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https://www.readbyqxmd.com/read/28938735/the-age-of-fathers-in-the-usa-is-rising-an-analysis-of-168-867-480-births-from-1972-to-2015
#1
Yash S Khandwala, Chiyuan A Zhang, Ying Lu, Michael L Eisenberg
STUDY QUESTION: How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER: The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY: While the rise in mean maternal age and its implications for fertility, birth outcomes and public health have been well documented, little is known about paternal characteristics of births within the USA...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938731/the-importance-of-genetic-parenthood-for-infertile-men-and-women
#2
S Hendriks, K Peeraer, H Bos, S Repping, E A F Dancet
STUDY QUESTION: Do men and women beginning to attend a fertility clinic prefer genetic over non-genetic parenthood? SUMMARY ANSWER: Nearly, all infertile men and women prefer genetic parenthood. WHAT IS KNOWN ALREADY: Clinicians assume that all infertile couples prefer genetic parenthood over non-genetic parenthood and, therefore, consider treatments with donor gametes an option of last resort. Previous studies of the desire for parenthood identified 30 motivations for genetic parenthood, and 51 motivations for which having a genetically related child is not strictly necessary but might be deemed required...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938672/comparing-the-clinical-efficacy-of-abiraterone-acetate-enzalutamide-and-orteronel-in-patients-with-metastatic-castration-resistant-prostate-cancer-by-performing-a-network-meta-analysis-of-eight-randomized-controlled-trials
#3
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Ja Hyeon Ku, Hyeon Hoe Kim
Various novel androgen receptor (AR) targeting drugs have been developed recently and have shown beneficial effects on survival in patients with metastatic castration-resistant prostate cancer (mCRPC). However, no consensus has been reached regarding which of these agents provides the most favorable oncological outcomes. Here, we aimed to compare the efficacy of novel AR-targeted agents by performing a network meta-analysis of randomized controlled trials (RCTs). We included eight RCTs for men with mCRPC treated with one of the AR targeting agents: abiraterone acetate, enzalutamide, or orteronel...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938662/meta-analysis-of-the-association-between-the-inflammatory-potential-of-diet-and-colorectal-cancer-risk
#4
Yu Fan, Xin Jin, Changfeng Man, Zhenjun Gao, Xiaoyan Wang
OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case-control studies investigating the association of the DII score with CRC risk were selected...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938645/sex-specific-association-of-sh2b3-and-smarca4-polymorphisms-with-coronary-artery-disease-susceptibility
#5
Yuqiang Ji, Yanbin Song, Qingwen Wang, Pengcheng Xu, Zhao Zhao, Xia Li, Nan Wang, Tianbo Jin, Chao Chen
To determine whether sex differences affect the association between genetic polymorphisms and coronary artery disease (CAD) in the Chinese Han population, we conducted a study comparing the frequency of SH2B3 and SMARCA4 variants in 456 CAD patients (291 men, 165 women) and 685 age-matched controls (385 men, 300 women). Ten single nucleotide polymorphisms (SNPs) in SH2B3 and SMARCA4 were genotyped using MassARRAY technology. Allelic and genotypic models and haplotype frequencies were compared between groups...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938548/promoter-dna-methylation-analysis-reveals-a-combined-diagnosis-of-cpg-based-biomarker-for-prostate-cancer
#6
Yuanyuan Tang, Shusuan Jiang, Yinmin Gu, Weidong Li, Zengnan Mo, Yuanjie Huang, Tianyu Li, Yanling Hu
BACKGROUND: Prostate cancer (PCa) is the most common tumor in elderly men. However, the specificity and sensitivity of serum prostate-specific antigen levels in PCa diagnosis are controversial. This study aims to reveal a novel diagnosis biomarker in PCa. MATERIALS AND METHODS: The differential methylated CpG sites between 423 primary PCa and 39 adjacent samples from The Cancer Genome Atlas (TCGA) on Illumina HumanMethylation 450 platform were analyzed. The diagnostic methylation markers were mined using the Prediction Analysis of Microarrays package in Bioconductor...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938500/acceptability-of-two-colorectal-cancer-screening-tests-pain-as-a-key-determinant-in-sigmoidoscopy
#7
Benedicte Kirkøen, Paula Berstad, Edoardo Botteri, Eirin Dalén, Jens Aksel Nilsen, Geir Hoff, Thomas de Lange, Tomm Bernklev
Background Participants' experience with a screening test can influence adherence, and therefore the efficacy of screening programs. We compared screening with unsedated flexible sigmoidoscopy and fecal immunochemical testing (FIT) for participants' satisfaction with the decision and for willingness to repeat colorectal cancer screening. Methods In a prospective, randomized trial 3257 individuals (50 - 74 years) were invited to either flexible sigmoidoscopy or FIT (1:1), of whom 1650 took up the offer (52...
September 22, 2017: Endoscopy
https://www.readbyqxmd.com/read/28938493/acute-and-chronic-impact-of-bariatric-surgery-on-plasma-ldl-cholesterol-and-pcsk9-levels-in-patients-with-severe-obesity
#8
Marjorie Boyer, Marie-Eve Piché, Audrey Auclair, Thomas Grenier-Larouche, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Simon Biron, Stéfane Lebel, Odette Lescelleur, François Julien, Julie Martin, André Tchernof, André C Carpentier, Paul Poirier, Benoit J Arsenault
Context: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of low-density lipoprotein cholesterol (LDL-C) concentrations. In patients with severe obesity, biliopancreatic diversion with duodenal switch (BPD-DS) surgery induces substantial weight loss and favourably influence lipoprotein metabolism. The impact of BPD-DS surgery on PCSK9 levels is unknown. Objectives: To determine the acute and chronic impact of BPD-DS surgery on PCSK9 levels and whether the acute impact of BPD-DS could be explained by BPD-DS surgery-associated caloric restriction (CR)...
August 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938457/the-association-of-estrogen-receptor-%C3%AE-gene-variation-with-salt-sensitive-blood-pressure
#9
Worapaka Manosroi, Jia Wei Tan, Chevon M Rariy, Bei Sun, Mark O Goodarzi, Aditi R Saxena, Jonathan S Williams, Luminita H Pojoga, Jessica Lasky-Su, Jinrui Cui, Xiuqing Guo, Kent D Taylor, Yii-Der I Chen, Anny H Xiang, Willa A Hsueh, Leslie J Raffel, Thomas A Buchanan, Jerome I Rotter, Gordon H Williams, Ellen W Seely
Context: Hypertension in young women is uncommon compared to young men and older women. Estrogen appears to protect most women against hypertension with incidence increasing after menopause. Since some premenopausal women develop hypertension, estrogen may play a different role in these women. Genetic variations in the estrogen receptor (ER) are associated with cardiovascular disease. ER-β, encoded by ESR2, is the ER predominantly expressed in vascular smooth muscle. Objective: To determine an association of single nucleotide polymorphisms (SNPs) in ESR2 with salt-sensitivity of blood pressure (SSBP) and estrogen status in women...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938446/vitamin-d-and-testosterone-in-healthy-men-a-randomized-controlled-trial
#10
Elisabeth Lerchbaum, Stefan Pilz, Christian Trummer, Verena Schwetz, Oliver Pachernegg, Annemieke C Heijboer, Barbara Obermayer-Pietsch
Context: Available evidence shows an association of vitamin D with androgen levels in men. However, results from preliminary randomized controlled trials (RCTs) are conflicting. Objective: To evaluate whether vitamin D supplementation increases total testosterone (TT) levels in healthy men. Design: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between December 2012 and January 2017...
August 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938410/gender-difference-in-the-clinical-presentation-of-primary-hyperparathyroidism-influence-of-menopausal-status
#11
Elena Castellano, Roberto Attanasio, Alberto Boriano, Micaela Pellegrino, Francesca Garino, Laura Gianotti, Giorgio Borretta
Background: Female to male ratio in primary hyperparathyroidism (PHPT) is 3:1, but data on gender impact on the clinical presentation are limited. Methods: We evaluated retrospectively gender difference in biochemistry and clinical presentation at diagnosis in a monocentric series of 417 patients with PHPT: 93 men (58.6 ±14.5 years), and 324 women (61.7 ± 12.8 years), of whom 54 were pre-menopausal (pre-F) and 270 post-menopausal (post-F). Results: Men were significantly younger (p = 0...
September 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938407/fibroblast-growth-factor-21-metabolic-role-in-mice-and-men
#12
Harald Staiger, Michaela Keuper, Lucia Berti, Martin Hrabe de Angelis, Hans-Ulrich Häring
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very robust data documenting this factor's favorable effects on glucose and lipid metabolism in mice. For more than ten years now, intense in vivo and ex vivo experimentation addressed the physiological functions of FGF21 in humans as well as its pathophysiological role and pharmacological effects in human metabolic disease. This work produced a comprehensive collection of data revealing overlaps in FGF21 expression and function but also significant differences between mice and men that have to be considered before translation from bench to bedside can be successful...
July 28, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28938247/challenges-with-percent-predicted-maximum-vo2-in-patients-with-heart-failure
#13
Clinton A Brawner, Jonathan K Ehrman, Ali Shafiq, Matthew A Saval, Stuart D Russell, David E Lanfear, Steven J Keteyian
PURPOSE: To describe the influence of different equations to predict maximum oxygen uptake (MVO2) on the percent predicted MVO2 (ppMVO2) and the resultant categorization of patients with heart failure with reduced ejection fraction (HFrEF) into high or low risk. METHODS: In this retrospective cohort study, ppMVO2 was calculated using six different equations to predict MVO2 among 1,168 patients with HFrEF (33% women). Repeated measures analysis of variance was used to compare within-subject differences in mean ppMVO2 between the prediction equations...
September 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28938226/does-body-talk-improve-body-satisfaction-among-same-sex-couples
#14
Charlotte H Markey, Meghan M Gillen, Kristin J August, Patrick M Markey, Christopher S Nave
Research suggests the important role of romantic partners in shaping how individuals feel about their bodies (e.g., Markey & Markey, 2013, 2014), but the processes that result in changes in body satisfaction within relationships have rarely been examined. To investigate how partners may potentially affect body image, 72 lesbian couples and 72 gay male couples (total N=288) completed body image assessments on their own and with the help of their partners. Multilevel modeling revealed that both men and women reported an improvement in body satisfaction after talking with their partners while completing the body image assessment together...
September 19, 2017: Body Image
https://www.readbyqxmd.com/read/28938219/age-dependent-effects-of-acute-methylphenidate-on-amygdala-reactivity-in-stimulant-treatment-naive-patients-with-attention-deficit-hyperactivity-disorder
#15
Marco A Bottelier, Anouk Schrantee, Bart Ferguson, Hyke G H Tamminga, Cheima Bouziane, J J Sandra Kooij, Michiel B de Ruiter, Liesbeth Reneman
In the present study, we investigate whether methylphenidate (MPH) affects emotional processing and whether this effect is modulated by age. We measured amygdala reactivity with functional Magnetic Resonance Imaging (fMRI) during processing of angry and fearful facial expressions in male stimulant treatment-naive patients with ADHD (N = 35 boys; N = 46 men) and 23 healthy control subjects (N = 11 boys; N = 12 men). In ADHD patients, we also measured amygdala reactivity 90min after an acute oral challenge with MPH (0...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938183/age-trends-in-rates-of-substance-use-disorders-across-ages-18-90-differences-by-gender-and-race-ethnicity
#16
Sara A Vasilenko, Rebecca J Evans-Polce, Stephanie T Lanza
BACKGROUND: Although research has documented age differences in substance use, less is known about how prevalence of substance use disorders (SUDs) vary across age and differ by gender and race/ethnicity. METHODS: Time-varying effect models (TVEMs) were estimated on data from the National Epidemiologic Survey of Alcohol and Related Conditions-III (NESARC III; N=36,309), a nationally representative survey of the adult population. The sample was 44% male; 53% White, 21% Black, 19% Hispanic/Latino, 6% other race/ethnicity...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28938103/let-s-talk-about-sex-a-qualitative-study-exploring-the-experiences-of-hiv-nurses-when-discussing-sexual-risk-behaviours-with-hiv-positive-men-who-have-sex-with-men
#17
S de Munnik, C den Daas, H S M Ammerlaan, G Kok, M S Raethke, S C J M Vervoort
BACKGROUND: Despite prevention efforts, the incidence of sexually transmitted infection among HIV-positive men who have sex with men remains high, which is indicative of unchanged sexual risk behaviour. Discussing sexual risk behaviour has been shown to help prevent sexually transmitted infections among HIV-positive men who have sex with men. OBJECTIVES: The aim of this study was to identify factors that influence whether - and how - specialised HIV nurses discuss sexual risk behaviour with HIV-positive men who have sex with men...
September 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28937936/is-high-t-1-slope-a-significant-risk-factor-for-developing-interlaminar-bony-fusion-after-cervical-laminoplasty-a-retrospective-cohort-study
#18
Takeshi Oichi, Yasushi Oshima, Hiroyuki Oka, Yuki Taniguchi, Hirotaka Chikuda, Yoshitaka Matsubayashi, Katsushi Takeshita, Sakae Tanaka
OBJECTIVE Several investigators have reported the occurrence of interlaminar bony fusion after cervical laminoplasty, which is reportedly associated with reduced postoperative cervical range of motion (ROM). However, to the authors' knowledge, no previous study has investigated the characteristics of patients who were likely to develop interlaminar bony fusion after cervical laminoplasty. Therefore, the objective of this study was to investigate the risk factors for interlaminar bony fusion in patients with cervical spondylotic myelopathy (CSM) following cervical laminoplasty and to investigate the effect of interlaminar bony fusion on surgical outcomes...
September 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28937934/an-evaluation-of-new-york-city-s-2015-birth-certificate-gender-marker-regulation
#19
Erica J Lee, Danielle Gurr, Gretchen Van Wye
PURPOSE: In 1971, the New York City (NYC) Department of Health and Mental Hygiene amended Section 207.05 of the NYC Health Code to allow individuals who had undergone "convertive surgery" (interpreted by the code to mean genital surgery) to amend the gender on their birth certificates. This surgery requirement was removed in 2015. In a survey evaluating the regulation change, we sought to characterize the transgender population newly eligible to obtain a gender-congruent NYC birth certificate by comparing respondents with and without genital surgery...
September 22, 2017: LGBT Health
https://www.readbyqxmd.com/read/28937861/increased-suicides-during-new-year-but-not-during-christmas-in-sweden-analysis-of-cause-of-death-data-2006-2015
#20
Gergö Hadlaczky, Sebastian Hökby
BACKGROUND: Previous studies have investigated the impact of the Christmas and New Year holiday on suicide rates. However, no such data has yet been published on Swedish suicides. AIMS: To examine the occurrence of suicides on these dates in Sweden between 2006 and 2015. METHODS: The suicide count for each date between December 15th and January 15th was obtained from the Swedish cause of death registry. The observations were transformed to Z-scores to enable calculation of p-values...
September 22, 2017: Nordic Journal of Psychiatry
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