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https://www.readbyqxmd.com/read/28636557/surgical-management-for-follicular-variant-of-papillary-thyroid-carcinoma
#1
Jianing Tang, Deguang Kong, Lupin Bu, Gaosong Wu
BACKGROUND AND AIMS: For most patients with follicular variant of papillary thyroid carcinoma (FVPTC), surgery is required, while the surgical management remains controversial. We aim to further understanding of treatment of FVPTC and to determine whether specific features could be identified for the decision of surgical strategy. MATERIALS AND METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program database during 2003 and 2013...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28635571/comparison-of-the-7th-and-8th-editions-of-the-ajcc-uicc-tnm-staging-system-for-differentiated-thyroid-cancer
#2
Mijin Kim, Won Gu Kim, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Dong Eun Song, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Tae-Yon Sung, MinJi Jeon
OBJECTIVE: To evaluate the efficacy and prognostic validity for disease-specific survival (DSS) of the 8th edition American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system (TNM-8) compared with the 7th edition (TNM-7) in patients with differentiated thyroid carcinoma (DTC). METHODS: The 7th and 8th editions of the TNM staging system were applied to 1613 DTC patients who underwent thyroid surgery between 1996 and 2003...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28634361/uridine-ameliorates-dextran-sulfate-sodium-dss-induced-colitis-in-mice
#3
Manish Kumar Jeengar, Dinesh Thummuri, Mattias Magnusson, V G M Naidu, Srinivas Uppugunduri
Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation. The aim of the present study was to investigate the potential protective effect of intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation of 3 doses of uridine 1 mg/Kg (lower dose), 5 mg/Kg (medium dose), and 10 mg/Kg (higher dose) in saline was performed daily...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631440/recognition-cascade-and-metabolite-transfer-in-a-marine-bacteria-phytoplankton-model-system
#4
Bryndan P Durham, Stephen P Dearth, Shalabh Sharma, Shady A Amin, Christa B Smith, Shawn R Campagna, E Virginia Armbrust, Mary Ann Moran
The trophic linkage between marine bacteria and phytoplankton in the surface ocean is a key step in the global carbon cycle, with almost half of marine primary production transformed by heterotrophic bacterioplankton within hours to weeks of fixation. Early studies conceptualized this link as the passive addition and removal of organic compounds from a shared seawater reservoir. Here we analyzed transcript and intracellular metabolite patterns in a two-member model system and found that the presence of a heterotrophic bacterium induced a potential recognition cascade in a marine phytoplankton species that parallels better-understood vascular plant response systems...
June 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28631049/novel-probiotics-isolated-from-a-japanese-traditional-fermented-food-funazushi-attenuates-dss-induced-colitis-by-increasing-the-induction-of-high-integrin-%C3%AE-v-%C3%AE-8-expressing-dendritic-cells
#5
Yoshikiyo Okada, Yoshikazu Tsuzuki, Takajo Takeshi, Hirotaka Furuhashi, Masaaki Higashiyama, Chikako Watanabe, Kazuhiko Shirakabe, Chie Kurihara, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari
BACKGROUND: We isolated two novel probiotics strains (s193 and s292) from Funazushi, which is a traditional Japanese fermented food, and evaluated its effects on DSS-induced colitis to determine the possible underlying mechanisms. METHODS: A single colony from homogenized Funazushi was isolated by its ability to suppress TNF-α in RAW 264.7. Effect of probiotics on colonic inflammation induced by DSS was evaluated. Effect of probiotics on Treg induction by CD11c(+) dendritic cells (DCs) of MLNs were analyzed...
June 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28630868/serum-dried-samples-to-detect-dengue-antibodies-a-field-study
#6
Angelica Maldonado-Rodríguez, Othon Rojas-Montes, Guillermo Vazquez-Rosales, Adolfo Chavez-Negrete, Magdalena Rojas-Uribe, Araceli Posadas-Mondragon, Leopoldo Aguilar-Faisal, Ana Maria Cevallos, Beatriz Xoconostle-Cazares, Rosalia Lira
BACKGROUND: Dried blood and serum samples are useful resources for detecting antiviral antibodies. The conditions for elution of the sample need to be optimized for each disease. Dengue is a widespread disease in Mexico which requires continuous surveillance. In this study, we standardized and validated a protocol for the specific detection of dengue antibodies from dried serum spots (DSSs). METHODS: Paired serum and DSS samples from 66 suspected cases of dengue were collected in a clinic in Veracruz, Mexico...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28629174/using-coexpression-protein-interaction-network-analysis-to-identify-mechanisms-of-danshensu-affecting-patients-with-coronary-heart-disease
#7
Mengqi Huo, Zhixin Wang, Dongxue Wu, Yanling Zhang, Yanjiang Qiao
Salvia miltiorrhiza, known as Danshen, has attracted worldwide interest for its substantial effects on coronary heart disease (CHD). Danshensu (DSS) is one of the main active ingredients of Danshen on CHD. Although it has been proven to have a good clinical effect on CHD, the action mechanisms remain elusive. In the current study, a coexpression network-based approach was used to illustrate the beneficial properties of DSS in the context of CHD. By integrating the gene expression profile data and protein-protein interactions (PPIs) data, two coexpression protein interaction networks (CePIN) in a CHD state (CHD CePIN) and a non-CHD state (non-CHD CePIN) were generated...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28624320/prognostic-value-of-the-vhl-hif-1%C3%AE-and-vegf-signaling-pathway-and-associated-mapk-erk1-2-and-erk5-pathways-in-clear-cell-renal-cell-carcinoma-a-long-term-study
#8
Antonio S Salinas-Sánchez, Leticia Serrano-Oviedo, Syongh Y Nam-Cha, Olga Roche-Losada, Ricardo Sánchez-Prieto, José M Giménez-Bachs
BACKGROUND: The prognostic value of molecular markers in renal cell carcinoma has been investigated in several studies. Although their value is still not confirmed, various proteins are important. We describe the effect on long-term survival of the status of the von Hippel-Lindau (VHL) hypoxia-inducible factor 1-α (HIF1-α) signaling pathway as well as associated mitogen-activated protein kinase (extracellular signal-regulated kinase [ERK]1/2 and ERK5). PATIENTS AND METHODS: A prospective, longitudinal cohort study was conducted with 50 patients diagnosed with clear-cell renal cell carcinoma to analyze VHL mutations and hypermethylation as well as VHL, HIF1-α, vascular endothelial growth factor (VEGF), ERK1/2, and ERK5 protein expression...
May 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#9
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28621690/ratio-of-positive-lymph-nodes-the-prognostic-value-in-stage-iv-thyroid-cancer
#10
Tingyin Jiang, Chunling Huang, Yuan Xu, Yingrui Su, Guanjie Zhang, Long Xie, Liqun Huang, Shuchun You, Jinshun Zha
To assess the prognostic value of lymph node ratio (LNR) in patients with stage IV thyroid cancer based on the Surveillance, Epidemiology, and End Results (SEER) database. A total of 4,940 eligible patients were included for the analysis. Kaplan-Meier survival analysis and Cox proportional hazard regression were used to reveal the effect of LNR on overall survival (OS) and disease specific survival (DSS). The optimal cut-off value of LNR for predicting OS and DSS was determined by the time-dependent Receiver Operating Characteristic analysis...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619710/heme-oxygenase-1-production-by-intestinal-cx3cr1-macrophages-helps-to-resolve-inflammation-and-prevents-carcinogenesis
#11
Giulia Marelli, Marco Erreni, Achille Anselmo, Valentina Taverniti, Simone Guglielmetti, Alberto Mantovani, Paola Allavena
CX3CR1(+) macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL-10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammation despite high production of IL-10 and have increased colitis and adenomatous polyps in chemical and genetic models of colon carcinogenesis. Mechanistically, CX3CL1-mediated engagement of the CX3CR1 receptor induced upregulation of hemoxygenase-1 (HMOX-1), an antioxidant and anti-inflammatory enzyme...
June 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28618417/cholesterol-enhances-colorectal-cancer-progression-via-ros-elevation-and-mapk-signaling-pathway-activation
#12
Caihua Wang, Peiwei Li, Junmei Xuan, Chunpeng Zhu, Jingjing Liu, Lizhen Shan, Qin Du, Yuezhong Ren, Jun Ye
BACKGROUND/AIMS: Elevated serum cholesterol levels were linked to a higher risk of colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC metastasis has not been widely studied. METHODS: CRC patients were enrolled to evaluate the association between low-density lipoprotein cholesterol (LDL) and CRC metastases, and LDL receptor (LDLR) level of the CRC tissue was assessed by immunohistochemistry. The effects of LDL on cell proliferation, migration and stemness were assessed in CRC cells in vitro, and the effects of high fat diet (HFD) on tumor growth and intestinal tumorigenicity were investigated in vivo...
June 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28615528/genistein-improves-inflammatory-response-and-colonic-function-through-nf-%C3%AE%C2%BAb-signal-in-dss-induced-colonic-injury
#13
Rui Zhang, Jian Xu, Jian Zhao, Yuzhe Chen
This study aimed to investigate the protective potential of genistein in dextran sulfate sodium (DSS)-induced colonic injury in vitro and in vivo models. The results showed that DSS exposure caused growth suppression, colonic injury, inflammation, and barrier dysfunction in mice. Dietary genistein alleviated DSS-caused colonic injury via reducing colonic weight, rectal bleeding, and diarrhea ratio. Meanwhile, genistein reduced colonic inflammatory response via downregulating cytokines expression and improved colonic permeability and barrier in DSS-challenged mice...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28614718/sirt5-desuccinylates-and-activates-pyruvate-kinase-m2-to-block-macrophage-il-1%C3%AE-production-and-to-prevent-dss-induced-colitis-in-mice
#14
Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, Dan Ye, Yi Wang, Ying Xu, Lisha Zhou, Yiwei Chu, Cuiping Zhang, Xue Qin, Pengyuan Yang, Hongxiu Yu
LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant. Here, we show that PKM2 is a physiological substrate of SIRT5 and that SIRT5-regulated hypersuccinylation inhibits the pyruvate kinase activity of PKM2 by promoting its tetramer-to-dimer transition. Moreover, a succinylation-mimetic PKM2 K311E mutation promotes nuclear accumulation and increases protein kinase activity. Furthermore, we show that SIRT5-dependent succinylation promotes PKM2 entry into nucleus, where a complex of PKM2-HIF1α is formed at the promoter of IL-1β gene in LPS-stimulated macrophages...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28614717/microbiota-normalization-reveals-that-canonical-caspase-1-activation-exacerbates-chemically-induced-intestinal-inflammation
#15
Adrian J Błażejewski, Sophie Thiemann, Alexander Schenk, Marina C Pils, Eric J C Gálvez, Urmi Roy, Ulrike Heise, Marcel R de Zoete, Richard A Flavell, Till Strowig
Inflammasomes play a central role in regulating intestinal barrier function and immunity during steady state and disease. Because the discoveries of a passenger mutation and a colitogenic microbiota in the widely used caspase-1-deficient mouse strain have cast doubt on previously identified direct functions of caspase-1, we reassessed the role of caspase-1 in the intestine. To this end, we generated Casp1(-/-) and Casp11(-/-) mice and rederived them into an enhanced barrier facility to standardize the microbiota...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28612239/dengue-hemorrhagic-fever-a-state-of-the-art-review-focused-in-pulmonary-involvement
#16
REVIEW
Renata Rocha de Almeida, Bernardo Paim, Solange Artimos de Oliveira, Arthur Soares Souza, Antônio Carlos Portugal Gomes, Dante Luiz Escuissato, Gláucia Zanetti, Edson Marchiori
Dengue fever is an arboviral disease transmitted to humans through the bites of infected female Aedes mosquitoes. Dengue virus is a member of the Flaviviridae family, and human infection can be caused by any of the four antigenically distinct serotypes (DENV 1-4). The infection has become recognized as the most important and prevalent arboviral disease in humans, endemic in almost 100 countries worldwide. Nearly 3 billion people live in areas with transmission risk. Autochthonous transmission of the virus in previously disease-free areas, increased incidence in endemic areas, and epidemic resurgence in controlled regions could increase the risk of contracting more severe forms of the disease, such as dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS)...
June 13, 2017: Lung
https://www.readbyqxmd.com/read/28608623/guar-gum-fiber-increases-suppressor-of-cytokine-signaling-1-expression-via-toll-like-receptor-2-and-dectin-1-pathways-regulating-inflammatory-response-in-small-intestinal-epithelial-cells
#17
Tran Van Hung, Takuya Suzuki
SCOPE: Direct regulation of intestinal inflammation by intact dietary fibers is still unclear. Here, the anti-inflammatory regulation by intact guar gum (GG) was investigated using mice and human intestinal Caco-2 cells. METHODS AND RESULTS: Administration of dextran sodium sulfate (DSS) increased myeloperoxidase activity and CXC motif chemokine ligand2 (an IL-8 homologue) expression in the small intestines of mice, while supplemental GG reduced these increases...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28607633/pterostilbene-4-%C3%AE-glucoside-protects-against-dss-induced-colitis-via-induction-of-tristetraprolin
#18
Yingqing Chen, Jeongmin Park, Yeonsoo Joe, Hyeok-Jun Park, Seung-Joo Jekal, Daisuke Sato, Hiroki Hamada, Hun Taeg Chung
Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3'-untranslated regions of mRNAs. Here, we utilized pterostilbene 4'-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28607594/high-expression-of-aldolase-b-confers-a-poor-prognosis-for-rectal-cancer-patients-receiving-neoadjuvant-chemoradiotherapy
#19
Yu-Feng Tian, Pei-Ling Hsieh, Ching-Yih Lin, Ding-Ping Sun, Ming-Jen Sheu, Ching-Chieh Yang, Li-Ching Lin, Hong-Lin He, Julia Solórzano, Chien-Feng Li, I-Wei Chang
Background : Colorectal cancer is the third most common cancer in both sex worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a documented database of rectal cancer transcriptome (GSE35452) from Gene Expression Omnibus, National Center of Biotechnology Information, we recognized that ALDOB was the most significantly up-regulated transcript among those related to glycolysis (GO: 0006096)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28607413/early-gut-microbiota-intervention-suppresses-dss-induced-inflammatory-responses-by-deactivating-tlr-nlr-signalling-in-pigs
#20
Yi Xiao, Honglin Yan, Hui Diao, Bing Yu, Jun He, Jie Yu, Ping Zheng, Xiangbing Mao, Yuheng Luo, Daiwen Chen
Recent metagenomic studies suggest that innate and adaptive immune phenotypes can be programmed via gut microbiota-host interactions mediated via activation of pattern recognition receptors (PRRs) on host cells. In this study, we used two extremely different pig lines (the Yorkshire and the Tibetan) to test the hypothesis that the transplantation of gut microbiota could transfer certain immunologic characteristics from donor to recipient. The faecal microbiota of these two pig lines was transplanted in healthy commercial hybrid newborn piglets to establish the "Tibetan-intervened" and "Yorkshire-intervened" porcine models...
June 12, 2017: Scientific Reports
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