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https://www.readbyqxmd.com/read/28329141/frequent-spread-of-plasmodium-vivax-malaria-maintains-high-genetic-diversity-at-the-myanmar-china-border-without-distance-and-landscape-barriers
#1
Eugenia Lo, Nancy Lam, Elizabeth Hemming-Schroeder, Jennifer Nguyen, Guofa Zhou, Ming-Chieh Lee, Zhaoqing Yang, Liwang Cui, Guiyun Yan
Background.: In Myanmar, civil unrest and the establishment of internally displaced persons (IDP) settlements along the Myanmar-China border have impacted malaria transmission. Methods.: Microsatellite markers were used to examine source-sink dynamics for Plasmodium vivax between IDP and surrounding villages in the border region. Genotypic structure and diversity were compared across the three years following the establishment of IDP in order to infer demographic history...
March 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28322694/plasmodium-malariae-prevalence-and-csp-gene-diversity-kenya-2014-and-2015
#2
Eugenia Lo, Kristie Nguyen, Jennifer Nguyen, Elizabeth Hemming-Schroeder, Jiaobao Xu, Harrisone Etemesi, Andrew Githeko, Guiyun Yan
In Africa, control programs that target primarily Plasmodium falciparum are inadequate for eliminating malaria. To learn more about prevalence and genetic variability of P. malariae in Africa, we examined blood samples from 663 asymptomatic and 245 symptomatic persons from western Kenya during June-August of 2014 and 2015. P. malariae accounted for 5.3% (35/663) of asymptomatic infections and 3.3% (8/245) of clinical cases. Among asymptomatic persons, 71% (32/45) of P. malariae infections detected by PCR were undetected by microscopy...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322418/associations-of-sodium-potassium-and-protein-intake-with-blood-pressure-and-hypertension-in-switzerland
#3
Nicolas Glatz, Aline Chappuis, David Conen, Paul Erne, Antoinette Péchère-Bertschi, Idris Guessous, Valentina Forni, Luca Gabutti, Franco Muggli, Augusto Gallino, Daniel Hayoz, Isabelle Binet, Paolo Suter, Fred Paccaud, Murielle Bochud, Michel Burnier
BACKGROUND: Nutritional factors play an important role in the regulation of blood pressure and in the development of hypertension. In this analysis, we explored the associations of 24-hour urinary Na+, K+ and urea excretion with blood pressure levels and the risk of hypertension in the Swiss population, taking regional linguistic differences into account. METHODS: The Swiss Survey on Salt is a population based cross-sectional study that included 1336 subjects from the three main linguistic regions (French, German and Italian) of Switzerland...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28322231/alix-is-required-during-development-for-normal-growth-of-the-mouse-brain
#4
Marine H Laporte, Christine Chatellard, Victoria Vauchez, Fiona J Hemming, Jean-Christophe Deloulme, Frédérique Vossier, Béatrice Blot, Sandrine Fraboulet, Rémy Sadoul
Alix (ALG-2 interacting protein X) drives deformation and fission of endosomal and cell surface membranes and thereby intervenes in diverse biological processes including cell proliferation and apoptosis. Using embryonic fibroblasts of Alix knock-out mice, we recently demonstrated that Alix is required for clathrin-independent endocytosis. Here we show that mice lacking Alix suffer from severe reduction in the volume of the brain which affects equally all regions examined. The cerebral cortex of adult animals shows normal layering but is reduced in both medio-lateral length and thickness...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321633/dietary-intake-of-minerals-vitamins-and-trace-elements-among-geriatric-population-in-india
#5
Aakriti Gupta, Preetika Khenduja, Ravindra Mohan Pandey, Hem Chandra Sati, Nighat Yaseen Sofi, Umesh Kapil
The geriatric population is at a high risk of developing deficiencies of essential micronutrients such as minerals, vitamins, and trace elements and their related deficiency signs and symptoms. Scarce data is available on the dietary intake of essential micronutrients among geriatric subjects in India. Hence, to fill the gap in the existing knowledge, a community-based cross-sectional study was conducted during 2015-2016 in District Nainital, Uttarakhand State, India. A total of 255 geriatric subjects were enrolled from 30 clusters (villages) identified by using population proportionate to size sampling methodology...
March 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28317095/evaluating-helicopter-emergency-medical-missions-a-reliability-study-of-the-hems-benefit-and-naca-scores
#6
L Raatiniemi, J Liisanantti, M Tommila, S Moilanen, P Ohtonen, M Martikainen, V Voipio, J Reitala, T Iirola
BACKGROUND: The benefits of the Helicopter Emergency Medical Service (HEMS) and dispatch accuracy are continuously debated, and a widely accepted score to measure the benefits of the mission is lacking. The HEMS Benefit Score (HBS) has been used in Finnish helicopter emergency medical services, but studies are lacking. The National Advisory Committee for Aeronautics (NACA) score is widely used to measure the severity of illness or injury in the pre-hospital setting, but it has many critics due to its subjectivity...
March 19, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28295573/therapeutic-plasma-exchange-for-perioperative-management-of-patients-with-congenital-factor-xi-deficiency
#7
Mohamed S Alsammak, Aneel A Ashrani, Jeffrey L Winters, Rajiv K Pruthi
BACKGROUND: Factor XI (FXI) deficiency (hemophilia C [HEM-C]) is a bleeding disorder with unpredictable severity that correlates poorly with FXI coagulation activity (FXI:C). It poses a perioperative hemostatic management challenge. For US patients with severe disease, fresh frozen plasma (FFP) or, in current use, thawed plasma is the most readily available option but comes with risk of volume overload. We report our experience of using therapeutic plasma exchange (TPE) as an alternative perioperative management strategy...
March 15, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28289002/unusual-cause-of-renal-stone-following-robotic-pyeloplasty
#8
Siddharth Yadav, Prabhjot Singh, Brusabhanu Nayak, Prem Nath Dogra
Non-absorbable Hem-o-Lok clips are commonly used for vascular pedicle control or suture stabilisation during laparoscopic or robotic reconstructive procedures. As they are placed close to suture line and with tension, these clips have a propensity to migrate. We report a case of a 22-year-old man with history of bilateral robotic pyeloplasty presenting with left inferior calyceal stone. He underwent left mini percutaneous nephrolithotomy which revealed an encrusted migrated Hem-o-Lok clip that was used to close the mesenteric window formed during transmesocolic pyeloplasty...
March 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28283949/impact-of-chemical-organic-and-bio-fertilizers-application-on-bell-pepper-capsicum-annuum-l-and-biological-parameters-of-myzus-persicae-sulzer-hem-aphididae
#9
M Mardani-Talaee, J Razmjou, G Nouri-Ganbalani, M Hassanpour, B Naseri
Myzus persicae (Sulzer) is a polyphagous aphid that causes chlorosis, necrosis, stunting, and reduce growth rate of the host plants. In this research, the effects of Zinc sulfate and vermicompost (30%), Bacillus subtilis, Pseudomonas fluorescens, Glomus intraradices, G. intraradices × B. subtilis, and G. intraradices × P. fluorescens compared to control was investigated on the growth characters of Capsicum annuum L. and biological parameters of M. persicae. Different fertilizers caused a significant effect on growth characters of C...
March 11, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28282604/the-fecal-occult-blood-test-as-a-tool-for-improved-outpatient-qualification-for-colonoscopy-a-single-center-experience-and-10-year-follow-up-survey
#10
Zbigniew Banaszkiewicz, Jacek Budzyński, Krzysztof Tojek, Paweł Jarmocik, Jacek Frasz, Marcin Mrozowski, Maciej Świtoński, Arkadiusz Jawień
PURPOSE: Colonoscopy is not widely and easily available in all countries, even for symptomatic patients. This is one of the causes of tumors not being diagnosed until an advanced stage. The aim of this study was to estimate the efficacy of the fecal occult blood test (FOBT) in the diagnostic work-up of outpatients referred to a colorectal unit due to indistinct abdominal symptoms. PATIENTS/METHODS: Among 10418 consecutive symptomatic individuals referred to the outpatient clinic, an immunochemical FOBT (Hem-Check 1(®)) was recommended for 9432 patients with indistinct symptoms as a tool for qualifying them for colonoscopy...
March 7, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28281910/orthodontic-cost-awareness-amongst-orthodontic-trainees-in-a-university-teaching-hospital
#11
Nicholas Hemmings, Jamie Gwilliam, Gurprit K Bhamrah
INTRODUCTION: After successful completion of orthodontic membership examinations, post-graduate specialty trainees are deemed proficient to work independently in primary care, where some understanding of the costs of providing treatment may be required. Financial management forms part of Module 33 of the Specialty Advisory Committee (SAC) curriculum for orthodontic training. OBJECTIVES: Establish knowledge levels of the cost of orthodontic items by King's College Hospital (KCH) Orthodontic trainees...
March 10, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28272573/erlend-hem-svarer
#12
Erlend Hem
No abstract text is available yet for this article.
March 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28265069/clinical-concentrations-of-chemically-diverse-general-anesthetics-minimally-affect-lipid-bilayer-properties
#13
Karl F Herold, R Lea Sanford, William Lee, Olaf S Andersen, Hugh C Hemmings
General anesthetics have revolutionized medicine by facilitating invasive procedures, and have thus become essential drugs. However, detailed understanding of their molecular mechanisms remains elusive. A mechanism proposed over a century ago involving unspecified interactions with the lipid bilayer known as the unitary lipid-based hypothesis of anesthetic action, has been challenged by evidence for direct anesthetic interactions with a range of proteins, including transmembrane ion channels. Anesthetic concentrations in the membrane are high (10-100 mM), however, and there is no experimental evidence ruling out a role for the lipid bilayer in their ion channel effects...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28259174/analysis-of-cluster-randomised-stepped-wedge-trials-with-repeated-cross-sectional-samples
#14
Karla Hemming, Monica Taljaard, Andrew Forbes
BACKGROUND: The stepped wedge cluster randomised trial (SW-CRT) is increasingly being used to evaluate policy or service delivery interventions. However, there is a dearth of trials literature addressing analytical approaches to the SW-CRT. Perhaps as a result, a significant number of published trials have major methodological shortcomings, including failure to adjust for secular trends at the analysis stage. Furthermore, the commonly used analytical framework proposed by Hussey and Hughes makes several assumptions...
March 4, 2017: Trials
https://www.readbyqxmd.com/read/28255310/binding-mode-of-triazole-derivatives-as-aromatase-inhibitors-based-on-docking-protein-ligand-interaction-fingerprinting-and-molecular-dynamics-simulation-studies
#15
Ayyub Mojaddami, Amirhossein Sakhteman, Masood Fereidoonnezhad, Zeinab Faghih, Atena Najdian, Soghra Khabnadideh, Hossein Sadeghpour, Zahra Rezaei
Aromatase inhibitors (AIs) as effective candidates have been used in the treatment of hormone-dependent breast cancer. In this study, we have proposed 300 structures as potential AIs and filtered them by Lipinski's rule of five using DrugLito software. Subsequently, they were subjected to docking simulation studies to select the top 20 compounds based on their Gibbs free energy changes and also to perform more studies on the protein-ligand interaction fingerprint by AuposSOM software. In this stage, anastrozole and letrozole were used as positive control to compare their interaction fingerprint patterns with our proposed structures...
February 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28253401/netrin-4-mediates-corneal-hemangiogenesis-but-not-lymphangiogenesis-in-the-mouse-model-of-suture-induced-neovascularization
#16
Anna-Karina B Maier, Sabrina Klein, Norbert Kociok, Aline I Riechardt, Enken Gundlach, Nadine Reichhart, Olaf Strauß, Antonia M Joussen
Purpose: Netrin-4, a secreted protein, is found in the basement membrane of blood vessels and acts as a key regulator of angiogenesis. Here we investigated the role of Netrin-4 in the mouse-model of suture-induced corneal hem- and lymphangiogenesis. Methods: Corneal hem- and lymphangiogenesis were induced in Netrin-4-deficient (Ntn4-/-) and wild-type (WT) mice by placing three 11-0 nylon sutures intrastromally. Fourteen days after suturing, the vascularized area was analyzed via corneal flat mount immunohistochemistry...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28252519/validation-of-the-omron-hem-9210t-by-the-ansi-aami-iso-81060-2-2013-with-two-novel-cuffs-wide-range-and-extra-large
#17
Bruce S Alpert
OBJECTIVE: The aims of this ANSI/AAMI/ISO validation study were to assess the accuracy of the Omron HEM-9210T, developed to utilize a small cuff, a wide-range cuff, and an extra-large cuff in the adult population. If accurate, the wide-range and extra-large cuffs will be of clinical significance in both medical and self-measurement environments. METHODS: Individuals were recruited at an independent clinical research center. Eighty-five patients comprised the final analyses...
March 1, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28247485/is-the-first-urinary-albumin-creatinine-ratio-acr-in-women-with-suspected-pre-eclampsia-a-prognostic-factor-for-maternal-and-neonatal-adverse-outcome-a-retrospective-cohort-study
#18
Eleni G Elia, Amy O Robb, Karla Hemming, Malcolm J Price, Richard D Riley, Anna French-Constant, Fiona C Denison, Mark D Kilby, Rachel K Morris, Sarah J Stock
INTRODUCTION: The aim of this study was to determine the prognostic value of the first urinary albumin/creatinine ratio (ACR) for adverse maternal and neonatal outcomes and how it relates to other prognostic factors. MATERIAL AND METHODS: We performed a retrospective cohort study from December 2009 to February 2012 with analysis of demographic, clinical and biochemical data from two obstetric day assessment units in hospitals in Southeast Scotland. We included 717 pregnant women, with singleton pregnancies after 20 weeks gestation, referred for evaluation of suspected pre-eclampsia and having their first ACR performed...
March 1, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28217519/prevalence-of-vitamin-d-deficiency-and-associated-risk-factors-among-children-residing-at-high-altitude-in-shimla-district-himachal-pradesh-india
#19
Umesh Kapil, Ravindra Mohan Pandey, Ravinder Goswami, Brij Sharma, Neetu Sharma, Lakshmy Ramakrishnan, Gajendra Singh, Neha Sareen, Hem Chandra Sati, Aakriti Gupta, Nighat Yaseen Sofi
INTRODUCTION: Vitamin D is important for bone development in children. A high prevalence of Vitamin D deficiency (VDD) has been documented from different parts of India. However, limited data are available on VDD among children residing at high altitude region of country. OBJECTIVES: To assess the prevalence of VDD and associated risk factors among children in the age group of 6-18 years in Shimla, Himachal Pradesh. METHODS: A community-based cross-sectional study was conducted in the year 2014-2015...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28210554/preoperative-psychosocial-characteristics-may-predict-body-image-and-sexuality-two-years-after-risk-reducing-mastectomy-a-prospective-study
#20
Dmytro Unukovych, Hemming Johansson, Yvonne Brandberg
BACKGROUND: Risk-reducing mastectomy (RRM) in patients at high risk has become more available and the rates of both bilateral (BRRM) and contralateral (CRRM) procedures are increasing. For women opting for RRM, psychosocial well-being, body image and sexuality are known to be important patient-reported outcomes. The aim of the present study was to investigate baseline health-related quality of life (HRQoL) and emotional distress (anxiety and depression) as predictors of body image and sexuality two years after RRM in women undergoing CRRM and BRRM...
February 2017: Gland Surgery
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