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Methamphetamine addiction

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https://www.readbyqxmd.com/read/28323108/chronic-methamphetamine-exposure-significantly-decreases-microglia-activation-in-the-arcuate-nucleus
#1
Steven A Lloyd, Beau Corkill, Matthew C Bruster, Rick L Roberts, Ryan A Shanks
Methamphetamine is a powerful psychostimulant drug and its use and abuse necessitates a better understanding of its neurobiobehavioral effects. The acute effects of binge dosing of methamphetamine on the neurons in the CNS are well studied. However, the long-term effects of chronic, low-dose methamphetamine are less well characterized, especially in other cell types and areas outside of the major dopamine pathways. Mice were administered 5mg/kg/day methamphetamine for ten days and brain tissue was analyzed using histochemistry and image analysis...
March 16, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28319198/methamphetamine-induces-shati-nat8l-expression-in-the-mouse-nucleus-accumbens-via-creb-and-dopamine-d1-receptor-dependent-mechanism
#2
Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta
Shati/Nat8L significantly increased in the nucleus accumbens (NAc) of mice after repeated methamphetamine (METH) treatment. We reported that Shati/Nat8L overexpression in mouse NAc attenuated METH-induced hyperlocomotion, locomotor sensitization, and conditioned place preference. We recently found that Shati/Nat8L overexpression in NAc regulates the dopaminergic neuronal system via the activation of group II mGluRs by elevated N-acetylaspartylglutamate following N-acetylaspartate increase due to the overexpression...
2017: PloS One
https://www.readbyqxmd.com/read/28315272/sigma-receptors-and-substance-use-disorders
#3
Valentina Sabino, Callum Hicks, Pietro Cottone
Thanks to advances in neuroscience, addiction is now recognized as a chronic brain disease with genetic, developmental, and cultural components. Drugs of abuse, including alcohol, are able to produce significant neuroplastic changes responsible for the profound disturbances shown by drug addicted individuals. The current lack of efficacious pharmacological treatments for substance use disorders has encouraged the search for novel and more effective pharmacotherapies. Growing evidence strongly suggests that Sigma Receptors are involved in the addictive and neurotoxic properties of abused drugs, including cocaine , methamphetamine , and alcohol...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28302577/methamphetamine-effects-on-the-brain-gut-and-immune-system
#4
REVIEW
Monica D Prakash, Kathy Tangalakis, Juliana Antonipillai, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentration in the short-term. However, chronic use and/or at higher doses METH use often results in psychosis, depression, delusions and violent behavior. METH was formerly used to treat conditions such as obesity and attention deficit hyperactivity disorder, but now is primarily used recreationally. Its addictive nature has led to METH abuse becoming a global problem. At a cellular level, METH exerts a myriad of effects on the central and peripheral nervous systems, immune system and the gastrointestinal system...
March 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28297025/association-of-stimulant-use-with-dopaminergic-alterations-in-users-of-cocaine-amphetamine-or-methamphetamine-a-systematic-review-and-meta-analysis
#5
Abhishekh H Ashok, Yuya Mizuno, Nora D Volkow, Oliver D Howes
Importance: Stimulant use disorder is common, affecting between 0.3% and 1.1% of the population, and costs more than $85 billion per year globally. There are no licensed treatments to date. Several lines of evidence implicate the dopamine system in the pathogenesis of substance use disorder. Therefore, understanding the nature of dopamine dysfunction seen in stimulant users has the potential to aid the development of new therapeutics. Objective: To comprehensively review the in vivo imaging evidence for dopaminergic alterations in stimulant (cocaine, amphetamine, or methamphetamine) abuse or dependence...
March 15, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28284948/compulsive-methamphetamine-taking-under-punishment-is-associated-with-greater-cue-induced-drug-seeking-in-rats
#6
Oscar V Torres, Subramanian Jayanthi, Bruce Ladenheim, Michael T McCoy, Irina N Krasnova, Jean Lud Cadet
Methamphetamine (METH) addicts lose control over drug consumption despite suffering multiple adverse medicolegal consequences. To mimic the negative events associated with drug addiction in humans, we recently introduced a rat model of self-administration (SA) with response-contingent punishment on METH intake. These procedures allowed us to distinguish between two addiction-like phenotypes in rats, those that sustained METH taking despite negative consequences (shock-resistant, SR) and rats that significantly reduced their METH intake (shock-sensitive, SS)...
March 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28272095/transcranial-direct-current-stimulation-in-substance-use-disorders-a-systematic-review-of-scientific-literature
#7
Matteo Lupi, Giovanni Martinotti, Rita Santacroce, Eduardo Cinosi, Maria Carlucci, Stefano Marini, Tiziano Acciavatti, Massimo di Giannantonio
INTRODUCTION: New treatment options such as noninvasive brain stimulation have been recently explored in the field of substance use disorders (SUDs), including transcranial direct current stimulation (tDCS). OBJECTIVES: In light of this, we have performed a review of the scientific literature to assess efficacy and technical and methodological issues resulting from applying tDCS to the field of SUDs. METHODS: Our analysis highlighted the following selection criteria: clinical studies on tDCS and SUDs (alcohol, caffeine, cannabis, cocaine, heroin, methamphetamine, and nicotine)...
March 8, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28241493/neuronal-stress-and-injury-caused-by-hiv-1-cart-and-drug-abuse-converging-contributions-to-hand
#8
REVIEW
Ana B Sanchez, Marcus Kaul
Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood...
February 23, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28237710/extended-access-methamphetamine-self-administration-elicits-neuroinflammatory-response-along-with-blood-brain-barrier-breakdown
#9
Joana Gonçalves, Ricardo A Leitão, Alejandro Higuera-Matas, María Amparo Assis, Santiago M Coria, Carlos Fontes-Ribeiro, Emilio Ambrosio, Ana Paula Silva
Methamphetamine (METH) is a highly addictive psychostimulant drug that can lead to neurological and psychiatric abnormalities. Several studies have explored the central impact of METH use, but the mechanism(s) underlying blood-brain barrier (BBB) dysfunction and associated neuroinflammatory processes after chronic METH consumption are still unclear. Important findings in the field are mainly based on in vitro approaches and animal studies using an acute METH paradigm, and not much is known about the neurovascular alterations under a chronic drug use...
February 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28222753/evaluation-of-blood-lead-level-in-methamphetamine-users-in-tehran
#10
Babak Mostafazadeh, Shahin Shadnia, Mohammad Ali Tavakkoli, Hamid Reza Khoddami Vishteh
BACKGROUND: Given the increasing number of lead poisoning in opioids users and since no study has been conducted so far to review lead poisoning in methamphetamine (crystal) users, this study aimed to investigate blood lead level in methamphetamine addicts. METHODS: This study was conducted on 20 patients with methamphetamine poisoning and their blood lead level was measured. The subjects were selected from among patients with a history of continuous use of methamphetamine, without a history of using opiates in the past 6 months confirmed by a negative urine tests, and without a history of heavy metal poisoning...
February 22, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28188005/g-protein-gated-potassium-channels-a-link-to-drug-addiction
#11
REVIEW
Robert A Rifkin, Stephen J Moss, Paul A Slesinger
G protein-gated inwardly rectifying potassium (GIRK) channels are regulators of neuronal excitability in the brain. Knockout mice lacking GIRK channels display altered behavioral responses to multiple addictive drugs, implicating GIRK channels in addictive behaviors. Here, we review the effects of GIRK subunit deletions on the behavioral response to psychostimulants, such as cocaine and methamphetamine. Additionally, exposure of mice to psychostimulants produces alterations in the surface expression of GIRK channels in multiple types of neurons within the reward system of the brain...
February 7, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28181466/microstructures-in-striato-thalamo-orbitofrontal-circuit-in-methamphetamine-users
#12
Yadi Li, Haibo Dong, Feng Li, Gaoyan Wang, Wenhua Zhou, Rongbin Yu, Lingjun Zhang
Background Striato-thalamo-orbitofrontal (STO) circuit plays a key role in the development of drug addiction. Few studies have investigated its microstructural abnormalities in methamphetamine (MA) users. Purpose To evaluate the microstructural changes and relevant clinical relevance of the STO circuit in MA users using diffusion tensor imaging (DTI). Material and Methods Twenty-eight MA users and 28 age-matched normal volunteers were enrolled. 3T magnetic resonance imaging (MRI) was employed to obtain structural T1-weighted (T1W) imaging and diffusion-tensor imaging (DTI) data...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28178893/sexually-transmitted-infection-prevalence-and-related-risk-factors-among-heterosexual-male-methamphetamine-users-in-china
#13
Dianchang Liu, Zhenxia Jiang, Cuizhen Xiu, Zhizhi Li, Qing Song, Zhenhong Wang
Few studies have examined the association between methamphetamine (MA) abuse and sexually transmitted infection (STI) risk among heterosexual male MA users in China. A total of 288 heterosexual male MA users who met our inclusion criteria were recruited from nightclubs, KTVs, bars, bath centres and an STI clinic. STIs were screened among the participants, and the risk factors related to STIs were analysed by multivariate logistic regression in SPSS 11.0. Among the 288 heterosexual male MA users, 51 (17.7%) had syphilis, 36 (12...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28178739/methamphetamine-consumption-during-pregnancy-effects-on-child-health
#14
Jürgen Dinger, Patricia Hinner, Jörg Reichert, Mario Rüdiger
Methamphetamine abuse during pregnancy represents an emerging health care problem. The consequences are not only of relevance to the pregnant women, but also their unborn child. It is associated with an increased risk of preeclampsia and hypertension, fetal demise, preterm delivery, and intrauterine growth restriction. The deleterious effects of prenatal methamphetamine exposure on the developing fetal brain may lead to long-term neuro-developmental and behavioral problems.Given the current evidence, abuse of methamphetamine during pregnancy must be of utmost concern to health care professionals and to policy-makers...
February 8, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28177556/pattern-and-related-factors-of-cognitive-impairment-among-chronic-methamphetamine-users
#15
Tong-Yu Wang, Teng-Teng Fan, Yan-Ping Bao, Xiao-Dong Li, Chun-Mei Liang, Ru-Jia Wang, Jun Ma, Ying Han, Shi-Qiu Meng, Ping Wu, Jie Shi, Lin Lu
BACKGROUND AND OBJECTIVES: Methamphetamine (MA) use is increasingly prevalent in East and Southeast Asia and commonly associated with cognitive impairment. The present study estimated the characteristics of cognitive impairment and explored the associated potential factors among chronic MA users. METHODS: The data were from the baseline visit of a longitudinal study among synthetic drug users. The baseline survey was conducted in detoxification and rehabilitation centers in Guangdong province, China, from September to December in 2013...
March 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28130052/pharmacological-activation-of-the-neurotensin-receptor-1-abrogates-the-methamphetamine-induced-striatal-apoptosis-in-the-mouse-brain
#16
Qingkun Liu, Ariela Hazan, Eddie Grinman, Jesus A Angulo
Methamphetamine (METH) is a widely abused psychostimulant displaying potent addictive and neurotoxic properties. METH induces neurotoxicity of dopaminergic terminals and striatal neurons in the striatum. Despite much information on neurotransmitters, the role of neuropeptides is poorly understood. In this study, we investigated the role of the neuropeptide neurotensin on the METH-induced apoptosis of some striatal neurons in mice. We observed that a single injection of METH (30 mg/kg, ip) induced the loss of approximately 15% of striatal neurons...
January 24, 2017: Brain Research
https://www.readbyqxmd.com/read/28123032/role-of-dorsomedial-striatum-neuronal-ensembles-in-incubation-of-methamphetamine-craving-after-voluntary-abstinence
#17
Daniele Caprioli, Marco Venniro, Michelle Zhang, Jennifer M Bossert, Brandon L Warren, Bruce T Hope, Yavin Shaham
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation. We trained rats to self-administer palatable food pellets (6 d, 6 h/d) and methamphetamine (12 d, 6 h/d). We then assessed relapse to methamphetamine seeking under extinction conditions after 1 and 21 abstinence days. Between tests, the rats underwent voluntary abstinence (using a discrete choice procedure between methamphetamine and food; 20 trials/d) for 19 d...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28110822/oxytocin-acts-in-nucleus-accumbens-to-attenuate-methamphetamine-seeking-and-demand
#18
Brittney M Cox, Brandon S Bentzley, Helaina Regen-Tuero, Ronald E See, Carmela M Reichel, Gary Aston-Jones
BACKGROUND: Evidence indicates that oxytocin, an endogenous peptide well known for its role in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We employed a within-session behavioral-economic (BE) procedure in rats to examine oxytocin as a pharmacotherapy for methamphetamine (meth) addiction. The BE paradigm was modeled after BE procedures used to assess motivation for drugs in humans with addiction. The same BE variables assessed across species have been shown to predict later relapse behavior...
December 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28110353/a-role-for-sigma-receptors-in-stimulant-self-administration-and-addiction
#19
Jonathan L Katz, Takato Hiranita, Weimin C Hong, Martin O Job, Christopher R McCurdy
Sigma receptors (σRs) are structurally unique proteins that function intracellularly as chaperones. Historically, σRs have been implicated as modulators of psychomotor stimulant effects and have at times been proposed as potential avenues for modifying stimulant abuse. However, the influence of ligands for σRs on the effects of stimulants, such as cocaine or methamphetamine, in various preclinical procedures related to drug abuse has been varied. The present paper reviews the effects of σR agonists and antagonists in three particularly relevant procedures: stimulant discrimination, place conditioning, and self-administration...
January 22, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28008351/methamphetamine-addiction-potential-substitute-treatment
#20
Florence Levy
No abstract text is available yet for this article.
December 2016: Therapeutic Advances in Psychopharmacology
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