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https://www.readbyqxmd.com/read/28821031/surface-deacetylated-chitin-nanofibers-reinforced-with-a-sulfobutyl-ether-%C3%AE-cyclodextrin-gel-loaded-with-prednisolone-as-potential-therapy-for-inflammatory-bowel-disease
#1
Ryo Tabuchi, Makoto Anraku, Daisuke Iohara, Takako Ishiguro, Shinsuke Ifuku, Tomone Nagae, Kaneto Uekama, Shoko Okazaki, Keizo Takeshita, Masaki Otagiri, Fumitoshi Hirayama
Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE-β-CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. PD was released slowly from the gel at both pH 1.2 and 6.8. The in vitro slow release of PD from the NFs-CDs gel was reflected in the in vivo absorption of the drug after oral administration to rats. These results suggest that a simple gel composed of a mixture of SDACNFs and SBE-β-CD has the potential for use in the controlled release of PD...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820392/orally-administered-angiotensin-converting-enzyme-inhibitors-captopril-and-isoleucine-proline-proline-have-distinct-effects-on-local-renin-angiotensin-system-and-corticosterone-synthesis-in-dextran-sulfate-sodium-induced-colitis-in-mice
#2
H Salmenkari, M Holappa, R A Forsgard, R Korpela, H Vapaatalo
The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28817583/dextran-sodium-sulfate-dss-induces-necrotizing-enterocolitis-like-lesions-in-neonatal-mice
#3
Marco Ginzel, Xiaoyan Feng, Joachim F Kuebler, Christian Klemann, Yi Yu, Reinhard von Wasielewski, Joon-Keun Park, Mathias W Hornef, Gertrud Vieten, Benno M Ure, Torsten Kaussen, Jan Hendrik Gosemann, Steffi Mayer, Anne Suttkus, Martin Lacher
BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory bowel disease of preterm human newborns with yet unresolved etiology. An established neonatal murine model for NEC employs oral administration of lipopolysaccharides (LPS) combined with hypoxia/hypothermia. In adult mice, feeding dextran sodium sulfate (DSS) represents a well-established model for experimental inflammatory bowel disease. Here we investigated the effect of DSS administration on the neonatal murine intestine in comparison with the established NEC model...
2017: PloS One
https://www.readbyqxmd.com/read/28815443/endoscopic-ultrasound-as-a-pretreatment-clinical-staging-tool-for-gastric-cancer-association-with-pathology-and-outcome
#4
Ryan P Merkow, Gabriel Herrera, Debra A Goldman, Hans Gerdes, Mark A Schattner, Arnold J Markowitz, Vivian E Strong, Murray F Brennan, Daniel G Coit
BACKGROUND: Endoscopic ultrasound (EUS) is a guideline-recommended diagnostic test to estimate pretreatment clinical stage in gastric cancer. The impact of EUS to discriminate long-term outcomes has not been established. OBJECTIVES: The objectives of our study were to (1) evaluate the association between EUS and pathologic stage; (2) evaluate the ability of EUS to predict disease-specific survival (DSS); and (3) determine how neoadjuvant chemotherapy (NCT) affects these relationships...
August 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28812128/protective-effect-of-cigarette-smoke-on-the-course-of-dextran-sulfate-sodium-induced-colitis-is-accompanied-by-lymphocyte-subpopulation-changes-in-the-blood-and-colon
#5
Jaroslaw Daniluk, Urszula Daniluk, Joanna Reszec, Malgorzata Rusak, Milena Dabrowska, Andrzej Dabrowski
BACKGROUND: Cigarette smoke (CS) exerts protective effect against ulcerative colitis. The mechanism of this phenomenon remains unknown. One of the possible explanation by which CS exerts its anti-inflammatory action is modulation of immune system. Therefore, the aim of the study was to evaluate the effect of CS on the course of inflammation and subpopulations of lymphocytes in the blood and colon in mice with dextran sulfate sodium (DSS)-induced colitis. METHODS: C57BL6/cmdb mice were exposed to CS for 4 weeks...
August 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28810551/alterations-in-biomechanical-properties-and-microstructure-of-colon-wall-in-early-stage-experimental-colitis
#6
Xiaohui Gong, Xiaojuan Xu, Sisi Lin, Yu Cheng, Jianhua Tong, Yongyu Li
The aim of the current study was to investigate the effects of early-stage dextran sodium sulfate (DSS)-induced mouse colitis on the biomechanical properties and microstructure of colon walls. In the present study, colitis was induced in 8-week-old mice by the oral administration of DSS, and then 10 control and 10 experimental colitis samples were harvested. Uniaxial tensile tests were performed to measure the ultimate tensile strength and ultimate stretches of colon tissues. In addition, histological investigations were performed to characterize changes in the microstructure of the colon wall following treatment...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808878/role-of-intestinal-microbiome-in-american-ginseng-mediated-colon-cancer-protection-in-high-fat-diet-fed-aom-dss-mice
#7
C-Z Wang, W-H Huang, C-F Zhang, J-Y Wan, Y Wang, C Yu, S Williams, T-C He, W Du, M W Musch, E B Chang, C-S Yuan
OBJECTIVE: Chronic intestinal inflammation is a risk factor for colorectal cancer (CRC) initiation and development. Diets that are rich in Western style fats have been shown to promote CRC. This study was conducted to investigate the role of intestinal microbiome in American ginseng-mediated CRC chemoprevention in a mouse model. The population and diversity of enteric microbiome were evaluated after the ginseng treatment. METHODS: Using an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced gut inflammation and tumorigenesis mouse model, the effects of oral American ginseng on high fat diet-associated enteric pathology were determined...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28805735/dietary-propolis-ameliorates-dextran-sulfate-sodium-induced-colitis-and-modulates-the-gut-microbiota-in-rats-fed-a-western-diet
#8
Kai Wang, Xiaolu Jin, Mengmeng You, Wenli Tian, Richard K Le Leu, David L Topping, Michael A Conlon, Liming Wu, Fuliang Hu
Propolis is an important hive product and considered beneficial to health. However, evidence of its potential for improving gut health is still lacking. Here we use rats to examine whether dietary supplementation with propolis could be used as a therapy for ulcerative colitis. Rats were fed with a Western style diet alone (controls) or supplemented with different amounts of Chinese propolis (0.1%, 0.2%, and 0.3%) to examine effects on acute colitis induced by 3% dextran sulphate sodium (DSS) in drinking water...
August 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28804705/possible-involvement-of-liver-resident-macrophages-kupffer-cells-in-the-pathogenesis-of-both-intrahepatic-and-extrahepatic-inflammation
#9
Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe
Liver resident macrophages designated Kupffer cells (KCs) form the largest subpopulation of tissue macrophages. KCs are involved in the pathogenesis of liver inflammation. However, the role of KCs in the systemic inflammation is still elusive. In this study, we examined whether KCs are involved in not only intrahepatic inflammation but also extrahepatic systemic inflammation. Administration of clodronate liposomes resulted in the KC deletion and in the suppression of liver injury in T cell-mediated hepatitis by ConA as a local acute inflammation model, while the treatment did not influence dextran sulfate sodium- (DSS-) induced colitis featured by weight loss, intestinal shrink, and pathological observation as an ectopic local acute inflammation model...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28804459/metabolic-variability-of-a-multispecies-probiotic-preparation-impacts-on-the-anti-inflammatory-activity
#10
Michele Biagioli, Luca Laghi, Adriana Carino, Sabrina Cipriani, Eleonora Distrutti, Silvia Marchianò, Carola Parolin, Paolo Scarpelli, Beatrice Vitali, Stefano Fiorucci
Background: In addition to strain taxonomy, the ability of probiotics to confer beneficial effects on the host rely on a number of additional factors including epigenetic modulation of bacterial genes leading to metabolic variability and might impact on probiotic functionality. Aims: To investigate metabolism and functionality of two different batches of a probiotic blend commercialized under the same name in Europe in models of intestinal inflammation. Methods: Boxes of VSL#3, a probiotic mixture used in the treatment of pouchitis, were obtained from pharmacies in UK subjected to metabolomic analysis and their functionality tested in mice rendered colitis by treatment with DSS or TNBS...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28802904/baicalin-may-alleviate-inflammatory-infiltration-in-dextran-sodium-sulfate-induced-chronic-ulcerative-colitis-via-inhibiting-il-33-expression
#11
Cheng-Liang Zhang, Si Zhang, Wen-Xi He, Jing-Li Lu, Yan-Jiao Xu, Jin-Yu Yang, Dong Liu
AIMS: To investigate the therapeutic effect of baicalin treatment in chronic ulcerative colitis (UC), and explore the potential anti-inflammation mechanism(s) via IL-33 pathway. MAIN METHODS: UC model were established by giving three cycles of 5-day 2% Dextran sodium sulfate (DSS) with two intervals of 14-day recovery in mice, totaling 43days. At the 13th day of the UC modeling, mice received baicalin at doses of 50, 100, or 150mg/kg, respectively. Disease activity index (DAI) assessment as well as HE and PAS staining were performed...
August 9, 2017: Life Sciences
https://www.readbyqxmd.com/read/28802390/pediatric-head-and-neck-bone-sarcomas-an-analysis-of-204-cases
#12
Jacob S Brady, Sei Y Chung, Emily Marchiano, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To analyze the demographics, survival, and treatment efficacy of pediatric sarcomas of the facial skeleton and skull. METHODS: Retrospective study of cases from the US National Cancer Institute's Surveillance, Epidemiology, and End Results database. Pediatric patients between the ages of 0 and 18 diagnosed with a malignant sarcoma of either the mandible or the bones of skull, face, and associated joints from 1973 to 2013 were studied. RESULTS: In total, 204 patients were included in the analysis...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802151/sodium-butyrate-inhibits-the-nf-kappa-b-signaling-pathway-and-histone-deacetylation-and-attenuates-experimental-colitis-in-an-il-10-independent-manner
#13
Changhyun Lee, Byeong Gwan Kim, Jee Hyun Kim, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim
Butyrate is a bacterial metabolite of dietary fiber in the colon that has been used to treat inflammatory disease. However, the effect of oral supplementation with butyrate on colitis has not been fully explored. We evaluated the effects of and mechanisms underlying oral supplementation with butyrate on experimental murine colitis. In an in vitro study, we found that LPS induced the secretion of cytokines (i.e., IL-8 in COLO 205; TNF-α, IL-6, IL-12, and IL-10 in RAW 264.7; and TNF-α, IL-6 and IL-12 in peritoneal macrophages obtained from IL-10-deficient [IL-10(-/-)] mice)...
August 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28801721/surgery-is-essential-in-squamous-cell-cancer-of-the-rectum
#14
D C Steinemann, P C Müller, A T Billeter, T Bruckner, A Ulrich, B P Müller-Stich
PURPOSE: Squamous cell cancer (SCC) is a rare histological subtype of rectal cancer. It is unclear whether SCC should be treated by multimodal therapy, including surgery, or by chemoradiation alone. The objective of the study was to define an optimal treatment strategy. METHODS: Patients with rectal cancer and SCC histology were identified in the Surveillance Epidemiology and End Results Database between 1990 and 2013. According to treatment, three groups were defined: radiotherapy and surgery (RT/SX), radiotherapy (RT), and surgery (SX)...
August 11, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28800645/analysis-of-endogenous-lipids-during-intestinal-wound-healing
#15
Yunna Lee, Jieun Choo, Su Jin Kim, Gwangbeom Heo, Charalabos Pothoulakis, Yong-Hak Kim, Eunok Im
Intestinal wound healing is a new therapeutic goal for inflammatory bowel disease (IBD) as complete healing of the mucosa is the key element of clinical remission in IBD. Previous studies showed that termination of inflammation can be achieved by adding pro-resolving lipids like DHA and EPA exogenously. However, the roles of these lipids in mucosal healing have not been investigated. To recapitulate intestinal healing process, mice were received dextran sodium sulfate (DSS) for 7 days in the drinking water followed by regular tap water for 5 additional days...
2017: PloS One
https://www.readbyqxmd.com/read/28800504/survival-outcomes-and-patterns-of-failure-in-women-with-stage-iiic2-endometrial-carcinoma
#16
Joon K Lee, Meredith Mahan, Rabbie K Hanna, Mohamed A Elshaikh
OBJECTIVES: Para-aortic lymph node involvement in women with endometrial carcinoma (EC) is a poor prognostic factor. Many studies have included women with stage IIIC2 in cohorts of patients with advanced stage disease. The aim of this study was to analyze survival outcomes and patterns of failure in women with solely stage IIIC2 EC. METHODS: We identified women with FIGO stage IIIC2 EC who underwent surgical staging at our institution. In addition to descriptive analyses of patient demographics, tumor characteristics, and adjuvant treatment received, univariate log-rank analyses and Cox regression multivariate analyses (MVA) were performed to identify predictors of recurrence-free (RFS), disease-specific (DSS) and overall survival (OS)...
August 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28800083/effect-of-angelica-sinensis-root-extract-on-cancer-prevention-in-different-stages-of-an-aom-dss-mouse-model
#17
Bochen Zhao, Qian Kang, Yu Peng, Yuanping Xie, Cheng Chen, Bingshao Li, Qing Wu
Angelica sinensis root (ASR) extract was obtained to investigate its effects on colorectal carcinogenesis in different stages of an Azoxymethane/Dextran sodium sulphate (AOM/DSS) model. In this study, we showed that ASR extract administration in the initial stage of the AOM/DSS model had cancer preventive effects with decreasing tumor incidence and a high-grade of intraepithelial neoplasia incidence. With respect to DNA damage, the amounts of 8-oxoguanine and γ-H2AX were suppressed in colon tissue. The balance of apoptosis and proliferation was approaching the normal state...
August 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28796347/clinicopathological-analysis-of-atrx-daxx-and-notch-receptor-expression-in-angiosarcomas
#18
Gauri Panse, John S A Chrisinger, Cheuk H Leung, Davis R Ingram, Samia Khan, Khalida Wani, Heather Lin, Alexander J Lazar, Wei-Lien Wang
AIMS: Multiple genetic alterations including alternative lengthening of telomeres (ALT) and NOTCH mutations have been described in angiosarcoma. Loss of ATRX (α-thalessemia/mental retardation syndrome X-linked) and DAXX (death domain-associated 6) expression is frequently associated with the ALT phenotype. Additionally, inhibition of NOTCH signaling induces malignant vascular tumors in mice, indicating a tumor suppressive role of the NOTCH pathway in the pathogenesis of angiosarcoma...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28795969/e-cadherin-mediates-the-preventive-effect-of-vitamin-d3-in-colitis-associated-carcinogenesis
#19
Yu Xin, Longmei He, Zijian Luan, Hong Lv, Hong Yang, Ying Zhou, Xinhua Zhao, Weixun Zhou, Songlin Yu, Bei Tan, Hongying Wang, Jiaming Qian
Vitamin D3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. Here, we evaluated if vitamin D3 has a preventive effect on colitis-associated carcinogenesis. Administration of azoxymethane (AOM), followed with dextran sulfate sodium (DSS), was used to simulate colitis-associated colon cancer in mice. The supplement of vitamin D3 at different dosages (15, 30, 60 IU·g·w), started before AOM or immediately after DSS treatment (post 60), was sustained to the end of the experiment. Dietary vitamin D3 significantly reduced the number of tumors and tumor burden in a dose-dependent manner...
August 8, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28795364/survival-benefit-of-additional-surgery-after-non-curative-endoscopic-submucosal-dissection-for-early-gastric-cancer-a-propensity-score-matching-analysis
#20
Sho Suzuki, Takuji Gotoda, Waku Hatta, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Tooru Shimosegawa
BACKGROUND AND PURPOSE: Previous studies comparing survival outcomes between patients who did and did not undergo additional surgery after non-curative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) were limited in that the baseline characteristics differed significantly between the groups. We aimed to address this limitation and compared survival outcomes between these two groups using propensity score matching analysis. METHODS: The study enrolled 1969 consecutive patients who underwent non-curative ESD for EGC between 2000 and 2011 at any of 19 institutions across Japan...
August 9, 2017: Annals of Surgical Oncology
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