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JOURNAL ARTICLE
Barbara Van Noppen, Sean Sassano-Higgins, Raghu Appasani, Felicity Sapp
In this update of a previous review, the authors discuss cognitive-behavioral therapy (CBT) with exposure and response prevention for obsessive-compulsive disorder (OCD). This efficacious modality avoids side effects common to psychotropic medication and reduces risk of relapse once treatment has ended. Psychotherapy involves identification and ranking of stimuli that provoke obsessions, exposure to these stimuli while preventing compulsions, and cognitive restructuring. The family of the OCD patient plays a significant role in treatment...
October 2021: Focus: Journal of Life Long Learning in Psychiatry
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JOURNAL ARTICLE
Emiel Vanhulle, Joren Stroobants, Becky Provinciael, Anita Camps, Sam Noppen, Piet Maes, Kurt Vermeire
Despite the great success of the administered vaccines against SARS-CoV-2, the virus can still spread, as evidenced by the current circulation of the highly contagious Omicron variant. This emphasizes the additional need to develop effective antiviral countermeasures. In the context of early preclinical studies for antiviral assessment, robust cellular infection systems are required to screen drug libraries. In this study, we reported the implementation of a human glioblastoma cell line, stably expressing ACE2, in a SARS-CoV-2 cytopathic effect (CPE) reduction assay...
May 17, 2022: Antiviral Research
#23
JOURNAL ARTICLE
Olaia Martí-Marí, Belén Martínez-Gualda, Irene Fernández-Barahona, Alberto Mills, Rana Abdelnabi, Sam Noppen, Johan Neyts, Dominique Schols, María-José Camarasa, Fernando Herranz, Federico Gago, Ana San-Félix
We have recently described a novel family of compounds of reduced size and dual anti-HIV and anti-EV71 activity that encompasses tripodal and tetrapodal derivatives. The tripodal prototype, AL-470, has a nitro group at the focal point of the central scaffold and three attached tryptophan residues, each of which bearing an isophthaloyl moiety at the C2 position of the indole ring. A nitro to amino substitution has allowed us now to introduce a chemically addressable functionality to perform further structural modifications consisting of both direct and linker-mediated attachment of several aromatic groups, including the fluorescent dye Alexa Fluor 647 and the antibody-recruiting 2,4-dinitrophenyl motif...
April 27, 2022: European Journal of Medicinal Chemistry
#24
JOURNAL ARTICLE
Antonios Fikatas, Jonas Dehairs, Sam Noppen, Jordi Doijen, Frank Vanderhoydonc, Eef Meyen, Johannes V Swinnen, Christophe Pannecouque, Dominique Schols
To date, no vaccines or antivirals are available against Zika virus (ZIKV). In addition, the mechanisms underlying ZIKV-associated pathogenesis of the central nervous system (CNS) are largely unexplored. Getting more insight into the cellular pathways that ZIKV recruits to facilitate infection of susceptible cells will be crucial for establishing an effective treatment strategy. In general, cells secrete a number of vesicles, known as extracellular vesicles (EVs), in response to viral infections. These EVs serve as intercellular communicators...
November 25, 2021: Viruses
#25
JOURNAL ARTICLE
Lisa Goudman, Ann De Smedt, Marc Noppen, Maarten Moens
Patients recovered from a COVID-19 infection often report vague symptoms of fatigue or dyspnoea, comparable to the manifestations in patients with central sensitisation. The hypothesis was that central sensitisation could be the underlying common aetiology in both patient populations. This study explored the presence of symptoms of central sensitisation, and the association with functional status and health-related quality of life, in patients post COVID-19 infection. Patients who were previously infected with COVID-19 filled out the Central Sensitisation Inventory (CSI), the Post-COVID-19 Functional Status (PCFS) Scale and the EuroQol with five dimensions, through an online survey...
November 28, 2021: Journal of Clinical Medicine
#26
JOURNAL ARTICLE
Hendrik Possemiers, Thao-Thy Pham, Marion Coens, Emilie Pollenus, Sofie Knoops, Sam Noppen, Leen Vandermosten, Sigrid D'haese, Luna Dillemans, Fran Prenen, Dominique Schols, Blandine Franke-Fayard, Philippe E Van den Steen
Malaria is a hazardous disease caused by Plasmodium parasites and often results in lethal complications, including malaria-associated acute respiratory distress syndrome (MA-ARDS). Parasite sequestration in the microvasculature is often observed, but its role in malaria pathogenesis and complications is still incompletely understood. We used skeleton binding protein-1 (SBP-1) KO parasites to study the role of sequestration in experimental MA-ARDS. The sequestration-deficiency of these SBP-1 KO parasites was confirmed with bioluminescence imaging and by measuring parasite accumulation in the lungs with RT-qPCR...
November 29, 2021: PLoS Pathogens
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JOURNAL ARTICLE
Lisa Goudman, Ann De Smedt, René Huygens, Marc Noppen, Maria Vanschoenwinkel, Samar M Hatem, Maarten Moens
Continuous Intrathecal Drug Delivery through an implanted pump is a well-known therapeutic option for the management of chronic pain and severe disabling spasticity. To have a successful therapy, pump refills need to be performed at regular time intervals after implantation. In line with the increased applications of Hospital at Home, these refill procedures might be performed at the patient's home. The aim of this pilot study is to evaluate the feasibility, safety, and effectiveness of intrathecal pump refill procedures at home...
November 17, 2021: Journal of Clinical Medicine
#28
JOURNAL ARTICLE
Nicolas Maréchal, Stefaan Six, Eveline Clemmen, Catherine Baillon, Annelien Tack, Sabien Bauwens, Marc Noppen, Willem Distelmans, Ingo Beyer, Johan Bilsen
Background: Palliative sedation requires no formal registration in Belgium. For euthanasia, however, there are clear guidelines in certain countries, including mandatory registration and evaluation of cases. Official guidelines have been developed for palliative sedation, but research still shows unskilled use of sedation and unclear demarcation between palliative sedation and euthanasia. Registration could be used to avoid unskilled use of sedation and to avoid use or abuse of sedation to hasten the patient's death (described as "slow/passive euthanasia")...
November 9, 2021: Journal of Palliative Medicine
#29
Christoph Driessen, Christoph Noppen, Georg Boonen, Juergen Drewe
Low-dose interferon-α 2a treatment may be considered as an alternative to cytoreductive therapy with hydroxyurea or regularly dosed interferon in high-risk polycythemia vera patients.
October 2021: Clinical Case Reports
#30
JOURNAL ARTICLE
Ana M Abrantes, Donnell Van Noppen, Genie Bailey, Lisa A Uebelacker, Matthew Buman, Michael D Stein
Purpose: While methadone maintenance treatment (MMT) has been effective in improving opioid use outcomes, most patients continue to engage in unhealthy lifestyles that lead to significant mental and physical health consequences. Interventions targeting increases in physical activity (PA) in MMT patients could have a significant impact on reducing the overall morbidity in these individuals. The purpose of this study was to assess acceptability and feasibility of a 12-week peer-facilitated PA intervention for MMT patients called TREC (Transforming Recovery with Exercise and Community)...
October 2021: Mental Health and Physical Activity
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JOURNAL ARTICLE
Chaoran Chen, Sarah Ann Nadeau, Ivan Topolsky, Marc Manceau, Jana S Huisman, Kim Philipp Jablonski, Lara Fuhrmann, David Dreifuss, Katharina Jahn, Christiane Beckmann, Maurice Redondo, Christoph Noppen, Lorenz Risch, Martin Risch, Nadia Wohlwend, Sinem Kas, Thomas Bodmer, Tim Roloff, Madlen Stange, Adrian Egli, Isabella Eckerle, Laurent Kaiser, Rebecca Denes, Mirjam Feldkamp, Ina Nissen, Natascha Santacroce, Elodie Burcklen, Catharine Aquino, Andreia Cabral de Gouvea, Maria Domenica Moccia, Simon Grüter, Timothy Sykes, Lennart Opitz, Griffin White, Laura Neff, Doris Popovic, Andrea Patrignani, Jay Tracy, Ralph Schlapbach, Emmanouil T Dermitzakis, Keith Harshman, Ioannis Xenarios, Henri Pegeot, Lorenzo Cerutti, Deborah Penet, Anthony Blin, Melyssa Elies, Christian L Althaus, Christian Beisel, Niko Beerenwinkel, Martin Ackermann, Tanja Stadler
BACKGROUND: In December 2020, the United Kingdom (UK) reported a SARS-CoV-2 Variant of Concern (VoC) which is now named B.1.1.7. Based on initial data from the UK and later data from other countries, this variant was estimated to have a transmission fitness advantage of around 40-80 % (Volz et al., 2021; Leung et al., 2021; Davies et al., 2021). AIM: This study aims to estimate the transmission fitness advantage and the effective reproductive number of B.1.1.7 through time based on data from Switzerland...
August 9, 2021: Epidemics
#32
JOURNAL ARTICLE
Marc Vanhove, Jean-Marc Wagner, Bernard Noppen, Bart Jonckx, Elke Vermassen, Alan W Stitt
Intravitreal (IVT) injection remains the preferred administration route of pharmacological agents intended for the treatment of back of the eye diseases such as diabetic macular edema (DME) and neovascular age-related macular degeneration (nvAMD). The procedure enables drugs to be delivered locally at high concentrations whilst limiting whole body exposure and associated risk of systemic adverse events. Nevertheless, intravitreally-delivered drugs do enter the general circulation and achieving an accurate understanding of systemic exposure is pivotal for the evaluation and development of drugs administered in the eye...
July 23, 2021: Journal of Pharmacokinetics and Pharmacodynamics
#33
JOURNAL ARTICLE
Marc Vanhove, Bernard Noppen, Jean-Marc Wagner, Tine Van Bergen, Philippe Barbeaux, Alan W Stitt
Intravitreal (IVT) injection of pharmacological agents is an established and widely used procedure for the treatment of many posterior segment of the eye diseases. IVT injections permit drugs to reach high concentrations in the retina whilst limiting systemic exposure. Beyond the risk of secondary complications such as intraocular infection, the potential of systemic adverse events cannot be neglected. Therefore, a detailed understanding of the rules governing systemic exposure following IVT drug administration remains a prerequisite for the evaluation and development of new pharmacological agents intended for eye delivery...
July 23, 2021: Journal of Pharmacokinetics and Pharmacodynamics
#34
JOURNAL ARTICLE
Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Vasily Rybakin, Sam Noppen, Melissa R Stas, Eline Bernaerts, Eva Ganseman, Mieke Metzemaekers, Dominique Schols, Paul Proost, Ghislain Opdenakker
Interleukin 7 (IL-7) is a cell growth factor with a central role in normal T cell development, survival and differentiation. The lack of IL-7-IL-7 receptor(R)-mediated signaling compromises lymphoid development, whereas increased signaling activity contributes to the development of chronic inflammation, cancer and autoimmunity. Gain-of-function alterations of the IL-7R and the signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) are enriched in T cell acute lymphoblastic leukemia (T-ALL) and autocrine production of IL-7 by T-ALL cells is involved in the phenotypes of leukemic initiation and oncogenic spreading...
2021: Frontiers in Immunology
#35
JOURNAL ARTICLE
Merel Oeyen, Eef Meyen, Sam Noppen, Sandra Claes, Jordi Doijen, Kurt Vermeire, Roderich D Süssmuth, Dominique Schols
To date, there are no broad-spectrum antivirals available to treat infections with flaviviruses such as dengue (DENV) and Zika virus (ZIKV). In this study, we determine the broad antiviral activity of the lantibiotic Labyrinthopeptin A1. We show that Laby A1 inhibits all DENV serotypes and various ZIKV strains with IC50 around 1 μM. The structurally related Laby A2 also displayed a consistent, but about tenfold lower, antiviral activity. Furthermore, Laby A1 inhibits many viruses from divergent families such as HIV, YFV, RSV and Punta Torovirus...
July 10, 2021: Virology
#36
JOURNAL ARTICLE
Debbie Sookman, Katharine A Phillips, Gideon E Anholt, Sunil Bhar, Victoria Bream, Fiona L Challacombe, Anna Coughtrey, Michelle G Craske, Edna Foa, Jean-Philippe Gagné, Jonathan D Huppert, David Jacobi, Karina Lovell, Carmen P McLean, Fugen Neziroglu, Rebecca Pedley, Sean Perrin, Anthony Pinto, C Alec Pollard, Adam S Radomsky, Bradley C Riemann, Roz Shafran, Gregoris Simos, Ingrid Söchting, Laura J Summerfeldt, Jeff Szymanski, Michael Treanor, Barbara Van Noppen, Patricia van Oppen, Maureen Whittal, Monnica T Williams, Timothy Williams, Elna Yadin, David Veale
Obsessive-Compulsive Disorder (OCD) is a leading cause of disability world-wide (World Health Organization, 2008). Treatment of OCD is a specialized field whose aim is recovery from illness for as many patients as possible. The evidence-based psychotherapeutic treatment for OCD is specialized cognitive behavior therapy (CBT, NICE, 2005, Koran and Simpson, 2013). However, these treatments are not accessible to many sufferers around the world. Currently available guidelines for care are deemed to be essential but insufficient because of highly variable clinician knowledge and competencies specific to OCD...
January 27, 2021: Psychiatry Research
#37
JOURNAL ARTICLE
Malcom Howard, Ruediger Noppens, Nelson Gonzalez, Philip M Jones, Sonja M Payne
PURPOSE: Numerous clinical guidelines are available for management of the unanticipated difficult airway. It is unclear if practice recommendations are endorsed on regional, local, or individual levels. The objective of this observational study was to examine local and regional use of airway guidelines by anesthesiologists within a hospital partnership in Southwestern Ontario. METHODS: Using a paper survey, distributed locally to consultant and trainee anesthesiologists in a tertiary hospital, we examined individual clinical and educational practices regarding guideline use in airway management...
September 2021: Canadian Journal of Anaesthesia
#38
JOURNAL ARTICLE
Olaia Martí-Marí, Belén Martínez-Gualda, Sofía de la Puente-Secades, Alberto Mills, Ernesto Quesada, Rana Abdelnabi, Liang Sun, Arnaud Boonen, Sam Noppen, Johan Neyts, Dominique Schols, María-José Camarasa, Federico Gago, Ana San-Félix
We have recently described a new generation of potent human immunodeficiency virus (HIV) and EV-A71 entry inhibitors. The prototypes contain three or four tryptophan (Trp) residues bearing an isophthalic acid moiety at the C2 position of each side-chain indole ring. This work is now extended by both shifting the position of the isophthalic acid to C7 and synthesizing doubly arylated C2/C7 derivatives. The most potent derivative (50% effective concentration (EC50 ) HIV-1, 6 nM; EC50 EV-A71, 40 nM), 33 ( AL-518 ), is a C2/C7 doubly arylated tetrapodal compound...
July 7, 2021: Journal of Medicinal Chemistry
#39
JOURNAL ARTICLE
Bernard Noppen, Anouk Vanbelle, Alan W Stitt, Marc Vanhove
Selection of pharmacological agents based on potency measurements performed at equilibrium fail to incorporate the kinetic aspects of the drug-target interaction. Here we describe a method for screening or characterization of enzyme inhibitors that allows the concomitant determination of the equilibrium inhibition constant in unison with rates of complex formation and dissociation. The assay is distinct from conventional enzymatic assays and is based on the analysis of inhibition curves recorded prior to full equilibration of the system...
June 22, 2021: European Biophysics Journal: EBJ
#40
JOURNAL ARTICLE
J Adam Law, Laura V Duggan, Mathieu Asselin, Paul Baker, Edward Crosby, Andrew Downey, Orlando R Hung, Philip M Jones, François Lemay, Rudiger Noppens, Matteo Parotto, Roanne Preston, Nick Sowers, Kathryn Sparrow, Timothy P Turkstra, David T Wong, George Kovacs
PURPOSE: Since the last Canadian Airway Focus Group (CAFG) guidelines were published in 2013, the literature on airway management has expanded substantially. The CAFG therefore re-convened to examine this literature and update practice recommendations. This first of two articles addresses difficulty encountered with airway management in an unconscious patient. SOURCE: Canadian Airway Focus Group members, including anesthesia, emergency medicine, and critical care physicians, were assigned topics to search...
September 2021: Canadian Journal of Anaesthesia
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