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https://www.readbyqxmd.com/read/28922370/ileocolic-resection-is-associated-with-increased-susceptibility-to-injury-in-a-murine-model-of-colitis
#1
Troy Perry, Michael Laffin, Richard N Fedorak, Aducio Thiesen, Bryan Dicken, Karen L Madsen
Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immunologic changes that developed around the surgical anastomosis and how these changes impacted gut responses to minor acute injury. ICR was performed in adult 129S1/SvlmJ mice and results compared with mice receiving sham or no surgery. Dextran sodium sulfate was given either on post-operative day 9 or day 24 to evaluate immune responses in the intestine both immediately following surgery and after a period of healing...
2017: PloS One
https://www.readbyqxmd.com/read/28894391/comment-on-fecal-occult-blood-versus-dna-testing-indirect-comparison-in-a-colorectal-cancer-screening-population
#2
COMMENT
David A Ahlquist
No abstract text is available yet for this article.
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28887191/factors-influencing-participation-in-colorectal-cancer-screening-programs-in-spain
#3
Mercedes Vanaclocha-Espi, Josefa Ibáñez, Ana Molina-Barceló, Elena Pérez, Andreu Nolasco, Rebeca Font, Francisco Pérez-Riquelme, Mariola de la Vega, Eunate Arana-Arri, MªElena Oceja, Josep Alfons Espinàs, Isabel Portillo, Dolores Salas
To analyze the sociodemographic and organizational factors influencing participation in population-based colorectal cancer screening programs (CRCSP) in Spain, a retrospective study was conducted in a cohort of people invited to participate in the first 3 screening rounds of 6 CRCSP from 2000 to 2012. Mixed logistic regression models were used to analyze the relationship between sociodemographic and organizational factors, such as the type of fecal occult blood test (FOBT) used and the FOBT delivery type. The analysis was performed separately in groups (Initial screening-first invitation, Subsequent invitation for previous never-responders, Subsequent invitation-regular, Subsequent invitation-irregular intervals)...
September 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28883295/a-case-of-granulomatous-inflammation-of-the-sigmoid-colon-caused-by-a-fish-bone-that-resembled-cancer
#4
Hiroshi Kitagawa, Shiro Matsukura, Koichi Miyahara, Izumi Akagawa, Seiji Yunotani
This case involved a 76-year-old man. Total colonoscopy was performed as a second examination for colorectal cancer because of positive fecal occult blood results, revealing a neoplasm with ulceration in the sigmoid colon. We suspected type-3 colorectal cancer and performed a biopsy, but the biopsy diagnosis showed only an ulcer with active inflammation. Colonoscopic re-examination in a highly advanced medical institution revealed granulomatous inflammation of the sigmoid colon caused by a fish bone, and the fish bone was removed endoscopically...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28875497/cancer-screening-of-older-adults-in-israel-according-to-life-expectancy-cross-sectional-study
#5
Ronen Bareket, Mara A Schonberg, Doron Comaneshter, Yochai Schonmann, Michal Shani, Arnon Cohen, Shlomo Vinker
OBJECTIVES: To examine over-screening of older Israelis for colon and breast cancer. DESIGN: Cross sectional. SETTING: Clalit Health Services (CHS), Israel's largest health maintenance organization (HMO), provides care for more than half of the country's population and operates a national age-based programs for cancer screening. PARTICIPANTS: All community-dwelling members aged 65 to 79 in 2014 (N = 370,876). MEASUREMENTS: We used CHS data warehouse to evaluate cancer screening during 2014...
September 5, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28870234/collection-of-non-meconium-stool-on-fecal-occult-blood-cards-is-an-effective-method-for-fecal-microbiota-studies-in-infants
#6
Wendy S W Wong, Nicole Clemency, Elisabeth Klein, Marina Provenzano, Ramaswamy Iyer, John E Niederhuber, Suchitra K Hourigan
BACKGROUND: Effective methods are needed to collect fecal samples from children for large-scale microbiota studies. Stool collected on fecal occult blood test (FOBT) cards that can be mailed provides an effective solution; however, the quality of sequencing resulting from this method is unknown. The aim of this study is to compare microbiota metrics of 16S ribosomal RNA (rRNA) gene sequencing from stool and meconium collected on FOBT cards with stool collected in an Eppendorf tube (ET) under different conditions...
September 5, 2017: Microbiome
https://www.readbyqxmd.com/read/28867474/fecal-immunological-blood-test-is-more-appealing-than-the-guaiac-based-test-for-colorectal-cancer-screening
#7
Fanny Le Pimpec, Grégoire Moutel, Christine Piette, Astrid Lièvre, Jean-François Bretagne
BACKGROUND: The reasons for participation in fecal immunological testing (FIT) of subjects who were previously non-respondents to guaiac fecal occult blood testing (g-FOBT) have not been assessed. POPULATION AND METHODS: We aimed to determine the reasons for current compliance with FIT among non-responders to g-FOBT, termed "converts", in a French district. A questionnaire was returned by 170 converts aged from 55 to 75 years (response rate 75.2% after exclusions)...
August 10, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28863872/decision-making-in-fecal-occult-blood-test-compliance-a-quali-quantitative-study-investigating-motivational-processes
#8
G Broc, B Denis, J-B Fassier, I Gendre, P Perrin, B Quintard
The qualitative-quantitative study investigates the co-existence of barriers and levers to FOBT screening in 5894 individuals reluctant to be screened, identifying operational motivational patterns that may increase screening compliance. Co-occurrence analysis was performed according to three motivational conditions (barriers, levers, or both).Cluster analysis then identified motivational predictors of effective screening. One quarter of the individuals who had refused screening nevertheless expressed at least one motivation towards FOBT...
August 31, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28856900/annals-express-the-development-of-an-artificial-stool-usable-for-the-surveillance-of-fecal-hemoglobin-testing
#9
Akira Miike, Zensuke Ogawa, Ikunosuke Sakurabayashi
Backgrounds; Fecal occult blood testing (FOBT) is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods; We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneously contains not only human hemoglobin A0(HbA0), but also glycerol as an internal standard material. After the collection of the artificial stool into a buffer, the Hb concentration in dispersed solution was measured using a method based on the peroxidase like activity of Hb...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28842164/colorectal-cancer-screening-in-rural-and-poor-resourced-communities
#10
Michael A Preston, Katherine Glover-Collins, Levi Ross, Austin Porter, Zoran Bursac, Delores Woods, Jacqueline Burton, Karen Crowell, Jonathan Laryea, Ronda S Henry-Tillman
To test the efficacy of a community-based intervention, Empowering Communities for Life (EC4L), designed to increase colorectal cancer (CRC) screening through fecal occult blood test (FOBT) in rural underserved communities in a randomized controlled trial. Participants were randomized into 3 groups (2 interventions and 1 control). Interventions were delivered by community lay health workers or by academic health professionals. The main outcome of interest was return rate of FOBT screening kit within 60 days...
August 12, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28835241/rectal-carcinoma-and-multiple-gastrointestinal-stromal-tumors-gist-of-the-small-intestine-in-a-patient-with-neurofibromatosis-type-1-a-case-report
#11
Yuhei Hakozaki, Shinichi Sameshima, Teppei Tatsuoka, Takashi Okuyama, Yukinori Yamagata, Tamaki Noie, Masatoshi Oya, Akiko Fujii, Yoshihiko Ueda, Chieko Shimura, Kazumoto Katagiri
BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomally dominant inherited disorder characterized by multiple pigmented skin spots (café-au-lait spots) and neurofibroma. NF1 is associated with a wide variety of benign or malignant tumors. We report a NF1 patient who received surgical treatment for rectal carcinoma and multifocal small intestinal gastrointestinal stromal tumors (GISTs). CASE PRESENTATION: A 70-year-old female patient with NF1 was referred to our hospital after a positive fecal occult blood test...
August 23, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28813112/what-do-cochrane-systematic-reviews-say-about-the-clinical-effectiveness-of-screening-and-diagnostic-tests-for-cancer
#12
André Tito Pereira Bueno, Vladimir Lisboa Capelasso, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca, Tiago Biachi de Castria, Daniela Vianna Pachito, Rachel Riera
CONTEXT AND OBJECTIVE: The purpose of screening tests for cancer is to detect it at an early stage in order to increase the chances of treatment. However, their unrestrained use may lead to unnecessary examinations, overdiagnosis and higher costs. It is thus necessary to evaluate their clinical effects in terms of benefits and harm. DESIGN AND SETTING: Review of Cochrane systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28812930/increasing-colorectal-cancer-screening-at-an-urban-fqhc-using-ifobt-and-patient-navigation
#13
Richard L Martin, Madelaine Tully, Allison Kos, David Frazer, Amy Williamson, Amy Conlon, James J Enser, Noelle K LoConte
INTRODUCTION: Colorectal cancer is the second leading cause of cancer death in the United States. Black Americans suffer even higher incidence and death rates than the general population. Genetics and patient perceptions explain some of this difference, however, modifiable health care system factors such as lack of access to colon cancer screening also contribute. Partnering an academic health center with local community groups, we piloted a colorectal cancer screening program at a Federally Qualified Health Center (FQHC) serving predominately low socioeconomic status Black Americans...
September 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28804005/performance-assessment-of-the-saps-ii-and-sofa-scoring-systems-in-hanta-virus-hemorrhagic-fever-with-renal-syndrome
#14
Zhenjun Yu, Ni Zhou, Ali Li, Jie Chen, Huazhong Chen, Zebao He, Fei Yan, Haihong Zhao, Jiansheng Zhu
BACKGROUND: Hemorrhagic Fever with Renal Syndrome (HFRS), caused by the hantavirus, is a natural infectious disease characterized by fever, hemorrhage and renal damage. China is the most severely endemic area for HFRS in the world. In recent years, critical scoring systems based on quantitative classification have become an important clinical tool for predicting and evaluating the prognosis of critical illness, and provide guidelines for clinical practice. METHODS: The sample comprised 384 patients with HFRS treated in the Taizhou Hospital from January 2006 to February 2017...
August 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28799068/colorectal-cancer-screening-in-asia
#15
REVIEW
Han-Mo Chiu, Wen-Feng Hsu, Li-Chun Chang, Ming-Hsiang Wu
PURPOSE OF REVIEW: Colorectal cancer (CRC) is increasing in Asia, especially in regions with higher levels of economic development. Several Asian countries have launched population CRC screening programs to combat this devastating disease because previous studies have demonstrated that either fecal occult blood test or lower gastrointestinal endoscopy can effectively reduce CRC mortality. RECENT FINDINGS: Screening includes engaging the population, testing, administering a confirmation examination, and treating screening-detected neoplasms; thus, monitoring the whole process using measurable indicators over time is of utmost importance...
August 10, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28761377/fecal-occult-blood-versus-dna-testing-indirect-comparison-in-a-colorectal-cancer-screening-population
#16
Hermann Brenner, Hongda Chen
BACKGROUND: A multitarget stool DNA test (MSDT) that showed higher sensitivity but lower specificity than a fecal immunochemical test (FIT) for hemoglobin in one recent study from the US and Canada, is increasingly used for colorectal cancer (CRC) screening, despite its ~20-fold higher costs compared to FITs. We aimed to assess diagnostic performance of a quantitative FIT in an independent study among participants of screening colonoscopy and to compare it with the previously reported performance of MSDT...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28754720/tert-promoter-hypermethylation-in-gastrointestinal-cancer-a-potential-stool-biomarker
#17
Li Liu, Cheng Liu, Omid Fotouhi, Yidong Fan, Kun Wang, Chuanyou Xia, Benkang Shi, Guangyong Zhang, Kexin Wang, Feng Kong, Catharina Larsson, Sanyuan Hu, Dawei Xu
BACKGROUND: There is a high demand for noninvasive screening tools for gastrointestinal cancer (GIC) detection, and GIC-specific markers are required for such purposes. It is established that induction of the telomerase reverse transcriptase gene (TERT) coupled with telomerase activation is essential for cancer development/progression and aberrant TERT promoter methylation of specific 5'-C-phosphate-G-3' (CpGs) has been linked to TERT induction in oncogenesis. Here we analyzed TERT promoter methylation in fecal samples from GIC patients and healthy adults and determined its value as a stool biomarker for GIC detection...
July 28, 2017: Oncologist
https://www.readbyqxmd.com/read/28753700/a-new-composite-measure-of-colonoscopy-the-performance-indicator-of-colonic-intubation-pici
#18
Roland M Valori, Sarah Damery, Daniel R Gavin, John T Anderson, Mark T Donnelly, J Graham Williams, Edwin T Swarbrick
Background and study aim Cecal intubation rate (CIR) is an established performance indicator of colonoscopy. In some patients, cecal intubation with acceptable tolerance is only achieved with additional sedation. This study proposes a composite Performance Indicator of Colonic Intubation (PICI), which combines CIR, comfort, and sedation. Methods Data from 20 085 colonoscopies reported in the 2011 UK national audit were analyzed. PICI was defined as the percentage of procedures achieving cecal intubation with median dose (2 mg) of midazolam or less, and nurse-assessed comfort score of 1 - 3/5...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28733869/bmi-is-a-risk-factor-for-colorectal-cancer-mortality
#19
Aasma Shaukat, Allison Dostal, Jeremiah Menk, Timothy R Church
BACKGROUND: The relationship between dietary and lifestyle risk factors and long-term mortality from colorectal cancer is poorly understood. Several factors, such as obesity, intakes of red meat, and use of aspirin, have been reported to be associated with risk of colorectal cancer mortality, though these findings have not been replicated in all studies to date. METHODS: In the Minnesota Colon Cancer Control Study, 46,551 participants 50-80 years old were randomly assigned to usual care (control) or annual or biennial screening by fecal occult blood testing...
July 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28730505/stool-based-testing-for-colorectal-cancer-an-overview-of-available-evidence
#20
REVIEW
Kevin M Rank, Aasma Shaukat
PURPOSE OF REVIEW: The goal of this review is to summarize stool-based testing for colorectal cancer (CRC). The key questions answered in this review were the advantages and limitations of each available stool-based test for CRC and to examine their comparative efficacy. RECENT FINDINGS: Guaiac-based fecal occult blood testing (gFOBT) is no longer a relevant test for CRC screening. fecal immunochemical testing (FIT) tests, especially quantitative assays, are clearly a reliable stool-based test...
August 2017: Current Gastroenterology Reports
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