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https://www.readbyqxmd.com/read/28717994/modeling-and-investigation-of-new-explosive-materials-based-on-n-3-5-dimethyl-2-4-6-trinitrophenyl-1h-1-2-4-triazol-3-amine
#1
Jelena Tamuliene, Jonas Sarlauskas, Svajone Bekesiene
This study presents an investigation of the effects of adding extra nitro group substituents to N-(3,5-dimethyl-2,4,6-trinitrophenyl)-1H-1,2,4-triazol-3-amine (HEM-II) on its thermal and chemical stability as well as its explosive performance. An analysis of the thermal stabilities of HEM-II and HEM-II-based molecules based on an investigation of the binding energy per atom for each molecule was performed. The values of the gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) as well as those of the chemical hardness and softness for HEM-II and the HEM-II-based molecules were studied to determine the chemical stabilities of these molecules...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28717647/intracranial-hematoma-detection-by-near-infrared-spectroscopy-in-a-helicopter-emergency-medical-service-practical-experience
#2
Patrick Schober, Sebastiaan M Bossers, Lothar A Schwarte
In (helicopter) emergency medical services, (H)EMS, the prehospital detection of intracranial hematomas should improve patient care and the triage to specialized neurosurgical hospitals. Recently, noninvasive detection of intracranial hematomas became possible by applying transcranial near infrared spectroscopy (NIRS). Herein, second-generation devices are currently available, for example, the Infrascanner 2000 (Infrascan), that appear suited also for prehospital (H)EMS applications. Since (H)EMS operations are time-critical, we studied the Infrascanner 2000 as a "first-time-right" monitor in healthy volunteers (n = 17, hospital employees, no neurologic history)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28711949/pediatric-out-of-hospital-cardiopulmonary-resuscitation-by-helicopter-emergency-medical-service-does-it-has-added-value-compared-to-regular-emergency-medical-service
#3
X R J Moors, K Rijs, D Den Hartog, R J Stolker
PURPOSE: To determine the outcome of out-of-hospital (OOH) cardiopulmonary resuscitation (CPR) and the advanced life support (ALS) procedures provided in pediatrics by the Rotterdam Helicopter Emergency Medical Service (HEMS) METHODS: Retrospective evaluation of all pediatric (0-17 years) OOH cardiopulmonary arrests within a 6-year period and attended by the Rotterdam HEMS team. RESULTS: There were 201 OOH CPRs from October 2008 until October 2014. Endotracheal intubation was performed in 164 cases and done by HEMS in 104 patients (63%), intraosseous/intravenous cannulation 43/27 times, and additional medication given by HEMS in 70 patients (35%)...
July 15, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28711022/pre-clinical-efficacy-assessment-of-malva-sylvestris-on-chronic-skin-inflammation
#4
Arthur S Prudente, Graziela Sponchiado, Daniel A G B Mendes, Bruna S Soley, Daniela A Cabrini, Michel F Otuki
In the search for improved quality of life, the treatment of skin diseases like psoriasis (hyperproliferative disease) is valid, since it causes huge social discomfort to the patient. In this context, earlier studies showed that Malva sylvestris L. has anti-inflammatory activity demonstrated by acute animal models of skin inflammation, becoming a promising target for further studies. The present investigation aimed to verify the effect of hydroalcoholic extract of M. sylvestris (HEMS) on the chronic inflammatory and hyperproliferative response caused by multiple applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on mouse ears...
July 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28710062/how-to-design-efficient-cluster-randomised-trials
#5
K Hemming, S Eldridge, G Forbes, C Weijer, M Taljaard
No abstract text is available yet for this article.
July 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28708860/charged-amino-acid-variability-related-to-n-glyco-sylation-and-epitopes-in-a-h3n2-influenza-hem-agglutinin-and-neuraminidase
#6
Zhong-Zhou Huang, Liang Yu, Ping Huang, Li-Jun Liang, Qing Guo
BACKGROUND: The A/H3N2 influenza viruses circulated in humans have been shown to undergo antigenic drift, a process in which amino acid mutations result from nucleotide substitutions. There are few reports regarding the charged amino acid mutations. The purpose of this paper is to explore the relations between charged amino acids, N-glycosylation and epitopes in hemagglutinin (HA) and neuraminidase (NA). METHODS: A total of 700 HA genes (691 NA genes) of A/H3N2 viruses were chronologically analyzed for the mutational variants in amino acid features, N-glycosylation sites and epitopes since its emergence in 1968...
2017: PloS One
https://www.readbyqxmd.com/read/28705902/long-term-risk-of-cancer-development-in-adult-patients-with-idiopathic-aplastic-anemia-after-treatment-with-anti-thymocyte-globulin
#7
Joost Gk van der Hem, Liesbeth C de Wreede, Anneke Brand, Hendrik Veelken, Jh Frederik Falkenburg, Constantijn Jm Halkes
No abstract text is available yet for this article.
July 13, 2017: Haematologica
https://www.readbyqxmd.com/read/28704461/assessing-the-performance-of-remotely-sensed-flooding-indicators-and-their-potential-contribution-to-early-warning-for-leptospirosis-in-cambodia
#8
Julia Ledien, Sopheak Sorn, Sopheak Hem, Rekol Huy, Philippe Buchy, Arnaud Tarantola, Julien Cappelle
Remote sensing can contribute to early warning for diseases with environmental drivers, such as flooding for leptospirosis. In this study we assessed whether and which remotely-sensed flooding indicator could be used in Cambodia to study any disease for which flooding has already been identified as an important driver, using leptospirosis as a case study. The performance of six potential flooding indicators was assessed by ground truthing. The Modified Normalized Difference Water Index (MNDWI) was used to estimate the Risk Ratio (RR) of being infected by leptospirosis when exposed to floods it detected, in particular during the rainy season...
2017: PloS One
https://www.readbyqxmd.com/read/28703142/new-uk-graduates-knowledge-of-training-and-service-provision-within-restorative-dentistry-a-survey
#9
A S Kalsi, S Kochhar, N J Lewis, K W Hemmings
Objective To assess new UK graduates' knowledge of training and service provision within restorative dentistry.Design A national descriptive cross-sectional survey.Subjects and methods An online survey assessing clinicians' knowledge of restorative dentistry, who had graduated within the last four years in the UK, was distributed across the UK via postgraduate dental deaneries. One-hundred responses were accepted as a sample of a potential population of 4,000.Main outcome measure How well respondents understood the service provision and training aspects of the specialty of restorative dentistry...
June 9, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28700459/the-microbiome-in-posttraumatic-stress-disorder-and-trauma-exposed-controls-an-exploratory-study
#10
Sian M J Hemmings, Stefanie Malan-Muller, Leigh L van den Heuvel, Brittany A Demmitt, Maggie A Stanislawski, David G Smith, Adam D Bohr, Christopher E Stamper, Embriette R Hyde, James T Morton, Clarisse A Marotz, Philip H Siebler, Maarten Braspenning, Wim Van Criekinge, Andrew J Hoisington, Lisa A Brenner, Teodor T Postolache, Matthew B McQueen, Kenneth S Krauter, Rob Knight, Soraya Seedat, Christopher A Lowry
OBJECTIVE: Inadequate immunoregulation and elevated inflammation may be risk factors for posttraumatic stress disorder (PTSD), and microbial inputs are important determinants of immunoregulation; however, the association between the gut microbiota and PTSD is unknown. This study investigated the gut microbiome in a South African sample of PTSD-affected individuals and trauma-exposed (TE) controls, to identify potential differences in microbial diversity or microbial community structure...
July 11, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28697494/diet-and-activity-of-macaca-assamensis-in-wild-and-semi-provisioned-groups-in-shivapuri-nagarjun-national-park-nepal
#11
Sabina Koirala, Mukesh K Chalise, Hem Bahadur Katuwal, Raju Gaire, Bishnu Pandey, Hideshi Ogawa
Studying the behavioural flexibility and adaptability of macaques to different habitats is one approach to designing a conservation plan. To determine the activity budget and feeding behaviour and evaluate the effects of seasonality in wild and human- altered habitats of Assamese macaques (Macaca assamensis), we conducted this study in the Nagarjun forest of Shivapuri-Nagarjun National Park (SNNP) in central Nepal. We also updated the list of plant food items of Assamese macaques in the SNNP. Using scan and all-occurrence sampling, we recorded the diets and activities of Assamese macaques in 2 social groups, a wild-feeding group (WG) and a semi-provisioned group (SPG), throughout the year from August 2013 to July 2014...
July 12, 2017: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/28695248/divergent-effects-of-anesthetics-on-lipid-bilayer-properties-and-sodium-channel-function
#12
REVIEW
Karl F Herold, Olaf S Andersen, Hugh C Hemmings
General anesthetics revolutionized medicine by allowing surgeons to perform more complex and much longer procedures. This widely used class of drugs is essential to patient care, yet their exact molecular mechanism(s) are incompletely understood. One early hypothesis over a century ago proposed that nonspecific interactions of anesthetics with the lipid bilayer lead to changes in neuronal function via effects on membrane properties. This model was supported by the Meyer-Overton correlation between anesthetic potency and lipid solubility and despite more recent evidence for specific protein targets, in particular ion-channels, lipid bilayer-mediated effects of anesthetics is still under debate...
July 10, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28693524/national-consensus-on-communication-in-prehospital-trauma-care-the-denim-study
#13
Annelieke Maria Karien Harmsen, Leo Maria George Geeraedts, Georgios Fredericus Giannakopoulos, Maartje Terra, Herman M T Christiaans, Lidwine Brigitta Mokkink, Frank Willem Bloemers
BACKGROUND: In the Netherlands prehospital trauma care is provided by emergency medical services (EMS) nurses. This care is extended by Physician staffed Helicopter Emergency Medical Services (P-HEMS) for the more severely injured patient. Prehospital communication is a factor of influence on the identification of these patients and the dispatch of P-HEMS. Though prehospital communication it is often perceived to be incomplete and unstructured. To elucidated factors of influence on prehospital triage and the identification of the severely injured patient a Delphi study was performed...
July 11, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28693491/hypoxia-and-hypotension-in-patients-intubated-by-physician-staffed-helicopter-emergency-medical-services-a-prospective-observational-multi-centre-study
#14
Geir Arne Sunde, Mårten Sandberg, Richard Lyon, Knut Fredriksen, Brian Burns, Karl Ove Hufthammer, Jo Røislien, Akos Soti, Helena Jäntti, David Lockey, Jon-Kenneth Heltne, Stephen J M Sollid
BACKGROUND: The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators of care provided by emergency medical services. Excluding cardiac arrests, critical trauma and non-trauma patients remain the two major groups to which helicopter emergency medical services (HEMS) are dispatched. Several studies describe the impact of pre-hospital hypoxia or hypotension on trauma patients, but few studies compare this in trauma and non-trauma patients...
July 11, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28693219/f-18-fluorodeoxyglucose-positron-emission-tomography-for-differential-diagnosis-and-prognosis-prediction-of-vascular-tumors
#15
Won Woo Lee, Young So, Seo Young Kang, Min-Kyung So, Haeryoung Kim, Hyun Woo Chung, Wan Seop Kim, Sang Eun Kim
The spectrum of vascular tumors ranges from hemangioma (HEM), to epithelioid hemangioendothelioma (EHE) and to angiosarcoma (AS). To the best of our knowledge, the usefulness of F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for vascular tumors has never been comprehensively studied. The present study investigated the usefulness of FDG-PET for pathologically diagnosed vascular tumors. The present study included 26 patients with vascular tumor (male:female, 17:9; age, 60.9±14.4 years; 7 HEM, 6 EHE and 13 AS) who underwent FDG-PET between January 2007 and May 2014 at the Seoul National University Bundang Hospital (Seongnam, Korea) and Konkuk University Medical Center, (Seoul, Korea)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28689704/glycated-hemoglobin-albuminuria-and-surrogate-markers-of-macrovascular-disease-the-guangzhou-biobank-cohort-study-cardiovascular-disease-subcohort
#16
Konstantinos A Toulis, Chao Q Jiang, Karla Hemming, Krishnarajah Nirantharakumar, Kar K Cheng, Tai H Lam, G Neil Thomas
OBJECTIVES: To explore the clinical utility of glycated hemoglobin (A1C) levels as an early marker of albuminuria, macrovascular disease and subclinical cardiovascular disease in comparison to fasting and postprandial glucose levels in a well-characterized Chinese population with no history of diabetes. METHODS: The study population consisted of 1223 individuals who were enrolled in the Guangzhou Biobank Cohort Study, Cardiovascular Disease Subcohort, and who had undergone oral glucose tolerance tests...
July 6, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28683363/association-between-markers-of-arterial-stiffness-and-atrial-fibrillation-in-the-circulatory-risk-in-communities-study-circs
#17
Renzhe Cui, Kazumasa Yamagishi, Isao Muraki, Mina Hayama-Terada, Mitsumasa Umesawa, Hironori Imano, Yuanying Li, Ehab S Eshak, Tetsuya Ohira, Masahiko Kiyama, Takeo Okada, Akihiko Kitamura, Takeshi Tanigawa, Hiroyasu Iso
BACKGROUND AND AIMS: Limited evidence is available on the association between markers of arterial stiffness and the prevalence of atrial fibrillation among Asian populations. Therefore, we examined those associations in the Japanese population. METHODS: We conducted a cross-sectional population-based study of 4264 men and women aged 40-79 years. The augmentation index (AI), a marker of arterial stiffness, was calculated as the ratio of central pulse pressure/brachial pulse pressure, where the AI and central aortic pressure were measured by an automated tonometer: the HEM-9000AI device (Omron Healthcare co...
June 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28682509/prospective-symbiosis-of-green-chemistry-and-energetic-materials
#18
Ilya V Kuchurov, Mikhail N Zharkov, Leonid L Fershtat, Nina N Makhova, Sergei G Zlotin
A global increase in the environmental pollution demands the development of new "cleaner" chemical processes. Among urgent improvements, replacement of traditional hydrocarbon-derived toxic organic solvents with neoteric solvents less harmful for the environment is one of the most vital issues. Due to favorable combination of unique properties, ionic liquids (ILs), dense gases, and supercritical fluids (SCFs) have gained considered attention as suitable green chemistry media for preparation and modification of important chemical compounds and materials...
July 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28681198/childhood-maltreatment-and-hiv-associated-neurocognitive-disorders-share-similar-pathophysiology-a-potential-sensitisation-mechanism
#19
Jacqueline S Womersley, Soraya Seedat, Sian M J Hemmings
HIV-associated neurocognitive disorders (HAND) are increasingly prevalent despite the use of antiretroviral therapies. Previous research suggests that individual host factors play an important role in determining susceptibility to HAND. In this review, we propose that childhood trauma (CT) and HAND share several common aetiological mechanisms, namely hypothalamic-pituitary-adrenal axis dysregulation, neuroinflammation and oxidative stress. These convergent and consequent mechanisms may translate into an increased risk of developing HAND in individuals who have experienced early life stress...
July 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28679023/notable-drug-drug-interaction-between-etizolam-and-itraconazole-in-poor-metabolizers-of-cytochrome-p450-2c19
#20
Takehito Yamamoto, Kenichi Furihata, Akihiro Hisaka, Takashi Moritoyo, Kazuaki Ogoe, Shizuko Kusayama, Keiju Motohashi, Akiko Mori, Takeshi Iwatsubo, Hiroshi Suzuki
In this study, impact of a polymorphism of CYP2C19 on drug-drug interaction (DDI) was examined for etizolam. The effect of itraconazole (a strong CYP3A inhibitor) on the pharmacokinetics of etizolam (a substrate of CYP2C19 and CYP3A) was assessed in both extensive metabolizers (EMs) and poor metabolizers (PMs) of CYP2C19. Sixteen participants (8 EMs and 8 PMs) received a single oral dose of etizolam (0.25 mg) on day 1. The participants ingested itraconazole (200 mg twice a day) on days 2-5. On day 5, participants received an oral dose of etizolam (0...
July 5, 2017: Journal of Clinical Pharmacology
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