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fat embolism syndrome

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https://www.readbyqxmd.com/read/28096988/successful-outcome-of-three-patients-with-sickle-cell-disease-and-fat-embolism-syndrome-treated-with-intensive-exchange-transfusion
#1
Paul Greaves, Vivek Mathew, Catherine Peters, Susan Rowe, Roger J Amos, Dimitris A Tsitsikas
Fat embolism syndrome (FES) is a rare complication of sickle-cell disease (SCD) associated with extremely high mortality rates. It affects predominantly non-SS patients and those with previously mild disease. Rapid institution of exchange transfusion with an aim to reduce HbS to very low levels as soon as FES is suspected can be life-saving.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28050810/erratum-to-role-of-interleukin-6-as-an-early-marker-of-fat-embolism-syndrome-a-clinical-study
#2
Shiva Prakash, Ramesh Kumar Sen, Sujit Kumar Tripathy, Indu Mohini Sen, R R Sharma, Sadhna Sharma
No abstract text is available yet for this article.
January 3, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28018064/cortical-blindness-along-with-motor-aphasia-an-unusual-presentation-of-fat-embolism-syndrome
#3
Umesh Kumar Meena, Ravinder Kumar Lamoria, Ravi Kant Millan, Piyush Agarwal, Mahendra Singh, Mahesh Chand Bansal
Fat embolism syndrome presented with the classical triad of respiratory manifestations (95%), cerebral effects (60%) and Petechial rash (33%). Focal neurological symptoms in the form of combined bilateral cortical blindness and motor aphasia even prior to respiratory symptoms have been never reported in previous literature. We describe a case of these rare focal neurological symptoms secondary to the fat embolism syndrome in a young adult male following closed femur fracture.
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28005103/fat-embolism-syndrome-with-cerebral-fat-embolism-associated-with-long-bone-fracture
#4
Steven F DeFroda, Stephen A Klinge
Fat embolism syndrome (FES) is a well-known sequela of long-bone fracture and fixation. FES most commonly affects the pulmonary system. Brain emboli may lead to a symptomatic cerebral fat embolism (CFE), which is devastating. In this article, we review the presentation, causes, and management of FES presenting with CFE, report a case, and review the literature. The case involved an otherwise healthy 42-year-old woman who developed CFE after reamed intramedullary nail fixation of femoral and tibial shaft fractures during a single operation...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27984227/physical-compatibility-of-propofol-sufentanil-mixtures
#5
Jarmila Zbytovská, Jana Gallusová, Lucie Vidlářová, Kamila Procházková, Jan Šimek, František Štěpánek
BACKGROUND: Combined infusions of propofol and sufentanil preparations are frequently used in clinical practice to induce anesthesia and analgesia. However, the stability of propofol emulsions can be affected by dilution with another preparation, sometimes leading to particle coalescence and enlargement. Such unwanted effects can lead to fat embolism syndrome after intravenous application. This study describes the physical stability of 5 commercially available propofol preparations mixed with sufentanil citrate solutions...
December 15, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27779587/the-renin-inhibitor-aliskiren-protects-rat-lungs-from-the-histopathological-effects-of-fat-embolism
#6
Amanda N Fletcher, Agostino Molteni, Rakesh Ponnapureddy, Chirag Patel, Mark Pluym, Alan M Poisner
BACKGROUND: Fat embolism (FE) and the consequent fat embolism syndrome (FES) occurring after trauma or surgery can lead to serious pulmonary injury, including ARDS and death. Current treatment of FES is limited to supportive therapy. We have shown in a rat model that the renin angiotensin system (RAS) plays a significant role in the pathophysiology of FE since drugs interfering with the RAS, captopril and losartan, reduce the histopathologic pulmonary damage. The purpose of the current study was to determine if inhibition of renin by aliskiren, an FDA-approved drug for treating hypertension, would produce effective protection in the same model...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27722116/early-and-late-intramedullary-nailing-of-femur-fracture-a-single-center-experience
#7
Ahmad S Alobaidi, Ammar Al-Hassani, Ayman El-Menyar, Husham Abdelrahman, Mazin Tuma, Hassan Al-Thani, Mohammed A Aldosari
BACKGROUND: Femur fracture (FF) is a common injury, and intramedullary nailing (IMN) is the standard surgical fixation. However, the time of intervention remains controversial. We aimed to describe the reamed IMN (rIMN) timing and hospital outcomes in trauma patients presenting with FF. MATERIALS AND METHODS: A retrospective analysis was conducted for all patients admitted with FF and they underwent fixation at level 1 trauma unit between January 2010 and January 2012...
July 2016: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/27624445/spinal-cord-infarction-as-a-rare-complication-of-fat-embolism-syndrome-following-bilateral-intramedullary-nailing-of-femur-fractures
#8
RoseMarie Kearsley, John Galbraith, David Dalton, Catherine Motherway
Fat embolism syndrome (FES) is a rare and potentially fatal complication occurring most often after long bone or pelvic fractures and orthopaedic procedures. It can consist of pulmonary, central nervous system and cutaneous manifestations. The exact pathophysiology of emboli reaching the arterial circulation is poorly understood.1 It is suggested that this may occur by either 'paradoxical' embolism or microembolism.2 3 Its true incidence is unknown but increases in the presence of multiple closed fractures...
September 13, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27598359/fat-embolism-syndrome-secondary-to-bone-marrow-necrosis-in-patients-with-hemoglobinopathies
#9
Radhika Gangaraju, Vishnu V B Reddy, Marisa B Marques
Bone marrow necrosis with subsequent embolization of the fat and necrotic tissues into the systemic circulation causing fat embolism syndrome and multiorgan failure is a rare complication of patients with hemoglobinopathies. The exact etiology of this condition is not known. Because it occurs more often in patients with compound heterozygous conditions than in sickle cell disease, some patients are unaware of their predisposition. The initial symptoms are nonspecific, such as back and/or abdominal pain, fever, and fatigue, which may rapidly progress to respiratory failure and severe neurologic compromise...
September 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27595520/recurrent-fat-embolic-strokes-in-a-patient-with-duchenne-muscular-dystrophy-with-long-bone-fractures-and-a-patent-foramen-ovale
#10
Christopher J Bugnitz, Linda H Cripe, Warren D Lo, Kevin M Flanigan
BACKGROUND: Individuals with Duchenne muscular dystrophy have an increased risk of long bone fractures. Such fractures are sometimes associated with brain dysfunction due to fat embolism syndrome, although this syndrome has seldom been documented in muscular dystrophy patients. PATIENT DESCRIPTION: We describe a child with Duchenne muscular dystrophy who developed fat embolism syndrome with neurological dysfunction following multiple long bone fractures. He experienced recurrent cerebral infarctions that probably resulted from embolization through a patent foramen ovale...
October 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27455237/the-effects-of-aquaporin-1-in-pulmonary-edema-induced-by-fat-embolism-syndrome
#11
Yiwei Zhang, Kun Tian, Yan Wang, Rong Zhang, Jiawei Shang, Wei Jiang, Aizhong Wang
This study was designed to investigate the role of aquaporin1 (AQP1) in the pathologic process of pulmonary edema induced by fat embolism syndrome (FES) and the effects of a free fatty acid (FFA) mixture on AQP1 expression in pulmonary microvascular endothelial cells (PMVECs). In vivo, edema was more serious in FES mice compared with the control group. The expression of AQP1 and the wet-to-dry lung weight ratio (W/D) in the FES group were significantly increased compared with the control group. At the same time, inhibition of AQP1 decreased the pathological damage resulting from pulmonary edema...
July 21, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27426712/patterns-of-orthopaedic-injuries-among-motorbike-accident-admissions-presenting-to-a-tertiary-care-hospital-in-kathmandu
#12
B Banskota, S Shrestha, R K Chaudhary, T Rajbhandari, S Rijal, B K Shrestha, A K Banskota
BACKGROUND: The anecdotal burden of morbidity secondary to motorbike accidents is thought to enormous by personnel involved in trauma care. The objective of the present study is to ascertain patterns and association of injuries and causes of mortality in a cohort of motorbike accident victims. METHODS: A retrospective chart review of 1337 motorbike accident admissions B and B Hospital in Kathmandu between January 2009 and December 2010 was undertaken. RESULTS: Majority of victims were between 20 to 50 years [1230 (92%) males]...
January 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27408408/sudden-death-in-sickle-cell-anaemia-report-of-three-cases-with-brief-review-of-literature
#13
Manickam Niraimathi, Rakhee Kar, Sajini Elizabeth Jacob, Debdatta Basu
Vaso-occlusive crisis in sickle cell anaemia is one of the commonest presentations and a leading cause of death. Death can be sudden and unexpected. Herein we present three cases of sickle cell anaemia with sudden death within 3 days of hospitalisation. All the three cases presented with fever and jaundice. Two cases presented consecutively in the same year within a span of 5 months while the other case had presented 2 years prior to these two cases. Infection was the precipitating event in two cases and pregnancy with infection in one...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27364276/the-corpus-callosum-and-forensic-issues-an-overview
#14
Roger W Byard
The corpus callosum is a large central white matter tract that connects the right and left cerebral hemispheres. It permits placental mammals to have a more sophisticated interhemispheric integration of sensory cortices and allows communication between cortical and subcortical neurons. Search of the literature and the pathology archives at The University of Adelaide was undertaken to identify lesions and injuries within the corpus callosum that may have forensic significance. These include developmental/congenital lesions with agenesis/dysgenesis, vascular malformations, and lipomas; inherited syndromes such as neurofibromatosis; and acquired lesions involving trauma, neoplasia, demyelination, vascular conditions, infections, fat embolism, aging/dementia, and the effects of toxins...
July 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27356663/cerebral-fat-embolism-syndrome-following-total-knee-replacement-causing-a-devastating-neurocognitive-sequelae
#15
Dareen S Al-Shaer, Omar Ayoub, Naushad A Ahamed, Amro M Al-Hibshi, Saleh S Baeesa
No abstract text is available yet for this article.
July 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/27321297/early-intramedullary-nailing-for-femoral-fractures-in-patients-with-severe-thoracic-trauma-a-systemic-review-and-meta-analysis
#16
Xiao-Yuan Liu, Meng Jiang, C-L Yi, Xiang-Jun Bai, David-J Hak
PURPOSE: Early intramedullary nailing (IMN) within the first 24 h for multiply injured patients with femoral fracture and concomitant thoracic trauma is controversial. Previously published studies have been limited in size and their outcomes have been inconclusive. A meta-analysis was conducted to evaluate the available data in order to guide care and help improve the outcomes for these patients. METHODS: We searched the literature up to December 2011 in the main medical search engines and identified 6 retrospective cohort studies that explored the safety of early IMN in patients with both femoral fracture and chest injury...
June 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/27108833/severe-fat-embolism-in-perioperative-abdominal-liposuction-and-fat-grafting
#17
Rodrigo de Lima E Souza, Bruno Tavares Apgaua, João Daniel Milhomens, Francisco Tadeu Motta Albuquerque, Luiz Antônio Carneiro, Márcio Henrique Mendes, Tiago Carvalho Garcia, Clerisson Paiva, Felipe Ladeia, Deiler Célio Jeunon
BACKGROUND AND OBJECTIVES: Fat embolism syndrome may occur in patients suffering from multiple trauma (long bone fractures) or plastic surgery (liposuction), compromising the circulatory, respiratory and/or central nervous systems. This report shows the evolution of severe fat embolism syndrome after liposuction and fat grafting. CASE REPORT: SSS, 42 years old, ASA 1, no risk factors for thrombosis, candidate for abdominal liposuction and breast implant prosthesis...
May 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27098324/use-of-the-reamer-irrigator-aspirator-decreases-carotid-and-cranial-embolic-events-in-a-canine-model
#18
Anna N Miller, Dwight Deal, James Green, Timothy Houle, William Brown, Clara Thore, David Stump, Lawrence X Webb
BACKGROUND: Approximately 2 million patients in the United States annually undergo total joint arthroplasty with reaming and placement of intramedullary nails, resulting in extravasation of bone marrow and fat into the circulatory system and potentially causing fat embolism syndrome. Acute and chronic changes in mental status documented after these procedures may be related to embolic events. The Reamer/Irrigator/Aspirator (RIA) device has been shown to decrease intramedullary pressure during reaming...
April 20, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27035513/systematic-review-of-clinical-adverse-events-reported-after-acute-intravenous-lipid-emulsion-administration
#19
Bryan D Hayes, Sophie Gosselin, Diane P Calello, Nicholas Nacca, Carol J Rollins, Daniel Abourbih, Martin Morris, Andrea Nesbitt-Miller, José A Morais, Valéry Lavergne
BACKGROUND: Intravenous lipid emulsions (ILEs) were initially developed to provide parenteral nutrition. In recent years, ILE has emerged as a treatment for poisoning by local anesthetics and various other drugs. The dosing regimen for the clinical toxicology indications differs significantly from those used for parenteral nutrition. The evidence on the efficacy of ILE to reverse acute toxicity of diverse substances consists mainly of case reports and animal experiments. Adverse events to ILE are important to consider when clinicians need to make a risk/benefit analysis for this therapy...
June 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/26938691/fat-embolism-syndrome-lung-computed-tomography-findings-in-18-patients
#20
Marco Piolanti, Giorgia Dalpiaz, Mariano Scaglione, Carlo Coniglio, Marco Miceli, Sara Violini, Rocco Trisolini, Libero Barozzi
OBJECTIVE: The purpose of this study was to evaluate the lung computed tomography (CT) findings in fat embolism (FE) syndrome. METHODS: We retrospectively evaluated 19 CT examinations of 18 patients with FE syndrome, diagnosed clinically using the Gurd and Wilson criteria. RESULT: Fat embolism syndrome showed 3 patterns: negative examination, bilateral interstitial-alveolar involvement, and adult respiratory distress syndrome like. Frequent findings included consolidations (17 patients), mostly with gravity dependent distribution, and ground-glass opacities (17 patients), mostly with patchy distribution...
May 2016: Journal of Computer Assisted Tomography
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