Mayuko Kanayama, Yidong Chen, Daniel Rabizadeh, Lauren Vera, Changxue Lu, Sarah M Nielsen, Emily M Russell, Edward D Esplin, Hao Wang, William B Isaacs, Emmanuel S Antonarakis, Jun Luo
BACKGROUND: Recent reports have uncovered a HOXB13 variant (X285K) predisposing to prostate cancer in men of West African ancestry. The clinical relevance and protein function associated with this inherited variant are unknown. OBJECTIVE: To determine the clinical relevance of HOXB13 (X285K) in comparison with HOXB13 (G84E) and BRCA2 pathogenic/likely pathogenic (P/LP) variants, and to elucidate the oncogenic mechanisms of the X285K protein. DESIGN, SETTING, AND PARTICIPANTS: Real-world data were collected from 21,393 men with prostate cancer undergoing genetic testing from 2019 to 2022, and in vitro cell-line models were established for the evaluation of oncogenic functions associated with the X285K protein...
October 6, 2023: European Urology Oncology