Hanli Xu, Yulin Kang, Tingming Liang, Sifen Lu, Xiaolin Xia, Zuhong Lu, Lingming Hu, Li Guo, Lishu Zhang, Jiaqiang Huang, Lin Ye, Peiye Jiang, Yi Liu, Li Xinyi, Jin Zhai, Zi Wang, Yangyang Liu
BACKGROUND: Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese. METHODS: A total of 1000 Chinese users of illicit drugs and 9693 healthy controls were enrolled and underwent single nucleotide polymorphism (SNP)-based and haplotype-based association analyses via whole-genome genotyping. RESULTS: Both single-SNP and haplotype tests revealed associations between illicit drug use and several immune-related genes in the major histocompatibility complex (MHC) region (SNP association: log10 BF = 15...
March 6, 2024: BMC Genomics