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https://www.readbyqxmd.com/read/29331733/aronia-melanocarpa-fruit-juice-ameliorates-the-symptoms-of-inflammatory-bowel-disease-in-tnbs-induced-colitis-in-rats
#1
Stefka Valcheva-Kuzmanova, Atanas Kuzmanov, Vasilena Kuzmanova, Maria Tzaneva
Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29330048/b-cell-activation-in-the-cecal-patches-during-the-development-of-an-experimental-colitis-model
#2
Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe
Although previous studies have suggested that appendix seems to be involved in the colitis, the role of this in the pathogenesis remains unclear. In this study, we assessed the importance of appendiceal lymphoid follicles, specifically the cecal patches (CP) in mice, using an experimental colitis model. Treatment with oxazolone resulted in ulcerations particularly at CP with follicular expansion as well as colitis. The colitis was attenuated by either appendectomy or the absence of mature B cells. We therefore established an intravital imaging system accompanied by the fluorescence resonance energy transfer technology to analyze the dynamic immune response of CP B cells...
January 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29322404/in-vivo-models-of-inflammatory-bowel-disease-and-colitis-associated-cancer
#3
Ka Yee Fung, Tracy Putoczki
A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous complications including cancer. Here we describe three experimental protocols to chemically induce acute and chronic inflammatory bowel disease (IBD) symptoms and colitis-associated colorectal cancer (CRC) progression. These in vivo mouse models are based on the induction of damage to the colonic epithelium, resulting in an inflammatory and wound healing response...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29316822/beneficial-anti-inflammatory-effect-of-paeonol-self-microemulsion-loaded-colon-specific-capsules-on-experimental-ulcerative-colitis-rats
#4
Shiyu Zong, Yiqiong Pu, Suyun Li, Benliang Xu, Yong Zhang, Tong Zhang, Bing Wang
Paeonol, as the main phenolic compound isolated from the Chinese herbs, has been confirmed to present anti-inflammatory effects on ulcerative colitis (UC) in our previous study. However, its poor solubility has hindered its development of being a favourable pharmaceutical product in treating colon diseases. In this study, we prepared the colon-specific delivery system (Pae-SME-CSC) with paeonol-loaded self-microemulsion (Pae-SMEDDS), and evaluated its in vitro and in vivo properties, especially the anti-inflammatory effects on UC rats...
January 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29298798/phase-1-trial-of-m7824-msb0011359c-a-bifunctional-fusion-protein-targeting-pd-l1-and-tgf-%C3%AE-in-advanced-solid-tumors
#5
Julius Strauss, Christopher Heery, Jeffrey Schlom, Ravi A Madan, Liang Cao, Zhigang Kang, Elizabeth Lamping, Jennifer L Marte, Renee N Donahue, Italia Grenga, Lisa M Cordes, Olaf Christensen, Lisa Mahnke, Christoph Helwig, James L Gulley
PURPOSE: M7824 (MSB0011359C) is an innovative first-in-class bifunctional fusion protein composed of a monoclonal antibody against programmed death ligand 1 (PD-L1) fused to a transforming growth factor-β (TGF-β) "trap." Experimental DesignIn the 3+3 dose-escalation component of this phase 1 study (NCT02517398), eligible patients with advanced solid tumors received M7824 at 1, 3, 10, or 20 mg/kg once-every-2-weeks until confirmed progression, unacceptable toxicity, or trial withdrawal; additionally, a cohort received an initial 0...
January 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29288684/the-octapetide-nap-alleviates-intestinal-and-extra-intestinal-anti-inflammatory-sequelae-of-acute-experimental-colitis
#6
Markus M Heimesaat, Eliezer Giladi, Anja A Kühl, Stefan Bereswill, Illana Gozes
The octapeptide NAP has been shown to exert neuroprotective properties and reduce neuro-inflammatory responses. The aim of the present study was to investigate if NAP provides anti-inflammatory effects in acute murine colitis. To address this, C57BL/6 j mice were challenged with 3.5% dextran sulfate sodium from day 0 until day 6 to induce colitis, either treated intraperitoneally with NAP or placebo (NaCl 0.9%) from day 1 until day 6 post-induction (p.i.) and subjected to in depth macroscopic, microscopic and immunological evaluations...
December 27, 2017: Peptides
https://www.readbyqxmd.com/read/29286109/the-protective-effects-of-magnolol-on-acute-trinitrobenzene-sulfonic-acid%C3%A2-induced-colitis-in-rats
#7
Yong Zhang, Li-Tang Fu, Fang Tang
The present study aimed to investigate the protective effects of magnolol on acute 2,4,6-trinitrobenzene sulfonic acid (TNBS)‑induced colitis, and its underlying mechanisms. Experimental colitis was induced by intracolonic administration of TNBS/ethanol into rats. The model rats were randomly assigned into groups: TNBS, magnolol (high, medium and low doses), and salazosulfapyridine (positive control). All intervention regimens were administered by oral gavage, once a day for 7 consecutive days, 24 h after colitis induction...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29285689/gut-microbiota-in-the-pathogenesis-of-inflammatory-bowel-disease
#8
REVIEW
Atsushi Nishida, Ryo Inoue, Osamu Inatomi, Shigeki Bamba, Yuji Naito, Akira Andoh
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic and relapsing inflammatory disorder of the intestine. Although its incidence is increasing globally, the precise etiology remains unclear and a cure for IBD has yet to be discovered. The most accepted hypothesis of IBD pathogenesis is that complex interactions between genetics, environmental factors, and the host immune system lead to aberrant immune responses and chronic intestinal inflammation. The human gut harbors a complex and abundant aggregation of microbes, collectively referred to as the gut microbiota...
December 29, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29285167/effectiveness-of-c5a-aptamers-in-a-tnbs-induced-colitis-mouse-model
#9
Zhiping Li, Xiwen Wang, Man Chen, Yuanyuan Wang, Rui Sun, Han Qu, Yu Sun, Weicun Gao, Bo Li, Xiaolin Dong, Yandong Zhang, Zhiping Xia
The complement-activated product, complement component 5a (C5a), is a potent inflammatory peptide with a broad spectrum of functions. In vivo and in vitro studies have demonstrated that C5a serves an important role in inflammation; however, the role of C5a in the pathogenesis of inflammatory bowel disease (IBD) is not known. The purpose of the current study was to investigate the role of C5a in IBD using an experimental mouse model of colitis. Colitis was induced in mice using 2,4,6-trinitrobenzene sulfonic acid (TNBS), and C5a aptamers were subsequently administered via intraperitoneal injection...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29285080/orally-administered-sodium-4-phenylbutyrate-suppresses-the-development-of-dextran-sulfate-sodium-induced-colitis-in-mice
#10
Kazuhiko Ono, Satoshi Nimura, Yuko Hideshima, Kazuki Nabeshima, Manabu Nakashima
Sodium 4-phenylbutyrate (PBA) exerts therapeutic effects in a wide range of pathologies. A previous study by the present authors revealed that intraperitoneal administration of PBA suppresses the onset of dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, the effects of orally administered PBA are investigated, as this route of administration is more clinically relevant. The therapeutic efficacy of PBA (10 mg/12 h) in mice with experimental colitis was assessed based on the disease activity index, production of inflammatory cytokines, colon length and histopathological investigations...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29282051/microbiota-dysbiosis-in-inflammatory-bowel-diseases-in-silico-investigation-of-the-oxygen-hypothesis
#11
Michael A Henson, Poonam Phalak
BACKGROUND: Inflammatory bowel diseases (IBD), which include ulcerative colitis and Crohn's disease, cause chronic inflammation of the digestive tract in approximately 1.6 million Americans. A signature of IBD is dysbiosis of the gut microbiota marked by a significant reduction of obligate anaerobes and a sharp increase in facultative anaerobes. Numerous experimental studies have shown that IBD is strongly correlated with a decrease of Faecalibacterium prausnitzii and an increase of Escherichia coli...
December 28, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29278445/the-effect-of-7-hydroxycoumarin-on-dextran-sulfate-sodium-induced-ulcerative-colitis
#12
Chengzheng Wang, Jing Liu, Yingchun Zhou, Gao Feng
7-Hydroxycoumarin (HC) or Umbelliferone exerts many beneficial effects, ie. antioxidant, anti-tumour, anti-inflammatory and immunomodulatory activities. We hypothesized that HC had mitigating properties on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in mice, via suppression of inflammation. The induction of UC in mice was achieved by the administration of 3.5% DSS in drinking water for 7 consecutive days. Administration of HC to DSS-induced mice ameliorated the loss of body weight, reduced diarrhoea and gross bleeding and showed a significant reduction in the disease activity index (DAI)...
December 26, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29261815/knockdown-of-myeloid-cell-hypoxia-inducible-factor-1%C3%AE-ameliorates-the-acute-pathology-in-dss-induced-colitis
#13
Veronika Bäcker, Fung-Yi Cheung, Jens T Siveke, Joachim Fandrey, Sandra Winning
Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible factors control immune cell function and survival. Still, the role of myeloid hypoxia-inducible factor-1 during inflammatory bowel disease remains poorly defined. We therefore investigated the role of hypoxia-inducible factor-1 for myeloid cell function and immune response during colitis...
2017: PloS One
https://www.readbyqxmd.com/read/29249635/study-on-physical-properties-of-ayurvedic-nanocrystalline-tamra-bhasma-by-employing-modern-scientific-tools
#14
Rakesh Kr Singh, Sanjay Kumar, Abhay Kr Aman, S M Karim, Sunil Kumar, Manoranjan Kar
BACKGROUND: Tamra Bhasma is derived from metallic copper that is recommended for different ailments of liver and spleen, dropsy, abdominal pain, heart disease, colitis, tumors, anemia, loss of appetite, tuberculosis, as well as eye problems. OBJECTIVES: The knowledge of crystallite size and active ingredients in Bhasma materials is limited restricting its use as nanomedicine in the modern era. Also, the 2015 Nobel prize in medicine has motivated many researchers towards traditional medicines...
December 15, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29247987/suppression-of-inflammation-and-acquired-immunity-by-il-37
#15
REVIEW
Giulio Cavalli, Charles A Dinarello
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes. Both precursor and mature IL-37 are also secreted in the extracellular space, where they bind IL-18Rα and recruit the IL-1R8 (formerly TIR8 or SIGIRR), which transduces anti-inflammatory signals by suppressing NF-kB and MAPK and by activating Mer-PTEN-DOK pathways...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29247612/intestinal-alkaline-phosphatase-ameliorates-experimental-colitis-via-toll-like-receptor-4-dependent-pathway
#16
Sung Wook Hwang, Jee Hyun Kim, Changhyun Lee, Jong Pil Im, Joo Sung Kim
Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme which plays an important role in gut homeostasis and mucosal inflammation. However, the mechanism of the protective effect of IAP is not fully elucidated. The aim of the present study was to evaluate whether the protective effect of IAP on colitis is mediated via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway. For in vitro analysis, peritoneal macrophages from the wild-type (WT) and TLR4-deficient (TLR4-/-) C57BL/6 mice were used...
December 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29247178/changes-in-hyaluronan-deposition-in-the-rat-myenteric-plexus-after-experimentally-induced-colitis
#17
Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti
Myenteric plexus alterations hamper gastrointestinal motor function during intestinal inflammation. Hyaluronan (HA), an extracellular matrix glycosaminoglycan involved in inflammatory responses, may play a role in this process. In the colon of control rats, HA-binding protein (HABP), was detected in myenteric neuron soma, perineuronal space and ganglia surfaces. Prominent hyaluronan synthase 2 (HAS2) staining was found in myenteric neuron cytoplasm, suggesting that myenteric neurons produce HA. In the myenteric plexus of rats with 2, 4-dinitrobenzene sulfonic (DNBS)-induced colitis HABP staining was altered in the perineuronal space, while both HABP staining and HA levels increased in the muscularis propria...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246278/maillard-reaction-products-from-highly-heated-food-prevent-mast-cell-number-increase-and-inflammation-in-a-mouse-model-of-colitis
#18
Issam Al Amir, David Dubayle, Anne Héron, Carine Delayre-Orthez, Pauline M Anton
Links between food and inflammatory bowel diseases (IBDs) are often suggested, but the role of food processing has not been extensively studied. Heat treatment is known to cause the loss of nutrients and the appearance of neoformed compounds such as Maillard reaction products. Their involvement in gut inflammation is equivocal, as some may have proinflammatory effects, whereas other seem to be protective. As IBDs are associated with the recruitment of immune cells, including mast cells, we raised the hypothesis that dietary Maillard reaction products generated through heat treatment of food may limit the colitic response and its associated recruitment of mast cells...
December 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241308/infusion-of-porcine-derived-amniotic-fluid-stem-cells-for-treatment-of-experimental-colitis-in-mice
#19
Kun-Yi Lin, Shao-Yu Peng, Chih-Jen Chou, Herng-Sheng Lee, Leou-Chyr Lin, Ru-Yu Pan, Shinn-Chih Wu
Recently, stem cells have offered an alternative treatment for inflammatory bowel disease or colitis to overcome the poor outcomes associated with current therapies. Amniotic fluid-derived stem cells have the potential for the regeneration of impaired organs and the recovery of normal physiologic functions of damaged tissues without ethical concerns or risk of tumor formation. In this work, we aimed to examine the therapeutic effects of infusion of porcine amniotic fluid-derived stem cells (pAFSCs) in dextran sulfate sodium (DSS)-induced colitis in mice...
December 15, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29235493/small-molecules-related-to-adrenomedullin-reduce-tumor-burden-in-a-mouse-model-of-colitis-associated-colon-cancer
#20
Laura Ochoa-Callejero, Josune García-Sanmartín, Sonia Martínez-Herrero, Susana Rubio-Mediavilla, Judit Narro-Íñiguez, Alfredo Martínez
To investigate the contribution of adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), to the progression and potential treatment of colon cancer we studied the effects of four small molecules (SM) related to AM and PAMP on a mouse model of colon cancer. For each SM, four experimental groups of male mice were used: (i) Control group; (ii) SM group; (iii) DSS group (injected with azoxymethane [AOM] and drank dextran sulfate sodium [DSS]); and (iv) DSS + SM group (treated with AOM, DSS, and the SM)...
December 13, 2017: Scientific Reports
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