Kaden L Nystuen, Shannon M McNamee, Monica Akula, Kristina M Holton, Margaret M DeAngelis, Neena B Haider
Alzheimer's Disease (AD) is a complex neurodegenerative disease resulting in progressive loss of memory, language and motor abilities caused by cortical and hippocampal degeneration. This review captures the landscape of understanding of AD pathology, diagnostics, and current therapies. Two major mechanisms direct AD pathology: (1) accumulation of amyloid β (Aβ) plaque and (2) tau-derived neurofibrillary tangles (NFT). The most common variants in the Aβ pathway in APP , PSEN1, and PSEN2 are largely responsible for early-onset AD (EOAD), while MAPT , APOE , TREM2 and ABCA7 have a modifying effect on late-onset AD (LOAD)...
January 1, 2024: Bioengineering