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https://www.readbyqxmd.com/read/29352277/influence-of-early-stress-on-memory-reconsolidation-implications-for-post-traumatic-stress-disorder-treatment
#1
Hélène Villain, Aïcha Benkahoul, Philippe Birmes, Barbara Ferry, Pascal Roullet
Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals. Following this, in an open-label study 70% of patients with PTSD treated with propranolol during reactivation of traumatic memory exhibited full remission. However, the reason why 30% of these patients did not respond positively to propranolol treatment is still unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29352260/effect-of-in-vitro-storage-duration-on-measured-mechanical-properties-of-brain-tissue
#2
Wei Zhang, Li-Fu Liu, Yue-Jiao Xiong, Yi-Fan Liu, Sheng-Bo Yu, Cheng-Wei Wu, Weihong Guo
Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this study is to investigate the effect of in vitro storage duration on the mechanical performance of brain tissue since measurements are usually carried out in vitro. Differential Scanning Calorimetry (DSC) measurements and uniaxial compression mechanical experiments are carried out...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351875/trunk-and-pelvic-dynamics-during-transient-turns-among-individuals-with-unilateral-traumatic-lower-limb-amputation
#3
Pawel R Golyski, Brad D Hendershot
Prior work has identified alterations in trunk-pelvic dynamics with lower limb amputation (LLA) during in-line walking; however, evaluations of other ambulatory tasks are limited. Turns are ubiquitous in daily life but can be challenging for individuals with LLA, prompting additional or unique proximal compensations when changing direction, which over time may lead to development of low back pain. We hypothesized such proximal kinematic differences between persons with and without LLA would exist in the sagittal and frontal planes...
January 16, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29351760/glycaemic-control-targets-after-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#4
Jeroen Hermanides, Mark P Plummer, Mark Finnis, Adam M Deane, Jonathan P Coles, David K Menon
BACKGROUND: Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU). METHODS: We systematically searched MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials to November 2016. Outcomes of interest included ICU and in-hospital mortality, poor neurological outcome, the incidence of hypoglycaemia and infective complications...
January 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29351709/-validation-of-the-screening-for-complex-ptsd-skptbs-revision
#5
Florence Dorr, Martin Sack, Jürgen Bengel
BACKGROUND: The aim was to develop further a screening instrument for complex posttraumatic stress disorder (cPTSD). The screening for cPTSD (SkPTBS) tests a) potential traumatic experiences, b) influential features and risk factors, and c) symptoms of cPTSD. The SkPTBS by Dorr et al. (2016) was revised according to the current ICD-11 criteria set proposal for cPTSD and is explored in its revised edition. METHOD: Impacts of long-lasting interpersonal trauma were tested in inpatients of psychosomatic rehabilitation and in patients consulting a university outpatient center for trauma therapy...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351678/endoscopic-transcranial-duraplasty-for-rhinoliquorrhea-a-cadaveric-study
#6
Andrea Bartoli, Jean H Fasel, Karl Schaller, Max Jägersberg
BACKGROUND: Repair of the anterior skull base for cerebrospinal fluid leak requires either endoscopic endonasal approach or open transcranial approach. OBJECTIVE: To present a less invasive surgical procedure for sealing of the entire anterior fossa floor for traumatic rhinoliquorrhea. METHODS: Cadaver study in 3 head specimens. Endoscopic placement of a furled bovine pericardial patch bilaterally along the sphenoid ridge and planum in guidewire technique...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351381/frontal-assessment-battery-fab-performance-following-traumatic-brain-injury-hospitalized-in-an-acute-care-setting
#7
Natalia Rojas, Maude Laguë-Beauvais, Arielle Belisle, Julie Lamoureux, Ghusn AlSideiri, Judith Marcoux, Mohammed Maleki, Abdulrahman Y Alturki, Sonia Anchouche, Hanan Alquraini, Mitra Feyz, Elaine de Guise
The Frontal Assessment Battery (FAB) has been shown to be useful in several clinical settings. The aim of the present study was to examine the performance of patients with traumatic brain injury (TBI) on the FAB and to predict their acute outcome. The FAB was administered to 89 patients with mild (27 = uncomplicated and 39 = complicated) and moderate (n = 23) TBI during hospitalization in an acute care setting. The length of stay in days (LOS), Glasgow Outcome Scale-Revised score (GOSE) and Disability Rating Scale (DRS) score were collected...
January 19, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29351181/cleft-palate-repair-description-of-an-approach-its-evolution-and-analysis-of-post-operative-fistulas
#8
Raymond W Tse, Babette Siebold
BACKGROUND: Fistulas following cleft palate repair impair speech, health, and hygiene and occur in up to 35% cases. The purpose of this study was to (1) describe the evolution of a surgical approach to cleft palate repair; (2) assess the rates, causes, and predictive factors of fistulas; (3) assess the temporal association of modifications to fistula rates during six years of a single surgeon experience. METHODS: Consecutive patients (N=146) undergoing cleft palate repair were included...
January 12, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29351125/central-inhibition-of-granulocyte-macrophage-colony-stimulating-factor-is-analgesic-in-experimental-neuropathic-pain
#9
Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessell
With less than 50% of patients responding to the current standard of care and poor efficacy and selectivity of current treatments, neuropathic pain continues to be an area of considerable unmet medical need. Biological therapeutics such as monoclonal antibodies (mAbs) provide better intrinsic selectivity; however, delivery to the central nervous system (CNS) remains a challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well described in inflammation-induced pain, and early-phase clinical trials evaluating its antagonism have exemplified its importance as a peripheral pain target...
January 16, 2018: Pain
https://www.readbyqxmd.com/read/29350671/visits-for-alcohol-related-problems-in-a-large-urban-emergency-department-results-of-a-15-year-survey
#10
Ivan Comelli, Giuseppe Lippi, Fabian Sanchis-Gomar, Gianni Turcato, Gianfranco Cervellin
Alcohol abuse is associated with a high burden of morbidity and mortality. Nevertheless, definitive epidemiological data on alcohol-related visits in the emergency department (ED) is substantially lacking. This study was aimed to analyze the epidemiological patterns and temporal trends of alcohol-related visits in the local ED, and assessing the healthcare burden of cases needing hospital admission. All patients visited for alcohol-related problems between the years 2002-2016 were anonymously identified from the hospital database...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350644/talar-fractures-radiological-and-ct-evaluation-and-classification-systems
#11
Giuseppe Caracchini, Michele Pietragalla, Alioscia De Renzis, Michele Galluzzo, Mattia Carbone, Marcello Zappia, Anna Russo, Federico Greco, Vittorio Miele
INTRODUCTION: The talus is the second largest bone of the foot. It is fundamental to ensure normal ankle-foot movements as it connects the leg and the foot. Talar fractures are usually due to high energy traumas (road accidents, high level falls). They are not common as they account for 3-5% of ankle and foot fractures and 0.85% of all body fractures. However, talar fractures not correctly diagnosed and treated can lead to avascular necrosis of the astragalus, pseudoarthrosis, early osteoarthrisis and ankle instability, declining the quality of life of patients...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350641/traumatic-fractures-in-adults-missed-diagnosis-on-plain-radiographs-in-the-emergency-department
#12
Antonio Pinto, Daniela Berritto, Anna Russo, Federica Riccitiello, Martina Caruso, Maria Paola Belfiore, Vito Roberto Papapietro, Marina Carotti, Fabio Pinto, Andrea Giovagnoni, Luigia Romano, Roberto Grassi
Radiography remains the imaging standard for fracture detection after trauma. The radiographic diagnosis of most fractures and dislocations poses little difficulty to radiologists: however, occasionally these injuries are quite subtle or even impossible to detect on radiographs. Missed diagnoses of fracture potentially have important consequences for patients, clinicians, and radiologists. Radiologists play a pivot role in the diagnostic assessment of the trauma patients: emergency radiologists who are more practiced at seeking out and discerning traumatic fractures can provide an invaluable service to their clinical colleagues by ensuring that patients do not endure delayed diagnoses...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350640/scapular-fractures-a-common-diagnostic-pitfall
#13
Daniela Berritto, Antonio Pinto, Anna Russo, Fabrizio Urraro, Antonella Laporta, Maria Paola Belfiore, Roberto Grassi
Scapular fractures are one of the most difficult fractures to diagnose on radiographs. Detection can be challenging because of the obscuration by the overlying structures or incomplete imaging due to difficult patient collaboration. Familiarity with imaging characteristics of these abnormalities will allow radiologists to better diagnose and characterize scapular fractures. Three-dimensional computed tomographic scans are considered the gold standard for scapular diagnoses. Treatment strategies differ depending on the type of scapular fractures, but the site and degree of displacement will determine whether surgical intervention should be considered...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350639/dynamic-mri-in-the-evaluation-of-the-spine-state-of-the-art
#14
Giulia Michelini, Antonella Corridore, Silvia Torlone, Federico Bruno, Claudia Marsecano, Raffaella Capasso, Ferdinando Caranci, Antonio Barile, Carlo Masciocchi, Alessandra Splendiani
INTRODUCTION: Degenerative disease of the spine is a generic term encompassing a wide range of different disease processes, which leads to spinal instability; traumatic/neoplastic events can accelerate this aging process. Therefore, the dynamic nature of the spine and its mobility across multiple segments is difficult to depict with any single imaging modality. METHODS: A review of PubMed databases for articles published about kMRI in patients with cervical and lumbar spinal desease was performed...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350593/the-natural-history-of-complete-spinal-cord-injury-a-pooled-analysis-of-1162-patients-and-a-meta-analysis-of-modern-data
#15
Najib E El Tecle, Nader S Dahdaleh, Mohamad Bydon, Wilson Z Ray, James C Torner, Patrick W Hitchon
OBJECTIVE The natural history of complete spinal cord injury (SCI) is poorly studied. The classically quoted rate of improvement or conversion for patients with American Spinal Injury Association (ASIA) grade A (ASIA A) injuries is 15%-20%; however, data supporting this rate are very limited. In this paper, the authors conducted a meta-analysis of modern data reporting on ASIA A patients and evaluated factors affecting the natural history of the disease. METHODS The authors conducted a systematic literature review of all randomized clinical trials (RCTs) and observational studies of patients with traumatic SCI...
January 19, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29350555/outcomes-of-latarjet-procedure-compared-with-bankart-repair-for-recurrent-traumatic-anterior-shoulder-instability
#16
Kellie C Huxel Bliven, Gail P Parr
Reference/Citation:  An VV, Sivakumar BS, Phan K, Trantalis J. A systematic review and meta-analysis of clinical and patient-reported outcomes following two procedures for recurrent traumatic anterior instability of the shoulder: Latarjet procedure vs. Bankart repair. J Shoulder Elbow Surg. 2016;25(5):853-863. CLINICAL QUESTION:   Are clinical and patient-reported outcomes different between the Latarjet and Bankart repair stabilization procedures when performed for recurrent traumatic anterior shoulder instability? DATA SOURCES:   Ovid MEDLINE, PubMed, Cochrane databases, American College of Physicians Journal Club, and Database of Abstracts of Review of Effectiveness were searched up to June 2015...
January 19, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29350537/cartilage-morphological-and-histological-findings-after-reconstruction-of-the-glenoid-with-an-iliac-crest-bone-graft
#17
Alexander Auffarth, Herbert Resch, Nicholas Matis, Martin Hudelmaier, Wolfgang Wirth, Rosemarie Forstner, Daniel Neureiter, Andreas Traweger, Philipp Moroder
BACKGROUND: The J-bone graft is presumably representative of iliac crest bone grafts in general and allows anatomic glenoid reconstruction in cases of bone defects due to recurrent traumatic anterior shoulder dislocations. As a side effect, these grafts have been observed to be covered by some soft, cartilage-like tissue when arthroscopy has been indicated after such procedures. PURPOSE: To evaluate the soft tissue covering of J-bone grafts by use of magnetic resonance imaging (MRI) and histological analysis...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29350375/neurological-recovery-after-traumatic-cauda-equina-syndrome-due-to-glass-fragments-an-unusual-case
#18
Mehmet Şenoğlu, Ali Karadağ, Çağlar Türk, Füsun Demirçivi Özer
Penetrating spinal injuries with foreign bodies are exceedingly rare. To date, pathological problems due to glass fragments in the spinal canal have rarely been reported. In this report, the case presenting with a back laceration, leg pain, and leg weakness was found to have glass frag-ments in the spinal canal at the L2-L3 level by lumbar computed tomography and magnetic resonance imaging. After L2 total laminectomy and retrieval of the glass fragments, the dura was re-paired. The patient was discharged from the hospital after complete neurological recovery...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350373/pediatric-dural-venous-sinus-thrombosis-following-closed-head-injury-an-easily-overlooked-diagnosis-with-devastating-consequences
#19
Joe M Das, Rashmi Sapkota, Binjura Shrestha
Dural venous sinus thrombosis (DVST) is an uncommon finding after traumatic brain injury. The diagnosis can often be initially missed, particularly if not associated with an overlying fracture. Pediatric DVST following closed head injury and without an overlying fracture is very rare, with only 20 cases reported in the literature to date. Here we present the case of a 19-month-old boy who presented with a history of trivial fall and an episode of fever. On presentation, the pediatric Glasgow Coma Scale (pGCS) score was E3V4M6, and initial brain computed tomography (CT) was normal...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350368/clinical-features-diagnosis-and-treatment-of-traumatic-pulmonary-pseudocysts
#20
Seray Hazer, Umut Perçem Orhan Söylemez
BACKGROUND: Traumatic pulmonary pseudocysts (TPP) are rare complications of blunt chest trauma. The aim of this study is to increase the understanding of this rare entity with imaging and clinical parameters for preventing complications and determining the correct treatment approach by observing 15 cases. METHODS: We retrospectively reviewed the medical data and thoracic computed tomography scans of 185 patients who underwent examinations in our department after chest trauma between July 2014 and December 2015...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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