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Kashif Bashir, Romana Sarwar, Shazia Fatima, Soma Saeed, Ishrat Mahjabeen, Mahmood Akhtar Kayani
PURPOSE: Variants in DNA repair genes may alter the repair mechanisms that make the persons vulnerable to DNA damage. These polymorphic variants in the DNA repair pathway genes, such as XRCC1, have been associated with susceptibility of several types of cancer including thyroid cancer. This study was designed to explore the link between XRCC1 polymorphisms and modulation of thyroid cancer risk. METHODS: Our study consisted of 456 thyroid cancer patients and 400 controls...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
George Grunberger, Yehuda Handelsman, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, Richard A Haas, Victor L Roberts, Guillermo E Umpierrez
This document represents the official position of the American Association of Clinical Endocrinologists and American College of Endocrinology. Where there are no randomized controlled trials or specific U.S. FDA labeling for issues in clinical practice, the participating clinical experts utilized their judgment and experience. Every effort was made to achieve consensus among the committee members. Position statements are meant to provide guidance, but they are not to be considered prescriptive for any individual patient and cannot replace the judgment of a clinician...
March 2018: Endocrine Practice
María-Dolores Rey, Graham Moore, Azahara C Martín
Karyotypes of three accessions of <i>Hordeum chilense</i> (H1, H16 and H7), <i>Hordeum vulgare</i> and <i>Triticum aestivum</i> were characterized by physical mapping of several repetitive sequences. A total of fourteen repetitive sequences were used as probes for fluorescence in situ hybridization (FISH) with the aim of identifying inter- and intra-species polymorphisms. The (AG)12 and 4P6 probes only produced hybridization signals in wheat, the BAC7 probe only hybridized to the centromeric region of <i>H...
March 15, 2018: Genome Génome / Conseil National de Recherches Canada
Shivanjali Kumar, Kamal Kumar, Sarita Bajaj, Ranjana Kumar, Atul Gogia, Atul Kakar, Shrishti Paul Byotra
Introduction: Diabetes is a major world-wide healthcare problem. Cost effective markers for screening and diagnosis of T2DM are the need of the day especially in developing and under-developed countries. Simple anthropometric measurements may help us in identifying individuals likely to have diabetes. Material and Methods: Data from 1055 North-Indian subjects was analysed. Results: Out of several anthropometric measurements studied, Waist-Thigh ratio (WTR) correlated significantly and positively with all three measures of diabetes i...
January 2018: Indian Journal of Endocrinology and Metabolism
Anyun Zhang, Yunxia Li, Zhongbin Guan, Hongmei Tuo, Dan Liu, Yanxian Yang, Changwen Xu, Changwei Lei, Hongning Wang
The aim of this study was to evaluate the influence of apramycin administration on the development of antibiotic resistance in Escherichia coli ( E. coli ) strains isolated from chicken feces and houseflies under field conditions. Chickens in the medicated group ( n = 25,000) were given successive prophylactic doses (0.5 mg/l) of apramycin in their drinking water from Days 1 to 5, while no antibiotics were added to the un-medicated groups drinking water ( n = 25,000). Over 40 days, a total of 1170 E. coli strains were isolated from fecal samples obtained from medicated and un-medicated chickens and houseflies from the same chicken farm...
2018: Frontiers in Microbiology
Juan Xu, Haiqing Wu, Songwen Chen, Baozhen Qi, Genqing Zhou, Lidong Cai, Liqun Zhao, Yong Wei, Shaowen Liu
Atrial fibrosis serves as an important contributor to atrial fibrillation (AF). Recent data have suggested that microRNA-30c (miR-30c) is involved in fibrotic remodelling and cancer development, but the specific role of miR-30c in atrial fibrosis remains unclear. The purpose of this study was to investigate the role of miR-30c in atrial fibrosis and its underlying mechanisms through in vivo and in vitro experiments. Our results indicate that miR-30c is significantly down-regulated in the rat abdominal aortic constriction (AAC) model and in the cellular model of fibrosis induced by transforming growth factor-β1 (TGF-β1)...
March 13, 2018: Journal of Cellular and Molecular Medicine
Thi Thu Hang Pham, Pierre Rossi, Hoang Dang Khoa Dinh, Ngoc Tu Anh Pham, Phuong Anh Tran, To Thi Khai Mui Ho, Quoc Tuc Dinh, Luiz Felippe De Alencastro
In Vietnam, intensive shrimp farms heavily rely on a wide variety of antibiotics (ABs) to treat animals or prevent disease outbreak. Potential for the emergence of multi-resistant bacteria is high, with the concomitant contamination of adjacent natural aquatic habitats used for irrigation and drinking water, impairing in turn human health system. In the present study, quantification of AB multi-resistant bacteria was carried out in water and sediment samples from effluent channels connecting a shrimp farming area to the Vam Co River (Long An Province, Vietnam)...
March 7, 2018: Journal of Environmental Management
Anna Lena Zogg, Katrin Zurfluh, Sarah Schmitt, Magdalena Nüesch-Inderbinen, Roger Stephan
Among 64 uropathogenic Escherichia coli (UPEC) isolated from 13 cats and 51 dogs, 35 were extended-spectrum beta-lactamase (ESBL) producers, and 29 were non-ESBL producers. Forty-six (71.9%) of the isolates were multidrug resistant (MDR). Among the ESBL producers, blaCTX-M-15 (n = 17/48.6% of the blaESBLs ), blaCTX-M-1 (n = 10/28.6%), blaCTX-M-55 (n = 4/11.4%), blaCTX-M-14 (n = 3/8.6%), and blaCTX-M-27 (n = 1/2.9%) were identified. The plasmid-mediated fluoroquinolone resistance genes aac(6')-Ib-cr, qnrB and the azithromycin resistance gene mph(A) were detected in 17 (26...
March 2018: Veterinary Microbiology
Anno de Jong, Anaëlle Muggeo, Farid El Garch, Hilde Moyaert, Christophe de Champs, Thomas Guillard
ComPath is an ongoing European programme dedicated to monitor antibiotic susceptibility of bacterial pathogens from diseased dogs and cats. The objective was to characterize determinants associated with quinolone resistance among 160 enrofloxacin non-wild type strains (100 Escherichia coli, 45 Proteus mirabilis, 14 Klebsiella pneumoniae, 1 Enterobacter cloacae) selected among 843 non-duplicate Enterobacteriaceae isolates collected in 12 European countries (2013-2014). These strains with non-wild type MICs of ≥0...
March 2018: Veterinary Microbiology
Zachary E Stiles, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, Lei Dong, Jim Y Wan, Michael G Martin, Paxton V Dickson
BACKGROUND AND OBJECTIVES: Outcomes and recommendations regarding adjuvant therapy (AT) for stage I ampullary adenocarcinoma (AAC) are inadequately described. We sought to determine factors associated with survival and better define the impact of AT. METHODS: The NCDB was queried for stage I AAC patients undergoing resection. We evaluated variables influencing the administration of AT and affecting survival, including the receipt of AT. RESULTS: Five hundred thirty-seven patients were identified...
March 8, 2018: Journal of Surgical Oncology
Cori Russell, Samip Sheth, Douglas Jacoby
PURPOSE OF REVIEW: We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 American College of Cardiology Cholesterol Guidelines. Second, we examine the clinical utility of non-statin agents alone and in combination in terms of LDL-C lowering and ASCVD risk reduction...
March 7, 2018: Current Atherosclerosis Reports
Ivan Wong, Laurie Hiemstra, Olufemi R Ayeni, Alan Getgood, Cole Beavis, Monika Volesky, Ross Outerbridge, Brendan Sheehan, Robert McCormack, Robert Litchfield, Daniel Whelan, Nicholas Mohtadi, Catherine Coady, Peter B MacDonald
No abstract text is available yet for this article.
February 2018: Orthopaedic Journal of Sports Medicine
Kelsey Mandak, Janice Light
This study used an online focus group to examine the beliefs and practices of school-based speech-language pathologists (SLPs) who served children with complex communication needs regarding their provision of family-centered services. Participants revealed that despite their desire for family involvement and reported beliefs in the importance of family-centered services, there were barriers in place that often limited family-centered service provision. Across the SLPs, many were dissatisfied with their current provision of family-centered services...
March 5, 2018: Augmentative and Alternative Communication: AAC
Christine Holyfield, Jessica Gosnell Caron, Kathryn Drager, Janice Light
PURPOSE: Visual scene displays (VSDs) and just-in-time programming supports are augmentative and alternative communication (AAC) technology features with theoretical benefits for beginning communicators of all ages. The goal of the current study was to evaluate the effects of a communication application (app) on mobile technology that supported the just-in-time programming of VSDs on the communication of preadolescents and adolescents who were beginning communicators. METHOD: A single-subject multiple-baseline across participant design was employed to evaluate the effect of the AAC app with VSDs programmed just-in-time by the researcher on the communication turns expressed by five preadolescents and adolescents (9-18 years old) who were beginning communicators...
March 5, 2018: International Journal of Speech-language Pathology
Ana Verónica Martínez-Vázquez, Gildardo Rivera-Sánchez, Krystal Lira Méndez, Miguel Ángel Reyes-López, Virgilio Bocanegra-García
OBJECTIVE: The aim of this work was to determinate the prevalence of Escherichia coli and its resistance to antimicrobials and the presence of virulence genes in retail samples of beef and pork in several locations in Tamaulipas. METHODS: In this work, a total of 106 samples (beef and pork) collected from August 2013 to March 2014, were analyzed to detect Escherichia coli and then analyzed for virulence, antibiotic resistance gene detection, and tested for susceptibility to 16 antimicrobials...
February 28, 2018: Journal of Global Antimicrobial Resistance
Anne M Mills, Lauren C Peres, Alice Meiss, Kari L Ring, Susan C Modesitt, Sarah E Abbott, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa L Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Edward S Peters, Ann G Schwartz, Paul D Terry, Kristin Wallace, Joellen M Schildkraut
African American women with high-grade serous ovarian carcinoma have worse outcomes compared with women of European descent. Although the discrepancy is partially attributed to differences in access to care, the tumor immune microenvironment may also contribute. Expression of targetable immune regulatory molecules such as programmed cell death ligand-1 (PD-L1) and indoleamine 2,3 dioxygenase (IDO) is of particular interest as it may help guide therapy in this population. Using cases from the largest study of African American women with ovarian cancer, the African American Cancer Epidemiology Study, we characterized PD-L1 and IDO expression in 112 high-grade serous ovarian carcinomas...
February 26, 2018: International Journal of Gynecological Pathology
Monika Dolejska, Costas C Papagiannitsis, Matej Medvecky, Lenka Davidova-Gerzova, Adam Valcek
The complete nucleotide sequences of six IMP-4-encoding plasmids recovered from Enterobacteriaceae of wildlife origin were characterized. Sequencing data showed that plasmids of different incompatibility groups (IncM, IncI1, IncF, and nontypeable [including an IncX5_2 and two pPrY2001-like]) carried the bla IMP-4 -carrying integrons, In809 or In1460. Most of the plasmids carried mph (A) region, and chrA -like, aac(3)-IId and bla TEM-1b genes. Finally, plasmid analysis revealed the involvement of two different, IS 26 - and Tn 1696 -associated, mechanisms in the mobilization of IMP-4-encoding integrons...
February 26, 2018: Antimicrobial Agents and Chemotherapy
Shahram Mobaraki, Mohammad Aghazadeh, Mohammad Hossein Soroush Barhaghi, Mohammad Yousef Memar, Hamid Reza Goli, Pourya Gholizadeh, Hossein Samadi Kafil
BACKGROUND: The presence of Class 1, 2 and 3 integrons in clinical isolates of Pseudomonas aeruginosa with multi-drug resistance phenotype has rendered the organism as a new concern. OBJECTIVE: This study aimed to investigate the prevalence of Class 1, 2 and 3 integrons in multi-drug resistant clinical isolates of Pseudomonas aeruginosa collected from hospitals in the city of Tabriz Materials and Methods: A total of 200 P. aeruginosa non-duplicated clinical isolates were collected from inpatients and outpatients in different wards of hospitals from May to November 2016...
March 2018: BioMedicine
Mónica Cerezales, Alain A Ocampo-Sosa, Laura Álvarez Montes, Catalina Díaz Ríos, Zulema Bustamante, Jazmín Santos, Luis Martínez-Martínez, Paul G Higgins, Lucía Gallego
Acinetobacter baumannii causes serious hospital-acquired infections and has been positioned as a priority organism by the World Health Organization. This study includes 36 A. baumannii isolates from a children hospital recovered between March 2014 and May 2015 in Cochabamba. The majority of the isolates were recovered from blood cultures (n=10, 31.3%) and respiratory samples (n=11, 34.4%); fifty three percent of the patients were younger than one month old. Most of these isolates (n=30, 80.6%) were extremely-drug resistant (XDR) and 8...
February 22, 2018: Pediatric Infectious Disease Journal
Orsolya Szabó, Dániel Gulyás, Nikolett Szabó, Katalin Kristóf, Béla Kocsis, Dóra Szabó
Plasmid-mediated quinolone resistance (PMQR) determinants including, qnrA, qnrB, qnrC, qnrD, qnrS, aac(6')-Ib-cr, oqxAB, and qepA, were investigated in 214 Enterobacteriaceae strains from urine clinical samples. Antimicrobial susceptibility testing for ciprofloxacin, ceftriaxone, and imipenem was performed by broth microdilution method. All strains were screened for PMQR genes by PCR. Virulence determinants, namely afa, pap, pil, sfa/foc, and kpsMT of eight Escherichia coli strains proven positive for at least one qnr gene, were investigated by PCR...
February 23, 2018: Acta Microbiologica et Immunologica Hungarica
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