keyword
https://read.qxmd.com/read/38537437/penetrating-head-and-spine-injuries-due-to-artisanal-sahelian-metal-arrows-experience-from-a-tertiary-hospital-in-niger
#21
JOURNAL ARTICLE
Roufai Hamissou Moussa Maman, Sani Rabiou Mahaman, Amadou Hassane Ali, Beranger Hounkpatin Seton Stachys, Kelani Aminath
BACKGROUND AND OBJECTIVE: Metal arrows are medieval weapons typically used for hunting and war. The incidence of metal arrow wounds has declined considerably since the 16th century. Different metal arrowheads exist, and the traditional Sahelian arrowhead is barbed. Extraction of this type of metal arrow is challenging because of the risk of extensive damage to surrounding structures. To the best of our knowledge, there are no guidelines in the literature for intracranial and spinal penetrating Sahelian arrow injuries and their surgical extraction...
March 26, 2024: Neuro-Chirurgie
https://read.qxmd.com/read/38537300/decompression-illness-a-comprehensive-overview
#22
JOURNAL ARTICLE
Simon J Mitchell
Decompression illness is a collective term for two maladies (decompression sickness [DCS] and arterial gas embolism [AGE]) that may arise during or after surfacing from compressed gas diving. Bubbles are the presumed primary vector of injury in both disorders, but the respective sources of bubbles are distinct. In DCS bubbles form primarily from inert gas that becomes dissolved in tissues over the course of a compressed gas dive. During and after ascent ('decompression'), if the pressure of this dissolved gas exceeds ambient pressure small bubbles may form in the extravascular space or in tissue blood vessels, thereafter passing into the venous circulation...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38537119/constructing-linear-oriented-pre-vascularized-human-spinal-cord-tissues-for-spinal-cord-injury-repair
#23
JOURNAL ARTICLE
Caixia Fan, Hui Cai, Lulu Zhang, Xianming Wu, Junyan Yan, Lifang Jin, Baowei Hu, Jiaxiong He, Yanyan Chen, Yannan Zhao, Jianwu Dai
Repairing spinal cord injury (SCI) is a global medical challenge lacking effective clinical treatment. Developing human-engineered spinal cord tissues that can replenish lost cells and restore a regenerative microenvironment offers promising potential for SCI therapy. However, creating vascularized human spinal cord-like tissues that mimic the diverse cell types and longitudinal parallel structural features of spinal cord tissues remains a significant hurdle. In present study, vascularized spinal cord tissues (VSCT) were engineered using embryonic human spinal cord-derived neural cells and endothelial cells on linear ordered collagen scaffolds (LOCS)...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38536541/bone-marrow-mesenchymal-stem-cell-derived-exosomes-promote-the-recovery-of-spinal-cord-injury-and-inhibit-ferroptosis-by-inactivating-il-17-pathway
#24
JOURNAL ARTICLE
Wen Tang, Kai Zhao, Xiaobo Li, Xiaozhong Zhou, Peigen Liao
Mesenchymal stem cell (MSC)-derived exosomes are considered as alternative to cell therapy in various diseases. This study aimed to understand the effect of bone marrow MSC-derived exosomes (BMMSC-exos) on spinal cord injury (SCI) and to unveil its regulatory mechanism on ferroptosis. Exosomes were isolated from BMMSCs and the uptake of BMMSCs-exos by PC12 cells was determined using PKH67 staining. The effect of BMMSC-exos on SCI in rats was studied by evaluating pathological changes of spinal cord tissues, inflammatory cytokines, and ferroptosis-related proteins...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38535744/how-elite-athletes-with-a-spinal-cord-injury-sweat-during-exercise-an-exploratory-study
#25
JOURNAL ARTICLE
Anneke Hertig-Godeschalk, Claudio Perret
BACKGROUND: Sweat and thermal responses in individuals with spinal cord injury (SCI) are impaired depending on lesion characteristics. This is particularly problematic for athletes and may ultimately lead to reduced performance. This exploratory study investigated the feasibility of field-usable methods to objectively collect data relevant to sweat response in elite athletes with SCI. Differences in sweat response were also evaluated for different athlete characteristics. METHODS: Measurements were performed during exercise and included core temperature (Tc), heart rate, urine specific gravity, fluid intake, sweat rate, and sweat electrolyte concentration...
March 14, 2024: Sports
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#26
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535002/the-impact-of-magnetic-resonance-imaging-findings-in-predicting-neurological-status-pre-and-post-treatment-of-spinal-dural-arteriovenous-fistulas-a-22-year-experience-in-a-neurovascular-and-spine-center
#27
JOURNAL ARTICLE
Andreas Filis, Kay Engellandt, Sergio M F Romualdo, Ibrahim El-Battrawy, Dino Podlesek, Tareq A Juratli, Ilker Y Eyüpoglu, Mido Max Hijazi
BACKGROUND: Successful treatment of spinal dural arteriovenous fistulas (SDAVF) requires prompt diagnosis with definitive fistula localization and non-delayed treatment. Magnetic resonance imaging (MRI) is used for the screening and follow-up of SDAVF, although the value of MRI signs such as myelopathy and flow voids is controversial. Therefore, we investigated the predictive value of MRI signs pre- and post-treatment and their correlation with the neurological status of SDAVF patients...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534998/deep-learning-based-prediction-model-for-gait-recovery-after-a-spinal-cord-injury
#28
JOURNAL ARTICLE
Hyun-Joon Yoo, Kwang-Sig Lee, Bummo Koo, Chan-Woo Yong, Chae-Won Kim
Predicting gait recovery after a spinal cord injury (SCI) during an acute rehabilitation phase is important for planning rehabilitation strategies. However, few studies have been conducted on this topic to date. In this study, we developed a deep learning-based prediction model for gait recovery after SCI upon discharge from an acute rehabilitation facility. Data were collected from 405 patients with acute SCI admitted to the acute rehabilitation facility of Korea University Anam Hospital between June 2008 and December 2022...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534973/the-role-of-oxidative-stress-in-tb-meningitis-and-therapeutic-options
#29
REVIEW
John Dawi, Aishvaryaa Shree Mohan, Yura Misakyan, Scarlet Affa, Edgar Gonzalez, Karim Hajjar, David Nikoghosyan, Sabrina Fardeheb, Christopher Tuohino, Vishwanath Venketaraman
Meningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the central nervous system involves disruptions in the blood-brain barrier, cellular infiltrations, and structural alterations. The clinical features that differentiate between tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM) are discussed in this review and aid in accurate diagnosis...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534825/physically-and-chemically-crosslinked-hyaluronic-acid-based-hydrogels-differentially-promote-axonal-outgrowth-from-neural-tissue-cultures
#30
JOURNAL ARTICLE
Andrej Bajic, Brittmarie Andersson, Alexander Ossinger, Shima Tavakoli, Oommen P Varghese, Nikos Schizas
Our aim was to investigate axonal outgrowth from different tissue models on soft biomaterials based on hyaluronic acid (HA). We hypothesized that HA-based hydrogels differentially promote axonal outgrowth from different neural tissues. Spinal cord sliced cultures (SCSCs) and dorsal root ganglion cultures (DRGCs) were maintained on a collagen gel, a physically crosslinked HA-based hydrogel (Healon 5® ) and a novel chemically crosslinked HA-based hydrogel, with or without the presence of neurotrophic factors (NF)...
February 25, 2024: Biomimetics
https://read.qxmd.com/read/38534205/meningeal-damage-and-interface-astroglial-scarring-in-the-rat-brain-exposed-to-a-laser-induced-shock-wave-s
#31
JOURNAL ARTICLE
Satoko Kawauchi, Akemi Kono, Yuriko Muramatsu, Grant Hennes, Shuta Seki, Susumu Tominaga, Yasue Haruyama, Yukari Komuta, Izumi Nishidate, Susumu Matsukuma, Yushan Wang, Shunichi Sato
In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), grey-white matter junctions (GM-WM), ventricular wall (VW) and regions surrounding cortical blood vessels, accurately reproducing clinical IAS...
March 27, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38533920/when-will-peer-review-become-a-i-review
#32
EDITORIAL
Karsten Wiechert, Jeffrey C Wang, Jens R Chapman
No abstract text is available yet for this article.
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38533637/improvement-of-lower-urinary-tract-dysfunction-by-a-monoacylglycerol-lipase-inhibitor-in-mice-with-spinal-cord-injury
#33
JOURNAL ARTICLE
Kang Jun Cho, Mamoru Hashimoto, Sergei Karnup, Kanako Matsuoka, Tadanobu Kamijo, Joon Chul Kim, Jun Sung Koh, Naoki Yoshimura
AIMS: Activation of the endocannabinoid system by monoacylglycerol lipase (MAGL) blockade may affect the lower urinary tract function. We investigated the effect of an MAGL inhibitor, MJN110, on neurogenic lower urinary tract dysfunction (LUTD) in the mouse model of spinal cord injury (SCI). METHODS: Female C57BL/6 mice that underwent spinal cord transection at T8-10 level were divided into three groups consisting of (1) vehicle-treated SCI mice, (2) 5 mg/kg, or (3) 10 mg/kg of MJN110-treated SCI mice...
March 27, 2024: Neurourology and Urodynamics
https://read.qxmd.com/read/38533172/bilateral-intertrochanteric-femur-fractures-in-a-paraplegic-patient-a-case-report
#34
Anthony Forrest, Samuel G Eaddy, Zachary W Fulton, Benjamin Boothby
Bilateral intertrochanteric (IT) femur fractures are rare, and appropriate evaluation and treatment can vary depending on concurrent patient comorbidities. Even less has been described for patients with bilateral IT fractures with pre-existing paraplegia. This case report describes the unique case of a 72-year-old paraplegic female who presented with bilateral IT femur fractures due to a wheelchair accident. The patient was treated with single-stage bilateral cephalomedullary nail fixation so she could effectively transfer to and from the wheelchair with less pain and a greater chance of fracture union...
February 2024: Curēus
https://read.qxmd.com/read/38532869/clinical-and-functional-evaluation-of-wrists-and-hands-of-spinal-cord-injured-patients
#35
JOURNAL ARTICLE
Cíntia Kelly Bittar, Isabela Ferreira Perucci, Danillo Nagel Signorini, Mariana Buratti Mascarenhas, Orcizo Francisco Silvestre, Alberto Cliquet
INTRODUCTION: The inability of the spinal cord to propagate sensory and motor stimuli as a result of the disruption of the nerve tracts is called spinal cord injury. OBJECTIVE: This study analyzes clinically and radiologically the hands and wrists of spinal cord injured patients, evaluating their motor and sensitive functionality, in order to determine if these patients are more likely to develop degenerative alterations. METHODS: 14 patients (8 paraplegics and 6 tetraplegics) were evaluated, undergoing anamnesis and clinical examination - a scale of muscular strength (MRC - Medical Research Council) and the amplitude measurement of the movement with a manual goniometer (ROM), were used for objective evaluation - and x-ray exams...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532862/orthostatic-support-in-paraplegic-and-amputee-patients-a-controlled-trial
#36
JOURNAL ARTICLE
Gisele Harumi Hotta, Débora Pinheiro Aguiar, Gabriella Coelho Vieira de Melo Alves, Liana Praça Oliveira, Marie Aquino Melo de Leopoldino, Jefferson Pacheco Amaral Fortes, Francisco Carlos de Mattos Brito Oliveira, Francisco Fleury Uchoa Santos
INTRODUCTION: Functional incapacity caused by physical alterations leads to significant limitations in daily activities and has a major impact on the return of people with disabilities to the social space and the workplace. This calls for an evaluation of the long-term influence of the use of a device specially developed for orthostatic posture on the physiological, biomechanical and functional parameters of amputees and spinal cord patients. OBJECTIVE: The objective was evaluate the effect of postural support device use on function, pain, and biomechanical and cardiologic parameters in spinal cord injury and amputees patients compared to a control group...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532704/causes-of-intraoperative-neuromonitoring-events-in-adult-spine-deformity-surgery-a-systematic-review
#37
REVIEW
Chloe Cottone, David Kim, Christopher Lucasti, Maxwell M Scott, Benjamin C Graham, Nell Aronoff, Bilal Hasanspahic, David Kowalski, Justin Bird, Dil Patel
STUDY DESIGN: Systematic review. OBJECTIVES: Intraoperative neuromonitoring (IOMN) has become a standard practice in the detection and prevention of nerve damage and postoperative deficit. While multicenter studies have addressed this inquiry, there have been no systematic reviews to date. This systematic review identifies the leading causes of IONM alerts during adult spinal deformity (ASD) surgeries. METHODS: Following PRISMA guidelines, a literature search was performed in PubMed and Embase...
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38532182/a-pig-model-of-symptomatic-spinal-epidural-hematoma
#38
JOURNAL ARTICLE
Jiasheng Chen, Haozheng Li, Shengxin Zeng, Hua Zhou, Xiao Liu, Panpan Hu, Xiaoguang Liu, Zhongjun Liu, Feng Wei, Zihe Li
PURPOSE: The purpose of this study was to establish an animal model capable of simulating the development and decompression process of symptomatic spinal epidural hematoma (SSEH). METHODS: A total of 16 male Bama miniature pigs were included in this study and randomly allocated into four groups: Group A (4 h 20 mmHg hematoma compression), Group B (4 h 24 mmHg hematoma compression), Group C (4 h 28 mmHg hematoma compression), and Group Sham (control)...
March 27, 2024: European Spine Journal
https://read.qxmd.com/read/38530873/functional-polyphenol-based-nanoparticles-boosted-the-neuroprotective-effect-of-riluzole-for-acute-spinal-cord-injury
#39
JOURNAL ARTICLE
Taoyang Yuan, Tianyou Wang, Jianhua Zhang, Feng Ye, Zhipeng Gu, Yiwen Li, Jianguo Xu
Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole to enhance the neuroprotective effects...
March 26, 2024: Biomacromolecules
https://read.qxmd.com/read/38530570/modulation-of-inflammatory-responses-to-enhance-nerve-recovery-after-spinal-cord-injury
#40
EDITORIAL
Young-Kwon Seo
Inflammation can occur at the wound site, and immune cells are necessary to trigger wound healing and tissue regeneration after injury. It is partly initiated by the rapid migration of immune cells such as neutrophils, inflammatory monocytes, and macrophages after spinal cord injury (SCI). Secondary inflammation can increase the wound area; thus, the function of tissues below the injury levels. Monocytes can differentiate into macrophages, and the macrophage phenotype can change from a pro-inflammatory phenotype to an anti-inflammatory phenotype...
March 26, 2024: Tissue Engineering and Regenerative Medicine
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