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https://www.readbyqxmd.com/read/29242509/shp2-associates-with-nuclear-localization-of-stat3-significance-in-progression-and-prognosis-of-colorectal-cancer
#1
Yan Huang, Jie Wang, Fuao Cao, Hailong Jiang, An Li, Jianzhong Li, Lei Qiu, Hao Shen, Wenjun Chang, Chuanxiang Zhou, Yamin Pan, Yiming Lu
Tyrosine phosphatase SHP2, encoded by PTPN11, has been implicated in many physiologic and pathologic processes in neoplastic progression. However, controversies are emerging from many studies, indicating SHP2 has a dual role in different types of tumors. We aimed to explore the role of SHP2 in progression and prognosis of colorectal cancer (CRC). SHP2 inhibited CRC cell proliferation and migration, and the phosphorylation of STAT3 was negatively regulated by SHP2 in CRC. SHP2 and nuclear STAT3 were examined in 270 CRC tissues...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241394/neoadjuvant-therapy-offers-longer-survival-than-upfront-surgery-for-poorly-differentiated-and-higher-stage-pancreatic-cancer
#2
Anna Nurmi, Harri Mustonen, Helka Parviainen, Katriina Peltola, Caj Haglund, Hanna Seppänen
BACKGROUND: Neoadjuvant therapy for pancreatic cancer remains controversial. Our aim was to assess differences in survival, disease recurrence and histopathological tumor characteristics between patients treated with neoadjuvant therapy followed by subsequent surgery and patients undergoing upfront surgery. MATERIAL AND METHODS: Out of 399 consecutive pancreatic ductal adenocarcinoma (PDAC) patients operated at Helsinki University Hospital in 2000-2015, 75 borderline resectable patients were treated with neoadjuvant therapy...
December 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29241308/infusion-of-porcine-derived-amniotic-fluid-stem-cells-for-treatment-of-experimental-colitis-in-mice
#3
Kun-Yi Lin, Shao-Yu Peng, Chih-Jen Chou, Herng-Sheng Lee, Leou-Chyr Lin, Ru-Yu Pan, Shinn-Chih Wu
Recently, stem cells have offered an alternative treatment for inflammatory bowel disease or colitis to overcome the poor outcomes associated with current therapies. Amniotic fluid-derived stem cells have the potential for the regeneration of impaired organs and the recovery of normal physiologic functions of damaged tissues without ethical concerns or risk of tumor formation. In this work, we aimed to examine the therapeutic effects of infusion of porcine amniotic fluid-derived stem cells (pAFSCs) in dextran sulfate sodium (DSS)-induced colitis in mice...
December 15, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29236491/short-chain-fatty-acids-suppress-inflammatory-reactions-in-caco-2-cells-and-mouse-colons
#4
Tran Van Hung, Takuya Suzuki
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, play an important role in the maintenance of intestinal homeostasis. In the present study, anti-inflammatory effects of SCFAs were examined in human intestinal Caco-2 cells and mouse colonic cultures. Stimulation of Caco-2 cells with tumor necrosis factor (TNF)-α induced interleukin (IL)-8 (TNF-α, 17.1 ± 7.2 vs Control, 1.00 ± 0.26, P<0.01) and IL-6 expression (TNF-α, 21.7 ± 10.0 vs Control, 1.00 ± 0.28, P<0.01) through the activation of nuclear factor κB p65, spleen tyrosine kinase, and mitogen-activated protein kinase pathways...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29235493/small-molecules-related-to-adrenomedullin-reduce-tumor-burden-in-a-mouse-model-of-colitis-associated-colon-cancer
#5
Laura Ochoa-Callejero, Josune García-Sanmartín, Sonia Martínez-Herrero, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Alfredo Martínez
To investigate the contribution of adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), to the progression and potential treatment of colon cancer we studied the effects of four small molecules (SM) related to AM and PAMP on a mouse model of colon cancer. For each SM, four experimental groups of male mice were used: (i) Control group; (ii) SM group; (iii) DSS group (injected with azoxymethane [AOM] and drank dextran sulfate sodium [DSS]); and (iv) DSS + SM group (treated with AOM, DSS, and the SM)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235006/intrinsic-contact-between-t-and-n-classifications-in-resected-well-moderately-differentiated-locoregional-pancreatic-neuroendocrine-neoplasms
#6
Jin-Zhi Xu, Wen-Quan Wang, Shi-Rong Zhang, Hua-Xiang Xu, Chun-Tao Wu, Zi-Hao Qi, He-Li Gao, Quan-Xing Ni, Liang Liu, Xian-Jun Yu
BACKGROUND: The role of N classification is controversial in several prognostication systems proposed for pancreatic neuroendocrine neoplasms (pNENs). The widely accepted modified European Neuroendocrine Tumor Society (mENETS) system suggests this contradiction may be related to T classification. METHODS: Data were collected retrospectively from 981 patients in the Surveillance, Epidemiology, and End Results (SEER) database (1973-2012; cohort 1) and 140 patients from the Pancreatic Cancer Institute of Fudan University (2006-2016; cohort 2)...
December 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29234405/qingchang-wenzhong-decoction-attenuates-dss-induced-colitis-in-rats-by-reducing-inflammation-and-improving-intestinal-barrier-function-via-upregulating-the-msp-ron-signalling-pathway
#7
Tangyou Mao, Junxiang Li, Lijuan Liu, Weihan Zhao, Yuyue Liu, Kangli Gao, Yi Guo, Tianhong Xie, Ningfei Li, Rui Shi
Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease for which an effective treatment is lacking. Our previous study found that Qingchang Wenzhong Decoction (QCWZD) can significantly improve the clinical symptoms of UC and ameliorate dextran sulphate sodium- (DSS-) induced ulcerative colitis in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response. The purpose of the present study was to further explore the mechanism of QCWZD for UC in rats models, which were established by 7-day administration of 4...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233556/contribution-of-atoh1-cells-to-the-homeostasis-repair-and-tumorigenesis-of-the-colonic-epithelium
#8
Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto
ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs). However, the comprehensive contribution of ATOH1+ secretory lineage IECs to the homeostasis, repair, and tumorigenesis of the intestinal epithelium remains uncertain. Through our ATOH1+ cell-lineage tracing, we show here that a definite number of ATOH1+ IECs retain stem cell properties and can form ATOH1+IEC-derived clonal ribbons (ATOH1+ICRs) under completely homeostatic conditions. Interestingly, colonic ATOH1+ IECs appeared to exhibit their stem cell function more frequently compared with those of the small intestine...
December 1, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29228910/the-prognosis-of-invasive-micropapillary-carcinoma-compared-with-invasive-ductal-carcinoma-in-the-breast-a-meta-analysis
#9
Yun Wu, Ning Zhang, Qifeng Yang
BACKGROUND: Invasive micropapillary carcinoma (IMPC) of the breast is a rare variant of invasive ductal carcinoma (IDC). The prognosis of IMPC compared with that of IDC remains controversial; we conducted a meta-analysis to evaluate the prognostic difference between IMPC and IDC. METHODS: We searched the PubMed, Cochrane Library, and EMBASE databases for relevant studies comparing overall survival (OS), disease-specific survival (DSS), relapse-free survival (RFS), local-regional recurrence-free survival (LRRFS) or distant metastasis-free survival (DMFS) rates between IMPC and IDC...
December 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29228739/regulatory-role-of-nkg2d-nk-cells-in-intestinal-lamina-propria-by-secreting-double-edged-th1-cytokines-in-ulcerative-colitis
#10
Fan Wang, Pai-Lan Peng, Xue Lin, Ying Chang, Jing Liu, Rui Zhou, Jia-Yan Nie, Wei-Guo Dong, Qiu Zhao, Jin Li
The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis. We found that DSS-induced colitis in mice was characterized by a Th2-mediated process...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228622/comparison-between-liver-resection-and-liver-transplantation-on-outcomes-in-patients-with-solitary-hepatocellular-carcinoma-meeting-unos-criteria-a-population-based-study-of-the-seer-database
#11
Anli Yang, Weiqiang Ju, Xiaopeng Yuan, Ming Han, Xiaoping Wang, Zhiyong Guo, Xiaoli Wei, Dongping Wang, Xiaofeng Zhu, Linwei Wu, Xiaoshun He
Liver resection (LR) and liver transplantation (LT) are potential curative treatment methods for early hepatocellular carcinoma (HCC). However, it is controversial which treatment is more beneficial to patients with solitary HCC meeting the United Network for Organ Sharing (UNOS) criteria (single lesion, diameter≤50mm, no vascular invasion, no extrahepatic metastasis). We retrieved patients with solitary HCC meeting UNOS criteria diagnosed between 2004-2013 from the Surveillance Epidemiology and End Results (SEER) database...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228570/keratin-8-reduces-colonic-permeability-and-maintains-gut-microbiota-homeostasis-protecting-against-colitis-and-colitis-associated-tumorigenesis
#12
Chao Liu, En-Dong Liu, Yun-Xiao Meng, Xiao-Ming Dong, Ya-Lan Bi, Huan-Wen Wu, Yan-Chao Jin, Ke Zhao, Jian-Jie Li, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Xiao-Ming Yang, Chang-Yan Li
Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the colon during DSS-induced colitis and AOM/DSS-induced colitis-associated colorectal cancer (CAC) development. In human patients with colon cancer, CK8 is downregulated. Using CK8 heterozygous knockout mice (CK8+/-), we found that CK8+/- mice are highly susceptible to DSS-induced colitis and more prone to AOM/DSS-induced CAC than wild type (WT) mice...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228136/cd177-neutrophils-suppress-epithelial-cell-tumourigenesis-in-colitis-associated-cancer-and-predict-good-prognosis-in-colorectal-cancer
#13
Guangxi Zhou, Kangsheng Peng, Yang Song, Wenjing Yang, Weigang Shu, Tianming Yu, Lin Yu, Moubin Lin, Qing Wei, Chunqiu Chen, Lu Yin, Yingzi Cong, Zhanju Liu
Neutrophils are found to be infiltrated in tumour tissues of patients with colitis-associated cancer (CAC) and colorectal cancer (CRC), and CD177 is mainly expressed in neutrophils. In our study, expression of CD177 in tumour tissues from patients with CAC or CRC was analysed by qRT-PCR, flow cytometry, and immunohistochemistry. We recruited 378 patients with CRC, determined CD177 expression in tumours, and examined its correlation with clinicopathological features. Moreover, CAC model was induced in wild type (WT) and CD177-/- mice by azoxymethane (AOM)/dextran sodium sulfate (DSS)...
December 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29225757/dengue-fever-in-a-south-asian-metropolis-a-report-on-219-cases
#14
Shiv Sekhar Chatterjee, Ankush Sharma, Shilpee Choudhury, Sushil Kumar Chumber, Ras Bage, Nittin Parkhe, Uma Khanduri
Background and Objectives: Yearly epidemics of Dengue fever occur post-monsoon in India's capital, Delhi. A prospective observational study was conducted during the outbreak months to understand the epidemiology and outcome of this infection and its economic impact. Materials and Methods: Febrile hospitalized (n=219) patients with dengue fever diagnosed by a combination of MAC-ELISA, GAC-ELISA and NS1Antigen-ELISA were enrolled. Epidemiologic (including economic) parameters, clinical, radiological and laboratory manifestations were noted and patients followed up over the period of hospital stay...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29224815/definitive-chemo-radiotherapy-is-a-curative-alternative-for-standard-of-care-in-advanced-stage-squamous-cell-carcinoma-of-the-oral-cavity
#15
Joris B W Elbers, Abrahim Al-Mamgani, Danique Paping, Michiel W M van den Brekel, Katarzyna Jóźwiak, J P de Boer, Baris Karakullukcu, Marcel Verheij, Charlotte L Zuur
OBJECTIVE: To compare outcome after definitive (chemo)radiotherapy (CRT group) with standard of care (surgery group) for advanced stage oral cavity carcinoma (OCC). Although definitive (chemo)radiotherapy is assumed to be inferior to surgery with regard to disease control, data on outcome of this approach are scarce. METHODS: Retrospective analysis by chart review (2000-2013). Endpoints were locoregional control (LRC), disease-free survival (DFS), disease specific survival (DSS) and overall survival (OS)...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224814/transoral-robotic-surgery-based-therapy-in-patients-with-stage-iii-iv-oropharyngeal-squamous-cell-carcinoma
#16
Young Min Park, Hye Ryun Kim, Byoung Chul Cho, Ki Chang Keum, Nam Hoon Cho, Se-Heon Kim
OBJECTIVE: TORS-based therapy including chemotherapy or RTx was administered to patients with stage III-IV OPSCC. We analyzed the oncological and functional outcomes of stage III-IV OPSCC patients who underwent TORS-based therapy. MATERIALS AND METHODS: Between May 2008 and May 2016, 80 patients participated in this clinical trial. RESULTS: A negative margin was identified in 66 patients (82.5%) and a positive margin in 14 (17.5%). TNM stages were III in 13 patients (16...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224190/metabolic-surgery-for-the-treatment-of-type-2-diabetes-in-obese-individuals
#17
REVIEW
David E Cummings, Francesco Rubino
Several bariatric operations originally designed to promote weight loss have been found to powerfully treat type 2 diabetes, causing remission in most cases, through diverse mechanisms additional to the secondary consequences of weight loss. These observations have prompted consideration of such operations as 'metabolic surgery', used expressly to treat diabetes, including among patients who are only mildly obese or merely overweight. Large, long-term observational studies consistently demonstrate that bariatric/metabolic surgery is associated with reductions in all cardiovascular risk factors, actual cardiovascular events, microvascular diabetes complications, cancer and death...
December 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/29222175/chitin-protects-gut-epithelial-barrier-in-a-protochordate-model-of-dss-induced-colitis
#18
Assunta Liberti, Ivana Zucchetti, Daniela Melillo, Diana Skapura, Yoshimi Shibata, Rosaria De Santis, Maria Rosaria Pinto, Gary W Litman, Larry J Dishaw
The gastrointestinal tract of Ciona intestinalis, a solitary tunicate that siphon filters water, shares similarities with its mammalian counterpart. The Ciona gut exhibits other features that are unique to protochordates, including certain immune molecules, and other characteristics, e.g. chitin-rich mucus, which appears to be more widespread than considered previously. Exposure of Ciona to dextran sulphate sodium (DSS) induces a colitis-like phenotype similar to that seen in other systems and is characterized by alteration of epithelial morphology and infiltration of blood cells into lamina propria like regions...
December 8, 2017: Biology Open
https://www.readbyqxmd.com/read/29222030/regional-ventilation-distribution-and-dead-space-in-anaesthetised-horses-treated-with-and-without-continuous-positive-airway-pressure-novel-insights-by-electrical-impedance-tomography-and-volumetric-capnography
#19
Martina Mosing, Ulrike Auer, Paul MacFarlane, David Bardell, Johannes P Schramel, Stephan H Böhm, Regula Bettschart-Wolfensberger, Andreas D Waldmann
OBJECTIVE: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) on regional distribution of ventilation and dead space in anaesthetized horses. STUDY DESIGN: Randomized, experimental, crossover study. ANIMALS: A total of eight healthy adult horses. METHODS: Horses were anaesthetized twice with isoflurane in 50% oxygen and medetomidine as continuous infusion in dorsal recumbency, and administered in random order either CPAP (8 cmH2O) or NO CPAP for 3 hours...
July 3, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29221725/protective-effects-of-polyphenol-rich-infusions-from-carob-ceratonia-siliqua-leaves-and-cladodes-of-opuntia-ficus-indica-against-inflammation-associated-with-diet-induced-obesity-and-dss-induced-colitis-in-swiss-mice
#20
Ikram Aboura, Abdelhafid Nani, Meriem Belarbi, Babar Murtaza, Aurélie Fluckiger, Adélie Dumont, Chahid Benammar, Moufida Saidani Tounsi, François Ghiringhelli, Mickaël Rialland, Naim Akhtar Khan, Aziz Hichami
In the present study, we have investigated the effects of polyphenol-rich infusions from carob leaves and OFI-cladodes on inflammation associated with obesity and dextran sulfate sodium (DSS)-induced ulcerative colitis in Swiss mice. In vitro studies revealed that aqueous extracts of carob leaves and OFI-cladodes exhibited anti-inflammatory properties marked by the inhibition of IL-6, TNF-α and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells concomitant with NF-κβ nucleus translocation inhibition...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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