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Gregory J Landry, Courtney J Mostul, Daniel S Ahn, Bryant J McLafferty, Timothy K Liem, Erica L Mitchell, Enjae Jung, Cherrie Z Abraham, Amir F Azarbal, Robert B McLafferty, Gregory L Moneta
OBJECTIVE: Vascular surgeons may be consulted to evaluate hospitalized patients with finger ischemia. We sought to characterize causes and outcomes of finger ischemia in intensive care unit (ICU) patients. METHODS: All ICU patients who underwent evaluation for finger ischemia from 2008 to 2015 were reviewed. All were evaluated with finger photoplethysmography. The patients' demographics, comorbidities, ICU care (ventilator status, arterial lines, use of vasoactive medications), finger amputations, and survival were also recorded...
April 20, 2018: Journal of Vascular Surgery
Toshiya Kojima, Katsuhito Fujiu, Nobuaki Fukuma, Hiroshi Matsunaga, Tsukasa Oshima, Jun Matsuda, Takumi Matsubara, Yu Shimizu, Gaku Oguri, Eriko Hasumi, Hiroyuki Morita, Issei Komuro
BACKGROUND: Periprocedural anticoagulation is important in catheter ablation (CA) of atrial fibrillation (AF) and there is increasing evidence that uninterrupted vitamin K antagonist (VKA) therapy is superior to interrupted anticoagulation strategies. Since the emergence of direct oral anticoagulants (DOACs), numerous studies have shown promising results for their use in uninterrupted strategies. However, further studies are needed to further define the efficacy and safety of performing AF ablation with uninterrupted factor XA inhibitors or direct thrombin inhibitors...
April 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
B Kováčová, J Červeňová
Direct oral anticoagulants (DOACs) became rapidly accepted as an alternative to warfarin in the prevention of stroke in atrial fibrillation and prophylaxis of thromboembolic events. Their safety and efficacy have been well documented in several studies, however, as with any new drug, use in real-world population often reveals risk factors that may affect treatment outcomes. The aim of the study was to determine the prescribing patterns and analyse patient characteristics to identify incidence of selected factors (age, weight, comorbidities and interacting medication) that may affect DOAC safety and efficacy...
September 1, 2017: Die Pharmazie
Ana B Arroyo, Ascensión M de Los Reyes-García, José M Rivera-Caravaca, Patricia Valledor, Nuria García-Barberá, Vanessa Roldán, Vicente Vicente, Constantino Martínez, Rocío González-Conejero
OBJECTIVE: Atrial fibrillation (AF) patients experience adverse cardiovascular events (ACEs) despite anticoagulant therapy. We reported that rs2431697 of miR-146a, a negative regulator of inflammation, predicts ACEs in patients with AF. The relationship between neutrophil extracellular traps and thrombogenesis is known. Thus, our aim was to evaluate the role of neutrophil extracellular trap compounds as prognostic markers of ACEs in AF and to study whether miR-146a affects NETosis. APPROACH AND RESULTS: We included 336 steadily anticoagulated AF patients with a median follow-up of 7...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Stanislas Faguer, Morgane Saint-Cricq, Marie-Béatrice Nogier, Isabelle Labadens, Laurence Lavayssiere, Nassim Kamar, Olivier Cointault
OBJECTIVES: Critically ill patients who have a high risk of bleeding but require prolonged intermittent dialysis need a heparin-free easy-to-use alternative type of anticoagulation within the dialysis circuit. We assessed the safety and efficiency of heparin-free regional citrate anticoagulation of the dialysis circuit using a calcium-free citrate-containing dialysate, with calcium reinjected according to ionic dialysance. DESIGN: Prospective cohort study. SETTING: Critical care units...
November 2017: Critical Care Medicine
Michael Boettcher, Dennis Meier, Miguel Jiménez-Alcázar, Georg Eschenburg, Stefan Mietzsch, Deirdre Vincent, Michaela Klinke, Magdalena Trochimiuk, Birgit Appl, Bastian Tiemann, Robert Bergholz, Konrad Reinshagen, Tobias A Fuchs
OBJECTIVE: To examine the effects of DNase1 treatment on testicular damage after testicular torsion (TT). It has been demonstrated that TT induces thrombus formation and that anticoagulation significantly reduces testicular damage after TT. It was hypothesized that these thrombi are dependent on neutrophil extracellular traps (NETs) and thus NETs disintegration would reduce testicular cell damage. METHODS: A sham operation was performed in 10 rats. Thirty-four rats underwent induction of iatrogenic TT for 3 hours...
November 2017: Urology
M M Tawfik, M E Taman, A I Tarbay, M Sayed, K A Awad
Embolic events including thromboembolism, air embolism, and amniotic fluid embolism can cause cardiovascular collapse during cesarean delivery. Differentiation between the three conditions is challenging because they share many of the initial clinical and echocardiographic findings, but an accurate, definitive diagnosis allows the administration of specific therapy that may help in saving the life of the mother and/or the fetus. We report a case of cardiovascular collapse during cesarean delivery under general anesthesia; massive pulmonary thromboembolism was suspected and unfractionated heparin was administered...
May 2017: International Journal of Obstetric Anesthesia
Norberto Ruiz-Suárez, Yolanda Melero, Anna Giela, Luis A Henríquez-Hernández, Elizabeth Sharp, Luis D Boada, Michael J Taylor, María Camacho, Xavier Lambin, Octavio P Luzardo, Gill Hartley
Anticoagulant rodenticides (ARs) are highly toxic compounds that are exclusively used for the control of rodent pests. Despite their defined use, they are nonetheless found in a large number of non-target species indicating widespread penetration of wildlife. Attempts to quantify the scale of problem are complicated by non-random sampling of individuals tested for AR contamination. The American mink (Neovison vison) is a wide ranging, non-native, generalist predator that is subject to wide scale control efforts in the UK...
November 1, 2016: Science of the Total Environment
Mais Ali-Saleh, Galit Sarig, Jacob N Ablin, Benjamin Brenner, Giris Jacob
BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of β2-adrenorecptors (β2AR). Accordingly, we tested the hypothesis that inhalation of a short-acting selective β2AR agonist can induce a procoagulant state in healthy individuals. METHODS: We recruited 23 healthy volunteers (nine females; mean age: 26±0.8 years; body mass index: 24.7±0.5 kg/m2) and randomly allocated them into two groups, the β2AR arm (seventeen subjects) and the saline arm (six subjects)...
2016: PloS One
Agata Schlesinger, Avraham Weiss, Olga Nenaydenko, Abraham Adunsky, Yichayaou Beloosesky
OBJECTIVES: To investigate the association between polypharmacy and mortality in nursing home (NH) residents. DESIGN: Prospective observational cohort study. SETTINGS: Six NHs in central Israel. PARTICIPANTS: Mobile with dementia and fully dependent residents (N = 764; n = 558 (73%) fully dependent, n = 206 (27%) mobile residents with dementia requiring institutional care; mean age 82.2 ± 5.9). MEASUREMENTS: Two-year mortality and its association with number of drugs that individual residents were taking at baseline, controlled for multiple confounders...
July 2016: Journal of the American Geriatrics Society
N Janus, V Launay-Vacher, B Aloy, G Deray
OBJECTIFS: L'insuffisance rénale (IR) est fréquente en cardiologie, notamment chez les patients ayant une fibrillation atriale (FA), ainsi que chez les patients ayant une maladie thromboembolique veineuse. De plus, l'IR est un facteur de risque de mortalité chez les patients ayant une FA. Ainsi, la question du maniement des médicaments et plus particulièrement des anticoagulants oraux directs (AOD), est de plus en plus fréquente. L'objectif de cette revue de la littérature réalisé par le Service ICAR est de faire le point de sur les adaptations posologiques chez le patient IR...
December 2015: Annales de Cardiologie et D'angéiologie
M Khadhar, H Jebali, M Najjar, R Kheder, L Raïs, L Ben Fatma, W Smaoui, M Krid, F Ben Moussa, S Beji, K Zouaghi
OBJECTIFS: L'atteinte cardiaque est fréquente au cours du lupus érythémateux systémique (LES), et peut concerner le tissu péricardique, myocardique, valvulaire ou les artères coronaires. En effet, le cœur est touché dans 15 % à 82 % des cas et représente l'une des plus grandes causes de mortalité. MéTHODES: Étude rétrospective et descriptive portant sur les dossiers de patients hospitalisés au Service de Néphrologie de l'Hôpital la Rabta, entre 2007 et 2015 pour LES (retenu sur au moins 4 critères sur 11 de l'ACR)...
December 2015: Annales de Cardiologie et D'angéiologie
Xuan Dang, Jing-Jing Miao, An-Qi Chen, Peng Li, Lin Chen, Jin-Ru Liang, Ren-Ming Xie, Ye Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Reduction of Sheng-Nao-Kang decoction (RSNK), composed of Salvia miltiorrhiza Bge., Ligusticum chuanxiong Hort., Astragalus membranaceus (Fisch.) Bunge., Pueraria lobata (Willd.) Ohwi., Paeonia lactiflora Pall. and Panax notoginseng (Burk.) F. H. Chen., is a modified traditional Chinese medicinal formula of Sheng-Nao-Kang pill preparation, which has been investigated its protective effect on focal cerebral ischemia-reperfusion injury in rat in our previous report...
September 15, 2015: Journal of Ethnopharmacology
Laszlo Mark, Győző Dani, Robert Vendrey, György Paragh, Andras Katona
BACKGROUND: Vitamin K antagonists, despite their tight therapeutic spectrum and the fear of bleeding complications, were long the most important drugs used in anticoagulant therapy. The aim of this study was to evaluate the quality of anticoagulant therapy and its relation with bleedings in everyday clinical practice. MATERIAL AND METHODS: We analyzed the data of 272 patients with non-valvular atrial fibrillation treated in our county hospital using retrospective data collection of the last 1008±384 days...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ariela Hoxha, Amelia Ruffatti, Elena Mattia, Lauro Meneghel, Marta Tonello, Elisa Salvan, Vittorio Pengo, Leonardo Punzi
BACKGROUND: Antiphosphatidylserine/prothrombin complex (aPS/PT) antibodies are emerging as an important marker for antiphospholipid syndrome (APS). We aimed to compare their performance with that of conventional antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) in APS and to assess their frequency in APS-negative (APS-ne) patients. METHODS: We considered 160 APS patients and 128 APS-ne patients with clinical criteria for APS but tested negative for conventional aPL...
July 2015: Clinical Chemistry and Laboratory Medicine: CCLM
Jhon J López-Perea, Pablo R Camarero, Rafael A Molina-López, Luis Parpal, Elena Obón, Jessica Solá, Rafael Mateo
We studied the prevalence of anticoagulant rodenticides (ARs) in the liver of 344 individuals representing 11 species of predatory wildlife that were found dead in the Mediterranean region of Spain (Catalonia and Majorca Island). Six different ARs (brodifacoum, bromadiolone, difenacoum, flocoumafen, difethialone, warfarin) were found in the liver of 216 (62.8%) animals and >1 AR co-occurred in 119 individuals (34.6%). The occurrence of ARs was positively correlated with the human population density. Catalonia and Majorca showed similar prevalence of AR detection (64...
April 1, 2015: Science of the Total Environment
Saba Motakef, Paschalia M Mountziaris, Inzhili K Ismail, Richard L Agag, Ashit Patel
BACKGROUND: Microsurgical free tissue transfer has become an increasingly valuable technique in reconstructive surgery. However, there is a paucity of evidence-based guidelines to direct management. A systematic review was performed to define strategies to optimize perioperative management. METHODS: A systematic review of the literature was performed using key search terms. Strategies to guide patient management were identified, classified according to level of evidence, and used to devise recommendations in seven categories: patient temperature, anesthesia, fluid administration/blood transfusion, vasodilators, vasopressors, and anticoagulation...
January 2015: Plastic and Reconstructive Surgery
H O Eliwan, R W G Watson, S Aslam, I Regan, B Philbin, F M O'Hare, A O'Neill, R Preston, A Blanco, T Grant, B Nolan, O Smith, E J Molloy
Infection and inflammation can be antecedents of neonatal encephalopathy (NE) and increase the risk of neurological sequelae. Activated protein C (APC) has anti-coagulant and anti-inflammatory effects and provides neuroprotection in brain and spinal cord injury. We examined neutrophil and monocyte responses to lipopolysaccharide (LPS) in infants with NE compared with healthy adult and neonatal controls, and also studied the effect of APC. Whole blood was incubated with LPS and APC and Toll-like receptor (TLR)-4 (LPS recognition), CD11b expression (activation) and intracellular reactive oxygen intermediate (ROI; function) release from neutrophils and monocytes was examined by flow cytometry serially from days 1 to 7...
March 2015: Clinical and Experimental Immunology
Shahram Ghanaati, Patrick Booms, Anna Orlowska, Alica Kubesch, Jonas Lorenz, Jim Rutkowski, Constantin Landes, Robert Sader, Cj Kirkpatrick, Joseph Choukroun
Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants. In this study, protocols for standard platelet-rich fibrin (S-PRF) (2700 rpm, 12 minutes) and advanced platelet-rich fibrin (A-PRF) (1500 rpm, 14 minutes) were compared to establish by histological cell detection and histomorphometrical measurement of cell distribution the effects of the centrifugal force (speed and time) on the distribution of cells relevant for wound healing and tissue regeneration. Immunohistochemistry for monocytes, T and B -lymphocytes, neutrophilic granulocytes, CD34-positive stem cells, and platelets was performed on clots produced from four different human donors...
December 2014: Journal of Oral Implantology
Bryan A Whitson, Peter Eckman, Forum Kamdar, Alexandra Lacey, Sara J Shumway, Kenneth K Liao, Ranjit John
BACKGROUND: An ongoing challenge in the management of patients with heart failure who receive left ventricular assist devices (LVADs) is achieving optimal anticoagulation. Adverse prothrombotic events include hemolysis or pump thrombus (H/T) and neurologic events (NEs), and all limit the success of LVAD therapy. Our aim was to study the incidence and clinical outcomes associated with these events in a large single-center cohort. METHODS: We retrospectively reviewed our prospectively collected database of all patients receiving a HeartMate II (Thoratec Corp, Pleasanton, CA) LVAD from 2005 to 2012...
June 2014: Annals of Thoracic Surgery
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