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JOURNAL ARTICLE
Malcolm F Howard, Ruediger R Noppens
No abstract text is available yet for this article.
April 9, 2024: Canadian Journal of Anaesthesia
#2
Malcolm Howard, Ruediger Noppens, Nelson Gonzalez, Philip M Jones, Sonja M Payne
No abstract text is available yet for this article.
March 26, 2024: Canadian Journal of Anaesthesia
#3
JOURNAL ARTICLE
Luna Dillemans, Karen Yu, Alexandra De Zutter, Sam Noppen, Mieke Gouwy, Nele Berghmans, Lisa Verhallen, Mirre De Bondt, Lotte Vanbrabant, Stef Brusselmans, Erik Martens, Dominique Schols, Patrick Verschueren, Mette M Rosenkilde, Pedro Elias Marques, Sofie Struyf, Paul Proost
BACKGROUND: Interferon-γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-coupled receptor (GPCR), CXC chemokine receptor 3 (CXCR3). As a consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural and functional heterogeneity. However, the biological effect of natural posttranslational processing of CXCL10 at the carboxy (C)-terminus has remained partially elusive...
February 2, 2024: Cell Communication and Signaling: CCS
#4
JOURNAL ARTICLE
Lisa A Uebelacker, Tosca D Braun, Lynn E Taylor, Robert Saper, Marielle Baldwi, Ana Abrantes, Geoffrey Tremont, Alisha Toribio, Shannon Kirshy, Ryan Koch, Lucy Lorin, Donnell Van Noppen, Bradley Anderson, Eric J Roseen, Michael D Stein
BACKGROUND: Chronic pain affects up to half of individuals taking opioid agonist therapy (OAT; i.e., methadone and buprenorphine) for opioid use disorder (OUD), and yoga-based interventions may be useful for decreasing pain-related disability. Whereas more yoga practice (i.e., higher "dosage") may improve pain-related outcomes, it can be challenging for people with chronic pain taking OAT to attend class regularly and sustain a regular personal yoga practice. Therefore, we plan to optimize a yoga-based intervention (YBI) package in order to support class attendance and personal practice, thus maximizing the yoga dose received...
December 14, 2023: Contemporary Clinical Trials
#5
JOURNAL ARTICLE
Ruediger R Noppens, Farzad Izaddoust Dar, Sujoy Banik
PURPOSE: Memsorb™ is a novel device for carbon dioxide (CO2 ) removal from anesthesia circuits via a semipermeable polymeric membrane. We evaluated the performance of the memsorb device for the removal of CO2 in an Aisys™ CS2 machine and compared it with a standard chemical granulate absorber (CGA) using a high-fidelity lung simulator. METHODS: We used an in vitro lung simulator (DUCt) to control CO2 release by imitating alveolar gas exchange. The ventilator settings were identical for all measurements...
September 11, 2023: Canadian Journal of Anaesthesia
#6
JOURNAL ARTICLE
Evelien Vanderlinden, Arnaud Boonen, Sam Noppen, Geert Schoofs, Maya Imbrechts, Nick Geukens, Robert Snoeck, Annelies Stevaert, Lieve Naesens, Graciela Andrei, Dominique Schols
Here, we report on the anti-SARS-CoV-2 activity of PRO-2000, a sulfonated polyanionic compound. In Vero cells infected with the Wuhan, alpha, beta, delta or omicron variant, PRO-2000 displayed EC50 values of 1.1 μM, 2.4 μM, 1.3 μM, 2.1 μM and 0.11 μM, respectively, and an average selectivity index (i.e. ratio of cytotoxic versus antiviral concentration) of 172. Its anti-SARS-CoV-2 activity was confirmed by virus yield assays in Vero cells, Caco2 cells and A549 cells overexpressing ACE2 and TMPRSS2 (A549-AT)...
August 9, 2023: Antiviral Research
#7
JOURNAL ARTICLE
M Kriege, T Turkstra, R Noppens
No abstract text is available yet for this article.
July 14, 2023: Anaesthesia
#8
JOURNAL ARTICLE
Laura Rué, Tom Jaspers, Isabelle M S Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases. Unfortunately, most of the biologicals do not reach their brain targets in sufficient quantities. The antibody targeting of receptor-mediated transcytosis (RMT) receptors is an exploited mechanism that increases brain permeability. We previously discovered an anti-human transferrin receptor (TfR) nanobody that could efficiently deliver a therapeutic moiety across the BBB...
June 16, 2023: Pharmaceutics
#9
JOURNAL ARTICLE
Kelly Bugatti, Andrea Sartori, Lucia Battistini, Crescenzo Coppa, Emiel Vanhulle, Sam Noppen, Becky Provinciael, Lieve Naesens, Annelies Stevaert, Alessandro Contini, Kurt Vermeire, Franca Zanardi
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safe anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike (S) protein of SARS-CoV-2 to prevent its attachment to the cellular receptor ACE2. Here, we exploited the core structure of polymyxin B, a naturally occurring antibiotic, to design and synthesize unprecedented peptidomimetics (PMs), intended to target contemporarily two defined, non-overlapping regions of the S receptor-binding domain (RBD)...
May 15, 2023: International Journal of Molecular Sciences
#10
JOURNAL ARTICLE
Andrew M Bysice, Tyler Oswald, Luis E Mendoza Vasquez, Francisco Laxague, M Elise Graham, Ruediger Noppens, Kevin Fung
OBJECTIVE: Airway fires are a rare but devastating complication of airway surgery. Although protocols for managing airway fires have been discussed, the ideal conditions for igniting airway fires remain unclear. This study examined the oxygen level required to ignite a fire during a tracheostomy. STUDY DESIGN: Porcine Model. SETTING: Laboratory. METHODS: Porcine tracheas were intubated with a 7.5 air-filled polyvinyl endotracheal tube...
2023: OTO Open
#11
JOURNAL ARTICLE
Emiel Vanhulle, Jordi Doijen, Joren Stroobants, Becky Provinciael, Sam Noppen, Dominique Schols, Annelies Stevaert, Kurt Vermeire
Despite the vaccination campaigns for COVID-19, we still cannot control the spread of SARS-CoV-2, as evidenced by the ongoing circulation of the Omicron variants of concern. This highlights the need for broad-spectrum antivirals to further combat COVID-19 and to be prepared for a new pandemic with a (re-)emerging coronavirus. An interesting target for antiviral drug development is the fusion of the viral envelope with host cell membranes, a crucial early step in the replication cycle of coronaviruses. In this study, we explored the use of cellular electrical impedance (CEI) to quantitatively monitor morphological changes in real time, resulting from cell-cell fusion elicited by SARS-CoV-2 spike...
March 26, 2023: Antiviral Research
#12
RANDOMIZED CONTROLLED TRIAL
M Kriege, R R Noppens, T Turkstra, S Payne, O Kunitz, I Tzanova, I Schmidtmann
Before completion of this study, there was insufficient evidence demonstrating the superiority of videolaryngoscopy compared with direct laryngoscopy for elective tracheal intubation. We hypothesised that using videolaryngoscopy for routine tracheal intubation would result in higher first-pass tracheal intubation success compared with direct laryngoscopy. In this multicentre randomised trial, 2092 adult patients without predicted difficult airway requiring tracheal intubation for elective surgery were allocated randomly to either videolaryngoscopy with a Macintosh blade (McGrath™) or direct laryngoscopy...
June 2023: Anaesthesia
#13
JOURNAL ARTICLE
Jolien Breukers, Karen Ven, Caroline Struyfs, Louanne Ampofo, Iene Rutten, Maya Imbrechts, Francesca Pollet, Julie Van Lent, Winnie Kerstens, Sam Noppen, Dominique Schols, Paul De Munter, Hendrik Jan Thibaut, Karen Vanhoorelbeke, Dragana Spasic, Paul Declerck, Bruno P A Cammue, Nick Geukens, Karin Thevissen, Jeroen Lammertyn
Advancements in lab-on-a-chip technologies have revolutionized the single-cell analysis field. However, an accessible platform for in-depth screening and specific retrieval of single cells, which moreover enables studying diverse cell types and performing various downstream analyses, is still lacking. As a solution, FLUIDOT is introduced, a versatile microfluidic platform incorporating customizable microwells, optical tweezers and an interchangeable cell-retrieval system. Thanks to its smart microfluidic design, FLUIDOT is straightforward to fabricate and operate, rendering the technology widely accessible...
January 15, 2023: Small Methods
#14
JOURNAL ARTICLE
Yasser Selim, Élise Di Lena, Nadia Safa, Sid Rahman, Pepa Kaneva, Liane Feldman, Nawaf Abu-Omar, Zarrukh Baig, Nathan Ginther, Dilip Gill, Zarrukh Baig, Zaini Sarwar, Carlos Verdiales, Mike Moser, Kevin Verhoeff, Valentin Mocanu, Breanna Fang, Jerry Dang, Warren Sun, Noah Switzer, Daniel Birch, Shahzeer Karmali, Julie La, Anood Alqaydi, Xuejiao Wei, Genevieve Digby, Susan Brogly, Shaila Merchant, Kieran Purich, Kevin Verhoeff, Alexander Miles, Janice Y Kung, A M James Shapiro, David L Bigam, Samantha Albacete, Ashlee Matkin, Danielle Dumestre, Lashan Peiris, Rahim Valji, Simon Turner, Kieran Purich, Kevin Verhoeff, Brett Mador, Steffane McLennan, Ali Safar, Atif Jastaniah, Morgan Schellenberg, Natthida Owattanapanich, Areg Grigorian, Lydia Lam, Jeffry Nahmias, Kenji Inaba, Morgan Schellenberg, Panagiotis Liasidis, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Elizabeth R Benjamin, Shaun Cowan, Natthida Owattanapanich, Monica D Wong, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Natthida Owattanapanich, Brent Emigh, Lindsey Karavites, Damon H Clark, Lydia Lam, Kenji Inaba, Morgan Schellenberg, Elizabeth R Benjamin, Natthida Owattanapanich, Kenji Inaba, Demetrios Demetriades, Morgan Schellenberg, Geoffrey A Anderson, Natthida Owattanapanich, Vincent Cheng, Lydia Lam, Kenji Inaba, Lee Myers, Julian Daza, Brian Cuthbertson, Paul Myles, Mark Shulman, Duminda Wijeysundera, Lyndsay T Glass, Patrick B Murphy, Laura Allen, Kathryn Minkhorst, Dillon Bowker, Ephraim S Tang, Kenneth Leslie, Jeffrey E Hawel, Kevin Verhoeff, Odelle Ma, Kieran Purich, Samuel Skinner, Raveena Dhaliwal, Matt Strickland, Garrett Johnson, Jason Park, Ashley Vergis, Lawrence Gillman, Justin Rivard, Keegan Guidolin, Justin Lin, Anudari Zorigtbaatar, Minahil Nadeem, Tarek Ibrahim, Zdenka Neilson, Kyung Young Peter Kim, Luckshi Rajendran, Sami Chadi, Fayez Quereshy, Lyndsay T Glass, Malcolm Davidson, Emily Friedrich, Caitlin Champion, Saba Balvardi, Koorosh Semsar-Kazerooni, Pepa Kaneva, Carmen Mueller, Melina Vassiliou, Mohammed Al Mahroos, Julio Fiore, Kevin Schwartzman, Liane Feldman, Nada Gawad, Kieran Purich, Kevin Verhoeff, Blaire Anderson, Tyler McKechnie, Ryan Daniel, Colin Kruse, Marc Levin, Yung Lee, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Christopher Povolo, Jay Lee, Yung Lee, Lily Park, Aristithes Doumouras, Dennis Hong, Mohit Bhandari, Cagla Eskicioglu, Kieran Purich, Esther Lee, Kevin Verhoeff, Dasan Sydora, Simon Turner, Matt Strickland, Jessica Henley, Darrell Boone, Stephanie Roberts, Emma Imbert, Duncan McGrouther, Paul Manuel, Christine Li, Mark Dykstra, Haili Wang, Ryan Snelgrove, Samuel Skinner, Kevin Verhoeff, Kieran Purich, Troy Perry, Matthew Strickland, Raveena Dhaliwal, Tori Lenet, Stephanie Skanes, Joseph Tropiano, Daniel McIsaac, Alan Tinmouth, Julie Hallet, Stuart Nicholls, Dean Fergusson, Guillaume Martel, Tori Lenet, Joseph Tropiano, Stephanie Skanes, Victoria Ivankovic, Daniel McIsaac, Alan Tinmouth, Andrea Patey, Dean Fergusson, Guillaume Martel, Jeff Metz, Reza Naqvi, Ruediger Noppens, Jeff Hawel, Ahmad Elnahas, Christopher Schlachta, Nawar Alkhamesi, Hilalion San Ahn, Tori Lenet, Richard Gilbert, Ranjeeta Mallick, Julie Shaw, Daniel McIsaac, Guillaume Martel, Uyen Do, Makena Pook, Tahereh Najafi, Fateme Rajabiyazdi, Charbel El-Kefraoui, Saba Balvardi, Natasha Barone, Hiba Elhaj, Philip Nguyen-Powanda, Lawrence Lee, Gabriele Baldini, Liane Feldman, Julio Fiore, Armin Rouhi, Kieran Purich, Uzair Jogiat, Deng Mapiour, Michael Kim, Brianna Greenberg, Ashlie Nadler, Hala Muaddi, Theres Stukel, Charles De Mestral, Avery Nathens, Stephen Pautler, Bobby Shayegan, Wael Hanna, Christopher Schlachta, Rodney Breau, Laura Hopkins, Timothy Jackson, Paul Karanicolas, Lily Park, Christopher Griffiths, Sam Ali, Victoria Archer, Zacharie Cloutier, Dexter Choi, Tyler McKechnie, Pablo Serrano, Kelly Vogt, J Andrew McClure, Philip Jones, Marko Mrkobrada, Suzanne Flier, Blayne Welk, Luc Dubois, Nori Bradley, Kosar Khwaja, Laura Allen, Lily Tung, Morad Hameed, Karina Spoyalo, Jacinthe Lampron, Carlos Garcia-Ochoa, Atif Jastaniah, Paul Engels, Gaurav Talwar, Zacharie Cloutier, Sam Minor, Brad Moffat, Neil Parry, Kelly Vogt, Shirley Xiaoxuan Deng, Tega Ebeye, Bree T Sharma, Anas Samman, Amna Zulfiqar, Roderick H Purzner, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Patrick Murphy, Laura Allen, Chad G Ball, Morad Hameed, Paul Engels, Rahima Nenshi, Sandy Widder, Sam Minor, Neil Parry, Nori Bradley, Brad Moffat, Kelly Vogt, Mostafa Alhabboubi, Sender Liberman, Evan Wong, Talat Chughtai, Joel Turner, Jessica Lie, Sam Wiseman, Jennifer Li, Nicole Mak, Simon Laplante, Babak Namazi, Parmiss Kiani, Daniel Hashimoto, Adnan Alseidi, Mauricio Pasten, L Michael Brunt, Sujata Gill, Brian Davis, Matthew Bloom, Luise Pernar, Allan Okrainec, Amin Madani, Jessica Lie, Trevor Hamilton, Kylie Nabata, Jenny W Zhang, Darren Zhao, Phil Dawe, Morad Hameed, Jeremy Drung, Laura Allen, Ken Leslie, Jeremy Drung, Thomas Nixon, Kieran Purich, Kevin Verhoeff, Samuel Skinner, Raveena Dhaliwal, Matt Strickland, Alexandra Allard-Coutu, Barbara Heller, Victoria Wright, Wanjae Cho, Michael Wong, Kevin Singh, Sarah Mansouri, Émilie Comeau, Yves Collin, Sonia Cheng Oviedo, Alex Lee, Luckshi Rajendran, Tyler Lamb, Morgann Reid, Anastasia Turner, Kimberly Bertens, Janelle Rekman, Fady Balaa, Jillian Tweedy, Katerina Neumann, Geoff Porter, Michael A D'Elia, Iris Teo, Catherine L Forse, Reilly Musselman, Brent Hopkins, Lily Grozman, Nawaf Alshawan, Shannon Fraser, Simon Bergman, Jean-Sebastien Pelletier, Tsafrir Vanounou, Evan G Wong, Ananya Srivastava, Brodie Nolan, Lyon Qiao, James Jung, Kameela Alibhai, Isabelle Raîche, Heather McDonald, Nada Gawad, Christina Lee, Rona Cheifetz, Philippa Hawley, Jeongyoon Jenny Moon, Zachary Rehany, Mehrshad Bakhshi, Tarek Razek, Jeremy Grushka, Nathalie Boulanger, Larry Watt, Alexandra Vivier, Greg Clark, Paola Fata, Dan Deckelbaum, Kosar Khwaja, Atif Jastaniah, Evan Wong, Nathan How, Kevin Ren, Yuan Qiu, Karyssa Hamann, Karina Spoyalo, Annie Lalande, Andrea MacNeill, Jason Park, Annie Lalande, Stephanie Alexis, Karina Spoyalo, Keiko Patterson, Neha Gadhari, Jiaying Zhao, Andrea MacNeill, Zarrukh Baig, Rubia Ahmed, Ameer Farooq, Ahmer Karimuddin, Christina Schweitzer, Sam Wiseman, Joshua Keogh, Allison Chhor, Housne Begum, Noori Akhtar-Danesh, Christian Finley, Bright Huo, Daria Manos, Zhaolin Xu, Kara Matheson, Samuel Chun, John Fris, Alison Wallace, Daniel French, Yogita S Patel, Jean-Marc Baste, Yaron Shargall, Thomas K Waddell, Kazuhiro Yasufuku, Tiago N Machuca, Feng Xie, Lehana Thabane, Wael C Hanna, Yogita S Patel, Marla K Beauchamp, Joshua Wald, Lawrence Mbuagbaw, Brenda L Key, Sheryl M Green, Wael C Hanna, Uzair Jogiat, Abdollah Behzadi, Laura Donahoe, Awrad Nasralla, Julius Poon, Najib Safieddine, Nazgol Seyednejad, Iran Tavakoli, Simon Turner, Anna L McGuire, Sohat Sharma, Roy A Hilzenrat, Melissa McConechy, Ingrid Frank, Curtis Hughsman, Stephen Yip, James J Choi, John Yee, Uzair Jogiat, Hannah Sasewich, Simon Turner, Vickie Baracos, Dean Eurich, Heather Filafilo, Eric Bedard, Yung Lee, Yasith Samarasinghe, Janhavi Patel, Adree Khondker, Tyler McKechnie, Nadeesha Samarasinghe, Christian Finley, Wael Hanna, Yaron Shargall, John Agzarian, Evan Barber, Melissa Whidden, Francisco Aguirre, Andrew Graham, Gileh-Gol Akhtar-Danesh, Allison Chhor, Housne Begum, Joycelyne Ewusie, Lawrence Mbuagbaw, Shargall Yaron, Adom Bondzi-Simpson, Melanie Keshishi, Yonas Ademe, Ayalew Tizazu, Marci Rose, Sameena Uddin, Michael Ko, Riley Bowker, Jimmy Ddamba, Daniel French, Alison Wallace, Negar Ahmadi, Najib Safieddine, Sayf Gazala, Carmine Simone, Sami A Abdul, Frances Wright, Christian Finley, Patrick J Villeneuve, Sebastian Gilbert, Sudhir Sundaresan, Andrew J E Seely, Donna E Maziak, Pooja Patel, Daria Manos, Alison Wallace, Madelaine Plourde, Lyndsay Harrison, Donna Turner, Jolie Ringash, Douglas Manuel, Biniam Kidane, Vaibhav Gupta, Kathleen Decker, Laura Davis, Gail Darling, Carolyn Compton, Natalie Coburn, Randy Boyes, Michael Pugliese, Alyson Mahar, Amy Hsu, Ge Shi, Andrew Kokavec, Edward Ho, Ryan Waterman, Edward Wang, Kiera Harnden, Richard Malthaner, Rahul Nayak, Mehdi Qiabi, Ge Shi, Richard Malthaner, Rahul Nayak, Mehdi Qiabi, Jacob A Alaichi, Yogita Patel, Forough Farrokhyar, Marko Simunovic, Wael C Hanna, Biniam Kidane, Stephen Gowing, Richard Liu, Sadeesh Srinathan, Larry Tan, Linda Chang Qu, Richard Malthaner, Jacob Alaichi, Peter Malik, Yogita Patel, Wael Hanna, Emily Mackay, Umeed Fahim, Ajmal Hafizi, Ahmad S Ashrafi, Jay Lee, Tyler McKechnie, Nalin Amin, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Kieran Purich, Courtney Streu, Clarence Wong, Dan Schiller, Matthew Castelo, Colin Sue-Chue-Lam, Lawrence Paszat, Adena Scheer, Bettina Hansen, Teruko Kishibe, Nancy Baxter, Antonio Caycedo-Marulanda, Emma Neary, Tarek Ibrahim, Chris Verschoor, Sunil Patel, Shaila Merchant, Sami Chadi, Luis Romagnolo, Antonio Caycedo-Marulanda, Chris Verschoor, Carl Brown, Ahmer Karimuddin, Manoj Raval, Terry Phang, Elena Vikis, George Melich, Sunil Patel, Kelly Brennan, Sunil Patel, Antonio Caycedo-Marulanda, Shaila Merchant, Christopher Booth, Weidong Kong, Chad McClintock, Clare Bankhead, Carl Heneghan, Kelly Brennan, Sunil Patel, Chad McClintock, Shaila Merchant, Antonio Caycedo-Marulanda, Christopher Booth, Clare Bankhead, Carl Heneghan, Kelly Brennan, Lisa Zhang, Jennifer Flemming, Maya Djerboua, Sulaiman Nanji, Antonio Caycedo-Marulanda, Shaila Merchant, Sunil Patel, Richard Garfinkle, Marie Demian, Sarah Sabboobeh, Jeongyoon Moon, Michael Hulme-Moir, A Sender Liberman, Stan Feinberg, Dana M Hayden, Sami A Chadi, Sebastian Demyttenaere, Louise Samuel, Nevart Hotakorzian, Laurence Quintin, Nancy Morin, Gabriela Ghitulescu, Julio Faria, Carol-Ann Vasilevsky, Marylise Boutros, Sahil Sharma, Tyler Mckechnie, Jigish Khamar, Simarpreet Ichhpuniani, Cagla Eskicioglu, Sydney Candy, Sunil Patel, Shaila Merchant, Antonio Caycedo-Marulanda, Clare Bankhead, Carl Heneghan, Tyler McKechnie, Shaylan Govind, Jay Lee, Yung Lee, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Justin Lu, Jigish Khamar, Yung Lee, Nalin Amin, Dennis Hong, Cagla Eskicioglu, Tyler McKechnie, Luisa Cardenas, Daniel Schep, Aristithes Doumouras, Dennis Hong, Raimond Wong, Oren Levine, Cagla Eskicioglu, Lawrence Lee, Carmen Mueller, Barry Stein, Patrick Charlebois, Sender Liberman, Gerald Fried, Liane Feldman, Stephan Robitaille, Anna Wang, Sender Liberman, Patrick Charlebois, Barry Stein, Julio F Fiore, Liane Feldman, Lawrence Lee, Stephan Robitaille, Anna Wang, Sender Liberman, Patrick Charlebois, Barry Stein, Julio F Fiore, Liane Feldman, Lawrence Lee, Hamid Sadri, Alan Barkun, Sydney Selznick, Jordan Levy, Ruxandra Bogdan, Jeffrey Hawel, Ahmad Elnahas, Nawar A Alkhamesi, Christopher M Schlachta, Vanessa Wiseman, Antonio Caycedo-Marulanda, Natasha Iaboni, David Hurlbut, Martin Kaufmann, Kevin Yi Mi Ren, Amoon Jamzad, Parvin Mousavi, Gabor Fichtinger, Christopher J B Nicol, John F Rudan, Vanessa Wiseman, Kelly Brennan, Antonio Caycedo-Marulanda, Shaila Merchant, Chad McClintock, Sunil V Patel, Vanessa Wiseman, Chad McClintock, Clare Bankhead, Shaila Merchant, Antonio Caycedo-Marulanda, Chris Booth, Carl Heneghan, Kelly Brennan, Lisa Zhang, Bright Huo, Alexandra Donaldson, Jennifer Flemming, Sulaiman Nanji, Antonio Caycedo-Marulanda, Shaila Merchant, Susan Brogly, Sunil Patel, Laura Baker, Tori Lenet, Lily Park, Sanjay Murthy, Reilly Musselman, Simarpreet Ichhpuniani, Tyler McKechnie, Jay Lee, Jeremy Biro, Yung Lee, Lily Park, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu, Garrett Johnson, Harminder Singh, Ramzi Helewa, Kristin Reynolds, Kathryn Sibley, Malcolm Doupe, Lisa Zhang, Kelly Brennan, Jennifer Flemming, Sulaiman Nanji, Shaila Merchant, Maya Djerboua, Antonio Caycedo-Marulanda, Sunil Patel, James Holden, Garrett Johnson, David Hochman, Ramzi Helewa, Jeongyoon Jenny Moon, Richard Garfinkle, Sophie Dell'Aniello, Phyllis Zelkowitz, Carol-Ann Vasilevsky, Paul Brassard, Marylise Boutros, Jeongyoon Jenny Moon, Amine Zoughlami, Wusiman Abibula, Alex Amar, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Paul Brassard, Marylise Boutros, Jeongyoon Jenny Moon, Théa Araji, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Jeongyoon Jenny Moon, Alexa Ehlebracht, Julio Faria, Gabriela Ghitulescu, Nancy Morin, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Tiffany Paradis, Stephan Robitaille, Mahalia Oliver, Patrick Charlebois, Barry Stein, Sender Liberman, Liane S Feldman, Lawrence Lee, Zubair Bayat, Erin Kennedy, Charles Victor, Anand Govindarajan, Sunil Patel, Lisa Zhang, Kelly Brennan, Maya Djerboua, Sulaiman Nanji, Shaila J Merchant, Antonio Caycedo-Marulanda, Jennifer Flemming, Michael Fares Maalouf, Stephan Robitaille, Ruxandra Penta, Makena Pook, Julio Flavio Fiore, Liane Feldman, Lawrence Lee, Alon Wachtel, Nathalie Wong-Chong, Daniel Marinescu, Sahir Bhatnagar, Nancy Morin, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Julio Faria, Marylise Boutros, Victoria Baronas, Arif Arif, Gale Ladua, Eric Bhang, Carl Brown, Fergal Donellan, Heather Stuart, Jonathan Loree, Vanessa Wiseman, Sunil Patel, Lisa Zhang, Peter Hugh MacDonald, Shaila Merchant, Kathleen Wattie Barnett, Antonio Caycedo-Marulanda, Jessica Lie, Carl Brown, Ahmer Karimuddin, Heather Stuart, Amandeep Ghuman, Terry Phang, Manoj Raval, Hyea Min Yoon, Roy Hajjar, Gabriela Fragoso, Manon Oliero, Annie Calvé, Hervé Vennin Rendos, Emmanuel Gonzalez, Nicholas J B Brereton, Thibault Cuisiniere, Claire Gerkins, Souad Djediai, Borhane Annabi, Khoudia Diop, Bertrand Routy, Patrick Laplante, Jean-François Cailhier, Nassima Taleb, Hefzi Alratrout, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric Debroux, Carole Richard, Manuela M Santos, Alexa Ehlebracht, Doulia Hamad, Hatim Alsulaim, Olivia Monton, Daniel Marinescu, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Natasha Caminsky, Daniel Marinescu, Mohammed Alqahtani, Allison Pang, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Marylise Boutros, Natasha Caminsky, Daniel Marinescu, Richard Garfinkle, Marylise Boutros, Richard Gilbert, Terry Zwiep, Joshua Greenberg, Tori Lenet, Reilly Musselman, Lara Williams, Isabelle Raiche, Daniel McIsaac, Kednapa Thavorn, Dean Fergusson, Husein Moloo, Geneviève Morin, Janyssa Charbonneau, Xavier Paré, Jonathan Frigault, François Letarte, Rebecca C Auer, Michael Ott, Paul Karanicolas, Muriel Brackstone, Shady Ashmalla, Joel Weaver, Vicky Tagalakis, Marylise Boutros, Peter Stotland, Antonio Caycedo-Marulanda, Husein Moloo, Shiva Jayaraman, Sunil Patel, Gregoire LeGal, Silvana Spadafora, Steven Maclellan, Daniel Trottier, Derek Jonker, Timothy Asmis, Ranjeeta Mallick, Timothy Ramsay, Marc Carrier, Terry Phang, Delaram Shojaei, Ali Motamedi, Anu Ghuman, Ahmer Karimuddin, Manoj Raval, Carl Brown, Delaram Shojaei, Jessica Hopkins, Haili Wang, Don Buie, Jessica Hopkins, Haili Wang, Don Buie, Yosef Levin, Nasra Al Busaidi, Fateme Rajabiyazdi, Marie Demian, Marylise Boutros, Armaghan Alam, Ameer Farooq, Carl Brown, Terry Phang, Amandeep Ghuman, Ahmer Karimuddin, Manoj Raval, Farhad Udwadia, Natasha Caminsky, Daniel Marinescu, Mohammed Alqahtani, Allison Pang, Carol-Ann Vasilevsky, Marylise Boutros, Sarah Mansouri, Sonia Cheng Oviedo, Nathalie McFadden, Philip Lagace, Richard Spence, Greg Hirsch, Katerina Neumann, Philip Lagace, Katerina Neumann, Richard Spence, Charbel El-Kefraoui, Garrett Johnson, Harminder Singh, Ramzi Helewa, Marguerite Mainprize, Ayse Yilbas, Fernando Spencer Netto, Joel Katz, Megan Melland-Smith, Bree Sharma, Usman Khan, Markus Selzner, Kevin Verhoeff, Valentin Mocanu, Jerry Dang, Hillary Wilson, Noah Switzer, Daniel Birch, Shahzeer Karmali, Kevin Verhoeff, Valentin Mocanu, Uzair Jogiat, Hayley Forbes, Noah Switzer, Daniel Birch, Shahzeer Karmali, Khadija Nasser, Kevin Verhoeff, Valentin Mocanu, Janice Kung, Kieran Purich, Noah Switzer, Daniel Birch, Shahzeer Karmali, Olivier Mailloux, Nicolas Tassé, André Tchernof, Mélanie Nadeau, Philip Dawe, Andrew Beckett, Laurent Biertho, Kieran Purich, Andrea Lin, Kevin Verhoeff, Valentin Mocanu, Janice Y Kung, Daniel W Birch, Shahzeer Karmali, Noah J Switzer, Marta Whyte, Melinda Fowler-Woods, Amanda Fowler-Woods, Geraldine Shingoose, Andrew Hatala, Felicia Daeninck, Ashley Vergis, Krista Hardy, Kathleen Clouston, Ting Li, Estifanos Debru, Mirza Shaharyar Ahmad, Warren Sun, Jerry Dang, Noah Switzer, Daniel Birch, Shahzeer Karmali, Christopher De Gara, Warren Sun, Jennifer Halasz, Jerry Dang, Noah Switzer, Aliyah Kanji, Daniel Birch, Renuca Modi, Shahzeer Karmali, Hilalion San Ahn, Jeffrey Gu, Amer Jarrar, Nicole Kolozsvari, Yung Lee, Yasith Samarasinghe, Lucy Chen, Akithma Hapugall, Arshia Javidan, Tyler McKechnie, Aristithes Doumouras, Dennis Hong, Eileen Roach, Simon Laplante, Shannon Stogryn, Azusa Maeda, Timothy Jackson, Allan Okrainec, Alexandra Chow, Daniel Birch, Shahzeer Karmali, Aliyah Kanji, Noah Switzer, Jessica Trac, Michael Balas, Denise Gee, Matthew Hutter, Ozanan Meireles, James Jung, Wenjing He, Ashley Vergis, Krista Hardy, Karim Ramji, Vanessa Boudreau, Dennis Hong, Mehran Anvari, Pouya Iranmanesh, Karen Barlow, Tyler Cookson, Rafik Bolis, Harsha Shanthanna, Jonah Shiroky, Ekaterina Kouzmina, Shaidah Deghan, Boris Zevin, Cypriana Koziak, Zacharie Cloutier, Tyler Cookson, Karen Barlow, Vanessa Boudreau, Mehran Anvari, Intekhab Hossain, Jane Brodie, Erin O'Brien, Katherine Tedman-Aucoin, Diana Lawlor, Raleen Murphy, Laurie Twells, David Pace, James Ellsmere, Bradley Evans, Valentin Mocanu, Terry Zhang, Edward Deehan, Dina Kao, Naomi Hotte, Daniel Birch, Shahzeer Karmali, Kalutota Samarasinghe, Jens Walter, Karen Madsen, Nader Hanna, Erin Williams, Weidong Kong, Adam Fundytus, Christopher Booth, Sunil Patel, Antonio Caycedo-Marulanda, Wiley Chung, Sulaiman Nanji, Shaila Merchant, Matthew Castelo, Bettina Hansen, Lawrence Paszat, Nancy Baxter, Adena Scheer, Makena Pook, Tahereh Najafi Ghezeljeh, Maxime Lapointe-Gagner, Philip Nguyen-Powanda, Hiba Elhaj, Fateme Rajabiyazdi, Lawrence Lee, Liane S Feldman, Julio Fiore, Jesse Zuckerman, Rinku Sutradhar, Barbara Haas, Matthew Guttman, Antoine Eskander, Natalie Coburn, Tyler Chesney, Bourke Tillman, Victoria Zuk, Alyson Mahar, Amy Hsu, Wing Chan, Julie Hallet, Woo Jin Choi, Keegan Guidolin, Filomena Servidio-Italiano, Fayez Quereshy, Gonzalo Sapisochin, Akie Watanabe, Eitan Prisman, Elliot Mitmaker, Ross Walker, Jonn Wu, Anne Nguyen, Sam Wiseman, Bianka Saravana-Bawan, Dennis Hong, Michael Gupta, Jesse Pasternak, David Cyr, Omar Vergara-Fernandez, Amanpreet Brar, James Conner, Richard Kirsch, Mantaj Brar, Erin Kennedy, Anand Govindarajan, Robert Gryfe, Helen MacRae, Zane Cohen, Robin McLeod, Carol Swallow, Muriel Brackstone, Farhad Ghasemi, Victoria Ivankovic, Megan Delisle, Dawn Stacey, Jad Abou-Khalil, Fady Balaa, Kimberly Bertens, Brittney Dingley, Guillaume Martel, Kristen McAlpine, Carolyn Nessim, Shaheer Tadros, Marc Carrier, Rebecca Auer, Ananya Gopika Nair, David Lim, Dhruvin Hirpara, Antoine Eskander, Natalie Coburn, Rinku Sutradhar, Wing Chan, Julie Hallet, Cecily Stockley, Felicia Pickard, Alexander Mathieson, Michael Hogan, Melanie Seal, Deanna Ng, Belkacem Acidi, Wendy Johnston, Dario Callegaro, Savtaj Brar, Rebecca Gladdy, Peter Chung, Charles Catton, Korosh Khalili, Charles Honore, Carol Swallow, Shelly Luu, Ning Fu, Karineh Kazazian, Karina Pacholczyk, Deanna Ng, Jossie Swett-Cosentino, Paul Savage, Yukiko Shibahara, Sangeetha Kalimuthu, Osvaldo Espin-Garcia, James Conner, Jonathan Yeung, Gail Darling, Carol Swallow, Léamarie Meloche-Dumas, Frédéric Mercier, Victoria Barabash, Calvin Law, Natalie Coburn, Simron Singh, Sten Myrehaug, Wing Chan, Julie Hallet, Michael A D'Elia, Rebecca C Auer, Ashley Eom, Narry Muhn, Barbara Heller, Peter Lovrics, Katelynn Tang, Shawn Khan, Deanna Ng, Daniel Koerber, Eisar Al-Sukhni, David Cyr, Karineh Kazazian, Carol Swallow, Erika Schmitz, Sameer Apte, Carolyn Nessim, Ko Ta Chen, Judy Ban, Leo Chen, Elaine McKevitt, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Urve Kuusk, Amy Bazzarelli, Jieun Newman-Bremang, Nicole Look Hong, Anna Gagliardi, Bryanna Nyhof, Kevin Verhoeff, Braulio Marfil-Garza, Gurpal Sandha, David Cooper, Khaled Dajani, David Bigam, Blaire Anderson, Tatsuya Kin, Anna Lam, Doug O'Gorman, Peter Senior, Camillo Ricordi, A M James Shapiro, Nic Jette, Michael Moser, Zuhaib Mir, Henry Lam, Jennifer Flemming, Diederick Jalink, Sulaiman Nanji, Sean Bennett, Christopher Griffiths, Betty Zhang, Kasia Tywonek, Brandon Meyers, Pablo Serrano, Luckshi Rajendran, Tori Lenet, Risa Shorr, Jad Abou-Khalil, Kimberly Bertens, Fady Balaa, Guillaume Martel, Jesse Zuckerman, Shiva Jayaraman, Alice Wei, Alyson Mahar, Yosuf Kaliwal, Guillaume Martel, Natalie Coburn, Julie Hallet, Woo Jin Choi, Phil Williams, Marco Claasen, Tommy Ivanics, Marina Englesakis, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin, Woo Jin Choi, Tommy Ivanics, Marco Claasen, Steven Gallinger, Bettina Hansen, Gonzalo Sapisochin, Richard Gilbert, Tori Lenet, Jad Abou-Khalil, Fady Balaa, Guillaume Martel, Alexandre Brind'Amour, Kimberly Bertens, Tori Lenet, Fady Balaa, Kimberly Bertens, Guillaume Martel, Jad Abou-Khalil, Nawal Amhis, Yves Collin, Marco Claasen, Tommy Ivanics, Christian Toso, Rene Adam, Jan Ijzermans, Gonzalo Sapisochin, Wojtek Polak, Sarah Mansouri, Maxime Léveillé, Christine Lawson, Yves Collin, Lee-Hwa Tai, Adriana Workewych, Brittany Greene, Shiva Jayaraman, Melanie Tsang, Alex Lee, Ahmed Al-Arnawoot, Luckshi Rajendran, Tyler Lamb, Anastasia Turner, Morgann Reid, Janelle Rekman, Richard Mimeault, Jad Abou-Khalil, Kimberly Bertens, Guillaume Martel, Fady Balaa, Evelyn Waugh, Chris Zhang, Madeline Lemke, Juan Glinka, Ken Leslie, Anton Skaro, Ephraim Tang, Alice Zhu, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Helia Nabavian, Lev Bubis, Shiva Jayaraman, Melanie E Tsang, Jorge Roldan, Olivia Ganescu, Tsafrir Vanounou, Jean-Sébastien Pelletier, Andrew Lagrotteria, Brittany Greene, Melanie Tsang, Shiva Jayaraman, Jorge Roldan, Olivia Ganescu, Jean-Sébastien Pelletier, Tsafrir Vanounou, Luckshi Rajendran, Woo Jin Choi, Hala Muaddi, Tommy Ivanics, Marco P A W Classen, Gonzalo Sapisochin
No abstract text is available yet for this article.
2022: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#15
JOURNAL ARTICLE
Sarah A Nadeau, Timothy G Vaughan, Christiane Beckmann, Ivan Topolsky, Chaoran Chen, Emma Hodcroft, Tobias Schär, Ina Nissen, Natascha Santacroce, Elodie Burcklen, Pedro Ferreira, Kim Philipp Jablonski, Susana Posada-Céspedes, Vincenzo Capece, Sophie Seidel, Noemi Santamaria de Souza, Julia M Martinez-Gomez, Phil Cheng, Philipp P Bosshard, Mitchell P Levesque, Verena Kufner, Stefan Schmutz, Maryam Zaheri, Michael Huber, Alexandra Trkola, Samuel Cordey, Florian Laubscher, Ana Rita Gonçalves, Sébastien Aeby, Trestan Pillonel, Damien Jacot, Claire Bertelli, Gilbert Greub, Karoline Leuzinger, Madlen Stange, Alfredo Mari, Tim Roloff, Helena Seth-Smith, Hans H Hirsch, Adrian Egli, Maurice Redondo, Olivier Kobel, Christoph Noppen, Louis du Plessis, Niko Beerenwinkel, Richard A Neher, Christian Beisel, Tanja Stadler
Genome sequences from evolving infectious pathogens allow quantification of case introductions and local transmission dynamics. We sequenced 11,357 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from Switzerland in 2020-the sixth largest effort globally. Using a representative subset of these data, we estimated viral introductions to Switzerland and their persistence over the course of 2020. We contrasted these estimates with simple null models representing the absence of certain public health measures...
January 25, 2023: Science Translational Medicine
#16
JOURNAL ARTICLE
Alexandra De Zutter, Luna Dillemans, Nele Berghmans, Sam Noppen, Helena Crijns, Paulien Verscheure, Janne Verhaegen, Erik Martens, Lotte Vanbrabant, Noëmie Pörtner, Dominique Schols, Paul Proost, Sofie Struyf
No abstract text is available yet for this article.
October 19, 2022: International Journal of Biological Macromolecules
#17
JOURNAL ARTICLE
Emiel Vanhulle, Thomas D'huys, Becky Provinciael, Joren Stroobants, Anita Camps, Sam Noppen, Dominique Schols, Els J M Van Damme, Piet Maes, Annelies Stevaert, Kurt Vermeire
Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity. In this work, we investigated the potential of UDA as a broad-spectrum antiviral agent against SARS-CoV-2. UDA potently blocks transduction of pseudotyped SARS-CoV-2 in A549.ACE2+ -TMPRSS2 cells, with IC50 values ranging from 0.32 to 1.22 µM. Furthermore, UDA prevents viral replication of the early Wuhan-Hu-1 strain in Vero E6 cells (IC50 = 225 nM), but also the replication of SARS-CoV-2 variants of concern, including Alpha, Beta and Gamma (IC50 ranging from 115 to 171 nM)...
2022: Frontiers in Cellular and Infection Microbiology
#18
REVIEW
Alexandra Kammen, Jonathon Cavaleri, Jordan Lam, Adam C Frank, Xenos Mason, Wooseong Choi, Marisa Penn, Kaevon Brasfield, Barbara Van Noppen, Stuart B Murray, Darrin Jason Lee
Early research into neural correlates of obsessive compulsive disorder (OCD) has focused on individual components, several network-based models have emerged from more recent data on dysfunction within brain networks, including the the lateral orbitofrontal cortex (lOFC)-ventromedial caudate, limbic, salience, and default mode networks. Moreover, the interplay between multiple brain networks has been increasingly recognized. As the understanding of the neural circuitry underlying the pathophysiology of OCD continues to evolve, so will too our ability to specifically target these networks using invasive and noninvasive methods...
2022: Frontiers in Neurology
#19
JOURNAL ARTICLE
Caroline P Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Tanja Gangnus, Bernard Noppen, Hanne Callewaert, Jean H M Feyen, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Leydi Carolina Velásquez Pereira, Sirima Kraisin, Ipek Guler, Matthias M Engelen, Anna Ockerman, Anke Van Herck, Robin Vos, Christophe Vandenbriele, Philippe Meersseman, Greet Hermans, Alexander Wilmer, Kimberly Martinod, Bjoern B Burckhardt, Marc Vanhove, Marc Jacquemin, Peter Verhamme, Johan Neyts, Thomas Vanassche
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein-kinin system. Its dysregulation may lead to increased vascular permeability and release of inflammatory chemokines. Interactions between the kallikrein-kinin and the coagulation system might further contribute to thromboembolic complications in COVID-19. METHODS: In this observational study, we measured plasma and tissue kallikrein hydrolytic activity, levels of kinin peptides, and myeloperoxidase (MPO)-DNA complexes as a biomarker for neutrophil extracellular traps (NETs), in bronchoalveolar lavage (BAL) fluid from patients with and without COVID-19...
August 5, 2022: EBioMedicine
#20
JOURNAL ARTICLE
Maya Imbrechts, Wim Maes, Louanne Ampofo, Nathalie Van den Berghe, Bas Calcoen, Dominique Van Looveren, Winnie Kerstens, Madina Rasulova, Thomas Vercruysse, Sam Noppen, Rana Abdelnabi, Caroline Foo, Kevin Hollevoet, Piet Maes, Xin Zhang, Dirk Jochmans, Karen Ven, Jeroen Lammertyn, Karen Vanhoorelbeke, Nico Callewaert, Paul De Munter, Dominique Schols, Hendrik Jan Thibaut, Johan Neyts, Paul Declerck, Nick Geukens
Treatment with neutralizing monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to COVID-19 management. Unfortunately, SARS-CoV-2 variants escape several of these recently approved mAbs, highlighting the need for additional discovery and development. In a convalescent COVID-19 patient, we identified six mAbs, classified in four epitope groups, that potently neutralized SARS-CoV-2 D614G, beta, gamma and delta infection in vitro , with three mAbs neutralizing omicron as well...
July 3, 2022: IScience
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