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https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#1
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29907869/bves-is-required-for-maintenance-of-colonic-epithelial-integrity-in-experimental-colitis-by-modifying-intestinal-permeability
#2
Yash A Choksi, Vishruth K Reddy, Kshipra Singh, Caitlyn W Barrett, Sarah P Short, Bobak Parang, Cody E Keating, Joshua J Thompson, Thomas G Verriere, Rachel E Brown, M Blanca Piazuelo, David M Bader, M Kay Washington, Mukul K Mittal, Thomas Brand, Alain P Gobert, Lori A Coburn, Keith T Wilson, Christopher S Williams
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. There have been no in vivo studies investigating the role of BVES in colitis. We hypothesized that BVES is critical for maintaining colonic epithelial integrity. At baseline, Bves -/- mouse colons demonstrate increased crypt height, elevated proliferation, decreased apoptosis, altered intestinal lineage allocation, and dysregulation of tight junctions with functional deficits in permeability and altered intestinal immunity...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907361/mesenchymal-stem-cell-expression-of-interleukin-35-protects-against-ulcerative-colitis-by-suppressing-mucosal-immune-responses
#3
Yongjia Yan, Na Zhao, Xianghui He, Hao Guo, Zhixiang Zhang, Tong Liu
BACKGROUND: Interleukin-35 (IL-35) has recently been identified as an immunosuppressive cytokine that has been used as a potential therapy for chronic inflammatory and autoimmune diseases. However, there remains a paucity of data regarding its potential benefits after integration into mesenchymal stem cells (MSCs). METHODS: We used a dextran sulfate sodium (DSS)-induced colitis mice model and treated them with IL-35-MSCs, MSCs or saline. The body weight was recorded daily and inflammatory processes were determined...
June 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29907343/dietary-supplement-use-in-a-large-representative-sample-of-the-us-armed-forces
#4
Joseph J Knapik, Krista G Austin, Emily K Farina, Harris R Lieberman
BACKGROUND: Dietary supplement (DS) use is prevalent among the US Armed Forces personnel, but representative cross-service comparisons and characteristics of personnel using DSs are limited. OBJECTIVE: Examine DS use and characteristics associated with use in a representative sample of US Armed Forces personnel (Army, Navy, Air Force, Marine Corps, and Coast Guard) using data from the 2011 Department of Defense Survey of Health-Related Behaviors. DESIGN AND PARTICIPANTS: A stratified random sample of service members (SMs) was contacted and asked to complete a questionnaire assessing personal characteristics and DS use...
June 12, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29906615/studying-a-rare-disease-using-multi-institutional-research-collaborations-vs-big-data-where-lies-the-truth
#5
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel
BACKGROUND: Multi-institutional collaborations provide granularity lacking in epidemiologic datasets to enable in-depth study of rare diseases. For pts with superficial, high-grade soft tissue sarcomas (STS) of the trunk/extremity, the value of radiation therapy (RT) is not clear. We aimed to utilize the 7-institution US-Sarcoma-Collaborative (USSC) and the National Cancer Database (NCDB) to investigate this issue. STUDY DESIGN: All adult pts with superficial truncal/extremity high-grade STS who underwent primary curative-intent resection from 2000-2016 at USSC institutions or were included in the NCDB from 2004-2013 were analyzed...
June 12, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29904348/berberine-regulates-treg-th17-balance-to-treat-ulcerative-colitis-through-modulating-the-gut-microbiota-in-the-colon
#6
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29904247/stage-iii-should-be-subclassified-into-stage-iiia-and-iiib-in-the-american-joint-committee-on-cancer-8-th-edition-staging-system-for-pancreatic-cancer
#7
Hai-Feng Yu, Bing-Qing Zhao, Yong-Cheng Li, Jun Fu, Wei Jiang, Rong-Wei Xu, Hao-Chang Yang, Xiao-Jun Zhang
AIM: To ascertain the prognostic role of the T4 and N2 category in stage III pancreatic cancer according to the 8th edition of the American Joint Committee on Cancer (AJCC) classification. METHODS: Patients were collected from the Surveillance Epidemiology and End Results (SEER) database (2004-2013) and were divided into three groups: T(1-3)N2, T4N(0-1), and T4N2. Overall survival (OS) and disease-specific survival (DSS) of patients were evaluated by the Kaplan-Meier method...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29903475/computerized-decision-support-for-beneficial-home-based-exercise-rehabilitation-in-patients-with-cardiovascular-disease
#8
Andreas Triantafyllidis, Dimitris Filos, Roselien Buys, Jomme Claes, Véronique Cornelissen, Evangelia Kouidi, Anargyros Chatzitofis, Dimitris Zarpalas, Petros Daras, Deirdre Walsh, Catherine Woods, Kieran Moran, Nicos Maglaveras, Ioanna Chouvarda
BACKGROUND: Exercise-based rehabilitation plays a key role in improving the health and quality of life of patients with Cardiovascular Disease (CVD). Home-based computer-assisted rehabilitation programs have the potential to facilitate and support physical activity interventions and improve health outcomes. OBJECTIVES: We present the development and evaluation of a computerized Decision Support System (DSS) for unsupervised exercise rehabilitation at home, aiming to show the feasibility and potential of such systems toward maximizing the benefits of rehabilitation programs...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29902912/-6-gingerol-modulates-spermatotoxicity-associated-with-ulcerative-colitis-and-benzo-a-pyrene-exposure-in-balb-c-mice
#9
Babajide O Ajayi, Isaac A Adedara, Olumide S Ajani, Matthew O Oyeyemi, Ebenezer O Farombi
BACKGROUND: The deterioration of male reproductive health may represent an outcome of an active disease and environmental factors. The present study investigated the modulatory role of [6]-gingerol in spermatotoxicity resulting from colitis and benzo[a]pyrene (B[a]P), an environmental and food-borne pollutant. METHODS: Group I (control) mice received corn oil alone, while group II ([6]-gingerol alone) mice orally received [6]-gingerol alone at 100 mg/kg body weight...
June 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29901822/malt1-blocks-il-1%C3%AE-production-by-macrophages-in-vitro-and-limits-dextran-sodium-sulfate-induced-intestinal-inflammation-in-vivo
#10
Mahdis Monajemi, Yvonne C F Pang, Saelin Bjornson, Susan C Menzies, Nico van Rooijen, Laura M Sly
This study tested the hypothesis that Malt1 deficiency in macrophages contributes to dextran sodium sulfate (DSS)-induced intestinal inflammation in Malt1-deficient mice. In people, combined immunodeficiency caused by a homozygous mutation in the MALT1 gene is associated with increased susceptibility to bacterial infections and chronic inflammation, including severe inflammation along the gastrointestinal tract. The consequences of Malt1 deficiency have largely been attributed to its role in lymphocytes, but Malt1 is also expressed in macrophages, where it is activated downstream of TLR4 and dectin-1...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29901817/nicotine-treatment-ameliorates-dss-induced-colitis-by-suppressing-madcam-1-expression-and-leukocyte-recruitment
#11
Koji Maruta, Chikako Watanabe, Hideaki Hozumi, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Yoshikiyo Okada, Kazuhiko Shirakabe, Masaaki Higashiyama, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Toshiaki Ishizuka, Soichiro Miura, Ryota Hokari
The enhanced recruitment of leukocytes to the inflamed colon is a key feature of ulcerative colitis (UC). The gut-specific adhesion molecules involved in leukocyte recruitment have emerged as recent therapeutic targets. Nicotine absorbed from smoking has been reported to work protectively in UC patients. Our hypothesis is that nicotine may suppress the aberrant leukocyte recruitment and colonic inflammation via the suppression of the overexpressed gut-specific adhesion molecules in the inflamed colon. To test this hypothesis, the severity of colitis and the degree of leukocyte recruitment induced by gut-specific adhesion molecules were assessed in dextran sulfate sodium (DSS) colitis mice (C57BL/6J mice treated with 3% DSS) with or without nicotine treatment...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29901779/dro1-ccdc80-inactivation-promotes-aom-dss-induced-colorectal-carcinogenesis-and-aggravates-colitis-by-dss-in-mice
#12
Jessica I Grill, Jens Neumann, Andrea Ofner, Maximilian K Marschall, Heike Zierahn, Andreas Herbst, Eckhard Wolf, Frank T Kolligs
Colorectal carcinogenesis is a progressive multistep process involving the sequential accumulation of genetic alterations in tumor suppressor genes and oncogenes. Down regulated by oncogenes 1 (Dro1/Ccdc80) has been shown to be a potent tumor suppressor of colorectal carcinogenesis in the genetic ApcMin/+ mouse model. In ApcMin/+ mice loss of DRO1 strongly increases colonic tumor multiplicity and leads to the regular formation of adenocarcinoma in the colon. To investigate DRO1`s role in chemically induced as well as inflammation-associated colorectal carcinogenesis the effect of Dro1 inactivation was studied in mice subjected to the carcinogen azoxymethane (AOM) and upon combined treatment with AOM and the proinflammatory agent dextran sodium sulfate (DSS), respectively...
June 13, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29901086/exclusive-enteral-nutrition-protects-against-inflammatory-bowel-disease-by-inhibiting-nf%C3%A2-%C3%AE%C2%BAb-activation-through-regulation-of-the-p38-msk1-pathway
#13
Ting Yu, Qian Yu, Xiaotian Chen, Lixing Zhou, Yuming Wang, Chenggong Yu
Although enteral nutrition therapy for inflammatory bowel disease has been confirmed to be an effective treatment method, the exact mechanism responsible for the effects of enteral nutrition remains unclear. The aim of the present study was to investigate the protective effect of exclusive enteral nutrition (EEN) against colitis, and to elucidate the potential mechanisms by inhibiting p65 activation via regulating the p38/mitogen‑ and stress‑activated protein kinase‑1 (MSK1) pathway. Experiments were performed by establishing dextran sulfate sodium (DSS)‑mice colitis and picrylsulfonic acid solution (TNBS)‑induced rat colitis, and the results demonstrated that EEN treatment attenuated body weight loss, colon length shortening and colonic pathological damage caused by colitis...
June 4, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29900414/development-and-validation-of-the-dutch-stroke-score-for-predicting-disability-and-functional-outcome-after-ischemic-stroke-a-tool-to-support-efficient-discharge-planning
#14
Inger R de Ridder, Simone A Dijkland, Maaike Scheele, Heleen M den Hertog, Maaike Dirks, Willeke F Westendorp, Paul J Nederkoorn, Diederik van de Beek, Gerard M Ribbers, Ewout W Steyerberg, Hester F Lingsma, Diederik Wj Dippel
Introduction: We aimed to develop and validate a prognostic score for disability at discharge and functional outcome at three months in patients with acute ischemic stroke based on clinical information available on admission. Patients and methods: The Dutch Stroke Score (DSS) was developed in 1227 patients with ischemic stroke included in the Paracetamol (Acetaminophen) In Stroke study. Predictors for Barthel Index (BI) at discharge ('DSS-discharge') and modified Rankin Scale (mRS) at three months ('DSS-3 months') were identified in multivariable ordinal regression...
June 2018: European stroke journal
https://www.readbyqxmd.com/read/29899832/subclassification-survival-prediction-and-drug-target-analyses-of-chemotherapy-na%C3%A3-ve-muscle-invasive-bladder-cancer-with-a-molecular-screening
#15
Sebastien Rinaldetti, Eugen Rempel, Thomas Stefan Worst, Markus Eckstein, Annette Steidler, Cleo Aaron Weiss, Christian Bolenz, Arndt Hartmann, Philipp Erben
Background: Transcriptome expression studies identified distinct muscle invasive bladder cancer (MIBC) subtypes closely related with breast cancer subclasses. Here we developed a sensitive quantification method for MIBC subclassification (luminal, basal, p53-like). In addition, the subtype specific expression of drug targets has been investigated. Methods: Absolute quantification (nCounter) of a 64-gene panel was performed on MIBC patients (n=47) treated exclusively with radical cystectomy (RC)...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29897487/dietary-red-raspberry-reduces-colorectal-inflammation-and-carcinogenic-risk-in-mice-with-dextran-sulfate-sodium-induced-colitis
#16
Shima Bibi, Min Du, Mei-Jun Zhu
Background: Ulcerative colitis causes recurring intestinal mucosal injury and sustained inflammation, increasing the likelihood of colorectal cancer (CRC) development. Dietary red raspberry (RB) is a rich source of phytonutrients known to have anti-inflammatory activity; however, the role of RB on CRC prevention in chronic colitis has not been examined. Objective: This study examined the effects of dietary RB supplementation on inflammation, epithelium repair, and oncogenic signaling in dextran sulfate sodium (DSS)-induced chronic colitis in mice...
April 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29897011/using-the-ata-risk-stratification-system-to-refine-and-individualize-the-ajcc-8th-edition-disease-specific-survival-estimates-in-differentiated-thyroid-cancer
#17
Sana A Ghaznavi, Ian Ganly, Ashok R Shaha, Crystal L English, Jonathan Wills, Robert Michael Tuttle
Background The 8th edition AJCC staging system has reclassified up to one third of differentiated thyroid cancer patients into one of the younger prognostic stage groups (<55 years of age at diagnosis, stage I or stage II). This reclassification widens the spectrum of disease in these lower stages without significantly impacting overall disease specific survival (DSS) for the entire stage group. However, the optimistic DSS estimates in the < 55 year old stage groups may not accurately reflect the prognosis of individual patients with American Thyroid Association (ATA) high risk features...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29897005/decreasing-disease-specific-mortality-of-differentiated-thyroid-cancer-in-korea-a-multicenter-cohort-study
#18
MinJi Jeon, Hee Kyung Kim, Eun Heui Kim, Eun Sook Kim, Hyon-Seung Yi, Tae Yong Kim, Ho Cheol Kang, YoungKee Shong, Won Bae Kim, Bo Hyun Kim, Won Gu Kim
BACKGROUND: Recent studies have reported improved survival in patients with thyroid cancer. We evaluated the changes in disease-specific survival (DSS) of patients with differentiated thyroid cancer (DTC) in association with clinicopathological characteristics from 1996 to 2005 in Korea. METHODS: This was a retrospective, multi-center cohort study. A total of 4,398 DTC patients were included and classified according to the year of initial surgery: 1996-2000 (Period 1), 2001-2003 (Period 2), and 2004-2005 (Period 3)...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29896300/pias3-mediated-feedback-loops-promote-chronic-colitis-associated-malignant-transformation
#19
Junting Ma, Yaping Yang, Yong Fu, Feilong Guo, Xiaoyi Zhang, Shuke Xiao, Weiming Zhu, Zhen Huang, Junfeng Zhang, Jiangning Chen
Rationale: Colitis-associated colorectal cancer (CAC) usually exhibits an accelerated disease progression, an increased resistance to therapeutic drugs and a higher mortality rate than sporadic colorectal cancer (CRC). PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family; however, little is known about the expression and biological functions of PIAS3 in CAC. The aim of our study was to investigate the biological mechanisms of PIAS3 in CAC. Methods: PIAS3 expression was examined in colon tissues of CAC/CRC patients and azoxymethane-dextran sulfate sodium (AOM-DSS)-induced mice...
2018: Theranostics
https://www.readbyqxmd.com/read/29896196/persistent-salmonella-enterica-serovar-typhimurium-infection-increases-the-susceptibility-of-mice-to-develop-intestinal-inflammation
#20
Bárbara M Schultz, Geraldyne A Salazar, Carolina A Paduro, Catalina Pardo-Roa, Daniela P Pizarro, Francisco J Salazar-Echegarai, Javiera Torres, Claudia A Riedel, Alexis M Kalergis, Manuel M Álvarez-Lobos, Susan M Bueno
Chronic intestinal inflammations are triggered by genetic and environmental components. However, it remains unclear how specific changes in the microbiota, host immunity, or pathogen exposure could promote the onset and exacerbation of these diseases. Here, we evaluated whether Salmonella enterica serovar Typhimurium ( S . Typhimurium) infection increases the susceptibility to develop intestinal inflammation in mice. Two mouse models were used to evaluate the impact of S . Typhimurium infection: the chemical induction of colitis by dextran sulfate sodium (DSS) and interleukin (IL)-10-/- mice, which develop spontaneous intestinal inflammation...
2018: Frontiers in Immunology
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