keyword
MENU ▼
Read by QxMD icon Read
search

Spinal injury

keyword
https://www.readbyqxmd.com/read/29908137/personality-high-risk-behaviors-and-elevated-risk-of-unintentional-deaths-related-to-drug-poisoning-among-individuals-with-spinal-cord-injury
#1
James S Krause, Yue Cao, Nicole D DiPiro, Emma Cuddy
OBJECTIVE: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI). DESIGN: Prospective cohort study. SETTING: Large specialty hospital in the Southeastern United States. PARTICIPANTS: Two cohorts of SCI participants, totaling 3070 adults (>18 years old) with chronic (>1 year) traumatic SCI...
June 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29907375/fndc5-expression-in-purkinje-neurons-of-adult-male-rats-with-acute-spinal-cord-injury-following-treatment-with-methylprednisolone
#2
Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleimani
Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Recently, the expression of FNDC5 was reported in cerebellar Purkinje cells as a possible neuroprotective agent. In the present study, we considered the expression of FNDC5 in Purkinje cells following SCI with and without MP administration in adult rats with SCI...
May 7, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29907107/complete-abdominal-wound-and-anastomotic-leak-with-diffuse-peritonitis-closure-achieved-by-an-abdominal-vacuum-sealing-drainage-in-a-critical-ill-patient-a-case-report
#3
Yusuke Fujii, Yoshitsugu Tajima, Shunsuke Kaji, Takashi Kishi, Yoshiko Miyazaki, Takahito Taniura, Noriyuki Hirahara
BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound...
June 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29906337/retained-differentiation-capacity-of-human-skeletal-muscle-satellite-cells-from-spinal-cord-injured-individuals
#4
Mladen Savikj, Maxwell A Ruby, Emil Kostovski, Per O Iversen, Juleen R Zierath, Anna Krook, Ulrika Widegren
Despite the well-known role of satellite cells in skeletal muscle plasticity, the effect of spinal cord injury on their function in humans remains unknown. We determined whether spinal cord injury affects the intrinsic ability of satellite cells to differentiate and produce metabolically healthy myotubes. We obtained vastus lateralis biopsies from eight spinal cord-injured and six able-bodied individuals. Satellite cells were isolated, grown and differentiated in vitro. Gene expression was measured by quantitative PCR...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905973/effects-of-teriparatide-and-vibration-on-bone-mass-and-bone-strength-in-people-with-bone-loss-and-spinal-cord-injury-a-randomized-controlled-trial
#5
W Brent Edwards, Narina Simonian, Ifaz T Haider, Alan S Anschel, David Chen, Keith E Gordon, Elaine K Gregory, Ki H Kim, Ramadevi Parachuri, Karen L Troy, Thomas J Schnitzer
Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either: teriparatide 20 µg/day plus sham vibration 10 min/day (n = 20), placebo plus vibration 10 min/day (n = 20), or teriparatide 20 µg/day plus vibration 10 min/day (n = 21). Patients were evaluated for 12 months; those who completed were given the opportunity to participate in an open-label extension where all participants (n = 25) received teriparatide 20 µg/day for an additional 12 months and had the optional use of vibration (10 min/day)...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905916/epidemiological-trends-of-traumatic-brain-and-spinal-cord-injury-in-puerto-rico-from-november-10th-2006-through-may-24th-2011
#6
Ricardo H Brau, Yaritza Acevedo-Salas, Katya Giovannetti
OBJECTIVE: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today. METHODS: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Quantitative variables were expressed as means and averages (plus/minus standard deviation); bivariate cross-tabulation and multiple regression analyses were employed to identify risk factors and compare epidemiological patterns of injury related variables...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905897/patterns-of-injury-and-outcomes-in-the-elderly-patient-with-rib-fractures-a-multicenter-observational-study
#7
Mark G Van Vledder, Vicky Kwakernaak, Tjebbe Hagenaars, Esther M M Van Lieshout, Michiel H J Verhofstad
BACKGROUND: High rates of pneumonia and death have been reported among elderly patients with rib fractures. This study aims to identify patterns of injury and risk factors for pneumonia and death in elderly patients with rib fractures. METHODS: A retrospective multicenter observational study was performed using data registered in the national trauma registry between 2008 and 2015 in the South West Netherlands Trauma region. Data regarding demographics, mechanism of injury, pulmonary and cardiovascular history, pattern of extra-thoracic and intrathoracic injuries, ICU admission, length of stay, and morbidity and mortality following admission were collected...
June 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29905521/contrast-enhanced-ultrasound-to-visualize-hemodynamic-changes-after-rodent-spinal-cord-injury
#8
Zin Z Khaing, Lindsay N Cates, Dane M DeWees, Alexander Hannah, Pierre Mourad, Matthew Bruce, Christoph P Hofstetter
OBJECTIVE Traumatic spinal cord injury (tSCI) causes an almost complete loss of blood flow at the site of injury (primary injury) as well as significant hypoperfusion in the penumbra of the injury. Hypoperfusion in the penumbra progresses after injury to the spinal cord and is likely to be a major contributor to progressive cell death of spinal cord tissue that was initially viable (secondary injury). Neuroprotective treatment strategies seek to limit secondary injury. Clinical monitoring of the temporal and spatial patterns of blood flow within the contused spinal cord is currently not feasible...
June 15, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29905040/-promotion-of-transplanted-collagen-scaffolds-combined-with-brain-derived-neurotrophic-factor-for-axonal-regeneration-and-motor-function-recovery-in-rats-after-transected-spinal-cord-injury
#9
Xi Chen, Yongheng Fan, Zhifeng Xiao, Xing Li, Bin Yang, Yannan Zhao, Xianglin Hou, Sufang Han, Jianwu Dai
Objective: To evaluate the effect of the combination of collagen scaffold and brain-derived neurotrophic factor (BDNF) on the repair of transected spinal cord injury in rats. Methods: Thirty-two Sprague-Dawley rats were randomly divided into 4 groups: group A (sham operation group), T 9 , T 10 segments of the spinal cord was only exposed; group B, 4-mm T 9 , T 10 segments of the spinal cord were resected; group C, 4-mm T 9 , T 10 segments of the spinal cord were resected and linear ordered collagen scaffolds (LOCS) with corresponding length was transplanted into lesion site; group D, 4-mm T 9 , T 10 segments of the spinal cord were resected and LOCS with collagen binding domain (CBD)-BDNF was transplanted into lesion site...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905039/-review-of-the-regeneration-mechanism-of-complete-spinal-cord-injury
#10
Jiayin Li, Xing Li, Zhifeng Xiao, Jianwu Dai
Spinal cord injury (SCI), especially the complete SCI, usually results in complete paralysis below the level of the injury and seriously affects the patient's quality of life. SCI repair is still a worldwide medical problem. In the last twenty years, Professor DAI Jianwu and his team pioneered complete SCI model by removing spinal tissue with varied lengths in rodents, canine, and non-human primates to verify therapeutic effect of different repair strategies. Moreover, they also started the first clinical study of functional collagen scaffold on patients with acute complete SCI on January 16th, 2015...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904952/baicalin-effects-on-rats-with-spinal-cord-injury-by-anti-inflammatory-and-regulating-the-serum-metabolic-disorder
#11
Shufeng Kang, Shizhao Liu, Hongzhu Li, Dapeng Wang, Xiangbei Qi
Baicalin had neuroprotective effects on inhibiting neuronal cell apoptosis induced by spinal cord ischemic injury. This study aimed to explore the protective effects of Baicalin on rats with spinal cord injury (SCI) and its mechanism of action. The recovery of spinal cord nerve function in rats was evaluated by the Basso, Beattie, and Bresnahan (BBB) score and the combine behavioral score (CBS). The expressions of cytokines tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by the enzyme-linked immunosorbent assay method...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904397/thymoquinone-reduces-spinal-cord-injury-by-inhibiting-inflammatory-response-oxidative-stress-and-apoptosis-via-ppar-%C3%AE-and-pi3k-akt-pathways
#12
Yinming Chen, Benlong Wang, Hai Zhao
The present study used a mild contusion injury in rat spinal cord to determine that thymoquinone reduces inflammatory response, oxidative stress and apoptosis in a spinal cord injury (SCI) rat model and to demonstrate its possible molecular mechanisms. The rats in the thymoquinone group received 30 mg/kg thymoquinone once daily by intragastric administration from 3 weeks after surgery. Hematoxylin and eosin staining, Basso, Beattie and Bresnahan (BBB) scale and tissue water content detection were used in the present study to analyze the effect of thymoquinone on SCI...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904191/treatment-patterns-of-in-patient-spasticity-medication-use-after-traumatic-spinal-cord-injury-a-prospective-cohort-study
#13
Kaila A Holtz, Elena Szefer, Vanessa K Noonan, Brian K Kwon, Patricia B Mills
STUDY DESIGN: Prospective cohort study using the Rick Hansen SCI Registry (RHSCIR) and retrospective medical chart review. OBJECTIVE: To describe treatment patterns of in-patient anti-spasticity medication use following traumatic spinal cord injury (SCI) in acute and rehabilitation hospital settings in British Columbia, Canada. SETTING: Quaternary trauma center, rehabilitation center. METHODS: Individuals with traumatic SCI between 2005 and 2014 enrolled in the Vancouver RHSCIR site (N = 917) were eligible for inclusion...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29904190/the-childbearing-experience-of-women-with-spinal-cord-injury-in-iran-a-phenomenological-study
#14
Zahra Khazaeipour, Alireza Nikbakht-Nasrabadi, Nooredin Mohammadi, Alireza Salehi-Nejad, Maryam Shabany
STUDY DESIGN: This was a qualitative study conducted using an interpretative phenomenological approach. OBJECTIVES: This study investigated the experience of pregnancy and childbirth in women with spinal cord injury (SCI). SETTING: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. METHODS: The data were collected using telecommunication and face-to-face semi-structured interviews with eight women with SCI...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29904189/mitigation-of-radiation-myelopathy-and-reduction-of-microglial-infiltration-by-ramipril-ace-inhibitor
#15
Mariano G Clausi, Alexander M Stessin, Stella E Tsirka, Samuel Ryu
STUDY DESIGN: Experimental study. OBJECTIVES: To evaluate the efficacy of Angiotensin-converting enzyme inhibitor Ramipril, as a mitigator of radiation-induced spinal cord injury. SETTING: Stony Brook University, Stony Brook, NY, USA. METHODS: Total of 22 rats were irradiated with single doses of 23.6-33 Gy at the C4-T2 spinal levels. After irradiation, the rats were randomized to the radiation only control group and the Ramipril-treated (radiation + Ramipril) experimental group...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29904188/a-mapping-review-of-randomized-controlled-trials-in-the-spinal-cord-injury-research-literature
#16
REVIEW
Amanda McIntyre, Brooke Benton, Shannon Janzen, Jerome Iruthayarajah, Joshua Wiener, Janice J Eng, Robert Teasell
STUDY DESIGN: Mapping Review. OBJECTIVE: The objective of this study was to map out and characterize the quantity and quality of all published spinal cord injury (SCI) randomized controlled trials (RCTs) with respect to number, sample size, and methodological quality between January 1970 and December 2016. SETTING: Not applicable. METHODS: A literature search of multiple research databases was conducted. Studies adhering to the following criteria were included: the research design was an RCT; written in English; participants were >18 years; and the sample was >50% SCI...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29902901/-effects-of-emodin-on-oxidative-stress-and-inflammatory-response-in-rats-with-acute-spinal-cord-injury
#17
Huan-Huan Zeng, Ying-Ru Huang, Zi-Jian Li, Yi Wang, Song Zhang
This paper was aimed to investigate the effects of emodin on oxidative stress and inflammatory response in rats with acute spinal cord injury(SCI), and to explore the protective mechanism of emodin on neurons after SCI. Rat SCI models were established using a modified Allen's method. One hundred and ninety five Sprague-Dawley rats were randomly divded into sham (group A), model (group B), emodin group of 20 mg·kg⁻¹(group C), emodin group of 40 mg·kg⁻¹(group D), emodin group of 80 mg·kg⁻¹(group E)...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902472/home-based-exercise-enhances-health-related-quality-of-life-in-persons-with-spinal-cord-injury-a-randomized-controlled-trial
#18
Tom E Nightingale, Peter C Rouse, Jean-Philippe Walhin, Dylan Thompson, James L J Bilzon
OBJECTIVE: To assess the influence of a home-based exercise intervention on indices of health-related quality of life (HRQOL) in persons with spinal cord injury (SCI). DESIGN: This was a randomized controlled trial (HOMEX-SCI; ISRCTN57096451). After baseline laboratory testing and a week of free-living physical activity monitoring, eligible participants were randomly assigned (2:1 allocation ratio) to a home-based moderate-intensity upper-body exercise intervention (INT, n = 13), or a lifestyle maintenance control group (CON, n = 8), for 6 weeks...
June 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29902393/administration-and-performance-on-the-spinal-cord-injury-medicine-certification-examination-over-a-10-year-period
#19
Sunil Sabharwal, Anthony E Chiodo, Mikaela M Raddatz
CONTEXT/OBJECTIVE: The examination for Spinal Cord Injury (SCI) Medicine subspecialty certification has been administered since 1998, but published information about exam performance or administration is limited. DESIGN: Retrospective review Setting/Participants: We examined de-identified information from the American Board of Physical Medicine and Rehabilitation (ABPMR) database for characteristics and performance of candidates (n = 566) who completed the SCI Medicine Examination over a 10-year period (2005-2014), during which the exam outline and passing standard remained consistent...
June 14, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29901416/intravenous-infusion-of-mesenchymal-stem-cells-alters-motor-cortex-gene-expression-in-a-rat-model-of-acute-spinal-cord-injury
#20
Tsutomu Oshigiri, Toru Sasaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Masahito Nakazaki, Shinichi Oka, Tomonori Morita, Ryosuke Hirota, Mitsunori Yoshimoto, Toshihiko Yamashita, Kazue Hashimoto-Torii, Osamu Honmou
Recent evidence has demonstrated that remote responses in the brain can be induced after spinal cord injury (SCI), as well as local responses in the injured spinal cord. Intravenous infusion of mesenchymal stem cells (MSCs) has been shown to provide functional improvements in SCI through local therapeutic mechanisms that provide neuroprotection, stabilization of the blood-spinal cord barrier, remyelination, and axonal sprouting. In the present study, we examined the brain response that might be associated with the functional improvements induced by the infused MSCs after SCI...
June 14, 2018: Journal of Neurotrauma
keyword
keyword
5059
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"