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https://www.readbyqxmd.com/read/29777479/frontal-delta-beta-cross-frequency-coupling-in-high-and-low-social-anxiety-an-index-of-stress-regulation
#1
Eefje S Poppelaars, Anita Harrewijn, P Michiel Westenberg, Melle J W van der Molen
Cross-frequency coupling (CFC) between frontal delta (1-4 Hz) and beta (14-30 Hz) oscillations has been suggested as a candidate neural correlate of social anxiety disorder, a disorder characterized by fear and avoidance of social and performance situations. Prior studies have used amplitude-amplitude correlation (AAC) as a CFC measure and hypothesized it as a candidate neural mechanism of affective control. However, using this metric has yielded inconsistent results regarding the direction of CFC, and the functional significance of coupling strength is uncertain...
May 17, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29777316/characterization-of-the-complete-sequences-and-stability-of-plasmids-carrying-the-genes-aac-6-ib-cr-or-qnrs-in-shigella-flexneri-in-the-hangzhou-area-of-china
#2
Xiao-Ying Pu, Yaming Gu, Jun Li, Shu-Juan Song, Zhe Lu
The aim of this study was to explore the fluoroquinolone resistance mechanism of aac (6')-Ib-cr and qnrS gene by comparing complete sequences and stability of the aac(6')-Ib-cr- and qnrS-positive plasmids from Shigella isolates in the Hangzhou area of China. The complete sequences of four newly acquired plasmids carrying aac(6')-Ib-cr or qnrS were compared with those of two plasmids obtained previously and two similar reference Escherichia coli plasmids. The results showed that the length, antibiotic resistance genes and genetic environment were different among the plasmids...
May 18, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29776559/angioedema-in-heart-failure-patients-treated-with-sacubitril-valsartan-lcz696-or-enalapril-in-the-paradigm-hf-study
#3
Victor Shi, Michele Senni, Hendrik Streefkerk, Vikas Modgill, Wenchun Zhou, Allen Kaplan
BACKGROUND: PARADIGM-HF demonstrated significant clinical benefits for sacubitril/valsartan (LCZ696, an angiotensin receptor neprilysin inhibitor) versus the angiotensin-converting enzyme inhibitor (ACEI) enalapril in patients with heart failure with reduced ejection fraction. As inhibition of ACE, and co-inhibition of ACE and neprilysin, may increase the risk of angioedema, this was an adverse event of special interest. METHODS: Following sequential enalapril and sacubitril/valsartan run-ins, patients were randomized to twice-daily sacubitril/valsartan 200 mg or enalapril 10 mg...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29775762/aortic-vascular-calcification-is-inversely-associated-with-the-trabecular-bone-score-in-patients-receiving-dialysis
#4
Jasna Aleksova, Samantha Kurniawan, Mirna Vucak-Dzumhur, Peter Kerr, Peter R Ebeling, Frances Milat, Grahame J Elder
INTRODUCTION: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume, reduce the ability of DXA to predict fracture...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29775634/the-direction-of-protein-evolution-is-destined-by-the-stability
#5
Natsuko Ota, Ryo Kurahashi, Satoshi Sano, Kazufumi Takano
Protein evolution is potentially governed by protein stability. Here, we investigated the relationship between protein evolution and stability through the random mutational drift of a thermophilic bacterial protein, an esterase of Alicyclobacillus acidocaldarius (Aac-Est), at high and low temperatures. In the first random mutation of Aac-Est, few proteins exhibit increased activity at 65°C, indicating that the wild-type (WT) Aac-Est is located on the peak of a mountain in a fitness landscape for activity at high temperature...
May 15, 2018: Biochimie
https://www.readbyqxmd.com/read/29773397/self-healable-tough-supramolecular-hydrogels-crosslinked-by-poly-cyclodextrin-through-host-guest-interaction
#6
Tingting Cai, Shuangjun Huo, Tao Wang, Weixiang Sun, Zhen Tong
A new supramolecular hydrogel with superior self-healing and shape memory properties was synthesized via in-situ copolymerization of the adamantane-containing monomer N-adamantylacrylamide (Ad-AAm) and monomer acrylic acid (AAc) in the polycyclodextrin (PCD) aqueous solution, where PCD served as the polyfunctional physical cross-linker. The PCD-Ad hydrogels showed strength of 40 kPa with breaking strain of 600%, but small tensile loading-unloading hysteresis and residual deformation benefited from the reversible crosslinking structure...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773380/chitosan-derivative-based-self-healable-hydrogels-with-enhanced-mechanical-properties-by-high-density-dynamic-ionic-interactions
#7
Ningxiao Yuan, Lu Xu, Bo Xu, Jianhao Zhao, Jianhua Rong
Chitosan derivative-based self-healable hydrogels with enhanced mechanical properties are reported, which were prepared by polymerization of acrylic acid (AAc) in 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) solution. The PAAc/HACC hydrogels exhibit tensile fracture stress as high as 3.31 MPa and a Young's modulus of 2.53 MPa. They can maintain their original shape after 30 repeated compression cycles under various strain conditions, with a compression stress of more than 60 MPa at 99% strain...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772935/the-effects-of-literacy-interventions-on-single-word-reading-for-individuals-who-use-aided-aac-a-systematic-review
#8
Kelsey Mandak, Janice Light, Susannah Boyle
The purpose of this systematic review was to investigate the effects of instruction on single-word reading of individuals who use aided augmentative and alternative communication (AAC). A systematic search identified nine single-case experimental design studies that involved 24 individuals who used aided AAC. Overall, the evidence indicated that instruction had positive effects on reading at the single-word level for individuals across ages and diagnostic categories (i.e., autism spectrum disorder (ASD), cerebral palsy (CP), Down syndrome, and intellectual disability)...
May 18, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29772394/antimicrobial-resistance-and-genetic-lineages-of-faecal-enterococci-of-wild-birds-emergence-of-vana-and-vanb2-harboring-enterococcus-faecalis
#9
Houssem Ben Yahia, Sarra Chairat, Nabil Hamdi, Haythem Gharsa, Rym Ben Sallem, Sara Ceballos, Carmen Torres, Karim Ben Slama
Migrating birds have been implicated in pathogen dissemination over long-distances. The lack of data on birds' intestinal microbiota makes these animals a promising path to understand their potential role in the transmission of antibiotic resistant bacteria. This work aims to study the diversity of enterococci species and to analyze the antimicrobial resistant phenotypes/genotypes, as well as the genetic lineages of isolates obtained from faecal and pellet samples of colonial wild birds in Tunisia. Seventy-nine enterococci were recovered of 150 wild bird, after inoculation of samples in Slanetz-Bartley agar, and were identified as E...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29762509/breathing-pattern-interpretation-as-an-alternative-and-effective-voice-communication-solution
#10
Yasmin Elsahar, Kaddour Bouazza-Marouf, David Kerr, Atul Gaur, Vipul Kaushik, Sijung Hu
Augmentative and alternative communication (AAC) systems tend to rely on the interpretation of purposeful gestures for interaction. Existing AAC methods could be cumbersome and limit the solutions in terms of versatility. The study aims to interpret breathing patterns (BPs) to converse with the outside world by means of a unidirectional microphone and researches breathing-pattern interpretation (BPI) to encode messages in an interactive manner with minimal training. We present BP processing work with (1) output synthesized machine-spoken words (SMSW) along with single-channel Weiner filtering (WF) for signal de-noising, and (2) k -nearest neighbor ( k-NN ) classification of BPs associated with embedded dynamic time warping (DTW)...
May 15, 2018: Biosensors
https://www.readbyqxmd.com/read/29760137/identification-and-characterization-of-conjugative-plasmids-that-encode-ciprofloxacin-resistance-in-salmonella
#11
Kaichao Chen, Ning Dong, Shaohua Zhao, Lizhang Liu, Ruichao Li, Miaomiao Xie, Dachuan Lin, Edward Wai-Chi Chan, Jianghong Meng, Patrick F McDermott, Sheng Chen
This study aimed to characterize novel conjugative plasmids that encode transferrable ciprofloxacin resistance in Salmonella In this study, 157 non-duplicated Salmonella isolates were recovered from food products, 55 out of which were found to be resistant to ciprofloxacin. Interestingly, 37 out of the 55 (67%) CipR Salmonella isolates did not harbor any mutations in the Quinolone resistance determine regions (QRDR). Interestingly, six Salmonella isolates were shown to carry two novel types of conjugative plasmids that could transfer ciprofloxacin resistance phenotype to E...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29750417/hits-clip-reveals-sex-differential-rna-binding-and-alterative-splicing-regulation-of-srm160-in-drosophila
#12
Chen Qiu, Yu Zhang, Yu-Jie Fan, Ting-Lin Pang, Yan Su, Shuai Zhan, Yong-Zhen Xu
Serine/arginine (SR)-rich proteins are critical for the regulation of alternative splicing (AS), which generates multiple mRNA isoforms from one gene and provides protein diversity for cell differentiation and tissue development. Genetic evidence suggests that Drosophila genital-specific overexpression of SR-related nuclear matrix protein of 160 kDa (SRm160), an SR protein with a PWI RNA-binding motif, causes defective development only in male flies and results in abnormal male genital structures and abnormal testis...
May 10, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29748922/defining-the-relationship-between-phenotypic-and-genotypic-resistance-profiles-of-multidrug-resistant-enterobacterial-clinical-isolates
#13
Lamis Galal, Neveen A Abdel Aziz, Walaa M Hassan
Fluoroquinolones and aminoglycosides offer effective therapy for extended-spectrum beta-lactamase (ESBL)-producing enterobacterial infections, but their usefulness is threatened by increasing resistant strains. OBJECTIVE: This study was conducted to demonstrate the phenotypic outcomes of the coexistence of genetic determinants mediating resistance to extended-spectrum cephalosporins and quinolones in enterobacterial isolates collected from patients with health-care-associated infections in Egypt...
May 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29747038/emerging-high-level-ciprofloxacin-resistance-and-molecular-basis-of-resistance-in-salmonella-enterica-from-humans-food-and-animals
#14
Dai Kuang, Jianmin Zhang, Xuebin Xu, Weimin Shi, Sheng Chen, Xiaowei Yang, Xudong Su, Xianming Shi, Jianghong Meng
Disease caused by nontyphoidal serotypes of Salmonella enterica is the leading cause of foodborne illness worldwide. Many serotypes have also developed resistance to antimicrobials commonly used for the treatment of salmonellosis. Here we analyze 179 ciprofloxacin-resistant isolates identified among 3680 Salmonella isolated from humans, food, animals, and water collected in Shanghai, China. They were assessed for antimicrobial susceptibility, plasmid-mediated quinolone resistance (PMQR) determinants, and mutations in quinolone resistance determination regions (QRDRs); genetic relatedness was examined using PFGE...
May 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29741998/serotype-and-antimicrobial-resistance-of-escherichia-coli-isolated-from-feces-of-wild-giant-pandas-ailuropoda-melanoleuca-in-sichuan-province-china
#15
Danyu Chen, Wencheng Zou, Shengze Xie, Linghan Kong, Yanpeng Chen, Xiuzhong Zhang, Jianan Li, Hongning Wang, Guangyang Cheng, Yue Qin, Xingyu Mu, Xin Yang
Escherichia coli is a major pathogen leading to systemic and enteric illnesses in wild giant pandas ( Ailuropoda melanoleuca). To investigate the characteristics and distribution of E. coli in wild giant pandas across four different nature reserves in Sichuan, Republic of China, we researched serotypes, phylogenetic groups, antimicrobial resistance, and resistance genes of E. coli not previously reported for wild giant pandas. A total of 82 E. coli isolates were identified from 40 fecal samples in August 2016 to May 2017...
May 9, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29741928/comparative-study-on-antibiotic-resistance-and-dna-profiles-of-salmonella-enterica-serovar-typhimurium-isolated-from-humans-retail-foods-and-the-environment-in-shanghai-china
#16
Zengfeng Zhang, Chenyang Cao, Bin Liu, Xuebin Xu, Yanfei Yan, Shenghui Cui, Sheng Chen, Jianghong Meng, Baowei Yang
We characterized antibiotic resistance profiles, antibiotic resistance-associated genes, and pulsed-field gel electrophoresis (PFGE) patterns of 145 Salmonella enterica serotype Typhimurium isolates from human infections and retail foods that were possibly responsible for salmonellosis outbreaks from 2008 to 2012 in Shanghai, China. Resistance to at least three antibiotics was found in 66.7% of chicken isolates, 76.5% of duck isolates, 77.8% of pork isolates, and 80.5% of human isolates. Seven antibiotic resistance phenotypes were detected in chicken isolates, 16 in pork isolates, 17 in duck isolates, and 50 in human isolates...
May 9, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29741238/effect-of-surface-modification-on-in-depth-transformations-and-flexural-strength-of-zirconia-ceramics
#17
Kan Wongkamhaeng, Deborah V Dawson, Julie A Holloway, Isabelle Denry
PURPOSE: Chairside surface adjustments of zirconia dental restorations enhance the toughening stress-induced tetragonal-to-monoclinic phase transformation and domain reorientation by ferro-elastic domain switching (FDS), but also trigger subsurface damage, which could compromise long-term clinical performance. The purpose of this study was to assess the depth of phase transformation, associated FDS, and flexural strength of dental zirconia (BruxZir HT 2.0), after chairside surface treatments...
May 9, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29738283/identification-of-chromosomes-in-thinopyrum-intermedium-and-wheat-th-intermedium-amphiploids-based-on-multiplex-oligonucleotide-probes
#18
Yu Cui, Yanping Zhang, Juan Qi, H Wang, Richard R-C Wang, Yinguang Bao, Xing-Feng Li
Synthesized oligonucleotides (oligos) can be used as effective probes similar to plasmid clones for chromosome identification in fluorescence in situ hybridization (FISH) analysis, making oligo FISH a simpler and more efficient molecular cytogenetic technique for studying plants. In this study, multiplex oligonucleotide probes, including pSc119.2-1, pAs1-4, (GAA)10, (AAC)6 and pTa71, were combined and used in FISH to identify chromosomes in common wheat, Thinopyrum intermedium and a wheat-Th. intermedium amphiploid TE256-1...
May 8, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29727265/prevalence-of-aminoglycoside-modifying-enzymes-in-escherichia-coli-and-klebsiella-pneumoniae-producing-extended-spectrum-%C3%AE-lactamases-collected-in-two-multicenter-studies-in-spain
#19
Marta Fernández-Martínez, Belén Ruiz Del Castillo, Maria Jesús Lecea-Cuello, Jesús Rodríguez-Baño, Álvaro Pascual, Luis Martínez-Martínez
The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated...
May 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29726902/the-role-of-cytochrome-p450-enzymes-in-carcinogen-activation-and-detoxication-an-in-vivo-in-vitro-paradox
#20
Lindsay Reed, Volker M Arlt, David H Phillips
Many chemical carcinogens require metabolic activation via xenobiotic-metabolising enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies, utilising reconstituted systems, microsomal fractions and cultured cells, implicate cytochrome P450 enzymes as being the predominant enzymes responsible for the metabolic activation of many procarcinogens. With the development of targeted gene disruption methodologies, knockout mouse models have been generated that allow investigation of the in-vivo roles of P450 enzymes in the metabolic activation of carcinogens...
May 3, 2018: Carcinogenesis
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