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https://www.readbyqxmd.com/read/29031130/a-validated-prognostic-biomarker-score-for-adult-patients-with-nonmetastatic-soft-tissue-sarcomas-of-the-trunk-and-extremities
#1
Katja Maretty-Kongstad, Ninna Aggerholm-Pedersen, Johnny Keller, Akmal Safwat
BACKGROUND: The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) adjusted for confounders. METHODS: The study included 818 patients with localized STS. Pretreatment levels of albumin, C-reactive protein, hemoglobin, neutrophils, and lymphocytes were tested individually and combined in prognostic scores: neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), and Aarhus Composite Biomarker Score (ACBS) which includes all five biomarkers...
October 11, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29028547/-borneol-improves-the-efficacy-of-edaravone-against-dss-induced-colitis-by-promoting-m2-macrophages-polarization-via-jak2-stat3-signaling-pathway
#2
Xiong Zhang, Fang Xu, Li Liu, Lili Feng, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu
Compound edaravone injection (C.EDA), a compound preparation composed of edaravone (EDA) and (+)-Borneol with the mass ratio of 4: 1, displays a better anti-inflammatory activity than EDA. However, its precise mechanism remains to be further studied. In this work, we investigated whether (+)-Borneol could improve the efficacy of EDA against DSS-induced colitis. We found that C.EDA at 7.5 and 15mg/kg could significantly relieve the disease activity index (DAI) and reduce the loss of body weight and colon length in a dose-dependent manner, while EDA or (+)-Borneol alone only had moderate effects even at the highest dose...
October 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29027650/correction-to-role-of-intestinal-microbiome-in-american-ginseng-mediated-colon-cancer-prevention-in-high-fat-diet-fed-aom-dss-mice
#3
C-Z Wang, W-H Huang, C-F Zhang, J-Y Wan, Y Wang, C Yu, S Williams, T-C He, W Du, M W Musch, E B Chang, C-S Yuan
This article was originally published with the wrong title.
October 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29026145/cibinetide-dampens-innate-immune-cell-functions-thus-ameliorating-the-course-of-experimental-colitis
#4
Manfred Nairz, David Haschka, Stefanie Dichtl, Thomas Sonnweber, Andrea Schroll, Malte Aßhoff, John E Mindur, Patrizia L Moser, Dominik Wolf, Filip K Swirski, Igor Theurl, Anthony Cerami, Michael Brines, Günter Weiss
Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor cells. In other cell types, including immune cells, EPOR and the ß-common receptor (CD131) form heteromers (the innate repair receptor; IRR), and exert tissue protective effects. We used dextran sulphate sodium (DSS) to induce colitis in C57BL/6 N mice. Once colitis was established, mice were treated with solvent, EPO or the selective IRR agonist cibinetide...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025731/macrophage-depletion-using-clodronate-liposomes-decreases-tumorigenesis-and-alters-gut-microbiota-in-the-aom-dss-mouse-model-of-colon-cancer
#5
Jackie E Bader, Reilly T Enos, Kandy T Velazquez, Meredith S Carson, Mitzi Nagarkatti, Prakash S Nagarkatti, Ioulia Chatzistamou, J Mark Davis, James A Carson, Cory Robinson, E Angela Murphy
We examined the role of macrophages in inflammation associated colorectal cancer (CRC). Given the emerging evidence on immune-microbiota interactions in CRC, we also sought to examine the interaction between macrophages and gut microbiota. To induce CRC, male C57BL/6 mice (n=32) received a single injection of azoxymethane (AOM) followed by three cycles of dextran sodium sulfate (DSS) supplemented water at weeks 1, 4, and 7, respectively. Prior to the final DSS cycle (week 7) and twice weekly until sacrifice, mice (n=16/group) received either 200μl i...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29024491/surgical-morbidity-and-mortality-in-patients-after-microvascular-reconstruction-for-head-and-neck-cancer
#6
Young-Hoon Joo, Kwang-Jae Cho, Jun-Ook Park, Sang-Yeon Kim, Min-Sik Kim
OBJECTIVES: The aim was to evaluate the importance of clinical factors in the prediction of postoperative complications in patients with microvascular reconstruction for head and neck squamous cell cancer (HNSCC). DESIGN: A retrospective review of case notes was performed. SETTING: Patients treated at a single institute. PARTICIPANTS: The present study included 259 patients with HNSCC treated with radical surgery and microvascular reconstruction between 1993 and 2014...
October 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29019858/epicutaneous-tolerance-induction-to-a-bystander-antigen-abrogates-colitis-and-ileitis-in-mice
#7
David Dunkin, M Cecilia Berin, Lucie Mondoulet, Steven Tobar, Garabet Yeretssian, Leticia Tordesillas, Alina Iuga, Thibaut Larcher, Virginia Guillespie, Pierre-Henri Benhamou, Jean-Frederic Colombel, Hugh A Sampson
BACKGROUND: Although inflammatory bowel disease (IBD) is a failure in maintaining tolerance to the intestinal microbiota, few studies have investigated the use of immunologic tolerance as a treatment approach for IBD. We hypothesized that induction of immune tolerance at a distal site could suppress intestinal inflammation through a process of bystander regulation. METHODS: Epicutaneous tolerance was induced by topical application of ovalbumin (OVA) using a Viaskin patch for 48 hours...
October 9, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29018816/comparative-evaluation-between-sulfasalazine-alone-and-in-combination-with-herbal-medicine-on-dss-induced-ulcerative-colitis-mice
#8
Mi-Rae Shin, Kyeong Jo Kim, Soo Hyun Kim, Su Ji Kim, Bu-Il Seo, Hyo-Jin An, Seong-Soo Roh
The present study aimed to investigate the comparative evaluation of pharmacological efficacy between sulfasalazine alone and sulfasalazine in combination with herbal medicine on dextran sodium sulfate- (DSS-) induced UC in mice. Balb/c mice received 5% DSS in drinking water for 7 days to induce colitis. Animals were divided into five groups (n = 9): Group I (normal group), Group II (DSS control group), Group III (DSS + sulfasalazine (30 mg/kg)), Group IV (DSS + sulfasalazine (60 mg/kg)), and Group V (DSS + sulfasalazine (30 mg/kg) + Cinnamomi Cortex and Bupleuri Radix mixture (30 mg/kg) (SCB))...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29018440/human-gut-symbiont-roseburia-hominis-promotes-and-regulates-innate-immunity
#9
Angela M Patterson, Imke E Mulder, Anthony J Travis, Annaig Lan, Nadine Cerf-Bensussan, Valerie Gaboriau-Routhiau, Karen Garden, Elizabeth Logan, Margaret I Delday, Alistair G P Coutts, Edouard Monnais, Vanessa C Ferraria, Ryo Inoue, George Grant, Rustam I Aminov
OBJECTIVE: Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of R. hominis-host cross talk using both murine and in vitro models. DESIGN: The complete genome sequence of R. hominis A2-183 was determined. C3H/HeN germ-free mice were mono-colonized with R...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017830/suvmax-after-18-fluoro-deoxyglucose-positron-emission-tomography-computed-tomography-a-tool-to-define-treatment-strategies-in-pancreatic-cancer
#10
Ilaria Pergolini, Stefano Crippa, Matteo Salgarello, Giulio Belfiori, Stefano Partelli, Giacomo Ruffo, Alessandro Pucci, Giuseppe Zamboni, Massimo Falconi
BACKGROUND: (18)fluoro-deoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) might be a useful tool in the management of pancreatic ductal adenocarcinoma (PDAC). AIMS: The aim of this study was to analyze maximum standard uptake value (SUVmax) after 18FDG-PET/CT as predictor of survival outcomes and method to determine treatment strategies. METHODS: A consecutive series of patients who underwent preoperative 18FDG-PET/CT and subsequent resection for PDAC were retrospectively reviewed...
September 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29017096/enhancing-mir-132-expression-by-aryl-hydrocarbon-receptor-attenuates-tumorigenesis-associated-with-chronic-colitis
#11
Abdullah M Alzahrani, Hamza Hanieh, Hairul-Islam Mohamed Ibrahim, Omar Mohafez, Tamer Shehata, Mohammad Bani Ismail, Manal Alfwuaires
BACKGROUND: Chronic inflammation in ulcerative colitis (UC) patients is the major risk factor for colitis-associated colon cancer (CAC). Recent evidences have shown that microRNAs (miRNAs) are implicated in CAC pathogenesis. However, the interaction of miRNAs with the transcription factors that alleviate CAC has not been reported. METHODS: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3'-diindolylmethane (DIM) were used to activate aryl hydrocarbon receptor (Ahr) in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC in mice...
October 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28991483/vasoactive-intestinal-peptide-nanomedicine-for-the-management-of-inflammatory-bowel-disease
#12
Dulari Jayawardena, Arivarasu N Anbazhagan, Grace Guzman, Pradeep K Dudeja, Hayat Onyuksel
Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine, with increasing incidence worldwide. At present, the management of IBD is an unmet medical need due to the ineffectiveness of currently available drugs in treating all patients and there is strong demand for novel therapeutics. In this regard, vasoactive intestinal peptide, a potent anti-inflammatory endogenous hormone, has shown promise in managing multiple immune disorders in animal models. However, when administered in the free form, VIP undergoes rapid degradation in vivo, and with continuous infusion, causes severe dose limiting side effects...
October 9, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28991196/phaseolus-acutifolius-lectin-fractions-exhibit-apoptotic-effects-on-colon-cancer-preclinical-studies-using-dimethilhydrazine-or-azoxi-methane-as-cancer-induction-agents
#13
Ulisses Moreno-Celis, Josué López-Martínez, Alejandro Blanco-Labra, Ricardo Cervantes-Jiménez, Laura Elena Estrada-Martínez, Alejandro Eduardo García-Pascalin, María De Jesús Guerrero-Carrillo, Adriana Jheny Rodríguez-Méndez, Carmen Mejía, Roberto Augusto Ferríz-Martínez, Teresa García-Gasca
Phaseolus acutifolius (Tepary bean) lectins have been studied as cytotoxic molecules on colon cancer cells. The toxicological profile of a Tepary bean lectin fraction (TBLF) has shown low toxicity in experimental animals; exhibiting anti-nutritional effects such as a reduction in body weight gain and a decrease in food intake when using a dose of 50 mg/kg on alternate days for six weeks. Taking this information into account, the focus of this work was to evaluate the effect of the TBLF on colon cancer using 1,2-dimethylhydrazine (DMH) or azoxy-methane/dextran sodium sulfate (AOM/DSS) as colon cancer inductors...
October 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28989104/epidemiology-of-malignant-cutaneous-granular-cell-tumors-a-united-states-population-based-cohort-analysis-using-the-surveillance-epidemiology-and-end-results-seer-database
#14
Fatima N Mirza, Charles T Tuggle, Cheryl K Zogg, Humza N Mirza, Deepak Narayan
BACKGROUND: Malignant cutaneous granular cell tumors (mcGCT) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies. OBJECTIVE: To examine the incidence, secondary malignancies, treatment, overall survival (OS), and disease-specific survival (DSS) of patients with mcGCT. METHODS: A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results (SEER) database, 1973-2013, for patients diagnosed with mcGCT...
October 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28987931/anti-inflammatory-effect-of-glucose-lysine-maillard-reaction-products-on-intestinal-inflammation-model-in-vivo
#15
Chung-Oui Hong, Chae Hong Rhee, Min Cheol Pyo, Kwang-Won Lee
Inflammatory bowel diseases (IBDs) are chronic disorders that are characterized by intestinal epithelial inflammation and injury. Currently, the most employed therapies are antibiotics and anti-inflammatory drugs; however, the side effects limit long-term effectiveness. We evaluated the impact of glucose-lysine Maillard reaction products (Glc-Lys MRPs) on colitis, induced in rats by an administration of 5% dextran sulfate sodium (DSS) in drinking water. Glc-Lys MRPs ameliorate DSS-induced colitis, as determined by a decrease in disease index activity, colon weight/length ratio, nitric oxide levels in serum, recovery of body weight loss, colon length and serum lysozyme levels...
October 4, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28987717/protective-effect-of-rumenic-acid-rich-cow-s-milk-against-colitis-is-associated-with-the-activation-of-nrf2-pathway-in-a-murine-model
#16
P Bergamo, E Cocca, A Monaco, V Cozzolino, F Boscaino, I Ferrandino, F Maurano, M Rossi
Dietary supplementation with pure cis9, trans11 isomer of Conjugated Linoleic Acid -known as Rumenic Acid (RA)- improves cytoprotective defenses downstream through the activation of nuclear factor-E2-related factor-2(Nrf2). This capability, when Rumenic Acid is consumed in the form of foods, is still unknown. The ability of standard (St) or cow milk naturally-enriched in RA (En) to activate Nrf2 pathway and its impact on dextran sodium sulfate (DSS)-induced colitis was comparatively evaluated. Activity of Nrf2 pathway was investigated in colonic tissue of BALB/c mice, receiving 4-week supplement with skimmed milk (SK), St or St reinforced with pure RA (RSt) providing increasing RA dose (0, 124 or 404mg RA/kg(-1) b...
October 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28987000/microrna-126-deficiency-enhanced-the-activation-and-function-of-cd4-t-cells-by-elevating-irs-1-pathway
#17
Fengyun Chu, Yan Hu, Ya Zhou, Mengmeng Guo, Jia Lu, Wen Zheng, Hualin Xu, Juanjuan Zhao, Lin Xu
Recent evidence showed that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4(+) T cells remains largely unknown. Here we firstly found that the activation and proliferation, as well as the expression of IFN-γ, of CD4(+) T cells from miR-126 knockdown (KD) mice using miRNA-Sponge technique were enhanced significantly in vitro, compared with those in CD4(+) T cells from wild type (WT) mice...
October 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28986764/predictive-and-prognostic-value-of-18f-dopa-pet-ct-in-patients-affected-by-recurrent-medullary-carcinoma-of-the-thyroid
#18
Federico Caobelli, Agostino Chiaravalloti, Laura Evangelista, Giorgio Saladini, Orazio Schillaci, Manuela Vadrucci, Federica Scalorbi, Davide Donner, Pierpaolo Alongi
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a malignancy accounting for about 5-8% of thyroid cancers. Serum calcitonin and carcinoembryonic antigen (CEA) levels are widely used to monitor disease progression. However, prognostic factors able to predict outcomes are highly desirable. We, therefore, aimed to assess the prognostic role of (18)F-DOPA PET/CT in patients with recurrent MTC. MATERIALS AND METHODS: 60 patients (mean age 64 ± 13 years, range 44-82) with recurrent MTC were eligible from a multicenter database...
October 6, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28985227/nanoparticle-curcumin-ameliorates-experimental-colitis-via-modulation-of-gut-microbiota-and-induction-of-regulatory-t-cells
#19
Masashi Ohno, Atsushi Nishida, Yoshihiko Sugitani, Kyohei Nishino, Osamu Inatomi, Mitsushige Sugimoto, Masahiro Kawahara, Akira Andoh
BACKGROUND AND AIMS: Curcumin is a hydrophobic polyphenol derived from turmeric, a traditional Indian spice. Curcumin exhibits various biological functions, but its clinical application is limited due to its poor absorbability after oral administration. A newly developed nanoparticle curcumin shows improved absorbability in vivo. In this study, we examined the effects of nanoparticle curcumin (named Theracurmin) on experimental colitis in mice. METHODS: BALB/c mice were fed with 3% dextran sulfate sodium (DSS) in water...
2017: PloS One
https://www.readbyqxmd.com/read/28983962/etiology-of-developmental-spinal-stenosis-a-genome-wide-association-study
#20
Jason Pui Yin Cheung, Patrick Yp Kao, Pak Sham, Kathryn Se Cheah, Danny Chan, Kenneth Mc Cheung, Dino Samartzis
Our study aimed to identify possible single nucleotide polymorphisms (SNPs) via a genome-wide association study (GWAS) approach and a candidate gene platform that were associated with lumbar developmental spinal stenosis (DSS). Southern Chinese population-based study volunteers were assessed (age range: 18-55 years). DSS was defined as the anteroposterior bony spinal canal diameter on T1-weighted axial MRI of L1 to S1. Genotyping was performed using the Illumina HumanOmniZhongHua-8 BeadChip. Using the canal diameter as the quantitative trait, genomic statistical analyses was performed...
October 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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