keyword
https://read.qxmd.com/read/38483198/cardiac-surgery-associated-acute-kidney-injury-in-neonates-undergoing-the-norwood-operation-retrospective-analysis-of-the-multicenter-neonatal-and-pediatric-heart-and-renal-outcomes-network-dataset-2015-2018
#21
JOURNAL ARTICLE
Rebecca A Bertrandt, Katja Gist, Denise Hasson, Huaiyu Zang, Garrett Reichle, Catherine Krawczeski, David Winlaw, David Bailly, Stuart Goldstein, David Selewski, Jeffrey Alten
OBJECTIVES: Cardiac surgery-associated acute kidney injury (CS-AKI) is associated with adverse outcomes. Single-center studies suggest that the prevalence of CS-AKI is high after the Norwood procedure, or stage 1 palliation (S1P), but multicenter data are lacking. DESIGN: A secondary analysis of the Neonatal and Pediatric Heart and Renal Outcomes Network (NEPHRON) multicenter cohort who underwent S1P. Using neonatal modification of Kidney Disease Improving Global Outcomes (KDIGO) criteria, perioperative associations between CS-AKI with morbidity and mortality were examined...
March 14, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38483146/-porphyromonas-gingivalis-induced-hematogenous-disseminated-severe-pneumonia-a-case-report
#22
JOURNAL ARTICLE
Zhou Yuanjun, Cai Yan, Zhang Qingyan, Xiong Feng
Porphyromonas gingivalis , a gram-negative oral anaerobe among more than more than 500 bacterial species that colonizing the oral cavity, is involved in the pathogenesis and prototypic polybacterial consortium of periodontitis. It is mainly found in oral infections and rarely present in other organ diseases. Here, we describe a 43-year-old man with underlying diabetes who developed hematogenous disseminated severe pneumonia after P. gingivalis had invaded the blood. Next-generation sequencing of early alveolar lavage fluid and blood samples confirmed the diagnosis...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38481419/veno-venous-extracorporeal-membrane-oxygenation-in-severe-acute-respiratory-failure
#23
REVIEW
J Offer, C Sampson, M Charlton
No abstract text is available yet for this article.
April 2024: BJA Education
https://read.qxmd.com/read/38479299/health-related-quality-of-life-physical-function-and-cognitive-performance-in-mechanically-ventilated-covid-19-patients-a-long-term-follow-up-study
#24
JOURNAL ARTICLE
Luca Carenzo, Leonardo Zini, Cesare Mercalli, Niccolò Stomeo, Angelo Milani, Katia Amato, Roberto Gatti, Elena Costantini, Romina Aceto, Alessandro Protti, Maurizio Cecconi
BACKGROUND: Survivors of severe COVID-19 related respiratory failure may experience durable functional impairments. We aimed at investigating health-related quality of life (HR-QoL), physical functioning, fatigue, and cognitive outcomes in COVID-19 patients who received invasive mechanical ventilation (IMV). METHODS: Case-series, prospective, observational cohort study at 18 months from hospital discharge. Patients referring to the Intensive Care Unit (ICU) of Humanitas Research Hospital (Milan, Italy) were recruited if they needed IMV due to COVID-19 related respiratory failure...
March 12, 2024: Journal of Critical Care
https://read.qxmd.com/read/38478363/provider-experience-with-the-use-of-ketamine-for-refractory-status-epilepticus
#25
JOURNAL ARTICLE
Gabriela Tantillo, Nicole Davis, Justin Granstein, Ji Yeoun Yoo, Parul Agarwal, Kaitlin Reilly, Alexandra Reynolds, Gina Kayal, John Liang, Nathalie Jetté
OBJECTIVE: Refractory status epilepticus (RSE) treated with anesthetic agents can be associated with complications including respiratory depression and hypotension. Ketamine is an emerging RSE treatment, but optimal dosing and timing are unknown. We studied provider attitudes and practices regarding the use of ketamine for RSE. METHODS: A literature review informed the creation of the survey, developed by professionals in epilepsy, pharmacy, and neurocritical care...
March 2024: Clinical Neuropharmacology
https://read.qxmd.com/read/38477798/long-term-outcomes-for-epidemic-viral-pneumonia-survivors-after-discharge-from-the-intensive-care-unit-a-systematic-review
#26
JOURNAL ARTICLE
Larrie Rabelo Laporte, Alexandre von Flach Garcia Chavez, Otavio Tavares Ranzani, Juliana Caldas, Rogerio da Hora Passos, João Gabriel Rosa Ramos
OBJECTIVE: To review the long-term outcomes (functional status and psychological sequelae) of survivors of critical illnesses due to epidemic viral pneumonia before the COVID-19 pandemic and to establish a benchmark for comparison of the COVID-19 long-term outcomes. METHODS: This systematic review of clinical studies reported the long-term outcomes in adults admitted to intensive care units who were diagnosed with viral epidemic pneumonia. An electronic search was performed using databases: MEDLINE®, Web of Science™, LILACS/IBECS, and EMBASE...
February 2024: Einstein
https://read.qxmd.com/read/38477675/low-dose-morphine-does-not-cause-sleepiness-in-copd-a-secondary-analysis-of-a-randomized-trial
#27
JOURNAL ARTICLE
Thomas J Altree, Barbara Toson, Kelly A Loffler, Magnus Ekström, David C Currow, Danny J Eckert
RATIONALE: Regular, low-dose, sustained-release morphine is frequently prescribed for persistent breathlessness in chronic obstructive pulmonary disease (COPD). However, effects on daytime sleepiness, perceived sleep quality and daytime function have not been rigorously investigated. OBJECTIVES: Determine the effects of regular, low-dose, sustained-release morphine on sleep parameters in COPD. METHODS: Pre-specified secondary analyses of validated sleep questionnaire data from a randomized trial of daily, low-dose, sustained -release morphine versus placebo over four weeks commencing at 8mg or 16mg/day with blinded up-titration over two weeks to a maximum of 32mg/day...
March 13, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38477657/tackling-brain-and-muscle-dysfunction-in-acute-respiratory-distress-syndrome-survivors-national-heart-lung-and-blood-institute-workshop-report
#28
JOURNAL ARTICLE
Jessica A Palakshappa, Jane A E Batt, Sue C Bodine, Bronwen A Connolly, Jason Doles, Jason R Falvey, Lauren E Ferrante, D Clark Files, Michael O Harhay, Kirsten Harrell, Joseph A Hippensteel, Theodore J Iwashyna, James C Jackson, Meghan B Lane-Fall, Michelle Monje, Marc Moss, Dale M Needham, Matthew W Semler, Shouri Lahiri, Lars Larsson, Carla M Sevin, Tarek Sharshar, Benjamin Singer, Troy Stevens, Stephanie P Taylor, Christian R Gomez, Guofei Zhou, Timothy D Girard, Catherine L Hough
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproven. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation...
March 13, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38477010/retrospective-analysis-of-clinical-characteristics-and-outcomes-of-pregnant-women-with-sars-cov-2-infections-admitted-to-intensive-care-units-in-india-preg-cov-a-multicenter-study
#29
JOURNAL ARTICLE
Sharmili Sinha, Gunchan Paul, Bhagyesh A Shah, Tejas Karmata, Naveen Paliwal, Jayesh Dobariya, Behera Srikant, Aarti Mona, Vipul P Thakkar, Gunadhar Padhi, Pooja Bihani, Saurabh Karmakar, Jay Prakash, Mayurdhwaja Rath, Anand Mishra, Vinay Singhal, Alpesh Ruparelia, Alisha Chaudhury, Alaukik Goyal
AIM: The aim was to examine the outcomes of pregnant women admitted to intensive care unit with coronavirus disease-2019 (COVID-19) infection during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in India. The primary outcome of the study was maternal mortality at day 30. The secondary outcomes were the intensive care unit (ICU) and hospital length of stay, fetal mortality and preterm delivery. MATERIALS AND METHODS: This was a retrospective multicentric cohort study...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38477006/comparison-of-oxygen-delivery-devices-in-postoperative-patients-with-hypoxemia-an-open-labeled-randomized-controlled-study
#30
JOURNAL ARTICLE
Susri Mishra, Nikhil Kothari, Ankur Sharma, Shilpa Goyal, Darshna Rathod, Tanvi Meshram, Pradeep Bhatia
BACKGROUND: Acute hypoxemic respiratory failure is among the more commonly occurring complications in postoperative patients. Supplemental oxygen and addressing the primary etiology form the basis of its treatment. MATERIALS AND METHODS: We conducted an open-labeled randomized control trial with 90 adult patients and compared three oxygen delivery vehicles (ODV), i.e., noninvasive ventilation (NIV), high-flow nasal cannula (HFNC), and venturi mask (VM) in postoperative hypoxemic patients...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38477001/comparison-of-the-recent-expres-score-weansnow-score-and-the-parsimonious-hacor-score-as-the-best-predictor-of-weaning-an-externally-validated-prospective-observational-study
#31
JOURNAL ARTICLE
Gautham Nayak, Souvik Chaudhuri, Sunil Ravindranath, Pratibha Todur
BACKGROUND: Since weaning failure is multifactorial, comprehensive weaning scores encompassing not only the respiratory component but also nonrespiratory aspects are quintessential for successful weaning prediction. MATERIALS AND METHODS: This was a single-center prospective observational study on 128 intensive care unit (ICU) patients undergoing spontaneous breathing trials (SBT). The extubation prediction score (ExPreS), heart rate, acidosis, consciousness, oxygenation, respiratory rate (HACOR), and weaning parameters, endotracheal tube size, arterial blood gas analysis, nutrition, secretions, neuromuscular affecting agents, obstructive airway problems and wakefulness (WEANSNOW) scores were compared for their diagnostic accuracy for successful weaning prediction...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38476999/a-game-changer-for-ards-unraveling-the-potential-of-the-sf-ratio
#32
EDITORIAL
Rajavardhan Rangappa
Rangappa R. A Game Changer for ARDS? Unraveling the Potential of the SF Ratio. Indian J Crit Care Med 2024;28(3):191-192.
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38476998/a-prospective-observational-study-comparing-oxygen-saturation-fraction-of-inspired-oxygen-ratio-with-partial-pressure-of-oxygen-in-arterial-blood-fraction-of-inspired-oxygen-ratio-among-critically-ill-patients-requiring-different-modes-of-oxygen-supplementation
#33
JOURNAL ARTICLE
T Rakesh Alur, Shivakumar S Iyer, Jignesh N Shah, Sampada Kulkarni, Prashant Jedge, Vishwanath Patil
BACKGROUND: Intensive care unit (ICU) patients face a significant rise in mortality rates due to acute hypoxemic respiratory failure (AHRF). The diagnosis of AHRF is based on the PF ratio, but it has limitations in resource-constrained settings. Instead, the Kigali modification suggests using the oxygen saturation/fraction of inspired oxygen (SF) ratio. This study aims to correlate SF ratio and arterial oxygen pressure (PF) ratio in critically ill adults with hypoxemic respiratory failure, who required O2 therapy through different modes of oxygen supplementation...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38476879/multimodal-acute-pain-management-in-the-parturient-with-opioid-use-disorder-a-review
#34
REVIEW
Victor Koltenyuk, Ismat Mrad, Ian Choe, Mohamad Ibrahim Ayoub, Sangeeta Kumaraswami, Jeff L Xu
The opioid epidemic in the United States has led to an increasing number of pregnant patients with opioid use disorder (OUD) presenting to obstetric units. Caring for this complex patient population requires an interdisciplinary approach involving obstetricians, anesthesiologists, addiction medicine physicians, psychiatrists, and social workers. The management of acute pain in the parturient with OUD can be challenging due to several factors, including respiratory depression, opioid tolerance, and opioid-induced hyperalgesia...
2024: Journal of Pain Research
https://read.qxmd.com/read/38476066/clinical-characteristics-and-outcomes-of-obstetric-patients-transferred-directly-to-intensive-care-units
#35
JOURNAL ARTICLE
Saad Pirzada, Kimberly Boswell, Jerry Yang, Samantha Asuncion, Fernando Albelo, Amanda Tuchler, Lauren Becker, Allison Lankford, Emad Elsamadicy, Quincy K Tran
BACKGROUND: Medical complications in peripartum patients are uncommon. Often, these patients are transferred to tertiary care centers, but their conditions and outcomes are not well understood. Our study examined peripartum patients transferred to an intensive care unit (ICU) at an academic quaternary center. METHODS: We reviewed charts of adult, non-trauma, interhospital transfer (IHT) peripartum patients sent to an academic quaternary ICU between January 2017 and December 2021...
February 2024: Acute and critical care
https://read.qxmd.com/read/38476061/liberation-from-mechanical-ventilation-in-critically-ill-patients-korean-society-of-critical-care-medicine-clinical-practice-guidelines
#36
Tae Sun Ha, Dong Kyu Oh, Hak-Jae Lee, Youjin Chang, In Seok Jeong, Yun Su Sim, Suk-Kyung Hong, Sunghoon Park, Gee Young Suh, So Young Park
BACKGROUND: Successful liberation from mechanical ventilation is one of the most crucial processes in critical care because it is the first step by which a respiratory failure patient begins to transition out of the intensive care unit and return to their own life. Therefore, when devising appropriate strategies for removing mechanical ventilation, it is essential to consider not only the individual experiences of healthcare professionals, but also scientific and systematic approaches...
February 2024: Acute and critical care
https://read.qxmd.com/read/38475786/transitions-of-blood-immune-endotypes-and-improved-outcome-by-anakinra-in-covid-19-pneumonia-an-analysis-of-the-save-more-randomized-controlled-trial
#37
RANDOMIZED CONTROLLED TRIAL
Evdoxia Kyriazopoulou, Yehudit Hasin-Brumshtein, Uros Midic, Garyfallia Poulakou, Haralampos Milionis, Simeon Metallidis, Myrto Astriti, Archontoula Fragkou, Aggeliki Rapti, Eleonora Taddei, Ioannis Kalomenidis, Georgios Chrysos, Andrea Angheben, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vasiliki Tzavara, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios Kotsis, Dionysios G Tsoukalas, Carlo Selmi, Alexandra Konstantinou, Michael Samarkos, Michael Doumas, Aikaterini Masgala, Konstantinos Pagkratis, Aikaterini Argyraki, Karolina Akinosoglou, Styliani Symbardi, Mihai G Netea, Periklis Panagopoulos, George N Dalekos, Oliver Liesenfeld, Timothy E Sweeney, Purvesh Khatri, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human interleukin 1 receptor antagonist) in participants in the SAVE-MORE trial. METHODS: Adult patients hospitalized with radiological findings of PCR-confirmed severe pneumonia caused by SARS-CoV-2 and plasma-soluble urokinase plasminogen activator receptor levels of ≥ 6 ng/ml in the SAVE-MORE trial (NCT04680949) were characterized at baseline and days 4 and 7 of treatment using a previously defined 33-messenger RNA classifier to assign an immunological endotype in blood...
March 12, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38471985/application-of-a-multiplex-molecular-pneumonia-panel-and-real-world-impact-on-antimicrobial-stewardship-among-patients-with-hospital-acquired-and-ventilator-associated-pneumonia-in-intensive-care-units
#38
JOURNAL ARTICLE
Chieh-Lung Chen, How-Yang Tseng, Wei-Cheng Chen, Shinn-Jye Liang, Chih-Yen Tu, Yu-Chao Lin, Po-Ren Hsueh
BACKGROUND: The optimal timing for applying the BioFire FilmArray Pneumonia Panel (FAPP) in intensive care unit (ICU) patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP) remains undefined, and there are limited data on its impact on antimicrobial stewardship. METHODS: This retrospective study was conducted at a referral hospital in Taiwan from November 2019 to October 2022. Adult ICU patients with HAP/VAP who underwent FAPP testing were enrolled...
March 6, 2024: Journal of Microbiology Immunology and Infection
https://read.qxmd.com/read/38471954/-human-accumulation-and-toxic-effects-of-microplastics%C3%AF-a-critical-review
#39
REVIEW
Ya-Bo Bao, Cheng-Chen Wang, Wu-Guang Peng, Dai-Qian Nong, Ping Xiang
The effect of microplastics on the ecological environment and human health has become a topical issue, and research on the risks and harmful effects of MPs on human health in particular has attracted widespread attention. Due to the characteristics of small size, low degradability, and easy migration, MPs continuously migrate from the environment to the human body, and their main exposure pathways are oral ingestion, inhalation, and dermal contact, with the main exposure media being food, drinking water, dust, personal care products, etc...
February 8, 2024: Huan Jing Ke Xue= Huanjing Kexue
https://read.qxmd.com/read/38471792/patient-stratification-using-plasma-cytokines-and-their-regulators-in-sepsis-relationship-to-outcomes-treatment-effect-and-leucocyte-transcriptomic-subphenotypes
#40
JOURNAL ARTICLE
David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight
RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar subphenotypes exist in sepsis populations where leucocyte transcriptomic-defined subphenotypes have been reported...
March 12, 2024: Thorax
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