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Methamphetamine addiction

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https://www.readbyqxmd.com/read/29147885/proceedings-of-the-2017-isev-symposium-on-hiv-neurohiv-drug-abuse-evs
#1
Guoku Hu, Sowmya Yelamanchili, Fatah Kashanchi, Norman Haughey, Vincent C Bond, Kenneth W Witwer, Lynn Pulliam, Shilpa Buch
Despite the success of combination antiretroviral therapy (cART), there is increased prevalence of HIV-associated neurocognitive disorders (HAND) in HIV-1-infected individuals on cART, which poses a major health care challenge. Adding further complexity to this long-term antiretroviral use is the comorbidity with drugs of abuse such as morphine, cocaine, and methamphetamine, which can in turn, exacerbate neurologic and cognitive deficits associated with HAND. Furthermore, HIV proteins, such as the transactivator of transcription (Tat) and the envelope protein (gp120), as well as antiretrovirals themselves can also contribute to the progression of neurodegeneration underlying HAND...
November 16, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29134789/either-at-left-or-right-both-high-and-low-frequency-rtms-of-dorsolateral-prefrontal-cortex-decreases-cue-induced-craving-for-methamphetamine
#2
Qingming Liu, Ying Shen, Xinyu Cao, Yongqiang Li, Yijiang Chen, Wei Yang, Ti-Fei Yuan
BACKGROUND AND OBJECTIVES: The study is to investigate if left or right dorsolateral prefrontal cortex is important in modulating the craving to drug related cues. METHODS: The present investigation examined different combinations between left/right and high/low frequency rTMS on cue induced craving to methamphetamine, with active sham rTMS on P3 region on a total of 50 subjects. RESULTS: The results showed that either at left or right side, both high and low frequency rTMS are effective in decreasing the cue induced craving to methamphetamine...
November 14, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29128447/developmental-perspectives-on-methamphetamine-abuse-exploring-adolescent-vulnerabilities-on-brain-and-behavior
#3
REVIEW
Sophia J Luikinga, Jee Hyun Kim, Christina J Perry
Most people that experience illicit drugs do so for the first time during adolescence, and methamphetamine (meth) is no exception. Therefore, research into the effects of meth should highlight the adolescent period. Despite this, the vast majority of current literature has mainly focused on meth exposure during adulthood. In this review, we first describe existing literature that compares the behavioral effects of meth where exposure occurs in adolescence compared to adulthood. Given that there are actually very few such studies, we also look at what is known about neural effects of meth in the adult brain, and relate these to normal neural development occurring during the adolescent period to establish how meth may target maturing regions and related neurochemistry...
November 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29128414/mapping-of-the-prenatal-and-postnatal-methamphetamine-effects-on-d1-like-dopamine-m1-and-m2-muscarinic-receptors-in-rat-central-nervous-system
#4
Vladimir Farar, Paulina Valuskova, Maria Sevcikova, Jaromir Myslivecek, Romana Slamberova
Methamphetamine (MA) is worldwide known drug with high potential for addiction that causes dopamine, noradrenaline and serotonin release. MA is also able to increase acetylcholine levels in adult rodents. The aim of this study was to map changes in D1-like dopamine receptors (DR), M1 and M2 muscarinic receptors (MR), and the total number of MR (M1-M5 MR) in the CNS of rats exposed to MA prenatally and in adulthood. Rat mothers were exposed to MA (5mg/kg s.c.) or saline during the entire gestation period and their male offspring were administered in adulthood with single MA (1mg/kg) or saline injection...
November 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29105663/exacerbated-craving-in-the-presence-of-stress-and-drug-cues-in-drug-dependent-patients
#5
Kenzie L Preston, William J Kowalczyk, Karran A Phillips, Michelle L Jobes, Massoud Vahabzadeh, Jia-Ling Lin, Mustapha Mezghanni, David H Epstein
In addiction, risk factors for craving and use include stress and drug-related cues. Stress and cues have additive or more-than-additive effects on drug seeking in laboratory animals, but, surprisingly, seem to compete with one another (ie, exert less-than-additive effects) in human laboratory studies of craving. We sought heretofore elusive evidence that human drug users could show additive (or more-than-additive) effects of stress and cues on craving, using ecological momentary assessment (EMA). Outpatients (N=182) maintained on daily buprenorphine or methadone provided self-reports of stress, craving, mood, and behavior on electronic diaries for up to 16 weeks...
November 6, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29076627/forensic-toxicology-perspectives-of-methadone-associated-deaths-in-tehran-iran-a-seven-year-overview
#6
Maryam Akhgari, Noushin Amini-Shirazi, Fariba Sardari Iravani
Methadone has a long history of pain relief and successful substitute for maintenance treatment in heroin and narcotic addiction. The aim of the study was to assess the trends of methadone-associated deaths in Tehran, Iran, in 2009-2015, from a forensic toxicology point of view. All methadone-associated deaths during this 7-year study period were evaluated according to demographic parameters and forensic toxicology analysis results. Results showed that 1274 cases of methadone-associated deaths were investigated during the study period...
October 27, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29066725/heparan-sulfate-resilience-factor-and-therapeutic-target-for-cocaine-abuse
#7
Jihuan Chen, Tomoya Kawamura, Manveen K Sethi, Joseph Zaia, Vez Repunte-Canonigo, Pietro Paolo Sanna
Substance abuse is a pressing problem with few therapeutic options. The identification of addiction resilience factors is a potential strategy to identify new mechanisms that can be targeted therapeutically. Heparan sulfate (HS) is a linear sulfated polysaccharide that is a component of the cell surface and extracellular matrix. Heparan sulfate modulates the activity and distribution of a set of negatively charged signaling peptides and proteins - known as the HS interactome - by acting as a co-receptor or alternative receptor for growth factors and other signaling peptides and sequestering and localizing them, among other actions...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29063448/prenatal-methamphetamine-exposure-is-associated-with-corticostriatal-white-matter-changes-in-neonates
#8
Fleur L Warton, Paul A Taylor, Christopher M R Warton, Christopher D Molteno, Pia Wintermark, Nadine M Lindinger, Lilla Zöllei, Andre van der Kouwe, Joseph L Jacobson, Sandra W Jacobson, Ernesta M Meintjes
Diffusion tensor imaging (DTI) studies have shown that prenatal exposure to methamphetamine is associated with alterations in white matter microstructure, but to date no tractography studies have been performed in neonates. The striato-thalamo-orbitofrontal circuit and its associated limbic-striatal areas, the primary circuit responsible for reinforcement, has been postulated to be dysfunctional in drug addiction. This study investigated potential white matter changes in the striatal-orbitofrontal circuit in neonates with prenatal methamphetamine exposure...
October 23, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29051727/syvn1-an-erad-e3-ubiquitin-ligase-is-involved-in-gabaa%C3%AE-1-degradation-associated-with-methamphetamine-induced-conditioned-place-preference
#9
Dong-Liang Jiao, Yan Chen, Yao Liu, Yun-Yue Ju, Jian-Dong Long, Jiang Du, Chang-Xi Yu, Yu-Jun Wang, Min Zhao, Jing-Gen Liu
Abuse of methamphetamine (METH), a powerful addictive amphetamine-type stimulants (ATS), is becoming a global public health problem. The gamma-aminobutyric acid (GABA)ergic system plays a critical role in METH use disorders. By using rat METH conditioned place preference (CPP) model, we previously demonstrated that METH-associated rewarding memory formation was associated with the reduction of GABAAα1 expression in the dorsal straitum (Dstr), however, the underlying mechanism was unclear. In the present study, we found that METH-induced CPP formation was accompanied by a significant increase in the expression of Synovial apoptosis inhibitor 1 (SYVN1), an endoplasmic reticulum (ER)-associated degradation (ERAD) E3 ubiquitin ligase, in the Dstr...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29024664/the-anterior-insular-cortex%C3%A2-central-amygdala-glutamatergic-pathway-is-critical-to-relapse-after-contingency-management
#10
Marco Venniro, Daniele Caprioli, Michelle Zhang, Leslie R Whitaker, Shiliang Zhang, Brandon L Warren, Carlo Cifani, Nathan J Marchant, Ofer Yizhar, Jennifer M Bossert, Cristiano Chiamulera, Marisela Morales, Yavin Shaham
Despite decades of research on neurobiological mechanisms of psychostimulant addiction, the only effective treatment for many addicts is contingency management, a behavioral treatment that uses alternative non-drug reward to maintain abstinence. However, when contingency management is discontinued, most addicts relapse to drug use. The brain mechanisms underlying relapse after cessation of contingency management are largely unknown, and, until recently, an animal model of this human condition did not exist...
October 11, 2017: Neuron
https://www.readbyqxmd.com/read/28960736/safety-risk-and-aggression-health-professionals-experiences-of-caring-for-people-affected-by-methamphetamine-when-presenting-for-emergency-care
#11
Kim Usher, Debra Jackson, Cindy Woods, Jan Sayers, Rachel Kornhaber, Michelle Cleary
The crystalline form of methamphetamine, commonly known as crystal meth (crystal methamphetamine) or ICE, is a highly-addictive and powerful stimulant. Users of crystal meth often require emergency care, and are associated with a substantial burden of care by emergency care providers. The aim of the present qualitative study was to explore health professionals' experiences of providing care for patients affected by ICE who presented to the emergency department (ED). Nine semistructured interviews were conducted...
October 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28960173/family-behavior-therapy-for-alcohol-and-drug-problems-in-later-life
#12
Christopher P Plant, Jason M Holland
Alcohol and drug use problems among older individuals are a growing public health concern. However, few treatments have been developed for this population, despite an emerging body of literature suggesting that older substance users are more likely to benefit from interventions tailored to meet their specific needs. In particular, older adults with a history of substance abuse have expressed a preference for treatments that focus on financial problems, physical health, and mobility issues, and make attempts to prescriptively involve supportive others in treatment...
June 30, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28956316/anesthetic-implications-of-recreational-drug-use
#13
Pierre Beaulieu
PURPOSE: As the use of recreational drugs increases, the likelihood of an anesthesiologist perioperatively encountering patients using or addicted to these drugs will also increase. PRINCIPAL FINDINGS: Addicted patients may present for anesthetic care in a variety of circumstances in everyday elective surgeries or in acute or life-saving situations, such as emergency Cesarean delivery or trauma surgery. Therefore, it is important for anesthesiologists to know about the most common illicit drugs being used, their clinical presentation and side effects, and the anesthetic options that are beneficial or detrimental to these patients...
September 27, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28942287/the-costs-of-crime-associated-with-stimulant-use-in-a-canadian-setting
#14
Benjamin Enns, Emanuel Krebs, Kora DeBeck, Kanna Hayashi, M-J Milloy, Lindsey Richardson, Evan Wood, Bohdan Nosyk
BACKGROUND: Costs attributable to criminal activity are a major component of the economic burden of substance use disorders, yet there is a paucity of empirical evidence on this topic. Our aim was to estimate the costs of crime associated with different forms and intensities of stimulant use. METHODS: Retrospective cohort study, including individuals from three prospective cohorts in Vancouver, Canada, measured biannually (2011-2015), reporting stimulant use at baseline assessment...
September 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28941573/hypothalamic-pituitary-adrenal-axis-responsiveness-to-methamphetamine-is-modulated-by-gonadectomy-in-males
#15
Jason S Jacobskind, Zachary J Rosinger, Damian G Zuloaga
Sex differences in patterns of methamphetamine (MA) abuse have been reported with females (humans and rodents) showing an elevated addiction phenotype. Previous findings indicate MA-induced hypothalamic-pituitary-adrenal (HPA) axis activation is also sexually dimorphic with females exhibiting an elevated glucocorticoid release and differential neural activation patterns within HPA axis-associated brain regions. These effects may contribute to sex differences in abuse. To determine the role of gonadal hormones in mediating sex differences in MA-induced glucocorticoids, male and female C57BL/6J mice were gonadectomized or sham-operated, and following recovery, injected with MA (5mg/kg) and sacrificed 60min or 120min later...
December 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28939767/dopamine-transporter-phosphorylation-site-threonine-53-is-stimulated-by-amphetamines-and-regulates-dopamine-transport-efflux-and-cocaine-analog-binding
#16
Sathya Challasivakanaka, Juan Zhen, Margaret E Smith, Maarten E A Reith, James D Foster, Roxanne A Vaughan
The dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine neurotransmission through reuptake of extracellular transmitter and is a target for addictive compounds such as cocaine, amphetamine (AMPH), and methamphetamine (METH). Reuptake is regulated by kinase pathways and drug exposure, allowing for fine-tuning of clearance in response to specific conditions, and here we examine the impact of transporter ligands on DAT residue Thr53, a proline-directed phosphorylation site previously implicated in AMPH-stimulated efflux mechanisms...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28939573/does-psychedelic-drug-use-reduce-risk-of-suicidality-evidence-from-a-longitudinal-community-based-cohort-of-marginalised-women-in-a-canadian-setting
#17
Elena Argento, Steffanie A Strathdee, Kenneth Tupper, Melissa Braschel, Evan Wood, Kate Shannon
OBJECTIVE: This study aimed to longitudinally investigate whether ever having used a psychedelic drug can have a protective effect on incidence of suicidality among marginalised women. DESIGN: Longitudinal community-based cohort study. SETTING: Data were drawn from a prospective, community-based cohort of marginalised women in Metro Vancouver, Canada. PARTICIPANTS: 766 women completed the baseline questionnaire between January 2010 and August 2014...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28895615/-methamphetamine-use-in-central-germany-a-qualitative-study-on-consumer-groups-and-motives-from-the-experts-perspective
#18
Laura Hoffmann, Nadine Schumann, Matthias Richter
Background Methamphetamine is one of the most consumed illegal drugs worldwide. In Germany, Methamphetamine shows the highest rates of growth in comparison to other illegal substances in recent years. Particularly Central Germany has been struck by a high rise in consumption. International studies indicate that there is no specific group of people that can be identified as Methamphetamine users. Different consumption patterns in terms of Methamphetamine use can be identified within various social groups. This qualitative study will explore different consumer groups among methamphetamine users, their motives, and how they differ by drug addiction type...
September 11, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28890714/gut-microbiota-analysis-in-rats-with-methamphetamine-induced-conditioned-place-preference
#19
Tingting Ning, Xiaokang Gong, Lingling Xie, Baomiao Ma
Methamphetamine abuse is a major public health crisis. Because accumulating evidence supports the hypothesis that the gut microbiota plays an important role in central nervous system (CNS) function, and research on the roles of the microbiome in CNS disorders holds conceivable promise for developing novel therapeutic avenues for treating CNS disorders, we sought to determine whether administration of methamphetamine leads to alterations in the intestinal microbiota. In this study, the gut microbiota profiles of rats with methamphetamine-induced conditioned place preference (CPP) were analyzed through 16S rRNA gene sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28889212/cocaine-like-discriminative-stimulus-effects-of-norepinephrine-preferring-monoamine-releasers-time-course-and-interaction-studies-in-rhesus-monkeys
#20
Stephen J Kohut, David S Jacobs, Richard B Rothman, John S Partilla, Jack Bergman, Bruce E Blough
RATIONALE: The therapeutic potential of monoamine releasers with prominent dopaminergic effects is hindered by their high abuse liability. OBJECTIVES: The present study examined the effects of several novel "norepinephrine (NE)-preferring" monoamine releasers relative to non-selective monoamine releasers, d-amphetamine and d-methamphetamine, in rhesus monkeys trained to discriminate cocaine. NE-preferring releasers were approximately 13-fold more potent for NE compared to dopamine release and ranged in potency for serotonin release (PAL-329 < l-methamphetamine < PAL-169)...
September 9, 2017: Psychopharmacology
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