Read by QxMD icon Read

cleft li

P Ha, C Li, B Shi
The purpose of this study was to investigate the key factors in relation to parent satisfaction with the primary repair of paediatric cleft lip. One hundred and ninety-five children born with cleft lip and/or palate aged between 3 months and 1 year were recruited, along with their caregivers. All patients underwent primary cleft lip repair, and a telephone interview was held with their main caregivers at 3 months postoperative. The level of satisfaction with each item included in a simplified Cleft Evaluation Profile was ascertained and recorded...
October 18, 2016: International Journal of Oral and Maxillofacial Surgery
F Li, H-T Wang, Y-Y Chen, W-L Wu, J-Y Liu, J-S Hao, D-Y Luo
This study was performed to investigate the incidence of and risk factors for postoperative cleft relapse and oronasal fistula after Furlow palatoplasty in infants. Sixty-two infants with cleft palate, aged 6-12 months (mean 8.25 months), who underwent cleft repair by Furlow double opposing Z-plasty between March 2012 and August 2014, were enrolled in the study. Risk factors for postoperative cleft relapse and oronasal fistula after Furlow palatoplasty were identified by logistic regression analysis. The incidence rates of cleft relapse at 1 week and oronasal fistula at 3 months after surgery were 24...
October 18, 2016: International Journal of Oral and Maxillofacial Surgery
Lei Cheng, Pin Guo, Peng Jin, Huanting Li, Mingchao Fan, Enyuan Cai
Rathke cleft cysts (RCCs) are nonneoplastic lesions that are thought to be the remnants of Rathke cleft pouch. The authors report a patient presented with a headache and was diagnosed with RCC on imaging. The lesion underwent spontaneous involution. The authors suggest that patients presenting solely with a headache to be treated conservatively, because it is uncertain whether a headache is definitively associated with RCCs and because there is the possibility of spontaneous regression.
October 14, 2016: Journal of Craniofacial Surgery
Li Li, Yang Lu, Min Li, Xunwei Liu, Peng Jin, Lijun Wang, Gang Sun
STUDY DESIGN: A retrospective study. SUMMARY OF BACKGROUND DATA: Percutaneous vertebroplasty (PV) changes mechanical stress of vertebral column and can cause recurrent pain at the treated level. However, there were a few reports on the therapeutic effects of the repeat PV for patients with recurrent pain at the treated level. OBJECTIVE: To evaluate the therapeutic effects of repeat PV at previously treated vertebral level for patients with osteoporotic vertebral compression fractures (OVCFs) having recurrent pain after initial PV...
November 2016: Clinical Spine Surgery
Bin Wang, Yuxi Zhou, Song Leng, Liyuan Zheng, Hong Lv, Fei Wang, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurodevelopment disorder characterized by reading disabilities without apparent etiologies. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a structural craniofacial malformation featured by isolated orofacial abnormalities. Despite substantial phenotypic differences, potential linkage between these two disorders has been suggested as prevalence of DD among NSCL/P patients was much higher than that in general populations. Previous neuroimaging studies observed impaired short-term memory in patients with DD and NSCL/P, respectively...
October 13, 2016: Journal of Human Genetics
Zhang Xuan, Yang Zhongpeng, Guo Yanjun, Dai Jiaqi, Zhu Yuchi, Shi Bing, Li Chenghao
OBJECTIVE: To assess the association between maternal active cigarette smoking and the risk of oral clefts in the offspring. STUDY DESIGN: Oral clefts are divided into three subgroups: total clefts, cleft lip with or without cleft palate (CL ± P), and cleft palate only (CP). Data from studies on different levels of smoking were gathered to examine the dose-response effect. RESULTS: The present meta-analysis included 29 case-control and cohort studies through Cochrane, PubMed, and Ovid Medline searches...
August 18, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Liqi Li, Lishu Liao, Yuxiang Zhong, Yuangui Li, Li Xiang, Wanshan Li
PURPOSE: To evaluate postoperative variation trends of unilateral cleft lip by stages, and to analyze influential factors of nasolabial symmetry. MATERIALS AND METHODS: A total of 145 patients with unilateral cleft lip were treated by the modified Mohler or Tennison-Randall technique, and received routine anti-scarring treatment postoperatively. Photogrammetry was applied to respectively measure 5 indices by stages preoperatively, the first week (1 w), the third month (3 m), the sixth month (6 m), and the first year (1 y) postoperatively...
September 9, 2016: Journal of Cranio-maxillo-facial Surgery
Jian Zhang, Ziyi Liu, Tingting Zhang, Zhuchun Lin, Zhenzu Li, Aizhen Zhang, Xiaoyang Sun, Jiangang Gao
Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development. Our previous study showed that the loss of LOXL3 resulted in a severe cleft palate and spinal deformity. In this study, we investigated a possible role for LOXL3 in mouse embryonic lung development. LOXL3-deficient mice displayed reduced lung volumes and weights, diminished saccular spaces, and deformed and smaller thoracic cavities...
2016: Scientific Reports
Fang Tong, Yue Liang, Muhammad Fasahat Khan, Lin Zhang, Wenhe Li, Mohammed Mahmoodurrahman, Yiwu Zhou
BACKGROUND: Branchial cleft anomalies constitute a frequently encountered and commonly non-lethal disease in otolaryngology, and result from aberrant embryonic development. The third branchial cleft fistula is one of the four known specific types of branchial cleft anomalies, and always presents as recurrent neck abscess and suppurative thyroiditis. Here, we report an unexpected death due to severe neck infection following a third branchial cleft fistula. CASE PRESENTATION: A 19-year-old man was sent to the hospital with a 1-week history of recurrent left-sided neck abscess, and was scheduled for incision and drainage of the abscess...
2016: Diagnostic Pathology
Li Peng, Kimberly Cook, Linda Xu, Li Cheng, Melissa Damschroder, Changshou Gao, Herren Wu, William F Dall'Acqua
Inhibitors of tumor necrosis factor-α converting enzyme (TACE) have potential as therapeutics for various diseases. Many small molecule inhibitors, however, exhibit poor specificity profiles because they target the highly conserved catalytic cleft of TACE. We report for the first time the molecular interaction of a highly specific anti-TACE antagonistic antibody (MEDI3622). We characterized the binding of MEDI3622 using mutagenesis, as well as structural modeling and docking approaches. We show that MEDI3622 recognizes a unique surface loop of sIVa-sIVb β-hairpin on TACE M-domain, but does not interact with the conserved catalytic cleft or its nearby regions...
September 9, 2016: MAbs
Jun-Zi Yingwang, Shun-Yao Shen, Biao Li, Hao Sun, Xu-Dong Wang
PURPOSE: To establish a three dimensional spacial measurement method to analyze the short-term stability of maxilla after orthognathic surgery in cleft lip and palate patients. METHODS: Twenty-five patients with maxillary hypoplasia secondary to cleft lip and palate seeking for orthognathic surgery were included in this study between January 2008 and September 2012. The spiral CT scan for the skull were taken 6 weeks preoperatively (T0), 4 days postoperatively (T1),3 months postoperatively (T2), and 6 months postoperatively (T3) and collected...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Bingqing Li, Ning Li, Yingying Yue, Xiuhua Liu, Yan Huang, Lichuan Gu, Sujuan Xu
Iron acquisition by siderophores is critical for the survival of most bacteria. Enterobactin is a kind of catechol siderophore that exhibits the highest affinity to iron atoms secreted by E. coli and several other species of Enterobacteriaceae. The periplasmic binding protein (PBP) FepB can transport ferric-enterobactin (Fe-Ent) from the outer membrane to the membrane-associated ATP-binding cassette transport system in E. coli. To elucidate this process, we solved the crystal structure of FepB in complex with Fe-Ent at a resolution of 1...
September 23, 2016: Biochemical and Biophysical Research Communications
Xiaoqing Yin, Lan Ma, Yuan Li, Min Xu, Wei Wang, Hua Wang, Hua Yuan, Yifei Du, Sheng Li, Junqing Ma, Hongbing Jiang, Lin Wang, Weibing Zhang, Pan Yongchu
OBJECTIVE: Previous genome-wide association studies (GWAS) identified a region near MAFB at chr20q12 associated with non-syndromic orofacial clefts (NSOC) susceptibility. However, whether other SNPs in this area could independently contribute to non-syndromic orofacial clefts in Chinese populations remained obscure. MATERIALS AND METHODS: We selected 24 SNPs based on a haplotype-tagging SNP strategy and evaluated their associations with risk of non-syndromic orofacial clefts in a large scale two-stage case-control study with 1,278 cases and 1,295 controls...
August 18, 2016: Oral Diseases
Dandan Li, Hongchuang Zhang, Lan Ma, Yue Han, Min Xu, Zhendong Wang, Hongbing Jiang, Weibing Zhang, Lin Wang, Yongchu Pan
We hypothesized that microRNA binding site single nucleotide polymorphisms (SNPs) in fibroblast growth factors (FGFs) and their receptor genes (FGFRs) may affect microRNA and mRNA interactions and are thereby associated with susceptibility of non-syndromic orofacial cleft (NSOC). Ten SNPs among the FGF and FGFR genes were selected and their associations with NSOC susceptibility were investigated in a case-control study of 602 patients with NSOC and 605 healthy controls. FGF2/rs1048201, FGF5/rs3733336 and FGF9/rs546782 showed suggestive association with NSOC susceptibility...
2016: Scientific Reports
Li-lai Zha, Pei-jian Tong, Lu-wei Xia, Lu-jiang Rong, Yun-long Lou
OBJECTIVE: To explore the diagnostic value of the radiologic characteristics of osteoporotic Kummell's disease. METHODS: Total 16 patients with pathologically confirmed osteoporotic Kummell's diseases were reviewed from May 2010 to May 2012, including 4 males and 12 females with the mean age of 73.4 years (ranged, 67 to 83 years old). Radiologic imagings of all patients, including X-ray, CT and MRI, were analyzed retrospectively. RESULTS: Intravertebral linear clefts could be seen on the AP and lateral X-ray films of vertebrae...
May 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yongzhong Wang, Zhen Fan, Lei Shao, Xiaowei Kong, Xianjuan Hou, Dongrui Tian, Ying Sun, Yazhong Xiao, Li Yu
Owing to peculiar properties of nanobody, including nanoscale size, robust structure, stable and soluble behaviors in aqueous solution, reversible refolding, high affinity and specificity for only one cognate target, superior cryptic cleft accessibility, and deep tissue penetration, as well as a sustainable source, it has been an ideal research tool for the development of sophisticated nanobiotechnologies. Currently, the nanobody has been evolved into versatile research and application tool kits for diverse biomedical and biotechnology applications...
2016: International Journal of Nanomedicine
Xiaoran Ma, Yue Wing Li, Lian Ma, Bradley McPherson
OBJECTIVES: This study examined the auditory status of Chinese children with nonsyndromic cleft lip/palate (NSCL/P), investigated factors associated with peripheral hearing loss and compared results with earlier studies in western countries. METHODS: Case history profiles and audiological data from 148 Chinese children with NSCL/P, aged between 6 and 15 years, who attended the Cleft Lip and Palate Clinic Center in a major Chinese urban hospital from July 2012 to September 2013 were acquired...
September 2016: International Journal of Pediatric Otorhinolaryngology
Jijun Zou, Jingyun Li, Jun Li, Chenbo Ji, Qingping Li, Xirong Guo
OBJECTIVE: The aim of this study was to determine the expression profile of plasma microRNAs in nonsyndromic cleft lip (NSCL) and their clinical significance as biomarkers. METHODS: Agilent human miRNA microarray chips were used to analyze three NSCL plasma samples (mixed as CL group) and three normal plasma samples (mixed as Control group). Six selected plasma miRNAs were validated using qRT-PCR between another 13 CL and 11 healthy children. The receiver operating characteristic (ROC) curve analysis was applied for three elevated miRNAs, miR-16-2-3p, miR-365a-3p and miR-877-5p...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Dengwei He, Weiyang Yu, Zhenzhong Chen, Liangchen Li, Kejun Zhu, Shunwu Fan
In this review, we explored the progress of the pathogenesis of Kümmell's disease intravertebral vacuum. Using different expressions of the same disease including 'Kümmell's disease', 'avascular necrosis after vertebral compression fracture (VCF)', 'post-traumatic vertebral osteonecrosis', 'vertebral pseudarthrosis', 'intravertebral vacuum (cleft or gas)', 'delayed vertebral collapse', 'VCF nonunion', and by conducting a search of the PubMed database, we analyzed the results to examine the pathogenesis of the intravertebral vacuum of Kümmell's disease after referring to pertinent literature on intravertebral vacuum of ischemic necrosis after VCF, and exploring the progress of pathogenesis of this disease...
August 2016: Experimental and Therapeutic Medicine
Rui Xu, Ying Lian, Wen Xian Li
OBJECTIVE: Flexible laryngeal mask airways (FLMAs) have been widely used in thyroidectomy as well as cleft palate, nasal, upper chest, head and neck oncoplastic surgeries. This systematic review aims to compare the incidence of airway complications that occur during and after general anesthesia when using the FLMA and endotracheal intubation (ETT). We performed a quantitative meta-analysis of the results of randomized trials. METHODS: A comprehensive search of the PubMed, Embase and Cochrane Library databases was conducted using the key words "flexible laryngeal mask airway" and "endotracheal intubation"...
2016: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"