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https://www.readbyqxmd.com/read/29663480/hepatocellular-carcinoma-associated-protein-td26-interacts-and-enhances-srebp1-activity-to-promote-tumor-cell-proliferation-and-growth
#1
Chenchen Wang, Ying Tong, Yankai Wen, Jie Cai, Han Guo, Lifeng Huang, Min Xu, Mingxuan Feng, Xiaosong Chen, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Increased lipogenesis has been reported to play a critical role in HCC progression. However, the underlying mechanism contributing to lipogenesis increase in HCC remains elusive. Here, we show that hepatocellular carcinoma-associated protein TD26 (TD26) was highly expressed in HCC tumor tissues compared to matched normal tissues. From the clinicopathologic analyses of two independent HCC cohorts, we demonstrate that TD26 expression was positively correlated with tumor size and was an independent predictor of overall survival (OS) and recurrence free survival (RFS) in HCC patients...
April 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29658143/which-very-elderly-diffuse-large-b-cell-lymphoma-patients-can-benefit-from-curative-treatment-a-multicenter-retrospective-analysis-by-the-spanish-geltamo-group
#2
Emilia Pardal, Eva Díez Baeza, Queralt Salas, Tomás García, Juan M Sancho, Encarna Monzón, José M Moraleda, Raúl Córdoba, Fátima de la Cruz, José A Queizán, María J Rodríguez, Belén Navarro, José A Hernández, Rosana Díez, María Vahi, María C Viguria, Miguel Canales, María J Peñarrubia, Tomás J González-López, Santiago Montes-Moreno, Eva González-Barca, Dolores Caballero, Alejandro Martín
The means of optimally managing very elderly patients with diffuse large B-cell lymphoma (DLBCL) has not been established. We retrospectively analyzed 252 patients aged 80-100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression-free survival (PFS) and overall survival (OS). 163 patients (63%) were treated with chemotherapy that included anthracyclines and/or rituximab, whereas 15% received no chemotherapeutic treatment...
April 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29650041/deep-learning-meets-ontologies-experiments-to-anchor-the-cardiovascular-disease-ontology-in-the-biomedical-literature
#3
Mercedes Arguello Casteleiro, George Demetriou, Warren Read, Maria Jesus Fernandez Prieto, Nava Maroto, Diego Maseda Fernandez, Goran Nenadic, Julie Klein, John Keane, Robert Stevens
BACKGROUND: Automatic identification of term variants or acceptable alternative free-text terms for gene and protein names from the millions of biomedical publications is a challenging task. Ontologies, such as the Cardiovascular Disease Ontology (CVDO), capture domain knowledge in a computational form and can provide context for gene/protein names as written in the literature. This study investigates: 1) if word embeddings from Deep Learning algorithms can provide a list of term variants for a given gene/protein of interest; and 2) if biological knowledge from the CVDO can improve such a list without modifying the word embeddings created...
April 12, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29649387/multi-omics-research-trends-in-sepsis-a-bibliometric-comparative-analysis-between-the-united-states-the-european-union-28-member-states-and-china
#4
Nikolaos Evangelatos, Kapaettu Satyamoorthy, Georgia Levidou, Pia Bauer, Helmut Brand, Christina Kouskouti, Hans Lehrach, Angela Brand
"-Omics" research is in transition with the recent rise of multi-omics technology platforms. Integration of "-omics" and multi-omics research is of high priority in sepsis, a heterogeneous syndrome that is widely recognized as a global health burden and a priority biomedical funding field. We report here an original study on bibliometric trends in the use of "-omics" technologies, and multi-omics approaches in particular, in sepsis research in three (supra)national settings, the United States, the European Union 28 Member States (EU-28), and China...
March 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29644533/systematic-review-of-clinical-outcomes-following-various-treatment-options-for-patients-with-extraabdominal-desmoid-tumors
#5
Kortnye Smith, Jayesh Desai, Smaro Lazarakis, David Gyorki
BACKGROUND: Desmoid tumors (DT) are rare clonal proliferations that arise from mesenchymal cells. These tumors do not metastasize but are locally aggressive, and their growth may lead to significant morbidity. Their clinical course is both variable and unpredictable; tumors may rapidly progress but in other instances remain stable or regress without intervention. AIMS: To examine current treatment of DT and assist with decision-making at time of presentation. METHODS: A literature search was conducted of MEDLINE and Cochrane databases for published studies (1995-July 2015) using the search terms fibromatosis aggressive, desmoid with drug therapy, radiation therapy, prevention and control, radiotherapy, surgery, and therapy...
April 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29628809/cytokine-involvement-in-biological-inflammation-related-to-degenerative-disorders-of-the-intervertebral-disk-a-narrative-review
#6
REVIEW
Christopher M De Geer
Objective: The purpose of this narrative literature review is to discuss the literature regarding the potential role that cytokines play in degenerative disk disease. Methods: The inclusion criteria were studies that used inflammatory mediators in advancing disk disease processes. Research studies were limited to the last 3 decades that had free full-text available online in English. Exclusion criteria were review articles and articles pertaining to temporomandibular joints and other joints of the body other than the intervertebral disk...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29603735/unexpected-instabilities-explain-batch-to-batch-variability-in-cell-free-protein-expression-systems
#7
Dominic J B Hunter, Akshay Bhumkar, Nichole Giles, Emma Sierecki, Yann Gambin
Cell-free methods of protein synthesis offer rapid access to expressed proteins. Though the amounts produced are generally only at a small scale, these are sufficient to perform protein-protein interaction assays and tests of enzymatic activity. As such they are valuable tools for the biochemistry and bioengineering community. However the most complex, eukaryotic cell-free systems are difficult to manufacture in house and can be prohibitively expensive to obtain from commercial sources. The Leishmania tarentolae system offers a relatively cheap alternative which is capable of producing difficult to express proteins, but which is simpler to produce in large scale...
March 31, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29601620/multi-center-double-blind-vehicle-controlled-clinical-trial-of-an-alpha-and-beta-defensin-containing-anti-aging-skin-care-regimen-with-clinical-histopathologic-immunohistochemical-photographic-and-ultrasound-evaluation
#8
Amy Taub, Vivian Bucay, Gregory Keller, Jay Williams, Darius Mehregan
BACKGROUND/OBJECTIVES: Anti-aging strategies utilizing stem cells are in the forefront. Alpha and beta defensins are natural immune peptides that have been shown to activate an LGR6-positive stem cell locus in the hair follicle, identified as the source of most new epidermal cells during acute wound healing. We investigated the ability of biomimetic alpha and beta defensin molecules, supplemented with supportive cosmetic ingredients, formulated into three skin care products, at improving the structure and function of aging skin...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29599391/dupuytren-treatment-effectiveness-trial-detect-a-protocol-for-prospective-randomised-controlled-outcome-assessor-blinded-three-armed-parallel-1-1-1-multicentre-trial-comparing-the-effectiveness-and-cost-of-collagenase-clostridium-histolyticum-percutaneous-needle
#9
Mikko P Räisänen, Teemu Karjalainen, Harry Göransson, Aleksi Reito, Hannu Kautiainen, Antti Malmivaara, Olli V Leppänen
INTRODUCTION: Dupuytren's contracture (DC) is a chronic fibroproliferative disorder of the palmar fascia which leads to flexion contracture in one or more fingers. There is no definitive cure for DC, and treatment aims at relieving symptoms by releasing the contracture using percutaneous or operative techniques. METHODS AND ANALYSIS: We planned a prospective, randomised, controlled, outcome assessor-blinded, three-armed parallel 1:1:1, multicentre trial comparing the effectiveness and cost of (1) collagenase clostridium histolyticum injection followed by limited fasciectomy in non-responsive cases, (2) percutaneous needle fasciotomy followed by limited fasciectomy in non-responsive cases and (3) primary limited fasciectomy during short-term and long-term follow-up for Tubiana I-III stages DC...
March 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29589494/intercalary-reconstruction-of-the-femur-after-tumour-resection
#10
D A Campanacci, F Totti, S Puccini, G Beltrami, G Scoccianti, L Delcroix, M Innocenti, R Capanna
Aims After intercalary resection of a bone tumour from the femur, reconstruction with a vascularized fibular graft (VFG) and massive allograft is considered a reliable method of treatment. However, little is known about the long-term outcome of this procedure. The aims of this study were to determine whether the morbidity of this procedure was comparable to that of other reconstructive techniques, if it was possible to achieve a satisfactory functional result, and whether biological reconstruction with a VFG and massive allograft could achieve a durable, long-lasting reconstruction...
March 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29577657/fast-uncertainty-quantification-of-activation-sequences-in-patient-specific-cardiac-electrophysiology-meeting-clinical-time-constraints
#11
A Quaglino, S Pezzuto, P-S Koutsourelakis, A Auricchio, R Krause
We present a fast, patient-specific methodology for uncertainty quantification in electrophysiology, aimed at meeting the time constraints of clinical practitioners. We focus on computing the statistics of the activation map, given the uncertainties associated with the conductivity tensor modeling the fibers orientation in the heart. We employ a fast parallel solution method implemented on a GPU for the eikonal approximation, in order to compute the activation map and to sample the random fiber field with correlation based on geodesic distances...
March 26, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29576434/surgical-versus-medical-treatment-of-drug-resistant-epilepsy-a-systematic-review-and-meta-analysis
#12
REVIEW
Jin-Tao Liu, Bei Liu, Hua Zhang
OBJECTIVE: Surgery and drug therapy are the two main treatments for refractory epilepsy. However, to date, there has not been an adequate comparison of the outcomes of these two treatments. This systematic review compared the overall outcome of surgery and medical treatment in patients with drug-resistant epilepsy. METHODS: Articles published in Embase, Medline, Pubmed, and the Cochrane library were searched from their inception until June 2016. RESULTS: Twenty of the eighty-one (24...
March 23, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29566435/anaemia-and-thyrotoxicosis-the-need-to-look-for-an-alternative-cause
#13
S Sehgal, J A U Tamatea, J V Conaglen, M S Elston
OBJECTIVES: Anaemia and thyrotoxicosis are both relatively common. It is unclear whether thyrotoxicosis results in anaemia in the absence of other causes. The aim of this study was to determine the prevalence and characteristics of anaemia in patients with thyrotoxicosis. DESIGN: A prospective cohort study of patients with thyrotoxicosis. PATIENTS: 353 patients referred to a regional endocrinology centre in New Zealand from March 2013 to November 2014 for new onset thyrotoxicosis...
March 22, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29555798/the-solution-of-the-sixth-hilbert-problem-the-ultimate-galilean-revolution
#14
REVIEW
Giacomo Mauro D'Ariano
I argue for a full mathematization of the physical theory, including its axioms, which must contain no physical primitives. In provocative words: 'physics from no physics'. Although this may seem an oxymoron, it is the royal road to keep complete logical coherence, hence falsifiability of the theory. For such a purely mathematical theory the physical connotation must pertain only the interpretation of the mathematics, ranging from the axioms to the final theorems. On the contrary, the postulates of the two current major physical theories either do not have physical interpretation (as for von Neumann's axioms for quantum theory), or contain physical primitives as 'clock', 'rigid rod', 'force', 'inertial mass' (as for special relativity and mechanics)...
April 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29554317/stereotactic-radiosurgery-for-benign-world-health-organization-grade-i-cavernous-sinus-meningiomas-international-stereotactic-radiosurgery-society-isrs-practice-guideline-a-systematic-review
#15
Cheng-Chia Lee, Daniel M Trifiletti, Arjun Sahgal, Antonio DeSalles, Laura Fariselli, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martínez Álvarez, Ian Paddick, Jean Regis, Samuel Ryu, Ben Slotman, Jason Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) has become popular as a standard treatment for cavernous sinus (CS) meningiomas. OBJECTIVE: To summarize the published literature specific to the treatment of CS meningioma with SRS found through a systematic review, and to create recommendations on behalf of the International Stereotactic Radiosurgery Society. METHODS: Articles published from January 1963 to December 2014 were systemically reviewed...
March 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29543397/alternative-rna-splicing-of-leukocyte-tissue-transglutaminase-in-celiac-disease
#16
Ana Hernández, Paula Arbildi, Cecilia Sóñora, Natalia Del Río, Juan Martin Marques
Tissue transglutaminase is a ubiquitous and multifunctional protein that contribute to several processes such as apoptosis/survival, efferocytosis, inflammation and tissue repairing under physiological and pathological conditions. Several activities can be associated with well established functional domains; in addition, four RNA alternative splice variants have been described, characterized by sequence divergences and residues deletion at the C-terminal domains Tissue transglutaminase is recognized as the central player in the physiopathology of celiac disease mainly through calcium dependent enzymatic activities...
March 15, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29541338/current-state-of-commercial-wearable-technology-in-physical-activity-monitoring-2015-2017
#17
EDITORIAL
Jennifer A Bunn, James W Navalta, Charles J Fountaine, Joel D Reece
Wearable physical activity trackers are a popular and useful method to collect biometric information at rest and during exercise. The purpose of this systematic review was to summarize recent findings of wearable devices for biometric information related to steps, heart rate, and caloric expenditure for several devices that hold a large portion of the market share. Searches were conducted in both PubMed and SPORTdiscus. Filters included: humans, within the last 5 years, English, full-text, and adult 19+ years...
2018: International Journal of Exercise Science
https://www.readbyqxmd.com/read/29538255/the-role-of-radiotherapy-in-extramammary-paget-disease-a-systematic-review
#18
L Tagliaferri, C Casà, G Macchia, A Pesce, G Garganese, B Gui, G Perotti, S Gentileschi, F Inzani, R Autorino, S Cammelli, A G Morganti, V Valentini, M A Gambacorta
OBJECTIVE/PURPOSE: Extramammary Paget disease (EMPD) is a rare neoplasm of the skin generally affecting the anogenital area. Because of the low-frequency of the disease, no specific guidelines about the treatment strategy are available. Surgery is the recommended therapy for resectable and localized disease, but several other local treatments have been reported such as radiotherapy (RT). Most articles report small retrospective studies, referring to patients treated decades ago with large heterogeneity in terms of RT dose and technique...
March 17, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29536455/meta-analysis-of-timing-for-microsurgical-free-flap-reconstruction-for-lower-limb-injury-evaluation-of-the-godina-principles
#19
Siba Haykal, Mélissa Roy, Ashit Patel
BACKGROUND:  In 1986, Marko Godina published his seminal work regarding the timing of free-flap reconstruction for traumatic extremity defects. Early reconstruction, compared with delayed and late reconstruction resulted in significant decreases in free-flap failure rate, post-operative infections, hospitalization time, bone healing time, and number of additional anesthesias. The objective of this manuscript was to evaluate whether these principles continue to apply. METHODS:  A meta-analysis was performed analyzing articles from Medline, Embase, and Pubmed...
February 2, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29510969/using-google-glass-in-surgical-settings-systematic-review
#20
REVIEW
Nancy J Wei, Bryn Dougherty, Aundria Myers, Sherif M Badawy
BACKGROUND: In recent years, wearable devices have become increasingly attractive and the health care industry has been especially drawn to Google Glass because of its ability to serve as a head-mounted wearable device. The use of Google Glass in surgical settings is of particular interest due to the hands-free device potential to streamline workflow and maintain sterile conditions in an operating room environment. OBJECTIVE: The aim is to conduct a systematic evaluation of the literature on the feasibility and acceptability of using Google Glass in surgical settings and to assess the potential benefits and limitations of its application...
March 6, 2018: JMIR MHealth and UHealth
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