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Mucosal leishmaniasis

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https://www.readbyqxmd.com/read/29281707/inhibitory-activity-of-pentacyano-isoniazid-ferrate-ii-iqg-607-against-promastigotes-and-amastigotes-forms-of-leishmania-braziliensis
#1
Camila F Amorim, Luiza Galina, Natália B Carvalho, Nathalia D M Sperotto, Kenia Pissinate, Pablo Machado, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior, Edgar M Carvalho, Diógenes Santiago Santos
M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M. tuberculosis, a key component in the FASII system. Here, we aimed to evaluate the inhibitory activity of IQG-607 against promastigote and amastigote forms of Leishmania (Viannia) braziliensis isolated from patients with different clinical forms of L. braziliensis infection, including cutaneous, mucosal and disseminated leishmaniasis...
2017: PloS One
https://www.readbyqxmd.com/read/29226827/cutaneous-leishmaniasis-in-senegal-a-series-of-38-cases-at-the-aristide-le-dantec-university-hospital-in-dakar
#2
S Diadie, B A Diatta, M Ndiaye, N B Seck, S Diallo, S O Niang, M T Dieng
Our aims were to study the epidemiological, clinical, and parasitological aspects of cutaneous leishmaniasis in the dermatology department of the Aristide Le Dantec hospital. This retrospective study reviewed records of cases treated over a 4-year period (from April 2010 through April 2014) at the HALD Dermatology department. The study included all patients with cutaneous leishmaniasis during the study period. The diagnostic criteria were clinical, parasitological, and histological. The study included 38 patients, corresponding to 9...
December 11, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29211245/low-dose-systemic-or-intralesional-meglumine-antimoniate-treatment-for-american-tegumentary-leishmaniasis-results-in-low-lethality-low-incidence-of-relapse-and-low-late-mucosal-involvement-in-a-referral-centre-in-rio-de-janeiro-brazil-2001-2013
#3
Lucia Regina Brahim, Cláudia Maria Valete-Rosalino, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Luiz Eduardo de Carvalho Paes, Ananda Dutra da Costa, Iracema Forni Vieira, Cristina Maria Giordano Dias, Maria Cristina de Oliveira Duque, Mauro Celio de Almeida Marzochi, Armando de Oliveira Schubach
BACKGROUND: American tegumentary leishmaniasis (ATL) is a non-lethal parasitic disease that presents with cutaneous (CL) and mucosal (ML) clinical forms. ATL treatment aims at healing the lesions and preventing the development of the late mucosal form. Systemic meglumine antimoniate (MA) therapy with 10-20 mg Sb5+/kg/day is the first choice of treatment. However, alternative therapies using 5 mg Sb5+/kg/day or intralesional (IL) MA are the usual regimens at the National Institute of Infectious Diseases (NIID), Rio de Janeiro, Brazil...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29197952/first-identification-of-l-major-in-a-dog-in-an-endemic-area-of-human-cutaneous-leishmaniasis-in-iraq-molecular-and-phylogenetic-studies
#4
Mariwan M M Al-Bajalan, Sherko S Niranji, Sirwan M A Al-Jaf, Hirotomo Kato
Canine leishmaniasis (CanL) caused by Leishmania infantum (L. infantum) is considered as a zoonotic disease and within the last few decades, studies have identified the parasite as a major causative agent of human visceral leishmaniasis. However, in dogs, few recent studies have determined L. major as a cause of cutaneous manifestations and L. tropica as an etiological agent for cutaneous lesions involving mucosa. Interestingly, current study has found canine cutaneous lesions with mucosal involvement in a dog diagnosed with L...
December 3, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29187956/-leg-ulcer-revealing-cutaneous-leishmaniasis
#5
Elalouani Elmehdi, Bachar Zerkly
Leishmaniases are parasitic diseases occurring in endemic tropical and subtropical areas and caused by protozoa of the genus leishmania, transmitted by a diptera (sand fly). We here report a case of topical cutaneous leishmaniasis discovered in a 15-year old boy with painless ulcer on his left leg, who had been staying in South Africa. Clinical examination showed painless non-itchy ulcer, occurred 1 month before, on the antero-internal part of his left leg with crusts and scars caused by insect bites, all evolving in a context of patient's general health status, without mucosal or visceral lesions...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29167671/immune-checkpoint-targets-for-host-directed-therapy-to-prevent-and-treat-leishmaniasis
#6
REVIEW
Rajiv Kumar, Shashi Bhushan Chauhan, Susanna S Ng, Shyam Sundar, Christian R Engwerda
Leishmaniasis encompasses a group of diseases caused by protozoan parasites belonging to the genus Leishmania. These diseases range from life threatening visceral forms to self-healing cutaneous lesions, and each disease manifestations can progress to complications involving dissemination of parasites to skin or mucosal tissue. A feature of leishmaniasis is the key role host immune responses play in disease outcome. T cells are critical for controlling parasite growth. However, they can also contribute to disease onset and progression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#7
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29095818/dynamics-of-american-tegumentary-leishmaniasis-in-a-highly-endemic-region-for-leishmania-viannia-braziliensis-infection-in-northeast-brazil
#8
Juliana Silva, Adriano Queiroz, Izabella Moura, Rosana S Sousa, Luiz Henrique Guimarães, Paulo Roberto Lima Machado, Marcus Lessa, Ednaldo Lago, Mary E Wilson, Albert Schriefer
BACKGROUND: American Tegumentary Leishmaniasis (ATL) caused by Leishmania braziliensis is endemic in Corte de Pedra, Northeast Brazil. Most L. braziliensis infections manifest as localized cutaneous leishmaniasis (CL). Disseminated manifestations include mucosal leishmaniasis (ML), present at a low constant level for several decades, and newly emerging disseminated leishmaniasis (DL). Surprisingly, DL has recently surpassed ML in its spatial distribution. This led us to hypothesize that distinct forms of ATL might spread in different patterns through affected regions...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29042262/molecular-epidemiology-and-in-vitro-evidence-suggest-that-leishmania-braziliensis-strain-helps-determine-antimony-response-among-american-tegumenary-leishmaniasis-patients
#9
Silvana C Silva, Luiz Henrique Guimarães, Juliana A Silva, Viviane Magalhães, Lilian Medina, Adriano Queiroz, Paulo Roberto L Machado, Albert Schriefer
Antimony is the first line drug for treating American tegumentary leishmaniasis (ATL) in Brazil. In this country, Leishmania braziliensis causes at least three distinct forms of disease: localized cutaneous (CL), mucosal (ML) and disseminated leishmaniasis (DL). All forms can be found in Corte de Pedra, Northeast Brazil. ML and DL respond poorly to antimony, in contrast to CL. The L. braziliensis population causing ATL in Corte de Pedra is genetically very diverse, with strains of the parasite associating with the clinical form of leishmaniasis...
October 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29031288/case-report-old-world-mucosal-leishmaniasis-report-of-five-imported-cases-to-the-hospital-for-tropical-diseases-london-united-kingdom
#10
Trupti A Patel, Glenis K Scadding, David E Phillips, Diana N Lockwood
Old World species of Leishmania typically cause visceral and cutaneous leishmaniasis. Mucosal involvement is typically seen with infection by Leishmania species found in South America, usually after the healing of cutaneous leishmaniasis. We present five imported cases of mucosal leishmaniasis caused by Old World Mediterranean Leishmania infantum exclusively affecting the nasal mucosa or vocal cord. In only one case was there a recollection of a preceding cutaneous lesion compatible with cutaneous Leishmaniasis...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29016694/efficacy-of-azole-therapy-for-tegumentary-leishmaniasis-a-systematic-review-and-meta-analysis
#11
REVIEW
Endi Lanza Galvão, Ana Rabello, Gláucia Fernandes Cota
BACKGROUND: Several controlled and uncontrolled studies addressing azole antifungal drugs for cutaneous and mucosal leishmaniasis have been published with inconclusive results. We conducted a systematic literature review of studies evaluating the efficacy and toxicity associated with azole therapy for tegumentary leishmaniasis. METHODOLOGY: PRISMA guidelines for systematic reviews and the Cochrane manual were followed, and the review methodology was registered (PROSPERO; CRD42016048668)...
2017: PloS One
https://www.readbyqxmd.com/read/28981507/reappraisal-of-leishmanin-skin-test-lst-in-the-management-of-american-cutaneous-leishmaniasis-a-retrospective-analysis-from-a-reference-center-in-argentina
#12
Alejandro Javier Krolewiecki, Maria Cristina Almazan, Marcelo Quipildor, Marisa Juarez, Jose Fernando Gil, Marco Espinosa, Maria Canabire, Silvana Pamela Cajal
Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leishmania antigens injected intradermally, used in endemic areas as a complement to diagnosis. A retrospective analysis of individuals evaluated for their first episode of tegumentary leishmaniasis at a reference center in Argentina during the period 2006-2015 was performed, with the goal of assessing its usefulness as a support tool in the diagnosis of leishmaniasis...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28968786/influence-of-leishmania-rna-virus-1-on-proinflammatory-biomarker-expression-in-a-human-macrophage-model-of-american-tegumentary-leishmaniasis
#13
Ruwandi Kariyawasam, Jugvinder Grewal, Rachel Lau, Andrew Purssell, Braulio M Valencia, Alejandro Llanos-Cuentas, Andrea K Boggild
Backgound: Species of the Leishmania Viannia (L. V.) subgenus harbor the double-stranded Leishmania RNA virus 1 (LRV-1), previously identified in isolates from Brazil and Peru. Higher levels of LRV-1 in metastasizing strains of L. V. guyanensis have been documented in both human and murine models, and correlated to disease severity. Methods: Expression of proinflammatory biomarkers, including interleukin (IL) 1β, tumor necrosis factor alpha (TNF-α), CXCL10, CCL5, IL-6, and superoxide dismutase, in human macrophages infected with 3 ATCC and 5 clinical isolates of L...
October 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934199/mucosal-leishmaniasis-mimicking-t-cell-lymphoma-in-a-patient-receiving-monoclonal-antibody-against-tnf%C3%AE
#14
Antonio Carlos Nicodemo, Daniel Fernandes Duailibi, Diego Feriani, Maria Irma Seixas Duarte, Valdir Sabbaga Amato
No abstract text is available yet for this article.
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28926630/efficacy-of-pentavalent-antimoniate-intralesional-infiltration-therapy-for-cutaneous-leishmaniasis-a-systematic-review
#15
REVIEW
Nayara Castelano Brito, Ana Rabello, Gláucia Fernandes Cota
BACKGROUND: The mainstays of cutaneous leishmaniasis (CL) treatment, in several world regions, are pentavalent antimony (Sbv) compounds administered parenterally, despite their recognized toxicity, which requires frequent laboratory monitoring and complicates their use in areas with scarce infrastructure. As result of these drawbacks, the WHO Expert Committee on leishmaniasis has expanded the recommendations for the use of local therapies, including Sbv intralesional infiltration (IL-Sbv), as CL therapy alternatives even in the New World...
2017: PloS One
https://www.readbyqxmd.com/read/28776770/cutaneous-leishmaniasis-by-leishmania-infantum-behind-granulomatous-lesions-of-unknown-aetiology
#16
G Merino-Espinosa, V Corpas-López, V Díaz-Sáez, F Morillas-Márquez, J Tercedor-Sánchez, J M Azaña-Defez, J López-Hidalgo, J Aneiros-Fernández, J Martín-Sánchez
BACKGROUND: Cutaneous leishmaniasis (CL) is underestimated in Spain as in other European countries due to the polymorphism of its clinical manifestations and histopathological features discouraging doctors from suspecting leishmaniasis. Mucosal manifestations (ML) are misdiagnosed due to the fact that they often mimic cancer. OBJECTIVES: Given that leishmaniasis may be masked as different granulomatous diseases in Leishmania infantum endemic areas, the aim of this study was to verify this misdiagnosing and contributes to the improvement of CL/ML diagnosis...
August 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28722607/mucosal-leishmaniasis-a-retrospective-study-of-327-cases-from-an-endemic-area-of-leishmania-viannia-braziliensis
#17
Carolina Cincurá, Clara Mônica F de Lima, Paulo R L Machado, Jamary Oliveira-Filho, Marshall J Glesby, Marcus M Lessa, Edgar M Carvalho
Mucosal leishmaniasis (ML) is observed only in about 3% of patients with American tegumentary leishmaniasis (ATL) but has a high potential for destructive, disfiguring, and disabling sequelae. Prior reports of clinical and epidemiologic features of ML are limited by small numbers of cases. In this study, we evaluated changes in the demographic features and clinical presentation of ML in an endemic area of Leishmania braziliensis transmission over a period of 20 years. The charts of 327 patients with ML diagnosed between 1995 and 2014 were reviewed...
September 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28704369/clinical-and-parasitological-factors-in-parasite-persistence-after-treatment-and-clinical-cure-of-cutaneous-leishmaniasis
#18
Alvaro J Martínez-Valencia, Carlos Frisherald Daza-Rivera, Mariana Rosales-Chilama, Alexandra Cossio, Elkin J Casadiego Rincón, Mayur M Desai, Nancy Gore Saravia, María Adelaida Gómez
BACKGROUND: The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by L. Viannia. METHODS: Seventy patients who were treated with meglumine antimoniate (n = 38) or miltefosine (n = 32) and cured, were included in this study...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28687071/recurrence-of-visceral-and-muco-cutaneous-leishmaniasis-in-a-patient-under-immunosuppressive-therapy
#19
Gilles Darcis, Gert Van der Auwera, Jean-Baptiste Giot, Marie-Pierre Hayette, Françoise Tassin, Jorge Arrese Estrada, Lieselotte Cnops, Michel Moutschen, Laurence de Leval, Philippe Leonard
BACKGROUND: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or malignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively. CASE PRESENTATION: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis...
July 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28686398/-leishmaniasis-an-infection-of-travellers-and-migrants
#20
Lena Jessen, Benoît Bard, Xavier Grenon, Frank Bally
Leishmaniasis is an infection of the tropical to temperate zone, occasionally imported in our regions by travellers and migrants. Leishmania parasites are transmitted by the sting of a sand fly, Phlebotomus or Lutzomyia, and causes two clinical syndromes with either cutaneous, also mucosal, or disseminated involvement. Clinical suspicion needs a confirmation by the detection of the parasite. The treatment is adapted to the patient, the clinical presentation, the region, the species and the availability. Cutaneous leishmaniasis can be observed only or treated by topical or systemic regimens...
October 12, 2016: Revue Médicale Suisse
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