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Thermal surgery

Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi
The present study aimed to evaluate whether the neoadjuvant chemoradiation response with concurrent thermal therapy for the treatment of rectal cancer can be predicted following the first thermic treatment. Eighty patients with primary rectal adenocarcinoma (≤12 cm from the anal verge) were included in this study. Fifty-four received surgery and pathological response was evaluated. Intensity-modulated radiotherapy was administered conventionally once daily 5 times/week. Neoadjuvant radiotherapy consisted of 50 Gy delivered to the planning target volume in 25 fractions...
July 2018: Oncology Letters
Chao Li, Wei Mao, Yun-Ke Huang, Zhi-Qi Zhao, Ning Lyu
Post-incision pain often occurs after surgery and is emergent to be treated in clinic. It hinders the rehabilitation of patients and easily leads to various types of postoperative complications. Acupuncture-combined anesthesia (ACA) is the combination of traditional acupuncture and modern anesthesia, which means acupuncture is applied at acupoints with general anesthesia. It was testified that ACA strengthened the analgesic effect and reduced the occurrence of postoperative pain, but its mechanism was not clear...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Mustafa Q Hameed, David Zurakowski, Mark R Proctor, Scellig S D Stone, Benjamin C Warf, Edward R Smith, Liliana C Goumnerova, Marek Swoboda, Tomer Anor, Joseph R Madsen
BACKGROUND: While a noninvasive flow determination would be desirable in the diagnosis of cerebrospinal fluid shunt malfunction, existing studies have not yet defined a role for thermal flow detection. OBJECTIVE: To evaluate a revised test protocol using a micropumper designed to transiently enhance flow during thermal testing to determine whether thermal detection of flow is associated with progression to shunt revision surgery. METHODS: Eighty-two unique tests were performed in 71 shunts...
June 16, 2018: Neurosurgery
Antonio Scarano, Felice Lorusso, Merla Arcangelo, Camillo D'Arcangelo, Renato Celletti, Pablo Santos de Oliveira
Purpose: Post-operative pain and swelling are frequently observed after sinus lift procedures. The aim of the present study was the clinical evaluation of swelling and pain of two different sinus flap lift techniques using a visual analogue scale (VAS), verbal rating scale (VRS), and infrared thermal imaging (i.e., thermography). Materials Methods : A randomized controlled trial was conducted with 15 patients (30 sinuses in total) randomly allocated into two groups. For the sinuses of Group I a trapezoidal flap was used, while for Group II a modified triangular flap without anterior release was utilized...
June 16, 2018: International Journal of Environmental Research and Public Health
Taraneh Moini Zanjani, Masoumeh Sabetkasaei, Behnaz Karimian, Farzaneh Labibi, Babak Farokhi, Nariman Mossafa
Background Evidence for a role of immune system in hyperalgesic pain states is increasing. Recent work in neuroimmunology suggests that the immune system does more than simply perform its well known functions of recognizing and removing invading pathogens and tumors. Interest in neuroinflammation and neuroimmune activation has grown rapidly in recent years with the recognition of the role of central nervous system inflammatiom and immune responses in the aetiology of pain states. Among various theories, the role of inflammatory responses of the injured nerve has recently received attention...
December 29, 2017: Scandinavian Journal of Pain
K K Frederiksen, P Kristensen, P H Honoré, G Gegelashvili, O J Bjerrum
Introduction An unmet medical need for more effective therapies of neuropathic pain exits. Here modulation of the glutaminergic system represents an unexplored possibility. Down-regulation ofglutamate transporters potentiates pain transmission by delaying the removal of glutamate from the synapse. In the spinal cord, glutamate transporter 1 (GLT-1) is responsible for more than 90% of the glutamate uptake. Ceftriaxone, a β-lactam, is believed to induce the expression of GLT-1 through the transcriptional factor (NF-ºB) pathway, which results in induced promoter activity and thereby increased synthesis of GLT-1 protein...
December 29, 2017: Scandinavian Journal of Pain
Kim Wildgaard, Thomas K Ringsted, Henrik Kehlet, Mads U Werner
Background/aims Quantitative sensory testing (QST) is a reference method in characterization of neuropathic pain components. Variability data on thermal thresholds have been presented for a number of diseases, but not for patients with persistent post-surgical pain. Thus, the objectives of the present study were to assess the day-to-day variation, but also topographic variability in thermal threshold assessments in post-thoracotomy pain syndrome (PTPS) patients. The variability in thermal thresholds between pre-specified sites, on the surgical and the non-surgical side were compared to each other and to the area of maximum pain...
December 29, 2017: Scandinavian Journal of Pain
Mads U Werner, Thomas K Ringsted, Henrik Kehlet, Kim Wildgaard
Background/aims Mirror-image sensory dysfunction (MISD) has been described in various medical conditions, but has not been systematically characterized following major surgery. Methods The presence of MISD was evaluated with standardized thermal and mechanical stimuli, in a group of preoperative patients scheduled for thoracotomy (n = 14) and in patients with post-thoracotomy pain syndrome (PTPS = 14). The primary outcome was areas with sensory dysfunction evaluated by dynamic sensory mapping with metal-rollers and a brush...
December 29, 2017: Scandinavian Journal of Pain
Yingcong Yang, Zhongyuan Xia, Qingtao Meng, Kang Liu, Yeda Xiao, Liwei Shi
This study was designed to examine the effect and mechanism of dexmedetomidine (Dex) on neuropathic pain (NP). The NP model was established by performing chronic sciatic nerve constriction injury (CCI). Seven days after CCI surgery, the rats were injected intraperitoneally with Dex, ZD7288 (an HCN channel inhibitor), and saline, respectively. The paw withdrawal threshold to mechanical stimulation and the thermal withdrawal latency tests were performed. After administration, the L4, L5 dorsal root ganglia (DRG) neurons of rats were isolated...
June 14, 2018: Neuroreport
A Jonsson, A-L Lind, M Hallberg, F Nyberg, T Gordh
Aims Neuropathic pain is a complex and painful condition, which is difficult to treat and causes a lot of suffering. The substance P (SP) system is well known to be involved in nociceptive signaling and it has previously been shown that the cerebrospinal fluid (CSF) level of SP is decreased in neuropathic pain. In this study we analyzed CSF from chronic neuropathic pain patients for the levels of SP1-7, an N-terminal fragment of SP with the ability to alleviate thermal as well as mechanical hypersensitivity in different animal models of chronic neuropathic pain, e...
December 29, 2017: Scandinavian Journal of Pain
Fernando da SilvaFiorin, Caroline Cunha do Espírito Santo, Adair Roberto Soares Santos, Michele Rechia Fighera, Luiz Fernando Freire Royes
BACKGROUND: This study demonstrated the effects of traumatic brain injury (TBI) and each step of the surgical procedure for a fluid percussion injury (FPI) model on periorbital allodynia. NEW METHOD: Adult male Wistar rats were divided in naive, incision, scraping, sham-TBI and TBI groups. Periorbital allodynia was evaluated using von Frey filaments, and heat hyperalgesia of the hindpaws was evaluated by a Plantar Test Apparatus. RESULTS: The statistical analyses revealed that the surgical procedure decreased von Frey filaments thresholds twenty-four hours after the surgery in all groups when compared to the naive group (p < 0...
June 13, 2018: Journal of Neuroscience Methods
Jacquelyn MacDonell, Niravkumar Patel, Gregory Fischer, E Clif Burdette, Jiang Qian, Vaibhav Chumbalkar, Goutam Ghoshal, Tamas Heffter, Emery Williams, Matthew Gounis, Robert King, Juliette Thibodeau, Gene Bogdanov, Olivia W Brooks, Erin Langan, Roy Hwang, Julie G Pilitsis
BACKGROUND: Ablative lesions are current treatments for epilepsy and brain tumors. Interstitial magnetic resonance (MR) guided focused ultrasound (iMRgFUS) may be an alternate ablation technique which limits thermal tissue charring as compared to laser therapy (LITT) and can produce larger ablation patterns nearer the surface than transcranial MR guided focused ultrasound (tcMRgFUS). OBJECTIVE: To describe our experience with interstitial focused ultrasound (iFUS) ablations in swine, using MR-guided robotically assisted (MRgRA) delivery...
June 14, 2018: Neurosurgery
Cristian Donos, Joshua Breier, Elliott Friedman, Patrick Rollo, Jessica Johnson, Lauren Moss, Stephen Thompson, Melissa Thomas, Omotola Hope, Jeremy Slater, Nitin Tandon
OBJECTIVES: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT is that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) epilepsy. To evaluate this, as well as to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and surgical or cognitive outcomes in 43 consecutive patients undergoing LITT for MTL epilepsy...
June 12, 2018: Epilepsia
Luca Viganò, Andrea Laurenzi, Luigi Solbiati, Fabio Procopio, Daniel Cherqui, Guido Torzilli
BACKGROUND: Patients with a single hepatocellular carcinoma (HCC) ≤3 cm and preserved liver function have the highest likelihood to be cured if treated. The most adequate treatment methods are yet a matter that is debated. METHODS: We reviewed the literature about open anatomic resection (AR), laparoscopic liver resection (LLR), and percutaneous thermal ablation (PTA). RESULTS: PTA is effective as resection for HCC < 2 cm, when they are neither subcapsular nor perivascular...
June 11, 2018: Digestive Surgery
Zhiyao Wang, Fan Liu, Min Wei, Yue Qiu, Chao Ma, Le Shen, Yuguang Huang
BACKGROUND: microRNA-146a-5p (miRNA-146a-5p) is a key molecule in the negative regulation pathway of TLRs and IL-1 receptor (TIR) signaling. Our recent study demonstrated that MyD88-dependent signaling pathway of TIR in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) plays a role in peripheral nerve injury-induced neuropathic pain. However, it was not clear whether and how miRNA-146a-5p regulates the TIR pathway of DRG and SDH in the development of neuropathic pain. METHODS: The sciatic nerve chronic constriction injury (CCI) model of rat was used to induce chronic neuropathic pain...
June 9, 2018: Journal of Neuroinflammation
Amjad Belramman, Roshan Bootun, Tristan R A Lane, Alun H Davies
Varicose veins are a very common condition and have been the subject of a recent proliferation of treatment modalities. The advent of the endovenous treatment era has led to a confusing array of different techniques that can be daunting when making the transition from traditional surgery. All modalities offer excellent results in the right situation, and each has its own treatment profile. Thermal ablation techniques have matured and have a reassuring and reliable outcome, but the arrival of nonthermal techniques has delivered further options for both patient and surgeon...
January 1, 2018: Angiology
Edwin A Takahashi, Kristin A Kinsman, Grant D Schmit, Thomas D Atwell, John J Schmitz, Brian T Welch, Matthew R Callstrom, Jennifer R Geske, A Nicholas Kurup
PURPOSE: To evaluate the safety and oncologic efficacy of percutaneous thermal ablation of intrahepatic cholangiocarcinoma (ICC) and identify risk factors for local tumor progression (LTP). MATERIALS AND METHODS: Retrospective review of an institutional tumor ablation registry demonstrated that 20 patients (9 males, 11 females; mean age 62.5 ± 15.8 years) with 50 ICCs (mean size 1.8 ± 1.3 cm) were treated with percutaneous radiofrequency ablation (RFA) or microwave ablation (MWA) between 2006 and 2015...
June 4, 2018: Abdominal Radiology
John C Bischof, Kenneth R Diller
This review explores bioheat transfer applications at multiple scales from nanoparticle (NP) heating to whole-body thermoregulation. For instance, iron oxide nanoparticles are being used for nanowarming, which uniformly and quickly rewarms 50-80-mL (≤5-cm-diameter) vitrified systems by coupling with radio-frequency (RF) fields where standard convective warming fails. A modification of this approach can also be used to successfully rewarm cryopreserved fish embryos (∼0.8 mm diameter) by heating previously injected gold nanoparticles with millisecond pulsed laser irradiation where standard convective warming fails...
June 4, 2018: Annual Review of Biomedical Engineering
Sheng-Min Huang, Hao-Li Liu, Dai-Wei Li, Meng-Lin Li
High-intensity focused ultrasound (HIFU) has demonstrated the capacity to be used for local thermal ablation in clinical surgery; however, relying solely on conventional ultrasound B-mode imaging to monitor HIFU thermal ablation and determine ablation levels remains a challenge. Here, we experimentally demonstrate the ability to use Nakagami imaging to monitor HIFU-induced thermal lesions in porcine livers ex vivo. Ultrasonic Nakagami imaging has been proven to be able to characterize tissues with different scatterer concentrations and distributions...
June 1, 2018: Ultrasonic Imaging
Sang Hwan Lee, Seung Hyun Sim, Sae Hwi Ki
BACKGROUND: Patients who have undergone microsurgery for reconstruction with a free flap or finger replantation are vulnerable to heat injury. Moreover, some of these injuries can occur at low temperatures. Although the temperature does not reach the threshold to cause burns in the adjacent normal tissues, burns can occur in the areas that underwent microsurgery. On the other hand, this type of burn is not completely understood and there are few reports of the clinical prognosis. METHODS: The medical records of patients who received warm therapy using an infrared heat lamp with the appropriate temperature after hand surgery from January 2009 to December 2016 were reviewed...
May 30, 2018: Annals of Plastic Surgery
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