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https://www.readbyqxmd.com/read/29763685/autophagy-plays-a-pro-survival-role-against-methamphetamine-induced-apoptosis-in-h9c2-cells
#1
Chao Zhao, Yong Mei, Xufeng Chen, Lei Jiang, Yunfei Jiang, Xu Song, Hang Xiao, Jun Wang, Jingsong Zhang
Methamphetamine (METH) is a commonly abused psychostimulant that can induce severe neurotoxicity. Cardiovascular injury caused by METH has recently gained increasing attention; however, the underlying mechanisms remain unclear. As autophagy has been shown to be associated with cell injury, the association between autophagy and METH-mediated cell apoptosis was investigated in the present study. METH treatment significantly increased the expression of two key autophagy proteins, i.e., Beclin-1 and LC3-II, in the cardiomyocyte cell line H9C2...
May 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29756302/velopharyngeal-dysfunction-from-intranasal-substance-abuse-case-series-and-review-of-literature
#2
Peng You, Linda Chow, Anne Dworschak-Stokan, Murad Husein
OBJECTIVE: Intranasal substance abuse with cocaine or opioids can result in complications involving the midline nasal and oral structures. When the defect involves the velopharyngeal musculature, this leads to velopharyngeal dysfunction (VPD). This article aims to illustrate this clinical entity through a series of four patients and a review of the literature. METHODS: A series of four cases of VPD due to intranasal narcotic use and their management are discussed...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29754597/re-wired-treatment-and-peer-support-for-men-who-have-sex-with-men-who-use-methamphetamine
#3
Kent Burgess, Garth Parkhill, Jeremy Wiggins, Simon Ruth, Mark Stoovè
Background This paper examines a methamphetamine treatment and peer support program for gay men and other men who have sex with men (MSM) who use methamphetamine. Australian MSM use illicit drugs including methamphetamine at significantly higher rates than the broader community.1,2 Methamphetamine rates are higher again amongst HIV positive MSM. Methamphetamine in the MSM community is associated with sexual activity and may be associated with psychosocial harms including risk of the transmission of HIV and sexually transmissible infections...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29731519/development-of-intensive-motivational-interviewing-imi-and-modifications-for-treating-women-with-alcohol-use-disorders
#4
Douglas L Polcin, Rachael Korcha, Madhabika Nayak
Women have greater vulnerability to alcohol problems than men. They become intoxicated after drinking half as much as men, develop cirrhosis of the liver more rapidly, and have a greater risk of dying from alcohol-related accidents. Despite more serious consequences related to their drinking, treatment for women with alcohol use disorders has been understudied relative to treatment for men. Intensive motivational interviewing (IMI) is a recent psychotherapeutic intervention for substance abuse problems that draws on the principles of brief motivational interviewing (1-2 session)...
June 2018: Journal of Contemporary Psychotherapy
https://www.readbyqxmd.com/read/29727969/contamination-profiles-mass-loadings-and-sewage-epidemiology-of-neuropsychiatric-and-illicit-drugs-in-wastewater-and-river-waters-from-a-community-in-the-midwestern-united-states
#5
Allie J Skees, Katelyn S Foppe, Bommanna Loganathan, Bikram Subedi
In this study, residues of the neuropsychiatric and illicit drugs including stimulants, opioids, hallucinogens, antischizophrenics, sedatives, and antidepressants were determined in influent and effluent samples from a small wastewater treatment plant, a receiving creek, and river waters in the Four Rivers region of the Midwestern United States. Nineteen neuropsychiatric drugs, eight illicit drugs, and three metabolites of illicit drugs were detected and quantitated in the water samples using HPLC-MS/MS. Residual concentrations of the drugs varied from below the detection limit to sub-μg/L levels...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29718879/methamphetamine-consumption-and-life-threatening-abdominal-complications-a-case-report
#6
Xiaojing Zou, Haiyan Huang, Le Yang, Hong Liu, Yongfeng Li, Qin Xia, Shiying Yuan, Shanglong Yao
RATIONALE: Methamphetamine (METH) abuse is increasing rapidly all over the world and becoming a significant public health concern in China. However, abdominal complications secondary to METH abuse are usually overlooked. We describe an unusual case of gangrenous cholecystitis and small intestinal ischemia due to METH abuse. PATIENT CONCERNS: In this report, a 44-year-old male patient with abdominal pain and hematochezia has a history of crystal meth abuse. DIAGNOSIS: The patient was diagnosed as septic shock, paralytic ileus, gangrenous cholecystitis, and small intestinal ischemia due to METH abuse based on computed tomography (CT) scan, endoscopy examination, laparotomy, and pathology...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715654/relationship-between-the-duration-of-methamphetamine-use-and-psychotic-symptoms-a-two-year-prospective-cohort-study
#7
Jun Ma, Xiao-Dong Li, Tong-Yu Wang, Su-Xia Li, Shi-Qiu Meng, Frederic C Blow, Mark Ilgen, Louisa Degenhardt, Julia Lappin, Ping Wu, Jie Shi, Yan-Ping Bao, Lin Lu
BACKGROUND: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms. METHODS: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale at baseline and four follow-up visits (6, 12, 18 and 24 months after baseline)...
April 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29715538/age-and-sex-dependent-effects-of-methamphetamine-on-cognitive-flexibility-and-5-ht-2c-receptor-localization-in-the-orbitofrontal-cortex-of-sprague-dawley-rats
#8
Emily R Hankosky, Sara R Westbrook, Rachel M Haake, Jari Willing, Lori T Raetzman, Janice M Juraska, Joshua M Gulley
Adolescents and females experience worse outcomes of drug use compared to adults and males. This could result from age- and sex-specific consequences of drug exposure on brain function and cognitive behavior. In the current study, we examined whether a history of intravenous methamphetamine (METH) self-administration impacted cognitive flexibility and 5-HT2C R localization in the orbitofrontal cortex (OFC) in an age- and sex-dependent manner. Strategy shifting was assessed in male and female Sprague-Dawley rats that had self-administered METH (0...
April 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29713787/cognitive-profile-of-ketamine-dependent-patients-compared-with-methamphetamine-dependent-patients-and-healthy-controls
#9
Liang-Jen Wang, Chih-Ken Chen, Shih-Ku Lin, Yi-Chih Chen, Ke Xu, Ming-Chyi Huang
BACKGROUND: Ketamine has emerged as a major substance of abuse worldwide and has been listed with methamphetamine (METH) as two of the most widely available illicit substances in Taiwan. Only a few studies have examined the long-term consequences of chronic and heavy ketamine abuse. We compared the cognitive function of ketamine-dependent patients with that of METH-dependent patients and healthy controls. METHODS: We recruited 165 participants (58 ketamine-dependent and 49 METH-dependent patients who sought treatment and 58 healthy controls) and evaluated them by using a cognitive test battery, the Brief Assessment of Cognition in Schizophrenia, with scores being estimated in reference to normative data in general population...
April 30, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29687308/exposure-to-far-infrared-ray-protects-methamphetamine-induced-behavioral-sensitization-in-glutathione-peroxidase-1-knockout-mice-via-attenuating-mitochondrial-burdens-and-dopamine-d1-receptor-activation
#10
Huynh Nhu Mai, Naveen Sharma, Eun-Joo Shin, Bao Trong Nguyen, Ji Hoon Jeong, Choon-Gon Jang, Eun-Hee Cho, Seung Yeol Nah, Nam Hun Kim, Toshitaka Nabeshima, Hyoung-Chun Kim
Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. We observed that MA treatment significantly increased GPx-1 expression in the striatum of wild-type (WT) mice...
April 23, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29685329/cohort-study-of-hiv-positive-and-negative-methamphetamine-users
#11
Vladimir W Spolsky, Jason Clague, Vivek Shetty
BACKGROUND: The effects of methamphetamine (MA) on caries have been well documented. Little, however, is known about its effects on the periodontium. The authors conducted this study to determine the prevalence and severity of periodontal disease in an urban population of HIV-positive MA users. METHODS: This cross-sectional survey was conducted in one of the most populous urban areas of Los Angeles County, California, beset with high rates of MA use. Participants were recruited by a combination of street outreach methods, referral from drug treatment centers, and word of mouth...
April 20, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29679670/mindfulness-based-relapse-prevention-combined-with-virtual-reality-cue-exposure-for-methamphetamine-addiction-study-protocol-for-a-randomized-controlled-trial
#12
XiJing Chen, Dongmei Wang, Lidan Zhou, Markus Winkler, Paul Pauli, Nan Sui, Yonghui Li
BACKGROUND: Mindfulness-based relapse prevention (MBRP) is a method that combines cognitive behavioral relapse prevention with mindfulness practice. Research shows that MBRP can effectively reduce negative emotions and craving in people with substance use disorders (SUDs). An important part of MBRP is to practice mindfulness meditation to cope with high-risk situations for relapse, such as stimuli and situations associated with drug taking. Virtual reality cue exposure (VRCE) may be a complementary approach to MBRP as it allows for controlled and graded presentations of various high-risk situations with distal and proximal drug cues...
April 18, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29644532/methamphetamine-induces-apoptosis-of-microglia-via-the-intrinsic-mitochondrial-dependent-pathway
#13
Anna V Sharikova, Elizabeth Quaye, Jun Yong Park, Maxwell C Maloney, Habben Desta, Ramkumar Thiyagarajan, Kenneth L Seldeen, Neil U Parikh, Parteet Sandhu, Alexander Khmaladze, Bruce R Troen, Stanley A Schwartz, Supriya D Mahajan
Methamphetamine (METH) is a drug of abuse, the acute and chronic use of which induces neurotoxic responses in the human brain, ultimately leading to neurocognitive disorders. Our goals were to understand the impact of METH on microglial mitochondrial respiration and to determine whether METH induces the activation of the mitochondrial-dependent intrinsic apoptosis pathway in microglia. We assessed the expression of pro- apoptosis genes using qPCR of RNA extracted from a human microglial cell line (HTHU). We examined the apoptosis-inducing effects of METH on microglial cells using digital holographic microscopy (DHM) to quantify real-time apoptotic volume decrease (AVD) in microglia in a noninvasive manner...
April 11, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29626740/the-relationship-between-impulsivity-and-methamphetamine-use-severity-in-a-community-sample
#14
Nathasha R Moallem, Kelly E Courtney, Lara A Ray
BACKGROUND: Abuse of psychostimulants, including methamphetamine (MA), has been linked to heightened impulsivity. While previous research has demonstrated differences in impulsivity between MA users and non-substance users, less is known about variability in impulsivity within MA users and whether the severity of MA use related problems predicts impulsivity within individuals who regularly use MA. This study aims to elucidate the relationship between impulsivity and MA use severity. METHOD: Non-treatment seeking individuals who reported regular MA use (n = 177) completed an impulsivity battery comprising self-report and behavioral measures...
March 27, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29605540/the-management-of-methamphetamine-use-in-sexual-settings-among-men-who-have-sex-with-men-in-malaysia
#15
Sin How Lim, Mohd Akbar, Jeffrey A Wickersham, Adeeba Kamarulzaman, Frederick L Altice
BACKGROUND: The intentional use of illicit drugs for sexual purposes (also known as 'chemsex') is well known within the MSM communities in Malaysia although research in this population is scarce primarily because both drug use and homosexuality are illegal and stigmatised in Malaysia. METHODS: From April to December 2014, interviews were conducted with twenty men (age range 21-43) living in Greater Kuala Lumpur who had sexual intercourse with other men in the past 6 months and who used illicit drugs at least monthly in the past 3 months...
March 28, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29604294/the-effect-of-n-acetylcysteine-or-bupropion-on-methamphetamine-self-administration-and-methamphetamine-triggered-reinstatement-of-female-rats
#16
Sergios Charntikov, Steven T Pittenger, Cindy M Pudiak, Rick A Bevins
N-acetylcysteine and bupropion are two promising candidate medications for treatment of substance use disorder. The effects of N-acetylcysteine or bupropion on methamphetamine self-administration of female rats are not well understood. To fill this gap, this study assessed the effects of N-acetylcysteine (0, 30, 60, or 120 mg/kg) and bupropion (0, 10, 30, and 60 mg/kg) on methamphetamine self-administration of female rats across the natural estrous cycle. Following a completed dose-response curve, responding for methamphetamine self-administration was extinguished and the effects of N-acetylcysteine or bupropion on methamphetamine-triggered reinstatement was evaluated in separate experiments...
March 28, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29602278/dark-classics-in-chemical-neuroscience-methamphetamine
#17
Thomas J Abbruscato, Paul C Trippier
Methamphetamine has the second highest prevalence of drug abuse after cannabis, with estimates of 35 million users worldwide. The (S)-(+)-enantiomer is the illicit drug, active neurostimulant and eutomer, while the (R)-(-)-enantiomer is contained in over the counter decongestants. While designated a schedule II drug in 1970, (S)-(+)-methamphetamine is available by prescription for the treatment of attention-deficit disorder and obesity. The illicit use of (S)-(+)-methamphetamine results in the sudden 'rush' of stimulation to the motivation, movement, pleasure and reward centers in the brain, caused by rapid release of dopamine...
March 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29595368/the-care-of-patients-using-methamphetamine-in-the-emergency-department-perception-of-nurses-residents-and-faculty
#18
John R Richards, J Adam Hawkins, Eric W Acevedo, Erik G Laurin
BACKGROUND: To determine differences in perception between nurses, residents, and faculty regarding characteristics and treatment of patients who use methamphetamine (meth). METHODS: Survey study performed at an urban, university Level I trauma medical center. RESULTS: 80 nurses, 39 residents, and 45 faculty completed the survey. All groups agreed meth was a significant problem nationwide and in our emergency department (ED). Nurses estimated 33% of their patients used meth, which differed from residents (18%) and faculty (15%)...
March 29, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29579065/the-effect-of-estrogenic-compounds-on-psychosis-like-behaviour-in-female-rats
#19
Alyssa Sbisa, Maarten van den Buuse, Andrea Gogos
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however long-term use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alternatives to 17β-estradiol. An isomer of 17β-estradiol, 17α-estradiol, is considered less carcinogenic, and non-feminising in males, however little is known about its potential as a treatment for schizophrenia. Moreover, the mechanism underlying the therapeutic action of estrogens remains unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29576706/rhynchophylline-downregulates-phosphorylated-camp-response-element-binding-protein-nuclear-receptor-related-1-and-brain-derived-neurotrophic-factor-expression-in-the-hippocampus-of-ketamine-induced-conditioned-place-preference-rats
#20
Youli Guo, Chaohua Luo, Genghong Tu, Chan Li, Yi Liu, Wei Liu, Ken Kin Lam Yung, Zhixian Mo
Background: Addiction to ketamine is becoming a serious public health issues, for which there exists no effective treatment. Rhynchophylline (Rhy) is an alkaloid extracted from certain Uncaria species that is well known for both its potent anti-addictive and neuroprotective properties. Increasing evidence supports the contributions of cAMP response element binding protein (CREB), nuclear receptor-related-1 (Nurr1), and brain-derived neurotrophic factor (BDNF) in modulating neural and behavioral plasticity which was induced by addictive drugs...
January 2018: Pharmacognosy Magazine
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