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https://www.readbyqxmd.com/read/28531769/increases-in-prescription-opioid-injection-abuse-among-treatment-admissions-in-the-united-states-2004-2013
#1
Christopher M Jones, Aleta Christensen, R Matthew Gladden
BACKGROUND: The 2015 HIV outbreak in Indiana associated with prescription opioid injection coupled with rising rates of hepatitis C, especially in areas with long-standing opioid abuse, have raised concerns about prescription opioid injection. However, research on this topic is limited. We assessed trends in treatment admissions reporting injection, smoking, and inhalation abuse of prescription opioids and examined characteristics associated with non-oral routes of prescription opioid abuse in the U...
May 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28527425/effects-of-the-summer-holiday-season-on-uv-filter-and-illicit-drug-concentrations-in-the-korean-wastewater-system-and-aquatic-environment
#2
Ki Yong Kim, Kalu Ibe Ekpeghere, Hee-Jin Jeong, Jeong-Eun Oh
Seasonal variations in the concentrations of eight ultraviolet (UV) filters and 22 illicit drugs including their metabolites in the Korean aquatic environment were investigated. Seawater samples from three beaches, water samples from two rivers, and influents and effluents from three wastewater treatment plants were analyzed. The UV filter concentrations in the seawater, river water, and effluent samples were 39.4-296, 35.4-117, and 6.84-51.1 ng L(-1), respectively. The total UV filter concentrations in the seawater samples were 1...
May 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28511099/the-social-exigencies-of-the-gateway-progression-to-the-use-of-illicit-drugs-from-adolescence-into-adulthood
#3
Roy Otten, Chung Jung Mun, Thomas J Dishion
BACKGROUND: There is limited empirical integration between peer clustering theory and the Gateway framework. The goal of the present study was to test the hypothesis that friendship associations partly predict gateway escalations in the use of drugs from adolescence to adulthood. METHOD: This longitudinal study analyzed 3 waves of data from a community sample of 711 male and female participants without a history of illicit drug use reporting drug use at age 17, 22, and 27...
May 11, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28501070/use-of-evidence-based-decision-making-in-comprehensive-dental-treatment-of-a-patient-with-meth-mouth-a-case-report
#4
Saad A Al Hazzani
OBJECTIVE: This case report illustrates the use of evidence-based practice in formulating a comprehensive dental treatment plan for a patient who presented himself with signs of oral health debilitation accompanying methamphetamine (MA) abuse called "meth mouth" with the goal of providing dental care practitioners in Saudi Arabia with an insight into the global problem of MA abuse and its impact on oral health. BACKGROUND: This report documents the case of a 22-year-old male patient who reported to the clinic with rampant caries caused due to MA abuse exacerbated by poor oral hygiene and smoking habit...
June 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28499448/comparison-of-demographic-characteristics-and-psychiatric-comorbidity-among-methamphetamine-heroin-and-methamphetamine-heroin-co-dependent-males-in-hunan-china
#5
Huixi Dong, Mei Yang, Liang Liu, Chenxi Zhang, Mengqi Liu, Yidong Shen, Huanzhong Liu, Wei Hao
BACKGROUND: There is little research of psychiatric comorbidity differences among people with different types of drug dependence in Chinese population. We explored demographic and comorbid psychiatric differences among methamphetamine- dependent males (MDs), heroin-dependent males (HDs) and methamphetamine and heroin co-dependent males (M/HDs) in Hunan province, China. METHODS: A cross-sectional, structured and clinical interview method was used to examine differences in DSM-IV-TR Axis I Disorders among 346 MDs, 698 HDs and 247 M/HDs from three compulsory rehabilitation centers and two voluntary rehabilitation centers in Hunan...
May 12, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28496953/estrogen-and-progesterone-replacement-therapy-prevent-methamphetamine-induced-synaptic-plasticity-impairment-in-ovariectomized-rats
#6
Hamed Ghazvini, Mohammad Shabani, Majid Asadi-Shekaari, Solmaz Khalifeh, Khadijeh Esmaeilpour, Mehdi Khodamoradi, Vahid Sheibani
BACKGROUND: Methamphetamine (METH) is one of the most popular psychostimulants which produce long lasting learning and memory impairment. Previous studies have indicated that estrogen and progesterone replacement therapy attenuate cognitive impairment against a wide array of neurodegenerative diseases. Present study was designed to figure out the effects of estrogen, progesterone alone or in combination, on early long-term potentiation (E-LTP) at the cornu ammonis (CA1) area of the hippocampus in METH-exposed ovariectomized (OVX) rat...
July 2016: Addiction & Health
https://www.readbyqxmd.com/read/28495611/hiv-1-tat-protein-enhances-sensitization-to-methamphetamine-by-affecting-dopaminergic-function
#7
James P Kesby, Julia A Najera, Benedetto Romoli, Yiding Fang, Liana Basova, Amanda Birmingham, Maria Cecilia G Marcondes, Davide Dulcis, Svetlana Semenova
Methamphetamine abuse is common among humans with immunodeficiency virus (HIV). The HIV-1 regulatory protein TAT induces dysfunction of mesolimbic dopaminergic systems which may result in impaired reward processes and contribute to methamphetamine abuse. These studies investigated the impact of TAT expression on methamphetamine-induced locomotor sensitization, underlying changes in dopamine function and adenosine receptors in mesolimbic brain areas and neuroinflammation (microgliosis). Transgenic mice with doxycycline-induced TAT protein expression in the brain were tested for locomotor activity in response to repeated methamphetamine injections and methamphetamine challenge after a 7-day abstinence period...
May 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28495376/gabaa-receptor-positive-allosteric-modulators-modify-the-abuse-related-behavioral-and-neurochemical-effects-of-methamphetamine-in-rhesus-monkeys
#8
Laís F Berro, Monica L Andersen, Sergio Tufik, Leonard L Howell
GABAA receptor positive allosteric modulators (GABAA receptor modulators) are commonly used for the treatment of insomnia. Nevertheless, the effects of these compounds on psychostimulant-induced sleep impairment are poorly understood. Because GABAA receptor modulators have been shown to decrease the abuse-related effects of psychostimulants, the aim of the present study was to evaluate the effects of temazepam (0.3, 1.0 or 3.0 mg/kg) and eszopiclone (0.3, 1.0 or 3.0 mg/kg), two GABAA receptor modulators, on the behavioral neuropharmacology of methamphetamine in adult rhesus macaques (n = 5)...
May 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28493273/use-of-amphetamine-type-stimulants-in-the-islamic-republic-of-iran-2004-2015-a-review
#9
REVIEW
Behrang Shadloo, Masoumeh Amin-Esmaeili, Minoo Haft-Baradaran, Alireza Noroozi, Reza Ghorban-Jahromi, Afarin Rahimi-Movaghar
Amphetamine-type stimulants (ATS) are the second most commonly used illicit drugs in the world, after cannabis. The production of ATS has increased worldwide, including in the Middle East. This review aims to assess ATS use in the Islamic Republic of Iran. PubMed, Scientific Information Database (a national database) and Iranian Center for Addiction Studies were searched. The review included studies on the general population, university and high school students, other specific populations, and drug users. The result show that self-reported methamphetamine and ecstasy use in 2016 was < 1% in the general population and university and high-school students, but the prevalence was higher in certain groups...
May 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28476274/correlates-of-three-year-outpatient-medical-care-use-among-rural-stimulant-users
#10
Michael A Cucciare, Xiaotong Han, Christine Timko, Nickolas Zaller, Kristina M Kennedy, Brenda M Booth
Outpatient medical care (OMC) settings are a care context in which effective management of unhealthy substance use can occur. However, no studies have documented rates of OMC use and characteristics of OMC use among rural substance users. This study sought to examine the rates and frequency of OMC use in a sample of rural drug users over a three-year period. We also explored characteristics of participants associated with use of OMCs over time. Data were collected from June 2005 to September 2007 from a natural history study of 710 stimulant users living in rural communities...
June 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28473777/investigating-the-role-of-serotonin-in-methamphetamine-psychosis-unaltered-behavioral-effects-of-chronic-methamphetamine-in-5-ht1a-knockout-mice
#11
Emily J Jaehne, Dzeneta Ameti, Tehani Paiva, Maarten van den Buuse
Methamphetamine (Meth) is a widely abused stimulant drug, but this abuse is associated with an increased risk of developing psychosis. In addition to its well-known action on brain dopamine, Meth also affects serotonergic (5-HT) neurons. The aim of this study was to investigate this role in mice, which lack one of the main serotonin receptors, the 5-HT1A receptor, which has been implicated in both schizophrenia and Meth-induced psychosis. Male and female wild-type or 5-HT1A knockout (KO) mice received daily treatment with increasing doses of methamphetamine from 6 to 9 weeks of age (1-4 mg/kg/day twice a day)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28457879/the-role-of-system-xc-in-methamphetamine-induced-dopaminergic-neurotoxicity-in-mice
#12
Duy-Khanh Dang, Eun-Joo Shin, Hai-Quyen Tran, Dae-Joong Kim, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Hideyo Sato, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim
The cystine/glutamate antiporter (system Xc(-), Sxc) transports cystine into cell in exchange for glutamate. Since xCT is a specific subunit of Sxc, we employed xCT knockout mice and investigated whether this antiporter affected methamphetamine (MA)-induced dopaminergic neurotoxicity. MA treatment significantly increased striatal oxidative burdens in wild type mice. xCT inhibitor [i.e., S-4-carboxy-phenylglycine (CPG), sulfasalazine] or an xCT knockout significantly protected against these oxidative burdens...
April 27, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28450692/the-ethyl-acetate-fraction-of-a-methanolic-extract-of-unripe-noni-morinda-citrifolia-linn-fruit-exhibits-a-biphasic-effect-on-the-dopaminergic-system-in-mice
#13
Vijayapandi Pandy, Megala Narasingam, Kamini Vijeepallam, Syam Mohan, Vasudevan Mani, Zahurin Mohamed
In earlier ex vivo studies, we reported the biphasic effect of a methanolic extract of unripe Morinda citrifolia fruit (MMC) on dopamine-induced contractility in isolated rat vas deferens preparations. The present in vivo study was designed and undertaken to further explore our earlier ex vivo findings. This study examined the effect of the ethyl acetate fraction of a methanolic extract of unripe Morinda citrifolia Linn. fruit (EA-MMC; 5-100 mg/kg, p.o.) on the dopaminergic system using mouse models of apomorphine-induced climbing time and climbing behavior, methamphetamine-induced stereotypy (sniffing, biting, gnawing, and licking) and haloperidol-induced catalepsy using the bar test...
April 26, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#14
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28445899/evidence-based-guidelines-for-the-pharmacologic-management-of-methamphetamine-dependence-relapse-prevention-chronic-methamphetamine-related-and-comorbid-psychiatric-disorders-in-post-acute-settings
#15
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf-Dietrich Braunwarth, Ursula Havemann-Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf
The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 publications included...
May 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28444326/preclinical-evidence-that-5-ht1b-receptor-agonists-show-promise-as-medications-for-psychostimulant-use-disorders
#16
Raul Garcia, Austin R Cotter, Kenneth Leslie, M Foster Olive, Janet L Neisewander
Background: 5-HT1B receptor (5-HT1BR) agonists enhance cocaine intake during daily self-administration sessions, but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1BR agonists produce similar abstinence-dependent effects on methamphetamine intake. Methods: Male rats were trained to self-administer methamphetamine (0.1 mg/kg, IV) on low (FR5 and VR5) and high (progressive ratio; PR) effort schedules of reinforcement until intake was stable...
April 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28441274/-meth-mouth-an-interdisciplinary-review-of-a-dental-and-psychiatric-condition
#17
Cornel N Stanciu, Magdalena Glass, Brian C Muzyka, Oliver M Glass
OBJECTIVE: Chronic methamphetamine (MA) users experience many dental problems, a condition characterized as "meth mouth." These devastating effects on dentition is the main reason why many seek professional help. Here, we discuss the effects of MA on oral health and advocate for improved collaboration between dentists and mental health providers. We also introduce a dental evaluation tool with the goal of improving the quality of care for this often-marginalized patient population. METHODS: A Medline literature search (1985-2016) was conducted with keywords "meth mouth," "methamphetamine AND oral health"; "methamphetamine AND dental"; "methamphetamine AND dentist...
April 24, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28421682/predicting-abstinence-from-methamphetamine-use-after-residential-rehabilitation-findings-from-the-methamphetamine-treatment-evaluation-study
#18
Rebecca McKetin, Astrid Kothe, Amanda L Baker, Nicole K Lee, Joanne Ross, Dan I Lubman
INTRODUCTION AND AIMS: We previously found that residential rehabilitation increased continuous abstinence from methamphetamine use 1 year after treatment. We examine what client and treatment characteristics predict this outcome. DESIGN AND METHODS: Participants (n = 176) were dependent on methamphetamine and entering residential rehabilitation for methamphetamine use. Simultaneous logistic regression was used to identify independent predictors of continuous abstinence from methamphetamine use at 1 year follow-up...
April 18, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28421529/suppression-of-methamphetamine-self-administration-by-ketamine-pre-treatment-is-absent-in-the-methylazoxymethanol-mam-rat-model-of-schizophrenia
#19
Jana Ruda-Kucerova, Zuzana Babinska, Tibor Stark, Vincenzo Micale
Ketamine may prove to be a potential candidate in treating the widespread drug addiction/substance abuse epidemic among patients with schizophrenia. Clinical studies have shown ketamine to reduce cocaine and heroin cravings. However, the use of ketamine remains controversial as it may exacerbate the symptoms of schizophrenia. Therefore, the aim of this study is to characterize the effects of ketamine on drug addiction in schizophrenia using the methylazoxymethanol (MAM) acetate rat model on operant IV methamphetamine (METH) self-administration...
April 18, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28408317/involvement-of-puma-in-pericyte-migration-induced-by-methamphetamine
#20
Yanhong Zhang, Yuan Zhang, Ying Bai, Jie Chao, Gang Hu, Xufeng Chen, Honghong Yao
Mounting evidence indicates that methamphetamine causes blood-brain barrier damage, with emphasis on endothelial cells. The role of pericytes in methamphetamine-induced BBB damage remains unknown. Our study demonstrated that methamphetamine increased the migration of pericytes from the endothelial basement membrane. However, the detailed mechanisms underlying this process remain poorly understood. Thus, we examined the molecular mechanisms involved in methamphetamine-induced pericyte migration. The results showed that exposure of C3H/10T1/2 cells and HBVPs to methamphetamine increased PUMA expression via activation of the sigma-1 receptor, MAPK and Akt/PI3K pathways...
April 10, 2017: Experimental Cell Research
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