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https://www.readbyqxmd.com/read/27911219/anxiety-mediates-the-relation-between-childhood-sexual-abuse-and-genito-pelvic-pain-in-adolescent-girls
#1
Marie Santerre-Baillargeon, Pascale Vézina-Gagnon, Isabelle Daigneault, Tina Landry, Sophie Bergeron
Previous research has demonstrated associations between child sexual abuse, anxiety and genito-pelvic pain, but no study to date has examined whether sexual abuse may be associated with genito-pelvic pain through victims' elevated anxiety. The present study aimed to determine whether anxiety mediates the relationship between child sexual abuse and genito-pelvic pain. Using self-report questionnaires, data were gathered from 218 sexually active adolescent girls recruited from seven metropolitan high schools...
December 2, 2016: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/27909991/the-role-of-orexins-hypocretins-in-alcohol-use-and-abuse
#2
Leigh C Walker, Andrew J Lawrence
Addiction is a chronic relapsing disorder characterized by compulsive drug seeking and drug taking despite negative consequences. Alcohol abuse and addiction have major social and economic consequences and cause significant morbidity and mortality worldwide. Currently available therapeutics are inadequate, outlining the need for alternative treatments. Detailed knowledge of the neurocircuitry and brain chemistry responsible for aberrant behavior patterns should enable the development of novel pharmacotherapies to treat addiction...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27908258/neurotoxicity-induced-by-mephedrone-an-up-to-date-review
#3
Flaminia Pantano, Roberta Tittarelli, Giulio Mannocchi, Roberta Pacifici, Alessandro di Luca, Francesco Paolo Busardò, Enrico Marinelli
Mephedrone is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential. The aim of this review was to examine the emerging scientific literature on the possible mephedrone-induced neurotoxicity, yet not well defined due to the limited number of experimental studies, mainly carried on animal models. Relevant scientific articles were identified from international literature databases (Medline, Scopus, etc...
November 30, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27889367/use-or-abuse-a-qualitative-study-of-emergency-physicians-views-on-use-of-observation-stays-at-three-hospitals-in-the-united-states-and-england
#4
Graham P Martin, Brad Wright, Azeemuddin Ahmed, Jay Banerjee, Suzanne Mason, Damian Roland
STUDY OBJECTIVE: Accumulating evidence has shown increasing use of observation stays for patients presenting to emergency departments and requiring diagnostic evaluation or time-limited treatment plans, but critics suggest that this expansion arises from hospitals' concerns to maximize revenue and shifts costs to patients. Perspectives of physicians making decisions to admit, observe, or discharge have been absent from the debate. We examine the views of emergency physicians in the United States and England on observation stays, and what influences their decisions to use observation services...
November 23, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27885972/protecting-the-confidentiality-and-security-of-personal-health-information-in-low-and-middle-income-countries-in-the-era-of-sdgs-and-big-data
#5
Eduard J Beck, Wayne Gill, Paul R De Lay
BACKGROUND: As increasing amounts of personal information are being collected through a plethora of electronic modalities by statutory and non-statutory organizations, ensuring the confidentiality and security of such information has become a major issue globally. While the use of many of these media can be beneficial to individuals or populations, they can also be open to abuse by individuals or statutory and non-statutory organizations. Recent examples include collection of personal information by national security systems and the development of national programs like the Chinese Social Credit System...
2016: Global Health Action
https://www.readbyqxmd.com/read/27884751/a-systematic-review-of-the-effect-of-cannabidiol-on-cognitive-function-relevance-to-schizophrenia
#6
REVIEW
Ashleigh L Osborne, Nadia Solowij, Katrina Weston-Green
BACKGROUND AND OBJECTIVES: Cognitive impairment is a core symptom domain of schizophrenia, neurological disorders and substance abuse. It is characterised by deficits in learning, memory, attention and executive functioning and can severely impact daily living. Antipsychotic drugs prescribed to treat schizophrenia provide limited cognitive benefits and novel therapeutic targets are required. Cannabidiol (CBD), a component of the cannabis plant, has anti-inflammatory and antipsychotic-like properties; however, its ability to improve cognitive impairment has not been thoroughly explored...
November 21, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27881163/assessing-the-feasibility-of-a-web-based-domestic-violence-intervention-using-chronic-disease-frameworks-reducing-the-burden-of-treatment-and-promoting-capacity-for-action-in-women-abused-by-a-partner
#7
Laura Tarzia, Carl May, Kelsey Hegarty
BACKGROUND: Domestic violence shares many features with chronic disease, including ongoing physical and mental health problems and eroded self-efficacy. Given the challenges around help-seeking for women experiencing domestic violence, it is essential that they be given support to 'self-manage' their condition. The growing popularity of web-based applications for chronic disease self-management suggests that there may be opportunities to use them as an intervention strategy for women experiencing domestic violence, however, as yet, little is known about whether this might work in practice...
November 24, 2016: BMC Women's Health
https://www.readbyqxmd.com/read/27874725/impact-of-perpetrator-type-on-attributions-of-mother-fault-in-child-sexual-abuse
#8
Jessica L Zagrodney, Jorden A Cummings
Blaming nonoffending mothers for child sexual abuse has substantial negative consequences for both the mother and child victim. Although perpetrator type has been shown to influence how much blame and responsibility is placed on nonoffending mothers in child sexual abuse cases, research to date has focused primarily on perpetrators who are strangers to the child or the child's biological father, ignoring the effect of other father-figure perpetrators. The current study examined how differences in perpetrator's relationship to the mother impacted blame, responsibility, cause, and prevention as separate constructs...
November 2016: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/27871957/tramadol-abuse-and-sexual-function
#9
REVIEW
Ibrahim A Abdel-Hamid, Karl-Erik Andersson, Marcel D Waldinger, Tarek H Anis
INTRODUCTION: Tramadol exhibits an effect profile similar to that of opioid agonists, and tramadol abuse seems to be a problem for a number of countries. The relationship between tramadol and sexual function appears to be controversial. Men with premature ejaculation (PE) may benefit from taking tramadol off label; however, these patients live "on a knife's edge" and are exquisitely sensitive to develop other sexual dysfunctions. AIM: To review the literature regarding the problem of tramadol abuse and its relationship with sexual function...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27865607/dna-modifications-in-models-of-alcohol-use-disorders
#10
REVIEW
Christopher T Tulisiak, R Adron Harris, Igor Ponomarev
Chronic alcohol use and abuse result in widespread changes to gene expression, some of which contribute to the development of alcohol use disorders (AUD). Gene expression is, in part, controlled by a group of regulatory systems often referred to as epigenetic factors, which includes, among other mechanisms, chemical marks made on the histone proteins around which genomic DNA is wound to form chromatin, and on nucleotides of the DNA itself. In particular, alcohol has been shown to perturb the epigenetic machinery, leading to changes in gene expression and cellular functions characteristic of AUD and, ultimately, to altered behavior...
November 9, 2016: Alcohol
https://www.readbyqxmd.com/read/27849478/qualitative-inquiry-explores-health-related-quality-of-life-of-female-veterans-with-post-traumatic-stress-disorder
#11
Jolie N Haun, Allyson Duffy, Jason D Lind, Pamela Kisala, Stephen L Luther
As the number of female veterans increases, health care systems must be prepared to meet the individualized needs of this population. To date, published data on health-related quality of life (HRQOL) of veterans with post-traumatic stress disorder (PTSD) focus on quantitative data and primarily represent the male population. The purpose of this study was to qualitatively explore the impact of PTSD on female veterans' HRQOL. A descriptive qualitative study used focus groups and demographic surveys to achieve data collection in a sample of veterans with PTSD...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27848217/pregabalin-for-the-treatment-of-drug-and-alcohol-withdrawal-symptoms-a-comprehensive-review
#12
REVIEW
Rainer Freynhagen, Miroslav Backonja, Stephan Schug, Gavin Lyndon, Bruce Parsons, Stephen Watt, Regina Behar
Treatments for physical dependence and associated withdrawal symptoms following the abrupt discontinuation of prescription drugs (such as opioids and benzodiazepines), nicotine, alcohol, and cannabinoids are available, but there is still a need for new and more effective therapies. This review examines evidence supporting the potential use of pregabalin, an α2δ voltage-gated calcium channel subunit ligand, for the treatment of physical dependence and associated withdrawal symptoms. A literature search of the MEDLINE and Cochrane Library databases up to and including 11 December 2015 was conducted...
November 16, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27832780/public-responses-to-the-sharing-and-linkage-of-health-data-for-research-purposes-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#13
Mhairi Aitken, Jenna de St Jorre, Claudia Pagliari, Ruth Jepson, Sarah Cunningham-Burley
BACKGROUND: The past 10 years have witnessed a significant growth in sharing of health data for secondary uses. Alongside this there has been growing interest in the public acceptability of data sharing and data linkage practices. Public acceptance is recognised as crucial for ensuring the legitimacy of current practices and systems of governance. Given the growing international interest in this area this systematic review and thematic synthesis represents a timely review of current evidence...
November 10, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27832341/non-accidental-trauma-the-role-of-radiology
#14
Cory M Pfeifer, Matthew R Hammer, Kate L Mangona, Timothy N Booth
Non-accidental trauma is a significant source of morbidity and mortality in the pediatric population. Given the vulnerable state of the child, the radiologist can often provide valuable diagnostic information in the setting of suspected abuse. This review focuses on common findings of abusive trauma and serves as a guide to aid in clinical decision-making for providers of emergency medicine and pediatrics. Amid this discussion is an assessment of modern controversies regarding reported mimicking pathologies, recapitulation of the current state of evidence with respect to radiologic findings of abuse, and examination of the contribution that spine imaging may add to the diagnosis of possible abusive head trauma in the acutely injured child...
November 10, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27832068/time-dependent-changes-in-t1-during-fracture-healing-in-juvenile-rats-a-quantitative-mr-approach
#15
Katharina Baron, Bernhard Neumayer, Eva Amerstorfer, Eva Scheurer, Clemens Diwoky, Rudolf Stollberger, Hanna Sprenger, Annelie M Weinberg
Quantitative magnetic resonance imaging (qMRI) offers several advantages in imaging and determination of soft tissue alterations when compared to qualitative imaging techniques. Although applications in brain and muscle tissues are well studied, its suitability to quantify relaxation times of intact and injured bone tissue, especially in children, is widely unknown. The objective observation of a fracture including its age determination can become of legal interest in cases of child abuse or maltreatment. Therefore, the aim of this study is the determination of time dependent changes in intact and corresponding injured bones in immature rats via qMRI, to provide the basis for an objective and radiation-free approach for fracture dating...
2016: PloS One
https://www.readbyqxmd.com/read/27807640/do-high-school-students-in-india-gamble-a-study-of-problem-gambling-and-its-correlates
#16
T S Jaisoorya, K V Beena, M Beena, K Ellangovan, K Thennarassu, Henrietta Bowden-Jones, Vivek Benegal, Sanju George
Studies from the West suggest that significant numbers of high school students gamble, despite it being illegal in this age group. To date, there have been no studies on the prevalence of gambling among senior high school and higher secondary school students in India. This study reports point prevalence of gambling and its psychosocial correlates among high school students in the State of Kerala, India. 5043 high school students in the age group 15-19 years, from 73 schools, were selected by cluster random sampling from the district of Ernakulam, Kerala, South India...
November 2, 2016: Journal of Gambling Studies
https://www.readbyqxmd.com/read/27807208/the-golden-thread-coercive-control-and-risk-assessment-for-domestic-violence
#17
Andy Myhill, Katrin Hohl
Research on risk assessment for domestic violence has to date focused primarily on the predictive power of individual risk factors and the statistical validity of risk assessment tools in predicting future physical assault in sub-sets of cases dealt with by the police. This study uses data from risk assessment forms from a random sample of cases of domestic violence reported to the police. An innovative latent trait model is used to test whether a cluster of risk factors associated with coercive control is most representative of the type of abuse that comes to the attention of the police...
November 1, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27789611/reviewing-the-focus-a-summary-and-critique-of-child-focused-sexual-abuse-prevention
#18
Julia Rudolph, Melanie J Zimmer-Gembeck
Due to the high incidence, and widespread detrimental health consequences, of child sexual abuse (CSA), effective prevention remains at the forefront of public and mental health research, prevention and intervention agendas. To date much of the focus of prevention has been on school-based education programs designed to teach children skills to evade adult sexual advances, and disclose past or ongoing abuse. Evaluation of sexual abuse prevention programs demonstrate their effectiveness in increasing children's knowledge of CSA concepts and protection skills, but little is known about their effects on children's capacity to prevent abuse...
October 26, 2016: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/27786595/cocaine-mediated-downregulation-of-microglial-mir-124-expression-involves-promoter-dna-methylation
#19
Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Yeon Hee Kook, Fang Niu, Shannon E Callen, Shilpa Buch
Neuroinflammation plays a critical role in the development of reward-related behavior in cocaine self-administration rodents. Cocaine, one of most commonly abused drugs, has been shown to activate microglia both in vitro and in vivo. Detailed molecular mechanisms underlying cocaine-mediated microglial activation remain poorly understood. microRNAs (miRs), belonging to a class of small noncoding RNA superfamily have been shown to modulate the activation status of microglia. miR-124, one of the microglia-enriched miRs, functions as an anti-inflammatory regulator that maintains microglia in a quiescent state...
October 27, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27760572/maternal-abuse-history-and-reduced-fetal-heart-rate-variability-abuse-related-sleep-disturbance-is-a-mediator
#20
Hanna Gustafsson, Colleen Doyle, Michelle Gilchrist, Elizabeth Werner, Catherine Monk
The consequences of childhood maltreatment are profound and long lasting. Not only does the victim of abuse suffer as a child, but there is mounting evidence that a history of maltreatment places the next generation at risk for significant psychopathology. Research identifies postnatal factors as affecting this intergenerational transmission of trauma. However, emerging evidence suggests that part of this risk may be transmitted before birth, passed on via abuse-related alterations in the in utero environment that are as yet largely unidentified...
October 20, 2016: Development and Psychopathology
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