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https://www.readbyqxmd.com/read/28217519/prevalence-of-vitamin-d-deficiency-and-associated-risk-factors-among-children-residing-at-high-altitude-in-shimla-district-himachal-pradesh-india
#1
Umesh Kapil, Ravindra Mohan Pandey, Ravinder Goswami, Brij Sharma, Neetu Sharma, Lakshmy Ramakrishnan, Gajendra Singh, Neha Sareen, Hem Chandra Sati, Aakriti Gupta, Nighat Yaseen Sofi
INTRODUCTION: Vitamin D is important for bone development in children. A high prevalence of Vitamin D deficiency (VDD) has been documented from different parts of India. However, limited data are available on VDD among children residing at high altitude region of country. OBJECTIVES: To assess the prevalence of VDD and associated risk factors among children in the age group of 6-18 years in Shimla, Himachal Pradesh. METHODS: A community-based cross-sectional study was conducted in the year 2014-2015...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28210554/preoperative-psychosocial-characteristics-may-predict-body-image-and-sexuality-two-years-after-risk-reducing-mastectomy-a-prospective-study
#2
Dmytro Unukovych, Hemming Johansson, Yvonne Brandberg
BACKGROUND: Risk-reducing mastectomy (RRM) in patients at high risk has become more available and the rates of both bilateral (BRRM) and contralateral (CRRM) procedures are increasing. For women opting for RRM, psychosocial well-being, body image and sexuality are known to be important patient-reported outcomes. The aim of the present study was to investigate baseline health-related quality of life (HRQoL) and emotional distress (anxiety and depression) as predictors of body image and sexuality two years after RRM in women undergoing CRRM and BRRM...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28203735/intraoperative-tranexamic-acid-use-in-major-spine-surgery-in-adults-a-multicentre-randomized-placebo-controlled-trial%C3%A2
#3
M J Colomina, M Koo, M Basora, J Pizones, L Mora, J Bagó
No abstract text is available yet for this article.
March 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28202487/migrated-hem-o-lok-clips-in-the-ureter-a-rare-cause-of-recurrent-urinary-tract-infection
#4
Prashant Shrivastava, Brusabhanu Nayak, Prabhjot Singh
Erosion of surgical materials into the adjacent organs following surgical procedures is a rare complication. Migrations of these surgical materials into the urinary tract like pelvicalyceal system, ureter and bladder have been reported following various urological procedures. We present a case of migrated Hem-o-Lok clips into the ureter following a laparoscopic partial nephrectomy for angiomyolipoma of the left kidney presented with recurrent urinary tract infection. The case was managed with ureteroscopic removal of clips...
February 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28196902/hyaluronidase-2-deficiency-causes-increased-mesenchymal-cells-congenital-heart-defects-and-heart-failure
#5
Biswajit Chowdhury, Bo Xiang, Michelle Liu, Richard Hemming, Vernon W Dolinsky, Barbara Triggs-Raine
BACKGROUND: Hyaluronan (HA) is required for endothelial-to-mesenchymal transition and normal heart development in the mouse. Heart abnormalities in hyaluronidase 2 (HYAL2)-deficient (Hyal2(-)(/-) ) mice and humans suggested removal of HA is also important for normal heart development. We have performed longitudinal studies of heart structure and function in Hyal2(-/-) mice to determine when, and how, HYAL2 deficiency leads to these abnormalities. METHODS AND RESULTS: Echocardiography revealed atrial enlargement, atrial tissue masses, and valvular thickening at 4 weeks of age, as well as diastolic dysfunction that progressed with age, in Hyal2(-/-) mice...
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28192440/helicopter-emergency-medical-services-in-major-incident-management-a-national-norwegian-cross-sectional-survey
#6
Anne Siri Johnsen, Stephen J M Sollid, Trond Vigerust, Morten Jystad, Marius Rehn
OBJECTIVE: Helicopter Emergency Medical Services (HEMS) aim to bring a highly specialised crew to the scene of major incidents for triage, treatment and transport. We aim to describe experiences made by HEMS in Norway in the management of major incidents. DESIGN: Doctors, rescue paramedics and pilots working in Norwegian HEMS and Search and Rescue Helicopters (SAR) January 1st 2015 were invited to a cross-sectional study on experiences, preparedness and training in major incident management...
2017: PloS One
https://www.readbyqxmd.com/read/28190762/optimal-fractionation-of-preoperative-radiotherapy-and-timing-to-surgery-for-rectal-cancer-stockholm-iii-a-multicentre-randomised-non-blinded-phase-3-non-inferiority-trial
#7
Johan Erlandsson, Torbjörn Holm, David Pettersson, Åke Berglund, Björn Cedermark, Calin Radu, Hemming Johansson, Mikael Machado, Fredrik Hjern, Olof Hallböök, Ingvar Syk, Bengt Glimelius, Anna Martling
BACKGROUND: Radiotherapy reduces the risk of local recurrence in rectal cancer. However, the optimal radiotherapy fractionation and interval between radiotherapy and surgery is still under debate. We aimed to study recurrence in patients randomised between three different radiotherapy regimens with respect to fractionation and time to surgery. METHODS: In this multicentre, randomised, non-blinded, phase 3, non-inferiority trial (Stockholm III), all patients with a biopsy-proven adenocarcinoma of the rectum, without signs of non-resectability or distant metastases, without severe cardiovascular comorbidity, and planned for an abdominal resection from 18 Swedish hospitals were eligible...
February 9, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28179180/developing-a-3-choice-serial-reaction-time-task-for-examining-neural-and-cognitive-function-in-an-equine-model
#8
Kirsty Roberts, Andrew J Hemmings, Sebastian D McBride, Matthew O Parker
BACKGROUND: Large animal models of human neurological disorders are advantageous compared to rodent models due to their neuroanatomical complexity, longevity and their ability to be maintained in naturalised environments. Some large animal models spontaneously develop behaviours that closely resemble the symptoms of neural and psychiatric disorders. The horse is an example of this; the domestic form of this species consistently develops spontaneous stereotypic behaviours akin to the compulsive and impulsive behaviours observed in human neurological disorders such as Tourette's syndrome...
February 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28177891/tumour-infiltrating-regulatory-t-cell-density-before-neoadjuvant-chemoradiotherapy-for-rectal-cancer-does-not-predict-treatment-response
#9
Melanie J McCoy, Chris Hemmings, Chidozie C Anyaegbu, Stephanie J Austin, Tracey F Lee-Pullen, Timothy J Miller, Max K Bulsara, Nikolajs Zeps, Anna K Nowak, Richard A Lake, Cameron F Platell
Neoadjuvant (preoperative) chemoradiotherapy (CRT) decreases the risk of rectal cancer recurrence and reduces tumour volume prior to surgery. However, response to CRT varies considerably between individuals and factors associated with response are poorly understood. Foxp3+ regulatory T cells (Tregs) inhibit anti-tumour immunity and may limit any response to chemotherapy and radiotherapy. We have previously reported that a low density of Tregs in the tumour stroma following neoadjuvant CRT for rectal cancer is associated with improved tumour regression...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28161568/evidence-of-a-hard-selective-sweep-for-artemisinin-resistant-plasmodium-falciparum
#10
Elizabeth Hemming-Schroeder, Eugenia Lo
No abstract text is available yet for this article.
February 1, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28156530/evaluation-of-hematologist-oncologist-attributes-by-physicians-and-patients-a-survey-study
#11
Cory Patrick, Rakesh Singal, Damien Mikael Hansra
: 124 Background: We aim to compare what attributes are important to hematology/oncology (hem/onc) physicians (MD) and patients (pts). METHODS: IRB approval obtained. Pts and MDs at an academic tertiary care medical center were enrolled to complete a survey. Demographics include: age, gender, race, and ethnicity. Clinical info collected: cancer subtype and treating MD. Survey consisted of 5 questions assessing opinions on physician attributes. Patients were asked: "It is important that my doctor" is friendly, is empathetic, is knowledgeable, well dressed, and engaged in research...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156528/evaluation-of-patient-s-versus-hematologist-oncologist-s-office-visit-agenda
#12
Kaitlin McIntyre, Rakesh Singal, Damien Mikael Hansra
: 125 Background: Few studies have been reported in oncology regarding elements of physician agenda. We aim to compare elements of a doctor office visit agenda between hem/onc physicians (MD) and patients (pts). METHODS: Pts and MDs were enrolled to completed a five question survey. Pts were asked: "My doctor" Focuses more on quantity of life and less on quality of life, spends enough time with me, addresses symptoms, addresses chemo side effects, and addresses prognosis...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154162/outcomes-of-physician-staffed-versus-non-physician-staffed-helicopter-transport-for-st-elevation-myocardial-infarction
#13
Sverrir I Gunnarsson, Joseph Mitchell, Mary S Busch, Brenda Larson, S Michael Gharacholou, Zhanhai Li, Amish N Raval
BACKGROUND: The effect of physician-staffed helicopter emergency medical service (HEMS) on ST-elevation myocardial infarction (STEMI) patient transfer is unknown. The purpose of this study was to evaluate the characteristics and outcomes of physician-staffed HEMS (Physician-HEMS) versus non-physician-staffed (Standard-HEMS) in patients with STEMI. METHODS AND RESULTS: We studied 398 STEMI patients transferred by either Physician-HEMS (n=327) or Standard-HEMS (n=71) for primary or rescue percutaneous coronary intervention at 2 hospitals between 2006 and 2014...
February 2, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28146381/reply-racial-disparities-in-acute-respiratory-distress-syndrome-mortality
#14
Christian Bime, Bhupinder Natt, Hem Desai, Chithra Poongkunran, Mark Borgstrom
No abstract text is available yet for this article.
February 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28140733/integrated-metabonomic-proteomic-studies-on-blood-enrichment-effects-of-angelica-sinensis-on-a-blood-deficiency-mice-model
#15
Yongli Hua, Wangling Yao, Peng Ji, Yanming Wei
CONTEXT: Angelica sinensis (Oliv.) Diels (Umbelliferae) (AS) is a well-known Traditional Chinese Medicine (TCM) that enriches and regulates the blood. OBJECTIVE: An integrated metabonomic and proteomic method was developed and applied to study the blood enrichment effects and mechanisms of AS on blood deficiency (BD) mouse model. MATERIALS AND METHODS: Forty mice were randomly divided into the control, BD, High-dose of AS (ASH), Middle-dose of AS (ASM), and Low-dose of AS (ASL) groups...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28134008/prioritising-patient-care
#16
Helge Skirbekk, Marit Helene Hem, Per Nortvedt
BACKGROUND: There is little research comparing clinicians' and managers' views on priority settings in the healthcare services. During research on two different qualitative research projects on healthcare prioritisations, we found a striking difference on how hospital executive managers and clinical healthcare professionals talked about and understood prioritisations. AIM: The purpose of this study is to explore how healthcare professionals in mental healthcare and somatic medicine prioritise their care, to compare different ways of setting priorities among managers and clinicians and to explore how moral dilemmas are balanced and reconciled...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28113600/structural-class-classification-of-3d-protein-structure-based-on-multi-view-2d-images
#17
Chendra Hadi Suryanto, Hiroto Saigo, Kazuhiro Fukui
Computing similarity or dissimilarity between protein structures is an important task in structural biology. Conventional method to compute protein structure dissimilarity requires structural alignment of the proteins. However, defining one best alignment is difficult, especially when the structures are very different. In this paper, we propose a new similarity measure for protein structure comparisons using a set of multi-view 2D images of 3D protein structures. In this approach, each protein structure is represented by a subspace from the image set...
August 29, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28103817/erratum-to-sample-size-calculations-for-cluster-randomised-controlled-trials-with-a-fixed-number-of-clusters
#18
Karla Hemming, Alan J Girling, Alice J Sitch, Jennifer Marsh, Richard J Lilford
No abstract text is available yet for this article.
January 19, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28103520/using-health-promotion-guidelines-for-persons-with-disabilities-to-develop-and-evaluate-a-physical-activity-program-for-individuals-with-multiple-sclerosis-a-feasibility-study
#19
Alicia Dixon-Ibarra, Mara Nery-Hurwit, Simon Driver, Megan MacDonald
The Health Education for Persons with Multiple Sclerosis (HEMS) program was developed in response to the need for interventions aimed at increasing physical activity for individuals with Multiple Sclerosis (MS). It was developed and evaluated using Drum and colleagues (2009) guidelines for implementing health promotion programs for individuals with disabilities. The purpose of this feasibility study is to describe the development, implementation, and evaluation of the HEMS program. Thirteen individuals with MS completed the 8-week health education program...
December 13, 2016: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28103121/comparison-of-helicopter-emergency-medical-services-transport-types-and-delays-on-patient-outcomes-at-two-level-i-trauma-centers
#20
Brodie Nolan, Homer Tien, Bruce Sawadsky, Sandro Rizoli, Amanda McFarlan, Andrea Phillips, Alun Ackery
BACKGROUND: Helicopter emergency medical services (HEMS) have become an engrained component of trauma systems. In Ontario, transportation for trauma patients is through one of three ways: scene call, modified scene call, or interfacility transfer. We hypothesize that differences exist between these types of transports in both patient demographics and patient outcomes. This study compares the characteristics of patients transported by each of these methods to two level 1 trauma centers and assesses for any impact on morbidity or mortality...
January 19, 2017: Prehospital Emergency Care
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