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https://www.readbyqxmd.com/read/28730505/stool-based-testing-for-colorectal-cancer-an-overview-of-available-evidence
#1
REVIEW
Kevin M Rank, Aasma Shaukat
PURPOSE OF REVIEW: The goal of this review is to summarize stool-based testing for colorectal cancer (CRC). The key questions answered in this review were the advantages and limitations of each available stool-based test for CRC and to examine their comparative efficacy. RECENT FINDINGS: Guaiac-based fecal occult blood testing (gFOBT) is no longer a relevant test for CRC screening. fecal immunochemical testing (FIT) tests, especially quantitative assays, are clearly a reliable stool-based test...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28721099/sociodemographic-characteristics-of-nonparticipants-in-the-danish-colorectal-cancer-screening-program-a-nationwide-cross-sectional-study
#2
Mette Bach Larsen, Ellen M Mikkelsen, Morten Rasmussen, Lennart Friis-Hansen, Anders U Ovesen, Hans Bjarke Rahr, Berit Andersen
INTRODUCTION: Fecal occult blood tests are recommended for colorectal cancer (CRC) screening in Europe. Recently, the fecal immunochemical test (FIT) has come into use. Sociodemographic differences between participants and nonparticipants may be less pronounced when using FIT as there are no preceding dietary restrictions and only one specimen is required. The aim of this study was to examine the associations between sociodemographic characteristics and nonparticipation for both genders, with special emphasis on those who actively unsubscribe from the program...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28699947/fecal-occult-blood-testing-in-hospitalized-patients-with-upper-gastrointestinal-bleeding
#3
Benji Mathews, Temple Ratcliffe, Raj Sehgal, James Abraham, Bradley Monash
A 47-year-old man with a history of alcohol abuse, cirrhosis, and grade II esophageal varices is admitted for treatment of alcohol withdrawal. He reports having some dark-colored stools a week prior to admission, but his stools since then have been normal in color. A repeat hemoglobin is stable, but a fecal occult blood test is positive. What should be done next?
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28696184/insurance-coverage-for-ct-colonography-screening-impact-on-overall-colorectal-cancer-screening-rates
#4
Maureen A Smith, Jennifer M Weiss, Aaron Potvien, Jessica R Schumacher, Ronald E Gangnon, David H Kim, Lauren A Weeth-Feinstein, Perry J Pickhardt
Purpose To compare overall colorectal cancer (CRC) screening rates for patients who were eligible and due for CRC screening and who were with and without insurance coverage for computed tomographic (CT) colonography for CRC screening. Materials and Methods The institutional review board approved this retrospective cohort study, with a waiver of consent. This study used longitudinal electronic health record data from 2005 through 2010 for patients managed by one of the largest multispecialty physician groups in the United States...
July 11, 2017: Radiology
https://www.readbyqxmd.com/read/28689518/colon-cancer-screening-is-it-time-yet
#5
EDITORIAL
Hadi Bhurgri, Sami Samiullah
The month of March is dedicated to Colon Cancer Awareness. Worldwide, colorectal cancer (CRC) incidence has been on the rise. It is currently the third most common cancer in men (746,000 cases, 10.0% of the total) and the second in women (614,000 cases, 9.2% of the total).1 Arecent meta-analysis reported a 61% risk reduction in CRC incidence with colonoscopy.2 Unlike screening programs for breast and prostate cancers, not only has CRC screening reduced mortality from colon cancer and detected early CRC, it has also decreased the incidence of CRC through detection and removal of pre-cancerous lesions...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28687458/effectiveness-of-screening-modalities-in-colorectal-cancer-a-network-meta-analysis
#6
REVIEW
Jianping Zhang, Zhiyuan Cheng, Yubao Ma, Caili He, Yongbin Lu, Yaxue Zhao, Xiaoyu Chang, Yawei Zhang, Yana Bai, Ning Cheng
The aim of the study was to evaluate on the effectiveness of screening modalities in the prevention of colorectal cancer (CRC) occurrence and deaths. General meta-analysis was performed to produce pooled estimates of the effect of CRC incidence and mortality using a search of PubMed, Web of Science, and the Cochrane Library for eligible studies from January 1992 to March 2016. A network meta-analysis was performed to synthetically compare the effectiveness of 5 frequently used screening modalities. A total of 44 studies with a focus on mortality from CRC using different screening methods were included...
April 4, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28675068/fecal-calprotectin-is-a-strong-predictive-marker-of-relapse-in-chinese-patients-with-crohn-s-disease-a-two-year-prospective-study
#7
Lei Ye, Bi Qin Chen, Shao Dong Wang, Hui Shi, Zhao Yang, Fang Yu Wang
OBJECTIVE: To evaluate the predictive value of fecal calprotectin (FC) for clinical relapse in Chinese patients with quiescent Crohn's disease (CD) and to further investigate the correlation between FC and intestinal inflammation. METHODS: Sixty-two patients with a diagnosis of quiescent CD were consecutively enrolled in this prospective study. Fecal samples were collected and enteroscopy were performed to detect mucosal lesions at the beginning of the study. Patients were followed until the first relapse or by the end of the two-year follow-up...
July 4, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28664503/predictors-of-colorectal-cancer-knowledge-and-screening-among-asian-americans-aged-50-75-years-old
#8
Hee-Soon Juon, Jenny Guo, Jin Kim, Sunmin Lee
Colorectal cancer, the second leading cause of mortality in the USA, can be prevented with colorectal cancer screening. However, many people who should receive the screening do not get screened. To learn more, this study estimated the prevalence of up-to-date colorectal cancer (CRC) screening and examined the relationship between CRC knowledge and screening compliance among Asian Americans living in the Baltimore-Washington Metropolitan area. The study included a cross-sectional sample of 274 Chinese, Korean, and Vietnamese Americans aged 50-75 years old...
June 29, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28660489/novel-approach-to-fecal-occult-blood-testing-by-assay-of-erythrocyte-specific-microrna-markers
#9
Chung Wah Wu, Xiaoming Cao, Calise K Berger, Patrick H Foote, Douglas W Mahoney, Julie A Simonson, Bradley W Anderson, Tracy C Yab, William R Taylor, Lisa A Boardman, John B Kisiel, David A Ahlquist
BACKGROUND: Fecal occult blood testing (FOBT) has historically relied on methods to detect hemoglobin with no fundamental innovations in decades. AIM: To examine microRNA (miRNA) as a new marker class for FOBT. METHODS: Candidate miRNA markers were identified by small RNA sequencing of human whole blood compared to colorectal epithelia. Markers were tested in human blood cell subsets and blood from non-human species. We assessed assay linearity in blood spiking and marker stability in stool over incubation experiments...
August 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28655982/clinical-impact-of-the-immunochemical-fecal-occult-blood-test-for-colorectal-cancer-screening-in-brazil
#10
Cláudio R Teixeira, Michele L Bonotto, Júlio P Lima, Luciana F Figueiredo, Leonardo Conrado, Carlos Frasca
BACKGROUND: Colorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease. METHODS: This population-based study was performed between April 2015 and January 2016 in two gastroenterology referral centers in Southern Brazil. It included 1039 average-risk volunteers aged 50-75 years who were symptom-free for colonic disease...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28626067/the-impact-of-a-population-based-screening-program-on-income-and-immigration-related-disparities-in-colorectal-cancer-screening
#11
Tara Kiran, Richard H Glazier, Rahim Moineddin, Sumei Gu, Andrew S Wilton, Lawrence Paszat
A population-based program promoting the Fecal Occult Blood Test (FOBT) for colorectal cancer screening was introduced in 2008 in Ontario, Canada, where opportunistic screening with colonoscopy had been increasing in frequency. We evaluated the impact of the program on income and immigration-related disparities in screening. We used linked administrative data to calculate colorectal cancer screening rates for eligible Ontarians in each year between 2001/02 (n=2,852,619) and 2013/14 (n=4,139,304). We quantified disparities using an "inequality ratio" of screening rates in the most disadvantaged group relative to the most advantaged group...
June 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28614895/endocuff-assisted-vs-standard-colonoscopy-in-the-fecal-occult-blood-test-based-uk-bowel-cancer-screening-programme-e-cap-study-a-randomized-trial
#12
Rupam Bhattacharyya, Fergus Chedgy, Kesavan Kandiah, Carole Fogg, Bernard Higgins, Ben Haysom-Newport, Lisa Gadeke, Fergus Thursby-Pelham, Richard Ellis, Patrick Goggin, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP colonoscopy. The primary outcome was the number of polyps per patient. Secondary outcomes included the number of adenomas per patient, adenoma and polyp detection rates, and withdrawal times...
June 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28611516/colorectal-cancer-population-screening-programs-worldwide-in-2016-an-update
#13
REVIEW
Mercedes Navarro, Andrea Nicolas, Angel Ferrandez, Angel Lanas
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The incidence and mortality show wide geographical variations. Screening is recommended to reduce both incidence and mortality. However, there are significant differences among studies in implementation strategies and detection. This review aimed to present the results and strategies of different screening programs worldwide. We reviewed the literature on national and international screening programs published in PubMed, on web pages, and in clinical guidelines...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28599341/a-case-of-colonic-adenoma-involving-a-diverticulum-resected-by-a-traction-assisted-endoscopic-submucosal-dissection-technique
#14
Satoki Shichijo, Yasushi Yamasaki, Yoji Takeuchi
A 76-year-old man with positive fecal occult blood tests underwent colonoscopy, which revealed a laterally spreading tumor completely surrounding a diverticulum in the ascending colon. He was referred to our hospital for further examination and treatment. A second colonoscopy revealed that the laterally spreading tumor involved an entire diverticulum in the posterior wall of the ascending colon. This article is protected by copyright. All rights reserved.
June 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28584248/fecal-occult-blood-test-results-of-the-national-colorectal-cancer-screening-program-in-south-korea-2006-2013
#15
John Hoon Rim, Taemi Youk, Jung Gu Kang, Byung Kyu Park, Heon Yung Gee, Jeong-Ho Kim, Jongha Yoo
There has been controversy regarding the clinical utility of fecal occult blood test (FOBT) as a screening tool for colorectal cancer (CRC) in the general population. The purpose of this study was to examine the results of Korea national CRC screening using FOBT from 2006 to 2013 and to evaluate the implementation of the program. We analyzed the results of FOBT, colonoscopy, and the side effects during colonoscopy for the subjects (n = 20,609,909) from the Korea National Health Insurance Cancer Screening database...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515797/circulating-nucleosomes-as-new-blood-based-biomarkers-for-detection-of-colorectal-cancer
#16
Jean-François Rahier, Anne Druez, Laurence Faugeras, Jean-Paul Martinet, Myriam Géhénot, Eléonore Josseaux, Marielle Herzog, Jake Micallef, Fabienne George, Monique Delos, Thierry De Ronde, Abdenor Badaoui, Lionel D'Hondt
BACKGROUND: Colonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure. However, certain limitations exist in most countries including cost and access to the procedure. Moreover, colonoscopy is an invasive technique with risk inherent to the endoscopic procedure. For this reason, alternative screening tests, in particular, fecal occult blood-based tests, have been widely adopted for frontline screening...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28505217/effect-of-combined-patient-decision-aid-and-patient-navigation-vs-usual-care-for-colorectal-cancer-screening-in-a-vulnerable-patient-population-a-randomized-clinical-trial
#17
Daniel S Reuland, Alison T Brenner, Richard Hoffman, Andrew McWilliams, Robert L Rhyne, Christina Getrich, Hazel Tapp, Mark A Weaver, Danelle Callan, Laura Cubillos, Brisa Urquieta de Hernandez, Michael P Pignone
Importance: Colorectal cancer (CRC) screening is underused, especially among vulnerable populations. Decision aids and patient navigation are potentially complementary interventions for improving CRC screening rates, but their combined effect on screening completion is unknown. Objective: To determine the combined effect of a CRC screening decision aid and patient navigation compared with usual care on CRC screening completion. Design, Setting, and Participants: In this randomized clinical trial, data were collected from January 2014 to March 2016 at 2 community health center practices, 1 in North Carolina and 1 in New Mexico, serving vulnerable populations...
July 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28494531/stages-of-adoption-for-fobt-and-colonoscopy-tests-for-colorectal-cancer-screening-in-korea
#18
Nhung Bui Cam, Hana Cho, Yoon Young Lee, Mina Suh, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
Purpose: While colorectal cancer (CRC) is common in Asian countries, screening for CRC is not. Moreover, CRC screening behaviors in Asian populations remain largely unknown. The present study aimed to investigate the stages of adopting CRC screening in Korea according to screening modality. Materials and Methods: Data were obtained from the 2014 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling to investigate cancer screening rates...
May 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28493543/contribution-of-patient-physician-and-environmental-factors-to-demographic-and-health-variation-in-colonoscopy-follow-up-for-abnormal-colorectal-cancer-screening-test-results
#19
Melissa R Partin, Amy A Gravely, James F Burgess, David A Haggstrom, Sarah E Lillie, David B Nelson, Sean M Nugent, Aasma Shaukat, Shahnaz Sultan, Louise C Walter, Diana J Burgess
BACKGROUND: Patient, physician, and environmental factors were identified, and the authors examined the contribution of these factors to demographic and health variation in colonoscopy follow-up after a positive fecal occult blood test/fecal immunochemical test (FOBT/FIT) screening. METHODS: In total, 76,243 FOBT/FIT-positive patients were identified from 120 Veterans Health Administration (VHA) facilities between August 16, 2009 and March 20, 2011 and were followed for 6 months...
May 11, 2017: Cancer
https://www.readbyqxmd.com/read/28490420/testing-the-effectiveness-of-a-primary-care-intervention-to-improve-uptake-of-colorectal-cancer-screening-a-randomized-controlled-trial-protocol
#20
Natalie Dodd, Mariko Leanne Carey, Elise Mansfield, Christopher Oldmeadow
BACKGROUND: Screening for colorectal cancer (CRC) significantly reduces mortality associated with this disease. In Australia, the National Bowel Cancer Screening Program provides regular fecal occult blood tests (FOBT) for those aged 50 to 74 years, however, participation rates in the program have plateaued at 36%. Given low uptake in the National Bowel Cancer Screening Program, it is necessary to explore alternate methods to increase CRC screening rates. Primary care is a promising adjunct setting to test methods to increase CRC screening participation...
May 10, 2017: JMIR Research Protocols
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