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fecal occult blood

Yangming Gong, Peng Peng, Pingping Bao, Weijian Zhong, Yan Shi, Kai Gu, Ying Zheng, Chunxiao Wu, Sanjun Cai, Ye Xu, Jun Sheng, Fan Wu
BACKGROUND: The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes in lifestyle factors. Early detection and treatment guidelines for asymptomatic cases have shown to improve CRC control in developed countries. In response to these challenges, the Shanghai Municipal Government launched a community-based CRC screening program in 2012. MATERIALS AND METHODS: Free initial screening, inclusive of immunochemical fecal occult blood and risk assessment (questionnaire), was provided by community health centers in Shanghai...
March 14, 2018: Oncologist
Cynthia M Mojica, Deborah Parra-Medina, Sally Vernon
INTRODUCTION: Colorectal cancer, the second leading cause of cancer death in the United States, is also among the most preventable cancers. However, Latino men are less likely than non-Latino men to engage in preventive screening. Compared with 60% of non-Latino white men and women, only 42% of Latino men are up to date with colorectal cancer screening guidelines, which may result in diagnosis at advanced disease stages and increased deaths. We evaluated the literature on colorectal cancer screening interventions among Latino men to characterize intervention components effective in increasing colorectal cancer screening...
March 8, 2018: Preventing Chronic Disease
Jessica Lacy Yasuda, Paul A Rufo
A 20-month-old boy presented with a 2-week history of pallor and progressive abdominal distention. Nutritional history revealed long-standing excessive cow milk intake. He was subsequently found to be profoundly iron deficient and hypoproteinemic, with an elevated fecal α-1-antitrypsin level and occult blood positive stool, consistent with protein-losing enteropathy. He was treated with cow milk restriction and oral iron supplements, which resulted in resolution of his edema and laboratory anomalies. While small numbers of previous case reports have described the potential association between excessive cow milk intake and severe iron deficiency and protein-losing enteropathy, this constellation of clinical symptoms is infrequently recognized in clinical practice...
January 2018: Journal of Investigative Medicine High Impact Case Reports
Jérôme Viguier, Jean-François Morère, Lysel Brignoli-Guibaudet, Christine Lhomel, Sébastien Couraud, François Eisinger
BACKGROUND: The aim of EDIFICE surveys is to improve insight into the behavior of the French population with regard to cancer prevention and participation in screening programs. Via the colorectal cancer screening program, all average-risk individuals in the 50-74-year age group are invited every 2 years to do a guaiac-based or, since April 2015, an immunochemical fecal occult blood test. METHODS: The fifth edition of the nationwide observational survey was conducted by phone interviews using the quota method...
March 5, 2018: Current Oncology Reports
Siyu Liu, Mugen Dai, Bin Ye, Zhigang Zhao, Yang Shi, Lirong Peng
RATIONALE: Diaphragmatic Hernia is rare as complication of Colonoscopy. Diaphragmatic hernia as a complication of colonoscopy has been reported only few cases. Additionally, it is often misdiagnosed as other disease by clinicians due to their lack of related knowledge, which delays diagnosis of Diaphragmatic hernia and thus exacerbates the prognosis. PATIENT CONCERNS: We report the case of a 66-year-old man with fecal occult blood. In the case, sudden epigastric pain after colonoscopy owing to diaphragmatic hernia in a left hemidiaphragm...
January 2018: Medicine (Baltimore)
Amit G Singal, Douglas A Corley, Aruna Kamineni, Michael Garcia, Yingye Zheng, Paul V Doria-Rose, Virginia P Quinn, Christopher D Jensen, Jessica Chubak, Jasmin Tiro, Chyke A Doubeni, Nirupa R Ghai, Celette Sugg Skinner, Karen Wernli, Ethan A Halm
OBJECTIVES: Effectiveness of fecal occult blood test (FOBT) for colorectal cancer (CRC) screening depends on annual testing, but little is known about patterns of repeat stool-based screening within different settings. Our study's objective was to characterize screening patterns and identify factors associated with repeat screening among patients who completed an index guaiac FOBT (gFOBT) or fecal immunochemical test (FIT). METHODS: We performed a multi-center retrospective cohort study among people who completed a FOBT between January 2010 and December 2011 to characterize repeat screening patterns over the subsequent 3 years...
February 27, 2018: American Journal of Gastroenterology
Mathieu Pioche, Christell Ganne, Rodica Gincul, Antoine De Leusse, Julien Marsot, Julien Balique, Alain Fond, Michel Bretagnolle, Luc Henry, Yann Billaud, Romain Malezieux, Marie-Georges Lapalus, Christine Chambon-Augoyard, Emilie Del Tedesco, Olivia Scalone, Jean-Charles Montoy, Benoit Russias, Antoine Detry, Frédéric Veniat, Jin Qiu, Pierre-Jean Valette, Annabel Taillandier, Jean-Christophe Saurin, Josiane Tomczyk-Ferrero, Clémentine Gandilhon, Léa Vecchiato, Patricia Soler-Michel, Thierry Ponchon
OBJECTIVE:  Some patients (10 % - 32 %) with a positive guaiac fecal occult blood test (gFOBT) do not undergo the recommended colonoscopy. The aim of this study was to compare video capsule endoscopy (VCE) and computed tomography colonography (CTC) in terms of participation rate and detection outcomes when offered to patients with a positive gFOBT who did not undergo the recommended colonoscopy. METHODS:  An invitation letter offering CTC or VCE was sent to selected patients after randomization...
February 27, 2018: Endoscopy
Manon van der Vlugt, Esmée J Grobbee, Patrick M Bossuyt, Amanda C R K Bos, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Manon C W Spaander, Evelien Dekker
BACKGROUND & AIMS: European guidelines recommend screening for colorectal cancer (CRC) using the fecal immunochemical test (FIT), with follow-up colonoscopies for individuals with positive test results. However, more than half of participants with positive results from the FIT are not found to have advanced neoplasia in the colonoscopy examination. Fecal occult blood might also come from the upper gastrointestinal (GI) tract, so perhaps we should consider esophagogastroduodenoscopy (EGD), to detect upper GI cancers...
February 7, 2018: Clinical Gastroenterology and Hepatology
Roisin Bevan, Matthew D Rutter
Colorectal cancer (CRC) is the third most common cancer worldwide. It is amenable to screening as it occurs in premalignant, latent, early, and curable stages. PubMed, Cochrane Database of Systematic Reviews, and national and international CRC screening guidelines were searched for CRC screening methods, populations, and timing. CRC screening can use direct or indirect tests, delivered opportunistically or via organized programs. Most CRCs are diagnosed after 60 years of age; most screening programs apply to individuals 50-75 years of age...
January 2018: Clinical Endoscopy
Takuma Kishimoto, Kenji Nanishi, Hirotaka Furuke, Chikage Kato, Kazuya Takabatake, Tatsuya Kumano, Kenichiro Imura, Katsumi Shimomura, Takeshi Kubota, Jun Ikeda, Fumihiro Taniguchi, Kenichiro Takashina, Yasuhiro Shioaki, Eito Ikeda
A 67-year-old male was referred to our hospital for further investigation of fecal occult blood. We diagnosed him with rectal cancer with osseous metastasis. Chemo-and radiation therapy were administered following resection of the rectal cancer. There were no other lesions except for the osseous metastasis remaining after these interventions. The osseous lesion was then resected. There have no signs of recurrence for 1 year and 9 months since the last operation. We report a case of successful resection of osseous metastasis from rectal cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hajime Ushigome, Yoshiya Fujimoto, Shinsuke Suzuki, Hironori Minami, Shun Miyanari, Satoshi Murahashi, Hironori Fukuoka, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Satoshi Nagayama, Yosuke Fukunaga, Masashi Ueno, Akiko Chino, Masahiro Igarashi
A screening fecal occult blood test was positive in a 76-year-old female. Colonoscopy showed laterally spreading tumor (LST)over 15 cm at lower rectum. endoscopic submucosal dissection(ESD)was performed. Pathological findings showed LST-G, 150×100 mm, adenocarcinoma(tub1-tub2), tubular adenoma, moderate-severe atypia, Tis(M), ly(-), v(-), HMX, VMX. Two years later CT detected one swollen lymph node at mesorectum and PET-CT showed FDG up take at the lymph node. We diagnosed lymph node metastasis, performed laparoscopic very low anterior resection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masahiro Maruyama, Takatoshi Nakamura, Takafumi Soeno, Masashi Shimazu, Atsuko Tsutsui, Hiroshi Tajima, Hirohisa Miura, Takahiro Yamanashi, Takeo Satoh, Yusuke Kumamoto, Masahiko Watanabe
The patient was a 52-year-old man who had a positive fecal occult-blood test on a medical check-upi n April 2015 and was referred to our hospital in June. Detailed preoperative examinations resulted in a diagnosis of cancer of the lower rectum, multiple liver metastases, and clinical Stage IV . A biopsy showed moderately differentiated tubular adenocarcinoma. All-RAS was wild type, and the patient was asymptomatic. Unresectable advanced rectal cancer was diagnosed, and the patient was scheduled to receive systemic chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yu Wang, Pei-Min Chen, Rong-Bin Liu
This review article summarizes the research advances of the plasma-based SEPT9 gene methylation assay for the clinical detection of colorectal cancer and its limitations. Colorectal cancer is a common malignancy with a poor prognosis and a high mortality, for which early detection and diagnosis are particularly crucial for the high-risk groups. Increasing evidence supported that SEPT9 gene methylation is associated with the pathogenesis of colorectal cancer and that detecting the level of methylation of SEPT9 in the peripheral blood can be used for screening of colorectal cancer in susceptible populations...
January 15, 2018: World Journal of Gastrointestinal Oncology
Y Li, H Z Liu, Y R Liang, G Z Lin, K Li, H Dong, H Xu, M Wang
Objective: To analyze the effect of colorectal cancer screening in the general population in Guangzhou, and provide evidence for the for development of colorectal cancer screening policy and strategy. Methods: The data of colorectal cancer screening in Guangzhou during 2015- 2016 were collected. The participation, the positive rate of fecal occult blood test, the detection rate of colonoscopy and screening effect of colonoscopy were evaluated. Results: A total of 220 834 residents aged 50-74 years received the screening, and the positive rate of the screening was 16...
January 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Ryota Mori, Kohei Murata, Yoshinori Kagawa, Yohei Nose, Kenji Kawai, Takuya Sakamoto, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Toru Masuzawa, Atsushi Takeno, Yutaka Takeda
A 63-year-old man with multiple endocrine neoplasia type 2(MEN2)was admitted to the hospital because of positive fecal occult blood tests. Colonoscopy revealed a 50mm type 2 tumor at the rectum, which was diagnosed as an adenocarcinoma based on histology. Since there was no apparent distant metastasis, laparoscopy-assisted low anterior resection with regional lymph node dissection was performed. The final diagnosis was pT3, pN0, pM0, pStage II . Almost all patients with MEN2 have RET mutations, and they are resistant to EGFR inhibitors...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Akinobu Furutani, Akio Shiomi, Yusuke Kinugasa, Tomohiro Yamaguchi, Hiroyasu Kagawa, Yushi Yamakawa, Shoichi Manabe, Yusuke Yamaoka, Yusuke Ogi, Yoshinobu Nagasawa, Hitoshi Hino, Shunichiro Kato, Takuya Suzuki, Kakeru Torii, Kohei Koido
Polysplenia syndrome is a rare congenital disease characterized by variable thoracic and abdominal anomalies. A man in his 70s was diagnosed with rectal cancer by close exploration for fecal occult blood. A barium enema revealed a type 1 rectal tumor andwith non-rotation of intestine. CT revealed multiple abnormalities: a polyspleen, preduodenal portal vein, congenital absence of the pancreatic tail, bilateral superior vena cava, andbilateral bilobedlung. Basedon these findings, the patient was diagnosedas having rectal cancer with polysplenia syndrome andtreatedwith robotic assistedlaparoscopic low anterior resection...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Yuta Muto, Kentaro Chochi, Daisaku Morita, Atsuo Oka, Toshiki Rikiyama
Colorectal cancer is a common malignancy and a major health issue in geriatrics. Systemic chemotherapy should be considered for elderly patients. We report an 85-year-old man with metastatic cecal cancer who has achieved long-term survival following single-agent chemotherapy with S-1. His fecal occult blood test results were positive; he then underwent colonoscopy and was diagnosed with cecal cancer. Chest CT revealed multiple metastases in both lungs. Since radical excision was infeasible, we performed right hemicolectomy to prevent bowel obstruction...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Florence Bénard, Alan N Barkun, Myriam Martel, Daniel von Renteln
AIM: To summarize and compare worldwide colorectal cancer (CRC) screening recommendations in order to identify similarities and disparities. METHODS: A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website, Google and Google Scholar was performed...
January 7, 2018: World Journal of Gastroenterology: WJG
Simone Lee, Andrea Miller
The objective of this scoping review is to examine and map the evidence on the range of factors influencing a person's decision to screen or not screen for colorectal cancer using a fecal occult blood test (FOBT) in Australia, with the view to identifying gaps in the research and informing appropriate questions for future systematic reviews.The question of this review is: what evidence is available around the barriers and facilitators that influence an individual's decision to screen or not screen for colorectal cancer using a fecal occult blood test in Australia?...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
Melinda M Davis, Michele Freeman, Jackilen Shannon, Gloria D Coronado, Kurt C Stange, Jeanne-Marie Guise, Stephanie B Wheeler, David I Buckley
BACKGROUND: Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors influenced the uptake of interventions to increase Fecal Immunochemical Tests (FIT) and Fecal Occult Blood Testing (FOBT) for CRC in rural and low-income populations in the United States. METHODS: We searched Medline and the Cochrane Library from January 1998 through July 2016, and Scopus and clinicaltrials...
January 6, 2018: BMC Cancer
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