keyword
MENU ▼
Read by QxMD icon Read
search

cleft li

keyword
https://www.readbyqxmd.com/read/27920087/structural-visualization-of-the-p53-rna-polymerase-ii-assembly
#1
Sameer K Singh, Zhen Qiao, Lihua Song, Vijay Jani, William Rice, Edward Eng, Robert A Coleman, Wei-Li Liu
The master tumor suppressor p53 activates transcription in response to various cellular stresses in part by facilitating recruitment of the transcription machinery to DNA. Recent studies have documented a direct yet poorly characterized interaction between p53 and RNA polymerase II (Pol II). Therefore, we dissected the human p53/Pol II interaction via single-particle cryo-electron microscopy, structural docking, and biochemical analyses. This study reveals that p53 binds Pol II via the Rpb1 and Rpb2 subunits, bridging the DNA-binding cleft of Pol II proximal to the upstream DNA entry site...
December 5, 2016: Genes & Development
https://www.readbyqxmd.com/read/27917834/the-crystal-structure-of-the-endoglucanase-cel10-a-family-8-glycosyl-hydrolase-from-klebsiella-pneumoniae
#2
Ayman Attigani, Lifang Sun, Qing Wang, Yadan Liu, Dingping Bai, Shengping Li, Xiaohong Huang
Cellulases are produced by microorganisms that grow on cellulose biomass. Here, a cellulase, Cel10, was identified in a strain of Klebsiella pneumoniae isolated from Chinese bamboo rat gut. Analysis of substrate specificity showed that Cel10 is able to hydrolyze amorphous carboxymethyl cellulose (CMC) and crystalline forms of cellulose (Avicel and xylan) but is unable to hydrolyze p-nitrophenol β-D-glucopyranoside (p-NPG), proving that Cel10 is an endoglucanase. A phylogenetic tree analysis indicates that Cel10 belongs to the glycoside hydrolase 8 (GH8) subfamily...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27889096/novel-functional-properties-of-drosophila-cns-glutamate-receptors
#3
Yan Li, Poorva Dharkar, Tae-Hee Han, Mihaela Serpe, Chi-Hon Lee, Mark L Mayer
Phylogenetic analysis reveals AMPA, kainate, and NMDA receptor families in insect genomes, suggesting conserved functional properties corresponding to their vertebrate counterparts. However, heterologous expression of the Drosophila kainate receptor DKaiR1D and the AMPA receptor DGluR1A revealed novel ligand selectivity at odds with the classification used for vertebrate glutamate receptor ion channels (iGluRs). DKaiR1D forms a rapidly activating and desensitizing receptor that is inhibited by both NMDA and the NMDA receptor antagonist AP5; crystallization of the KaiR1D ligand-binding domain reveals that these ligands stabilize open cleft conformations, explaining their action as antagonists...
November 21, 2016: Neuron
https://www.readbyqxmd.com/read/27876010/a-discriminant-analysis-prediction-model-of-non-syndromic-cleft-lip-with-or-without-cleft-palate-based-on-risk-factors
#4
Huixia Li, Miyang Luo, Jiayou Luo, Jianfei Zheng, Rong Zeng, Qiyun Du, Junqun Fang, Na Ouyang
BACKGROUND: A risk prediction model of non-syndromic cleft lip with or without cleft palate (NSCL/P) was established by a discriminant analysis to predict the individual risk of NSCL/P in pregnant women. METHODS: A hospital-based case-control study was conducted with 113 cases of NSCL/P and 226 controls without NSCL/P. The cases and the controls were obtained from 52 birth defects' surveillance hospitals in Hunan Province, China. A questionnaire was administered in person to collect the variables relevant to NSCL/P by face to face interviews...
November 23, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27875514/domino-flaps-for-repairing-of-secondary-bilateral-cleft-lip-with-severe-columella-deformity
#5
Jiao Wei, Cheng-An Chiang, Da Zhou, Qingfeng Li, Kai Liu
The patients with secondary bilateral cleft lip and nasal deformity always suffer from a serious part of the horizontal and vertical soft tissue deficiencies in the upper lip and nose, especially the columella. Normally, the Abbe flap is used to increase the soft tissue volume of upper lip. However, how to reconstruct the sever columella deficient, how to make full use of the Abbe flap and the remaining soft tissue of the upper lip, are always the problems that need to be solved by plastic surgeons. Twenty-nine patients with secondary bilateral cleft lip and severe columella deficiency were simultaneously reconstructed with several local flaps like dominos that was called "Domino sliding flaps...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27871707/cone-beam-computed-tomography-synthesized-cephalometric-study-of-operated-unilateral-cleft-lip-and-palate-and-noncleft-children-with-class-iii-skeletal-relationship
#6
Yifan Lin, Zhen Fu, Lian Ma, Weiran Li
INTRODUCTION: Our objective was to compare the craniofacial hard and soft tissue characteristics between children with operated unilateral cleft lip and palate (UCLP) and children with noncleft lip and palate (non-CLP) with a Class III skeletal relationship. METHODS: The study sample consisted of 30 subjects (18 boys, 12 girls; mean age, 10.21 years) affected by UCLP and 30 non-CLP subjects (17 boys, 13 girls; mean age, 10.19 years) as the control group. All subjects were in the mixed dentition with a Class III skeletal relationship...
November 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27863433/assessment-of-differentially-expressed-plasma-micrornas-in-nonsyndromic-cleft-palate-and-nonsyndromic-cleft-lip-with-cleft-palate
#7
Jingyun Li, Jijun Zou, Qian Li, Ling Chen, Yanli Gao, Hui Yan, Bei Zhou, Jun Li
Plasma microRNAs (miRNAs) have recently emerged as a new class of regulatory molecules that influence many biological functions. However, the expression profile of plasma microRNAs in nonsyndromic cleft palate (NSCP) or nonsyndromic cleft lip with cleft palate (NSCLP) remains poorly investigated. In this study, we used Agilent human miRNA microarray chips to monitor miRNA levels in three NSCP plasma samples (mixed as the CP group), three NSCLP plasma samples (mixed as the CLP group) and three normal plasma samples (mixed as the Control group)...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27817770/-effect-of-advanced-maternal-age-on-birth-defects-and-postnatal-complications-of-neonates
#8
Zheng Wang, Li Li, Xue-Ya Lei, Jin Xue, Hong-Ying Mi
OBJECTIVE: To investigate the effect of advanced maternal age on birth defects and postnatal complications of neonates. METHODS: Among the 1 109 neonates who were born at The First People's Hospital of Yunnan Province between January 2014 and December 2015, 536 neonates whose mothers were aged ≥35 years were enrolled as advanced age group and 573 neonates whose mothers were aged <35 years were enrolled as appropriate-age group. The incidences of the comorbidities in pregnancy, fetal intrauterine distress, neonatal birth defects, and postnatal complications were compared between the two groups...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27814918/four-tiered-echocardiographic-analysis-approach-for-congenital-mitral-valve-malformations-four-years-of-experience
#9
Feifei Sun, Yixin Chen, Weidong Ren, Ying Zhang, Dan Wu, Xin Chen, Chunyan Ma, Dongyu Li
BACKGROUND: Traditional methods of describing and classifying congenital mitral valve malformations (CMVMs) often lack specificity and scientificity. Thus, documentation is incomplete, especially in terms of ultrasound findings. METHODS: Data were collected from 436 patients (mean age, 36.6±26.8years; male 47.9%), each subjected to echocardiographic evaluation of CMVM. Valvar characteristics were studied and analyzed via a four-tiered echocardiographic analysis (FTEA) approach: (1) supravalvular region and annulus, (2) valvar leaflets and commissures, (3) chordae tendineae, and (4) papillary muscles...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27769737/parent-satisfaction-with-primary-repair-of-paediatric-cleft-lip-in-southwest-china
#10
P Ha, C Li, B Shi
The purpose of this study was to investigate the key factors in relation to parent satisfaction with the primary repair of paediatric cleft lip. One hundred and ninety-five children born with cleft lip and/or palate aged between 3 months and 1 year were recruited, along with their caregivers. All patients underwent primary cleft lip repair, and a telephone interview was held with their main caregivers at 3 months postoperative. The level of satisfaction with each item included in a simplified Cleft Evaluation Profile was ascertained and recorded...
October 18, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27769736/cleft-relapse-and-oronasal-fistula-after-furlow-palatoplasty-in-infants-with-cleft-palate-incidence-and-risk-factors
#11
F Li, H-T Wang, Y-Y Chen, W-L Wu, J-Y Liu, J-S Hao, D-Y Luo
This study was performed to investigate the incidence of and risk factors for postoperative cleft relapse and oronasal fistula after Furlow palatoplasty in infants. Sixty-two infants with cleft palate, aged 6-12 months (mean 8.25 months), who underwent cleft repair by Furlow double opposing Z-plasty between March 2012 and August 2014, were enrolled in the study. Risk factors for postoperative cleft relapse and oronasal fistula after Furlow palatoplasty were identified by logistic regression analysis. The incidence rates of cleft relapse at 1 week and oronasal fistula at 3 months after surgery were 24...
October 18, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27755405/spontaneous-involution-of-a-rathke-cleft-cyst
#12
Lei Cheng, Pin Guo, Peng Jin, Huanting Li, Mingchao Fan, Enyuan Cai
Rathke cleft cysts (RCCs) are nonneoplastic lesions that are thought to be the remnants of Rathke cleft pouch. The authors report a patient presented with a headache and was diagnosed with RCC on imaging. The lesion underwent spontaneous involution. The authors suggest that patients presenting solely with a headache to be treated conservatively, because it is uncertain whether a headache is definitively associated with RCCs and because there is the possibility of spontaneous regression.
October 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27755200/repeat-percutaneous-vertebroplasty-for-recurrent-pain-arising-from-previously-treated-vertebrae-in-patients-with-osteoporotic-vertebral-compression-fractures
#13
Li Li, Yang Lu, Min Li, Xunwei Liu, Peng Jin, Lijun Wang, Gang Sun
STUDY DESIGN: A retrospective study. SUMMARY OF BACKGROUND DATA: Percutaneous vertebroplasty (PV) changes mechanical stress of vertebral column and can cause recurrent pain at the treated level. However, there were a few reports on the therapeutic effects of the repeat PV for patients with recurrent pain at the treated level. OBJECTIVE: To evaluate the therapeutic effects of repeat PV at previously treated vertebral level for patients with osteoporotic vertebral compression fractures (OVCFs) having recurrent pain after initial PV...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27734840/genetic-polymorphism-of-nonsyndromic-cleft-lip-with-or-without-cleft-palate-is-associated-with-developmental-dyslexia-in-chinese-school-aged-populations
#14
Bin Wang, Yuxi Zhou, Song Leng, Liyuan Zheng, Hong Lv, Fei Wang, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurodevelopment disorder characterized by reading disabilities without apparent etiologies. Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a structural craniofacial malformation featured by isolated orofacial abnormalities. Despite substantial phenotypic differences, potential linkage between these two disorders has been suggested as prevalence of DD among NSCL/P patients was much higher than that in general populations. Previous neuroimaging studies observed impaired short-term memory in patients with DD and NSCL/P, respectively...
October 13, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27727103/maternal-active-smoking-and-risk-of-oral-clefts-a-meta-analysis
#15
Zhang Xuan, Yang Zhongpeng, Guo Yanjun, Dai Jiaqi, Zhu Yuchi, Shi Bing, Li Chenghao
OBJECTIVE: To assess the association between maternal active cigarette smoking and the risk of oral clefts in the offspring. STUDY DESIGN: Oral clefts are divided into three subgroups: total clefts, cleft lip with or without cleft palate (CL ± P), and cleft palate only (CP). Data from studies on different levels of smoking were gathered to examine the dose-response effect. RESULTS: The present meta-analysis included 29 case-control and cohort studies through Cochrane, PubMed, and Ovid Medline searches...
August 18, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27720276/variation-trends-of-the-postoperative-outcomes-for-unilateral-cleft-lip-patients-by-modified-mohler-and-tennison-randall-cheiloplasties
#16
Liqi Li, Lishu Liao, Yuxiang Zhong, Yuangui Li, Li Xiang, Wanshan Li
PURPOSE: To evaluate postoperative variation trends of unilateral cleft lip by stages, and to analyze influential factors of nasolabial symmetry. MATERIALS AND METHODS: A total of 145 patients with unilateral cleft lip were treated by the modified Mohler or Tennison-Randall technique, and received routine anti-scarring treatment postoperatively. Photogrammetry was applied to respectively measure 5 indices by stages preoperatively, the first week (1 w), the third month (3 m), the sixth month (6 m), and the first year (1 y) postoperatively...
November 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27645581/loss-of-lysyl-oxidase-like-3-attenuates-embryonic-lung-development-in-mice
#17
Jian Zhang, Ziyi Liu, Tingting Zhang, Zhuchun Lin, Zhenzu Li, Aizhen Zhang, Xiaoyang Sun, Jiangang Gao
Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development. Our previous study showed that the loss of LOXL3 resulted in a severe cleft palate and spinal deformity. In this study, we investigated a possible role for LOXL3 in mouse embryonic lung development. LOXL3-deficient mice displayed reduced lung volumes and weights, diminished saccular spaces, and deformed and smaller thoracic cavities...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27628180/a-fatal-case-of-severe-neck-abscess-due-to-a-third-branchial-cleft-fistula-morphologic-and-immunohistochemical-analyses
#18
Fang Tong, Yue Liang, Muhammad Fasahat Khan, Lin Zhang, Wenhe Li, Mohammed Mahmoodurrahman, Yiwu Zhou
BACKGROUND: Branchial cleft anomalies constitute a frequently encountered and commonly non-lethal disease in otolaryngology, and result from aberrant embryonic development. The third branchial cleft fistula is one of the four known specific types of branchial cleft anomalies, and always presents as recurrent neck abscess and suppurative thyroiditis. Here, we report an unexpected death due to severe neck infection following a third branchial cleft fistula. CASE PRESENTATION: A 19-year-old man was sent to the hospital with a 1-week history of recurrent left-sided neck abscess, and was scheduled for incision and drainage of the abscess...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27610476/molecular-basis-for-the-mechanism-of-action-of-an-anti-tace-antibody
#19
Li Peng, Kimberly Cook, Linda Xu, Li Cheng, Melissa Damschroder, Changshou Gao, Herren Wu, William F Dall'Acqua
Inhibitors of tumor necrosis factor-α converting enzyme (TACE) have potential as therapeutics for various diseases. Many small molecule inhibitors, however, exhibit poor specificity profiles because they target the highly conserved catalytic cleft of TACE. We report for the first time the molecular interaction of a highly specific anti-TACE antagonistic antibody (MEDI3622). We characterized the binding of MEDI3622 using mutagenesis, as well as structural modeling and docking approaches. We show that MEDI3622 recognizes a unique surface loop of sIVa-sIVb β-hairpin on TACE M-domain, but does not interact with the conserved catalytic cleft or its nearby regions...
September 9, 2016: MAbs
https://www.readbyqxmd.com/read/27609391/-analysis-of-three-dimensional-stability-of-the-hypoplastic-maxilla-after-orthognathic-surgery-in-cleft-lip-and-palate-patients
#20
Jun-Zi Yingwang, Shun-Yao Shen, Biao Li, Hao Sun, Xu-Dong Wang
PURPOSE: To establish a three dimensional spacial measurement method to analyze the short-term stability of maxilla after orthognathic surgery in cleft lip and palate patients. METHODS: Twenty-five patients with maxillary hypoplasia secondary to cleft lip and palate seeking for orthognathic surgery were included in this study between January 2008 and September 2012. The spiral CT scan for the skull were taken 6 weeks preoperatively (T0), 4 days postoperatively (T1),3 months postoperatively (T2), and 6 months postoperatively (T3) and collected...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
keyword
keyword
50649
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"