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https://www.readbyqxmd.com/read/28101641/volumetric-growth-rates-of-meningioma-and-its-correlation-with-histological-diagnosis-and-clinical-outcome-a-systematic-review
#1
REVIEW
Daniel M Fountain, Wai Cheong Soon, Tomasz Matys, Mathew R Guilfoyle, Ramez Kirollos, Thomas Santarius
INTRODUCTION: Tumour growth has been used to successfully predict progression-free survival in low-grade glioma. This systematic review sought to establish the evidence base regarding the correlation of volumetric growth rates with histological diagnosis and potential to predict clinical outcome in patients with meningioma. METHODS: This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
January 18, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28099274/can-any-patients-with-chronic-myeloid-leukemia-outside-of-a-clinical-trial-have-their-tyrosine-kinase-inhibitor-discontinued
#2
Michael J Mauro
PURPOSE OF REVIEW: This article critically appraises the state of treatment-free remission as a strategy for patients with chronic myeloid leukemia (CML) in deep remission after therapy with tyrosine kinase inhibitors (TKIs). RECENT FINDINGS: Approximately half of patients with CML defined fairly narrowly by trial criteria - TKI sensitive, in deep molecular remission for a defined period - can successfully maintain protective levels of response after TKI cessation...
January 17, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28077563/the-bioc-biogrid-corpus-full-text-articles-annotated-for-curation-of-protein-protein-and-genetic-interactions
#3
Rezarta Islamaj Doğan, Sun Kim, Andrew Chatr-Aryamontri, Christie S Chang, Rose Oughtred, Jennifer Rust, W John Wilbur, Donald C Comeau, Kara Dolinski, Mike Tyers
A great deal of information on the molecular genetics and biochemistry of model organisms has been reported in the scientific literature. However, this data is typically described in free text form and is not readily amenable to computational analyses. To this end, the BioGRID database systematically curates the biomedical literature for genetic and protein interaction data. This data is provided in a standardized computationally tractable format and includes structured annotation of experimental evidence. BioGRID curation necessarily involves substantial human effort by expert curators who must read each publication to extract the relevant information...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28064446/depression-screening-tools-in-persons-with-epilepsy-a-systematic-review-of-validated-tools
#4
REVIEW
Stephanie J Gill, Sara Lukmanji, Kirsten M Fiest, Scott B Patten, Samuel Wiebe, Nathalie Jetté
OBJECTIVE: Depression affects approximately 25% of epilepsy patients. However, the optimal tool to screen for depression in epilepsy has not been definitively established. The purpose of this study was to systematically review the literature on the validity of depression-screening tools in epilepsy. METHODS: MEDLINE, EMBASE, and PsycINFO were searched until April 4, 2016 with no restriction on dates. Abstract, full-text review and data abstraction were conducted in duplicate...
January 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28060730/prognostic-value-of-micrornas-in-osteosarcoma-a-meta-analysis
#5
Yun Hak Kim, Tae Sik Goh, Chi-Seung Lee, Sae Ock Oh, Jeung Il Kim, Seung Hyeon Jeung, Kyoungjune Pak
BACKGROUND: Osteosarcoma is the most common primary bone malignancy. We meta-analyzed the prognostic value of altered miRNAs in patients with osteosarcoma. METHODS: Sources from MEDLINE (from inception to August 2016) and EMBASE (from inception to August 2016) were searched. Studies of osteosarcoma with results of miRNA and studies that reported survival data were included and two authors performed the data extraction independently. Any discrepancies were resolved by a consensus...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28033626/-overview-and-introduction-of-a-treatment-concept-for-postoperative-care-and-mobilisation-after-free-flap-transplantation-in-the-lower-extremity
#6
M Cerny, J-T Schantz, H Erne, D Schmauss, R E Giunta, H-G Machens, T Schenck
Introduction: Free flap transplants for soft tissue reconstruction in the lower extremity are associated with a higher rate of complications compared with other areas. Mobilisation and the resulting hydrostatic pressure put strain on the flaps. In general, these effects are countered by slowly increasing hydrostatic pressure with the leg being compressed by elastic bandages. These postoperative regimes are also called dangling procedures or "flap training", but are not scientifically validated and therefore there is no consensus or guideline leading to a standard treatment regime...
December 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28032178/comparison-of-aesthetic-outcomes-between-vertical-and-horizontal-flap-insets-in-breast-reconstruction-with-the-tram-or-diep-flaps
#7
Woo Shik Jeong, Wooyeon Han, Jin Sup Eom
BACKGROUND: Tissue transfer, such as use of the transverse rectus abdominis myocutaneous (TRAM) or deep inferior epigastric artery perforator (DIEP) free flaps, is considered a standard method. However, outcomes may vary among inset methods. Here we compared the aesthetic outcomes of breast reconstructions using vertical and horizontal flap inset methods. METHODS: We, respectively, reviewed 274 patients who underwent unilateral post-mastectomy breast reconstruction using TRAM or DIEP free flaps between April 2006 and December 2013...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28017261/is-sentinel-lymph-node-biopsy-warranted-for-desmoplastic-melanoma-a-systematic-review
#8
REVIEW
Jonathan A Dunne, Justin C R Wormald, Jessica Steele, Elizabeth Woods, Joy Odili, Barry W E M Powell
BACKGROUND: Desmoplastic melanoma (DM) is an uncommon malignancy associated with a high local recurrence rate. The aim of this systematic review was to determine the positivity rate of sentinel lymph node biopsy (SLNB) in patients with DM. The secondary outcome was to establish if SLNB is warranted for both pure DM (PDM) and mixed DM (MDM). METHODS: A full systematic literature review of SLNB in DM was performed by two authors in January 2016. Ovid MEDLINE, Ovid EMBASE and the Cochrane Central Register of Controlled Trials were searched...
November 16, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27992023/educational-strategies-for-the-prevention-of-diabetes-hypertension-and-obesity
#9
Alexandre Paulo Machado, Bruno Muniz Lima, Monique Guilharducci Laureano, Pedro Henrique Bauth Silva, Giovanna Pereira Tardin, Paulo Silva Reis, Joyce Sammara Santos, Domingos Jácomo, Eliziana Ferreira D'Artibale
Objective: The main goal of this work was to produce a review of educational strategies to prevent diabetes, hypertension, and obesity. Method: PubMed database was consulted using combined descriptors such as [Prevention], [Educational Activities], [Diabetes], [Hypertension], and [Obesity]. Data from randomized trials published between 2002 and 2014 were included in spreadsheets for analysis in duplicate by the reviewers. Results: A total of 8,908 articles were found, of which 1,539 were selected about diabetes mellitus (DM, n=369), arterial systemic hypertension (ASH, n=200), and obesity (OBES, n=970)...
November 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27987018/-osteosynthesis-of-distal-fibular-fractures-with-illuminoss-video-article
#10
M Zyskowski, M Crönlein, E Heidt, P Biberthaler, C Kirchhoff
OBJECTIVE: The aim was minimally invasive osteosynthesis of a distal fibular fracture under the premises of poor soft tissue conditions and existing chronic comorbidities to enable rapid recovery and to reduce soft tissue stress in order to avoid postoperative infections and achieve early weight bearing. INDICATIONS: This involved a distal fibula fracture, classified as 44 B1.1, B1.2, B1.3 according to the working group for osteosynthesis (AO) or a B fracture after Danis and Weber with indications for surgery (cortical disruption and shaft offset > 5 mm), age > 65 years, poor soft tissue conditions and a Charlson score ≥ 1...
January 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/27958479/interferometric-surface-mapping-of-a-spherical-proof-mass-for-ultra-precise-inertial-reference-sensors
#11
Harald Kögel, Dennis Weise, Alexander Sell, Ewan Fitzsimons, Domenico Gerardi, Ulrich Johann, Claus Braxmaier
In the context of our investigations on novel inertial reference sensors for space applications, we have explored a design utilizing an optical readout of a spherical proof mass. This concept enables full drag-free operations, hence reducing proof mass residual acceleration noise to a minimum. The main limitations of this sensor are errors in position determination of the center of mass of the proof mass due to the surface topography and the involved path length changes upon rotation. One solution is to apply a surface map for correction of the measurement data, thus improving the precision of position determination...
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27909857/privacy-autonomy-and-public-policy-french-and-north-american-perspectives
#12
Jennifer Merchant
This article raises the question of whether in both the United States and in France, an individual's autonomy and private decision-making right(s) in matters of health care and access to reproductive technologies can be conciliated with the general interest, and more specifically, the role of the State. Can a full-fledged right to privacy, the ability to exercise one's autonomy, exist alongside the general interest, and depend neither on financial resources like in the United States nor on centralised government decisions or the medical hierarchy like in France? The contrast between these two modern democracies justify the importance of comparing them...
December 2016: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/27903039/management-of-bipolar-disorder-over-the-perinatal-period
#13
Philip Boyce, Anne Buist
BACKGROUND: Women with bipolar disorder have a high risk of relapse following childbirth. The risk of relapse can be reduced by mood stabilisers, but they are potentially harmful to the developing fetus. OBJECTIVE: The objective of this article is to provide an up-to-date review of the strategies for managing women with bipolar disorder over the perinatal period. DISCUSSION: Discussing the risks of taking mood stabilisers or having a medication-free pregnancy is essential for women with bipolar disorder...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#14
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27873387/physical-exercise-remodels-visceral-adipose-tissue-and-mitochondrial-lipid-metabolism-in-rats-fed-a-high-fat-diet
#15
Sílvia Rocha-Rodrigues, Amaia Rodríguez, Sara Becerril, Beatriz Ramírez, I O Gonçalves, Jorge Beleza, Gema Frühbeck, António Ascensão, José Magalhães
We aimed to investigate the effects of two physical exercise models, voluntary physical activity (VPA) and endurance training (ET) as preventive and therapeutic strategies, respectively, on lipid accumulation regulators and mitochondrial content in VAT of rats fed a high-fat diet (HFD). Sprague Dawley rats (6 wks old, n=60) were assigned into sedentary and VPA groups fed isoenergetic diets: standard (S, 35 kcal% fat) or HFD (71 kcal% fat). The VPA groups had free access to wheel running during the entire protocol...
November 22, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27873018/soft-tissue-augmentation-around-osseointegrated-and-uncovered-dental-implants-a-systematic-review
#16
REVIEW
Renzo G Bassetti, Alexandra Stähli, Mario A Bassetti, Anton Sculean
OBJECTIVES: The aim was to compile the current knowledge about the efficacy of different soft tissue correction methods around osseointegrated, already uncovered and/or loaded (OU/L) implants with insufficient soft tissue conditions. Procedures to increase peri-implant keratinized mucosa (KM) width and/or soft tissue volume were considered. MATERIALS AND METHODS: Screening of two databases: MEDLINE (PubMed) and EMBASE (OVID), and manual search of articles were performed...
January 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27870656/oscillometric-and-auscultatory-blood-pressure-measurement-methods-in-children-a-systematic-review-and-meta-analysis
#17
Stephanie L Duncombe, Christine Voss, Kevin C Harris
BACKGROUND: The phase-out of mercury from clinical settings calls for valid alternatives to assess blood pressure (BP) in children. Aneroid devices provide a mercury-free alternative to BP measurements by auscultation, whereas oscillometric (automated) devices are increasingly becoming the norm in clinical practice due to their ease of use. The aim of this systematic review and meta-analysis was to investigate the accuracy of oscillometric and aneroid BP devices compared with the mercury sphygmomanometer for the measurement of BP in children...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27869298/informant-questionnaire-on-cognitive-decline-in-the-elderly-iqcode-for-the-early-diagnosis-of-dementia-across-a-variety-of-healthcare-settings
#18
REVIEW
Jennifer K Harrison, David J Stott, Rupert McShane, Anna H Noel-Storr, Rhiannon S Swann-Price, Terry J Quinn
BACKGROUND: The Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) is a structured interview based on informant responses that is used to assess for possible dementia. IQCODE has been used for retrospective or contemporaneous assessment of cognitive decline. There is considerable interest in tests that may identify those at future risk of developing dementia. Assessing a population free of dementia for the prospective development of dementia is an approach often used in studies of dementia biomarkers...
21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27846741/creating-an-inclusive-leisure-space-strategies-used-to-engage-children-with-and-without-disabilities-in-the-arts-mediated-program-spiral-garden
#19
Eric Smart, Brydne Edwards, Shauna Kingsnorth, Sarah Sheffe, C J Curran, Madhu Pinto, Shannon Crossman, Gillian King
PURPOSE: This article describes how service providers use a set of practical strategies to create an inclusive leisure space in Spiral Garden, an arts-mediated outdoor summer day program for children with and without disabilities. METHODS: This study was guided by an interpretive qualitative approach. Fourteen Spiral Garden service providers participated in semi-structured interviews. Nine had extensive experience with the program and had been present during key phases of program development spanning over a 26-year period and five were service providers during the summer of 2013...
November 16, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27835987/clinicopathological-and-prognostic-significance-of-mtor-and-phosphorylated-mtor-expression-in-patients-with-esophageal-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#20
Shuangjiang Li, Zhiqiang Wang, Jian Huang, Shan Cheng, Heng Du, Guowei Che, Yong Peng
BACKGROUND: Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase responsible for regulating ribosomal biogenesis and protein synthesis. Dysregulation of mTOR contributes to tumorigenesis, angiogenesis, cellular growth and metastasis but its roles in esophageal squamous cell carcinoma (ESCC) are controversial. Therefore, the objective of this study is to evaluate the prognostic and clinicopathological significance of mTOR/p-mTOR expression in ESCC. METHODS: Literature retrieval was conducted by searching PubMed, EMBASE and the Web of Science for full-text papers that met our eligibility criteria...
November 11, 2016: BMC Cancer
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