuroinflammation formation and progression. In this study, the autologous nucleus pulposus (NP) was implanted in the left L5 dorsal root ganglion (DRG) to mimic LDH in rats...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28239778/-minimally-invasive-bypass-surgery-for-nasolacrimal-duct-obstruction-transcanalicular-laser-assisted-dacryocystorhinostomy
#19
K R Koch, C Cursiefen, L M Heindl
BACKGROUND: In recent years, the minimally invasive surgical procedure of transcanalicular laser-assisted dacryocystorhinostomy (TKL-DCR) has gained importance in the treatment of primary acquired nasolacrimal duct obstructions (PANDO). OBJECTIVES: Surgical indications, functional success rates, potential advantages, and complications of TKL-DCR are presented and compared with the standard procedures external (EXT-DCR) and endonasal DCR (EN-DCR). METHODS: The study comprises a PubMed literature review and our own clinical results...
February 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#20
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
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