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https://www.readbyqxmd.com/read/29219862/when-can-we-predict-the-outcome-of-an-electroconvulsive-therapy-course-in-adolescents-a-retrospective-study
#1
Hagai Maoz, Uri Nitzan, Yiftach Goldwyn, Israel Krieger, Yuval Bloch
OBJECTIVE: There is a dearth of up-to-date literature regarding electroconvulsive therapy (ECT) in adolescents, and the question of when to pronounce course failure has not been properly addressed. The current study aims to evaluate trajectories of clinical status throughout ECT courses in adolescent patients. METHODS: We retrieved detailed data of 36 patients who received ECT in our treatment center. Clinical records were retrospectively assessed and evaluated every 6 ECT sessions to quantify Clinical Global Impressions-Improvement (CGI-I) scores...
December 6, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29218780/under-treatment-of-hypertension-and-hypercholesterolemia-in-children-and-adolescents-with-type-1-diabetes-long-term-follow-up-on-time-trends-in-the-occurrence-of-cardiovascular-disease-risk-factors-and-medications-use
#2
Fariba Ahmadizar, Patrick Souverein, Anthonius de Boer, Anke H Maitland-van der Zee
AIMS: 1) To evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and occurrence of CVD events in children with type 1 diabetes mellitus (T1DM), and 2) To assess determinants of under-treatment of CVD risk factors. METHODS: A retrospective cohort study was conducted in 3,728 children (<19 years) with T1DM and up to 5 age and gender-matched diabetes-free children (reference cohort) (n=18,513) using data from the Clinical Practice Research Datalink (CPRD)...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29213221/omalizumab-in-children-with-severe-allergic-asthma-the-italian-real-life-experience
#3
Amelia Licari, Riccardo Castagnoli, Chiara Denicolò, Linda Rossini, Manuela Seminara, Lucia Sacchi, Giorgia Testa, Mara De Amici, Gian Luigi Marseglia
Background: Anti-IgE treatment represents a major breakthrough in the therapeutic management of severe allergic asthma. To date, omalizumab is the only biological drug currently licensed as add-on therapy in children aged > 6 years with moderate-to-severe and severe allergic asthma uncontrolled after treatment with high dose of inhaled corticosteroids plus long-acting inhaled beta2-agonist. The clinical efficacy and safety of omalizumab treatment in the pediatric population has been extensively documented in specific trials and consistently expanded from real-life studies...
March 2017: Current Respiratory Medicine Reviews
https://www.readbyqxmd.com/read/29213218/tiotropium-in-asthma-back-to-the-future-of-anticholinergic-treatment
#4
REVIEW
Matteo Bonini, Nicola Scichilone
Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic agents...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29212731/clinical-activity-of-pazopanib-in-patients-with-advanced-desmoplastic-small-round-cell-tumor
#5
Brian A Menegaz, Branko Cuglievan, Jalen Benson, Pamela Camacho, Salah-Eddine Lamhamedi-Cherradi, Cheuk Hong Leung, Carla L Warneke, Winston Huh, Vivek Subbiah, Robert S Benjamin, Shreyaskumar Patel, Najat Daw, Andrea Hayes-Jordan, Joseph A Ludwig
BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is an aggressive, often fatal soft tissue sarcoma that lacks an optimal salvage regimen. We retrospectively reviewed data from 29 pretreated DSRCT patients who received pazopanib at MD Anderson Cancer Center after failure of standard chemotherapies. SUBJECTS, MATERIALS, AND METHODS: Medical records of patients treated from January 2012 to December 2016 were reviewed and regression analyses were performed. Median progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan-Meier method and differences in survival were assessed by a log-rank test...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29211870/osteonecrosis-of-the-jaw-and-rebound-hypercalcaemia-in-young-people-treated-with-denosumab-for-giant-cell-tumour-of-bone
#6
Suma Uday, Louie Gaston, Luke Rogers, Michael Parry, Johnathan Joffe, John Pearson, David Sutton, Robert Grimer, Wolfgang Högler
Context: Denosumab, an inhibitor of receptor activator of nuclear factor kappa-B ligand, is an approved treatment for giant cell tumour of bone (GCTB) in adults and 'skeletally mature' adolescents. Safety concerns include oversuppression of bone remodelling, with risk of osteonecrosis of the jaw [ONJ] and atypical femur fractures during treatment in adults, and rebound hypercalcaemia after treatment cessation in children. To date, ONJ has never been reported in children or adolescents...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29209144/targeting-the-long-noncoding-rna-malat1-blocks-the-pro-angiogenic-effects-of-osteosarcoma-and-suppresses-tumour-growth
#7
Zhi-Chang Zhang, Chun Tang, Yang Dong, Jing Zhang, Ting Yuan, Shi-Cong Tao, Xiao-Lin Li
Osteosarcoma (OS), the commonest primary malignant tumour originating from bone, affects a substantial number of people, mostly during adolescent growth, and leads to a very poor prognosis as a result of the high rate of early metastases. Consequently, there is urgent demand for a novel treatment for this disease. There are growing concerns focused on OS-induced pro-angiogenic effects, but to date, the mechanism of OS-induced pro-angiogenesis is still insufficiently well-understood. Long noncoding RNAs (lncRNAs) have attracted increasing interest due to their strong correlation with a variety of diseases and their powerful capacity for epigenetic regulation...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29207976/demographic-differences-in-and-correlates-of-perceived-body-image-discrepancy-among-urban-adolescent-girls-a-cross-sectional-study
#8
Lorraine B Robbins, Jiying Ling, Kenneth Resnicow
BACKGROUND: Understanding factors related to girls' body image discrepancy, which is the difference between self-perceived current or actual and ideal body size, is important for addressing body-related issues and preventing adverse sequelae. Two aims were to: 1) examine demographic differences in body image discrepancy; and 2) determine the association of body image discrepancy with weight status, percent body fat, physical activity, sedentary behavior, and cardiovascular (CV) fitness among young adolescent girls...
December 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29207962/a-partially-supervised-physical-activity-program-for-adult-and-adolescent-survivors-of-childhood-cancer-surfit-study-design-of-a-randomized-controlled-trial-nct02730767
#9
Corina S Rueegg, Susi Kriemler, Simeon J Zuercher, Christina Schindera, Andrea Renner, Helge Hebestreit, Christian Meier, Prisca Eser, Nicolas X von der Weid
BACKGROUND: Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today's survivors suffer from short- and long-term adverse effects such as cardiovascular and pulmonary diseases, obesity, osteoporosis, fatigue, depression, and reduced physical fitness and quality of life. Regular exercise can play a major role to mitigate or prevent such late-effects. Despite this, there are no data on the effects of regular exercise in childhood cancer survivors from randomized controlled trials (RCTs)...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29206823/-thoracic-and-lumbar-fractures-in-adolescents-an-eight-year-study
#10
Félix Adolfo Sánchez-Chávez, Jorge Arturo Cabrera-Escamilla
METHODS: In order to know the characteristics of these lesions in our environment and compare with those the adults, a transversal and descriptive study of adolescents between 12 and 18 years who were hospitalized for thoracic and lumbar fracture in two centers of high level trauma in our country for 8 years was performed. The variables studied were applied statistical analysis descriptive and correlation. RESULTS: They were found significant date by associating the causes of damage with associated lesions (p = 0...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29200174/predictability-of-supine-radiographs-for-determining-in-brace-correction-for-adolescent-idiopathic-scoliosis
#11
Jason Pui Yin Cheung, Karen Kar Lum Yiu, Srinivasa Vidyadhara, Peggy Pui Yee Chan, Prudence Wing Hang Cheung, Kin Cheung Mak
STUDY DESIGN: Retrospective radiographic study OBJECTIVE.: To assess whether flexibility as revealed by the supine radiograph, predicts in-brace curve correction. SUMMARY OF BACKGROUND DATA: Currently there is no consensus regarding a standard method to assess curve flexibility and immediate brace effectiveness in treating adolescent idiopathic scoliosis (AIS). Brace fabrication methods may be variable but ideally it should achieve maximal curve correction. Curve flexibility governs the degree of curve correction in-brace and hence dynamic radiographs are commonly performed prior to brace fitting...
December 1, 2017: Spine
https://www.readbyqxmd.com/read/29195632/parents-involvement-in-the-human-papillomavirus-vaccination-decision-for-their-sons
#12
Samara Perez, Hannah Restle, Anila Naz, Ovidiu Tatar, Gilla K Shapiro, Zeev Rosberger
OBJECTIVES: Parents are critical to ensure sufficient human papillomavirus (HPV) vaccine coverage. No studies to date have examined how mothers and fathers perceive their own, their partners' and their sons' involvement in HPV vaccination decision-making process. METHODS: An online survey methodology was used to collect data from a national sample of Canadian parents (33% fathers, 67% mothers, Mage=44) who had a 9-16years old son (n=3117). MAIN OUTCOME MEASURES: Parent's perception of their self-involvement, partner-involvement and son's involvement in the decision to get their son the HPV vaccine were measured on a Likert scale and were classified as 'no involvement', 'moderate involvement' and 'high involvement'...
December 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/29192872/experience-of-being-young-with-psoriasis-self-management-support-needs
#13
Gitte Susanne Rasmussen, Knud Kragballe, Helle Terkildsen Maindal, Kirsten Lomborg
Psoriasis is a long-term condition with a possibly cumulative life course impairment. Young people struggle to minimize its effects on appearance and functioning. To date, the self-management needs of adolescents suffering from psoriasis have been underinvestigated. Using focus groups and individual interviews, we present an interpretive description of young people's experiences of living with psoriasis, the challenges they face, and the support they need to relieve suffering and come to terms with their condition...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29189538/what-s-new-in-pediatric-sports-conditions-of-the-knee
#14
Aristides I Cruz, Connor G Richmond, Marc A Tompkins, Ann Heyer, Kevin G Shea, Jennifer J Beck
BACKGROUND: Sports injuries are common in pediatric and adolescent patients and the evaluation and treatment of these injuries continues to evolve. The purpose of this review is to provide a comprehensive appraisal of the literature, highlighting recent updates on sports-related knee injuries in the pediatric athlete. We specifically examined literature on tibial spine fractures, osteochondritis dissecans (OCD) of the knee, and patellar instability. Because of the volume of literature on the subject, pediatric, and adolescent anterior cruciate ligament injuries were not included in this review...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29183202/outcome-of-children-and-adolescents-with-relapsed-hodgkin-lymphoma-treated-with-high-dose-therapy-and-autologous-stem-cell-transplantation-the-memorial-sloan-kettering-cancer-center-experience
#15
Lisa Giulino-Roth, Tara O'Donohue, Zhengming Chen, Tanya M Trippett, Elizabeth Klein, Nancy A Kernan, Rachel Kobos, Susan E Prockop, Andromachi Scaradavou, Neerav Shukla, Peter G Steinherz, Alison J Moskowitz, Craig H Moskowitz, Farid Boulad
To evaluate outcomes and prognostic markers among children with relapsed Hodgkin lymphoma (HL) treated with autologous stem cell transplant (ASCT), we conducted a retrospective analysis of 36 consecutive pediatric patients treated at Memorial Sloan Kettering Cancer Center from 1989 to 2013. With a median follow-up of 9.6 years, the 10-year overall survival (OS) and event-free survival (EFS) were 74.1 and 67.1% respectively. Absence of B-symptoms, chemotherapy-sensitive disease, and transplant date after 1997 were each associated with superior EFS [HR 0...
November 29, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29179353/use-of-silver-diamine-fluoride-for-dental-caries-management-in-children-and-adolescents-including-those-with-special-health-care-needs
#16
(no author information available yet)
BACKGROUND: This manuscript presents evidence-based guidance on the use of 38 percent silver diamine fluoride (SDF) for dental caries management in children and adolescents, including those with special health care needs. A guideline workgroup formed by the American Academy of Pediatric Dentistry developed guidance and an evidence-based recommendation regarding the application of 38 percent SDF to arrest cavitated caries lesions in primary teeth. TYPES OF STUDIES REVIEWED: The basis of the guideline's recommendation is evidence from an existing systematic review "Clinical trials of silver diamine fluoride in arresting caries among children: A systematic review...
September 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29178424/does-change-in-perceptions-of-peer-teen-dating-violence-predict-change-in-teen-dating-violence-perpetration-over-time
#17
Ryan C Shorey, Brian Wymbs, Liz Torres, Joseph R Cohen, Paula J Fite, Jeff R Temple
Research has previously demonstrated that perceptions of peer's teen dating violence (TDV) is associated with one's own perpetration of TDV, although little research has examined whether this relationship is consistent across developmental time periods (i.e., mid-to-late adolescence). The present study examined whether changes in perceptions of peer's TDV predicted change in one's own perpetration of TDV in a sample of ethnically diverse adolescents from ages 15 to 18 (N = 1,042). Parallel process modeling demonstrated that decreases in perceptions of peer's TDV predicted decreases in TDV perpetration over time, and this relationship was more pronounced for males than females...
November 27, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/29172601/reciprocal-variations-in-sleep-and-drinking-over-time-among-heavy-drinking-young-adults
#18
Lisa M Fucito, Krysten W Bold, Eliza Van Reen, Nancy S Redeker, Stephanie S O'Malley, Tess H Hanrahan, Kelly S DeMartini
Prior studies have established an association between sleep problems during early adolescence and heavy alcohol use/alcohol use disorder (AUD) risk in late adolescence. Less research has explored the association between sleep problems and heavy alcohol use during young adulthood, the period when AUD onset peaks. Moreover, research to date has primarily utilized cross-sectional, between-subjects' methods to examine this relationship, with limited focus on the potential intraindividual variation in these behaviors...
November 27, 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29172011/therapy-and-rehabilitation-of-mild-brain-injury-concussion-systematic-review
#19
Roger E Thomas, Jorge Alves, Marcus M Vaska Mlis, Rosana Magalhaes
BACKGROUND: Assessment of therapies for the key consequences of mild traumatic brain injury (mTBI)/concussion is required. OBJECTIVE: Identify all RCTs of mTBI/concussion therapy, risks of bias, and therapies with significant positive results. METHODS: 17 electronic, 9 grey-literature databases searched without language/date restrictions; independent assessment of 1450 Abstracts/titles, 141 fulltext articles, 14 included RCTs. RESULTS: Four RCTs used American Congress of Rehabilitation TBI definition, others used unique definitions...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29168144/a-review-of-chronic-granulomatous-disease
#20
REVIEW
Danielle E Arnold, Jennifer R Heimall
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst in phagocytic leukocytes. Patients with CGD are at increased risk of life-threatening infections with catalase-positive bacteria and fungi and inflammatory complications such as CGD colitis. The implementation of routine antimicrobial prophylaxis and the advent of azole antifungals has considerably improved overall survival. Nevertheless, life expectancy remains decreased compared to the general population...
November 22, 2017: Advances in Therapy
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