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https://www.readbyqxmd.com/read/29129192/healthcall-delivered-via-smartphone-to-reduce-co-occurring-drug-and-alcohol-use-in-hiv-infected-adults-a-randomized-pilot-trial
#1
Efrat Aharonovich, Malka Stohl, Daniela Cannizzaro, Deborah Hasin
AIMS: Co-occurrence of drug and alcohol use among people living with HIV is linked to poor medication adherence and lack of viral suppression. HealthCall, a technological enhancement of brief Motivational Interviewing (MI), involves brief daily self-monitoring, positive reinforcement, and personalized feedback. This randomized pilot study among people living with HIV investigated the feasibility and efficacy of reducing non-injection drug and alcohol use with MI+HealthCall as adapted for smartphone technology...
December 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29128414/mapping-of-the-prenatal-and-postnatal-methamphetamine-effects-on-d1-like-dopamine-m1-and-m2-muscarinic-receptors-in-rat-central-nervous-system
#2
Vladimir Farar, Paulina Valuskova, Maria Sevcikova, Jaromir Myslivecek, Romana Slamberova
Methamphetamine (MA) is worldwide known drug with high potential for addiction that causes dopamine, noradrenaline and serotonin release. MA is also able to increase acetylcholine levels in adult rodents. The aim of this study was to map changes in D1-like dopamine receptors (DR), M1 and M2 muscarinic receptors (MR), and the total number of MR (M1-M5 MR) in the CNS of rats exposed to MA prenatally and in adulthood. Rat mothers were exposed to MA (5mg/kg s.c.) or saline during the entire gestation period and their male offspring were administered in adulthood with single MA (1mg/kg) or saline injection...
November 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29128305/methamphetamine-induced-impulsivity-during-chronic-methamphetamine-treatment-in-rats-effects-of-the-taar-1-agonist-ro5263397
#3
Zhaoxia Xue, Justin N Siemian, Bernard N Johnson, Yanan Zhang, Jun-Xu Li
Impulsivity is an important personality trait associated with several clinical syndromes including drug abuse. While repeated drug exposure is known to increase certain behavioral responses, such as locomotion, to subsequent drug exposure, few studies have examined whether such sensitization develops for impulsive behavior. In the current study we tested the effects of methamphetamine acutely, during the course of, and upon discontinuation of chronic methamphetamine treatment on impulsive behavior in two models, the 5-choice serial reaction time task (5-CSRTT) and the delay-discounting task which measure impulsive action and impulsive choice, respectively...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29117858/measuring-improvement-in-knowledge-of-drug-policy-reforms-following-a-police-education-program-in-tijuana-mexico
#4
J Arredondo, S A Strathdee, J Cepeda, D Abramovitz, I Artamonova, E Clairgue, E Bustamante, M L Mittal, T Rocha, A Bañuelos, H O Olivarria, M Morales, G Rangel, C Magis, L Beletsky
BACKGROUND: Mexico's 2009 "narcomenudeo reform" decriminalized small amounts of drugs, shifting some drug law enforcement to the states and mandating drug treatment diversion instead of incarceration. Data from Tijuana suggested limited implementation of this harm reduction-oriented policy. We studied whether a police education program (PEP) improved officers' drug and syringe policy knowledge, and aimed to identify participant characteristics associated with improvement of drug policy knowledge...
November 8, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/29114992/working-memory-predicts-methamphetamine-hair-concentration-over-the-course-of-treatment-moderating-effect-of-impulsivity-and-implications-for-dual-systems-model
#5
Adam J Rubenis, Rebecca E Fitzpatrick, Dan I Lubman, Antonio Verdejo-Garcia
High impulsivity and poor executive function are characteristic of methamphetamine use disorder. High arousal in the impulsive system has been proposed to compromise the executive system's regulating ability (i.e. the dual-systems model). While interaction between these variables may partly explain poor treatment outcomes associated with methamphetamine use disorder, previous research has tended to examine each factor separately. We investigated whether high impulsivity (measured with an impulsive choice task) and poor executive function (measured with a working memory task) predict methamphetamine use (determined by hair sample) in the 6 weeks following treatment commencement...
November 8, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29076627/forensic-toxicology-perspectives-of-methadone-associated-deaths-in-tehran-iran-a-seven-year-overview
#6
Maryam Akhgari, Noushin Amini-Shirazi, Fariba Sardari Iravani
Methadone has a long history of pain relief and successful substitute for maintenance treatment in heroin and narcotic addiction. The aim of the study was to assess the trends of methadone-associated deaths in Tehran, Iran, in 2009-2015, from a forensic toxicology point of view. All methadone-associated deaths during this 7-year study period were evaluated according to demographic parameters and forensic toxicology analysis results. Results showed that 1274 cases of methadone-associated deaths were investigated during the study period...
October 27, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29070471/-snitrosylating-protein-disulphide-isomerase-mediates-increased-expression-of-%C3%AE-synuclein-caused-by-methamphetamine-in-mouse-brain
#7
Yue Wang, Wen-Ning Xu, Xiao-Fang Wu, Lin-Nan Zhu, Hong-Hua Qiao, Ling Chen, Chao Liu, Ping-Ming Qiu
OBJECTIVE: To investigate the role of Snitrosylation of protein disulphide isomerasec in methamphetamine (METH)-induced expression of alpha synuclein (αSN) in mouse hippocampus and striatum neurons. METHODS: Forty C57BL/6 mice were randomized equally into saline control group, METH group, L-NNA (a NOS inhibitor) group and L-NNA plus METH group. All the agents were injected intraperitoneally at an interval of 12 h, and a total of 8 injections were administered; in L-NNA plus METH group, METH was injected 30 min after LNNA in each treatment...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29066725/heparan-sulfate-resilience-factor-and-therapeutic-target-for-cocaine-abuse
#8
Jihuan Chen, Tomoya Kawamura, Manveen K Sethi, Joseph Zaia, Vez Repunte-Canonigo, Pietro Paolo Sanna
Substance abuse is a pressing problem with few therapeutic options. The identification of addiction resilience factors is a potential strategy to identify new mechanisms that can be targeted therapeutically. Heparan sulfate (HS) is a linear sulfated polysaccharide that is a component of the cell surface and extracellular matrix. Heparan sulfate modulates the activity and distribution of a set of negatively charged signaling peptides and proteins - known as the HS interactome - by acting as a co-receptor or alternative receptor for growth factors and other signaling peptides and sequestering and localizing them, among other actions...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29065400/dose-dependent-effects-of-binge-like-methamphetamine-dosing-on-dopamine-and-neurotrophin-levels-in-rat-brain
#9
Andreia Moreira da Silva Santos, John P Kelly, Karen M Doyle
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation...
October 24, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29064909/pexacerfont-as-a-crf1-antagonist-for-the-treatment-of-withdrawal-symptoms-in-men-with-heroin-methamphetamine-dependence-a-randomized-double-blind-placebo-controlled-clinical-trial
#10
Mohammad-Javad Morabbi, Emran Razaghi, Ehsan Moazen-Zadeh, Hamideh Safiaghdam, Mohamad R Zarrindast, Nasim Vousoghi, Shahin Akhondzadeh
We assessed the efficacy of pexacerfont, a CRF1 antagonist, for the treatment of withdrawal symptoms. In this randomized, double-blind, placebo-controlled clinical trial, male patients with amphetamine or opioid dependence, on the basis of the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR), in the age range 18-55 years, received either pexacerfont or placebo (300, 200, and 100 mg/day in the first, second, and third week, respectively). No antidepressants, behavioral interventions, or substitution therapy were administered...
October 23, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29055749/effect-of-social-housing-and-oxytocin-on-the-motivation-to-self-administer-methamphetamine-in-female-rats
#11
Christel Westenbroek, Adam N Perry, Lakshmikripa Jagannathan, Jill B Becker
Social housing has been shown to attenuate the motivation for cocaine in female, but not male rats. Here we investigate the potential mechanisms mediating the effect of social housing on the response to methamphetamine (METH). Female rats were individually or socially (pair) housed. The dopamine (DA) response to an acute METH infusion (0.3mg/kg, i.v.) was investigated using in vivo microdialysis in the nucleus accumbens with or without oxytocin (OT; 0.3mg/kg, i.p.) 30min prior to METH. The effects of social housing and OT on self-administered METH (0...
October 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29038721/gender-differences-in-substance-use-patterns-and-disorders-among-an-iranian-patient-sample-receiving-methadone-maintenance-treatment
#12
Amir Ghaderi, Maryam Motmaen, Iraj Abdi, Morad Rasouli-Azad
BACKGROUND: The current prevalence rate of substance abuse and dependence, represents an increasing trend of substance abuse and dependence among women, and the results of epidemiology studies indicate that substance use patterns are different between men and women. This study aimed to determine gender differences in substance use patterns and disorders among the patients undergoing methadone maintenance treatment. METHODS: This cross-sectional study was conducted throughout a specified time bracket ranging from September 2012 through March 2013 in Methadone Maintenance Treatment (MMT) clinics of Mashhad, Iran...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29036309/chiral-analysis-of-methamphetamine-in-oral-fluid-samples-a-method-to-distinguish-licit-from-illicit-drug-use
#13
Damon Borg, Elizabeth Kolb, Cindy Lantigua, Richard Stripp
Methamphetamine (MAMP) is a popular illicit drug abused for its central nervous system stimulating effects. MAMP is also used therapeutically in the treatment of overeating disorders, narcolepsy, attention deficit disorder, in over-the-counter (OTC) products to ease nasal congestion. MAMP exists in two enantiomeric forms, dextrorotary (d-MAMP) or levorotary (l-MAMP). The compounds are similar in chemical structure, simply differing in the orientation of functional groups around the asymmetric carbon. In part because of the availability of l-MAMP in OTC nasal inhalers, forensic guidelines require a sample to contain greater than 20% d-MAMP to consider illicit drug use when interpreting results...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29035917/decreases-in-smoking-during-treatment-for-methamphetamine-use-disorders-preliminary-evidence
#14
Sterling McPherson, Michael Orr, Crystal Lederhos, Michael McDonell, Emily Leickly, Katherine Hirchak, Oladunni A Oluwoye, Sean M Murphy, Matthew Layton, John M Roll
Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Rates of smoking-negative breath samples (carbon monoxide <3 ppm) were compared between the two groups while controlling for baseline carbon monoxide level, marijuana use, MA use, and time...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035155/effects-of-social-and-spatial-contexts-on-young-latinas-methamphetamine-use-initiation
#15
Ann M Cheney, Christine N Newkirk, Vhuhwavho M Nekhavhambe, Matthew Baron Rotondi, Alison Hamilton
In this article, we examine methamphetamine (meth) use initiation as influenced by Latinas' social positions within institutions (e.g., family and economy). We conducted ethnographic fieldwork in five women's residential substance use treatment facilities in Los Angeles County with women who considered meth to be their primary drug of choice. Using an urban ethnographic framing, we demonstrate the effects of low-income young Latinas' spatial- and social-context rendered vulnerability to abuse and neglect, and the resulting emotional distress, on meth use initiation...
October 16, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29030218/acupuncture-suppresses-intravenous-methamphetamine-self-administration-through-gaba-receptor-s-mediation
#16
Yi Jeong Choi, Nam Jun Kim, Rong Jie Zhao, Da Hye Kim, Chae Ha Yang, Hee Young Kim, Young S Gwak, Eun Young Jang, Jae Su Kim, Yun Kyu Lee, Hyun Jong Lee, Sang Nam Lee, Sung Chul Lim, Bong Hyo Lee
OBJECTIVES: Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects of psychostimulant. Based on, the present study investigated if acupuncture could suppress intravenous methamphetamine self-administration behavior. In addition, a possible neuronal mechanism was investigated. MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were trained to intake food pellet...
October 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29024664/the-anterior-insular-cortex%C3%A2-central-amygdala-glutamatergic-pathway-is-critical-to-relapse-after-contingency-management
#17
Marco Venniro, Daniele Caprioli, Michelle Zhang, Leslie R Whitaker, Shiliang Zhang, Brandon L Warren, Carlo Cifani, Nathan J Marchant, Ofer Yizhar, Jennifer M Bossert, Cristiano Chiamulera, Marisela Morales, Yavin Shaham
Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/28993979/methamphetamine-augments-concurrent-astrocyte-mitochondrial-stress-oxidative-burden-and-antioxidant-capacity-tipping-the-balance-in-hiv-associated-neurodegeneration
#18
Kathleen Borgmann, Anuja Ghorpade
Methamphetamine (METH) use, with and without human immunodeficiency virus (HIV)-1 comorbidity, exacerbates neurocognitive decline. Oxidative stress is a probable neurotoxic mechanism during HIV-1 central nervous system infection and METH abuse, as viral proteins, antiretroviral therapy and METH have each been shown to induce mitochondrial dysfunction. However, the mechanisms regulating mitochondrial homeostasis and overall oxidative burden in astrocytes are not well understood in the context of HIV-1 infection and METH abuse...
October 9, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28987070/impulsivity-predicts-poorer-improvement-in-quality-of-life-during-early-treatment-for-people-with-methamphetamine-dependence
#19
Adam J Rubenis, Rebecca E Fitzpatrick, Dan I Lubman, Antonio Verdejo-Garcia
BACKGROUND AND AIMS: Methamphetamine dependence is associated with heightened impulsivity and diminished quality of life, but the link between impulsivity and changes in quality of life during treatment has not been examined. We aimed to investigate how different elements of impulsivity predict change in quality of life in the six weeks after engaging in treatment. DESIGN: Longitudinal, observational cohort study. SETTING: Public and private detoxification and rehabilitation facilities in metropolitan Melbourne, Australia...
October 7, 2017: Addiction
https://www.readbyqxmd.com/read/28970640/a-comparison-of-mazur-s-k-and-area-under-the-curve-for-describing-steep-discounters
#20
Jin H Yoon, Richard De La Garza, Thomas F Newton, Robert Suchting, Matthew T Weaver, Gregory S Brown, Yasmine Omar, Ilana Haliwa
Delay discounting describes how a reward loses value as a function of increasing delay to its receipt and has been reliably associated with a variety of vulnerable populations including those with substance use disorders (SUDs). Two commonly used models to assess delay discounting in the field of SUDs include log k derived from Mazur's hyperbolic equation and area under the curve (AUC). In the current study, we compared log k with AUC on delay discounting data obtained from non-treatment seeking, cocaine- and methamphetamine-dependent volunteers...
September 2017: Psychological Record
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