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ne anticoagulant

Norberto Ruiz-Suárez, Yolanda Melero, Anna Giela, Luis A Henríquez-Hernández, Elizabeth Sharp, Luis D Boada, Michael J Taylor, María Camacho, Xavier Lambin, Octavio P Luzardo, Gill Hartley
Anticoagulant rodenticides (ARs) are highly toxic compounds that are exclusively used for the control of rodent pests. Despite their defined use, they are nonetheless found in a large number of non-target species indicating widespread penetration of wildlife. Attempts to quantify the scale of problem are complicated by non-random sampling of individuals tested for AR contamination. The American mink (Neovison vison) is a wide ranging, non-native, generalist predator that is subject to wide scale control efforts in the UK...
November 1, 2016: Science of the Total Environment
Mais Ali-Saleh, Galit Sarig, Jacob N Ablin, Benjamin Brenner, Giris Jacob
BACKGROUND: Catecholamine infusion elicits an increase in clotting factors and this increase has been attributed to stimulation of β2-adrenorecptors (β2AR). Accordingly, we tested the hypothesis that inhalation of a short-acting selective β2AR agonist can induce a procoagulant state in healthy individuals. METHODS: We recruited 23 healthy volunteers (nine females; mean age: 26±0.8 years; body mass index: 24.7±0.5 kg/m2) and randomly allocated them into two groups, the β2AR arm (seventeen subjects) and the saline arm (six subjects)...
2016: PloS One
Agata Schlesinger, Avraham Weiss, Olga Nenaydenko, Abraham Adunsky, Yichayaou Beloosesky
OBJECTIVES: To investigate the association between polypharmacy and mortality in nursing home (NH) residents. DESIGN: Prospective observational cohort study. SETTINGS: Six NHs in central Israel. PARTICIPANTS: Mobile with dementia and fully dependent residents (N = 764; n = 558 (73%) fully dependent, n = 206 (27%) mobile residents with dementia requiring institutional care; mean age 82.2 ± 5.9). MEASUREMENTS: Two-year mortality and its association with number of drugs that individual residents were taking at baseline, controlled for multiple confounders...
July 2016: Journal of the American Geriatrics Society
N Janus, V Launay-Vacher, B Aloy, G Deray
OBJECTIFS: L'insuffisance rénale (IR) est fréquente en cardiologie, notamment chez les patients ayant une fibrillation atriale (FA), ainsi que chez les patients ayant une maladie thromboembolique veineuse. De plus, l'IR est un facteur de risque de mortalité chez les patients ayant une FA. Ainsi, la question du maniement des médicaments et plus particulièrement des anticoagulants oraux directs (AOD), est de plus en plus fréquente. L'objectif de cette revue de la littérature réalisé par le Service ICAR est de faire le point de sur les adaptations posologiques chez le patient IR...
December 2015: Annales de Cardiologie et D'angéiologie
M Khadhar, H Jebali, M Najjar, R Kheder, L Raïs, L Ben Fatma, W Smaoui, M Krid, F Ben Moussa, S Beji, K Zouaghi
OBJECTIFS: L'atteinte cardiaque est fréquente au cours du lupus érythémateux systémique (LES), et peut concerner le tissu péricardique, myocardique, valvulaire ou les artères coronaires. En effet, le cœur est touché dans 15 % à 82 % des cas et représente l'une des plus grandes causes de mortalité. MéTHODES: Étude rétrospective et descriptive portant sur les dossiers de patients hospitalisés au Service de Néphrologie de l'Hôpital la Rabta, entre 2007 et 2015 pour LES (retenu sur au moins 4 critères sur 11 de l'ACR)...
December 2015: Annales de Cardiologie et D'angéiologie
Xuan Dang, Jing-Jing Miao, An-Qi Chen, Peng Li, Lin Chen, Jin-Ru Liang, Ren-Ming Xie, Ye Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Reduction of Sheng-Nao-Kang decoction (RSNK), composed of Salvia miltiorrhiza Bge., Ligusticum chuanxiong Hort., Astragalus membranaceus (Fisch.) Bunge., Pueraria lobata (Willd.) Ohwi., Paeonia lactiflora Pall. and Panax notoginseng (Burk.) F. H. Chen., is a modified traditional Chinese medicinal formula of Sheng-Nao-Kang pill preparation, which has been investigated its protective effect on focal cerebral ischemia-reperfusion injury in rat in our previous report...
September 15, 2015: Journal of Ethnopharmacology
Laszlo Mark, Győző Dani, Robert Vendrey, György Paragh, Andras Katona
BACKGROUND: Vitamin K antagonists, despite their tight therapeutic spectrum and the fear of bleeding complications, were long the most important drugs used in anticoagulant therapy. The aim of this study was to evaluate the quality of anticoagulant therapy and its relation with bleedings in everyday clinical practice. MATERIAL AND METHODS: We analyzed the data of 272 patients with non-valvular atrial fibrillation treated in our county hospital using retrospective data collection of the last 1008±384 days...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ariela Hoxha, Amelia Ruffatti, Elena Mattia, Lauro Meneghel, Marta Tonello, Elisa Salvan, Vittorio Pengo, Leonardo Punzi
BACKGROUND: Antiphosphatidylserine/prothrombin complex (aPS/PT) antibodies are emerging as an important marker for antiphospholipid syndrome (APS). We aimed to compare their performance with that of conventional antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) in APS and to assess their frequency in APS-negative (APS-ne) patients. METHODS: We considered 160 APS patients and 128 APS-ne patients with clinical criteria for APS but tested negative for conventional aPL...
July 2015: Clinical Chemistry and Laboratory Medicine: CCLM
Jhon J López-Perea, Pablo R Camarero, Rafael A Molina-López, Luis Parpal, Elena Obón, Jessica Solá, Rafael Mateo
We studied the prevalence of anticoagulant rodenticides (ARs) in the liver of 344 individuals representing 11 species of predatory wildlife that were found dead in the Mediterranean region of Spain (Catalonia and Majorca Island). Six different ARs (brodifacoum, bromadiolone, difenacoum, flocoumafen, difethialone, warfarin) were found in the liver of 216 (62.8%) animals and >1 AR co-occurred in 119 individuals (34.6%). The occurrence of ARs was positively correlated with the human population density. Catalonia and Majorca showed similar prevalence of AR detection (64...
April 1, 2015: Science of the Total Environment
Saba Motakef, Paschalia M Mountziaris, Inzhili K Ismail, Richard L Agag, Ashit Patel
BACKGROUND: Microsurgical free tissue transfer has become an increasingly valuable technique in reconstructive surgery. However, there is a paucity of evidence-based guidelines to direct management. A systematic review was performed to define strategies to optimize perioperative management. METHODS: A systematic review of the literature was performed using key search terms. Strategies to guide patient management were identified, classified according to level of evidence, and used to devise recommendations in seven categories: patient temperature, anesthesia, fluid administration/blood transfusion, vasodilators, vasopressors, and anticoagulation...
January 2015: Plastic and Reconstructive Surgery
H O Eliwan, R W G Watson, S Aslam, I Regan, B Philbin, F M O'Hare, A O'Neill, R Preston, A Blanco, T Grant, B Nolan, O Smith, E J Molloy
Infection and inflammation can be antecedents of neonatal encephalopathy (NE) and increase the risk of neurological sequelae. Activated protein C (APC) has anti-coagulant and anti-inflammatory effects and provides neuroprotection in brain and spinal cord injury. We examined neutrophil and monocyte responses to lipopolysaccharide (LPS) in infants with NE compared with healthy adult and neonatal controls, and also studied the effect of APC. Whole blood was incubated with LPS and APC and Toll-like receptor (TLR)-4 (LPS recognition), CD11b expression (activation) and intracellular reactive oxygen intermediate (ROI; function) release from neutrophils and monocytes was examined by flow cytometry serially from days 1 to 7...
March 2015: Clinical and Experimental Immunology
Shahram Ghanaati, Patrick Booms, Anna Orlowska, Alica Kubesch, Jonas Lorenz, Jim Rutkowski, Constantin Landes, Robert Sader, Cj Kirkpatrick, Joseph Choukroun
Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants. In this study, protocols for standard platelet-rich fibrin (S-PRF) (2700 rpm, 12 minutes) and advanced platelet-rich fibrin (A-PRF) (1500 rpm, 14 minutes) were compared to establish by histological cell detection and histomorphometrical measurement of cell distribution the effects of the centrifugal force (speed and time) on the distribution of cells relevant for wound healing and tissue regeneration. Immunohistochemistry for monocytes, T and B -lymphocytes, neutrophilic granulocytes, CD34-positive stem cells, and platelets was performed on clots produced from four different human donors...
December 2014: Journal of Oral Implantology
Bryan A Whitson, Peter Eckman, Forum Kamdar, Alexandra Lacey, Sara J Shumway, Kenneth K Liao, Ranjit John
BACKGROUND: An ongoing challenge in the management of patients with heart failure who receive left ventricular assist devices (LVADs) is achieving optimal anticoagulation. Adverse prothrombotic events include hemolysis or pump thrombus (H/T) and neurologic events (NEs), and all limit the success of LVAD therapy. Our aim was to study the incidence and clinical outcomes associated with these events in a large single-center cohort. METHODS: We retrospectively reviewed our prospectively collected database of all patients receiving a HeartMate II (Thoratec Corp, Pleasanton, CA) LVAD from 2005 to 2012...
June 2014: Annals of Thoracic Surgery
E Tan, A C G Abrams-Ogg, A Defarges, D Bienzle
Automated analysis of bone marrow (BM) aspirates is a useful 'pre-microscopical' screen to identify hypocellular samples and those with potentially abnormal cells. In order to determine whether automated analysis could also be used to identify haemopoietic abnormalities, EDTA-anticoagulated BM aspirates from 43 dogs were analysed using the Advia 2120 instrument. Corresponding Wright-stained BM smears were evaluated microscopically to determine smear quality, cell composition and 500-cell differential counts, and correlation to automated analysis parameters was computed...
July 2014: Journal of Comparative Pathology
Pär I Johansson, Nicolai Haase, Anders Perner, Sisse R Ostrowski
PURPOSE: The purpose of this study is to investigate potential associations between sympathoadrenal activation and/or vasopressor/inotropic therapy and endothelial activation, damage, and coagulopathy in septic patients. MATERIALS AND METHODS: Septic patients included in the Scandinavian Starch for Severe Sepsis/Septic Shock trial who were expected not to receive catecholamines at screening preintervention (baseline) and had baseline blood sampled. Clinical, outcome data, and measurements of plasma concentration (p-) biomarkers reflecting sympathoadrenal activation, endothelial activation and damage, natural anticoagulation, fibrinolysis, cell damage, and platelet activation...
June 2014: Journal of Critical Care
Pekka Löppönen, Sami Tetri, Seppo Juvela, Juha Huhtakangas, Pertti Saloheimo, Michaela K Bode, Matti Hillbom
OBJECT: Patients receiving oral anticoagulants run a higher risk of cerebral hemorrhage with a poor outcome. Serotonin-modulating antidepressants (selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs]) are frequently used in combination with warfarin, but it is unclear whether this combination of drugs influences outcome after primary intracerebral hemorrhage (PICH). The authors investigated case fatality in PICH among patients from a defined population who were receiving warfarin alone, with aspirin, or with serotonin-modulating antidepressants...
June 2014: Journal of Neurosurgery
Kathryn L Griffin, Bernard M Fischer, Apparao B Kummarapurugu, Shuo Zheng, Thomas P Kennedy, Narayanam V Rao, W Michael Foster, Judith A Voynow
Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. Despite its key role in the pathogenesis of CF lung disease, there are currently no effective antiprotease therapies available to patients with CF. Although heparin is an effective antiprotease and anti-inflammatory agent, its anticoagulant activity prohibits its use in CF, due to risk of pulmonary hemorrhage...
April 2014: American Journal of Respiratory Cell and Molecular Biology
Reginald Liew
Important advances have been made in the past few years in the fields of clinical cardiac electrophysiology and pacing. Researchers and clinicians have a greater understanding of the pathophysiological mechanisms underlying atrial fibrillation (AF), which has transpired into improved methods of detection, risk stratification, and treatments. The introduction of novel oral anticoagulants has provided clinicians with alternative options in managing patients with AF at moderate to high thromboembolic risk and further data has been emerging on the use of catheter ablation for the treatment of symptomatic AF...
November 2013: Anadolu Kardiyoloji Dergisi: AKD, the Anatolian Journal of Cardiology
Javier Maynar, Fernando Martínez-Sagasti, Manuel Herrera-Gutiérrez, Francisco Martí, Francisco Javier Candel, Javier Belda, Sergio Castaño, José Ángel Sanchez-Izquierdo
BACKGROUND: High levels of endotoxin have been reported as a risk factor for mortality in critical patients. Toraymyxin® is a column designed to remove circulating blood endotoxin by direct hemoperfusion widely used in Japan. OBJECTIVES: To evaluate the effect of direct hemoperfusion with Toraymyxin® (DHP-PMX) as an adjuvant treatment in patients with severe sepsis due to intestinal perforation in terms of hemodynamic function and coagulation abnormalities. METHODS: Prospective cohort study with a historical control group...
June 2013: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Jamil Abuzetun, Tammy Burrns, Luke Hvass, Mohamed El Khashab, Demi McCashland, Hussam Abuissa, Airey Kelly
SESSION TYPE: Arrhythmias PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Atrial fibrillation (AF) is a common arrhythmia, responsible for a 5 fold increase in stroke risk. In the 80-89 year old age group, AF causes 24% of strokes. The use of antithrombotic agents has been proven to decrease these complications. The utilization of these agents in hospitalized patients who develop AF is not well studied.METHODS: We conducted a retrospective chart review of all patients who were admitted to Creighton University Medical Center between December 1, 2010 and January 31, 2011 who had AF diagnosed by telemetry...
October 1, 2012: Chest
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