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https://www.readbyqxmd.com/read/29453520/evaluation-of-a-comprehensive-oral-health-services-program-in-school-based-health-centers
#1
Tara Trudnak Fowler, Gregory Matthews, Cydny Black, Hendi Crosby Kowal, Pamella Vodicka, Elizabeth Edgerton
Objectives In 2011, the Maternal and Child Health Bureau, within the Health Resources and Services Administration, awarded a 4-year grant to increase access to and assure the delivery of quality oral health preventive and restorative services to children. The grant was awarded to organizations serving high-need communities through school-based health centers (SBHCs). This article describes an independent evaluation investigating program efficacy, integration, and sustainability. Methods Program process and outcomes data were gathered from interim and final reports...
February 16, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29418058/evolutionary-conservation-of-the-allosteric-activation-of-factor-viia-by-tissue-factor-in-lamprey
#2
D L Beeler, W C Aird, M A Grant
BACKGROUND: Previous studies have provided insight into the molecular basis of human tissue factor (TF) activation of activated factor VII (FVIIa). TF-induced allosteric networks of FVIIa activation have been rationalized through analysis of the dynamic changes and residue connectivities in the human soluble TF (sTF)/FVIIa complex structure during molecular dynamics (MD) simulation. Evolutionary conservation of the molecular mechanisms for TF-induced allosteric FVIIa activation between human and extant vertebrate jawless fish (lamprey), where blood coagulation emerged more than 500 million years ago, is unknown and of considerable interest...
February 8, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29398453/updated-molecular-testing-guideline-for-the-selection-of-lung-cancer-patients-for-treatment-with-targeted-tyrosine-kinase-inhibitors-guideline-from-the-college-of-american-pathologists-the-international-association-for-the-study-of-lung-cancer-and-the-association
#3
Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, Murry W Wynes, Yasushi Yatabe
CONTEXT: In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology to set standards for the molecular analysis of lung cancers to guide treatment decisions with targeted inhibitors. New evidence has prompted an evaluation of additional laboratory technologies, targetable genes, patient populations, and tumor types for testing. OBJECTIVE: To systematically review and update the 2013 guideline to affirm its validity; to assess the evidence of new genetic discoveries, technologies, and therapies; and to issue an evidence-based update...
January 23, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29397045/an-experiment-in-using-open-text-comments-from-the-australian-rural-mental-health-study-on-health-service-priorities
#4
Jane Rich, Tonelle Handley, Kerry Inder, David Perkins
INTRODUCTION: Conducting research in rural and remote areas is compounded by challenges associated with accessing relatively small populations spread over large geographical areas. Open-ended questions provided in a postal survey format are an advantageous way of including rural and remote residents in research studies. This method means that it is possible to ask for in-depth perspectives, from a large sample, in a relatively resource-efficient way. Such questions are frequently included in population-based surveys; however, they are rarely analysed...
February 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29396253/updated-molecular-testing-guideline-for-the%C3%A2-selection-of-lung-cancer-patients-for-treatment-with-targeted-tyrosine-kinase-inhibitors-guideline-from-the-college-of-american-pathologists-the%C3%A2-international-association-for-the-study-of-lung-cancer-and-the%C3%A2-association
#5
Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, Murry W Wynes, Yasushi Yatabe
CONTEXT: In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology to set standards for the molecular analysis of lung cancers to guide treatment decisions with targeted inhibitors. New evidence has prompted an evaluation of additional laboratory technologies, targetable genes, patient populations, and tumor types for testing. OBJECTIVE: To systematically review and update the 2013 guideline to affirm its validity; to assess the evidence of new genetic discoveries, technologies, and therapies; and to issue an evidence-based update...
January 23, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29395583/rotational-pedicle-myocutaneous-forearm-fillet-flap-used-to-fill-forequarter-amputation-defect-indications-and-uses
#6
REVIEW
Sagar A Shah, Wendy H Wong, Dhaval Adhvaryu
A full-thickness fourth-degree burn to a large area of the upper extremity may require a forequarter amputation. Whereas our case describes a burn injury, forequarter amputations may more commonly be done in oncological surgery. In addition to the challenge of providing well-vascularized tissue coverage, the burn patient may also pose the complication of respiratory compromise in a systemically ill person. Fillet flaps have often been utilized as "spare part" reconstruction. Although previous forequarter amputations have been covered with free myocutanous forearm fillet flaps, we devised a rotational pedicle myocutaneous forearm fillet flap that might be less complex than a microvascular reconstruction...
January 25, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29383415/autologous-fibroblast-seeded-amnion-for-reconstruction-of-neo-vagina-in-male-to-female-reassignment-surgery
#7
Kamal Seyed-Forootan, Hamid Karimi, Nazilla-Sadat Seyed-Forootan
BACKGROUND: Plastic surgeons have used several methods for the construction of neo-vaginas, including the utilization of penile skin, free skin grafts, small bowel or recto-sigmoid grafts, an amnion graft, and cultured cells. PURPOSE: The aim of this study is to compare the results of amnion grafts with amnion seeded with autograft fibroblasts. MATERIALS AND METHODS: Over 8 years, we compared the results of 24 male-to-female transsexual patients retrospectively based on their complications and levels of satisfaction...
January 30, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29372268/outcomes-of-fat-augmented-latissimus-dorsi-fald-flap-versus-implant-based-latissimus-dorsi-flap-for-delayed-post-radiation-breast-reconstruction
#8
Efterpi C Demiri, Dimitrios D Dionyssiou, Antonios Tsimponis, Christina-Olga Goula, Leonidas C Pavlidis, Georgia-Alexandra Spyropoulou
BACKGROUND: Although free abdominal flaps constitute the gold standard in post-radiation delayed breast reconstruction, latissimus dorsi-based methods offer alternative reconstructive options. This retrospective study aims to compare outcomes of delayed breast reconstruction using the fat-augmented latissimus dorsi (FALD) autologous reconstruction and the latissimus dorsi-plus-implant reconstruction in irradiated women. METHODS: We reviewed the files of 47 post-mastectomy irradiated patients (aged 29-73 years), who underwent delayed latissimus dorsi-based breast reconstruction between 2010 and 2016...
January 25, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29371084/instantaneous-wave-free-ratio-as-an-alternative-to-fractional-flow-reserve-in-assessment-of-moderate-coronary-stenoses-a-meta-analysis-of-diagnostic-accuracy-studies
#9
Rohit Maini, John Moscona, Paul Katigbak, Camilo Fernandez, Gursukhmandeep Sidhu, Qusai Saleh, Anand Irimpen, Rohan Samson, Thierry LeJemtel
BACKGROUND/PURPOSE: Fractional flow reserve (FFR) remains underutilized due to practical concerns related to the need for hyperemic agents. These concerns have prompted the study of instantaneous wave-free ratio (iFR), a vasodilator-free index of coronary stenosis. Non-inferior cardiovascular outcomes have been demonstrated in two recent randomized clinic trials. We performed this meta-analysis to provide a necessary update of the diagnostic accuracy of iFR referenced to FFR based on the addition of eight more recent studies and 3727 more lesions...
December 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29356072/flash-forward-a-review-of-flash-glucose-monitoring
#10
REVIEW
L Leelarathna, E G Wilmot
The FreeStyle Libre flash glucose monitor became available on prescription (subject to local health authority approval) in all four nations of the UK from November 2017, a watershed moment in the history of diabetes care. Calibration free, the FreeStyle Libre is a disc worn on the arm for 14 days which is designed largely to replace the recommended 4-10 painful finger-stick blood glucose tests required each day for the self-management of diabetes. This review discusses clinical data from randomized and observational studies, considers device accuracy metrics and deliberates its popularity and the potential challenges that this new device brings to diabetes care in the UK...
January 22, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29355391/updated-molecular-testing-guideline-for-the-selection-of-lung-cancer-patients-for-treatment-with-targeted-tyrosine-kinase-inhibitors-guideline-from-the-college-of-american-pathologists-the-international-association-for-the-study-of-lung-cancer-and-the-association
#11
Neal I Lindeman, Philip T Cagle, Dara L Aisner, Maria E Arcila, Mary Beth Beasley, Eric Bernicker, Carol Colasacco, Sanja Dacic, Fred R Hirsch, Keith Kerr, David J Kwiatkowski, Marc Ladanyi, Jan A Nowak, Lynette Sholl, Robyn Temple-Smolkin, Benjamin Solomon, Lesley H Souter, Erik Thunnissen, Ming S Tsao, Christina B Ventura, Murry W Wynes, Yasushi Yatabe
CONTEXT: - In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology to set standards for the molecular analysis of lung cancers to guide treatment decisions with targeted inhibitors. New evidence has prompted an evaluation of additional laboratory technologies, targetable genes, patient populations, and tumor types for testing. OBJECTIVE: - To systematically review and update the 2013 guideline to affirm its validity; to assess the evidence of new genetic discoveries, technologies, and therapies; and to issue an evidence-based update...
January 22, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29342158/real-time-community-detection-in-full-social-networks-on-a-laptop
#12
Benjamin Paul Chamberlain, Josh Levy-Kramer, Clive Humby, Marc Peter Deisenroth
For a broad range of research and practical applications it is important to understand the allegiances, communities and structure of key players in society. One promising direction towards extracting this information is to exploit the rich relational data in digital social networks (the social graph). As global social networks (e.g., Facebook and Twitter) are very large, most approaches make use of distributed computing systems for this purpose. Distributing graph processing requires solving many difficult engineering problems, which has lead some researchers to look at single-machine solutions that are faster and easier to maintain...
2018: PloS One
https://www.readbyqxmd.com/read/29320595/safety-and-efficacy-of-a-non-invasive-1060-nm-diode-laser-for-fat-reduction-of-the-abdomen
#13
Lawrence S Bass, Sean T Doherty
BACKGROUND: Changes in temperature are known to produce apoptosis in adipocytes. This study examines the use of a non-invasive treatment that applies 1060 nm laser energy transcutaneously to hyperthermically induce disruption of fat cells in the abdomen. METHODS: Thirty-five subjects received application of 1060 nm laser on the abdomen for fat reduction. Ultrasound images and high-resolution two-dimensional photography were recorded at baseline, 6 weeks, and 12 weeks post treatment...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29310355/revision-surgery-for-lumbar-hemivertebra-in-a-7-year-old-child-with-10-year-follow-up-a-case-report-a-care-compliant-article
#14
Xuhong Xue, Sheng Zhao
RATIONALE: Hemivertebrae, which are the most frequent cause of congenital scoliosis, pose a challenge in terms of prognosis and therapy. The current gold standard treatment congenital scoliosis due to a lumbar and thoracic hemivertebra would be hemivertebra resection and short level posterior spinal fusion. Paucity literatures are reported for the treatment of hemivertebra by convex fusion with posterior hemivertebra excision. PATIENT CONCERNS: The patient was first noticed to have a spinal problem at 7 years of age...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299907/self-assembled-layering-of-magnetic-nanoparticles-in-a-ferrofluid-at-silicon-surfaces
#15
Katharina Theis-Broehl, Erika C Vreeland, Andrew Gomez, Dale L Huber, Apurve Saini, Max Wolff, Brian Maranville, Erik Brok, Kathryn L Krycka, Joseph A Dura, Julie A Borchers
This article describes the 3D self-assembly of monodisperse colloidal magnetite nanoparticles from a dilute water-based ferrouid onto a silicon surface and the dependence of the resultant magnetic structure with applied field. The nanoparticles assemble into close-packed layers at the surface followed by more loosely-packed ones. The magnetic field-dependent magnetization of the individual nanoparticle layers depends on both the rotational freedom of the layer and the magnetization of the adjacent layers. For layers in which the nanoparticles are more free to rotate, the easy axis of the nanoparticle can readily orient along the field direction...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29279292/metrix-matrix-a-cloud-based-system-for%C3%A2-tracking-non-relative-value-unit-value-added-work-metrics
#16
Mark D Kovacs, Douglas H Sheafor, Paul G Thacker, Andrew D Hardie, Philip Costello
PURPOSE: In the era of value-based medicine, it will become increasingly important for radiologists to provide metrics that demonstrate their value beyond clinical productivity. In this article the authors describe their institution's development of an easy-to-use system for tracking value-added but non-relative value unit (RVU)-based activities. METHODS: Metrix Matrix is an efficient cloud-based system for tracking value-added work. A password-protected home page contains links to web-based forms created using Google Forms, with collected data populating Google Sheets spreadsheets...
December 23, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29243293/the-association-between-celiac-disease-and-periodontitis-results-from-nhanes-2009-2012
#17
Thomas Spinell, Francesco DeMayo, Matthew Cato, Ashley Thai, Eva J Helmerhorst, Peter H R Green, Benjamin Lebwohl, Ryan T Demmer
AIM: To investigate whether celiac disease (CD) was associated with periodontitis among a nationally representative sample of U.S. adults. MATERIALS AND METHODS: The National Health and Nutrition Examination Survey (NHANES) 2009-2012 enrolled 6,661 subjects with full-mouth periodontal examination and serological testing for anti-tissue transglutaminase (tTg) and anti-endomysial (EMA) antibodies. CD was defined as i) self-reported physician diagnosis while on a gluten-free diet; ii) or tTg levels>10...
December 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29240734/transient-expression-of-human-antibodies-in-mammalian-cells
#18
Rodrigo Vazquez-Lombardi, Damien Nevoltris, Ansha Luthra, Peter Schofield, Carsten Zimmermann, Daniel Christ
Recombinant expression of antibody molecules in mammalian cells offers important advantages over traditionally utilized bacterial expression, including glycosylation required for antibody functionality and markedly reduced levels of endotoxin contamination. Advances in transient mammalian expression systems enable high yields (>100 mg/liter) that now allow for effective recombinant antibody production at a reasonable cost. Here, we provide step-by-step protocols for the design and recombinant expression of full-length IgG antibodies and antibody-derived constructs (including Fab, Fc-fusions and bispecifics) in mammalian cells...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29240284/extracellular-matrix-stromal-vascular-fraction-gel-conditioned-medium-accelerates-wound-healing-in-a-murine-model
#19
Chengliang Deng, Yunfan He, Jingwei Feng, Ziqing Dong, Yao Yao, Hsiaopei Mok, Maohui Lin, Lu Feng
Conditioned medium (CM) is a new treatment modality in regenerative medicine and has shown a successful outcome in wound healing. We recently introduced extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel), an adipose-derived stem cell and adipose native extracellular matrix-enriched product for cytotherapy. This study aimed to evaluate the effect of CM from ECM/SVF-gel (Gel-CM) on wound healing compared with the conventional CM from adipose tissue (Adi-CM) and stem cell (SVF-CM). In vitro wound healing effect of three CMs on keratinocytes and fibroblasts was evaluated in terms of proliferation property, migratory property, and extracellular matrix production...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29229803/stokes-drift
#20
REVIEW
T S van den Bremer, Ø Breivik
During its periodic motion, a particle floating at the free surface of a water wave experiences a net drift velocity in the direction of wave propagation, known as the Stokes drift (Stokes 1847 Trans. Camb. Philos. Soc.8, 441-455). More generally, the Stokes drift velocity is the difference between the average Lagrangian flow velocity of a fluid parcel and the average Eulerian flow velocity of the fluid. This paper reviews progress in fundamental and applied research on the induced mean flow associated with surface gravity waves since the first description of the Stokes drift, now 170 years ago...
January 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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