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https://www.readbyqxmd.com/read/29045971/-technical-improvement-in-retroperitoneal-laparoscopic-living-donor-nephrectomy-report-of-193-cases
#1
L Zhao, L L Ma, H X Zhang, X F Hou, L Liu, Y Fu, Y G Kou, Y M Song
OBJECTIVE: To summarize our experience of retroperitoneal laparoscopic living donor nephrectomy, our continuous technical improvements and refinement of this skill and standardization of each procedure of this operation. METHODS: Having approved by hospital ethical committee and local government administration, a total of 193 living donors underwent retroperitoneal laparoscopic living donor nephrectomy from Dec.2003 to Feb. 2016 in our department. Under general anaesthesia, the operation was performed through 3 lumbar ports...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29043816/axial-confocal-tomography-of-capillary-contained-colloidal-structures
#2
Shir R Liber, Ganit Indech, Ernest Benjamin Van der Wee, Alexander V Butenko, Thomas E Kodger, Peter James Lu, Andrew B Schofield, David A Weitz, Alfons van Blaaderen, Eli Sloutskin
Confocal microscopy is widely used for three-dimensional (3D) sample reconstructions. Arguably, the most significant challenge in such reconstructions is posed by the resolution along the optical axis being significantly lower than in the lateral directions. In addition, the imaging rate is lower along the optical axis in most confocal architectures, prohibiting reliable 3D reconstruction of dynamic samples. Here we demonstrate a very simple, cheap, and generic method of multiangle microscopy, allowing high resolution high-rate confocal slice collection to be carried out with capillary-contained colloidal samples, in a wide range of slice orientations...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29042497/a-single-dual-function-enzyme-controls-the-production-of-inflammatory-nod-agonist-peptidoglycan-fragments-by-neisseria-gonorrhoeae
#3
Jonathan D Lenz, Kathleen T Hackett, Joseph P Dillard
Neisseria gonorrhoeae gonococcus (GC) is a Gram-negative betaproteobacterium and causative agent of the sexually transmitted infection gonorrhea. During growth, GC releases lipooligosaccharide (LOS) and peptidoglycan (PG) fragments, which contribute significantly to the inflammatory damage observed during human infection. In ascending infection of human Fallopian tubes, inflammation leads to increased risk of ectopic pregnancy, pelvic inflammatory disease, and sterility. Of the PG fragments released by GC, most are disaccharide peptide monomers, and of those, 80% have tripeptide stems despite the observation that tetrapeptide stems make up 80% of the assembled cell wall...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29040603/mitosis-specific-acetylation-tunes-ran-effector-binding-for-chromosome-segregation
#4
Xiaoling Bao, Heng Liu, Xing Liu, Ke Ruan, Yonghui Zhang, Zhiyong Zhang, Qi Hu, Ying Liu, Saima Akram, Jiahai Zhang, Qingguo Gong, Wenwen Wang, Xiao Yuan, Jian Li, Lingli Zhao, Zhen Dou, Ruijun Tian, Xuebiao Yao, Jihui Wu, Yunyu Shi
Stable transmission of genetic information during cell division requires faithful mitotic spindle assembly and chromosome segregation. The Ran GTPase plays a key role in mitotic spindle assembly. However, how the generation of a chemical gradient of Ran-GTP at the spindle is coupled to mitotic post-translational modifications has never been characterized. Here, we solved the complex structure of Ran with the nucleotide release factor Mog1 and delineated a novel mitosis-specific acetylation-regulated Ran-Mog1 interaction during chromosome segregation...
October 6, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29037465/influence-of-exposure-time-on-the-release-of-bacteria-from-a-biofilm-on-ti6al4v-discs-using-sonication-an-in-vitro-model
#5
Laura Prieto-Borja, Ana Conde, María A Arenas, Juan J de Damborenea, Jaime Esteban
Implant sonication is considered a useful method for the diagnosis of implant-related infections. We designed an in vitro study using Ti6Al4V discs and 5 different bacteria to determine the optimal sonication time for recovery of most bacteria tested to enable use of sonication in clinical practice for microbiological diagnosis of implant-related infections. We carried out a specific protocol for the adherence and subsequent biofilm formation on the materials used. The discs were then sonicated and the retrieved bacteria were quantified...
August 25, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29035969/effects-of-medical-food-leucine-content-in-the-management-of-methylmalonic-and-propionic-acidemias
#6
Jennifer G Myles, Irini Manoli, Charles P Venditti
PURPOSE OF REVIEW: The current review highlights the varied effects of medical foods high in leucine (Leu) and devoid of valine (Val) and isoleucine (Ile) in the management of methylmalonic acidemia (MMA) and propionic acidemia and cobalamin C (cblC) deficiency, aiming to advance dietary practices. RECENT FINDINGS: Leu is a key metabolic regulator with a multitude of effects on different organ systems. Recent observational studies have demonstrated that these effects can have unintended consequences in patients with MMA as a result of liberal use of medical foods...
October 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29034720/investigating-the-neuroanatomical-substrate-of-pathological-laughing-and-crying-in-amyotrophic-lateral-sclerosis-with-multimodal-neuroimaging-techniques
#7
Foteini Christidi, Efstratios Karavasilis, Panagiotis Ferentinos, Sophia Xirou, Georgios Velonakis, Michalis Rentzos, Vasiliki Zouvelou, Ioannis Zalonis, Efstathios Efstathopoulos, Nikolaos Kelekis, Ioannis Evdokimidis
OBJECTIVE: Pathological laughing and crying (PLC) is common in several neurological and psychiatric diseases and is associated with a distributed network involving the frontal cortex, the brainstem and cortico-pontine-cerebellar circuits. By applying multimodal neuroimaging approach, we examined the neuroanatomical substrate of PLC in a sample of patients with amyotrophic lateral sclerosis (ALS). METHODS: We studied 56 non-demented ALS patients and 25 healthy controls (HC)...
October 15, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29033215/treating-resistant-pseudomonas-aeruginosa-lung-disease-in-young-children-with-cystic-fibrosis
#8
REVIEW
Sandy Z P Lim, Dominic A Fitzgerald
Pseudomonas aeruginosa is a common bacterial pathogen in the evolution of bronchiectasis in cystic fibrosis. The appearance of resistant strains of pseudomonas is increasing with the earlier and more liberal use of a range of anti-pseudomonal antibiotics for the treatment of bacterial chest infections. The rationale for treatment and potential benefits of aggressive treatment of resistant strains of Pseudomonas aeruginosa from early in life are discussed.
September 1, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29032677/ultrasensitive-ratiometric-homogeneous-electrochemical-microrna-biosensing-via-target-triggered-ru-iii-release-and-redox-recycling
#9
Panpan Gai, Chengcheng Gu, Haiyin Li, Xinzhi Sun, Feng Li
A new label-free and enzyme-free ratiometric homogeneous electrochemical microRNA biosensing platform was constructed via target-triggered Ru(III) release and redox recycling. To design the effective ratiometric dual-signal strategy, [Ru(NH3)6](3+) (Ru(III)) as one of electroactive probe was ingeniously entrapped in the pores of positively charged mesoporous silica nanoparticle (PMSN), as well as another electroactive probe [Fe(CN)6](3-) (Fe(III)) was selected to facilitate Ru(III) redox reclycling due to their distinctly separated reduction potential and different redox properties...
October 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29031210/effect-of-photoactivated-riboflavin-on-the-biodegradation-resistance-of-root-dentin-collagen
#10
Balasankar Meera Priyadarshini, Thong Beng Lu, Amr S Fawzy
This study was conducted to evaluate the effect of UVA-activated 1% riboflavin solution on structural integrity; mechanical properties and stability; and collagenase-mediated collagen solubilisation resistance of demineralized root dentin collagen matrix. Root dentin specimens demineralized with 17% EDTA for 7days were treated with 1% RF for 1min followed by UVA photo-activation at intensity 7mW/cm(2) for 1min. Control specimens were completely devoid of riboflavin and/or UVA treatments. Specimens were challenged with bacterial collagenase type-I solution for different time-periods at 37°C...
October 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29030915/political-transition-and-emergent-forest-conservation-issues-in-myanmar
#11
REVIEW
Graham W Prescott, William J Sutherland, Daniel Aguirre, Matthew Baird, Vicky Bowman, Jake Brunner, Grant M Connette, Martin Cosier, David Dapice, Jose Don T De Alban, Alex Diment, Julia Fogerite, Jefferson Fox, Win Hlaing, Saw Htun, Jack Hurd, Katherine LaJeunesse Connette, Felicia Lasmana, Cheng Ling Lim, Antony Lynam, Aye Chan Maung, Benjamin McCarron, John F McCarthy, William J McShea, Frank Momberg, Myat Su Mon, Than Myint, Robert Oberndorf, Thaung Naing Oo, Jacob Phelps, Madhu Rao, Dietrich Schmidt-Vogt, Hugh Speechly, Oliver Springate-Baginski, Robert Steinmetz, Kirk Talbott, Maung Maung Than, Tint Lwin Thaung, Salai Cung Lian Thawng, Kyaw Min Thein, Shwe Thein, Robert Tizard, Tony Whitten, Guy Williams, Trevor Wilson, Kevin Woods, Alan D Ziegler, Michal Zrust, Edward L Webb
Political and economic transitions have had substantial impacts on forest conservation. Where transitions are underway or anticipated, historical precedent and methods for systematically assessing future trends should be used to anticipate likely threats to forest conservation and design appropriate and prescient policy measures to counteract them. Myanmar is transitioning from an authoritarian, centralized state with a highly regulated economy to a more decentralized and economically liberal democracy and is working to end a long-running civil war...
October 14, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29027669/changes-in-public-attitudes-and-perceptions-about-homelessness-between-1990-and-2016
#12
Jack Tsai, Crystal Yun See Lee, Thomas Byrne, Robert H Pietrzak, Steven M Southwick
Public attitudes on homelessness can and has influenced policies and services for homeless populations. This study surveyed national public attitudes about homelessness in the 21st century and examined changes in attitudes in the past two decades. An online survey of public attitudes about homelessness was conducted with 541 U.S. adults across 47 states in November 2016 using Amazon Mechanical Turk. Survey results were compared to two public surveys conducted in 1990. Compared to previous surveys, the current sample endorsed more compassion, government support, and liberal attitudes about homelessness...
October 13, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29027132/submicrometer-emitter-esi-tips-for-native-mass-spectrometry-of-membrane-proteins-in-ionic-and-nonionic-detergents
#13
Anna C Susa, Jennifer L Lippens, Zijie Xia, Joseph A Loo, Iain D G Campuzano, Evan R Williams
Native mass spectrometry (native-MS) of membrane proteins typically requires a detergent screening protocol, protein solubilization in the preferred detergent, followed by protein liberation from the micelle by collisional activation. Here, submicrometer nano-ESI emitter tips are used for native-MS of membrane proteins solubilized in both nonionic and ionic detergent solutions. With the submicrometer nano-ESI emitter tips, resolved charge-state distributions of membrane protein ions are obtained from a 150 mM NaCl, 25 mM Tris-HCl with 1...
October 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29027043/clinical-psychological-features-and-quality-of-life-of-fibromyalgia-patients-a-cross-sectional-study-of-chinese-sample
#14
Ying Zhang, Dongfeng Liang, Ronghuan Jiang, Xiaojian Ji, Yiwen Wang, Jian Zhu, Jianglin Zhang, Feng Huang
This study aimed to determine the clinical, psychological features, and quality of life in Chinese fibromyalgia (FM) patients who fulfilled the American College of Rheumatology (ACR) 2010 FM classification criteria at initial diagnosis. A cross-sectional study was carried out in the Chinese People's Liberation Army (PLA) General Hospital. A hundred and seven Chinese FM patients (86 females, 21 males) were included. Eighty-six patients completed the questionnaires. Descriptive, differences, and correlation analyses were performed...
October 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29024928/zinc-inhibits-collagenolysis-by-cathepsin-k-and-matrix-metalloproteinases-in-demineralized-dentin-matrix
#15
Pinar Altinci, Roda Seseogullari-Dirihan, Gulsen Can, David Pashley, Arzu Tezvergil-Mutluay
The enzymatic degradation of dentin organic matrix occurs via both the action of matrix metalloproteinases (MMPs) and cysteine cathepsins (CCs). Zinc can prevent collagen hydrolysis by MMPs. However, its effect on the activity of dentin-bound CCs is not known. The aim of this study was to investigate the effect of zinc on matrix-bound cathepsin K and MMP activity in dentin. Completely demineralized dentin beams were divided into test groups (n = 9) and incubated at 37°C in an incubation media (1 mL) containing ZnCl2 of 0...
October 13, 2017: Caries Research
https://www.readbyqxmd.com/read/29024643/gbps-inhibit-motility-of-shigella-flexneri-but-are-targeted-for-degradation-by-the-bacterial-ubiquitin-ligase-ipah9-8
#16
Michal P Wandel, Claudio Pathe, Emma I Werner, Cara J Ellison, Keith B Boyle, Alexander von der Malsburg, John Rohde, Felix Randow
Interferon exposure boosts cell-autonomous immunity for more efficient pathogen control. But how interferon-enhanced immunity protects the cytosol against bacteria and how professionally cytosol-dwelling bacteria avoid clearance are insufficiently understood. Here we demonstrate that the interferon-induced GTPase family of guanylate-binding proteins (GBPs) coats Shigella flexneri in a hierarchical manner reliant on GBP1. GBPs inhibit actin-dependent motility and cell-to-cell spread of bacteria but are antagonized by IpaH9...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29021272/combined-salt-and-caloric-restrictions-potential-adverse-outcomes
#17
Tsuyoshi Homma, Mika Homma, Yuefei Huang, Korapat Mayurasakorn, Nurul Mahamad Rodi, Anis Amalina Abdul Hamid, Shelley Hurwitz, Tham Yao, Gail K Adler, Luminita H Pojoga, Gordon H Williams, Jose R Romero
BACKGROUND: We hypothesized that caloric restriction (CR) and salt restriction (ResS) would have similar effects on reducing cardiovascular risk markers and that combining CR and ResS would be synergistic in modulating these markers. METHODS AND RESULTS: To test our hypothesis, rats were randomized into 2 groups: ad libitum liberal salt diet (ad libitum/high-sodium, 1.6% sodium) or ResS diet (ad libitum/ResS, 0.03% sodium). CR was initiated in half of the rats in each group by reducing caloric intake to 60% while maintaining sodium intake constant (CR/high-sodium, 2...
October 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29020375/food-insecurity-in-denmark-socio-demographic-determinants-and-associations-with-eating-and-health-related-variables
#18
Thomas B Lund, Lotte Holm, Inge Tetens, Sinne Smed, Annemette L Nielsen
Background: Food insecurity and its consequences have not received much attention in the Nordic, social-democratic welfare states. This study reports the prevalence of low and very low food security in Denmark, identifies its socio-demographic determinants and examines its associations with eating-related and health-related outcomes. Methods: A cross-sectional survey with a mixed-mode response format (telephone interviewing or Internet). A disproportional stratified random sampling design was employed ( N = 1877)...
September 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29019798/the-return-to-literature-making-doctors-matter-in-the-new-era-of-medicine
#19
Daniel Marchalik
The rapid explosion of medical knowledge of the 19th and 20th centuries required a transformation in medical education, which, to that point, had been marked by low educational standards. To combat the lack of regulation, the 1910 Flexner Report recommended sweeping reforms. By 1930, students hoping to enroll in a medical school would need to complete courses in chemistry, physics, and biology, leaving little room for the liberal arts.Medicine is once again changing. The impact of artificial intelligence is being felt across all medical fields, and the nature of physicians' jobs in the new landscape of intelligent machines will inevitably also have to change...
October 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29019300/the-politics-of-cognition-liberalism-and-the-evolutionary-origins-of-victorian-education
#20
Matthew Daniel Eddy
In recent years the historical relationship between scientific experts and the state has received increasing scrutiny. Such experts played important roles in the creation and regulation of environmental organizations and functioned as agents dispatched by politicians or bureaucrats to assess health-related problems and concerns raised by the public or the judiciary. But when it came to making public policy, scientists played another role that has received less attention. In addition to acting as advisers and assessors, some scientists were democratically elected members of local and national legislatures...
October 11, 2017: British Journal for the History of Science
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