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https://www.readbyqxmd.com/read/29148877/characterization-and-horizontal-transfer-of-antimicrobial-resistance-genes-and-integrons-in-bacteria-isolated-from-cooked-meat-products-in-china
#1
Tao Yu, Xiaobing Jiang, Yu Liang, Yanping Zhu, Jinhe Tian, Hao Ying, Xuannian Wang, Lei Shi
The aim of this study was to investigate antimicrobial resistance and the presence and transferability of corresponding resistance genes and integrons in bacteria isolated from cooked meat samples in the People's Republic of China. A total of 150 isolates (22 species belonging to 15 genera) were isolated from 49 samples. Resistance of these isolates to antimicrobials was commonly observed; 42.7, 36.0, and 25.3% of the isolates were resistant to tetracycline, streptomycin, and ampicillin, respectively. Multidrug resistance was observed in 41 (27...
November 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29145257/clinical-features-of-acute-acquired-comitant-esotropia-in-the-chinese-populations
#2
Tao Fu, Jing Wang, Moran Levin, Ping Xi, Dongguo Li, Junfa Li
Acute acquired comitant esotropia (AACE) is an unusual presentation of esotropia that occurs after infancy. This study was aimed to study the clinical features and the differences between children and adult patients with AACE in the Chinese populations.This was a retrospective analysis of patients diagnosed with AACE over 4 years; 69 patients (25 females and 44 males) were identified. The patients were divided into 3 groups: < 10 year-old (n = 6, 8.7%), 10-18 year-old (n = 23, 33.3%), and ≥18 year-old (n = 40, 58...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29138023/oleanonic-acid-ameliorates-pressure-overload-induced-cardiac-hypertrophy-in-rats-the-role-of-pkc%C3%AE-nf-%C3%AE%C2%BAb-pathway
#3
Hui Gao, Hui Liu, Tiexin Tang, Xiaofei Huang, Dongxiu Wang, Yan Li, Pan Huang, Yingfu Peng
It has been reported that inflammation is closely related with cardiac hypertrophy. Some inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 directly induce cardiac hypertrophy, which is associated with the activation of nuclear factorkappa B (NF-κB). Thus, NF-κB is an attractive target for cardiac hypertrophy. In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-κB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes...
November 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29137983/transcriptional-regulation-of-acetoacetyl-coa-synthetase-by-sp1-in-neuroblastoma-cells
#4
Shinya Hasegawa, Masahiko Imai, Masahiro Yamasaki, Noriko Takahashi, Tetsuya Fukui
Acetoacetyl-CoA synthetase (AACS) is the enzyme responsible for cholesterol and fatty acid synthesis in the cytosol. We have previously shown that AACS has an important role in normal neuronal development and that knockdown of SREBP-2, which orchestrates cholesterol synthesis, resulted in the downregulation of AACS mRNA levels. In this study, we investigated the transcriptional mechanism of AACS in Neuro-2a, neuroblastoma cells. Luciferase assay showed that the minimal core promoter of the mouse AACS gene is located in a region with 110 bps upstream from the transcription start site...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29136156/increase-in-antimicrobial-resistance-and-emergence-of-major-international-high-risk-clonal-lineages-in-dogs-and-cats-with-urinary-tract-infection-16-year-retrospective-study
#5
Cátia Marques, Adriana Belas, Andreia Franco, Catarina Aboim, Luís Telo Gama, Constança Pomba
Objectives: To evaluate temporal trends in antimicrobial resistance, over 16 years, in bacteria isolated from dogs and cats with urinary tract infection (UTI) and the clonal lineages of bacteria harbouring critical antimicrobial resistance mechanisms. Methods: Antimicrobial susceptibility testing was conducted for 948 bacteria isolated from dogs and cats with UTI (1999-2014). Resistance mechanisms were detected by PCR, namely ESBL/AmpC in third-generation cephalosporin (3GC)-resistant Escherichia coli and Proteus mirabilis, mecA in methicillin-resistant staphylococci, and aac(6')-Ieaph(2″)-Ia and aph(2″)-1d in high-level gentamicin-resistant (HLGR) enterococci...
November 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29132547/distribution-of-genes-encoding-resistance-to-aminoglycoside-modifying-enzymes-in-methicillin-resistant-staphylococcus-aureus-mrsa-strains
#6
Azar Dokht Khosravi, Atefeh Jenabi, Effat Abbasi Montazeri
Today Methicillin-Resistant Staphylococcus aureus (MRSA) have acquired multiple resistance to a wide range of antibiotics including aminoglycosides. So, this study was aimed to investigate the rate of aminoglycoside resistance and the frequency of aminoglycoside resistance mediated genes of aac(Ia)-2, aph(3)-IIIa and ant(4')-Ia among MRSA strains. A total of 467 staphylococci isolates were collected from various clinical samples. S. aureus strains were identified by standard culture and identification criteria and investigating of presence of 16S rRNA and nuc genes...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29127051/genomic-analysis-of-in-vivo-acquired-resistance-to-colistin-and-rifampin-in-acinetobacter-baumannii
#7
Nadia Jaidane, Thierry Naas, Wejdene Mansour, Bechir Ben Radhia, Sofiene Jerbi, Noureddine Boujaafar, Olfa Bouallegue, Rémy A Bonnin
Acinetobacter baumannii is an opportunistic pathogen in health-care facilities responsible for nosocomial infections mostly in immune-compromised patients. Colistin resistance is increasingly reported worldwide in that species. We describe here in vivo selection of colistin and rifampin resistance in a carbapenem-resistant A. baumannii (Ab). Antimicrobial susceptibility testing, plasmid analysis, and Whole Genome Sequencing (WGS) were performed to fully characterize the resistome of AbS1 and AbS2 clinical isolates...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29125290/effect-of-ionic-functional-groups-on-the-oxidation-state-and-interfacial-binding-property-of-catechol-based-adhesive
#8
Ameya R Narkar, Jonathan D Kelley, Rattapol Pinnaratip, Bruce P Lee
Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide (DMA) with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the production of hydrogen peroxide (H2O2) byproduct generated during the autoxidation of catechol while the interfacial binding property of the adhesive was determined by performing Johnson-Kendall-Roberts (JKR) contact mechanics tests tested over a wide range of pH values (pH 3-9)...
November 10, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29116391/role-of-percutaneous-cholecystostomy-for-acute-acalculous-cholecystitis-clinical-outcomes-of-271-patients
#9
Seung Yeon Noh, Dong Il Gwon, Gi-Young Ko, Hyun-Ki Yoon, Kyu-Bo Sung
OBJECTIVES: To examine the outcomes of percutaneous cholecystostomy (PC) in patients with acute acalculous cholecystitis (AAC). METHODS: The study population comprised 271 patients (mean age, 72 years; range, 22-97 years, male, n=169) with AAC treated with PC with or without subsequent cholecystectomy. Clinical data from total 271 patients were analysed, and outcomes were assessed according to whether the catheter was removed or remained indwelling. Patient survival and recurrence rates were calculated...
November 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29113933/spread-of-klebsiella-pneumoniae-st395-non-susceptible-to-carbapenems-and-resistant-to-fluoroquinolones-in-north-eastern-france
#10
Anaëlle Muggeo, Thomas Guillard, Frédéric Klein, Fany Reffuveille, Caroline François, Anamaria Babosan, Odile Bajolet, Xavier Bertrand, Christophe de Champs
Fluoroquinolones (FQ) are potential treatments to treat infections from extended-spectrum β-lactamase producing-Enterobacteriaceae susceptible to FQ. Due to increasing non-susceptibility to carbapenems among Enterobacteriaceae, we characterized FQ resistance mechanisms in 36 Klebsiella pneumoniae isolates that are non-susceptible to ertapenem in North-Eastern France in 2012 and described the population structure by pulsed field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Among them, 36% (13/36) carried a carbapenemase encoding-gene...
November 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29111483/involvement-of-topoisomerase-mutations-qnr-and-aac-6-ib-cr-genes-in-conferring-quinolone-resistance-to-the-clinical-isolates-of-vibrio-and-shigella-spp-1998-to-2009-from-kolkata-india
#11
Kittappa Vinothkumar, Shaileshkumar R Bhalara, Aneri Shah, Thandavarayan Ramamurthy, Swapan Kumar Niyogi, G Naresh Kumar, Ashima Kushwaha Bhardwaj
BACKGROUND: Quinolone antibiotics have been widely used to treat diarrheal diseases caused by the bacterial agents such as those belonging to Vibrio spp. and Shigella spp. As these pathogens are accumulating quinolone resistance, treating the infections caused by them has become complicated. METHODS AND RESULTS: In this study, isolates of Vibrio and Shigella species, obtained from the diarrhea patients from Kolkata, India were analyzed for quinolone resistance. In total, nine V...
October 27, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29109958/deterioration-of-cerebral-oxygenation-by-aortic-arch-calcification-progression-in-patients-undergoing-hemodialysis-a-cross-sectional-study
#12
Kiyonori Ito, Susumu Ookawara, Tomohisa Okochi, Yuichiro Ueda, Masaya Kofuji, Hideyuki Hayasaka, Takayuki Uchida, Haruhisa Miyazawa, Katsunori Yanai, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Keiji Hirai, Yoshio Kaku, Taro Hoshino, Osamu Tanaka, Kaoru Tabei, Yoshiyuki Morishita
Background: Near-infrared spectroscopy revealed that the regional saturation of oxygen (rSO2) in cerebral tissue is lower in hemodialysis (HD) patients than in healthy subjects. However, no study has examined the changes in cerebral oxygenation by aortic arch calcification (AAC) progression in HD patients. Methods: A total of 104 HD patients were divided into four groups by AAC grade determined using chest radiography: 23 patients at grade 0, 24 at grade 1, 30 at grade 2, and 27 at grade 3...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29109167/cloning-and-expression-of-novel-aminoglycoside-phosphotransferase-genes-from-campylobacter-and-their-role-in-the-resistance-to-six-aminoglycosides
#13
S Zhao, S Mukherjee, C Li, S B Jones, S Young, P F McDermott
Nine aph genes, including aph(2″)-Ib, Ic, Ig, If, If1, If3, Ih, aac(6')-Ie/aph(2″)-Ia, and aac(6')-Ie/aph(2″)-If2 were previously identified in Campylobacter. To measure the contribution of these alleles to aminoglycoside resistance, we cloned nine genes into the pBluescript and expressed them in E. coli DH5α. The nine aph expressed in E.coli showed varying levels of resistance to gentamicin, kanamycin and tobramycin. Three genes, aac(6″)-Ie/aph(2″)-Ia, aph2″-If1 and aph2″-Ig showed increased MICs to amikacin and five aph genes were transferrable...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29107607/emergence-and-mechanism-of-carbapenem-resistant-escherichia-coli-in-henan-china-2014
#14
Wen-Juan Liang, Hui-Ying Liu, Guang-Cai Duan, Yong-Xin Zhao, Shuai-Yin Chen, Hai-Yan Yang, Yuan-Lin Xi
The emergence and dissemination of carbapenem-resistant Escherichia coli (E. coli) strains is a main risk for global public health, but little is known of carbapenemase producing E. coli in Henan, China. The study was undertaken to investigate the prevalence and mechanism of carbapenem-resistant E. coli strains in a hospital in Xinxiang, Henan, China, 2014. A total of 5 carbapenemase-producing E. coli strains were screened from 1014 isolates. We found that they were all resistant to meropenem and imipenem. Amikacin showed the best sensitivity, with gentamicin coming up next...
October 26, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29106817/application-of-the-aace-ace-advanced-framework-for-the-diagnosis-of-obesity-and-cardiometabolic-disease-staging-in-a-general-population-from-three-regions-of-venezuela-the-vemsols-study-results
#15
Ramfis Nieto-Martínez, Juan P González-Rivas, Eunice Ugel, Imperia Brajkovich, Alejandro Risquez, W Timothy Garvey, Jeffrey I Mechanick
OBJECTIVE: To determine the prevalence of obesity according to the AACE/ACE framework based on a complications-centric model with further application of the Cardiometabolic Disease Staging (CMDS) system in Venezuelan population. METHODS: 1,320 adults were randomly selected from 3 regions. AACE/ACE framework definitions: overweight: body mass index (BMI) 25 to 29.9 kg/m(2) and no obesity-related complications (ORC); obesity stage 0: BMI ≥ 30 and no ORC; stage 1: BMI ≥ 25 and one or more mild-to-moderate ORC; and stage 2: BMI ≥ 25 and one or more severe ORC...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29106816/insulin-glargine-300-u-ml-is-associated-with-less-weight-gain-while-maintaining-glycemic-control-and-low-risk-of-hypoglycemia-compared-with-insulin-glargine-100-u-ml-in-an-aging-population-with-type-2-diabetes
#16
Medha N Munshi, Jasvinder Gill, Jason Chao, Elena V Nikonova, Meenakshi Patel
OBJECTIVE: Assess efficacy, hypoglycemia and weight gain in patients with type 2 diabetes (T2D) treated with insulin glargine 300 U/mL (Gla-300) or 100 U/mL (Gla-100) across different age groups. METHODS: Pooled data were generated for patients randomized to Gla-300 or Gla-100 in the EDITION 2 (NCT01499095) and 3 (NCT01676220) studies. In four age groups (<55, ≥55 to <60, ≥60 to <65, ≥65 years), glycated hemoglobin A1C (A1C), percentage of patients reaching A1C <7...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29091187/quantitative-and-automated-maldi-tof-ms-based-detection-of-the-plasmid-mediated-quinolone-resistance-determinant-aac-6-ib-cr-in-enterobacteriaceae
#17
Marina Oviaño, Marta Gómara, Maria José Barba, Katrin Sparbier, Álvaro Pascual, Germán Bou
No abstract text is available yet for this article.
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29091185/genomic-sequences-of-streptococcus-agalactiae-with-high-level-gentamicin-resistance-collected-in-the-bsac-bacteraemia-surveillance
#18
Michel Doumith, Shazad Mushtaq, Veronique Martin, Aiysha Chaudhry, Rachael Adkin, Juliana Coelho, Vicki Chalker, Alasdair MacGowan, Neil Woodford, David M Livermore
Background: Like other streptococci, Streptococcus agalactiae typically has intrinsic low-level aminoglycoside resistance. High-level gentamicin resistance was seen in 2 of 1125 isolates collected in the BSAC Bacteraemia Surveillance Programme between 2001 and 2014. These organisms, both isolated in 2014, were characterized. Methods: Identifications were by latex agglutination, MICs by BSAC agar dilution and sequencing by Illumina methodology. Results: Gentamicin MICs were >1024 mg/L versus a species mode of 8 mg/L; both isolates also were unusually ciprofloxacin resistant with MICs of 64 mg/L versus a species mode of 1 mg/L...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29081769/characterization-of-oqxab-in-escherichia-coli-isolates-from-animals-retail-meat-and-human-patients-in-guangzhou-china
#19
Jing Wang, Chan-Ping Zhi, Xiao-Jie Chen, Ze-Wen Guo, Wu-Ling Liu, Juan Luo, Xin-Yi Huang, Li Zeng, Jia-Wei Huang, Ying-Bi Xia, Meng-Ying Yi, Teng Huang, Zhen-Ling Zeng, Jian-Hua Liu
The purpose of this study was to investigate the prevalence and genetic elements of oqxAB among Escherichia coli isolates from animals, retail meat, and humans (patients with infection or colonization) in Guangzhou, China. A total of 1,354 E. coli isolates were screened for oqxAB by PCR. Fifty oqxAB-positive isolates were further characterized by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), S1-PFGE, genetic environment analysis, plasmid replicon typing, and plasmid sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29079079/assessing-cognitive-functioning-in-females-with-rett-syndrome-by-eye-tracking-methodology
#20
Jaana Ahonniska-Assa, Orli Polack, Einat Saraf, Judy Wine, Tamar Silberg, Andreea Nissenkorn, Bruria Ben-Zeev
BACKGROUND: While many individuals with severe developmental impairments learn to communicate with augmentative and alternative communication (AAC) devices, a significant number of individuals show major difficulties in the effective use of AAC. Recent technological innovations, i.e., eye-tracking technology (ETT), aim to improve the transparency of communication and may also enable a more valid cognitive assessment. OBJECTIVES: To investigate whether ETT in forced-choice tasks can enable children with very severe motor and speech impairments to respond consistently, allowing a more reliable evaluation of their language comprehension...
October 10, 2017: European Journal of Paediatric Neurology: EJPN
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