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https://www.readbyqxmd.com/read/29243293/the-association-between-celiac-disease-and-periodontitis-results-from-nhanes-2009-2012
#1
Thomas Spinell, Francesco DeMayo, Matthew Cato, Ashley Thai, Eva J Helmerhorst, Peter H R Green, Benjamin Lebwohl, Ryan T Demmer
AIM: To investigate whether celiac disease (CD) was associated with periodontitis among a nationally representative sample of U.S. adults. MATERIALS AND METHODS: The National Health and Nutrition Examination Survey (NHANES) 2009-2012 enrolled 6,661 subjects with full-mouth periodontal examination and serological testing for anti-tissue transglutaminase (tTg) and anti-endomysial (EMA) antibodies. CD was defined as i) self-reported physician diagnosis while on a gluten-free diet; ii) or tTg levels>10...
December 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29240734/transient-expression-of-human-antibodies-in-mammalian-cells
#2
Rodrigo Vazquez-Lombardi, Damien Nevoltris, Ansha Luthra, Peter Schofield, Carsten Zimmermann, Daniel Christ
Recombinant expression of antibody molecules in mammalian cells offers important advantages over traditionally utilized bacterial expression, including glycosylation required for antibody functionality and markedly reduced levels of endotoxin contamination. Advances in transient mammalian expression systems enable high yields (>100 mg/liter) that now allow for effective recombinant antibody production at a reasonable cost. Here, we provide step-by-step protocols for the design and recombinant expression of full-length IgG antibodies and antibody-derived constructs (including Fab, Fc-fusions and bispecifics) in mammalian cells...
January 2018: Nature Protocols
https://www.readbyqxmd.com/read/29240284/extracellular-matrix-stromal-vascular-fraction-gel-conditioned-medium-accelerates-wound-healing-in-a-murine-model
#3
Chengliang Deng, Yunfan He, Jingwei Feng, Ziqing Dong, Yao Yao, Hsiaopei Mok, Maohui Lin, Lu Feng
Conditioned medium (CM) is a new treatment modality in regenerative medicine and has shown a successful outcome in wound healing. We recently introduced extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel), an adipose-derived stem cell and adipose native extracellular matrix-enriched product for cytotherapy. This study aimed to evaluate the effect of CM from ECM/SVF-gel (Gel-CM) on wound healing compared with the conventional CM from adipose tissue (Adi-CM) and stem cell (SVF-CM). In vitro wound healing effect of three CMs on keratinocytes and fibroblasts was evaluated in terms of proliferation property, migratory property, and extracellular matrix production...
December 14, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29229803/stokes-drift
#4
REVIEW
T S van den Bremer, Ø Breivik
During its periodic motion, a particle floating at the free surface of a water wave experiences a net drift velocity in the direction of wave propagation, known as the Stokes drift (Stokes 1847 Trans. Camb. Philos. Soc.8, 441-455). More generally, the Stokes drift velocity is the difference between the average Lagrangian flow velocity of a fluid parcel and the average Eulerian flow velocity of the fluid. This paper reviews progress in fundamental and applied research on the induced mean flow associated with surface gravity waves since the first description of the Stokes drift, now 170 years ago...
January 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29216789/open-book-exams-a-potential-solution-to-the-full-curriculum
#5
Andrew Teodorczuk, James Fraser, Gary D Rogers
In this Personal View article, as curriculum designers, we consider whether there is a place for open book exams in Medical School curricula. Specifically, at a time when medical teachers complain about the difficulties of delivering a full curriculum, we propose that open book assessment approaches may help to free up the curriculum as learners become less reliant on memorizing facts. Moreover deeper learning of higher level outcomes can be achieved and more authentic assessment approaches undertaken. We also look at the recent literature and consider reasons, both for and against open book exams, at theoretical and practical levels...
December 7, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29215148/31-p-t2-s-of-phosphomonoesters-phosphodiesters-and-inorganic-phosphate-in-the-human-brain-at-7t
#6
Wybe J M van der Kemp, Dennis W J Klomp, Jannie P Wijnen
PURPOSE: To determine the phosphorus-31 T2 s of phosphomonoesters, phosphodiesters, and inorganic phosphate in the healthy human brain at 7T. METHODS: A 3D chemical shift imaging multi-echo sequence with composite block pulses for refocusing was used to measure one free induction decay (FID) and seven full echoes with an echo spacing of 45 ms on the brain of nine healthy volunteers (age range 22-45 years; average age 27 ± 8 years). Spectral fitting was used to determine the change in metabolic signal amplitude with echo time...
December 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29215139/a-novel-and-selective-nociceptin-receptor-nop-agonist-1-1-cis-4-isopropylcyclohexyl-piperidin-4-yl-1h-indol-2-yl-methanol-at-312-decreases-acquisition-of-ethanol-induced-conditioned-place-preference-in-mice
#7
Nurulain T Zaveri, Paul V Marquez, Michael E Meyer, Willma E Polgar, Abdul Hamid, Kabirullah Lutfy
BACKGROUND: Nociceptin/Orphanin FQ (N/OFQ), the endogenous peptide agonist for the opioid receptor-like (ORL1) receptor (also known as NOP or the nociceptin receptor), has been shown to block the acquisition and expression of ethanol-induced conditioned place preference (CPP). Here, we report the characterization of a novel small-molecule NOP ligand AT-312 (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol) in receptor binding and GTPγS functional assays in vitro...
December 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29209611/histological-grading-of-hepatocellular-carcinoma-a-systematic-review-of-literature
#8
Sebastiao N Martins-Filho, Caterina Paiva, Raymundo Soares Azevedo, Venancio Avancini Ferreira Alves
Background: Histological grading typically reflects the biological behavior of solid tumors, thus providing valuable prognostic information. This is also expected in hepatocellular carcinoma (HCC), although limited access to biopsy samples and a lack of standardization might hinder its full predictive value in this cancer. Objectives: In order to better understand the current practices of histological grading in HCC, we examined the latest publications addressing its impact on the outcome of patients following surgical treatment...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29197438/clinical-outcomes-of-comparing-soft-tissue-alternatives-to-free-gingival-graft-a-systematic-review-and-meta-analysis%C3%A2
#9
Irina F Dragan, Lucrezia Paterno Hotlzman, Nadeem Y Karimbux, Rebecca A Morin, Seyed Hossein Bassir
OBJECTIVES: This systematic review and meta-analysis aimed to compare clinical outcomes and width of keratinized tissue (KT) around teeth, following the soft tissue alter- natives and free gingival graft (FGG) procedures. The specific graft materials that were explored were extracellular matrix membrane, bilayer collagen membrane, living cellular construct, and acellular dermal matrix. METHODS: Four different databases were queried to identify human controlled clinical trials and randomized controlled clinical trials that fulfilled the eligibility criteria...
December 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29194596/truncated-isoform-vav3-1-is-highly-expressed-in-ovarian-cancer-stem-cells-and-clinically-relevant-in-predicting-prognosis-and-platinum-response
#10
Daniel Reimer, Maximilian Boesch, Dominik Wolf, Christian Marth, Sieghart Sopper, Jiri Hatina, Peter Altevogt, Walther Parson, Hubert Hackl, Alain G Zeimet
Vav3 is a key modulator of GTP-hydrolases of the Rho/Rac family, which are crucially involved in cell proliferation. Vav3 is alternatively spliced in full-length Vav3-alpha and N-terminal truncated Vav3.1 lacking its self-regulatory domains. The aim of this study was to estimate the clinical impact of Vav3 and all other Vav family members in ovarian cancer. Purification of a stem-cell like side-population (SP) from ovarian cancer cell lines was performed by flow cytometry/FACS. Differences in gene expression between SP and NSP were assessed by Gene Array analysis and confirmed by RT-PCR and immunoblot...
December 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29192015/the-european-medicines-agency-review-of-panobinostat-farydak-for-the-treatment-of-adult-patients-with-relapsed-and-or-refractory-multiple-myeloma
#11
REVIEW
Kyriaki Tzogani, Paula van Hennik, Ita Walsh, Pieter De Graeff, Annika Folin, Jan Sjöberg, Tomas Salmonson, Jonas Bergh, Edward Laane, Heinz Ludwig, Christian Gisselbrecht, Francesco Pignatti
On August 28, 2015, a marketing authorization valid through the European Union was issued for panobinostat, in combination with bortezomib and dexamethasone, for the treatment of adult patients with relapsed and/or refractory multiple myeloma who have received at least two prior regimens including bortezomib and an immunomodulatory agent (IMiD).Panobinostat is an orally available histone deacetylase (HDAC) inhibitor that inhibits the enzymatic activity of HDAC proteins at nanomolar concentrations. HDAC proteins catalyze the removal of acetyl groups from the lysine residues of histones and some nonhistone proteins...
November 30, 2017: Oncologist
https://www.readbyqxmd.com/read/29175135/a-systematic-review-of-near-infrared-spectroscopy-in-flap-monitoring-current-basic-and-clinical-evidence-and-prospects
#12
REVIEW
Yu Kagaya, Shimpei Miyamoto
BACKGROUND: Near-infrared spectroscopy (NIRS) has been reported to be a reliable non-invasive modality for free flap monitoring; however, the history of its application in flap monitoring is short, and there is no definite consensus regarding its use at present. OBJECTIVES: The aim of this review is to clarify the evidence related to post-operative flap monitoring using NIRS and examine its appropriateness and usability. MATERIALS AND METHODS: The PubMed and Web of Science databases were searched using the strings "flap monitoring AND near-infrared spectroscopy" and "flap monitoring AND tissue oxygen saturation," with a study period from inception to December 31, 2016...
November 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29168193/the-effects-of-long-term-varenicline-administration-on-ethanol-and-sucrose-seeking-and-self-administration-in-male-p-rats
#13
Cristine L Czachowski, Janice C Froehlich, Michael DeLory
BACKGROUND: Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA approved for treatment of smoking cessation and has been found to reduce alcohol craving in clinical populations. In rodents, varenicline decreases free-choice ethanol intake with somewhat mixed findings in operant paradigms that utilize a combined appetitive/consummatory response. METHODS: The present experiment utilized an operant paradigm that procedurally separates appetitive from consummatory responding and a "reward blocking" approach (i...
November 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29125628/genomics-based-non-invasive-prenatal-testing-for-detection-of-fetal-chromosomal-aneuploidy-in-pregnant-women
#14
REVIEW
Mylène Badeau, Carmen Lindsay, Jonatan Blais, Leon Nshimyumukiza, Yemisi Takwoingi, Sylvie Langlois, France Légaré, Yves Giguère, Alexis F Turgeon, William Witteman, François Rousseau
BACKGROUND: Common fetal aneuploidies include Down syndrome (trisomy 21 or T21), Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and 47,XYY syndrome (47,XYY). Prenatal screening for fetal aneuploidies is standard care in many countries, but current biochemical and ultrasound tests have high false negative and false positive rates. The discovery of fetal circulating cell-free DNA (ccfDNA) in maternal blood offers the potential for genomics-based non-invasive prenatal testing (gNIPT) as a more accurate screening method...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29124945/protecting-the-human-right-to-freedom-of-expression-in-international-law
#15
Emily Howie
Since its inclusion in Article 19 of the Universal Declaration of Human Rights, the right to freedom of opinion and expression has been protected in all of the relevant international human rights treaties. In international law, freedom to express opinions and ideas is considered essential at both an individual level, insofar as it contributes to the full development of a person, and being a foundation stone of democratic society. Free speech is a necessary precondition to the enjoyment of other rights, such as the right to vote, free assembly and freedom of association, and is essential to ensure press freedom...
November 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29114035/an-ultra-stable-single-chain-insulin-analog-resists-thermal-inactivation-and-exhibits-biological-signaling-duration-equivalent-to-the-native-protein
#16
Michael D Glidden, Khadijah Aldabbagh, Nelson B Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C Lawrence, Vivien C Yee, Faramarz Ismail-Beigi, Michael A Weiss
Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded by prolonged cellular signaling in vivo, complicating mealtime therapy and of unclear safety. We therefore sought an ultra-stable analog whose potency and duration of action on intravenous bolus injection in diabetic rats are indistinguishable from wild-type (WT) insulin. Here, we describe the structure, function and stability of such an analog: a 57-residue single-chain insulin (SCI) with multiple acidic substitutions...
November 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29106742/density-weighted-concentric-circle-trajectories-for-high-resolution-brain-magnetic-resonance-spectroscopic-imaging-at-7t
#17
Lukas Hingerl, Wolfgang Bogner, Philipp Moser, Michal Považan, Gilbert Hangel, Eva Heckova, Stephan Gruber, Siegfried Trattnig, Bernhard Strasser
PURPOSE: Full-slice magnetic resonance spectroscopic imaging at ≥7 T is especially vulnerable to lipid contaminations arising from regions close to the skull. This contamination can be mitigated by improving the point spread function via higher spatial resolution sampling and k-space filtering, but this prolongs scan times and reduces the signal-to-noise ratio (SNR) efficiency. Currently applied parallel imaging methods accelerate magnetic resonance spectroscopic imaging scans at 7T, but increase lipid artifacts and lower SNR-efficiency further...
November 6, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29105146/the-effect-of-the-gluten-free-diet-on-cardiovascular-risk-factors-in-patients-with-coeliac-disease-a-systematic-review
#18
M D E Potter, S C Brienesse, M M Walker, A Boyle, N J Talley
INTRODUCTION: A gluten free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result in micronutrient deficiencies, increased exposure to toxins such as arsenic, and an increased cardiovascular risk. This systematic review addresses the effect of the GFD on several modifiable cardiovascular risk factors...
November 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29101442/modifications-of-z-epicanthoplasty-combined-with-double-eyelid-blepharoplasty-in-asians
#19
Shun Wu, Ke Guo, Peng Xiao, Jiaming Sun
BACKGROUND: Epicanthoplasty combined with double-eyelid blepharoplasty is one of the most popular cosmetic procedures in Asians. However, the postoperative medial canthal scar is a concerned issue. Here the authors adopted some modifications of Z-epicanthoplasty to minimize the canthal scar. METHODS: Modifications of Z-epicanthoplasty were mainly in three aspects. First, supratarsal creases were created before epicanthoplasty to prevent the impact of tension variation on epicanthal incisions, caused by elevating and tightening of the upper eyelid skin...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29101436/anaplastic-large-cell-lymphoma-associated-with-breast-implants-a-case-report-of-a-transgender-female
#20
Matej Patzelt, Lucie Zarubova, Pavel Klener, Josef Barta, Kamila Benkova, Adrianna Brandejsova, Marek Trneny, Robert Gürlich, Andrej Sukop
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T cell lymphoma. BIA-ALCL is a disease of the fibrous capsule surrounding the implant and occurs in patients after both breast reconstruction and augmentation. More than 300 cases have been reported so far, including two in a transgender patient. Here we describe BIA-ALCL presented with a mass in a transgender patient and the first case of BIA-ALCL in the Czech Republic. In 2007, a 33-year-old transgender male to female underwent bilateral breast augmentation as a part of his transformation to female...
November 3, 2017: Aesthetic Plastic Surgery
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