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https://www.readbyqxmd.com/read/27882139/the-association-between-the-levels-of-crp-il-10-pla2-fbg-and-prognosis-in-traumatic-fracture-of-lower-limb
#1
Jing Jiao, Jun-Wen Wang, Fei Xiao, Yu-Cheng Huang
The aim of the present study was to examine changes of sera levels of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) in patients with traumatic fracture of lower limb, and to evaluate their association with prognosis. The changes in sera levels of CRP, IL-10, PLA2 and Fbg were observed at the time of injury, 24 h, and 5 and 7 days after surgery in 90 patients with traumatic fracture of lower limb. In addition, 50 cases, who presented for health examination, were included as the normal controls...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27874910/short-versus-long-cephalomedullary-nails-for-pertrochanteric-hip-fracture
#2
Nicholas B Frisch, Nickolas J Nahm, Jad G Khalil, Clifford M Les, Stuart T Guthrie, Michael A Charters
This study compared patients who underwent treatment with short or long cephalomedullary nails with integrated cephalocervical screws and linear compression. Patients with AO/OTA 31-A2 or A3 pertrochanteric fractures treated with either short (n=72) or long (n=97) InterTAN (Smith & Nephew, Memphis, Tennessee) cephalomedullary nails were reviewed. Information on perioperative measures (estimated blood loss, surgical time, and fluoroscopy time) and postoperative orthopedic complications (infection, implant failure, screw cutout, and periprosthetic femur fracture) was included...
November 22, 2016: Orthopedics
https://www.readbyqxmd.com/read/27863211/comparison-of-two-methods-for-measuring-25-oh-vitamin-d-in-the-follow-up-of-patients-after-bilio-pancreatic-diversion-bariatric-surgery
#3
Ahlem Chouiali, Pierre-Luc Mallet, Guy Fink, Simon Biron, Marie-France Langlois
OBJECTIVE: Our objective was to compare the ECLIA from Roche versus the LC-MS/MS method for quantitation of serum 25-hydroxy-vitamin D in patients who have undergone bariatric surgery. DESIGN AND METHODS: Cross-sectional and correlational studies were performed on three different groups for the 25-OH-D levels quantitated by both methods. The control group of apparently healthy subjects was randomly selected in a clinical chemistry laboratory. Test groups were patients who had undergone bilio-pancreatic diversion (BPD) and were supplemented either with vitamin D2 or with vitamin D3...
November 15, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27858574/quantitative-anatomical-analysis-and-clinical-experience-with-mini-pterional-and-mini-orbitozygomatic-approaches-for-intracranial-aneurysm-surgery
#4
Kaan Yagmurlu, Sam Safavi-Abbasi, Evgenii Belykh, M Yashar S Kalani, Peter Nakaji, Albert L Rhoton, Robert F Spetzler, Mark C Preul
OBJECTIVE The aim of this investigation was to modify the mini-pterional and mini-orbitozygomatic (mini-OZ) approaches in order to reduce the amount of tissue traumatization caused and to compare the use of the 2 approaches in the removal of circle of Willis aneurysms based on the authors' clinical experience and quantitative analysis. METHODS Three formalin-fixed adult cadaveric heads injected with colored silicone were examined. Surgical freedom and angle of attack of the mini-pterional and mini-OZ approaches were measured at 9 anatomical points, and the measurements were compared...
November 18, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27807112/reverse-total-shoulder-arthroplasty-without-bone-grafting-for-severe-glenoid-bone-loss-in-patients-with-osteoarthritis-and-intact-rotator-cuff
#5
Edward G McFarland, Gazi Huri, Yoon Suk Hyun, Steve A Petersen, Uma Srikumaran
BACKGROUND: Treating shoulders with osteoarthritis, an intact rotator cuff, and substantial glenoid bone loss is challenging. One option is reaming the glenoid flat and inserting a reverse prosthesis. This study reports the subjective, objective, and radiographic results of reverse total shoulder arthroplasty (RTSA) in this population. METHODS: We retrospectively reviewed 42 consecutive patients (23 women; mean age, 71 years [range, 53 to 89 years]) with primary glenohumeral osteoarthritis, intact rotator cuffs, and Walch type-A2 (n = 19), B2 (n = 5), or C glenoids (n = 18) who had undergone a total of 42 RTSAs with glenoid reaming without bone-grafting between 2008 and 2013 (mean follow-up, 36 months [range, 24 to 66 months])...
November 2, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27805237/the-role-of-genetics-in-coronary-artery-bypass-surgery-patients-under-30-years-of-age
#6
Sabit Sarikaya, Ebuzer Aydin, Yucel Ozen, Tanil Ozer, Kaan Kirali, Murat Bulent Rabus
AIM: We undertook genetic assessment of coronary artery disease (CAD) in 20 patients aged 30 years or less undergoing coronary artery bypass grafting (CABG) surgery, to investigate the prognostic value of pre-defined genes. METHODS: Twenty patients, who underwent CABG surgery between December 2001 and May 2013, were retrospectively analysed to find out the role their genetic make-up played in their disease. We used three genetic diagnostic tests, the plasminogen activator inhibitor (PAI) -1 gene, the A1/A2 polymorphism of glycoprotein IIIa (GpIIIa) gene, and common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene...
October 21, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27802890/the-use-of-interfragmentary-positional-screw-in-minimally-invasive-plate-osteosynthesis-for-simple-distal-femur-fractures-in-elderly-patients-a-retrospective-single-centre-pilot-study
#7
Jun Young Chung, Jae Ho Cho, Heon Ju Kweon, Hyung Keun Song
INTRODUCTION: Minimally invasive plate osteosynthesis (MIPO) using locking plates has been used in distal femur fractures, but various problems, such as nonunion, malalignment, and implant failure, have been reported. Simple fractures sometimes have poorer outcomes than complex fractures. We studied elderly patients with simple fracture patterns who underwent open reduction followed by placement of a single positional screw to hold the reduced interfragmentary gap, and compared these cases with patients who underwent surgery using conventional MIPO techniques...
December 2016: Injury
https://www.readbyqxmd.com/read/27792220/anterior-cruciate-ligament-injury-profile-in-italian-serie-a1-a2-women-s-volleyball-league
#8
Francesca Devetag, Massimiliano Mazzilli, Roberto Benis, Antonio La Torre, Matteo Bonato
BACKGROUND: The aim of this study was to assess how anterior cruciate ligament (ACL) ruptures with subsequently surgery reconstruction were sustaining during the professional career of women's' volleyball players of A1-A2 Italian volleyball league. METHODS: Using an observational study with a retrospective case-series design for ACL ruptures, 125 teams with 1488 players were monitored. Subjects had to report level, role, injury modality, lower limb injured, laterality, period of the season and age...
October 28, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27784647/annexin-a2-and-alpha-actinin-4-expression-correlates-with-metastatic-potential-of-primary-endometrial-cancer
#9
Parul Mittal, Manuela Klingler-Hoffmann, Georgia Arentz, Lyron Winderbaum, Gurjeet Kaur, Lyndal Anderson, James Scurry, Yee Leung, Colin Jr Stewart, Jonathan Carter, Peter Hoffmann, Martin K Oehler
The prediction of lymph node metastasis using clinic-pathological data and molecular information from endometrial cancers lacks accuracy and is therefore currently not routinely used in patient management. Consequently, although only a small percentage of patients with endometrial cancers suffer from metastasis, the majority undergo radical surgery including removal of pelvic lymph nodes. Upon analysis of publically available data and published research, we compiled a list of 60 proteins having the potential to display differential abundance between primary endometrial cancers with versus those without lymph node metastasis...
October 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27755187/macular-corneal-dystrophy-and-posterior-corneal-abnormalities
#10
Yair Rubinstein, Chen Weiner, Adi Einan-Lifshitz, Noa Chetrit, Nadav Shoshany, David Zadok, Isaac Avni, Eran Pras
PURPOSE: This study reports the presentation of 2 families with macular corneal dystrophy (MCD). The aim of this study was to show whether ultrasound biomicroscopy (UBM) can, based on posterior changes of the cornea in MCD, assist in the choice of surgery, either anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK), compared with optical coherence tomography (OCT) and Scheimpflug. METHODS: Six patients with MCD were examined for their best-corrected visual acuity, slit-lamp, OCT, UBM, and Scheimpflug findings...
October 14, 2016: Cornea
https://www.readbyqxmd.com/read/27689401/expression-of-the-tp%C3%AE-and-tp%C3%AE-isoforms-of-the-thromboxane-prostanoid-receptor-tp-in-prostate-cancer-clinical-significance-and-diagnostic-potential
#11
Eamon P Mulvaney, Christine Shilling, Sarah B Eivers, Antoinette S Perry, Anders Bjartell, Elaine W Kay, R William Watson, B Therese Kinsella
The prostanoid thromboxane (TX)A2 plays a central role in haemostasis and is increasingly implicated in cancer progression. TXA2 signals through two T Prostanoid receptor (TP) isoforms termed TPα and TPβ, with both encoded by the TBXA2R gene. Despite exhibiting several functional and regulatory differences, the role of the individual TP isoforms in neoplastic diseases is largely unknown.This study evaluated expression of the TPα and TPβ isoforms in tumour microarrays of the benign prostate and different pathological (Gleason) grades of prostate cancer (PCa)...
September 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27608913/dexmedetomidine-regulate-the-malignancy-of-breast-cancer-cells-by-activating-%C3%AE-2-adrenoceptor-erk-signaling-pathway
#12
M Xia, N-N Ji, M-L Duan, J-H Tong, J-G Xu, Y-M Zhang, S-H Wang
OBJECTIVE: Breast cancer is one of the most aggressive and pervasive cancers identified in females. Dexmedetomidine (Dex) is an efficient anesthetic used in surgery. Our study aimed to explore the role of Dex in the malignancy of breast cancer cells in vitro and in vivo. Further, we investigate the molecular mechanism involved in the function of Dex on breast cancer cells. MATERIALS AND METHODS: The methyl thiazolyl tetrazolium (MTT) assay was applied to detect cell proliferation...
August 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27584674/temporary-percutaneous-instrumentation-and-selective-anterior-fusion-for-thoracolumbar-fractures
#13
Yann Philippe Charles, Axel Walter, Sébastien Schuller, Jean-Paul Steib
STUDY DESIGN: Prospective clinical trial in thoracolumbar trauma with 5-year follow-up. OBJECTIVE: To analyze clinical and radiographic outcomes of minimal invasive surgery, and the rational of circumferential fracture treatment with regard to age, degenerative changes, bone mineral density and global sagittal balance. SUMMARY OF BACKGROUND DATA: Non-neurologic fractures with anterior column defect can be treated by posterior percutaneous instrumentation and selective anterior fusion...
August 31, 2016: Spine
https://www.readbyqxmd.com/read/27542766/a-threshold-of-systemic-mage-a-gene-expression-predicting-survival-in-resected-non-small-cell-lung-cancer
#14
Ingo Mecklenburg, Wulf Sienel, Severin Schmid, Bernward Passlick, Peter Kufer
PURPOSE: Quantitative measurement of minimal residual disease (MRD) predicting recurrence in individual cancer patients is available only in very few indications such as acute lymphoblastic leukemia but is still missing in most solid tumors including non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: MAGE-A expression levels in blood and bone marrow determined as calibrator normalized relative ratios by quantitative multimarker real-time RT-PCR for transcript amplification of MAGE-A1, -A2, -A3/6, -A4, -A10 and -A12 in 94 patients with completely resected NSCLC were correlated with survival in a clinical study...
August 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27538143/-primary-penoscrotal-extra-mammary-paget-s-disease-analysis-of-22-cases
#15
Z Q Bao, D Fang, C B Yue, L Cai, T Y Wang, X S Li, L Q Zhou
OBJECTIVE: To investigate the clinical characteristics, treatment and prognosis of primary penoscrotal extra-mammary Paget's disease (PSPD). METHODS: The clinical and pathological data of 22 cases of primary PSPD were retrospectively reviewed. Survival rate of the overall patients, the invasive patients, and the patients with positive surgical margin or negative surgical margin were analyzed with Kaplan-Meier survival curve method. RESULTS: Among all the patients with primary PSPD, the median age of onset was 64...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27523625/is-distal-locking-with-short-intramedullary-nails-necessary-in-stable-pertrochanteric-fractures-a-prospective-multicentre-randomised-study
#16
V Caiaffa, G Vicenti, C Mori, A Panella, V Conserva, G Corina, L Scialpi, A Abate, M Carrozzo, Leonardo Petrelli, G Picca, A Aloisi, G Rollo, M Filipponi, V Freda, A Pansini, A Puce, G Solarino, B Moretti
We investigated whether a proximal femoral nail can be implanted without a distal locking screw in AO/OTA 31-A1 and 31-A2 pertrochanteric stable femur fractures. A multicentre, randomised study was conducted in six level-two trauma centres in our area (Puglia, Italy). A total of 333 patients received their allocated intervention (162 in the locking group [LG] and 171 in the unlocking group [UG]) and 266 patients were included in the final analysis at 1year. Our data showed no statistically significant difference between the two groups at 1-year follow-up for ability to walk, SF-36 questionnaire results, residual pain (visual analogue scale [VAS] score) and level of overall satisfaction...
August 11, 2016: Injury
https://www.readbyqxmd.com/read/27508651/-op-3b-02-ageing-and-lack-of-estrogens-activates-cyclooxygenases-pathway-increasing-superoxide-anion-production-in-response-to-thromboxane-a2
#17
S Novella, X Vidal-Gómez, A Mompeón, D Pérez-Cremades, G Segarra, P Medina, C Hermenegildo
OBJECTIVE: The role of ageing in the development of vascular disease is currently associated with a rise in oxidative stress. Thromboxane A2 (TXA2) is an inflammatory and oxidant endogenous vasoconstrictor which action increases with ageing and lack of estrogens, both conditions found in menopause. Our aim was to determine superoxide anion (O2-) levels in response to TXA2 in aortic vascular tissue from senescent and ovariectomized mice and the role of cyclooxygenase as source of O2-. DESIGN AND METHOD: Senescence accelerated mice (SAM) were used in this study...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27507546/long-endomedullary-nail-in-proximal-third-humeral-shaft-fractures
#18
Marco Caforio, Pietro Maniscalco, Massimiliano Colombo, Giorgio Maria Calori
INTRODUCTION: Proximal humeral fractures with a spiral line of fracture extending from the humeral head to the diaphyseal region are increasing. Treatment for these fractures is comparable to that for shaft fractures. The purpose of this study was to evaluate the use of a new "Long" humeral nail for this type of lesion and identify the best distal locking. MATERIALS AND METHODS: Forty-three patients treated with a Long Diphos Nail(®) were selected for this study: main exclusion criteria were poor cognitive and responsive ability to physical therapy, four-part fracture requiring humeral head replacement, an isolated greater or lesser tubercle fracture and a head-splitting fracture...
August 6, 2016: Injury
https://www.readbyqxmd.com/read/27465872/-comparison-of-the-clinical-efficacy-of-different-treatments-based-on-radical-surgery-in-stage-%C3%A2-b2-and-%C3%A2-a2-cervical-cancer-a-prospective-randomized-control-study
#19
X Li, W M Kong, C Han, Z Yan, H Zhao, W Y Zhang, J D Wang
OBJECTIVE: To compare the clinical efficacy of different treatments based on radical surgery in stage Ⅰ b2 and Ⅱ a2 cervical cancer through prospective randomized controlled study. METHODS: A total of 133 patients with stage Ⅰ b2 and Ⅱ a2 cervical cancer treated at Beijing Obstetrics and Gynecology Hospital of Capital Medical University during January 2009 to December 2012 were enrolled and randomly assigned to receive one of the following three treatments: preoperative intracavitary irradiation(PII)group, radical hysterectomy(RH)group, and neoadjuvant chemotherapy(NACT)group...
July 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27454538/a-novel-screw-head-design-of-pedicle-screw-for-reducing-the-correction-loss-in-the-patients-with-thoracolumbar-vertebral-fractures-a-biomechanical-study
#20
Bin Ye, Ming Yan, Huiyang Zhu, Wei Duan, Xueyu Hu, Zhengxu Ye, Zhuojing Luo
STUDY DESIGN: A biomechanical study. OBJECTIVE: To study the different biomechanical property among fixed-axis, monoplanar and polyaxial screws in the static and dynamic tests. SUMMARY OF BACKGROUND DATA: Correction loss is a common phenomenon in the patients with thoracolumbar vertebral fractures who underwent the posterior pedicle screw fixation. The incidence varies with the kinds of fixation instrumentation used. There is higher incidence in polyaxial pedicle screws group than in fixed-axis pedicle screws...
July 22, 2016: Spine
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