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https://www.readbyqxmd.com/read/28550808/the-association-between-height-and-hypertension-in-indonesia
#1
Kitae Sohn
There is growing interest in the influence of early-life conditions on the development of disease. Among diseases in adulthood, hypertension is particularly important for the developing world because considerably more people there are and will be afflicted with the disease than in the developed world and hypertensives there are often unaware of their disease status. We employed height as a proxy for the influence of early-life conditions and estimated the relation between height and hypertension status in Indonesia...
May 8, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28550793/acute-gonadotropin-releasing-hormone-agonist-treatment-enhances-extinction-memory-in-male-rats
#2
L Y Maeng, M B Taha, K K Cover, S S Glynn, M Murillo, K Lebron-Milad, M R Milad
Leuprolide acetate (LEU), also known as Lupron, is commonly used to treat prostate cancer in men. As a gonadotropin-releasing hormone (GnRH) receptor agonist, it initially stimulates the release of gonadal hormones, testosterone (T) and estradiol. This surge eventually suppresses these hormones, preventing the further growth and spread of cancer cells. Individuals receiving this treatment often report anxiety and cognitive changes, but LEU's effects on the neural mechanisms that are involved in anxiety during the trajectory of treatment are not well known...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28550766/gender-differences-in-quality-of-life-and-functional-disability-for-depression-outpatients-with-or-without-residual-symptoms-after-acute-phase-treatment-in-china
#3
Na Zhao, Xiaohong Wang, Wenyuan Wu, Yongdong Hu, Yajuan Niu, Xueyi Wang, Chengge Gao, Ning Zhang, Yiru Fang, Jizhong Huang, Tiebang Liu, Fujun Jia, Xuequan Zhu, Jian Hu, Gang Wang
BACKGROUND: Depression is associated with substantial personal suffering and reduced quality of life and functioning. The aim of this study was to investigate gender differences on quality of life and functional impairment of outpatients with depression after acute phase treatment. METHODS: 1503 depression outpatients were recruited from eleven hospitals in China. Subjects were evaluated with sociodemographic characteristics, history and self-report instruments, related to severity of symptoms, function and quality of life...
May 17, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28550647/genetic-variation-in-the-adipoq-gene-adiponectin-concentrations-and-risk-of-colorectal-cancer-a-mendelian-randomization-analysis-using-data-from-three-large-cohort-studies
#4
Katharina Nimptsch, Mingyang Song, Krasimira Aleksandrova, Michail Katsoulis, Heinz Freisling, Mazda Jenab, Marc J Gunter, Konstantinos K Tsilidis, Elisabete Weiderpass, H Bas Bueno-De-Mesquita, Dawn Q Chong, Majken K Jensen, Chunsen Wu, Kim Overvad, Tilman Kühn, Myrto Barrdahl, Olle Melander, Karin Jirström, Petra H Peeters, Sabina Sieri, Salvatore Panico, Amanda J Cross, Elio Riboli, Bethany Van Guelpen, Robin Myte, José María Huerta, Miguel Rodriguez-Barranco, José Ramón Quirós, Miren Dorronsoro, Anne Tjønneland, Anja Olsen, Ruth Travis, Marie-Christine Boutron-Ruault, Franck Carbonnel, Gianluca Severi, Catalina Bonet, Domenico Palli, Jürgen Janke, Young-Ae Lee, Heiner Boeing, Edward L Giovannucci, Shuji Ogino, Charles S Fuchs, Eric Rimm, Kana Wu, Andrew T Chan, Tobias Pischon
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28550547/-when-is-determination-of-serum-testosterone-levels-in-men-indicated
#5
REVIEW
Frank-Michael Köhn, Hans-Christian Schuppe
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28550519/drug-abuse-associated-mortality-across-the-lifespan-a-population-based-longitudinal-cohort-and-co-relative-analysis
#6
Kenneth S Kendler, Henrik Ohlsson, Kristina Sundquist, Jan Sundquist
PURPOSE: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. METHOD: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Registers. Mortality was obtained from the Swedish Mortality registry...
May 26, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28550497/clinicopathological-features-of-intraductal-papillary-neoplasms-of-the-bile-duct-a-comparison-with-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-with-reference-to-subtypes
#7
Yuki Fukumura, Yasuni Nakanuma, Yuko Kakuda, Masaru Takase, Takashi Yao
Intraductal papillary epithelial neoplasms of the pancreatobiliary system (intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN)) seem to share many clinicopathological features; however, IPNB has not been fully characterized. In order to understand the clinicopathological/immunohistochemical features of IPNB better, we compared 52 cases of IPNB with 42 cases of IPMNs with mural nodules. The IPNB cases were divided into two groups according to their histological similarity and according to five key histological findings...
May 26, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28550461/a-systematic-review-of-the-literature-on-cystodistension-in-bladder-pain-syndrome
#8
Louise E Olson, James E Dyer, Ahsanul Haq, Jeremy Ockrim, Tamsin J Greenwell
INTRODUCTION AND HYPOTHESIS: There is significant variability in technique for cystodistension and an international discrepancy in the role in its treatment of bladder pain syndrome (BPS). The authors evaluate the evidence base for the use of cystodistension for BPS with particular reference to patient-related outcomes. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement, a prospective search and evaluation protocol was prepared and registered with the PROSPERO database (ID CRD42017053710)...
May 26, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28550415/high-expression-of-grp78-bip-as-a-novel-predictor-of-favorable-outcomes-in-patients-with-advanced-thymic-carcinoma
#9
Yosuke Miura, Kyoichi Kaira, Reiko Sakurai, Hisao Imai, Yoshio Tomizawa, Noriaki Sunaga, Koichi Minato, Takeshi Hisada, Tetsunari Oyama, Masanobu Yamada
BACKGROUND: Glucose-regulated protein (GRP) 78/immunoglobulin heavy chain binding protein (BiP) is a member of the endoplasmic reticulum chaperone family, and its role in various types of human malignancies has recently been investigated. However, the clinicopathological characteristics of GRP78/BiP in advanced thymic carcinoma (ATC) remain unknown. We aimed to examine the relationship between GRP78/BiP expression and the clinical outcomes of ATC patients. METHODS: Thirty-four patients with ATC receiving combination chemotherapy at three institutions between April 1998 and April 2014 were enrolled in this study...
May 26, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28550390/clinical-patterns-and-characteristics-of-ankylosing-spondylitis-in-china
#10
Qiaoxia Qian, Xia Xu, Hongjun He, Hengdong Ji, Hui Zhang, Yue Ding, Sheng-Ming Dai, Yaohong Zou, Qi Zhu, Chengde Yang, Shuang Ye, Lindi Jiang, Jian-Ping Tang, Qiang Tong, Dongyi He, Dongbao Zhao, Yuan Li, Yanyun Ma, Jingru Zhou, Ziyu Yuan, Juan Zhang, Li Jin, Xiaodong Zhou, John D Reveille, Hejian Zou, Jiucun Wang
The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset. The multicenter cross-sectional survey was conducted and 1251 patients were enrolled across China, representing a broad spectrum of Chinese AS patients. The mean age at onset and diagnosis were 29.2 (11.4) and 33.5 (12.6) years, respectively. The male/female ratio was 2.7:1. Acute anterior uveitis (AAU) was experienced in 10...
May 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28550386/human-sperm-toll-like-receptor-4-tlr4-mediates-acrosome-reaction-oxidative-stress-markers-and-sperm-parameters-in-response-to-bacterial-lipopolysaccharide-in-infertile-men
#11
Sana Sahnoun, Afifa Sellami, Nozha Chakroun, Malek Mseddi, Hammadi Attia, Tarek Rebai, Saloua Lassoued
PURPOSE: To study the role of Toll-like receptor 4 (TLR4) in human spermatozoa and to assess sperm parameters, oxidative stress markers, and acrosome reaction in response to the stimulation of TLR4 by its ligand, the lipopolysaccharide (LPS), as a major endotoxin of Gram-negative bacteria. METHODS: Our study was carried out in 73 sperm samples from patients undergoing semen analysis for couple infertility investigations. The studied patients were divided into three groups: normozoospermic fertile patients (n = 13), patients with abnormal and leukospermic semen (n = 13), and patients with abnormal and non-leukospermic semen (n = 47)...
May 26, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28550380/barriers-motivators-and-facilitators-to-engagement-in-hiv-care-among-hiv-infected-ghanaian-men-who-have-sex-with-men-msm
#12
Adedotun Ogunbajo, Trace Kershaw, Sameer Kushwaha, Francis Boakye, Nii-Dromo Wallace-Atiapah, LaRon E Nelson
In Ghana, men who have sex with men (MSM) bear a high burden of HIV. Identifying factors that influence engagement in HIV care among HIV-infected Ghanaian MSM is critical to devising novel interventions and strengthening existing programs aimed at improving outcomes across the HIV care continuum. Consequently, we conducted an exploratory qualitative research study with 30 HIV-infected Ghanaian MSM between May 2015 and July 2015. Common barriers were fear of being seen in HIV-related health facility, financial difficulties, and health system challenges...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550378/longitudinal-modeling-of-depressive-trajectories-among-hiv-infected-men-using-cocaine
#13
Shibani Mukerji, Roxanna Haghighat, Vikas Misra, David R Lorenz, Alex Holman, Anupriya Dutta, Dana Gabuzda
Cocaine use is prevalent among HIV-infected individuals. While cross-sectional studies suggest that cocaine users may be at increased risk for depression, long-term effects of cocaine on depressive symptoms remain unclear. This is a longitudinal study of 341 HIV-infected and uninfected men (135 cocaine users and 206 controls) ages 30-60 enrolled in the Multicenter AIDS Cohort Study during 1996-2009. The median baseline age was 41; 73% were African-American. In mixed-effects models over a median of 4.8 years of observation, cocaine use was associated with higher depressive symptoms independent of age, education level, and smoking (n = 288; p = 0...
May 26, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28550244/apoe-%C3%AE%C2%B54-modulation-of-training-outcomes-in-several-cognitive-domains-in-a-sample-of-cognitively-intact-older-adults
#14
Ramón López-Higes, Inmaculada C Rodríguez-Rojo, José M Prados, Pedro Montejo, David Del-Río, María Luisa Delgado-Losada, Mercedes Montenegro, David López-Sanz, Ana Barabash
BACKGROUND: Most research points to the ɛ4 allele of the apolipoprotein E (APOE) gene as the most recognizable genetic risk factor associated with Alzheimer's disease pathogenesis. It has been also suggested that the APOEɛ4 allele has a negative influence on cognitive functioning, which begins long before cognitive impairment becomes manifest. However, still, little is known about the APOEɛ4 interaction with cognitive intervention programs. OBJECTIVE: The main goal of this study was to explore whether there was a differential APOE genotype modulation effect after cognitive training in different domains, such as language comprehension, executive functions, and memory...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28550144/exacerbation-of-oxygen-glucose-deprivation-induced-blood-brain-barrier-disruption-potential-pathogenic-role-of-interleukin-9-in-ischemic-stroke
#15
Sha Tan, Yilong Shan, Yuge Wang, Yinyao Lin, Siyuan Liao, Zhezhi Deng, Li Zhou, Wei Cai, Qin Zeng, Lei Zhang, Bingjun Zhang, Xuejiao Men, Haiyan Li, Xueqiang Hu, Changyou Wu, Lisheng Peng, Zhengqi Lu
Interleukin (IL) -9 exerts a variety of functions in autoimmune diseases. However, its role in ischemic brain injury remains unknown. The present study explored the biological effects of IL-9 in ischemic stroke. We recruited 42 patients newly diagnosed with ischemic stroke and 22 age- and sex-matched healthy controls. The expression levels of IL-9 and percentages of IL-9-producing T cells, including CD3+CD4+IL-9+ and CD3+CD8+IL-9+ cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals...
May 26, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28550116/myeloid-derived-cells-in-prostate-cancer-progression-phenotype-and-prospective-therapies
#16
REVIEW
Zoila Lopez-Bujanda, Charles G Drake
Prostate cancer is the second most common cause of cancer mortality in men in the United States. As is the case for other tumor types, accumulating evidence suggests an important role for myeloid-derived cells in the promotion and progression of prostate cancer. Here, we briefly describe myeloid-derived cells that interact with tumor cells and what is known about their immune suppressive function. We next discuss new evidence for tumor cell-mediated myeloid infiltration via the PI3K/PTEN/AKT signaling pathway and an alternative mechanism for immune evasion that may be regulated by an endoplasmic reticulum stress response...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28550081/randomized-controlled-trial-for-the-effect-of-vitamin-d-supplementation-on-vascular-stiffness-in-ckd
#17
Adeera Levin, Mila Tang, Taylor Perry, Nadia Zalunardo, Monica Beaulieu, Joshua A Dubland, Kelly Zerr, Ognjenka Djurdjev
BACKGROUND AND OBJECTIVES: Vitamin D is implicated in vascular health in CKD. This study compared placebo, calcifediol, and calcitriol treatment with changes in vascular stiffness, BP, proteinuria, mineral metabolism parameters, C-reactive protein, and fibroblast growth factor 23 in patients with stable CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a double-blind, randomized controlled trial in outpatient CKD clinics in Vancouver, Canada, from February of 2011 to August of 2014, enrolling 119 patients with an eGFR of 15-45 ml/min per 1...
May 26, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28550078/race-and-gender-differences-in-undergraduate-research-mentoring-structures-and-research-outcomes
#18
Melissa L Aikens, Melissa M Robertson, Sona Sadselia, Keiana Watkins, Mara Evans, Christopher R Runyon, Lillian T Eby, Erin L Dolan
Participating in undergraduate research with mentorship from faculty may be particularly important for ensuring the persistence of women and minority students in science. Yet many life science undergraduates at research universities are mentored by graduate or postdoctoral researchers (i.e., postgraduates). We surveyed a national sample of undergraduate life science researchers about the mentoring structure of their research experiences and the outcomes they realized from participating in research. We observed two common mentoring structures: an open triad with undergraduate-postgraduate and postgraduate-faculty ties but no undergraduate-faculty tie, and a closed triad with ties among all three members...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28549839/vitamin-b12-deficiency-might-be-related-to-sarcopenia-in-older-adults
#19
Esra Ates Bulut, Pinar Soysal, Ali Ekrem Aydin, Ozge Dokuzlar, Suleyman Emre Kocyigit, Ahmet Turan Isik
Sarcopenia and dynapenia are related to repeated falls, mobility restriction, depression, frailty, increased mortality and morbidity. The aim of this study is to evaluate the relationship between vitamin B12 deficiency and sarcopenia in older adults. 403 patients, who attended to outpatient clinic and underwent comprehensive geriatric assessment, were included study. All cases' skeletal muscle mass (SMM), walking speed and hand grip strength were recorded by bioimpedance, 4meter walking test and hand dynamometer respectively...
May 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28549831/adenocarcinoma-of-the-appendix-with-extra-appendicular-spread-clinico-surgical-and-histologic-analysis-of-27-cases
#20
Francisco J Morera Ocón, Bruno Camps Vilata, Elena Muñoz Forner, Clara Navarro Campoy, Javier Gallego Plazas, Samuel Navarro Fos
BACKGROUND AND OBJECTIVES: Appendiceal neoplasms with extra-appendiceal spread may show different clinical patterns with pseudomyxoma peritonei (PMP) being one of them. We analyse the results in a series of patients treated in our centre. MATERIAL AND METHODS: Retrospective study of patients operated on for appendiceal peritoneal carcinomatosis from January 2012 to May 2015. RESULTS: Twenty-seven consecutive patients were included. Median age 63 years (26-73); 14 were men...
May 23, 2017: Medicina Clínica
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