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A2 Surgery

Yair Rubinstein, Chen Weiner, Adi Einan-Lifshitz, Noa Chetrit, Nadav Shoshany, David Zadok, Isaac Avni, Eran Pras
PURPOSE: This study reports the presentation of 2 families with macular corneal dystrophy (MCD). The aim of this study was to show whether ultrasound biomicroscopy (UBM) can, based on posterior changes of the cornea in MCD, assist in the choice of surgery, either anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK), compared with optical coherence tomography (OCT) and Scheimpflug. METHODS: Six patients with MCD were examined for their best-corrected visual acuity, slit-lamp, OCT, UBM, and Scheimpflug findings...
October 14, 2016: Cornea
Eamon P Mulvaney, Christine Shilling, Sarah B Eivers, Antoinette S Perry, Anders Bjartell, Elaine W Kay, R William Watson, B Therese Kinsella
The prostanoid thromboxane (TX)A2 plays a central role in haemostasis and is increasingly implicated in cancer progression. TXA2 signals through two T Prostanoid receptor (TP) isoforms termed TPα and TPβ, with both encoded by the TBXA2R gene. Despite exhibiting several functional and regulatory differences, the role of the individual TP isoforms in neoplastic diseases is largely unknown.This study evaluated expression of the TPα and TPβ isoforms in tumour microarrays of the benign prostate and different pathological (Gleason) grades of prostate cancer (PCa)...
September 26, 2016: Oncotarget
M Xia, N-N Ji, M-L Duan, J-H Tong, J-G Xu, Y-M Zhang, S-H Wang
OBJECTIVE: Breast cancer is one of the most aggressive and pervasive cancers identified in females. Dexmedetomidine (Dex) is an efficient anesthetic used in surgery. Our study aimed to explore the role of Dex in the malignancy of breast cancer cells in vitro and in vivo. Further, we investigate the molecular mechanism involved in the function of Dex on breast cancer cells. MATERIALS AND METHODS: The methyl thiazolyl tetrazolium (MTT) assay was applied to detect cell proliferation...
August 2016: European Review for Medical and Pharmacological Sciences
Yann Philippe Charles, Axel Walter, Sébastien Schuller, Jean-Paul Steib
STUDY DESIGN: Prospective clinical trial in thoracolumbar trauma with 5-year follow-up. OBJECTIVE: To analyze clinical and radiographic outcomes of minimal invasive surgery, and the rational of circumferential fracture treatment with regard to age, degenerative changes, bone mineral density and global sagittal balance. SUMMARY OF BACKGROUND DATA: Non-neurologic fractures with anterior column defect can be treated by posterior percutaneous instrumentation and selective anterior fusion...
August 31, 2016: Spine
Ingo Mecklenburg, Wulf Sienel, Severin Schmid, Bernward Passlick, Peter Kufer
PURPOSE: Quantitative measurement of minimal residual disease (MRD) predicting recurrence in individual cancer patients is available only in very few indications such as acute lymphoblastic leukemia but is still missing in most solid tumors including non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: MAGE-A expression levels in blood and bone marrow determined as calibrator normalized relative ratios by quantitative multimarker real-time RT-PCR for transcript amplification of MAGE-A1, -A2, -A3/6, -A4, -A10 and -A12 in 94 patients with completely resected NSCLC were correlated with survival in a clinical study...
August 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Z Q Bao, D Fang, C B Yue, L Cai, T Y Wang, X S Li, L Q Zhou
OBJECTIVE: To investigate the clinical characteristics, treatment and prognosis of primary penoscrotal extra-mammary Paget's disease (PSPD). METHODS: The clinical and pathological data of 22 cases of primary PSPD were retrospectively reviewed. Survival rate of the overall patients, the invasive patients, and the patients with positive surgical margin or negative surgical margin were analyzed with Kaplan-Meier survival curve method. RESULTS: Among all the patients with primary PSPD, the median age of onset was 64...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
V Caiaffa, G Vicenti, C Mori, A Panella, V Conserva, G Corina, L Scialpi, A Abate, M Carrozzo, Leonardo Petrelli, G Picca, A Aloisi, G Rollo, M Filipponi, V Freda, A Pansini, A Puce, G Solarino, B Moretti
We investigated whether a proximal femoral nail can be implanted without a distal locking screw in AO/OTA 31-A1 and 31-A2 pertrochanteric stable femur fractures. A multicentre, randomised study was conducted in six level-two trauma centres in our area (Puglia, Italy). A total of 333 patients received their allocated intervention (162 in the locking group [LG] and 171 in the unlocking group [UG]) and 266 patients were included in the final analysis at 1year. Our data showed no statistically significant difference between the two groups at 1-year follow-up for ability to walk, SF-36 questionnaire results, residual pain (visual analogue scale [VAS] score) and level of overall satisfaction...
August 11, 2016: Injury
S Novella, X Vidal-Gómez, A Mompeón, D Pérez-Cremades, G Segarra, P Medina, C Hermenegildo
OBJECTIVE: The role of ageing in the development of vascular disease is currently associated with a rise in oxidative stress. Thromboxane A2 (TXA2) is an inflammatory and oxidant endogenous vasoconstrictor which action increases with ageing and lack of estrogens, both conditions found in menopause. Our aim was to determine superoxide anion (O2-) levels in response to TXA2 in aortic vascular tissue from senescent and ovariectomized mice and the role of cyclooxygenase as source of O2-. DESIGN AND METHOD: Senescence accelerated mice (SAM) were used in this study...
September 2016: Journal of Hypertension
Marco Caforio, Pietro Maniscalco, Massimiliano Colombo, Giorgio Maria Calori
INTRODUCTION: Proximal humeral fractures with a spiral line of fracture extending from the humeral head to the diaphyseal region are increasing. Treatment for these fractures is comparable to that for shaft fractures. The purpose of this study was to evaluate the use of a new "Long" humeral nail for this type of lesion and identify the best distal locking. MATERIALS AND METHODS: Forty-three patients treated with a Long Diphos Nail(®) were selected for this study: main exclusion criteria were poor cognitive and responsive ability to physical therapy, four-part fracture requiring humeral head replacement, an isolated greater or lesser tubercle fracture and a head-splitting fracture...
August 6, 2016: Injury
X Li, W M Kong, C Han, Z Yan, H Zhao, W Y Zhang, J D Wang
OBJECTIVE: To compare the clinical efficacy of different treatments based on radical surgery in stage Ⅰ b2 and Ⅱ a2 cervical cancer through prospective randomized controlled study. METHODS: A total of 133 patients with stage Ⅰ b2 and Ⅱ a2 cervical cancer treated at Beijing Obstetrics and Gynecology Hospital of Capital Medical University during January 2009 to December 2012 were enrolled and randomly assigned to receive one of the following three treatments: preoperative intracavitary irradiation(PII)group, radical hysterectomy(RH)group, and neoadjuvant chemotherapy(NACT)group...
July 25, 2016: Zhonghua Fu Chan Ke za Zhi
Bin Ye, Ming Yan, Huiyang Zhu, Wei Duan, Xueyu Hu, Zhengxu Ye, Zhuojing Luo
STUDY DESIGN: A biomechanical study. OBJECTIVE: To study the different biomechanical property among fixed-axis, monoplanar and polyaxial screws in the static and dynamic tests. SUMMARY OF BACKGROUND DATA: Correction loss is a common phenomenon in the patients with thoracolumbar vertebral fractures who underwent the posterior pedicle screw fixation. The incidence varies with the kinds of fixation instrumentation used. There is higher incidence in polyaxial pedicle screws group than in fixed-axis pedicle screws...
July 22, 2016: Spine
Klemens Trieb
: The treatment of metacarpophalangeal destruction by rheumatoid arthritis is often an indication for joint replacement, here the swanson spacer still has his place. The flexible spacer may be implanted with or without titanium guide sleeves ("grommets"). However, the imaginary abrasion protection for the silicone grommets may in turn lead through micro-movements to wear as it is observed in the case shown here. PATIENTS AND METHODS: One over a period of 30 years suffering from rheumatoid arthritis 69 years old female patient is presented...
July 8, 2016: Current Rheumatology Reviews
Martin A Weinstock, Laura K Ferris, Melissa I Saul, Alan C Geller, Patricia M Risica, Julia A Siegel, Francis X Solano, John M Kirkwood
BACKGROUND: Population-based screening for the early detection of melanoma holds great promise for reducing melanoma mortality, but evidence is needed to determine whether benefits outweigh risks. Skin surgeries and dermatology visits after screening were assessed to indicate potential physical, psychological, and financial consequences. METHODS: Targeted primary care providers (PCPs) at the University of Pittsburgh Medical Center were trained to detect early melanoma using the INFORMED (INternet course FOR Melanoma Early Detection) program...
July 8, 2016: Cancer
Y X Sun, Q Liu, K J Liu, P Q Li, Z J Hu
OBJECTIVE: To explore the outcomes of the oncology, the fertility and pregnancy on patients with early-stage cervical cancer after undergoing fertility-sparing treatments, and to investigate its value on clinical treatment. METHODS: A total of 29 patients with cervical cancer (stage Ⅰa2-Ⅰb1) who had undergone the fertility- sparing treatments in Renji Hospital, School of Medicine, Shanghai Jiaotong University from February 2010 to September 2015 were analyzed retrospectively...
June 25, 2016: Zhonghua Fu Chan Ke za Zhi
Hassan Hashemi, Soheila Asgari, Mahdi Mortazavi, Reza Ghaffari
OBJECTIVE: To compare the effect of femtosecond-assisted thin flap laser-assisted in situ keratomileusis (FS-LASIK) and photorefractive keratectomy with mitomycin-C (PRK-MMC) in highly myopic patients (>7.0 D [D]) on corneal biomechanical parameters. METHODS: In this prospective comparative interventional case series, 60 patients (30 patients in each group) with a manifest refractive spherical equivalent (MRSE) greater than 7.0 D were enrolled. Corvis ST parameters were measured before and at 3 and 6 months postoperatively...
May 26, 2016: Eye & Contact Lens
K Cilliers, B J Page
Anomalies of the anterior cerebral artery (ACA) include the median ACA (MedACA), bihemispheric ACA (BihemACA) and the azygos ACA. Knowledge of these anomalies can be crucial to clinicians and neurosurgeons, especially during surgeries involving the interhemispheric region and in the interpretation of the clinical signs of a stroke. Since few reports exist on the origin, area supplied, diameter and length of the ACA anomalies, the aim of this study is to give a detailed description on the anatomy of the ACA anomalies...
May 26, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
J-D Chang, I-S Kim, S-S Lee, J-H Yoo, J-H Hwang
BACKGROUND: While hemiarthroplasty (HA) is considered the treatment of choice for displaced femoral neck (FN) fractures in elderly patients, HA has been partly performed as an alternative treatment option for unstable intertrochanteric (IT) fractures. However, there is a paucity of data regarding the risk and availability of HA for unstable IT fractures compared to HA for displaced FN fractures in elderly patients. Therefore, we performed this case-control study to determine whether HA for unstable IT fractures provides clinical results and survival comparable to HA for displaced FN fractures in elderly patients...
October 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Tjebbe Hagenaars, Guido W Van Oijen, W Herbert Roerdink, Paul A Vegt, Jos P A M Vroemen, Michael H J Verhofstad, Esther M M Van Lieshout
BACKGROUND: Approximately 17 % of all fractures involve the distal radius. Two-thirds require reduction due to displacement. High redislocation rates and functional disability remain a significant problem after non-operative treatment, with up to 30 % of patients suffering long-term functional restrictions. Whether operative correction is superior to non-operative treatment with respect to functional outcome has not unequivocally been confirmed. The IlluminOss® System was introduced in 2009 as a novel, patient-specific, and minimally invasive intramedullary fracture fixation...
2016: BMC Musculoskeletal Disorders
Gholam Hossein Kazemian, Mohammad Emami, Alireza Manafi, Farideh Najafi, Mohammad Amin Najafi
BACKGROUND: Hip fractures are one of the causes of disability amongst elderly patients. External fixator and skeletal traction are two modes of treatment. OBJECTIVES: The aim of this study is to compare two different treatment modes for intertrochanteric fractures in elderly patients. PATIENTS AND METHODS: Sixty elderly patients with intertrochanteric fractures were randomized for treatment with either skeletal traction (Group A) or an external fixation (Group B)...
February 2016: Trauma Monthly
Girish H Vasanad, S M Antin, R C Akkimaradi, Prasad Policepatil, Girish Naikawadi
INTRODUCTION: Lower tibial extra-articular fractures of lower tibial extra-articular bone, treated with Minimally Invasive Percutaneous plate osteosynthesis (MIPPO) may have certain advantages, though the modiality is technically demanding. AIM: To assess the results of distal tibial fractures treated with minimally invasive plate osteosynthesis utilizing precontoured dital medial tibial locking plates without fibular fracture fixation. MATERIAL AND METHODS: The study was conducted during the period from june 2009 to june 2011...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
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