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https://www.readbyqxmd.com/read/28194935/a-potential-pet-radiotracer-for-the-5-ht2c-receptor-synthesis-and-in-vivo-evaluation-of-4-3-18-f-fluorophenethoxy-pyrimidine
#1
Juhyeon Kim, Byung Seok Moon, Byung Chul Lee, Ho-Young Lee, Hak Joong Kim, Hyunah Choo, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min
The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT receptor widely distributed throughout the central nerve system. As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine and -aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety. Up to date, three kinds of 5-HT2C PET radiotracers such as [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2), [18F]fluorophenylcyclopropane (3) have been developed, but they may not be suitable for in vivo 5-HT2C imaging study due to their modest specific binding...
February 14, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28165152/memory-errors-in-alibi-generation-how-an-alibi-can-turn-against-us
#2
William E Crozier, Deryn Strange, Elizabeth F Loftus
Alibis play a critical role in the criminal justice system. Yet research on the process of alibi generation and evaluation is still nascent. Indeed, similar to other widely investigated psychological phenomena in the legal system - such as false confessions, historical claims of abuse, and eyewitness memory - the basic assumptions underlying alibi generation and evaluation require closer empirical scrutiny. To date, the majority of alibi research investigates the social psychological aspects of the process...
February 6, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28161446/drunk-bugs-chronic-vapour-alcohol-exposure-induces-marked-changes-in-the-gut-microbiome-in-mice
#3
Veronica L Peterson, Nicholas J Jury, Raúl Cabrera-Rubio, Lorraine A Draper, Fiona Crispie, Paul D Cotter, Timothy G Dinan, Andrew Holmes, John F Cryan
The gut microbiota includes a community of bacteria that play an integral part in host health and biological processes. Pronounced and repeated findings have linked gut microbiome to stress, anxiety, and depression. Currently, however, there remains only a limited set of studies focusing on microbiota change in substance abuse, including alcohol use disorder. To date, no studies have investigated the impact of vapour alcohol administration on the gut microbiome. For research on gut microbiota and addiction to proceed, an understanding of how route of drug administration affects gut microbiota must first be established...
February 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28156433/psychosocial-distress-screening-in-the-health-care-safety-net
#4
Theora Cimino, Anne Kinderman, Leslie Safier, Heather A Harris
: 91 Background: Recognizing that psychosocial distress (PSD) is underestimated in patients with cancer, the Commission on Cancer mandated screening using a validated tool. Studies of PSD screening exist, but none to date in a diverse, multicultural safety net setting where patients face challenges such as homelessness, mental illness, and substance abuse, which may augment PSD. METHODS: We performed a retrospective cohort study of patients with cancer offered PSD screening during 2015...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139252/childhood-sexual-abuse-sexual-motives-and-adolescent-sexual-risk-taking-among-males-and-females-receiving-child-welfare-services
#5
Christine Wekerle, Abby L Goldstein, Masako Tanaka, Lil Tonmyr
Childhood sexual abuse (CSA) is associated with multiple negative outcomes, including increased risky sexual behavior. To date, the majority of research on the relationship between CSA and risky sex in adolescence has been limited, with a lack of focus on males and youth receiving child welfare services. Participants in the current study were 297 youth (mean age=15.98; SD=1.01, 57.6% female) from the child welfare system who reported being sexually active at the time of the survey. CSA was associated with severity of other types of maltreatment for both genders, and exposure to intimate partner violence for females only...
January 27, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28138269/utilization-of-dating-apps-by-men-who-have-sex-with-men-for-persuading-other-men-toward-substance-use
#6
Smith Boonchutima, Watsayut Kongchan
BACKGROUND: Dating apps play a major role in connecting men who are interested in meeting other men for sex. Besides finding a partner, these tools are also exploited for other activities such as encouraging people to get involved in the habit of illicit drug consumption (substance use). METHODS: This study evaluated the overall usage of dating apps among Thai men who have sex with men (MSMs), with an emphasis on abusing these apps to convey messages encouraging substance use...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28130957/immunoassay-screening-in-urine-for-synthetic-cannabinoids-an-evaluation-of-the-diagnostic-efficiency
#7
Florian Franz, Verena Angerer, Hanna Jechle, Melanie Pegoro, Harald Ertl, Georg Weinfurtner, David Janele, Christian Schlögl, Matthias Friedl, Stefan Gerl, Reinhard Mielke, Ralf Zehnle, Matthias Wagner, Bjoern Moosmann, Volker Auwärter
BACKGROUND: The abuse of synthetic cannabinoids (SCs) as presumed legal alternative to cannabis poses a great risk to public health. For economic reasons many laboratories use immunoassays (IAs) to screen for these substances in urine. However, the structural diversity and high potency of these designer drugs places high demands on IAs regarding cross-reactivity of the antibodies used and detection limits. METHODS: Two retrospective studies were carried out in order to evaluate the capability of two homogenous enzyme IAs for the detection of currently prevalent SCs in authentic urine samples...
January 28, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28130893/perceptions-of-psychological-abuse-versus-physical-abuse-and-their-relationship-with-mental-health-outcomes
#8
B S Sandra F Masci, Sonya Sanderson
Prior research has been limited in examining at what degree aggressive actions are initially perceived negatively. Thepresent research examined whether anxiety, depression, and posttraumatic stress disorder (PTSD) symptoms were associated with prior abuse or with being attributed to past or present relationships. Scales such as the Dating Relationship Profile (DRP) and hypothetical scenarios of abuse perpetration were used. This study hypothesized that acceptability ratings from hypothetical scenarios would predict answers on DRP items measuring whether physical or psychological abuse is considered acceptable in relationships...
January 27, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28126359/spanking-and-adult-mental-health-impairment-the-case-for-the-designation-of-spanking-as-an-adverse-childhood-experience
#9
Tracie O Afifi, Derek Ford, Elizabeth T Gershoff, Melissa Merrick, Andrew Grogan-Kaylor, Katie A Ports, Harriet L MacMillan, George W Holden, Catherine A Taylor, Shawna J Lee, Robbyn Peters Bennett
Adverse Childhood Experiences (ACEs) such as child abuse are related to poor health outcomes. Spanking has indicated a similar association with health outcomes, but to date has not been considered an ACE. Physical and emotional abuse have been shown in previous research to correlate highly and may be similar in nature to spanking. To determine if spanking should be considered an ACE, this study aimed to examine 1): the grouping of spanking with physical and emotional abuse; and 2) if spanking has similar associations with poor adult health problems and accounts for additional model variance...
January 23, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28115073/predatory-open-access-in-rehabilitation
#10
Andrea Manca, Gianluca Martinez, Lucia Cugusi, Daniele Dragone, Giuseppe Mercuro, Franca Deriu
Increasingly scholars and researchers are being solicited by predatory "open access" journals seeking manuscript submissions and abusing the author-pays model by charging authors with publishing fees without any or proper peer review. Such questionable editorial practices are threatening the reputation and credibility of scholarly publishing. To date no investigation has been conducted on this phenomenon in the field of rehabilitation. The present study attempts to identify specific predatory journals operating in this field, to quantify the phenomenon and its geographical distribution...
January 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28110353/a-role-for-sigma-receptors-in-stimulant-self-administration-and-addiction
#11
Jonathan L Katz, Takato Hiranita, Weimin C Hong, Martin O Job, Christopher R McCurdy
Sigma receptors (σRs) are structurally unique proteins that function intracellularly as chaperones. Historically, σRs have been implicated as modulators of psychomotor stimulant effects and have at times been proposed as potential avenues for modifying stimulant abuse. However, the influence of ligands for σRs on the effects of stimulants, such as cocaine or methamphetamine, in various preclinical procedures related to drug abuse has been varied. The present paper reviews the effects of σR agonists and antagonists in three particularly relevant procedures: stimulant discrimination, place conditioning, and self-administration...
January 22, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28110108/boys-are-not-exempt-sexual-exploitation-of-adolescents-in-sub-saharan-africa
#12
Jones K Adjei, Elizabeth M Saewyc
Research on youth sexual exploitation in Africa has largely neglected the experiences of exploited boys. To date, much of the research in sub-Saharan Africa continues to consider boys mainly as exploiters but not as exploited. Using the only publicly available population-based surveys from the National Survey of Adolescents, conducted in four sub-Saharan African countries - Burkina Faso, Ghana, Malawi, and Uganda-we assessed factors associated with transactional sexual behaviour among never-married adolescent boys and girls...
January 18, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28099107/case-238-spontaneous-pneumothorax-secondary-to-intrapulmonary-necrobiotic-rheumatoid-nodule
#13
Ammar A Chaudhry, Maryam Gul, Abbas A Chaudhry, William Moore
History A 54-year-old white woman with a history of rheumatoid arthritis who was taking glucocorticoids and methotrexate presented to the emergency department in December with worsening shortness of breath and chest heaviness for 1 week. She reported additional symptoms of weakness, headache, and arthralgia primarily involving her bilateral hands, wrist, ankles, and feet. She denied experiencing fevers, syncope or presyncope, focal neurologic deficits, chest pain, nausea, vomiting, unintentional weight loss, or recent trauma...
February 2017: Radiology
https://www.readbyqxmd.com/read/28087129/childhood-maltreatment-and-unprotected-sex-among-female-juvenile-offenders-evidence-of-mediation-by-substance-abuse-and-psychological-distress
#14
Kristen Clements-Nolle, Sandra Larson, Aliya Buttar, Lindsey Dermid-Gray
PURPOSE: Research has shown that childhood maltreatment is associated with sexual risk taking among female juvenile offenders; however, the mechanisms by which maltreatment influences sexual risk remain poorly understood. We assessed whether substance abuse, psychological distress, and dating violence mediate the relationship between childhood maltreatment and unprotected sex. METHODS: Sexually active female juvenile offenders (13-17 years of age) completed audio computer-assisted self-interviews (n = 232)...
January 10, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28073687/adverse-event-detection-using-the-fda-post-marketing-drug-safety-surveillance-system-cardiotoxicity-associated-with-loperamide-abuse-and-misuse
#15
Kimberley A Swank, Eileen Wu, Cindy Kortepeter, Jana McAninch, Robert L Levin
OBJECTIVE: The purpose of this investigation was to identify and characterize post-marketing reports of cardiotoxicity, including torsades de pointes (TdP), associated with loperamide use. METHODS: We searched the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database for post-marketing reports of serious cardiac adverse events associated with loperamide use from December 28, 1976 (U.S. drug approval date), through December 14, 2015. We also conducted a Pubmed and Google Scholar search to identify additional published reports of cardiotoxicity associated with loperamide in the medical literature through February 11, 2016...
January 7, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28069620/prenatal-exposure-to-antiepileptic-drugs-and-use-of-primary-healthcare-during-childhood-a-population-based-cohort-study-in-denmark
#16
Anne Mette Würtz, Dorte Rytter, Claus Høstrup Vestergaard, Jakob Christensen, Mogens Vestergaard, Bodil Hammer Bech
OBJECTIVE: Prenatal exposure to antiepileptic drugs (AEDs) has been associated with adverse outcomes in the offspring such as congenital malformations and neuropsychiatric disorders. The objective of this study was to investigate whether prenatal exposure to AEDs is also associated with more frequent use of primary healthcare during childhood. DESIGN: Population-based cohort study. SETTING: Nationwide national registers in Denmark. PARTICIPANTS: All live-born singletons in Denmark during 1997-2012 identified in the Danish National Patient Register and followed until 31 December 2013 (n=963 010)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28063587/indirect-chiral-separation-of-8-novel-amphetamine-derivatives-as-potential-new-psychoactive-compounds-by-gc-ms-and-hplc
#17
Jennifer A Weiß, Kian Kadkhodaei, Martin G Schmid
Amphetamine and its derivatives gained high popularity on the illegal drug market. In the last few years, a lot of new psychoactive compounds structurally related to amphetamine, such as 4-fluoroamphetamine and 4-fluoromethamphetamine swamped the drug market. They were designed to circumvent prohibition of amphetamine and N-methylamphetamine and are distributed via the Internet. Often, a halogen atom is introduced into the phenyl ring of amphetamine to turn the illegal amphetamine legal. Since amphetamines possess a chiral centre, two enantiomers are available, which might differ in activity...
January 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28058249/microbiological-and-chemico-physical-shelf-life-and-panel-test-to-evaluate-acceptability-of-liver-mortadella
#18
Erica Tirloni, Simone Stella, Cristian Bernardi, Vittorio Maria Moretti, Carla Bersani, Patrizia Cattaneo
This study aimed to evaluate the shelf life of sliced cooked liver mortadella packaged in MAP (70-85% N2, 15-30% CO2) and stored in refrigeration (4°C) or slight thermal abuse (8°C) for up to 49 days (declared best before date 45 days). The proximate composition, aw nitrites and NaCl content were determined at T0. Weekly, samples were submitted to microbiological [total viable count (TVC), lactic acid bacteria (LAB), Enterobacteriaceae, Escherichia coli, Pseudomonas spp., coagulase positive staphylococci, sulphite reducing clostridia, yeasts and moulds, Listeria monocytogenes and Salmonella spp...
September 20, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/28054214/the-association-between-historical-childhood-sexual-abuse-and-later-parenting-stress-a-systematic-review
#19
REVIEW
Melanie Hugill, Katherine Berry, Ian Fletcher
An individual's own experiences of childhood and being parented are likely to be key determinants of their later parenting experiences. Childhood sexual abuse (CSA) is arguably the most toxic experience to occur in childhood and therefore may be particularly likely to impact on parenting stress in the context of parenting one's own children. This paper aims to review studies investigating associations between earlier CSA and later parenting to determine the size and consistency of the effects, identify any mediators and moderators of the relationship, and assess the quality of the evidence base...
January 4, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28029437/the-nature-and-extent-of-police-use-of-force-in-encounters-with-people-with-behavioral-health-disorders
#20
Melissa S Morabito, Kelly Socia, Amanda Wik, William H Fisher
Previous research studies have examined the treatment of people with mental illnesses by the police. Much available data support the adoption of the Crisis Intervention Team (CIT) model. A key issue in CIT development has been reduction in the use of force by CIT officers, and it is suggested that such adoption does accomplish such reduction. However, to date, scant research compares variation in police use of force by CIT officers across populations with mental illnesses, co-occurring disorders, and substance abuse disorders, as compared to their non-disordered peers...
October 28, 2016: International Journal of Law and Psychiatry
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