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Sleep apnea laboral implication

A L Hoefnagel, R Wissler
The vast majority of females affected by hemochromatosis are asymptomatic during childbearing years. We were able to provide effective obstetric anesthesia care to a 35-year-old woman with severe hemochromatosis. She had systolic heart failure with a left ventricular ejection fraction of 15%, severe pulmonary hypertension, mitral insufficiency, a history of ventricular tachycardia, cirrhosis, obstructive sleep apnea, gestational diabetes, and severe scoliosis. A multidisciplinary approach was used to stabilize her heart failure and prepare her for childbirth...
January 2012: International Journal of Obstetric Anesthesia
Leila Kheirandish-Gozal
Sleep-disordered breathing in general and, more particularly, the obstructive sleep apnea syndrome are highly prevalent conditions in children. Although the diagnosis appears relatively straightforward using a sleep study (polysomnography), this labor-intensive and expensive procedure is used in only a minority of cases across the country because of the relative unavailability of pediatric sleep centers. However, the definition of an abnormal sleep study is not a trivial process and requires a methodical delineation of normative data, implication of "abnormal" variables to specific outcomes, and demonstration of cost-effectiveness of such approach...
October 2010: Respiratory Care
C T Bond, R Sprengel, J M Bissonnette, W A Kaufmann, D Pribnow, T Neelands, T Storck, M Baetscher, J Jerecic, J Maylie, H G Knaus, P H Seeburg, J P Adelman
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. The SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of SK3 expression while retaining normal SK3 promoter function. An absence of SK3 did not present overt phenotypic consequences. However, SK3 overexpression induced abnormal respiratory responses to hypoxia and compromised parturition...
September 15, 2000: Science
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