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https://www.readbyqxmd.com/read/29026957/autologous-buccal-micro-mucosa-free-graft-combined-with-posterior-scrotal-flap-transfer-for-vaginoplasty-in-male-to-female-transsexuals-a-pilot-study
#1
Shu-Yi Wei, Feng-Yong Li, Qiang Li, Sen-Kai Li, Chuan-De Zhou, Yu Zhou, Yu-Jiao Cao, Si-Ya Zhang, Yang Zhao
BACKGROUND: The inverted peno-scrotal flap method is considered the standard method of vaginoplasty in male-to-female genital reassignment surgery. Though with numerous advantages, the method has its limitations regarding skin texture, lack of inherent lubrication, and that the tissues for creating the labia depend on the amount of tissues remaining after vaginoplasty. Our purpose was to describe the procedure and outcome of vaginoplasty applying a new technique: autologous buccal micro-mucosa free graft combined with posterior scrotal flap transfer, which could solve some of the problems the previous methods had...
October 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28986983/enzymatic-synthesis-of-chiral-amino-alcohols-by-coupling-transketolase-and-transaminase-catalyzed-reactions-in-a-cascading-continuous-flow-microreactor-system
#2
Pia Gruber, Filipe Carvalho, Marco P C Marques, Brian O'Sullivan, Fabiana Subrizi, Dragana Dobrijevic, John Ward, Helen C Hailes, Pedro Fernandes, Roland Wohlgemuth, Frank Baganz, Nicolas Szita
Rapid biocatalytic process development and intensification continues to be challenging with currently available methods. Chiral amino-alcohols are of particular interest as they represent key industrial synthons for the production of complex molecules and optically pure pharmaceuticals. (2S,3R)-2-amino-1,3,4-butanetriol (ABT), a building block for the synthesis of protease inhibitors and detoxifying agents, can be synthesized from simple, non-chiral starting materials, by coupling a transketolase- and a transaminase-catalyzed reaction...
October 7, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28971474/survival-from-tumours-of-the-central-nervous-system-in-danish-children-is-survival-related-to-family-circumstances
#3
Friederike Erdmann, Jeanette Falck Winther, Susanne Oksbjerg Dalton, Hajo Zeeb, Anja Krøyer, Andrea Bautz, Kjeld Schmiegelow, Joachim Schüz
Little is known about social inequalities in childhood cancer survival. We investigated the impact of family circumstances on survival from paediatric central nervous system (CNS) tumours in a nationwide, register-based cohort of Danish children. All children born between 1973 and 2006 and diagnosed with a CNS tumour before the age of 20 years (N=1,261) were followed until 10 years from diagnosis. Using Cox proportional hazards models, the impact of various family characteristics on overall survival was estimated...
October 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28960567/hepatitis-c-in-a-new-therapeutic-era-recontextualising-the-lived-experience
#4
David Whiteley, Anne Whittaker, Lawrie Elliott, Sarah Cunningham-Burley
AIMS AND OBJECTIVES: To explore the experience of adults living with hepatitis C in a new era of interferon-free treatment. BACKGROUND: Hepatitis C is a leading cause of morbidity and mortality worldwide, posing a significant challenge to global public health. Historically, the treatment of hepatitis C was poorly efficacious and highly demanding, however, more effective and tolerable therapies have become available in high-income nations in recent years. This is the first study to explore how these significant developments in the treatment of hepatitis C may have influenced the experience of those living with the virus, and their understanding of the disease...
September 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28941031/ozone-induced-stomatal-sluggishness-changes-stomatal-parameters-of-jarvis-type-model-in-white-birch-and-deciduous-oak
#5
Yasutomo Hoshika, Makoto Watanabe, Elisa Carrari, Elena Paoletti, Takayoshi Koike
Stomatal ozone flux is closely related to ozone injury to plants. Jarvis-type multiplicative model has been recommended for estimating stomatal ozone flux in forest trees. Ozone may change stomatal conductance by both stomatal closure and less efficient stomatal control (stomatal sluggishness). However, current Jarvis-type models did not account for these ozone effects on stomatal conductance in forest trees. We thus examined seasonal course of stomatal conductance in two common deciduous tree species native to northern Japan (white birch: Betula platyphylla var...
September 21, 2017: Plant Biology
https://www.readbyqxmd.com/read/28932354/cardiovascular-involvement-in-celiac-disease
#6
REVIEW
Edward J Ciaccio, Suzanne K Lewis, Angelo B Biviano, Vivek Iyer, Hasan Garan, Peter H Green
Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#7
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28887827/a-universal-parameterized-gradient-based-method-for-photon-beam-field-size-determination
#8
Sharon Lebron, Guanghua Yan, Jonathan Li, Bo Lu, Chihray Liu
PURPOSE: To propose a universal, parameterized gradient-based method (PGM) for radiation field size determination. METHODS: The PGM locates the beam profile's edge by parameterizing its penumbra region with a modified sigmoid function where the inflection point can be determined in a closed form. The parametrization was validated with filter-flattened (FF), flattening-filter-free (FFF) and wedged profiles measured on two Elekta linac models (Synergy and Versa HD)...
September 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28885307/the-treatment-of-paraprotein-related-kidney-disease
#9
Colin A Hutchison, Fei Xiong, Peter Mollee
PURPOSE OF REVIEW: Myeloma kidney and amyloid light-chain (AL) amyloidosis remain the principal kidney complications of paraproteins. In this review, we update readers to many of the recent advances which have occurred in the care and outcomes for patients with these presentations. RECENT FINDINGS: Myeloma kidney has historically caused a severe acute kidney injury with very poor outcomes. The combination of new diagnostic techniques, enabling a rapid diagnosis and novel chemotherapy agents has transformed these poor outcomes for the better...
September 6, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28854861/beyond-the-clinic-eluding-a-medical-diagnosis-of-anorexia-through-narrative
#10
Merav Shohet
The persistence and recurrence of anorexia nervosa poses a clinical challenge, and provides support for critiques of oppressive and injurious facets of society inscribed on women's bodies. This essay illustrates how a phenomenological, linguistic anthropological approach fruitfully traverses clinical and cultural perspectives by directing attention beyond the embodied experience of patients diagnosed with anorexia nervosa to those who are not clinically diagnosed. Extending a model of illness and recovery as entailing sufferers' emplotting of past, present, and imagined future selves, I argue that women's accounts of their experiences do not simply reflect lived reality, but actually propel health-relevant states of being by enlivening and creating these realities in the process of their telling...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/28851401/knowledge-sharing-in-global-health-research-the-impact-uptake-and-cost-of-open-access-to-scholarly-literature
#11
Elise Smith, Stefanie Haustein, Philippe Mongeon, Fei Shu, Valéry Ridde, Vincent Larivière
BACKGROUND: In 1982, the Annals of Virology published a paper showing how Liberia has a highly endemic potential of Ebola warning health authorities of the risk for potential outbreaks; this journal is only available by subscription. Limiting the accessibility of such knowledge may have reduced information propagation toward public health actors who were indeed surprised by and unprepared for the 2014 epidemic. Open access (OA) publication can allow for increased access to global health research (GHR)...
August 29, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28842752/sexuality-among-women-treated-for-breast-cancer-a-survey-of-three-surgical-procedures
#12
Ana Olivia Cortés-Flores, Adriana Vargas-Meza, Gilberto Morgan-Villela, Jorge Jiménez-Tornero, Carlos José Zuloaga-Fernández Del Valle, Manuel Solano-Genesta, Roberto Carlos Miranda-Ackerman, Iztel Vázquez-Reyna, Luis Alberto García-González, Guillermo Alonso Cervantes-Cardona, Gabino Cervantes-Guevara, Clotilde Fuentes-Orozco, Alejandro González-Ojeda
BACKGROUND: The quality of life of Mexican patients with breast cancer has been studied, but female sexual function has only been explored superficially. The Female Sexual Function Index (FSFI) questionnaire has been validated as a tool to measure sexual function among women with cancer. However, no study in Mexico has been published. PURPOSE: To evaluate and compare female sexuality of breast cancer survivors treated with three surgical procedures. MATERIALS AND METHODS: This is a cross-sectional questionnaire survey applied in patients without active disease and free of any oncologic treatment who underwent conservative mastectomy, and mastectomy with and without reconstruction...
August 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28834582/controlled-crosslinking-of-trimethylolpropane-trimethacrylate-for-preparation-of-organic-monolithic-columns-for-capillary-liquid-chromatography
#13
Mariana R Gama, Pankaj Aggarwal, Milton L Lee, Carla B G Bottoli
Organic monolithic columns based on single crosslinking of trimethylolpropane trimethacrylate (TRIM) monomer were prepared in a single step by living/controlled free-radical polymerization. Full optimization of the preparation, such as using different percentages of TRIM and different amounts of radical promoter as well as various porogen solvents were explored. The resulting monolithic columns were characterized by scanning electronic microscopy and nitrogen sorption for structure morphology studies and surface area measurements, respectively...
August 23, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28832985/aggressive-digital-papillary-adenocarcinoma-treatment-with-mohs-micrographic-surgery-and-an-update-of-the-literature
#14
Rebecca W Knackstedt, Thomas J Knackstedt, Alyssa B Findley, Melissa Piliang, Nathaniel J Jellinek, Steven L Bernard, Allison Vidimos
BACKGROUND: Aggressive digital papillary adenocarcinoma (ADPA) is a rare adenocarcinoma of the sweat glands. AIMS: We wish to report the treatment of two cases of ADPA with Mohs micrographic surgery and review the presentation, management, and prognosis of this rare malignancy. MATERIALS & METHODS: Cases of ADPA were identified from recent surgery logs. Demographic, tumor, and treatment characteristics were extracted. A PubMed database search for English language full-text articles of aggressive digital papillary adenocarcinoma was performed, and relevant articles were summarized...
August 21, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28805296/basidiomycete-specific-pscamkl1-encoding-a-camk-like-protein-kinase-is-required-for-full-virulence-of-puccinia-striiformis-f-sp-tritici
#15
Min Jiao, Dan Yu, Chenglong Tan, Jia Guo, Dingyun Lan, Ershang Han, Tuo Qi, Ralf Thomas Voegele, Zhensheng Kang, Jun Guo
Calcium/calmodulin-dependent kinases (CaMKs) are Ser/Thr protein kinases (PKs) that respond to changes in cytosolic free Ca(2+) and play diverse roles in eukaryotes. In fungi, CAMKs are generally classified into four families CAMK1, CAMKL, RAD53, and CAMK-Unique. Among these, CAMKL constitutes the largest family. In some fungal plant pathogens members of the CaMKL family have been shown to be responsible for pathogenesis. However, little is known about their role(s) in rust fungi. In this study, we functionally characterized a novel PK gene, PsCaMKL1, from Puccinia striiformis f...
August 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28753684/erratum-unexpected-serious-cardiac-arrhythmias-in-the-setting-of-loperamide-abuse
#16
Somwail Rasla, Parag Parikh, Peter Hoffmeister, Amy St Amand, Marina K Garas, Amr El Meligy, Taro Minami, Nishant R Shah
Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea. When ingested in excessive doses, loperamide can penetrate the blood-brain barrier and is reported to produce euphoria, central nervous system and respiratory depression, and cardiotoxicity. There is an emerging trend in its use among drug abusers for its euphoric effects or for self-treatment of opioid withdrawal. We report a case of ventricular dysrhythmias associated with loperamide abuse in a 28-year-old man who substituted loperamide for the opioids that he used to abuse...
August 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28752641/influenza-virus-like-particles-harboring-h9n2-ha-and-na-proteins-induce-a-protective-immune-response-in-chicken
#17
Xin Li, Houbin Ju, Jian Liu, Dequan Yang, Xinyong Qi, Xianchao Yang, Yafeng Qiu, Jie Zheng, Feifei Ge, Jinping Zhou
BACKGROUND: Avian influenza viruses represent a growing threat of an influenza pandemic. The co-circulation of multiple H9N2 genotypes over the past decade has been replaced by one predominant genotype-G57 genotype, which displays a changed antigenicity and improved adaptability in chickens. Effective H9N2 subtype avian influenza virus vaccines for poultry are urgently needed. OBJECTIVE: In this study, we constructed H9N2 subtype avian influenza virus-like particle (VLP) and evaluated its protective efficacy in specific pathogen-free (SPF) chickens to lay the foundation for developing an effective vaccine against influenza viruses...
July 28, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28740443/approaches-to-teach-evidence-based-practice-among-health-professionals-an-overview-of-the-existing-evidence
#18
REVIEW
Athina E Patelarou, Konstantinos G Kyriakoulis, Aliki A Stamou, Aggelos Laliotis, Dimitra Sifaki-Pistolla, Michail Matalliotakis, Emmanuel Prokopakis, Evridiki Patelarou
Health care professionals' adoption of evidence-based practice (EBP) remains limited, although most health care professionals are familiar with EBP and believe in its value. This systematic review aimed to bring together the best methods used to teach EBP to health professionals. The authors conducted a systematic search for the period 2005-2015 (an update of the search took place in October 2016) using PubMed interface (Medline). MeSH terms as well as free-text keywords were used. Studies were analyzed and evaluated by title and abstract...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28737562/dynamic-cleft-maxillary-orthopedics-and-periosteoplasty-25-patients-25-years
#19
Frederick N Lukash, Lauren B Shikowitz-Behr, Michael Schwartz, Frank Tuminelli
In 1985 this cleft team, dissatisfied with the treatment and results from cleft lip and palate repair, began a longitudinal long-term study using dynamic maxillary orthopedics and periosteoplasty as was originally described by Drs Millard and Latham. All cases were carefully documented through adolescence, including clinical assessments, orthodontic, radiographic, and cephalometric analyses. In 1998, in this journal, we published our data on 35 complete unilateral and 10 complete bilateral cleft patients. At that time facial growth was following normal cephalometric patterns...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28731832/effects-of-cervical-high-velocity-low-amplitude-techniques-on-range-of-motion-strength-performance-and-cardiovascular-outcomes-a-review
#20
Xabier Galindez-Ibarbengoetxea, Igor Setuain, Lars L Andersen, Robinson Ramírez-Velez, Miriam González-Izal, Andoni Jauregi, Mikel Izquierdo
BACKGROUND: Cervical high-velocity low-amplitude (HVLA) manipulation technique is among the oldest and most frequently used chiropractic manual therapy, but the physiologic and biomechanics effects were not completely clear. OBJECTIVE: This review aims to describe the effects of cervical HVLA manipulation techniques on range of motion, strength, and cardiovascular performance. METHODS/DESIGN: A systematic search was conducted of the electronic databases from January 2000 to August 2016: PubMed (n = 131), ScienceDirect (n = 101), Scopus (n = 991), PEDro (n = 33), CINAHL (n = 884), and SciELO (n = 5)...
September 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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