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https://www.readbyqxmd.com/read/29667339/adjuvant-chemotherapy-in-patients-with-operable-granulosa-cell-tumors-of-the-ovary-a-surveillance-epidemiology-and-end-results-cohort-study
#1
Anton Oseledchyk, Renee L Gennarelli, Mario M Leitao, Carol A Aghajanian, Alexia Iasonos, Oliver Zivanovic, Dmitriy Zamarin
Adjuvant chemotherapy is recommended for patients with resected high-risk adult granulosa cell tumors (GCT), although strong data to support this are lacking. The objective of this study was to assess the outcomes of GCT patients, with the specific focus on patients that received adjuvant chemotherapy with curative intent (stage I-III), reported in a large national cancer registry. Data from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2013 were used for analysis. Patient and disease characteristics were extracted and analyzed for association with administration of chemotherapy...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29666981/an-early-life-mucosal-insult-temporarily-decreases-acute-oxazolone-induced-inflammation-in-mice
#2
Katja M Bendtsen, Peter Tougaard, Axel K Hansen
Inflammatory priming of immune cells in early life may optimize the response to a subsequent inflammatory challenge later in life. To prime the immune cells in the gut in vivo through a short inflammatory insult, we administered a low dose of dextran sulfate sodium (DSS) to 5-weeks-old BALB/c mice in the drinking water. We hypothesized that DSS-primed mice would show decreased inflammation and difference in immunological profiling, when subjected to presensitizing and oxazolone-induced colitis by rectal instillation at 9 weeks compared to non-DSS-primed control mice...
April 18, 2018: Inflammation
https://www.readbyqxmd.com/read/29662851/anti-colitic-effect-of-purple-carrot-on-dextran-sulfate-sodium-dss-induced-colitis-in-c57bl-6j-mice
#3
Yeung-Ju Kim, Jaehyun Ju, Jia-Le Song, Suk-Geun Yang, Kun-Young Park
The anti-colitic effect of purple carrot (PC) on 2% dextran sulfate sodium (DSS)-induced colitis in C57BL6/J mice was compared with those of yellow carrot (YC), beet (BT), and red cabbage (RC). Component analysis showed that PC contained cyanidin-3-xyloglucoside, cyanidin-3-xylosyl(sinapoly-glucosyl)galactoside, cyanidin-3-xylosyl(feruloylglucosyl) galactoside, and cyanidin-3- O -(6- O -glycosyl-2- O -xylosylgalactoside). PC diet (5% in AIN 93G diet) strongly reduced DSS-induced colon shortening and inflammatory cell infiltration in mice, followed by RC, BT, and YC diets...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29662438/cannabinoid-receptor-type-1-expression-in-the-developing-avian-retina-morphological-and-functional-correlation-with-the-dopaminergic-system
#4
Luzia da Silva Sampaio, Regina C C Kubrusly, Yolanda P Colli, Priscila P Trindade, Victor T Ribeiro-Resende, Marcelo Einicker-Lamas, Roberto Paes-de-Carvalho, Patricia F Gardino, Fernando G de Mello, Ricardo A De Melo Reis
The avian retina has been used as a model to study signaling by different neuro- and gliotransmitters. It is unclear how dopaminergic and cannabinoid systems are related in the retina. Here we studied the expression of type 1 and 2 cannabinoid receptors (CB1 and CB2 ), as well as monoacylglycerol lipase (MAGL), the enzyme that degrades 2-arachidonoylglycerol (2-AG), during retina development. Our data show that CB1 receptor is highly expressed from embryonic day 5 (E5) until post hatched day 7 (PE7), decreasing its levels throughout development...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29661352/effects-of-alpinetin-on-intestinal-barrier-function-inflammation-and-oxidative-stress-in-dextran-sulfate-sodium-induced-ulcerative-colitis-mice
#5
Yue Tan, Changqing Zheng
BACKGROUND: Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata that has demonstrated anti-inflammatory, antibacterial and anti-tumor activities. However, alpinetin has not been widely studied in amelioration of inflammatory bowel disease. The study aimed to investigate the role of alpinetin on intestinal epithelial tight junctions, oxidative stress and Nrf2/HO-1 signaling pathway in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: A total of 40 mice were divided into 5 groups (n = 8/group): control group, DSS group (received 3% DSS), and low, medium and high-dose treatment groups (3% DSS + alpinetin 25, 50 and 100mg/kg)...
April 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29661250/isocitrate-dehydrogenase-1-snail-axis-dysfunction-significantly-correlates-with-breast-cancer-prognosis-and-regulates-cell-invasion-ability
#6
Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger, Kuo-Wang Tsai
BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. METHODS: In this study, the clinical impact of IDH1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay (IHC) of the corresponding tumor-adjacent normal, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) tissues from 309 patients with breast ductal carcinoma...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29656647/tea-polysaccharides-inhibits-colitis-associated-colorectal-cancer-via-interleukin-6-stat3-pathway
#7
Li-Qiao Liu, Mingyue Shen, Shao-Ping Nie, Jie-Lun Hu, Qiang Yu, Deming Gong, Ming-Yong Xie
The interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)-3 signaling pathway regulates survival and proliferation of intestinal epithelial cells, and has profound impact on the tumorigenesis of colitis-associated cancer (CAC). Tea polysaccharides (TPS) is the major nutraceutical component isolated from tea-leaves and is known to possess antioxidant, anti-inflammatory and antitumor bi-oactivities. Here, we investigated the antitumor activities of TPS on CAC using the azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model and IL-6-induced colorectal cancer cell line (CT26), and determined whether TPS exerted its antitumor effects through the IL-6/STAT3 pathway...
April 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29655682/pristimerin-a-naturally-occurring-triterpenoid-attenuates-tumorigenesis-in-experimental-colitis-associated-colon-cancer
#8
Ju-Hyung Park, Jin-Kyung Kim
BACKGROUND: Pristimerin is a quinonemethide triterpenoid with anti-cancer, anti-angiogenic, anti-inflammatory and anti-protozoal activity. However, the therapeutic role of pristimerin in colitis-associated colorectal carcinogenesis is unknown. PURPOSE: We sought to examine the therapeutic effects of pristimerin on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS). The goal was to identify the potential mechanism of action underlying the pharmacological activity of pristimerin...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29653414/new-insights-on-the-modulatory-roles-of-metformin-or-alpha-lipoic-acid-versus-their-combination-in-dextran-sulfate-sodium-induced-chronic-colitis-in-rats
#9
Fatma S Samman, Samah M Elaidy, Soha S Essawy, Mohammad S Hassan
BACKGROUND: Dextran sulfate sodium (DSS)-induced colitis is the most widely used model that resembles ulcerative colitis (UC) in human with challenging chronic mechanistic oxidative stress-inflammatory/immunological cascades. In models of acute colitis, reduction of oxidative stress and inflammatory burdens beside manipulation of many transcriptional factors were achieved by metformin or alpha-lipoic acid (α-LA). Currently, in vivo DSS-induced chronic colitis was conducted and the possible therapeutic roles of metformin and/or α-LA were explored...
November 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29651712/prognostic-impact-of-nodal-relapse-in-definitive-prostate-only-irradiation
#10
Mauro Loi, Luca Incrocci, Isacco Desideri, Pierluigi Bonomo, Beatrice Detti, Gabriele Simontacchi, Daniela Greto, Emanuela Olmetto, Giulio Francolini, Icro Meattini, Lorenzo Livi
BACKGROUND: Whole pelvic irradiation in prostate cancer patients might prevent metastatic spread of cancer cells through lymphatic drainages in patients eligible for definitive radiotherapy, but its use has declined in the last decades in favor of prostate-only irradiation (POI). The aim of our study is to assess the incidence of pelvic lymph nodal relapse and outcome in prostate cancer patients receiving POI. MATERIALS AND METHODS: Data from 207 consecutive patients were collected...
April 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29651648/body-mass-index-and-mortality-in-patients-with-gastric-cancer-a-large-cohort-study
#11
Jung Hwan Lee, Boram Park, Jungnam Joo, Myeong-Cherl Kook, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Soo-Jeong Cho
BACKGROUND: The effects of obesity on prognosis in gastric cancer are controversial. AIMS: To evaluate the association between body mass index (BMI) and mortality in patients with gastric cancer. METHODS: A single-institution cohort of 7765 patients with gastric cancer undergoing curative gastrectomy between October 2000 and June 2016 was categorized into six groups based on BMI: underweight (< 18.5 kg/m2 ), normal (18.5 to < 23 kg/m2 ), overweight (23 to < 25 kg/m2 ), mildly obese (25 to < 28 kg/m2 ), moderately obese (28 to < 30 kg/m2 ), and severely obese (≥ 30 kg/m2 )...
April 12, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29629345/comparative-effects-of-curcumin-and-tetrahydrocurcumin-on-dextran-sulfate-sodium-induced-colitis-and-inflammatory-signaling-in-mice
#12
Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh
Background: Curcumin, a yellow ingredient of turmeric ( Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629026/effect-of-vitamin-c-on-azoxymethane-aom-dextran-sulfate-sodium-dss-induced-colitis-associated-early-colon-cancer-in-mice
#13
Hee-Jin Jeon, Yiseul Yeom, Yoo-Sun Kim, Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Moon Jea Woo, Yuri Kim
BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29627040/insulin-resistance-and-cognitive-test-performance-in-elderly-adults-national-health-and-nutrition-examination-survey-nhanes
#14
Ayesha Z Sherzai, Magda Shaheen, Jeffrey J Yu, Konrad Talbot, Dean Sherzai
OBJECTIVES: To examine the relationship between homeostatic model of insulin resistance (HOMA-IR) and cognitive test performance among population≥60years in a national database. HYPOTHESIS: Higher insulin resistance is associated with lower cognitive test performance score in the population≥60years. PARTICIPANTS: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2001-2002. MEASUREMENTS: Cognitive test performance was measured by the Digit Symbol Substitution (DSS) exercise score...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29626308/patterns-of-treatment-failure-in-patients-with-sinonasal-mucosal-melanoma
#15
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites. OBJECTIVE: The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure. METHODS: This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29625728/long-term-changes-in-depressive-symptoms-and-estimated-cardiorespiratory-fitness-and-risk-of-all-cause-mortality-the-nord-tr%C3%A3-ndelag-health-study
#16
Trude Carlsen, Øyvind Salvesen, Xuemei Sui, Carl J Lavie, Steven N Blair, Ulrik Wisløff, Linda Ernstsen
OBJECTIVE: To assess the independent and combined associations of long-term changes in depressive symptoms (DSs) and estimated cardiorespiratory fitness (eCRF) with all-cause mortality. PARTICIPANTS AND METHODS: This is a longitudinal cohort study of 15,217 middle-aged and older individuals attending both the second (from August 15, 1995, through June 18, 1997) and third (from October 3, 2006, through June 25, 2008) health surveys of the Nord-Trøndelag Health Study, Norway, and followed until December 31, 2014...
March 24, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29625079/dpd-functional-tests-in-plasma-fresh-saliva-and-dried-saliva-samples-as-predictors-of-5-fluorouracil-exposure-and-occurrence-of-drug-related-severe-toxicity
#17
Olavo Vicente Neto, Suziane Raymundo, Maria Alice Franzoi, Andiara do Carmo Artmann, Mariane Tegner, Victoria Vendramini Müller, Roberta Zilles Hahn, Gustavo Vasconcelos Alves, Gilberto Schwartsmann, Rafael Linden, Marina Venzon Antunes
OBJECTIVE: to evaluate plasma and salivary uracil (U) to dihydrouracil (UH2) ratios as tools for predicting 5-fluorouracil systemic exposure and drug-related severe toxicity, and clinically validate the use of dried saliva spots (DSS) as an alternative sampling strategy for dihydropyrimidine dehydrogenase (DPD) deficiency assessment. METHODS: Pre-chemotherapy plasma, fresh saliva and DSS samples were obtained from gastrointestinal patients (N = 40) for measurement of endogenous U and UH2 concentrations by LC-MS/MS...
April 3, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29622848/the-hdac-inhibitor-saha-prevents-colonic-inflammation-by-suppressing-pro-inflammatory-cytokines-and-chemokines-in-dss-induced-colitis
#18
Mohmand Noor Ali, Narantsog Choijookhuu, Hideaki Takagi, Naparee Srisowanna, Mai Nguyen Nhat Huynh, Yuya Yamaguchi, Phyu Synn Oo, Myat Tin Htwe Kyaw, Katsuaki Sato, Ryoji Yamaguchi, Yoshitaka Hishikawa
Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that is caused by multiple factors, including dysfunction of the immune system and genetic and epigenetic alterations. Aberrant epigenetic regulation, especially histone acetylation, was found in biopsies from IBD patients and mouse models of colitis, suggesting that an epigenetic treatment approach may be useful for IBD therapy. Therefore, we investigated the effects of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), in a mouse model of dextran sulfate sodium (DSS)-induced colitis...
February 27, 2018: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/29621481/in-inflamed-intestinal-tissues-and-epithelial-cells-interleukin-22-signaling-increases-expression-of-h19-long-noncoding-rna-which-promotes-mucosal-regeneration
#19
Hua Geng, Heng-Fu Bu, Fangyi Liu, Longtao Wu, Karl Pfeifer, Pauline M Chou, Xiao Wang, Jiaren Sun, Lu Lu, Ashutosh Pandey, Marisa S Bartolomei, Isabelle G De Plaen, Peng Wang, Jindan Yu, Jiaming Qian, Xiao-Di Tan
BACKGROUND & AIMS: Inflammation affects regeneration of the intestinal epithelia; long non-coding RNAs (lncRNAs) regulate cell functions such as proliferation, differentiation, and migration. We investigated the mechanisms by which the lncRNA H19, imprinted maternally expressed transcript (H19) regulates regeneration of intestinal epithelium using cell cultures and mouse models of inflammation. METHODS: We performed RNA-seq transcriptome analyses of intestinal tissues from mice with LPS-induced sepsis to identify lncRNAs associated with inflammation; findings were confirmed by quantitative real-time PCR and in situ hybridization analyses of intestinal tissues from mice with sepsis or dextran sulfate sodium (DSS)-induced mucosal wound healing and patients with ulcerative colitis, compared to healthy individuals (controls)...
April 2, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29620964/prognostic-implication-of-n1b-classification-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-system-of-differentiated-thyroid-cancer
#20
Mijin Kim, Min Ji Jeon, Hye-Seon Oh, Suyeon Park, Dong Eun Song, Tae-Yon Sung, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, Young Kee Shong, Yu-Mi Lee, Won Gu Kim
BACKGROUND: Regional lymph node metastases (LNM) have prognostic significance in differentiated thyroid cancer (DTC). However, there was no distinction between N1a and N1b in the final staging classification in the eighth edition of the tumor-node-metastasis (TNM) staging system. This study aimed to evaluate the prognostic implication of N1b classification for predicting disease-specific survival (DSS) in DTC patients with stage I/II disease. METHODS: A total of 3089 patients with stage I/II DTC who underwent thyroid surgery between 1996 and 2005 were included...
April 2018: Thyroid: Official Journal of the American Thyroid Association
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