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https://www.readbyqxmd.com/read/27932984/curcumin-suppressed-activation-of-dendritic-cells-via-jak-stat-socs-signal-in-mice-with-experimental-colitis
#1
Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu, Duan-Yong Liu
Dendritic cells (DCs) play a pivotal role as initiators in the pathogenesis of inflammatory bowel disease and are regulated by the JAK/STAT/SOCS signaling pathway. As a potent anti-inflammatory compound, curcumin represents a viable treatment alternative or adjunctive therapy in the management of chronic inflammatory bowel disease (IBD). The mechanism of curcumin treated IBD on DCs is not completely understood. In the present study, we explored the mechanism of curcumin treated experimental colitis by observing activation of DCs via JAK/STAT/SOCS signaling pathway in colitis mice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932504/expression-of-cav1-3-calcium-channel-in-the-human-and-mouse-colon-post-transcriptional-inhibition-by-ifn%C3%AE
#2
Vijayababu M Radhakrishnan, Maryam M Gilpatrick, Nouralhoda Dehdashti, Pawel R Kiela, Fayez K Ghishan
It has been hypothesized that apically expressed L-type Ca(2+) channel Cav1.3 (encoded by CACNA1D gene) contributes towards an alternative TRPV6-independent route of intestinal epithelial Ca(2+) absorption, especially during digestion when high luminal concentration of Ca(2+) and other nutrients limit TRPV6 contribution. We and others have implicated altered expression and activity of key mediators of intestinal and renal Ca(2+) (re)absorption as contributors to negative systemic Ca2+ balance and bone loss in intestinal inflammation...
December 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27930969/rhapontin-ameliorates-colonic-epithelial-dysfunction-in-experimental-colitis-through-sirt1-signaling
#3
Wencheng Wei, Lei Wang, Kai Zhou, Haifeng Xie, Mian Zhang, Chaofeng Zhang
Rhapontin (3, 3', 5-trihydroxy-4'-methoxystilbene-3-O-glucoside) has anti-thrombotic, anti-allergic and anti-diabetic activities. This study aimed to assess the protective effects of rhapontin on intestinal damage in vivo and in vitro. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of rhapontin (100mg/kg) significantly attenuated colonic pathological damage and remarkably inhibited infiltration by inflammatory cells, myeloperoxidase (MPO) activity, NLRP3 inflammasome activation and SIRT1 expression in the colon...
December 5, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27930307/cosmc-is-an-x-linked-inflammatory-bowel-disease-risk-gene-that-spatially-regulates-gut-microbiota-and-contributes-to-sex-specific-risk
#4
Matthew R Kudelka, Benjamin H Hinrichs, Trevor Darby, Carlos S Moreno, Hikaru Nishio, Christopher E Cutler, Jianmei Wang, Huixia Wu, Junwei Zeng, Yingchun Wang, Tongzhong Ju, Sean R Stowell, Asma Nusrat, Rheinallt M Jones, Andrew S Neish, Richard D Cummings
Inflammatory bowel disease (IBD) results from aberrant immune stimulation against a dysbiotic mucosal but relatively preserved luminal microbiota and preferentially affects males in early onset disease. However, factors contributing to sex-specific risk and the pattern of dysbiosis are largely unexplored. Core 1 β3GalT-specific molecular chaperone (Cosmc), which encodes an X-linked chaperone important for glycocalyx formation, was recently identified as an IBD risk factor by genome-wide association study. We deleted Cosmc in mouse intestinal epithelial cells (IECs) and found marked reduction of microbiota diversity in progression from the proximal to the distal gut mucosa, but not in the overlying lumen, as seen in IBD...
December 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27920472/anti-inflammatory-effect-of-cannabinoid-agonist-win55-212-on-mouse-experimental-colitis-is-related-to-inhibition-of-p38mapk
#5
Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao
AIM: To investigate the anti-inflammatory effect and the possible mechanisms of an agonist of cannabinoid (CB) receptors, WIN55-212-2 (WIN55), in mice with experimental colitis, so as to supply experimental evidence for its clinical use in future. METHODS: We established the colitis model in C57BL/6 mice by replacing the animals' water supply with 4% dextran sulfate sodium (DSS) for 7 consecutive days. A colitis scoring system was used to evaluate the severity of colon local lesion...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27915991/control-of-inflammatory-bowel-disease-and-colorectal-cancer-by-synthetic-vitamin-d-receptor-ligands
#6
Ichiro Takada, Makoto Makishima
Vitamin D deficiency and insufficiency are associated with an increased risk of cancer, autoimmune disease, inflammation, infection, cardiovascular disease and metabolic disease, as well as bone and mineral disorders. The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression. The secondary bile acid lithocholic acid, which is produced by intestinal bacteria, is another natural VDR ligand...
December 2, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27888115/application-of-carbon-nanotubes-as-the-carriers-of-the-cannabinoid-2-arachidonoylglycerol-towards-a-novel-treatment-strategy-in-colitis
#7
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand
AIMS: Treatment of colitis has remained a major clinical challenge. The cannabinoid, 2-arachidonoyglycerol (2-AG), has shown beneficial effects in colitis, however, poor solubility or rapid hydrolysis may limit its efficiency. According to the high biocompatibility of carbon nanotubes (CNTs) and their ability for controlled drug delivery, we aimed to prepare multi-walled CNTs-2-AG (MWCNTs-2-AG) complex in order to improve the pharmacological profile of 2-AG and evaluate the therapeutic potential of this nanocomplex in a rat model of colitis...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27878645/the-synaptojanins-in-the-murine-small-and-large-intestine
#8
María Dolores Vázquez-Carretero, Ana Eloisa Carvajal, José Manuel Serrano-Morales, Pablo García-Miranda, Anunciación Ana Ilundain, María José Peral
The expression of the phosphoinositides phosphatases Synaptojanins (Synjs) 1 and 2 has been shown in brain and in some peripheral tissues, but their expression in the intestine has not been reported. Herein we show that the small and large intestine express Synj1 and Synj2. Their mRNA levels, measured by RT-PCR, are not affected by development in the small intestine but in the colon they increase with age. Immunostaining assays reveal that both Synjs localize at the apical domain of the epithelial cells and at the lamina propria at sites also expressing the neuron marker calretinin...
December 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27877040/intestinal-anti-inflammatory-effects-of-rgd-functionalized-silk-fibroin-nanoparticles-in-trinitrobenzenesulfonic-acid-induced-experimental-colitis-in-rats
#9
Alba Rodriguez-Nogales, Francesca Algieri, Laura De Matteis, A Abel Lozano-Perez, Jose Garrido-Mesa, Teresa Vezza, J M de la Fuente, Jose Luis Cenis, Julio Gálvez, Maria Elena Rodriguez-Cabezas
BACKGROUND: Current treatment of inflammatory bowel disease is based on the use of immunosuppressants or anti-inflammatory drugs, which are characterized by important side effects that can limit their use. Previous research has been performed by administering these drugs as nanoparticles that target the ulcerated intestinal regions and increase their bioavailability. It has been reported that silk fibroin can act as a drug carrier and shows anti-inflammatory properties. PURPOSE: This study was designed to enhance the interaction of the silk fibroin nanoparticles (SFNs) with the injured intestinal tissue by functionalizing them with the peptide motif RGD (arginine-glycine-aspartic acid) and to evaluate the intestinal anti-inflammatory properties of these RGD-functionalized silk fibroin nanoparticles (RGD-SFNs) in the trinitrobenzenesulfonic acid (TNBS) model of rat colitis...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27873546/evaluation-of-the-effect-of-soymilk-fermented-by-a-riboflavin-producing-lactobacillus-plantarum-strain-in-a-murine-model-of-colitis
#10
R Levit, G Savoy de Giori, A de Moreno de LeBlanc, J G LeBlanc
Inflammatory bowel diseases (IBD) are idiopathic diseases of the gastrointestinal tract characterised by recurrent inflammation that require lifelong treatments. It has been shown that certain strains of lactic acid bacteria (LAB) can produce specific health-promoting compounds in foods or in the gastrointestinal tract that can in turn prevent and/or treat IBD. This study was designed to evaluate the possible therapeutic potential of soymilk fermented by the riboflavin-producing strain Lactobacillus plantarum CRL 2130 in a trinitrobenzene sulfonic induced colitis mouse model...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27873165/analysing-the-effect-of-i1-imidazoline-receptor-ligands-on-dss-induced-acute-colitis-in-mice
#11
Ágnes Fehér, Viktória E Tóth, Mahmoud Al-Khrasani, Mihály Balogh, Bernadette Lázár, Zsuzsanna Helyes, Klára Gyires, Zoltán S Zádori
Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases; and moxonidine and rilmenidine, agonists of I1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha2-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis...
November 21, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27846836/regulatory-effects-of-glycyrrhizae-radix-extract-on-dss-induced-ulcerative-colitis
#12
Yong-Deok Jeon, Keuk-Soo Bang, Min-Kyoung Shin, Jong-Hyun Lee, Young-Nam Chang, Jong-Sik Jin
BACKGROUND: Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely-used in clinical health care. The clinical functions of GR include relief of toxicity, anti-cancer, regulating blood cholesterol and anti-inflammation. This study investigated the role of GR on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse model of colitis. METHOD: Western blot analysis and enzyme-linked immunosorbent assay (ELISA) analyses were done on male BALB/c mice administered 5 % DSS during the experimental period...
November 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27845570/anti-inflammatory-effect-of-novel-analogs-of-natural-enkephalinase-inhibitors-in-a-mouse-model-of-experimental-colitis
#13
Elżbieta Kamysz, Maciej Sałaga, Małgorzata Sobocińska, Artur Giełdoń, Jakub Fichna
AIM: The pharmacotherapy of inflammatory bowel disease is difficult and currently available treatments bring mostly poor and unsatisfactory results. RESULTS: The purpose of this work was the synthesis of opiorphin, sialorphin, spinorphin and a series of their analogs and the in vitro characterization of their effect on degradation of enkephalin by neutral endopeptidase and aminopeptidase N. Consequently, we investigated in vivo the anti-inflammatory effect of the most active inhibitors selected in the in vitro studies (Pal-KKQRFSR & Pal-KKQHNPR)...
November 15, 2016: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27843005/zanthoxylum-bungeanum-pericarp-extract-prevents-dextran-sulfate-sodium-induced-experimental-colitis-in-mice-via-the-regulation-of-tlr4-and-tlr4-related-signaling-pathways
#14
Zecai Zhang, Jiuxi Liu, Peng Shen, Yongguo Cao, Xiaojie Lu, Xuejiao Gao, Yunhe Fu, Bo Liu, Naisheng Zhang
Zanthoxylum bungeanum, which belongs to the Zanthoxylum genus of the Rutaceae family, is now wildly distributed in most parts of China and some Southeast Asian countries. The pericarp of Zanthoxylum bungeanum has been known to exhibit antibacterial, anti-inflammatory and other important therapeutic activities. The purpose of this study was to investigate the effects and mechanisms of Zanthoxylum bungeanum pericarp extract (ZBE) on DSS-induced experimental colitis in mice. The results demonstrated that the major flavonoid composition of ZBE includes rutin (32...
November 11, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27837558/menstrual-blood-derived-stem-cells-in-vitro-and-in-vivo-characterization-of-functional-effects
#15
Maria Carolina Oliveira Rodrigues, Trenton Lippert, Hung Nguyen, Sussannah Kaelber, Paul R Sanberg, Cesar V Borlongan
Accumulating evidence has demonstrated that menstrual blood stands as a viable source of stem cells. Menstrual blood-derived stem cells (MenSCs) are morphologically and functionally similar to cells directly extracted from the endometrium, and present dual expression of mesenchymal and embryonic cell markers, thus becoming interesting tools for regenerative medicine. Functional reports show higher proliferative and self-renewal capacities than bone marrow-derived stem cells, as well as successful differentiation into hepatocyte-like cells, glial-like cells, endometrial stroma-like cells, among others...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27837255/th9-cells-in-inflammatory-bowel-diseases
#16
REVIEW
Benno Weigmann, Markus F Neurath
Inflammatory bowel diseases are chronic, relapsing, immunologically mediated disorders of the gastrointestinal tract. Emerging evidence suggests a critical functional role of transcription factors and T cell-related cytokines in ulcerative colitis and Crohn's disease. Gut-residing T cells from patients with inflammatory bowel disease produce high amounts of IL-9. Experimental models of colitis highlighted that IL-9-producing T cells critically interfered with an intact barrier function of the intestinal epithelium by impacting cellular proliferation and tight junction molecules...
November 11, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27836928/the-common-mouse-protozoa-tritrichomonas-muris-alters-mucosal-t-cell-homeostasis-and-colitis-susceptibility
#17
Nichole K Escalante, Paul Lemire, Mayra Cruz Tleugabulova, David Prescott, Arthur Mortha, Catherine J Streutker, Stephen E Girardin, Dana J Philpott, Thierry Mallevaey
The mammalian gastrointestinal tract hosts a diverse community of microbes including bacteria, fungi, protozoa, helminths, and viruses. Through coevolution, mammals and these microbes have developed a symbiosis that is sustained through the host's continuous sensing of microbial factors and the generation of a tolerant or pro-inflammatory response. While analyzing T cell-driven colitis in nonlittermate mouse strains, we serendipitously identified that a nongenetic transmissible factor dramatically increased disease susceptibility...
November 11, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27833553/anti-inflammatory-effects-of-herbal-preparations-stw5-and-stw5-ii-in-cytokine-challenged-normal-human-colon-cells
#18
Mathias Schneider, Thomas Efferth, Heba Abdel-Aziz
Inflammatory bowel diseases (IBD) are chronic relapsing intestinal disorders characterized by up-regulation of pro-inflammatory cytokines followed by invasion of immune cells to the intestinal lamina propria. Standard therapies consist of anti-inflammatory or immunosuppressive drugs. Since clinical efficiency is not satisfactory and the established drugs have massive side effects, new strategies to treat IBD are required. Herein, we investigate the protective effect of the fixed combination herbal preparations STW5 and STW5-II and the contribution of the corresponding single components in an in vitro inflammation model...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27832441/comparative-effect-of-the-i3-1-probiotic-formula-in-two-animal-models-of-colitis
#19
Violeta Lorén, Josep Manyé, Mari C Fuentes, Eduard Cabré, Isabel Ojanguren, Jordi Espadaler
Use of probiotic therapy is an active area of investigation to treat intestinal disorders. The clinical benefits of the I3.1 probiotic formula (Lactobacillus plantarum (CECT7484, CECT7485) and P. acidilactici (CECT7483)) were demonstrated in irritable bowel syndrome (IBS) patients in a randomized, double-blind, placebo-controlled clinical trial. The aim of this study was to evaluate the therapeutic effects of I3.1 in two experimental models of colitis, a dextran sulfate sodium (DSS)-induced colitis model and an interleukin (IL)-10-deficient mice model...
November 10, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27819157/improvement-of-side-effects-and-treatment-on-the-experimental-colitis-in-mice-of-a-resin-microcapsule-loading-hydrocortisone-sodium-succinate
#20
Kai Dong, Hefeng Zhang, Yan Yan, Jinyao Sun, Yalin Dong, Ke Wang, Lu Zhang, Xianpeng Shi, Jianfeng Xing
CONTEXT: Extensive or long-time use of corticosteroids often causes many toxic side-effects. The ion exchange resins and the coating material, Eudragit, can be used in combination to form a new oral delivery system to deliver corticosteroids. OBJECTIVES: The resin microcapsule (DRM) composed by Amberlite 717 and Eudragit S100 was used to target hydrocortisone (HC) to the colon in order to improve its treatment effect on ulcerative colitis (UC) and reduce its toxic side-effects...
November 21, 2016: Drug Development and Industrial Pharmacy
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