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https://www.readbyqxmd.com/read/29045971/-technical-improvement-in-retroperitoneal-laparoscopic-living-donor-nephrectomy-report-of-193-cases
#1
L Zhao, L L Ma, H X Zhang, X F Hou, L Liu, Y Fu, Y G Kou, Y M Song
OBJECTIVE: To summarize our experience of retroperitoneal laparoscopic living donor nephrectomy, our continuous technical improvements and refinement of this skill and standardization of each procedure of this operation. METHODS: Having approved by hospital ethical committee and local government administration, a total of 193 living donors underwent retroperitoneal laparoscopic living donor nephrectomy from Dec.2003 to Feb. 2016 in our department. Under general anaesthesia, the operation was performed through 3 lumbar ports...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29043730/ikke-sham-p%C3%A3-norsk
#2
Erlend Hem
No abstract text is available yet for this article.
October 16, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29043720/e-hem-svarer
#3
Erlend Hem
No abstract text is available yet for this article.
October 16, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29037168/locating-helicopter-emergency-medical-service-bases-to-optimise-population-coverage-versus-average-response-time
#4
Alan A Garner, Pieter L van den Berg
BACKGROUND: New South Wales (NSW), Australia has a network of multirole retrieval physician staffed helicopter emergency medical services (HEMS) with seven bases servicing a jurisdiction with population concentrated along the eastern seaboard. The aim of this study was to estimate optimal HEMS base locations within NSW using advanced mathematical modelling techniques. METHODS: We used high resolution census population data for NSW from 2011 which divides the state into areas containing 200-800 people...
October 16, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/29035285/dermoscopy-and-patch-testing-in-patients-with-lichen-planus-pigmentosus-on-face-a-cross-sectional-observational-study-in-fifty-indian-patients
#5
Vinod Kumar Sharma, Vishal Gupta, Piyush Pahadiya, Kamal Kumar Vedi, Sudheer Arava, M Ramam
BACKGROUND: Lichen planus pigmentosus (LPP) is a common cause of facial melanosis in the dark-skinned population. At present, information on dermoscopy and patch testing in LPP is limited. OBJECTIVES: To describe dermoscopic findings and study the role of patch testing in patients with LPP on the face. METHODS: Facial lesions of 50 patients with LPP were studied dermoscopically, followed by histological evaluation. Patch and photopatch tests with the Indian Standard Series and Scandinavian series, respectively, and patient's own cosmetics were performed on all patients...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29029326/letter-electric-beats-open-new-frontiers-for-deep-brain-stimulation
#6
Casey H Halpern, Kai J Miller, Hemmings Wu, Peter A Tass
No abstract text is available yet for this article.
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29027505/impact-of-non-uniform-correlation-structure-on-sample-size-and-power-in-multiple-period-cluster-randomised-trials
#7
J Kasza, K Hemming, R Hooper, Jns Matthews, A B Forbes
Stepped wedge and cluster randomised crossover trials are examples of cluster randomised designs conducted over multiple time periods that are being used with increasing frequency in health research. Recent systematic reviews of both of these designs indicate that the within-cluster correlation is typically taken account of in the analysis of data using a random intercept mixed model, implying a constant correlation between any two individuals in the same cluster no matter how far apart in time they are measured: within-period and between-period intra-cluster correlations are assumed to be identical...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29023578/factors-related-to-environmental-barriers-experienced-by-persons-with-and-without-disabilities-in-diverse-african-settings
#8
Surona Visagie, Arne H Eide, Karin Dyrstad, Hasheem Mannan, Leslie Swartz, Marguerite Schneider, Gubela Mji, Alister Munthali, Mustafa Khogali, Gert van Rooy, Karl-Gerhard Hem, Malcolm MacLachlan
This paper explores differences in experienced environmental barriers between individuals with and without disabilities and the impact of additional factors on experienced environmental barriers. Data was collected in 2011-2012 by means of a two-stage cluster sampling and comprised 400-500 households in different sites in South Africa, Sudan Malawi and Namibia. Data were collected through self-report survey questionnaires. In addition to descriptive statistics and simple statistical tests a structural equation model was developed and tested...
2017: PloS One
https://www.readbyqxmd.com/read/29022633/in-site-encapsulating-gold-nanowires-into-hemin-coupled-protein-scaffolds-through-biomimetic-assembly-towards-the-nanocomposites-with-strong-catalysis-electrocatalysis-and-fluorescence-properties
#9
Shuai Li, Liyan Zhang, Yao Jiang, Shuyun Zhu, Xiaoxia Lv, Zhiqiang Duan, Hua Wang
An efficient and green biomimetic assembly protocol was developed for the fabrication of multifunctional nanocomposites by mimicking the configuration of natural protein enzymes. Bovine serum albumin (BSA) as the protein model was first split to produce the disassembled BSA (dBSA) of linear polymer and then coupled with catalytic Hemin (Hem). The yielded dBSA-Hem scaffolds were utilized to in-site encapsulate gold nanoclusters (AuNCs) through biominerization, yielding the dBSA-Hem-AuNCs. It was discovered that the nanocomposites could display the well-defined composition and spheric morphology...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28990276/exome-sequencing-reveals-naa15-and-puf60-as-candidate-genes-associated-with-intellectual-disability
#10
Jin J Zhao, Jonatan Halvardson, Cecilia S Zander, Ammar Zaghlool, Patrik Georgii-Hemming, Else Månsson, Göran Brandberg, Helena E Sävmarker, Carina Frykholm, Ekaterina Kuchinskaya, Ann-Charlotte Thuresson, Lars Feuk
Intellectual Disability (ID) is a clinically heterogeneous condition that affects 2-3% of population worldwide. In recent years, exome sequencing has been a successful strategy for studies of genetic causes of ID, providing a growing list of both candidate and validated ID genes. In this study, exome sequencing was performed on 28 ID patients in 27 patient-parent trios with the aim to identify de novo variants (DNVs) in known and novel ID associated genes. We report the identification of 25 DNVs out of which five were classified as pathogenic or likely pathogenic...
October 9, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28982851/modulation-of-pi3k-pten-pathway-does-not-affect-catalytic-activity-of-pdk1-in-jurkat-cells
#11
Keum-Jin Yang, Longzhen Piao, Sanghee Shin, So-Yeon Shin, Yuwen Li, Hyunji Lee, Quangdon Tran, Jisoo Park, Suntaek Hong, Derek P Brazil, Brian A Hemmings, Seon-Hwan Kim, Jongsun Park
Unopposed phosphoinositide 3-kinase (PI3K) activity and 3-phosphoinositide production in Jurkat cells, due to a mutation in the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor-suppressor protein, results in deregulation of PH domain-containing proteins including the serine/threonine kinase PKB. In Jurkat cells, PKB is constitutively active and phosphorylated at the activation-loop residue (Thr308). 3-Phosphoinositide-dependent protein kinase-1 (PDK1), an enzyme that also contains a PH domain, catalyses Thr308 phosphorylation of PKB in addition to other kinase families such as PKC isoforms...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982624/robotic-retrocaval-metastasectomy-after-an-ipsilateral-radical-nephrectomy
#12
Ryan J Nelson, Jeremy H Reese, Paurush Babbar, Jihad H Kaouk
OBJECTIVE: Robotic management of a retrocaval metastasis can be challenging because of prior surgery leading to scarring and obscure surgical planes around vital structures. We present our robotic approach and technique to manage a large retrocaval, biopsy-proven, metastatic mass after previous laparoscopic right radical nephrectomy with concomitant adrenalectomy 10 years ago. METHODS: We present a 62-year-old man who previously underwent a laparoscopic right radical nephrectomy for pT1bNxMx chromophobe renal cell carcinoma (RCC) in 2007...
September 2017: Urology
https://www.readbyqxmd.com/read/28975883/prehospital-interventions-before-and-after-implementation-of-a-physician-staffed-helicopter
#13
Asger Sonne, Sandra Wulffeld, Jacob Steinmetz, Lars S Rasmussen, Rasmus Hesselfeldt
INTRODUCTION: Implementation of a physician-staffed helicopter emergency medical service (HEMS) in eastern Denmark was associated with increased survival for severely injured patients. This study aimed to assess the potential impact of advanced prehospital interventions by comparing the proportion of patients who received those interventions before and after the HEMS implementation. METHODS: A post-hoc analysis of a prospective before-after study. We included trauma patients with Injury Severity Scores above three who had been admitted to seven emergency departments or one level 1 trauma centre in the course of a five-month period before and a 12-month period after the HEMS implementation...
October 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28972337/e-hem-svarer
#14
Erlend Hem
No abstract text is available yet for this article.
September 18, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28969326/thinking-fast-and-slow-highlights-from-the-2016-bja-seminar-on-anaesthetic-neurotoxicity-and-neuroplasticity
#15
S G Soriano, L Vutskits, V Jevtovic-Todorovic, H C Hemmings
No abstract text is available yet for this article.
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28966818/intraoperative-monitoring-for-spinal-radiculomedullary-artery-aneurysm-occlusion-treatment-what-when-and-how-long
#16
Federico Landriel, Matteo Baccanelli, Santiago Hem, Eduardo Vecchi, Mariana Bendersky, Claudio Yampolsky
BACKGROUND: Spinal radiculomedullary artery aneurysms are extremely rare. Treatment should be tailored to clinical presentation, distal aneurysm flow, and lesion anatomical features. When a surgical occlusion is planned, it is necessary to evaluate whether intraoperative monitoring (IOM) should be considered as an indispensable tool to prevent potential spinal cord ischemia. METHODS: We present a patient with symptoms and signs of spinal subarachnoid hemorrhage resulting from the rupture of a T4 anterior radiculomedullary aneurysm who underwent open surgical treatment under motor evoked potential (MEP) monitoring...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28966114/aortic-cannulation-in-debakey-type-i-aortic-dissection-facilitates-subsequent-deployment-of-a-frozen-elephant-trunk
#17
Jonathan M Hemli, Allan Mattia, Eden Payabyab, Yuriy Dudiy, S Jacob Scheinerman, Derek R Brinster
Arterial cannulation in acute DeBakey type I dissection can be difficult. Moreover, the residual dissected aorta is susceptible to further adverse events in the future. Implanting a stent-graft into the descending aorta during the initial dissection repair ('frozen elephant trunk') has been demonstrated to promote favourable aortic remodelling, mitigating some of these longer-term complications. We describe a technique for cannulation of the ascending aorta in acute dissection that facilitates expeditious antegrade deployment of a frozen elephant trunk...
September 15, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28956068/amyloid-precursor-protein-products-concentrate-in-a-subset-of-exosomes-specifically-endocytosed-by-neurons
#18
Karine Laulagnier, Charlotte Javalet, Fiona J Hemming, Mathilde Chivet, Gaëlle Lachenal, Béatrice Blot, Christine Chatellard, Rémy Sadoul
Amyloid beta peptide (Aβ), the main component of senile plaques of Alzheimer's disease brains, is produced by sequential cleavage of amyloid precursor protein (APP) and of its C-terminal fragments (CTFs). An unanswered question is how amyloidogenic peptides spread throughout the brain during the course of the disease. Here, we show that small lipid vesicles called exosomes, secreted in the extracellular milieu by cortical neurons, carry endogenous APP and are strikingly enriched in CTF-α and the newly characterized CTF-η...
September 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28945665/validation-of-the-omron-hem-7320-la-upper-arm-blood-pressure-monitor-with-intelli-wrap-technology-cuff-hem-fl1-for-self-measurement-and-clinic-use-according-to-the-european-society-of-hypertension-international-protocol-revision-2010-in-the-mexican-population
#19
Fernando Grover-Páez, Ernesto G Cardona-Muñoz, David Cardona-Müller, Víctor H Guzmán-Saldívar, Mariana Rodríguez-De la Cerda, Mayra B Jiménez-Cázarez, Sylvia E Totsuka-Sutto, Guillermo A Alanis-Sánchez, Carlos G Ramos-Becerra
The aim of this study was to determine the accuracy of the Omron HEM-7320-LA with Intelli Wrap technology cuff HEM-FL1 for self-measurement and clinic blood pressure (BP) measurement according to the European Society of Hypertension International Protocol revision 2010. The evaluation was performed in 39 individuals. The mean age of the participants was 47.9±14 years; systolic BP was 145.2±24.3 mmHg (range: 97-190), diastolic BP was 90.9±12.9 mmHg (range: 68-120), and arm circumference was 30.8±4 cm (range: 25-38...
September 22, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28943478/sexual-dimorphism-of-metabolic-and-vascular-dysfunction-in-aged-mice-and-those-lacking-the-sphingosine-1-phosphate-receptor-3
#20
Amanda T Cao, Martina Mackova, Daniel Kerage, David N Brindley, Denise G Hemmings
Elderly people often suffer adverse health because of inflammation associated with poor metabolism and cardiovascular dysfunction, but these conditions present differently in men and women. We performed experiments in aged male and female mice to understand this sexual dimorphism. We focused on sphingosine 1-phosphate (S1P) signaling, which has both protective and detrimental effects on vascular and metabolic function. We examined vascular function of mesenteric (resistance) arteries from aged male and female wild-type (WT) mice compared to littermate S1P receptor 3 (S1PR3) knockouts (KO)...
September 22, 2017: Experimental Gerontology
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