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https://www.readbyqxmd.com/read/28531922/protective-effect-of-averrhoa-bilimbi-l-fruit-extract-on-ulcerative-colitis-in-wistar-rats-via-regulation-of-inflammatory-mediators-and-cytokines
#1
Jagadish Kumar Suluvoy, Sakthivel K M, Guruvayoorappan C, Berlin Grace V M
Ulcerative Colitis (UC) is a lingering type of Inflammatory Bowel Disease (IBD) which affects the colon mucosa. Ulcerative colitis is majorly associated with oxidative stress and inflammation in colon tissue leading to damage. Averrhoa bilimbi L. fruit is rich in antioxidant phytochemicals including Vitamin C. In the current research, we have evaluated the defence mechanism of Averrhoa bilimbi L. on Ulcerative Colitis (UC). Male wistar rats were treated with Averrhoa bilimbi L. fruit extract (50mg/kg/bwt and 100mg/kg/bwt) and a standard drug Sulfasalazine (100mg/kg/bwt) for 6 consecutive days via intra peritoneally...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28528363/caffeic-acid-phenethyl-ester-is-protective-in-experimental-ulcerative-colitis-via-reduction-in-levels-of-pro-inflammatory-mediators-and-enhancement-of-epithelial-barrier-function
#2
Mohammed N Khan, Majella E Lane, Paul A McCarron, Murtaza M Tambuwala
BACKGROUND: Inhibition of the nuclear factor kappa beta (NF-κβ) pathway has been proposed as a therapeutic target due to its key role in the expression of pro-inflammatory genes, including pro-inflammatory cytokines, chemokines, and adhesion molecules. Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, and has been reported as a specific inhibitor of NF-κβ. However, the impact of CAPE on levels of myeloperoxidases (MPO) and pro-inflammatory cytokines during inflammation is not clear...
May 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28515278/critical-role-of-p2y12-receptor-in-regulation-of-th17-differentiation-and-experimental-autoimmune-encephalomyelitis-pathogenesis
#3
Chaoyan Qin, Jinfeng Zhou, Yuan Gao, Weiming Lai, Cuixia Yang, Yingying Cai, Shuai Chen, Changsheng Du
Adenosine 5'-diphosphate is a key endogenous cell-signaling molecule that can activate P2 purinergic receptor family members. ADP-P2Y signaling is reported to be associated with inflammation, but its function in T cell differentiation and autoimmune diseases pathogenesis is unclear. In this study, we found that the P2Y12 receptor was upregulated in the peripheral immune tissues of experimental autoimmune encephalomyelitis (EAE) mice. Deficiency of P2Y12 led to a reduced peak severity and cumulative disease score in EAE mice, followed by a dramatic reduction of leukocyte infiltration and less extensive demyelination...
May 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28509629/nanoparticle-based-delivery-enhances-anti-inflammatory-effect-of-low-molecular-weight-heparin-in-experimental-ulcerative-colitis
#4
Tawfek Yazeji, Brice Moulari, Arnaud Beduneau, Valentin Stein, Dirk Dietrich, Yann Pellequer, Alf Lamprecht
Epithelial administration of low molecular weight heparin (LMWH) has proven its therapeutic efficiency in ulcerative colitis (UC) but still lacks of a sufficiently selective drug delivery system. Polymeric nanoparticles were used here not only to protect LMWH from intestinal degradation but also to provide targeted delivery to inflamed tissue in experimental colitis mice. LMWH was associated with polymethacrylate nanoparticles (NP) type A (PEMT-A) or type B (PEMT-B) of a size: 150 nm resulting in a maximum drug loading: 0...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28502906/anti-inflammatory-effects-of-forsythia-suspensa-in-dextran-sulfate-sodium-induced-colitis
#5
Youn-Hwan Hwang, Dong-Gun Kim, Wei Li, Hye Jin Yang, Nam-Hui Yim, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa Fructus (FS) is used to treat various inflammatory disorders in traditional Oriental medicine, including gastrointestinal diseases, but its therapeutic potential in ulcerative colitis is unclear. Thus, we investigated any potential therapeutic effects of FS against intestinal inflammation and the bioactive constituents in FS. MATERIALS AND METHODS: After the induction of colitis using 3% dextran sulfate sodium, FS (100mg/kg/day) was administered orally during the experimental period...
May 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28501138/submucosal-neurons-and-enteric-glial-cells-expressing-the-p2x7-receptor-in-rat-experimental-colitis
#6
Marcos Vinícius da Silva, Aline Rosa Marosti, Cristina Eusébio Mendes, Kelly Palombit, Patricia Castelucci
The aim of this study was to evaluate the effect of ulcerative colitis on the submucosal neurons and glial cells of the submucosal ganglia of rats. 2,4,6-Trinitrobenzene sulfonic acid (TNBS; colitis group) was administered in the colon to induce ulcerative colitis, and distal colons were collected after 24h. The colitis rats were compared with those in the sham and control groups. Double labelling of the P2X7 receptor with calbindin (marker for intrinsic primary afferent neurons, IPANs, submucosal plexus), calretinin (marker for secretory and vasodilator neurons of the submucosal plexus), HuC/D and S100β was performed in the submucosal plexus...
May 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28494341/dyospiros-kaki-phenolics-inhibit-colitis-and-colon-cancer-cell-proliferation-but-not-gelatinase-activities
#7
Rosa Direito, Ana Lima, João Rocha, Ricardo Boavida Ferreira, Joana Mota, Patrícia Rebelo, Adelaide Fernandes, Rui Pinto, Paula Alves, Rosário Bronze, Bruno Sepodes, Maria-Eduardo Figueira
Polyphenols from persimmon (Diospyros kaki) have demonstrated radical-scavenging and antiinflammatory activities; however, little is known about the effects of persimmon phenolics on inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Therefore, we aimed in this work to characterize the antiinflammatory and antiproliferative effects of a persimmon phenolic extract (80% acetone in water), using an in vivo model of experimental colitis and a model of cancer cell invasion. Our results show, for the first time, a beneficial effect of a persimmon phenolic extract in the attenuation of experimental colitis and a potential antiproliferative effect on cultured colon cancer cells...
March 30, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28493993/mechanism-of-down-regulation-of-na-h-exchanger-2-in-experimental-colitis
#8
Amal Ali Soleiman, Farook Thameem, Islam Khan
BACKGROUND: The Na-H exchanger [NHE] performs an electroneutral uptake of NaCl and water from the lumen of the gastrointestinal tract. There are several distinct NHE isoforms, some of which show an altered expression in the inflammatory bowel diseases (IBD). In this study, we examined a role of NHE-2 in experimental colitis. METHODS: Colitis was induced in male Sprague-Dawley rats by intra-rectal administration of trinitrobenzenesulphonic acid (TNBS). On day 6 post-TNBS, the animals were sacrificed, colonic and ileal segments were taken out, cleaned with phosphate buffered saline and used in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28493876/the-effect-of-sphingosine-1-phosphate-on-colonic-smooth-muscle-contractility-modulation-by-tnbs-induced-colitis
#9
Aishah Al-Jarallah, Mabayoje Oriowo
AIM: Increased levels of circulating sphingosine-1-phosphate (S1P) have been reported in ulcerative colitis. The objective of this study was to examine the effect of S1P on colonic smooth muscle contractility and how is it affected by colitis. METHODS: Colonic inflammation was induced by intrarectal administration of trinitrobenzene sulfonic acid. Five days later colon segments were isolated and used for contractility experiments and immunoblotting. RESULTS: S1P contracted control and inflamed colon segments and the contraction was significantly greater in inflamed colon segments...
2017: PloS One
https://www.readbyqxmd.com/read/28490634/inflammatory-cytokines-down-regulate-the-barrier-protective-prostasin-matriptase-proteolytic-cascade-early-in-experimental-colitis
#10
Marguerite S Buzza, Tierra A Johnson, Gregory D Conway, Erik W Martin, Subhradip Mukhopadhyay, Terez Shea-Donohue, Toni M Antalis
Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of IBD, Ulcerative Colitis (UC) and Crohns disease (CD). Matriptase is a membrane-anchored serine protease encoded by Suppression of Tumorigenicity-14 (ST14) gene, which is critical for epithelial barrier development and homeostasis. Matriptase barrier protective activity is linked with the glycosyl-phosphatidyl-inositol (GPI)-anchored serine protease prostasin, which is a co-factor for matriptase zymogen activation...
May 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28487310/myeloid-derived-mir-223-regulates-intestinal-inflammation-via-repression-of-the-nlrp3-inflammasome
#11
Viola Neudecker, Moritz Haneklaus, Owen Jensen, Ludmila Khailova, Joanne C Masterson, Hazel Tye, Kathryn Biette, Paul Jedlicka, Kelley S Brodsky, Mark E Gerich, Matthias Mack, Avril A B Robertson, Matthew A Cooper, Glenn T Furuta, Charles A Dinarello, Luke A O'Neill, Holger K Eltzschig, Seth L Masters, Eóin N McNamee
MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation. miR-223(-/y) mice presented with exacerbated myeloid-driven experimental colitis with heightened clinical, histopathological, and cytokine readouts...
May 9, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28487234/anti-inflammatory-action-of-angiotensin-1-7-in-experimental-colitis-may-be-mediated-through-modulation-of-serum-cytokines-chemokines-and-immune-cell-functions
#12
Maitham A Khajah, Maryam M Fateel, Kethireddy V Ananthalakshmi, Yunus A Luqmani
We recently demonstrated Ang 1-7 reduced inflammation in the dextran sulfate sodium (DSS) colitis model. In this study we examined the effect of Ang 1-7 on modulation of plasma levels of selected cytokines and chemokines and immune cell effector functions (apoptosis, chemotaxis and superoxide release) in vitro. The degree of neutrophil recruitment to the colon was assessed by immunofluorescence and myeloperoxidase activity. Daily Ang 1-7 treatment at 0.01 mg/kg dose which previously ameliorated colitis severity, showed a significant reduction in circulating levels of several cytokines and chemokines, and neutrophil recruitment to the colonic tissue...
May 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28486400/growth-hormone-resistance-special-focus-on-inflammatory-bowel-disease
#13
REVIEW
Christoffer Soendergaard, Jonathan A Young, John J Kopchick
Growth hormone (GH) plays major anabolic and catabolic roles in the body and is important for regulating several aspects of growth. During an inflammatory process, cells may develop a state of GH resistance during which their response to GH stimulation is limited. In this review, we will emphasize specific mechanisms governing the formation of GH resistance in the active phase of inflammatory bowel disease. The specific molecular effects mediated through individual inflammatory mediators and processes will be highlighted to provide an overview of the transcriptional, translational and post-translational inflammation-mediated impacts on the GH receptor (GHR) along with the impacts on GH-induced intracellular signaling...
May 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28485605/-influence-of-dimerization-of-apocynin-on-its-effects-in-experimental-colitis
#14
Marta Marin, Clotilde Gimeno, Rosa M Giner, Jose Luis Rios, Salvador Mañez, M C Recio
Apocynin has been widely used as an inhibitor of nicotinamide adenine dinucleotide phosphatase oxidase (NADPH-oxidase) system and shows promise as an anti-inflammatory drug. Diapocynin, the dimeric product generated by the oxidation of apocynin in presence of myeloperoxidase (MPO), is supposed to be its active form. In this study, diapocynin has been chemically synthesized and analyzed its activity on several inflammatory mediators in LPS-stimulated RAW264.7 macrophages and its anti-inflammatory effect on ulcerative colitis induced by dextran sodium sulfate (DSS) in mice...
May 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28476379/prdm5-promotes-the-apoptosis-of-epithelial-cells-induced-by-ifn-%C3%AE-during-crohn-s-disease
#15
Han Wu, Liang Wang, Dongmei Zhang, Ji Qian, Lijun Yan, Qiyun Tang, Runzhou Ni, Xiaoping Zou
Elevated apoptosis of intestinal epithelial cells (IECs) greatly impairs the epithelial barrier integrity and contributes to the pathogenesis of Crohn's Disease (CD). Overproduction of pro-inflammatory cytokine Interferon-γ (IFN-γ) induces the excessive apoptosis of IECs and is involved in CD development. PRDM5 (PR domain containing 5 PFM2) a member of PRDM family, reportedly acts as a transcriptional regulator involved in tissue specific differentiation and tumor development. In this study, we investigated PRDM5 expression and its potential functions in both human CD (Crohn's disease) and TNBS (2,4,6-trinitrobenzenesulfonic acid sol)-induced mice experimental colitis...
December 5, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28472309/impact-on-experimental-colitis-of-vitamin-d-receptor-deletion-in-intestinal-epithelial-or-myeloid-cells
#16
Carlien Leyssens, Lieve Verlinden, Gert De Hertogh, Shigeaki Kato, Conny Gysemans, Chantal Mathieu, Geert Carmeliet, Annemieke Verstuyf
Inflammatory bowel diseases are gastrointestinal diseases including Crohn's disease and ulcerative colitis. The chronic inflammation is thought to result from an excessive inflammatory response to environmental factors such as luminal bacteria in genetically predisposed individuals. Studies revealed that mice with impaired vitamin D signaling are more susceptible to experimental colitis. To better understand the contribution of vitamin D signaling in different cells of the gut to this disease, we investigated the effects of intestinal-specific or myeloid vitamin D receptor deletion...
May 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28472257/expression-of-ecto-nucleoside-triphosphate-diphosphohydrolases-2-and-3-in-the-enteric-nervous-system-impacts-inflammation-in-experimental-colitis-and-crohn-s-disease
#17
Linda Feldbrügge, Alan C Moss, Eric U Yee, Eva Csizmadia, Shuji Mitsuhashi, Maria Serena Longhi, Bynvant Sandhu, Holger Stephan, Yan Wu, Adam S Cheifetz, Christa E Müller, Jean Sévigny, Simon C Robson, Z Gordon Jiang
Objective: Recent studies have suggested that the enteric nervous system can modulate gut immunity. Ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases) regulate purinergic signaling by sequential phosphohydrolysis of pro-inflammatory extracellular ATP. Herein, we test the hypothesis that E-NTPDases modulate gut inflammation via neuro-immune crosstalk. Design: We determined expression patterns of NTPDase2 and NTPDase3 in murine and human colon. Experimental colitis was induced by dextran sodium sulfate (DSS) in genetically engineered mice deficient in NTPDase2 or NTPDase3...
May 2, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28469075/bilirubin-suppresses-th17-immunity-in-colitis-by-upregulating-cd39
#18
Maria Serena Longhi, Marta Vuerich, Alireza Kalbasi, Jessica E Kenison, Ada Yeste, Eva Csizmadia, Byron Vaughn, Linda Feldbrugge, Shuji Mitshuhashi, Barbara Wegiel, Leo Otterbein, Alan Moss, Francisco J Quintana, Simon C Robson
Unconjugated bilirubin (UCB), a product of heme oxidation, has known immunosuppressant properties but the molecular mechanisms, other than antioxidant effects, remain largely unexplored. We note that UCB modulates T helper type 17 (Th17) immune responses, in a manner dependent upon heightened expression of CD39 ectonucleotidase. UCB has protective effects in experimental colitis, where it enhances recovery after injury and preferentially boosts IL-10 production by colonic intraepithelial CD4+ cells. In vitro, UCB confers immunoregulatory properties on human control Th17 cells, as reflected by increased levels of FOXP3 and CD39 with heightened cellular suppressor ability...
May 4, 2017: JCI Insight
https://www.readbyqxmd.com/read/28466862/erratum-geniposide-ameliorates-tnbs-induced-experimental-colitis-in-rats-via-reducing-inflammatory-cytokine-release-and-restoring-impaired-intestinal-barrier-function
#19
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28456797/identification-of-two-additional-susceptibility-loci-for-inflammatory-bowel-disease-in-a-chinese-population
#20
Xiucai Lan, Xiuhua Lan, Ying Chang, Xiaomin Zhang, Jing Liu, Vikash Vikash, Wei Wang, Meifang Huang, Xiaobing Wang, Feng Zhou, Liping Chen, Qiu Zhao
BACKGROUND/AIMS: To investigate the associations between the rs1250569 (zinc finger MIZ-type containing 1, ZMIZ1), rs1042522 (tumour protein p53, TP53), and rs10114470 (tumour necrosis factor-like cytokine 1A, TL1A) polymorphisms and the development of inflammatory bowel disease (IBD) in a Chinese (Han) population. We analysed the expression of genes that predispose patients to Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A total of 381 IBD patients and 517 healthy controls were recruited into our study...
April 14, 2017: Cellular Physiology and Biochemistry
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