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Mucosal leishmaniasis

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https://www.readbyqxmd.com/read/28076469/scoring-clinical-signs-can-help-diagnose-canine-visceral-leishmaniasis-in-a-highly-endemic-area-in-brazil
#1
Kleverton Ribeiro da Silva, Vitor Rosa Ramos de Mendonça, Kellen Matuzzy Silva, Leopoldo Fabrício Marçal do Nascimento, Antonio Ferreira Mendes-Sousa, Flaviane Alves de Pinho, Manoel Barral-Netto, Aldina Maria Prado Barral, Maria do Socorro Pires E Cruz
Canine visceral leishmaniasis (CVL) diagnosis is still a challenge in endemic areas with limited diagnostic resources. This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28076468/phenotypic-diversity-and-selection-maintain-leishmania-amazonensis-infectivity-in-balb-c-mouse-model
#2
Benoît Espiau, Virginia Vilhena, Armelle Cuvillier, Aldina Barral, Gilles Merlin
Leishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions. The exact nature and extent of Leishmania phenotypic diversity in establishing infection is not fully understood. In order to try to understand some aspects of this diversity, we subcutaneously infected BALB/c mice with first and second generation subclones of a L. amazonensis strain isolated from a patient (BA125) and examined in vivo lesion growth rate and antimony susceptibility...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27927916/field-validation-of-sybr%C3%A2-green-and-taqman%C3%A2-based-real-time-pcr-using-biopsy-and-swab-samples-to-diagnose-american-tegumentary-leishmaniasis-in-a-leishmania-v-braziliensis-endemic-area
#3
Ciro Martins Gomes, Mariana Vicente Cesetti, Natália Aparecida de Paula, Sebastián Vernal, Gaurav Gupta, Raimunda Nonata Ribeiro Sampaio, Ana Maria Roselino
The precise diagnosis of American tegumentary leishmaniasis (ATL) is an essential task due to the disease's associated morbidity. A non-invasive, extremely sensitive and highly specific exam is critical, particularly for mucosal leishmaniasis (ML), in which a low parasite quantity is expected. We aimed to compare the diagnostic accuracy of swab and biopsy sample analysis using SYBR® Green- and TaqMan®-based real-time polymerase chain reaction (qPCR) assays with that of a composite reference standard consisting of the Montenegro skin test, serology, histopathology, smears, culture and conventional PCR...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27832423/cutaneous-and-visceral-leishmaniasis-during-anti-tnf%C3%AE-therapy
#4
Claudio Guarneri, Valentina Bevelacqua, James W Patterson, Georgi Tchernev
The long-term use of novel antipsoriatic systemic biotechnological drugs may increase susceptibility to opportunistic infections. Several cases of visceral leishmaniasis have been reported in immunosuppressed individuals, including those who have been treated with tumour necrosis factor alpha (TNFα) blocking agents. Simultaneous occurrence of cutaneous and visceral involvement has been more rarely recorded in the medical literature. Herein, we describe a case of mucosal leishmaniasis occurring in a farmer living in an endemic region, who was treated with golimumab because of psoriatic arthritis...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27812654/clinical-laboratory-and-therapeutic-characteristics-of-american-tegumentary-leishmaniasis-in-the-15-th-state-health-division-northwest-paran%C3%A3-state-southern-brazil
#5
Priscila Wolf Nassif, Marcela Castilho-Peres, Ana Paula Zanatta Rosa, Aline Laureano da Silva, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira
INTRODUCTION: American tegumentary leishmaniasis (ATL) is an endemic disease in many regions of Brazil; however, only few reports on the actual epidemiological conditions are available. Here, we aimed to assess the clinical, epidemiological, and laboratory characteristics of ATL patients and their treatment in the 15th Regional Health Division of Paraná State, Maringá, Brazil. METHODS: This epidemiological study included patients diagnosed with ATL from January 2010 to September 2014, from the 15th Regional Health Division database...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27716449/efficacy-of-intranasal-laag-vaccine-against-leishmania-amazonensis-infection-in-partially-resistant-c57bl-6-mice
#6
Juliana Elena Silveira Pratti, Tadeu Diniz Ramos, Joyce Carvalho Pereira, Alessandra Marcia da Fonseca-Martins, Diogo Maciel-Oliveira, Gabriel Oliveira-Silva, Mirian França de Mello, Suzana Passos Chaves, Daniel Claudio Oliveira Gomes, Bruno Lourenço Diaz, Bartira Rossi-Bergmann, Herbert Leonel de Matos Guedes
BACKGROUND: We have previously demonstrated that intranasal vaccination of highly susceptible BALB/c mice with whole Leishmania amazonensis antigens (LaAg) leads to protection against murine cutaneous leishmaniasis. Here, we evaluate the response of partially resistant C57BL/6 mice to vaccination as a more representative experimental model of human cutaneous leishmaniasis. METHODS: C57BL/6 mice from different animal facilities were infected with L. amazonensis (Josefa strain) to establish the profile of infection...
October 6, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27515498/localized-mucosal-leishmaniasis-caused-by-leishmania-infantum-mimicking-cancer-in-the-rhinolaryngeal-region
#7
Fernando Cobo, Javier Rodríguez-Granger, Cristina Gómez-Camarasa, Antonio Sampedro, Luis Aliaga-Martínez, José María Navarro, José Gutiérrez Fernández
The clinical, microbiological, and histopathological findings of six patients with mucosal leishmaniasis are reported. Five of these patients were Spanish with no history of travel abroad, while the other was from Bolivia but had lived in Spain for more than 5 years. Two patients had no underlying disease, while the other four had several other medical conditions. Lesions were located in the nose in three patients and in the larynx in the other three. Symptoms included difficulty in swallowing, nasal obstruction, dysphonia, and polypoid lesions mimicking cancer...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27475453/pharmacokinetics-and-bioavailability-assessment-of-miltefosine-in-rats-using-high-performance-liquid-chromatography-tandem-mass-spectrometry
#8
Guru R Valicherla, Priyanka Tripathi, Sandeep K Singh, Anees A Syed, Mohammed Riyazuddin, Athar Husain, Deep Javia, Kishan S Italiya, Prabhat R Mishra, Jiaur R Gayen
Miltefosine (MFS) is the first effective oral drug for treatment of visceral, mucosal and cutaneous leishmaniasis. In this study, liquid chromatography coupled mass spectrometry (LC-MS/MS) method of MFS was validated in rat plasma and its practical utilization to pharmacokinetic studies in rats for the first time. A rapid, selective and sensitive LC-MS/MS method for MFS in rat plasma was linear over the calibration range of 1-500ng/mL. MFS and Phenacetin (internal standard) were separated on Phenomenex Luna 3μ HILIC 200A (150×4...
September 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27438595/drug-search-for-leishmaniasis-a-virtual-screening-approach-by-grid-computing
#9
Rodrigo Ochoa, Stanley J Watowich, Andrés Flórez, Carol V Mesa, Sara M Robledo, Carlos Muskus
The trypanosomatid protozoa Leishmania is endemic in ~100 countries, with infections causing ~2 million new cases of leishmaniasis annually. Disease symptoms can include severe skin and mucosal ulcers, fever, anemia, splenomegaly, and death. Unfortunately, therapeutics approved to treat leishmaniasis are associated with potentially severe side effects, including death. Furthermore, drug-resistant Leishmania parasites have developed in most endemic countries. To address an urgent need for new, safe and inexpensive anti-leishmanial drugs, we utilized the IBM World Community Grid to complete computer-based drug discovery screens (Drug Search for Leishmaniasis) using unique leishmanial proteins and a database of 600,000 drug-like small molecules...
July 2016: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/27415630/pediatric-cutaneous-leishmaniasis-in-an-endemic-region-in-turkey-a-retrospective-analysis-of-8786-cases-during-1998-2014
#10
Mustafa Aksoy, Nebiye Doni, Hatice Uce Ozkul, Yavuz Yesilova, Nurittin Ardic, Abdullah Yesilova, Jennifer Ahn-Jarvis, Steve Oghumu, Cesar Terrazas, Abhay R Satoskar
BACKGROUND: Cutaneous leishmaniasis (CL) is a major public health concern in Turkey and Sanliurfa represents the most endemic city in Turkey. Although children are most commonly affected by CL, detailed studies of pediatric CL in Turkey are lacking. METHODOLOGY/PRINCIPAL FINDINGS: In this report we retrospectively evaluated clinical and epidemiological data of 8786 pediatric CL cases, and how children respond to antimonial therapy. CL was observed most frequently in children between 6-10 years old...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27398061/diffuse-and-disseminated-cutaneous-leishmaniasis-clinical-cases-experienced-in-ecuador-and-a-brief-review
#11
Yoshihisa Hashiguchi, Eduardo L Gomez, Hirotomo Kato, Luiggi R Martini, Lenin N Velez, Hiroshi Uezato
BACKGROUND: In Ecuador, cutaneous leishmaniasis (CL) is prevalent countrywide, but only one case of diffuse-CL and two cases of disseminated-CL were experienced during our research activities more than 30 years from 1982 to date. These three patients suffered from multiple lesions distributed at a wide range of the body surface, revealing difficulty to clinically differentiate each other. METHODS: There is a considerable confusion of the use and/or differentiation of the terminologies (terms) between the two disease forms, diffuse-CL and disseminated-CL...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27350537/development-of-real-time-pcr-assays-for-evaluation-of-immune-response-and-parasite-load-in-golden-hamster-mesocricetus-auratus-infected-by-leishmania-viannia-braziliensis
#12
Raquel Peralva Ribeiro-Romão, Andrea Franco Saavedra, Alda Maria Da-Cruz, Eduardo Fonseca Pinto, Otacilio C Moreira
BACKGROUND: Cutaneous leishmaniasis (CL) is a neglected disease with a broad spectrum of clinical manifestations, ranging from small cutaneous nodules to severe mucosal tissue destruction. Leishmania (Viannia) braziliensis is the main species attributed to CL in the Americas. However, studies of experimental infection are limited in the murine model due to the self-resolutive pattern of the disease. Previously, our group demonstrated that the hamster model reproduces many of the clinical and histopathological features observed in humans...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27260217/exclusive-primary-lesion-of-oral-leishmaniasis-with-immunohistochemical-diagnosis
#13
Tatiana Fernandes Araujo Almeida, Esmeralda Maria da Silveira, Cássio Roberto Rocha Dos Santos, Jorge Esquiche León, Ana Terezinha Marques Mesquita
A case of oral leishmaniasis without cutaneous involvement affecting the upper alveolar ridge mucosa/gingiva and the hard palate is reported in a 41-year-old Brazilian man. Microscopic examination disclosed scarce amastigotes and the definitive diagnosis was facilitated by immunohistochemical analysis. The clinical presentation of this lesion is unusual and underlies the importance of considering leishmaniasis in the differential diagnosis of oral lesions, especially in endemic areas. A literature review of the cases of mucosal leishmaniasis with exclusive primary lesions of the oral mucosa was also performed...
December 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27234853/mucosal-leishmaniasis-in-brazilian-patients-two-case-reports-with-similar-clinical-presentation-and-different-approaches
#14
Aline Fernanda Cruz, Renata Gonçalves Resende, Daniel Ricaldoni Albuquerque, Júlio César Tanos de Lacerda, Camila Ferreira Leite, Maria Cássia Ferreira Aguiar
Mucosal leishmaniasis is a chronic infection that affects the upper respiratory tract and/or the oral mucosa caused by Leishmania protozoan parasites. We present two cases of oral leishmaniasis and discuss the different diagnostic strategies and treatment. In both cases, the patients were male, 60 and 94 years of age, and presented with lesions on the soft palate. In the first patient, the final diagnosis was made on the basis of histopathologic examination. In the second case, polymerase chain reaction and Montenegro skin test were necessary to confirm the diagnosis...
March 10, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27181585/in%C3%A2-vitro-characterization-of-leishmania-viannia-braziliensis-isolates-from-patients-with-different-responses-to-glucantime-%C3%A2-treatment-from-northwest-paran%C3%A3-brazil
#15
Andrea Claudia Bekner Silva Fernandes, Raíssa Bocchi Pedroso, Tatiane França Perles de Mello, Lucélia Donatti, Eneide Aparecida Sabaini Venazzi, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Thaís Gomes Verzignassi Silveira
Leishmaniasis is a group of diseases that presents various clinical manifestations. Many studies have shown that the parasite plays an important role in the clinical manifestations and prognosis of this disease. The cutaneous and mucosal forms of American tegumentary leishmaniasis (ATL) are associated with Leishmania (Viannia) braziliensis, which exhibits intraspecific genetic polymorphisms and various clinical manifestations. The present study focused on four different L. braziliensis strains that were isolated from patients with distinct Glucantime(®) treatment responses...
August 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27177688/seroepidemiology-and-molecular-diversity-of-leishmania-donovani-complex-in-georgia
#16
Giorgi Babuadze, Jason Farlow, Harry P de Koning, Eugenia Carrillo, Giorgi Chakhunashvili, Mari Murskvaladze, Merab Kekelidze, Irakli Karseladze, Nora Kokaia, Irine Kalandadze, David Tsereteli, Ivane Markhvashvili, Ketevan Sidamonidze, Gvantsa Chanturia, Ekaterine Adeishvili, Paata Imnadze
BACKGROUND: Leishmaniasis includes multiple clinical syndromes, most notably visceral, cutaneous, and mucosal forms. Visceral leishmaniasis (VL), also known as kala-azar, is a potentially fatal disease endemic to large parts of Africa and Asia, and in South-Eastern Europe (Greece, Turkey, Georgia). Visceral leishmaniasis is a parasitic zoonosis caused by species of the L. donovani complex. In the classical epidemiological model the main reservoir for VL are canines. METHODS: The study included a cohort of 513 individuals of both genders (190 males and 323 females) from the ages of 1 to 70 years that were screened in ten villages across two districts in Kakheti using the Kalazar Detect™ rK39 rapid diagnostic test...
13, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27115155/an-innovative-field-applicable-molecular-test-to-diagnose-cutaneous-leishmania-viannia-spp-infections
#17
Omar A Saldarriaga, Alejandro Castellanos-Gonzalez, Renato Porrozzi, Gerald C Baldeviano, Andrés G Lescano, Maxy B de Los Santos, Olga L Fernandez, Nancy G Saravia, Erika Costa, Peter C Melby, Bruno L Travi
Cutaneous and mucosal leishmaniasis is widely distributed in Central and South America. Leishmania of the Viannia subgenus are the most frequent species infecting humans. L. (V.) braziliensis, L. (V.) panamensis are also responsible for metastatic mucosal leishmaniasis. Conventional or real time PCR is a more sensitive diagnostic test than microscopy, but the cost and requirement for infrastructure and trained personnel makes it impractical in most endemic regions. Primary health systems need a sensitive and specific point of care (POC) diagnostic tool...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27090730/new-serological-tools-for-improved-diagnosis-of-human-tegumentary-leishmaniasis
#18
Lourena E Costa, Beatriz C S Salles, Patrícia T Alves, Ana C S Dias, Emília R Vaz, Fernanda F Ramos, Daniel Menezes-Souza, Mariana C Duarte, Bruno M Roatt, Miguel A Chávez-Fumagalli, Carlos A P Tavares, Denise U Gonçalves, Manoel O C Rocha, Luiz Ricardo Goulart, Eduardo A F Coelho
Human tegumentary leishmaniasis (HTL), characterized by skin ulcers that may spread and cause dreadful and massive tissue destruction of the nose and mouth, is considered a neglected tropical disease, and it is a serious threat to global health due to its continuous expansion, favored by the lifecycle of its causative organism that is maintained in domestic animal reservoirs and anthropophilic sand fly species. Serodiagnosis of HTL is a great challenge due to many biological factors, including hampered specificity and/or sensitivity...
July 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27073255/leishmania-viannia-braziliensis-amastigotes-from-patients-with-mucosal-leishmaniasis-have-increased-ability-to-disseminate-and-are-controlled-by-nitric-oxide-at-the-early-stage-of-murine-infection
#19
Clayson M Gomes, Lucilla R Ávila, Jéssica C Santos, Pollyana G Oliveira, Fernanda D Tomé, Ledice I A Pereira, Miriam L Dorta, Ruy S Lino, Fátima Ribeiro-Dias, Milton A P Oliveira
Mucosal leishmaniasis (ML) caused by Leishmania (Vianna) braziliensis usually appears after the healing of the primary lesion when amastigotes disseminate from the infection site to the mucosal area. Here, we investigated murine infection with amastigotes obtained from patients with ML or localized cutaneous leishmaniasis (LCL). Amastigotes were used to infect wild type, IFN-γ KO and inducible nitric oxide synthase (iNOS) KO mice. Amastigotes from patients with LCL induced lesions that appeared earlier in IFN-γ KO than parasites from ML...
June 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27042675/miltefosine-for-mucosal-and-complicated-cutaneous-old-world-leishmaniasis-a-case-series-and-review-of-the-literature
#20
Vincent Mosimann, Claudia Blazek, Heini Grob, Matthew Chaney, Andreas Neumayr, Johannes Blum
Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.
January 2016: Open Forum Infectious Diseases
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