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https://www.readbyqxmd.com/read/29450754/neural-invasion-is-a-significant-contributor-to-peritoneal-recurrence-in-signet-ring-cell-gastric-carcinoma
#1
Dakeun Lee, Sang-Yong Son, Young-Bae Kim, Sang-Uk Han, Hoon Hur
BACKGROUND: Gastric signet ring cell carcinoma (SRC) has shown a favorable outcome in early stages but has a worse prognosis than non-SRC in advanced stages. However, the cause for this stage-dependent prognostic impact has not been determined. This study aimed to compare clinicopathologic features and recurrence patterns between gastric SRC and non-SRC in a cohort of Eastern patients. METHODS: This study reviewed the prospectively collected data of 764 patients undergoing curative resection for gastric cancer from 2005 to 2008...
February 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29449535/norisoboldine-a-natural-ahr-agonist-promotes-treg-differentiation-and-attenuates-colitis-via-targeting-glycolysis-and-subsequent-nad-sirt1-suv39h1-h3k9me3-signaling-pathway
#2
Qi Lv, Kai Wang, Simiao Qiao, Ling Yang, Yirong Xin, Yue Dai, Zhifeng Wei
Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells. Under UC condition, hypoxia widely exists in colonic mucosa, and secondary changes of microRNAs (miRs) expressions and glycolysis contribute to Treg differentiation. At present, we worked for exploring the deep mechanisms for NOR-promoted Treg differentiation in hypoxia and its subsequent anti-UC action from the angle of AhR/miR or AhR/glycolysis axis...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29448300/identification-of-preoperative-factors-associated-with-outcomes-following-surgical-management-of-intra-abdominal-recurrent-or-metastatic-gist-following-neoadjuvant-tyrosine-kinase-inhibitor-therapy
#3
Christina L Roland, Brian K Bednarski, Kelsey Watson, Keila E Torres, Janice N Cormier, Wei-Lien Wang, Alexander J Lazar, Neeta Somaiah, Kelly K Hunt, Barry W Feig
BACKGROUND: The role of surgical resection in the treatment of patients with metastatic/recurrent gastrointestinal stromal tumors (GIST) is unclear. The aim of this study was to identify preoperative factors associated with oncologic outcomes for recurrent/metastatic GIST after tyrosine kinase inhibitor (TKI) therapy. METHODS: We identified 107 patients with metastatic or recurrent GIST treated with TKIs and surgical resection (2002-2012). Patients that underwent palliative or incomplete resection were excluded...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29448206/regulation-of-jak2-stat3-and-nf-%C3%AE%C2%BAb-signal-transduction-pathways-veronica-polita-alleviates-dextran-sulfate-sodium-induced-murine-colitis
#4
Md Rashedunnabi Akanda, Hyeon-Hwa Nam, Weishun Tian, Anowarul Islam, Byung-Kil Choo, Byung-Yong Park
Ulcerative colitis (UC) is a major inflammatory bowel disease (IBD) has become a worldwide emergent disease. Veronica polita (VP) is a medicinal herb that has strong antioxidant and anti-inflammatory properties. In the present study, we studied the protective effect of VP on dextran sulfate sodium (DSS)-induced experimental colitis in mice. Phytochemical screening of VP extract demonstrated the presence of high total phenolic and flavonoid contents. Compared with the DSS group, VP significantly reduced clinical symptoms with less weight loss, bloody stool, shortening of the colon, and the severity of colitis was considerably inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in the colon and spleen...
February 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29447434/alterations-in-melatonin-and-serotonin-signalling-in-the-colonic-mucosa-of-mice-with-dextran-sodium-sulfate-induced-colitis
#5
Sarah J MacEachern, Catherine M Keenan, Evangelia Papakonstantinou, Keith A Sharkey, Bhavik Anil Patel
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) is characterized by pain, bleeding, cramping and altered gastrointestinal (GI) function. Changes in mucosal serotonin (5-HT) signalling occur in animal models of colitis and in humans suffering from IBD. Melatonin is co-released with 5-HT from the mucosa and has a wide variety of actions in the GI tract. Here we examined how melatonin signalling is affected by colitis and determined how this relates to 5-HT signalling. EXPERIMENTAL APPROACH: Using electroanalytical approaches, we investigated how 5-HT release, reuptake and availability as well as melatonin availability are altered in dextran sodium sulfate (DSS)-induced colitis in mice...
February 15, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29447178/joint-ancestry-and-association-test-indicate-two-distinct-pathogenic-pathways-involved-in-classical-dengue-fever-and-dengue-shock-syndrome
#6
Marisa Oliveira, Worachart Lert-Itthiporn, Bruno Cavadas, Verónica Fernandes, Ampaiwan Chuansumrit, Orlando Anunciação, Isabelle Casademont, Fanny Koeth, Marina Penova, Kanchana Tangnararatchakit, Chiea Chuen Khor, Richard Paul, Prida Malasit, Fumihiko Matsuda, Etienne Simon-Lorière, Prapat Suriyaphol, Luisa Pereira, Anavaj Sakuntabhai
Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members (PLCB4 added to previously reported PLCE1), related to inflammation of blood vessels. For dengue fever (DF), we found evidence of significant association with CHST10, AHRR, PPP2R5E and GRIP1 genes, which participate in the xenobiotic metabolism signaling pathway...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29445857/superior-and-anterior-hyoid-displacement-during-swallowing-in-non-dysphagic-individuals
#7
James Curtis, Jonelyn Langenstein, Sarah Schneider
The Dynamic Swallow Study (DSS) is a methodology used to objectively and quantitatively assess swallowing kinematics during Videofluoroscopic Swallow Studies (VFSS). No DSS normative data exist delineating superior and anterior hyoid displacement (H sup and H ant , respectively), nor the ratio between H sup and H ant (SA ratio ). The aims of this study were to (1) establish normative data for H sup , H ant , and SA ratio and (2) assess the effects of age, sex, and bolus size on these measures in non-dysphagic patients, within the context of DSS...
February 14, 2018: Dysphagia
https://www.readbyqxmd.com/read/29442390/deciphering-the-biochemical-and-molecular-mechanism-underlying-the-in-vitro-and-in-vivo-chemotherapeutic-efficacy-of-ruthenium-quercetin-complex-in-colon-cancer
#8
Souvik Roy, Rituparna Das, Balaram Ghosh, Tania Chakraborty
Flavonoids are the most investigated phytochemicals due to their pharmacological and therapeutic activities. Their ability to chelate with metal ions has resulted in the emergence of a new category of molecules with a broader spectrum of pharmacological activities. In this study, the ruthenium quercetin complex has been synthesised and anticancer activity has been evaluated on a well-defined model of DMH followed by DSS induced rat colon cancer and on human colon cancer cell line HT-29. The characterizations accomplished through UV-visible, NMR, IR, Mass spectra and XRD techniques and antioxidant activity was assessed by DPPH, FRAP and ABTS methods...
February 14, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29441695/protein-phosphatase-2a-pp2a-inhibitor-cip2a-indicates-resistance-to-radiotherapy-in-rectal-cancer
#9
Eva-Maria Birkman, Adam Elzagheid, Terhi Jokilehto, Tuulia Avoranta, Eija Korkeila, Jarmo Kulmala, Kari Syrjänen, Jukka Westermarck, Jari Sundström
Preoperative (chemo)radiotherapy, (C)RT, is an essential part of the treatment of rectal cancer patients, but tumor response to this therapy among patients is variable. Thus far, there are no clinical biomarkers that could be used to predict response to (C)RT or to stratify patients into different preoperative treatment groups according to their prognosis. Overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) has been demonstrated in several cancers and is frequently associated with reduced survival...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29440876/research-of-an-emergency-medical-system-for-mass-casualty-incidents-in-shanghai-china-a-system-dynamics-model
#10
Wenya Yu, Yipeng Lv, Chaoqun Hu, Xu Liu, Haiping Chen, Chen Xue, Lulu Zhang
Objectives: Emergency medical system for mass casualty incidents (EMS-MCIs) is a global issue. However, China lacks such studies extremely, which cannot meet the requirement of rapid decision-support system. This study aims to realize modeling EMS-MCIs in Shanghai, to improve mass casualty incident (MCI) rescue efficiency in China, and to provide a possible method of making rapid rescue decisions during MCIs. Methods: This study established a system dynamics (SD) model of EMS-MCIs using the Vensim DSS program...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29437146/histone-deacetylase-activity-governs-diastolic-dysfunction-through-a-nongenomic-mechanism
#11
Mark Y Jeong, Ying H Lin, Sara A Wennersten, Kimberly M Demos-Davies, Maria A Cavasin, Jennifer H Mahaffey, Valmen Monzani, Chandrasekhar Saripalli, Paolo Mascagni, T Brett Reece, Amrut V Ambardekar, Henk L Granzier, Charles A Dinarello, Timothy A McKinsey
There are no approved drugs for the treatment of heart failure with preserved ejection fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We demonstrate that ITF2357 (givinostat), a clinical-stage inhibitor of histone deacetylase (HDAC) catalytic activity, is efficacious in two distinct murine models of diastolic dysfunction with preserved EF. ITF2357 blocked LV diastolic dysfunction due to hypertension in Dahl salt-sensitive (DSS) rats and suppressed aging-induced diastolic dysfunction in normotensive mice...
February 7, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29436280/clinicopathologic-characteristics-and-survival-outcomes-in-floor-of-mouth-squamous-cell-carcinoma-a-population-based-study
#12
Satvir Saggi, Karam W Badran, Albert Y Han, Edward C Kuan, Maie A St John
Objective To describe the determinants of survival for patients with floor of mouth (FOM) squamous cell carcinoma (SCC) from 1973 to 2013 with the SEER database (Surveillance, Epidemiology, and End Results). Study Design and Setting Retrospective cohort study with a national database. Subjects and Methods The SEER registry was utilized to calculate survival trends for patients with FOM SCC between 1973 and 2013. Patient data were analyzed with respect to age, sex, race, primary site, stage at presentation, tumor size, grade, and treatment modalities (surgery and radiotherapy)...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29434876/a-retrospective-single-center-cohort-study-on-65-patients-with-primary-retroperitoneal-liposarcoma
#13
Yi-Xi Wu, Jun-Yan Liu, Jia-Jia Liu, Peng Yan, Bo Tang, You-Hong Cui, Yong-Liang Zhao, Yan Shi, Ying-Xue Hao, Pei-Wu Yu, Feng Qian
Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue malignancy of the retroperitoneum. To determine the pathological features and the curative effects of surgery in patients with PRPLS, and to elucidate key prognostic factors, the present study retrospectively analyzed the clinical cases of 65 patients with PRPLS. Immunohistochemical analysis demonstrated that vimentin and Ki-67 are better indicators for PRPLS immunohistochemical diagnosis compared with S-100 protein. S-100 protein was predominantly expressed in well-differentiated PRPLS...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433875/alterations-in-cancer-stem-cell-marker-cd44-expression-predict-oncologic-outcome-in-soft-tissue-sarcomas
#14
Timothy Henderson, Mingyi Chen, Morgan A Darrow, Chin-Shang Li, Chi-Lu Chiu, Arta M Monjazeb, William J Murphy, Robert J Canter
BACKGROUND: Cancer stem cells (CSCs) have been shown to resist chemotherapy and promote metastasis after cytotoxic therapies. We sought to determine if the expression of CSC markers (aldehyde dehydrogenase [ALDH], CD44, and epidermal growth factor receptor [EGFR]) predicted outcomes in soft-tissue sarcoma (STS) patients. METHODS: We queried an institutional database of 23 STS patients and evaluated immunohistochemical expression of CSC markers ALDH, CD44, and EGFR...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433567/laryngeal-recurrence-sites-in-patients-previously-treated-with-transoral-laser-microsurgery-for-squamous-cell-carcinoma
#15
P Horwich, M H Rigby, C MacKay, J Melong, B Williams, M Bullock, R Hart, J Trites, S M Taylor
BACKGROUND: The laryngeal framework provides a natural barrier preventing tumour spread to extralaryngeal structures. Transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma (SCC) may violate these boundaries, altering the pathways of tumor spread for potential recurrences. Our project objective is to describe laryngeal SCC recurrence patterns and overall survival in patients requiring total laryngectomy (TL) after TLM. METHODS: Patients undergoing TLM for laryngeal SCC requiring salvage TL were identified from a prospective CO2 laser database containing all patients undergoing TLM for head and neck malignancies at the QEII Health Sciences Center in Halifax, Nova Scotia between March 2002 - May 2014...
February 13, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29433203/physicochemical-and-nutraceutical-properties-of-moringa-moringa-oleifera-leaves-and-their-effects-in-an-in-vivo-aom-dss-induced-colorectal-carcinogenesis-model
#16
M L Cuellar-Nuñez, I Luzardo-Ocampo, R Campos-Vega, M A Gallegos-Corona, E González de Mejía, G Loarca-Piña
Moringa (Moringa oleifera) is a plant that has generated great interest in recent years because of its attributed medicinal properties. The aim of this study was to characterize the bioactive compounds of moringa leaves (MO) and evaluate their effect on a colorectal carcinogenesis model. Twenty-four male CD-1 mice were divided into 4 groups: Group 1 fed with basal diet (negative control/NC); Group 2 received AOM/DSS (positive control); Groups 3 and 4 were fed with basal diet supplemented with moringa leaves (2...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429963/impact-of-comorbidity-on-tolerability-and-survival-following-curative-intent-intensity-modulated-radiotherapy-in-older-patients-with-nasopharyngeal-cancer
#17
Kiattisa Sommat, Nelson Ling Fung Yit, Fuqiang Wang, John Heng Chi Lim
OBJECTIVE: This study aimed to evaluate the predictive factors for survival and acute toxicities in older patients with NPC treated with curative intent IMRT. MATERIALS AND METHODS: Older patients aged 65 years and above with non-metastatic NPC treated with curative intent IMRT between 2003 and 2013 were retrospectively analysed. Variables examined were gender, age, overall stage, chemotherapy use, Eastern Cooperative Oncology Group (ECOG) performance status and comorbidity...
February 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29427627/anti-inflammatory-actions-of-caesalpinin-m2-in-experimental-colitis-as-a-selective-glucocoricoid-receptor-modulator
#18
Gang Xiang, Minmin Fan, Yuzhu Ma, Miao Wang, Jian Gao, Jingwei Chen, Xin Li, Wenwen Xue, Yixuan Wang, Huiyuan Gao, Yan Shen, Qiang Xu
Although repression of inflammatory gene expression makes glucocoricoids (GCs) powerful anti-inflammatory agents, side effects limit usage and drive the search for improved glucocoricoid receptor (GR) ligands. It has been postulated that the anti-inflammatory effects of GCs are primarily mediated by GR's activity in transrepressing major inflammation pathways such as NF-κB pathway, whereas their side effects are mostly mediated by GR's transactivation. In this study, we found that Caesalpinin M2 (C-M2), a cassane furanoditerpene isolated from a Chinese medical plant, exerts an anti-inflammatory potential both in vitro and in vivo...
February 7, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29423390/dual-effects-of-high-protein-diet-on-mouse-skin-and-colonic-inflammation
#19
Xuelei Cui, Eunjung Kim
Chronic inflammation is a major etiology of cancer. Accumulating epidemiological and experimental evidences suggest that intake of high protein diet (HPD) is associated with colitis-associated colon cancer, however, most of the studies were confined in colon. Systemic influence of HPD on inflammation indices in different tissues of an organism has never been studied. We therefore investigated the effect of HPD on mouse skin and colonic inflammation using the well characterized inflammation induction protocol in both tissues (12- O -tetradecanoylphorbol-13-acetate [TPA] for skin and dextran sodium sulfate [DSS] for colon)...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29423097/primary-breast-diffuse-large-b-cell-lymphoma-a-population-based-study-from-1975-to-2014
#20
Yijun Jia, Chenbo Sun, Zebing Liu, Weige Wang, Xiaoyan Zhou
Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin's lymphoma with limited data. In this study, a population-based study of primary breast DLBCL in the United States was performed to determine its incidence trends, prognostic factors, survival, the role of surgery as well as the comparison with nodal DLBCL. 1021 patients diagnosed with breast DLBCL were identified in the Surveillance, Epidemiology, and End Results (SEER) cancer registries from 1973-2014. The incidence of both breast and nodal DLBCL increased over time...
January 9, 2018: Oncotarget
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