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https://www.readbyqxmd.com/read/28531339/limtox-a-web-tool-for-applied-text-mining-of-adverse-event-and-toxicity-associations-of-compounds-drugs-and-genes
#1
Andres Cañada, Salvador Capella-Gutierrez, Obdulia Rabal, Julen Oyarzabal, Alfonso Valencia, Martin Krallinger
A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in pharmacological and biological research, only a limited number of freely available chemical text-mining/search engine technologies are currently accessible. Here we present LimTox (Literature Mining for Toxicology), a web-based online biomedical search tool with special focus on adverse hepatobiliary reactions...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28526905/effectiveness-of-acellular-dermal-matrix-on-autologous-split-thickness-skin-graft-in-treatment-of-deep-tissue-defect-esthetic-subjective-and-objective-evaluation
#2
Yoo Jung Lee, Myong Chul Park, Dong Ha Park, Hyung Min Hahn, Sue Min Kim, Il Jae Lee
BACKGROUND: A split-thickness skin graft (STSG) is performed to cover a large full-thickness skin defect. Esthetic and functional deficits can result, and many studies have sought to overcome them. This study compared the effectiveness of the acellular dermal matrix (ADM) graft and STSG concerning esthetic and functional effectiveness of ADM on scar quality. METHODS: Of the patients who underwent anterolateral thigh free flap from 2011 to 2015, patients who received skin graft only (n = 10) or skin graft with ADM (n = 20) for coverage of the donor site were enrolled...
May 19, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28500967/a-systematic-review-on-potential-mechanisms-of-minocycline-in-kidney-diseases
#3
REVIEW
Hamed Haghi-Aminjan, Mohammad Hossein Asghari, Mohammad Hadi Goharbari, Mohammad Abdollahi
Kidney diseases need specialized health care and still are a reason of death. There is a large body of evidence that indicates minocycline possesses some cytoprotective effects beside of antibacterial properties. In this review, we aimed to explain cytoprotective mechanisms and kidney protection of minocycline. In order to find the effects of minocycline on kidney diseases a systematic literature search was performed, according to the guidelines proposed at the PRISMA statement in the electronic databases, including: PubMed, Scopus, and Web of Science up to August 2016, using the term 'minocycline' combined either by 'kidney' or 'renal' and published in English language...
February 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28475086/timing-of-soft-tissue-management-around-dental-implants-a-suggested-protocol
#4
Mahdi Kadkhodazadeh, Reza Amid, Mehdi Ekhlasmand Kermani, Mahdieh Mirakhori, Sepanta Hosseinpour
Survival of dental implants depends on several factors; soft tissue (ST) management around dental implants is one of the foremost. Several studies have suggested techniques for ST management around dental implants, but none of them has discussed a suitable timetable for this process. This study aimed to review published articles related to the timing of ST management around dental implants and suggest a customized treatment protocol. A search of the PubMed database was conducted; the search was limited to English-language articles published from January 1995 to July 2015 with available full texts...
May 2017: General Dentistry
https://www.readbyqxmd.com/read/28456350/what-are-the-benefits-and-harms-of-ureteroscopy-compared-with-shock-wave-lithotripsy-in-the-treatment-of-upper-ureteral-stones-a-systematic-review
#5
REVIEW
Tamsin Drake, Nikolaos Grivas, Saeed Dabestani, Thomas Knoll, Thomas Lam, Steven Maclennan, Ales Petrik, Andreas Skolarikos, Michael Straub, Christian Tuerk, Cathy Yuhong Yuan, Kemal Sarica
CONTEXT: Extracorporeal shock wave lithotripsy (SWL) and ureteroscopy (URS), with or without intracorporeal lithotripsy, are the most common treatments for upper ureteric stones. With advances in technology, it is unclear which treatment is most effective and/or safest. OBJECTIVE: To systematically review literature reporting benefits and harms of SWL and URS in the management of upper ureteric stones. EVIDENCE ACQUISITION: Databases including Medline, Embase, and the Cochrane library were searched from January 2000 to November 2014...
April 26, 2017: European Urology
https://www.readbyqxmd.com/read/28445597/taller-height-as-a-risk-factor-for-venous-thromboembolism-a-mendelian-randomization-meta-analysis
#6
N S Roetker, S M Armasu, J S Pankow, P L Lutsey, W Tang, M A Rosenberg, T M Palmer, R F MacLehose, S R Heckbert, M Cushman, M de Andrade, A R Folsom
BACKGROUND: Taller height is associated with greater risk of venous thromboembolism (VTE). OBJECTIVES: We used instrumental variable (IV) techniques (Mendelian randomization) to further explore this relationship METHODS: Participants of European ancestry were included from two cohort studies [Atherosclerosis Risk in Communities (ARIC) study and Cardiovascular Health Study (CHS)] and one case-control study [Mayo Clinic VTE Study (Mayo)]. We created two weighted genetic risk scores (GRS) for height; the full GRS included 668 single nucleotide polymorphisms (SNPs) from a previously published meta-analysis and the restricted GRS included a subset of 362 SNPs not associated with weight independently of height...
April 26, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28441940/clinical-records-anonymisation-and-text-extraction-crate-an-open-source-software-system
#7
REVIEW
Rudolf N Cardinal
BACKGROUND: Electronic medical records contain information of value for research, but contain identifiable and often highly sensitive confidential information. Patient-identifiable information cannot in general be shared outside clinical care teams without explicit consent, but anonymisation/de-identification allows research uses of clinical data without explicit consent. RESULTS: This article presents CRATE (Clinical Records Anonymisation and Text Extraction), an open-source software system with separable functions: (1) it anonymises or de-identifies arbitrary relational databases, with sensitivity and precision similar to previous comparable systems; (2) it uses public secure cryptographic methods to map patient identifiers to research identifiers (pseudonyms); (3) it connects relational databases to external tools for natural language processing; (4) it provides a web front end for research and administrative functions; and (5) it supports a specific model through which patients may consent to be contacted about research...
April 26, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28439932/photophysical-characterization-of-tolyporphin-a-a-naturally-occurring-dioxobacteriochlorin-and-synthetic-oxobacteriochlorin-analogues
#8
Don Hood, Dariusz M Niedzwiedzki, Ran Zhang, Yunlong Zhang, Jingqiu Dai, Eric S Miller, David F Bocian, Philip G Williams, Jonathan S Lindsey, Dewey Holten
Tolyporphins are tetrapyrrole macrocycles produced by a cyanobacterium-containing culture known as HT-58-2. Tolyporphins A-J are free base dioxobacteriochlorins whereas tolyporphin K is an oxochlorin. Here, the photophysical characterization is reported of tolyporphin A and two synthetic analogues, an oxobacteriochlorin and a dioxobacteriochlorin. The characterization (in toluene, diethyl ether, ethyl acetate, dichloromethane, 1-pentanol, 2-butanone, ethanol, methanol, N,N-dimethylformamide, and dimethylsulfoxide) includes static absorption and fluorescence spectra, fluorescence quantum yields, and time-resolved data...
April 25, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28428081/intraoperative-image-guidance-compared-with-free-hand-methods-in-adolescent-idiopathic-scoliosis-posterior-spinal-surgery-a-systematic-review-on-screw-related-complications-and-breach-rates
#9
Andrew Chan, Eric Parent, Karl Narvacan, Cindy San, Edmond Lou
BACKGROUND CONTEXT: Severe adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity requiring surgery to stop curve progression. Posterior spinal instrumentation and fusion with pedicle screws is the standard surgery for AIS curve correction. Vascular and neurologic complications related to screw malpositioning are concerns in surgeries for AIS. Breach rates are reported at 15.7%, implant-related complications at 1.1%, and neurologic deficit at 0.8%. Free-hand screw insertion remains the prevailing method of screw placement, whereas image guidance has been suggested to improve placement accuracy...
April 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28422619/the-role-of-the-school-nurse-in-the-special-education-process-part-i-student-identification-and-evaluation
#10
Catherine F Yonkaitis, Robin A Shannon
Every U.S. student is entitled to a free and appropriate education. School districts must identify and evaluate any child who they find is unable to engage fully in learning as a participant in the general education curriculum. The Individuals with Disabilities Education Act of 2004 requires that these students be assessed by qualified individuals in any areas that may be impacting learning, including health, vision, hearing, social and emotional status, communicative status, and motor abilities. The school nurse, as the health expert, has an important role to play as a member of the special education team in evaluating whether a student has health concerns that are impacting learning and how health barriers to learning might be reduced...
May 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28418590/control-of-biofouling-by-xanthine-oxidase-on-seawater-reverse-osmosis-membranes-from-a-desalination-plant-enzyme-production-and-screening-of-bacterial-isolates-from-the-full-scale-plant
#11
Veena Nagaraj, Lucy Skillman, Dan Li, Zhangwang Xie, Goen Ho
Control of biofouling on seawater reverse osmosis (SWRO) membranes is a major challenge as treatments can be expensive, damage the membrane material and often biocides do not remove the polymers in which bacteria are embedded. Biological control has been largely ignored for biofouling control. The objective of this study was to demonstrate the effectiveness of xanthine oxidase enzyme against complex fouling communities and then identify naturally occurring bacterial strains that produce the free radical generating enzyme...
April 18, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28393635/assessment-of-environmental-policy-implementation-in-solid-waste-management-in-kathmandu-nepal
#12
Mohan B Dangi, Erica Schoenberger, John J Boland
In Nepal, full-fledged environmental legislation was rare before the democratic constitution of 1990. The first law covering the environment and sustainability was the Environment Protection Act 1997. While the Solid Waste Act was introduced in 1987, the problem of solid waste management still surfaces in Kathmandu. In order to understand the bedrock of this unrelenting failure in solid waste management, the manuscript digs deeper into policy implementation by dissecting solid waste rules, environmental legislations, relevant local laws, and solid waste management practices in Kathmandu, Nepal...
April 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28390153/on-the-fine-tuning-of-the-excited-state-intramolecular-proton-transfer-esipt-process-in-2-2-hydroxybenzofuran-benzazole-hbbx-dyes
#13
Elodie Heyer, Karima Benelhadj, Simon Budzák, Denis Jacquemin, Julien Massue, Gilles Ulrich
Herein, a full investigation of the optical properties and first-principles calculations of a large series of original 2-(2'-hydroxybenzofuran)benzazole (HBBX) dyes is described. The electronic substitution on the π-conjugated core of the fluorophores and the nature of the heteroatom (O, S, N) was varied extensively to assess the necessary parameters to trigger a partial frustration of the excited-state intramolecular proton transfer (ESIPT) process, which results in the emission of both tautomers, that is, enol and keto (E* and K*)...
April 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28374304/septum-enhanced-mammaplasty-in-inferocentral-pedicled-breast-reduction-for-macromastia-and-gigantomastia-patients
#14
Aurelio Portincasa, Francesco Ciancio, Luigi Cagiano, Alessandro Innocenti, Domenico Parisi
BACKGROUND: Inferior pedicle and free nipple grafting are commonly used as breast reduction techniques for patients with breast hypertrophy and gigantomastia. Limitations of these techniques are, respectively, possible vascular compromise and total/partial necrosis of the nipple-areola complex (NAC). The authors describe the innovative inferocentral pedicled reduction mammaplasty (ICPBR) enhanced by preservation of Würinger's septum for severe hypertrophic breasts. MATERIALS AND METHODS: Among 287 breast reductions performed between January 2001 and 2015, 83 (28...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28341946/surgical-masculinization-of-the-breast-clinical-classification-and-surgical-procedures
#15
Lazaro Cardenas-Camarena, Carlos Dorado, Maria Teresa Guerrero, Rosa Nava
INTRODUCTION: Aesthetic breast area improvements for gynecomastia and gender dysphoria patients who seek a more masculine appearance have increased recently. We present our clinical experience in breast masculinization and a classification for these patients. METHODS AND MATERIALS: From July 2003 to May 2014, 68 patients seeking a more masculine thorax underwent surgery. They were divided into five groups depending on three factors: excess fatty tissue, breast tissue, and skin...
June 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28327849/-effect-of-free-roaming-dogs-culling-on-the-control-of-canine-rabies
#16
Ricardo Castillo-Neyra, Michael Z Levy, Cesar Náquira
In the Peruvian city of Arequipa, rabid dogs have been detected since March 2015, signaling the reintroduction of the rabies virus (RV) in this previously officially-declared rabies free zone. High dog density is considered one of the causes for the continuous transmission of the RV in the outbreak in the city of Arequipa, which seemingly lends support to the culling of dogs as a public health measure. However, the effectiveness of culling free-roaming dogs to control urban rabies has not been evaluated. Objective to determine the effectiveness of free-roaming dog culling as a control measure of urban rabies...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28318130/blue-nevus-like-and-blue-nevus-associated-melanoma-a-comprehensive-review-of-the-literature
#17
REVIEW
Thore L Borgenvik, Tina M Karlsvik, Saikat Ray, Monica Fawzy, Nick James
BACKGROUND: Malignant blue nevus, blue nevus-associated melanoma and blue nevus-like melanoma are all terms used to describe malignant melanomas arising from, in association with, or resembling blue nevi. This review is aimed at summarizing the available literature to reduce the confusion surrounding this rare malignancy, and aid the surgeon in choosing further diagnostic or therapeutic measures. METHODS: We conducted a search of Medline, Embase, Science Direct, Scopus and the Cochrane Library for all full text articles published in English that reported on a malignant melanoma arising from, in association with, or resembling a blue nevus...
May 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28317125/referenceless-magnetic-resonance-temperature-imaging-using-gaussian-process-modeling
#18
Joshua P Yung, David Fuentes, Christopher J MacLellan, Florian Maier, Yannis Liapis, John D Hazle, R Jason Stafford
PURPOSE: During magnetic resonance (MR)-guided thermal therapies, water proton resonance frequency shift (PRFS) based MR temperature imaging can quantitatively monitor tissue temperature changes. It is widely known that the PRFS technique is easily perturbed by tissue motion, tissue susceptibility changes, magnetic field drift, and modality-dependent applicator induced artifacts. Here a referenceless Gaussian process modeling (GPM) based estimation of the PRFS is investigated as a methodology to mitigate unwanted background field changes...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28296054/modified-retroperitoneal-lymph-node-dissection-for-postchemotherapy-residual-tumor-a-long-term-update
#19
Jane S Cho, Hristos Z Kaimakliotis, K Clint Cary, Timothy A Masterson, Stephen Beck, Richard Foster
OBJECTIVES: To update previously reported outcomes of modified template postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in appropriately selected patients with metastatic non-seminomatous germ cell tumor (NSGCT). Our previous report was criticized for short follow-up. Herein, we provide a long-term update on this cohort. MATERIALS AND METHODS: One hundred patients with normal serum markers after cisplatin-based chemotherapy and residual retroperitoneal tumor underwent modified PC-RPLND between 1991 and 2004...
March 13, 2017: BJU International
https://www.readbyqxmd.com/read/28292569/indocyanine-green-applications-in-plastic-surgery-a-review-of-the-literature
#20
Pierre Burnier, Jérémy Niddam, Romain Bosc, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Use of indocyanine green (ICG) near-infrared fluorescence as a dye to assess tissue vascularization is now well standardized. The aim of this literature review was to review and resume the most recent recommendations for ICG use in its plastic surgery applications. METHODS: A systematic literature review was performed using Medline, EMBASE, and PubMed databases to obtain the latest recommendations for ICG in plastic surgery. Inclusion criteria were all articles written in English language that evaluated pre-, intra-, or postoperative ICG applications in surgical procedures usually performed by plastic surgeons...
June 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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