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https://www.readbyqxmd.com/read/28323866/elevated-fecal-peptidase-d-at-onset-of-colitis-in-galphai2-mice-a-mouse-model-of-ibd
#1
Daniel Bergemalm, Robert Kruse, Maria Sapnara, Jonas Halfvarson, Elisabeth Hultgren Hörnquist
BACKGROUND: The identification of novel fecal biomarkers in inflammatory bowel disease (IBD) is hampered by the complexity of the human fecal proteome. On the other hand, in experimental mouse models there is probably less variation. We investigated the fecal protein content in mice to identify possible biomarkers and pathogenic mechanisms. METHODS: Fecal samples were collected at onset of inflammation in Galphai2-/- mice, a well-described spontaneous model of chronic colitis, and from healthy littermates...
2017: PloS One
https://www.readbyqxmd.com/read/28322843/the-effect-of-menthol-on-acute-experimental-colitis-in-rats
#2
Masoumeh Ghasemi-Pirbaluti, Ehsan Motaghi, Homan Bozorgi
Menthol is an aromatic compound with high antiinflammatory activity. The purpose of the current research is to investigate the effectiveness of menthol on acetic acid induced acute colitis in rats. Animals were injected with menthol (20 and 50 and 80mg/kg, i.p.) 24h prior to induction of colitis for 3 consecutive days. Menthol at medium and higher doses similar to dexamethasone as a reference drug significantly reduced body weight loss, macroscopic damage score, ulcer area, colon weight, colon length and improved hematocrit in rats with colitis...
March 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28293641/functional-effects-of-prebiotic-fructans-in-colon-cancer-and-calcium-metabolism-in-animal-models
#3
Marisol Rivera-Huerta, Vania Lorena Lizárraga-Grimes, Ibrahim Guillermo Castro-Torres, Mabel Tinoco-Méndez, Lucía Macías-Rosales, Francisco Sánchez-Bartéz, Graciela Guadalupe Tapia-Pérez, Laura Romero-Romero, María Isabel Gracia-Mora
Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin "Synergy 1®" and inulin from Mexican agave "Metlin®" in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28293233/the-soil-bacterium-methylococcus-capsulatus-bath-interacts-with-human-dendritic-cells-to-modulate-immune-function
#4
Stine Indrelid, Charlotte Kleiveland, René Holst, Morten Jacobsen, Tor Lea
The prevalence of inflammatory bowel disease (IBD) has increased in Western countries during the course of the twentieth century, and is evolving to be a global disease. Recently we showed that a bacterial meal of a non-commensal, non-pathogenic methanotrophic soil bacterium, Methylococcus capsulatus Bath prevents experimentally induced colitis in a murine model of IBD. The mechanism behind the effect has this far not been identified. Here, for the first time we show that M. capsulatus, a soil bacterium adheres specifically to human dendritic cells, influencing DC maturation, cytokine production, and subsequent T cell activation, proliferation and differentiation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28291990/medicinal-plants-in-the-treatment-of-colitis-evidence-from-preclinical-studies
#5
Marília T Santana, Luana M Cercato, Janaíne P Oliveira, Enilton A Camargo
Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using "medicinal plants" and "ulcerative colitis" as key words...
March 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28288330/the-pharmacodynamic-active-components-study-of-tibetan-medicine-gentianopsis-paludosa-on-ulcerative-colitis-fibrosis
#6
Nian-Hua Lu, Hui-Qiao Zhao, Ming Jing, Xiong Liu, Chun-Zhen Ren, Xue-Feng Liu, Juan-Juan Liu, Yan-Xia Zhang
The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-extract of Gentianopsis paludosa. Masson staining and qRT-PCR methods were respectively used to assess the degree of UC fibrosis and detect the mRNA expressions of collagen I, collagen III, a-smooth muscle actin (α-SMA) and E-cadherin in colon tissue...
March 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28284792/screening-of-the-optimized-prescription-from-suqingwan-in-terms-of-its-therapeutic-effect-on-dss-induced-ulcerative-colitis-by-its-regulation-of-inflammatory-and-oxidative-mediators
#7
Jingxuan Shao, Zhihui Liu, Lin Wang, Zehai Song, Hang Chang, Na Han, Jun Yin
ETHNOPHARMACOLOGICAL RELEVANCE: Suqingwan (SQW), a traditional Chinese medicine used for treating ulcerative colitis (UC), is composed of 13 kinds of Traditional Chinese medicines (TCMs). According to TCM theory, we investigated whether a simplified prescription composed of the herbs with some functions, would have similar effects to SQW and examined its potential treatment mechanism of action. MATERIALS AND METHODS: We categorized the herbs in SQW into four groups according to their traditional functions and used an orthogonal experimental design to obtain nine separated prescriptions (SPs) of SQW...
March 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28283650/culturing-human-intestinal-stem-cells-for-regenerative-applications-in-the-treatment-of-inflammatory-bowel-disease
#8
REVIEW
Fredrik Eo Holmberg, Jakob B Seidelin, Xiaolei Yin, Benjamin E Mead, Zhixiang Tong, Yuan Li, Jeffrey M Karp, Ole H Nielsen
Both the incidence and prevalence of inflammatory bowel disease (IBD) is increasing globally; in the industrialized world up to 0.5% of the population are affected and around 4.2 million individuals suffer from IBD in Europe and North America combined. Successful engraftment in experimental colitis models suggests that intestinal stem cell transplantation could constitute a novel treatment strategy to re-establish mucosal barrier function in patients with severe disease. Intestinal stem cells can be grown in vitro in organoid structures, though only a fraction of the cells contained are stem cells with regenerative capabilities...
March 10, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28276713/aberrant-function-of-myeloid-derived-suppressor-cells-mdscs-in-experimental-colitis-and-in-inflammatory-bowel-disease-ibd-immune-responses
#9
Eleni Kontaki, Dimitrios T Boumpas, Maria Tzardi, Ioannis A Mouzas, Konstantinos A Papadakis, Panayotis Verginis
BACKGROUND AND AIMS: Myeloid-derived suppressor cells (MDSCs) encompass a novel population of suppressor cells and a potential candidate for cell-based therapies in inflammatory diseases. Herein, we investigated their immunomodulatory properties in experimental inflammatory colitis and T cell-mediated immune responses in inflammatory bowel disease (IBD) patients. METHODS: MDSCs (defined as CD14(-)HLA(-)DR(-/low)CD33(+)CD15(+)) numbers were determined in peripheral blood (PB) from IBD patients...
March 3, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28275298/jianpi-qingchang-decoction-alleviates-ulcerative-colitis-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-activation
#10
Lie Zheng, Ya-Li Zhang, Yan-Cheng Dai, Xuan Chen, De-Liang Chen, Yue-Ting Dai, Zhi-Peng Tang
AIM: To investigate the therapeutic effect of Jianpi Qingchang decoction (JPQCD) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group were treated with standard drinking water, without DSS. After 7 d, the DSS drinking water was changed to normal water and the DSS group continued with DSS water...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28272365/simultaneous-determination-of-three-furanocoumarins-by-uplc-ms-ms-application-to-pharmacokinetic-study-of-angelica-dahurica-radix-after-oral-administration-to-normal-and-experimental-colitis-induced-rats
#11
Youn-Hwan Hwang, Hye Jin Yang, Jin Yeul Ma
In traditional oriental medicine, Angelica dahurica Radix (ADR) is used in the treatment of gastrointestinal, respiratory, neuromuscular, and dermal disorders. We evaluated the pharmacokinetic profiles of oxypeucedanin, imperatorin, and isoimperatorin, major active ingredients of ADR, in normal and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats. A rapid, sensitive, and validated UPLC/MS/MS method was established for evaluating the pharmacokinetics of three furanocoumarins. After oral administration of ADR (0...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28267767/maternal-exposure-to-low-levels-of-corticosterone-during-lactation-protects-adult-rat-progeny-against-tnbs-induced-colitis-a-study-on-gr-mediated-anti-inflammatory-effect-and-prokineticin-system
#12
Manuela Zinni, Anna Rita Zuena, Veronica Marconi, Carla Petrella, Ilaria Fusco, Chiara Giuli, Nadia Canu, Cinzia Severini, Maria Broccardo, Vassilia Theodorou, Roberta Lattanzi, Paola Casolini
The early phase of life represents a critical period for the development of an organism. Interestingly, early life experiences are able to influence the development of the gastrointestinal tract and the reactivity to colonic inflammatory stress. We recently demonstrated that adult male rats exposed to low doses of corticosterone during lactation (CORT-nursed rats) are protected against experimental colitis induced by the intracolonic infusion of 2,4,6-trinitrobenzenesulfonic acid (TNBS). Based on these interesting results, we wanted to better investigate which cellular actors could be involved in the protection of CORT-nursed rats from TNBS-induced experimental colitis...
2017: PloS One
https://www.readbyqxmd.com/read/28267639/evaluation-of-anti-inflammatory-effect-of-silver-coated-glass-beads-in-mice-with-experimentally-induced-colitis-as-a-new-type-of-treatment-in-inflammatory-bowel-disease
#13
Krzysztof Siczek, Hubert Zatorski, Anna Chmielowiec-Korzeniowska, Radzisław Kordek, Leszek Tymczyna, Jakub Fichna
BACKGROUND: Recent studies point at the anti-inflammatory action of silver through induction of apoptosis of inflammatory cells via oxidative stress, promotion of wound healing as well as antimicrobial effect. Our aim was to design a new formulation based on silver and validate its anti-inflammatory activity in the mouse models of colitis. METHODS: Silver-coated glass beads were prepared using a magnetron sputtering method and a standard magnetron sputtering gun equipped with pure silver target...
January 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28267439/mechanisms-of-colitis-accelerated-colon-carcinogenesis-and-its-prevention-with-the-combination-of-aspirin-and-curcumin-transcriptomic-analysis-using-rna-seq
#14
Yue Guo, Zheng-Yuan Su, Chengyue Zhang, John M Gaspar, Rui Wang, Ronald P Hart, Michael P Verzi, Ah-Ng Tony Kong
Colorectal cancer (CRC) remains the leading cause of cancer-related death in the world. Aspirin (ASA) and curcumin (CUR) are widely investigated chemopreventive candidates for CRC. However, the precise mechanisms of their action and their combinatorial effects have not been evaluated. The purpose of the present study was to determine the effect of ASA, CUR, and their combination in azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-accelerated colorectal cancer (CAC). We also aimed to characterize the differential gene expression profiles in AOM/DSS-induced tumors as well as in tumors modulated by ASA and CUR using RNA-seq...
March 3, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28260798/geniposide-ameliorates-tnbs-induced-experimental-colitis-in-rats-via-reducing-inflammatory-cytokine-release-and-restoring-impaired-intestinal-barrier-function
#15
Bin Xu, Yan-Li Li, Ming Xu, Chang-Chun Yu, Meng-Qiao Lian, Ze-Yao Tang, Chuan-Xun Li, Yuan Lin
Geniposide is an iridoid glycosides purified from the fruit of Gardenia jasminoides Ellis, which is known to have antiinflammatory, anti-oxidative and anti-tumor activities. The present study aimed to investigate the effects of geniposide on experimental rat colitis and to reveal the related mechanisms. Experimental rat colitis was induced by rectal administration of a TNBS solution. The rats were treated with geniposide (25, 50 mg·kg(-1)·d(-1), ig) or with sulfasalazine (SASP, 100 mg·kg(-1)·d(-1), ig) as positive control for 14 consecutive days...
March 6, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28259987/abnormal-differentiation-of-stem-cells-into-enteroendocrine-cells-in-rats-with-dss-induced-colitis
#16
Magdy El-Salhy, Kazuo Umezawa, Jan Gunnar Hatlebakk, Odd Helge Gilja
The present study aimed to determine whether there is an association between abnormalities in enteroendocrine cells in dextran sulfate sodium (DSS)‑induced colitis and the clonogenic and/or proliferative activities of stem cells. A total of 48 male Wistar rats were divided into four groups. Animals in the control group were provided with normal drinking water, whereas DSS colitis was induced in the remaining three groups. The rats with DSS‑induced colitis were randomized into the following three groups: i) DSS group, which received 0...
March 1, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259136/therapeutic-effects-of-different-doses-of-polyethylene-glycosylated-porcine-glucagon-like-peptide-2-on-ulcerative-colitis-in-male-rats
#17
Ke-Ke Qi, Jia-Jia Lv, Jie Wu, Zi-Wei Xu
BACKGROUND: Polyethylene glycosylated (PEGylated) porcine glucagon-like peptide-2 (pGLP-2) considerably increases half-life and stability compared with the native pGLP-2, but the effective dose for intestinal damage is still unclear. This study aims to evaluate the available dose of polyethylene glycosylated porcine glucagon-like peptide-2 (PEG-pGLP-2), a modified, long-acting form of pGLP-2 in an experimental rat model of ulcerative colitis. METHODS: Thirty-five male rats were randomly assigned into five groups: control, dextran sodium sulphate (DSS), DSS + PEG-pGLP-2(L), DSS + PEG-pGLP-2(M) and DSS + PEG-pGLP-2(H)...
March 4, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28252200/exploration-of-inflammatory-bowel-disease-in-mice-chemically-induced-murine-models-of-inflammatory-bowel-disease-ibd
#18
Raffaella Maria Gadaleta, Oihane Garcia-Irigoyen, Antonio Moschetta
Inflammatory bowel disease (IBD) is a chronic multifactorial inflammatory disorder characterized by periods of activation and remission of intestinal inflammation, with potentially severe complications, that can lead to mortality. Experimental animal models of intestinal inflammation are crucial for understanding the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), the two major human IBD phenotypes. Animal models have been instrumental in unveiling the molecular background of IBD, and although a single model is not able to capture the complexity of this disease, each of them provided valuable insight into its different aspects...
March 2, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/28246471/microrna-155-promotes-the-pathogenesis-of-experimental-colitis-by-repressing-ship-1-expression
#19
Zhan-Jun Lu, Jian-Jiong Wu, Wei-Liang Jiang, Jun-Hua Xiao, Kai-Zhong Tao, Lei Ma, Ping Zheng, Rong Wan, Xing-Peng Wang
AIM: To explore the mechanism by which microRNA-155 (miR-155) regulates the pathogenesis of experimental colitis. METHODS: A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3'-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established and then utilized in gain- and loss-of-function studies performed in raw264.7 cells and primary bone marrow-derived macrophages (BMDMs). Thereafter, dextran sulfate sodium (DSS)-induced colitis mouse model with or without antagomiR-155 treatment was established, and the levels of miR-155 and SHIP-1, as well as the pro-inflammatory capabilities, were measured by western blot, quantitative polymerase chain reaction, and immunohistochemistry...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28230865/erbb4-signaling-stimulates-pro-inflammatory-macrophage-apoptosis-and-limits-colonic-inflammation
#20
Michael A Schumacher, Matija Hedl, Clara Abraham, Jessica K Bernard, Patricia R Lozano, Jonathan J Hsieh, Dana Almohazey, Edie B Bucar, Shivesh Punit, Peter J Dempsey, Mark R Frey
Efficient clearance of pro-inflammatory macrophages from tissues after resolution of a challenge is critical to prevent prolonged inflammation. Defects in clearance can contribute to conditions such as inflammatory bowel disease, and thus may be therapeutically targetable. However, the signaling pathways that induce termination of pro-inflammatory macrophages are incompletely defined. We tested whether the ErbB4 receptor tyrosine kinase, previously not known to have role in macrophage biology, is involved in this process...
February 23, 2017: Cell Death & Disease
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