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https://www.readbyqxmd.com/read/29779274/-outcome-and-influential-factors-of-speech-therapy-delivered-to-cleft-patients-with-post-operative-velopharyngeal-competence
#1
Chun-Li Guo, Heng Yin, Jing-Tao Li, Cheng-Hao Li, Yang Li, Bing Shi, Qian Zheng
OBJECTIVE: To analyze the training technique, intervention timing, and other related factors involved in the speech therapy delivered to cleft patients with velopharyngeal competence after surgery. METHODS: A retrospective study was conducted on 32 patients who received phonology-articulation speech therapies during 2012 to 2013 in Dept. of Cleft Lip and Palate, West China Hospital of Stomatology, Sichuan University. All patients achieved normal speech one year after therapy...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29771829/repairing-a-facial-cleft-by-polyether-ether-ketone-implant-combined-with-titanium-mesh
#2
Yuan Deng, Weiwei Tang, Zhengkang Li
The Tessier Number 4 cleft is one of the rarest, most complex craniofacial anomalies that presents difficulties in surgical treatment. In this article, we report a case of simultaneous facial depression, eye displacement, and medial canthus deformity. In this case, the maxillary bony defect was reconstructed using computer-assisted design computer-assisted manufacturing (CAD-CAM) polyether-ether-ketone (PEEK) material, and the orbital floor defect was repaired with AO prefabricated titanium mesh. Additionally, the medial canthus was modified with canthopexy and a single Z-plasty flap...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770817/the-dietary-compound-luteolin-inhibits-pancreatic-cancer-growth-by-targeting-bcl-2
#3
Zhimei Li, Yiyuan Zhang, Lixia Chen, Hua Li
Overexpression of the prosurvival protein BCL-2 contributes to malignant cell initiation, progression and resistance to treatment. Agents that function as its natural antagonists targeting BCL-2 must provide therapeutic benefit. In SW1990 pancreatic cancer cells, amplified BCL-2 was observed, which was believed to offer advantages for malignant cell survival and lead to poor patient outcome. Using structure-based virtual ligand screening, luteolin was found to be a natural small-molecule inhibitor of BCL-2, which exhibited dose-response proapoptosis activity in a BCL-2 dependent manner in vitro...
May 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29769040/novel-aggrecan-variant-p-gln2364pro-causes-severe-familial-nonsyndromic-adult-short-stature-and-poor-growth-hormone-response-in-chinese-children
#4
Dandan Xu, Chengjun Sun, Zeyi Zhou, Bingbing Wu, Lin Yang, Zhuo Chang, Miaoying Zhang, Li Xi, Ruoqian Cheng, Jinwen Ni, Feihong Luo
BACKGROUND: Mutations in the aggrecan (ACAN) gene can cause short stature (with heterogeneous clinical phenotypes), impaired bone maturation, and large variations in response to growth hormone (GH) treatment. For such cases, long-term longitudinal therapy data from China are still scarce. We report that a previously unknown ACAN gene variant reduces adult height and we analyze the GH response in children from an affected large Chinese family. METHODS: Two children initially diagnosed with idiopathic short stature (ISS) and a third mildly short child from a large Chinese family presented with poor GH response...
May 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29764021/-misdiagnosic-analysis-and-treatment-of-pyriform-sinus-fistula-in-children
#5
J Ma, C Ming, F Lou, M L Wang, K Lin, W J Zeng, Z C Li, X F Liu, T S Zhang
Objective: To discuss the misdiagnosis of pyriform sinus fistula and to better understand this kind of illness. Methods: The analysis was based on twenty-eight patients with congenital pyriform sinus fistula aged from 11 months to 14 years, with the median age of 5 years, and who were surgically treated from January 2013 to January 2017 in Kunming Children's Hospital.Twenty patients were misdiagnosed in other hospital.After the routine examination of neck ultrasound and enhanced CT, internal fistula was found by self-retaining laryngoscope, traced by methylene blue, and excised by high ligation...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29739092/satb2-associated-syndrome-a-case-report-of-a-de-novo-nonsense-mutation-in-satb2-from-china-and-review-of-literature
#6
Hong-Yan Lv, Rui-Jiang Zheng, Qiu-Li Wang, Peng-Shun Ren, Lin-Hong Jin, Xiu-Ling Gu, Lian-Xiang Li
BACKGROUND: To study the clinical and genetic features from a Chinese child with SATB2-associated syndrome (SAS) and review of literature. METHODS: The girl, 2 years 3 months old, is admitted to the Department of Pediatric Rehabilitation in our hospital. This patient has mental retardation, language development disorder, cleft palate II0, micrognathia, malocclusion, irritability and bilateral oblique palpebral fissure as a clinical manifestation and is treated for 3 months...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29704484/role-of-the-c-terminus-mobile-domain-of-cardiac-troponin-i-in-the-regulation-of-thin-filament-activation-in-skinned-papillary-muscle-strips
#7
Nazanin Bohlooli Ghashghaee, King-Lun Li, R John Solaro, Wen-Ji Dong
The C-terminus mobile domain of cTnI (cTnI-MD) is a highly conserved region which stabilizes the actin-cTnI interaction during the diastole. Upon Ca2+ -binding to cTnC, cTnI-MD participates in a regulatory switching that involves cTnI to switch from interacting with actin toward interacting with the Ca2+ -regulatory domain of cTnC. Despite many studies targeting the cTnI-MD, the role of this region in the length-dependent activation of cardiac contractility is yet to be determined. The present study investigated the functional consequences of losing the entire cTnI-MD in cTnI(1-167) truncation mutant, as it was exchanged for endogenous cTnI in skinned rat papillary muscle fibers...
April 25, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29688589/evaluating-the-effect-of-nicotinic-cholinergic-receptor-genes-on-the-risk-of-nonsyndromic-cleft-lip-with-or-without-cleft-palate
#8
Mengying Wang, Dongjing Liu, Holger Schwender, Hong Wang, Ping Wang, Zhibo Zhou, Jing Li, Tao Wu, Hongping Zhu, Terri H Beaty
OBJECTIVE: Multiple studies have suggested nonsyndromic cleft lip with or without cleft palate (NSCL/P) and lung cancer may have common genetic etiology. Previous studies have showed genetic variants in nicotinic cholinergic receptor genes (CHRNs) may influence risk of lung cancer. We aimed to explore the effect of CHRNs on risk of NSCL/P considering gene-gene (GxG) interaction for these genes. SUBJECTS AND METHODS: We selected 120 markers in 14 CHRNs to test for GxG interaction using 806 Chinese case-parent trios recruited from an international consortium established for a GWAS of oral clefts...
April 24, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29679588/growth-and-development-of-craniofacial-structures-in-patients-at-different-ages-with-unrepaired-submucous-cleft-palate
#9
Congcong Cao, Xue Xu, Qian Zheng, Bing Shi, Jingtao Li, Yan Wang
PURPOSE: Submucous cleft palate (SMCP) is a particular subtype of cleft palate deformity; research related to the craniofacial features of patients with SMCP is comparatively rare. The study objective was to perform a cephalometric comparison of the craniofacial features of patients with SMCP and non-cleft controls at different ages. MATERIALS AND METHODS: The sample in this cross-sectional study was composed of 2 groups: SMCP patients and non-cleft controls. The primary predictor variables were study group (cleft and non-cleft) and age...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29652906/mechanical-analyses-of-critical-surgical-maneuvers-in-the-correction-of-cleft-lip-nasal-deformity
#10
Hanyao Huang, Yeping Li, Xiangyou Luo, Xu Cheng, Bing Shi, Jingtao Li
The relapse of nasal deformity is a challenge for modern correction of cleft lip. A comprehensive understanding in the biomechanical perspective of both the formation and correction of the cleft lip nasal deformity would lead to improved stability of the corrective outcome. In this study, a finite element model of secondary cleft lip nasal deformity was constructed, on which two critical corrective maneuvers were mimicked in the form of force-loading. The intercrural suture was simulated by a force loaded at the intermediate crus of the alar cartilage directing anteriorly and medially, and the suture suspending the alar cartilage to the upper lateral cartilage was simulated by a force loaded at the lateral crus directing superiorly and medially...
2018: PloS One
https://www.readbyqxmd.com/read/29652536/computed-tomography-assisted-auricular-cartilage-graft-for-depression-of-the-alar-base-in-secondary-unilateral-cleft-lip-repair-a-preliminary-report
#11
Hong Chen, Chun-Ye Chen, Qing-Qing Fang, Min-Xia Zhang, Wan-Yi Zhao, Xiao-Feng Wang, Wei-Qiang Tan, Li-Yun Zhang
OBJECTIVES: To evaluate the feasibility, effectiveness, and safety of computed tomography-assisted auricular cartilage grafting for treating alar base depression secondary to unilateral cleft lip. DESIGN AND SETTING: For patients with obvious depression of the alar base, the difference in heights of the alar base and the piriform margin between the cleft side and the noncleft side were measured with computed tomography. If both were >3.0 mm, the cartilage was harvested postauricularly and subdivided into 2 to 4 pieces...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29649577/bioinformatics-characterization-of-a-cathepsin-b-transcript-from-the-giant-river-prawn-macrobrachium-rosenbergii-homology-modeling-and-expression-analysis-after-aeromonas-hydrophila-infection
#12
Saowalak Onming, Wilawan Thongda, Chao Li, Orathai Sawatdichaikul, Nichanun McMillan, Sirawut Klinbunga, Eric Peatman, Supawadee Poompuang
Cathepsin B is a lysosomal proteolytic enzyme that has been suggested to play a role in pathological processes of immune system. In this study, the full-length cDNA sequence of cathepsin B transcript in the giant river prawn Macrobrachium rosenbergii (MrCTSB) was obtained from 454 pyrosequencing of cDNAs from hepatopancreas and muscle. It was 1158 bp in length, containing an open reading frame (ORF) of 987 bp corresponding to 328 amino acids. The predicted molecular mass and pI of MrCTSB protein was 36...
April 9, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29617128/processive-degradation-of-crystalline-cellulose-by-a-multimodular-endoglucanase-via-a-wirewalking-mode
#13
Kun-Di Zhang, Wen Li, Yefei Wang, Yan-Lin Zheng, Fang-Cheng Tan, Xiao-Qing Ma, Lishan Yao, Edward A Bayer, Lushan Wang, Fuli Li
Processive hydrolysis of crystalline cellulose by cellulases is a critical step for lignocellulose deconstruction. The classic Trichoderma reesei exoglucanase TrCel7A, which has a closed active-site tunnel, starts each processive run by threading the tunnel with a cellulose chain. Loop regions are necessary for tunnel conformation, resulting in weak thermostability of fungal exoglucanases. However, endoglucanase CcCel9A, from the thermophilic bacterium Clostridium cellulosi, comprises a glycoside hydrolase (GH) family 9 module with an open cleft and five carbohydrate-binding modules (CBMs) and hydrolyzes crystalline cellulose processively...
April 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29609259/-progress-in-next-generation-sequencing-research-of-non-syndromic-oral-clefts
#14
M Y Wang, D J Liu, H Huang, W Y Li, R Zhou, H P Zhu, Z B Zhou, T Wu
Non-syndromic oral clefts (NSOC) are among the most common birth defects. The prevalence of NSOC is 1.13-1.30 per 1 000 live births in China, which is higher than those in other major ethnic groups. The etiology of NSOC is complex and heterogeneous, which involves both genetic and environmental risk factors. Although genome-wide association studies have identified a number of risk loci, these loci can only account for a small proportion of the heritability of NSOC. The next-generation sequencing research provides new ideas for further exploring the genetic risk factors of NSOC...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29608334/genome-wide-dna-methylation-analysis-during-palatal-fusion-reveals-the-potential-mechanism-of-enhancer-methylation-regulating-epithelial-mesenchyme-transformation
#15
Xuan Shu, Shenyou Shu, Hongqiu Cheng, Shijie Tang, Lujun Yang, Haihong Li, Mingjun Zhang, Zhensen Zhu, Dan Liu, Ke Li, Zejun Dong, Liuhanghang Cheng, Jialong Ding
Epithelial mesenchyme transformation (EMT) of the medial edge epithelium (MEE) is the crucial process during palatal fusion. This work is aimed to elucidate the enhancer regulatory mechanism by genome-wide DNA methylation analysis of EMT during palatal fusion. Over 800 million clean reads, 325 million enzyme reads, and 234 million mapping reads were generated. The mapping rate was 68.85-74.32%, which included differentially methylated 17299 CCGG sites and 2363 CCWGG sites (p < 0.05, log2 FC >1). Methylated sites in intron and intergenic regions were more compared to other regions of all DNA elements...
April 2, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29603291/improvement-in-early-detection-of-orofacial-clefts-using-the-axial-view-of-the-maxilla
#16
Ming M Zheng, Hui R Tang, Yan Zhang, Tong Ru, Jie Li, Bi Y Xu, Yan Gu, Yan Xu, Ya L Hu
OBJECTIVES: To evaluate the performance of the maxilla in the axial view in detection of orofacial clefts (OC) compared with the retronasal triangle(RNT) in the coronal view and palatine line in the sagittal view at the early stage of gestation. METHODS: A total of 2982 fetuses (including 315 twins) were enrolled for the first-trimester screening in this prospective study. The maxilla in the axial view, palatine line in the sagittal view and RNT in the coronal view were scanned by two-dimension ultrasound...
March 30, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29602346/dentoskeletal-effects-of-facemask-therapy-in-skeletal-class-iii-cleft-patients-with-or-without-bone-graft
#17
Yixin Zhang, Haichao Jia, Zhen Fu, Yiping Huang, Zhizun Wang, Runzhi Guo, Jiaan Shen, Weiran Li
INTRODUCTION: The association between maxillary protraction and bone graft in patients with cleft lip and palate remains unclear. The purpose of this study was to investigate whether a secondary alveolar bone graft influences dentoskeletal effects of facemask therapy in unilateral cleft lip and palate patients with a skeletal Class III relationship. METHODS: In this prospective nonrandomized clinical trial, 61 consecutive boys with unilateral cleft lip and palate and skeletal Class III malocclusion were divided into 3 groups: grafted facemask group (n = 21), ungrafted facemask group (n = 20), and untreated control group (n = 20)...
April 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29596046/ensemble-cryoem-elucidates-the-mechanism-of-insulin-capture-and-degradation-by-human-insulin-degrading-enzyme
#18
Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tang
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type 2 diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remained unsolved. We used cryoEM to understand both the apo- and insulin-bound dimeric IDE states, revealing that IDE displays a large opening between the homologous ~55 kDa N- and C-terminal halves to allow selective substrate capture based on size and charge complementarity...
March 29, 2018: ELife
https://www.readbyqxmd.com/read/29594989/-influence-of-dexamethasone-on-the-cell-polarity-and-par-complex-of-the-embryonic-epithelial-cells-in-the-palate
#19
Ma Li, Shi Bing, Zheng Qian
OBJECTIVE: This study aims to investigate whether dexamethasone (DEX) can down-regulate the PAR complex and disrupt the cell polarity in the palatal epithelium during palatal fusion. METHODS: Pregnant rats were randomly divided into control and DEX groups, which were injected intraperitoneally with 0.9% sodium chloride (0.1 mL) and DEX (6 mg·kg ⁻¹), respectively, every day from E10 to E12. The palatal epithelial morphology was observed using hematoxylin and eosin staining and scanning electron microscopy...
February 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29575419/forty-nine-cases-of-acute-lymphoblastic-leukaemia-lymphoma-in-pleural-and-pericardial-effusions-a-cytological-histological-correlation
#20
J Li, W Zhang, W Wang, Y Jiang, S Zhao, W Liu, G Li, N Liu, Q Li, X Su
INTRODUCTION: Acute lymphoblastic leukaemia/lymphoma (ALL/LBL) is an aggressive entity of precursor lymphoid neoplasm and may cause malignant serous effusion (SE). The current study aimed to analyse the characteristics of SE cytology of ALL/LBL including cytomorphology, immunophenotyping, clonality and evaluate the effectiveness of SE cytology as a diagnostic method for ALL/LBL. METHODS: SE specimens with final diagnosis of ALL/LBL from 2006 to 2016 were reviewed for clinical data, cytomorphological features and ancillary studies...
April 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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