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https://www.readbyqxmd.com/read/28286182/crotalus-helleri-venom-preconditioning-reduces-postoperative-cerebral-edema-and-improves-neurological-outcomes-after-surgical-brain-injury
#1
Cherine H Kim, Devin W McBride, Prativa Sherchan, Carl E Person, Eric C K Gren, Wayne Kelln, Tim Lekic, William K Hayes, Jiping Tang, John H Zhang
INTRODUCTION: Postoperative cerebral edema is a devastating complication in neurosurgical patients. Loss of blood-brain barrier integrity has been shown to lead to the development of brain edema following neurosurgical procedures. The aim of this study was to evaluate preconditioning with Crotalus helleri venom (Cv-PC) as a potential preventive therapy for reducing postoperative brain edema in the rodent SBI model. C. helleri venom is known to contain phospholipase A2 (PLA2), an enzyme upstream to cyclooxygenase-2 (COX-2) in the inflammatory cascade, acts to increase the production of inflammatory mediators, such as prostaglandins...
March 9, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28274519/regional-heterogeneity-in-the-mitral-valve%C3%A2-apparatus-in-patients-with-ischemic%C3%A2-mitral-regurgitation
#2
Feroze Mahmood, Ziyad O Knio, Lu Yeh, Rabia Amir, Robina Matyal, Azad Mashari, Robert C Gorman, Joseph H Gorman, Kamal R Khabbaz
BACKGROUND: Apical displacement of the coaptation point of the mitral valve (MV) in response to ischemic mitral regurgitation (IMR) represents remodeling of the MV apparatus. Whereas it implies chronicity, it lacks specificity in discriminating normal from a significantly remodeled MV apparatus. Regional aspects of MV remodeling have shown superior value over global remodeling in predicting recurrence after MV repair for IMR. Quite possibly, presence of specific regional changes in MV geometry that are unique to chronic IMR patients could also be used to diagnose the presence and track progression of remodeling...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28273677/-first-results-with-a-resorbable-mgyrezr-compression-screw-in-unstable-scaphoid-fractures-show-extensive-bone-cysts
#3
Reinhard Meier, Martin Panzica
Osteosynthesis with headless compression screws is an established treatment option for unstable scaphoid fractures. Common implants are made of titanium alloy or steel and usually remain in place. Due to implant density and ferromagnetic properties, artefacts are common in postoperative imaging procedures, e.g. MRI. Now resorbable implants made of magnesium alloy (MgYREZr) have become available. They have biomechanical properties equivalent to human bone and may be used as an alternative to the nonresorbable screw systems...
March 8, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28241726/-bone-cement-dry-prosthetic-with-internal-fixation-treat-senile-osteoporotic-femoral-fractures
#4
Y Jiang, X X Rong, P Chen, Y J Xu, G X Zhu
Objective: To explore the treatment of senile osteoporotic femoral fractures after using internal fixation of bone cement dry prosthetic. Methods: Twelve patients aged from 74 to 94 years with mean age of (84.0±2.5) years with internal fixation of bone cement dry prosthetic surgery who were treated at Department of Orthopaedics in Nanjing Medical University Affiliated Wuxi Second Hospital between May 2013 and May 2015 were retrospectively analyzed. There were 8 male and 4 female, 10 cases of tumble and 2 cases of traffic injury...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28222145/cataract-surgery-causes-biomechanical-alterations-to-the-eye-detectable-by-corvis-st-tonometry
#5
Yoshitake Kato, Shunsuke Nakakura, Ryo Asaoka, Kanae Matsuya, Yuki Fujio, Yoshiaki Kiuchi
PURPOSE: Modern cataract surgery is generally considered to bring about modest and sustained intraocular pressure (IOP) reduction. However, the pathophysiological mechanism for this remains unclear. Moreover, a change in ocular biomechanical properties after surgery can affect the measurement of IOP. The aim of the study is to investigate ocular biomechanics, before and following cataract surgery, using Corvis ST tonometry (CST). PATIENTS AND METHODS: Fifty-nine eyes of 59 patients with cataract were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28212852/prevalence-of-proteinuria-and-other-abnormalities-in-urinalysis-performed-in-the-urology-clinic
#6
Adam Bezinque, Sabrina L Noyes, Samer Kirmiz, Jessica Parker, Sumi Dey, Richard J Kahnoski, Brian R Lane
OBJECTIVE: To compare the prevalence of proteinuria in the urology clinic with other outpatient settings. Chronic kidney disease is classified according to cause, glomerular filtration rate, and proteinuria. Proteinuria may be more prevalent in patients with known chronic kidney disease, renal disorders (benign or malignant), or after urologic surgery. METHODS: A cross-sectional study of 3 populations undergoing urinalysis (UA) testing was carried out: general outpatients (n = 20,334), urology outpatients (n = 5023), and kidney cancer patients (n = 1016)...
February 14, 2017: Urology
https://www.readbyqxmd.com/read/28203419/diagnosis-of-mitral-valve-cleft-using-real-time-3-dimensional-echocardiography
#7
Xinchun Yuan, Aiyun Zhou, Li Chen, Cheng Zhang, Yan Zhang, Pan Xu
BACKGROUND: Mitral valve cleft (MVC) is the most common cause of congenital mitral insufficiency, and MVC may occur alone or in association with other congenital heart lesions. Direct suture and valvuloplasty are the major and effective treatments for mitral regurgitation (MR) caused by MVC. Therefore, it is important to determine the location and magnitude of the pathological damage due to MVC when selecting a surgical procedure for treatment. This study explored the application value of transthoracic real-time 3-dimensional (3D) echocardiography (RT-3DE) in the diagnosis of MVC...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28196434/the-anatomy-of-wassel-type-iv-d-thumb-duplication
#8
B He, G Liu, G Nan
We describe Wassel type IV-D thumb duplication anatomy after surgery on 11 affected children (12 hands, seven boys (eight hands) and four girls). We studied the structure and course of the flexor pollicis longus tendon and its action at the joint. Four patients had secondary deformity associated with an absent A2 pulley and a tendon that clung to the radial side of a small thumb. In patients with primary deformity, the flexor tendon sheath became membranous in the A2 area and attached to neighbouring sites on the opposite side of the proximal phalanx...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28196433/outcomes-of-the-six-strand-m-tang-repair-for-zone-2-primary-flexor-tendon-repair-in-54-fingers
#9
X Zhou, X R Li, J Qing, X F Jia, J Chen
We repaired complete divisions of flexor tendons in zone 2 in 54 fingers using a six-strand core M-Tang repair method. Partial active digital motion started with early passive digital motion carried out first in the first 3-4 weeks after surgery and full range of active motion in later weeks. The patients were followed for 4-27 months. According to Strickland criteria or Tang criteria, 24 (83%) had excellent or good, four fair and one poor results in 28 fingers with follow-up of more than one year. In the other 25 fingers which were followed for less than 12 months, 19 (76%) had excellent and good, four fair and two poor results...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28191791/urethral-duplication-type-influences-on-the-complications-rate-and-number-of-surgical-procedures
#10
Roberto Iglesias Lopes, Amilcar Martins Giron, Marcos Figueiredo Mello, Cristovao Machado Barbosa Neto, Joana Dos Santos, Paulo Renato Marcelo Moscardi, Victor Srougi, Francisco Tibor Denes, Miguel Srougi
INTRODUCTION: Urethral duplication is rare. Characterized by the presence of two urethral channels. This anomaly presents a great variety of clinical findings that depend on the type of duplication that often is associated with other anomalies. MATERIAL AND METHODS: We report thirteen boys with urethral duplication managed in our institution between 1988-2015. Clinical findings, associated anomalies, treatment of urethral duplication and our results are described...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28178675/overexpression-of-karyopherin-a2-in-cholangiocarcinoma-correlates-with-poor-prognosis-and-gemcitabine-sensitivity-via-nuclear-translocation-of-dna-repair-proteins
#11
Mariko Tsukagoshi, Kenichiro Araki, Takehiko Yokobori, Bolag Altan, Hideki Suzuki, Norio Kubo, Akira Watanabe, Norihiro Ishii, Yasuo Hosouchi, Masahiko Nishiyama, Ken Shirabe, Hiroyuki Kuwano
Cholangiocarcinoma is a highly malignant tumor, and the development of new therapeutic strategies is critical. Karyopherin-α2 (KPNA2) functions as an adaptor that mediates nucleocytoplasmic transport. Specifically, KPNA2 transports one of the important DNA repair machineries, the MRE11-RAD50-NBS1 (MRN) complex, to the nucleus. In this study, we clarified the significance of KPNA2 in cholangiocarcinoma. KPNA2 expression evaluated by immunohistochemical analysis was common in malignant tissue but rare in adjacent noncancerous tissues...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28098212/different-volumetric-measurement-methods-for-pituitary-adenomas-and-their-crucial-clinical-significance
#12
Chi-Cheng Chuang, Shinn-Yn Lin, Ping-Ching Pai, Jiun-Lin Yan, Cheng-Hong Toh, Shih-Tseng Lee, Kuo-Chen Wei, Zhuo-Hao Liu, Chung-Ming Chen, Yu-Chi Wang, Cheng-Chi Lee
Confirming the status of residual tumors is crucial. In stationary or spontaneous regression cases, early treatments are inappropriate. The long-used geometric calculation formula is 1/2 (length × width × height). However, it yields only rough estimates and is particularly unreliable for irregularly shaped masses. In our study, we attempted to propose a more accurate method. Between 2004 and 2014, 94 patients with pituitary tumors were enrolled in this retrospective study. All patients underwent transsphenoidal surgery and received magnetic resonance imaging (MRI)...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094240/ectopic-bone-formation-by-gel-derived-bioactive-glass-poly-l-lactide-co-glycolide-composites-in-a-rabbit-muscle-model
#13
Joanna Filipowska, Katarzyna Cholewa-Kowalska, Jarosław Wieczorek, Danuta Semik, Zbigniew Dąbrowski, Maria Łączka, Anna M Osyczka
In this study we aimed to assess the in vivo osteoinductive properties of two composite scaffolds made of PLGA (poly-L-lactide-co-glycolide) and two types of gel-derived bioactive glasses, namely a high silica S2 bioactive glass (S2-PLGA composites) or high lime A2 bioactive glass (A2-PLGA composites). To achieve that, the potential of the composites to induce ectopic bone formation in a rabbit muscle has been examined along with the control PLGA scaffold. Cylinder-like scaffolds of 7  ×  3 mm (width  ×  height) were implanted into pouches created in the latissimus dorsi muscle of 18 New Zealand rabbits...
January 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28051217/changes-of-crohn-s-disease-phenotype-over-time
#14
Afef Ouaz, Monia Fekih, Asma Labidi, Nadia Ben Mustapha, Meriem Serghini, Lilia Zouiten, Jalel Boubaker, Azza Filali
Background - Crohn's disease is a clinically heterogeneous condition. Our aim was to identify the phenotype evolution of Crohn's disease over time according to the Montreal Classification and to precise predictive factors of the need for immunosuppressant treatment or surgery. Methods - We included Crohn's disease patients who were followed up for at least 5 years. We excluded patients who were lost to follow up before five. Patients were classified according to the Montreal classification for phenotype at diagnosis and five years later...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27939744/which-mechanism-is-effective-on-the-hyperamylasaemia-after-coronary-artery-bypass-surgery
#15
Halil Ibrahim Algin, Ali Ihsan Parlar, Ismail Yildiz, Zekiye Sultan Altun, Gul Huray Islekel, Ibrahim Uyar, Engin Tulukoglu, Ozalp Karabay
BACKGROUND AND AIM: Acute pancreatitis is one of the less frequently diagnosed lethal abdominal complications. The incidence of early postoperative period hyperamylasaemia was reported to be 30-70% of patients who underwent coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). The mechanism of pancreatic enzyme elevation after cardiac surgery is not clear. Our aim was to determine the relationship between ischaemia associated temporary renal dysfunction and elevation of pancreatic enzymes after CABG...
November 15, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27882139/the-association-between-the-levels-of-crp-il-10-pla2-fbg-and-prognosis-in-traumatic-fracture-of-lower-limb
#16
Jing Jiao, Jun-Wen Wang, Fei Xiao, Yu-Cheng Huang
The aim of the present study was to examine changes of sera levels of C-reactive protein (CRP), interleukin-10 (IL-10), phospholipase A2 (PLA2) and fibrinogen β polypeptide chain gene (Fbg) in patients with traumatic fracture of lower limb, and to evaluate their association with prognosis. The changes in sera levels of CRP, IL-10, PLA2 and Fbg were observed at the time of injury, 24 h, and 5 and 7 days after surgery in 90 patients with traumatic fracture of lower limb. In addition, 50 cases, who presented for health examination, were included as the normal controls...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27874910/short-versus-long-cephalomedullary-nails-for-pertrochanteric-hip-fracture
#17
Nicholas B Frisch, Nickolas J Nahm, Jad G Khalil, Clifford M Les, Stuart T Guthrie, Michael A Charters
This study compared patients who underwent treatment with short or long cephalomedullary nails with integrated cephalocervical screws and linear compression. Patients with AO/OTA 31-A2 or A3 pertrochanteric fractures treated with either short (n=72) or long (n=97) InterTAN (Smith & Nephew, Memphis, Tennessee) cephalomedullary nails were reviewed. Information on perioperative measures (estimated blood loss, surgical time, and fluoroscopy time) and postoperative orthopedic complications (infection, implant failure, screw cutout, and periprosthetic femur fracture) was included...
November 22, 2016: Orthopedics
https://www.readbyqxmd.com/read/27863211/comparison-of-two-methods-for-measuring-25-oh-vitamin-d-in-the-follow-up-of-patients-after-bilio-pancreatic-diversion-bariatric-surgery
#18
COMPARATIVE STUDY
Ahlem Chouiali, Pierre-Luc Mallet, Guy Fink, Simon Biron, Marie-France Langlois
OBJECTIVE: Our objective was to compare the ECLIA from Roche versus the LC-MS/MS method for quantitation of serum 25-hydroxy-vitamin D in patients who have undergone bariatric surgery. DESIGN AND METHODS: Cross-sectional and correlational studies were performed on three different groups for the 25-OH-D levels quantitated by both methods. The control group of apparently healthy subjects was randomly selected in a clinical chemistry laboratory. Test groups were patients who had undergone bilio-pancreatic diversion (BPD) and were supplemented either with vitamin D2 or with vitamin D3...
March 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27858574/quantitative-anatomical-analysis-and-clinical-experience-with-mini-pterional-and-mini-orbitozygomatic-approaches-for-intracranial-aneurysm-surgery
#19
Kaan Yagmurlu, Sam Safavi-Abbasi, Evgenii Belykh, M Yashar S Kalani, Peter Nakaji, Albert L Rhoton, Robert F Spetzler, Mark C Preul
OBJECTIVE The aim of this investigation was to modify the mini-pterional and mini-orbitozygomatic (mini-OZ) approaches in order to reduce the amount of tissue traumatization caused and to compare the use of the 2 approaches in the removal of circle of Willis aneurysms based on the authors' clinical experience and quantitative analysis. METHODS Three formalin-fixed adult cadaveric heads injected with colored silicone were examined. Surgical freedom and angle of attack of the mini-pterional and mini-OZ approaches were measured at 9 anatomical points, and the measurements were compared...
November 18, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27807112/reverse-total-shoulder-arthroplasty-without-bone-grafting-for-severe-glenoid-bone-loss-in-patients-with-osteoarthritis-and-intact-rotator-cuff
#20
Edward G McFarland, Gazi Huri, Yoon Suk Hyun, Steve A Petersen, Uma Srikumaran
BACKGROUND: Treating shoulders with osteoarthritis, an intact rotator cuff, and substantial glenoid bone loss is challenging. One option is reaming the glenoid flat and inserting a reverse prosthesis. This study reports the subjective, objective, and radiographic results of reverse total shoulder arthroplasty (RTSA) in this population. METHODS: We retrospectively reviewed 42 consecutive patients (23 women; mean age, 71 years [range, 53 to 89 years]) with primary glenohumeral osteoarthritis, intact rotator cuffs, and Walch type-A2 (n = 19), B2 (n = 5), or C glenoids (n = 18) who had undergone a total of 42 RTSAs with glenoid reaming without bone-grafting between 2008 and 2013 (mean follow-up, 36 months [range, 24 to 66 months])...
November 2, 2016: Journal of Bone and Joint Surgery. American Volume
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