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https://www.readbyqxmd.com/read/29677029/kindlin-1-regulates-astrocyte-activation-and-pain-sensitivity-in-rats-with-neuropathic-pain
#1
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
BACKGROUND AND OBJECTIVES: Astrocyte activation has been implicated in the pathogenesis of neuropathic pain, but the involvement of kindlin-1 in astrocyte activation and neuropathic pain has not yet been illustrated. Using a chronic constriction injury (CCI) rat model of neuropathic pain, we investigated the expression levels of kindlin-1 during neuropathic pain and the influences of kindlin-1 on regulating pain sensitivity. METHODS: Neuropathic pain was induced in rats by CCI of the sciatic nerve...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29676679/principles-of-system-design-not-realized-for-pediatric-craniospinal-trauma-care-in-the-united-states
#2
Joseph Piatt
OBJECTIVE An implicit expectation of the pioneers of trauma system design was that high clinical volume at select centers could lead to superior outcomes. There has been little study of the regionalization of pediatric craniospinal trauma care, and whether it continues to trend in the direction of regionalization is unknown. The motivating hypothesis for this study was that trauma system design in the United States is proceeding on a rational basis, producing hospital caseloads that are increasing over time and, because of geographic siting appropriate to the needs of catchment areas, in an increasingly uniform manner...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29676669/sequential-neurological-improvements-after-conservative-treatment-in-patients-with-complete-motor-paralysis-caused-by-cervical-spinal-cord-injury-without-bone-and-disc-injury
#3
Eiji Mori, Takayoshi Ueta, Takeshi Maeda, Ryousuke Ideta, Itaru Yugué, Osamu Kawano, Keiichiro Shiba
OBJECTIVE This study investigated neurological improvements after conservative treatment in patients with complete motor paralysis caused by acute cervical spinal cord injury (SCI) without bone and disc injury. METHODS This study was retrospective. The authors evaluated neurological outcomes after conservative treatment of 62 patients with complete motor paralysis caused by cervical SCI without bone and disc injury within 72 hours after trauma. The sequential changes in their American Spinal Injury Association Impairment Scale (AIS) grades were reviewed at follow-up 24-72 hours, 1 week, and 1, 3, and 6 months after treatment...
April 20, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29675749/evaluation-of-severe-and-fatal-injuries-in-extreme-and-contact-sports-an-international-multicenter-analysis
#4
Christian D Weber, Klemens Horst, Anthony R Nguyen, Rolf Lefering, Hans-Christoph Pape, Frank Hildebrand
PURPOSE: The participation in extreme and contact sports has grown internationally, despite the significant risk for major and multiple injuries. We conducted this multicenter study to evaluate sport-specific injury patterns and mechanisms, to characterize individuals at risk and to identify possible approaches for prevention. METHODS: We compared demographic data, severity and patterns of injuries; and the pre- and in-hospital management from an international population-based prospective trauma database (TraumaRegister DGU®)...
April 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29674624/brain-and-spinal-cord-injury-repair-by-implantation-of-human-neural-progenitor-cells-seeded-onto-polymer-scaffolds
#5
Jeong Eun Shin, Kwangsoo Jung, Miri Kim, Kyujin Hwang, Haejin Lee, Il-Sun Kim, Bae Hwan Lee, Il-Shin Lee, Kook In Park
Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29673859/orofacial-neuropathic-pain-reduces-spontaneous-burrowing-behavior-in-rats
#6
K Deseure, G Hans
It was recently reported that spontaneous burrowing behavior is decreased after tibial nerve transection, spinal nerve transection and partial sciatic nerve ligation. It was proposed that spontaneous burrowing could be used as a measure of the impact of neuropathic pain after peripheral nerve injury. It has remained unclear whether the reduction in burrowing behavior is caused directly by pain or hypersensitivity in the affected limbs, making it more difficult to perform burrowing, or by a pain induced decrease in the general wellbeing, thus reducing the motivation to burrow...
April 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29672351/femoral-artery-blood-flow-and-microcirculatory-perfusion-during-acute-low-level-functional-electrical-stimulation-in-spinal-cord-injury
#7
Thomas J Barton, David A Low, Thomas W J Janssen, Maurits Sloots, Christof A J Smit, Dick H J Thijssen
OBJECTIVE: Functional electrical stimulation (FES) may help to reduce the risk of developing macro- and microvascular complications in people with SCI. Low-intensity FES has significant clinical potential since this can be applied continuously throughout the day. This study examines the acute effects of low intensity FES using wearable clothing garment on vascular blood flow and oxygen consumption in people with SCI. DESIGN: Cross-sectional observation study METHODS: Eight participants with a motor complete SCI received 4x3 minutes of unilateral FES to the gluteal and hamstring muscles...
April 19, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29672224/nocturnal-swallowing-and-arousal-threshold-in-individuals-with-chronic-spinal-cord-injury
#8
Aliza Rizwan, Abdulghani Sankari, Amy T Bascom, Sarah Vaughan, M Safwan Badr
Respiratory complications are potential causes of death in patients with spinal cord injury (SCI). Nocturnal swallowing could be related to transient arousals, and lead to fragmented sleep in SCI patients. However, the impact of nocturnal swallowing on breathing and sleep physiology in SCI is unknown. The objectives of this study were (1) to determine whether nocturnal swallowing is more common in SCI than in able-bodied subjects, (2) to determine the role of nocturnal swallowing on arousal threshold in SCI individuals with sleep-disordered breathing (SDB), (3) to determine the effect of CPAP treatment on nocturnal swallowing...
April 19, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29672077/use-and-psychometric-properties-of-the-flourishing-scale-among-adults-with-spinal-cord-injury
#9
Marisa J Perera, Michelle A Meade, Lisa DiPonio
PURPOSE/OBJECTIVE: Despite increased interest in the topic of resilience in rehabilitation, there has been no psychometric investigation of the Flourishing Scale (FS) in a sample of adults with spinal cord injury (SCI). The present study examined the reliability, convergent validity, and factor structure of the FS. Research Method/Design: Data for this project were extracted from a larger study on happiness and quality of life after SCI. For this study, information was collected using a cross-sectional mail survey design of adults with SCI...
April 19, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29671236/picroside-ii-attenuates-cci-induced-neuropathic-pain-in-rats-by-inhibiting-spinal-reactive-astrocyte-mediated-neuroinflammation-through-the-nf-%C3%AE%C2%BAb-pathway
#10
Xiaolian Nong, Yuyan Lan
Reactive astrocyte-mediated neuroinflammatory responses in the spinal dorsal horn have been reported to play a pivotal role in pathological pain. Chronic constriction injury (CCI) enhances the activation of nuclear factor kappa B (NF-κB), which is involved in neuropathic pain (NP). Picroside II (PII), a major active component of Picrorhiza scrophulariiflora, has been investigated for its anti-oxidative, anti-inflammatory, and anti-apoptotic activities. Here, we explored the analgesic effects of PII on a model of CCI-induced NP and investigated the levels of the GFAP protein and the mRNA and protein levels of pro-inflammatory cytokines in the spinal cord, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)...
April 18, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29671028/biochemical-profiling-of-rat-embryonic-stem-cells-grown-on-electrospun-polyester-fibers-using-synchrotron-infrared-microspectroscopy
#11
Ernesto Doncel-Pérez, Gary Ellis, Christophe Sandt, Peter S Shuttleworth, Agatha Bastida, Julia Revuelta, Eduardo García-Junceda, Alfonso Fernández-Mayoralas, Leoncio Garrido
Therapeutic options for spinal cord injuries are severely limited; current treatments only offer symptomatic relief and rehabilitation focused on educating the individual on how to adapt to their new situation to make best possible use of their remaining function. Thus, new approaches are needed, and interest in the development of effective strategies to promote the repair of neural tracts in the central nervous system inspired us to prepare functional and highly anisotropic polymer scaffolds. In this work, an initial assessment of the behavior of rat neural progenitor cells (NPCs) seeded on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) fiber scaffolds using synchrotron-based infrared microspectroscopy (SIRMS) is described...
April 18, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29670039/a-wearable-body-controlling-device-for-application-of-functional-electrical-stimulation
#12
Nazita Taghavi, Greg R Luecke, Nicholas D Jeffery
In this research, we describe a new balancing device used to stabilize the rear quarters of a patient dog with spinal cord injuries. Our approach uses inertial measurement sensing and direct leg actuation to lay a foundation for eventual muscle control by means of direct functional electrical stimulation (FES). During this phase of development, we designed and built a mechanical test-bed to develop the control and stimulation algorithms before we use the device on our animal subjects. We designed the bionic test-bed to mimic the typical walking gait of a dog and use it to develop and test the functionality of the balancing device for stabilization of patient dogs with hindquarter paralysis...
April 18, 2018: Sensors
https://www.readbyqxmd.com/read/29668610/a-term-vaginal-delivery-by-a-patient-with-traumatic-tetraplegia-a-case-report
#13
Changfang Yao, Yongjuan Xu, Li Dai, Yan Lv, Xiaoli Xu, Wenfeng Ye
RATIONALE: About 60,0000 people are involved in traffic accident each year in China and spinal cord injury (SCI) often occurs. Pregnant women with paraplegia is rare, and they face higher risk during pregnancy and childbirth. PATIENT CONCERNS: We report a case of a 35-year-old patient with SCI, who had vaginal forceps delivery at 38 weeks and 5 days of gestation. DIAGNOSES: The patient was diagnosed with term pregnancy with traumatic tetraplegia...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668389/stepping-responses-to-treadmill-perturbations-vary-with-severity-of-motor-deficits-in-human-sci
#14
Virginia Way Tong Chu, T George Hornby, Brian D Schmit
In this study, we investigated the responses to tread perturbations during human stepping on a treadmill. Our approach was to test the effects of perturbations to a single leg using a split-belt treadmill in healthy participants and in participants with varying severity of spinal cord injury (SCI). We recruited 11 people with incomplete SCI and 5 noninjured participants. As participants walked on an instrumented treadmill, the belt on one side was stopped or accelerated briefly during mid to late stance. A majority of participants initiated an unnecessary swing when the treadmill was stopped in mid stance, although the likelihood of initiating a step was decreased in participants with more severe SCI...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29668375/evaluation-of-pelvis-postural-systems-in-spinal-cord-injury-patients-outcome-research
#15
Serena Dattoli, Mariele Colucci, Maria Grazia Soave, Rita De Santis, Leandro Segaletti, Claudia Corsi, Marco Tofani, Donatella Valente, Giovanni Galeoto
OBJECTIVES: Compare three commercially available postural systems to determine the best for treatment of patients suffering from spinal cord injury lesion below the cervical spine. DESIGN: Outcome Research. SETTING: Ambulatory. PARTICIPANTS: Thirteen patients were recruited for this study between March 2016 and July 2016 from the Occupational Therapy clinic of "Policlinico Umberto I" hospital in Rome and Occupational Therapy of "CPO" hospital in Ostia...
April 18, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29667905/essential-role-of-mohawk-for-tenogenic-tissue-homeostasis-including-spinal-disc-and-periodontal-ligament
#16
Ryo Nakamichi, Kensuke Kataoka, Hiroshi Asahara
Tendons and ligaments play essential roles in connecting muscle and bone and stabilizing the connections between bones. The damage to tendons and ligaments caused by aging, injury, and arthritis induces the dysfunction of the musculoskeletal system and reduces the quality of life. Current therapy for damaged tendons and ligaments depends on self-repair; however, it is difficult to reconstruct normal tissue. Regeneration therapy for tendons and ligaments has not been achieved, partly because the mechanism, cell biology, and pathophysiology of tendon and ligament development remain unclear...
April 18, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29667522/pressure-distribution-analysis-in-three-wheelchairs-cushions-of-subjects-with-spinal-cord-injury
#17
Paulo Vinicius Braga Mendes, Luma Carolina Câmara Gradim, Natália Sanches Silva, Ana Luiza Caltabiano Allegretti, Débora Couto De Melo Carrijo, Daniel Marinho Cezar da Cruz
PURPOSE: Pressure injuries are a complication due to spinal cord injury. The objective of the study is to compare the pressure distribution in the wheelchair seat of subjects with spinal cord injury using 3 pads (Roho® , Varilite® and Varilite® ). METHODS: Pressure analysis was performed on 10 participants in two situations: (a) the participant sitting in static posture and (b) with the wheelchair being used for locomotion. RESULTS: In the static position: Jay® showed the best rates for average pressure and also the contact area, the Roho® had the lowest average for the peak pressure...
April 18, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29667507/effect-of-inspiratory-muscle-training-imt-on-aerobic-capacity-respiratory-muscle-strength-and-rate-of-perceived-exertion-in-paraplegics
#18
Sonali Soumyashree, Jaskirat Kaur
OBJECTIVES: The purpose is to study the effect of inspiratory muscle training on aerobic capacity, respiratory muscle strength and rate of perceived exertion in paraplegics. STUDY DESIGN: Randomized controlled trial. SETTINGS: Rehabilitation department in Indian Spinal Injuries Centre, New Delhi. PARTICIPANTS: A sample of 30 paraplegics (T1-T12) were randomly allocated into two groups: inspiratory muscle training (IMT) group and control group...
April 18, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29667192/how-does-spinal-cord-injury-lead-to-obstructive-sleep-apnea
#19
D D Fuller
No abstract text is available yet for this article.
April 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29666666/early-factors-associated-with-the-development-of-chronic-pain-in-trauma-patients
#20
Raoul Daoust, Jean Paquet, Lynne Moore, Marcel Émond, Sophie Gosselin, Gilles Lavigne, Manon Choinière, Aline Boulanger, Jean-Marc Mac-Thiong, Jean-Marc Chauny
Objective: To identify factors, available at the time of trauma admission, associated with the development of chronic pain to allow testing of preventive approaches. Methods: In a retrospective observational cohort study, we included all patients ≥ 18 years old admitted for injury in 57 adult trauma centers in the province of Quebec (Canada) between 2004 and 2014. Chronic pain was defined as follows: treated in a chronic pain clinic, diagnosed with chronic pain, or received at least 2 prescriptions of chronic pain medications 3 to 12 months postinjury...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
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