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https://www.readbyqxmd.com/read/28735230/granulometry-microbial-composition-and-biological-activity-of-dusts-collected-in-french-dairy-farms
#1
Hugo Pfister, Claudie Morzadec, Pierre Le Cann, Laurent Madec, Valérie Lecureur, Martine Chouvet, Stéphane Jouneau, Laurent Vernhet
BACKGROUND: Dairy working increases the prevalence of lower airway respiratory diseases, especially COPD and asthma. Epidemiological studies have reported that chronic inhalation of organic dusts released during specific daily tasks could represent a major risk factor for development of these pathologies in dairy workers. Knowledge on size, nature and biological activity of such organic dusts remain however limited. OBJECTIVE: To compare size distribution, microbial composition and cellular effects of dusts liberated by the spreading of straw bedding in five French dairy farms located in Brittany...
July 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28734957/effect-of-schwertmannite-and-jarosite-on-the-formation-of-hypoxic-blackwater-during-inundation-of-grass-material
#2
Chamindra L Vithana, Leigh A Sullivan, Troy Shepherd
This study focused on understanding the effect of schwertmannite and jarosite, commonly found in floodplains containing acid sulfate soil materials, on the characteristics of the hypoxic blackwaters that can form when floodplain vegetation experiences prolonged inundation. The formation of these 'blackwaters' was simulated in the laboratory by inundating flood-intolerant pasture grass leaf material in both the presence of schwertmannite/jarosite (schwertmannite and jarosite treatments) minerals and their absence (control treatment) at 27...
July 17, 2017: Water Research
https://www.readbyqxmd.com/read/28734018/influence-of-cryoprecipitate-factor-xiii-and-fibrinogen-concentrate-on-hyperfibrinolysis
#3
Melissa M Cushing, Meghann M Fitzgerald, Rebecca M Harris, Lars M Asmis, Thorsten Haas
BACKGROUND: Hyperfibrinolysis is a potentially life-threatening condition associated with poor clot integrity and excessive bleeding. Although antifibrinolytics are an effective treatment, more liberal use of these drugs may lead to a prothrombotic risk, and an earlier and potentially safer treatment option would be desirable. Hyperfibrinolysis has been shown to be attenuated by in vitro supplementation of purified human Factor (F)XIII concentrate. Cryoprecipitate represents an alternative source of FXIII and the only approved source of concentrated FXIII in some countries...
July 21, 2017: Transfusion
https://www.readbyqxmd.com/read/28733969/tailoring-ion-charge-state-distribution-in-tetramethyltin-clusters-under-influence-of-moderate-intensity-picosecond-laser-pulse-role-of-laser-wavelength-and-rate-of-energy-deposition
#4
Pramod Sharma, Soumitra Das, Rajesh K Vatsa
Systematic manipulation of ionic-outcome in laser-cluster interaction process has been realized for studies carried out on tetramethyltin (TMT) clusters under picosecond laser conditions, determined by choice of laser wavelength and intensity. As a function of laser intensity, TMT clusters exhibit gradual enhancement in overall ionization of its cluster constituents, up to a saturation level of ionization, which was distinct for different wavelengths (266, 355, and 532 nm). Simultaneously, systematic appearance of higher multiply charged atomic ions and shift in relative abundance of multiply charged atomic ions towards higher charge state was observed, using time-of-flight mass spectrometer...
July 21, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28731107/a-fluorescent-turn-on-nanoprobe-for-simultaneous-visualization-of-dual-targets-involved-in-cell-apoptosis-and-drug-screening-in-living-cells
#5
Xiaolong Zhang, Naishun Liao, Geng Chen, Aixian Zheng, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
Herein, a novel dual-responsive two-color fluorescent nanoprobe has been designed for the fluorescence activation imaging of cell apoptosis in living cells. The nanoprobe consists of a gold nanoparticle core functionalized with a dense layer of DNA aptamers and peptides, which shows high affinity and specific response to cytochrome c (Cyt c) and caspase-3, respectively. The formation of the aptamer-Cyt c complex and the cleavage of the specific peptide by caspase-3 can liberate the dye labelled aptamers and peptides from the surface of gold nanoparticles, and then recover their fluorescence...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730807/cationic-carbon-dots-for-modification-free-detection-of-hyaluronidase-via-an-electrostatic-controlled-ratiometric-fluorescence-assay
#6
Weiqiang Yang, Jiancong Ni, Fang Luo, Wen Weng, Qiao-Hua Wei, Zhenyu Lin, Guonan Chen
Carbon dots (CDs) emerge as excellent fluorescent nanomaterials, but the full exploitation and application of their exceptional properties in the development of fluorescence assay are still rare. In this work, cationic carbon dots (C-CDs) covered with a plenty of positive charges on the surface were synthesized through a facile ultrasonic method. Negatively charged hyaluronic acid (HA) caused the aggregation of positively charged C-CDs and neutral red (NR) along its linear chain via electrostatic adsorption, leading to a remarkable förster resonance energy transfer (FRET) from C-CDs to NR...
July 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28729005/influence-of-late-fluid-management-on-the-outcomes-of-severe-trauma-patients-a-retrospective-analysis-of-294-severely-injured-patients
#7
Mehdi Mezidi, Mehdi Ould-Chikh, Pauline Deras, Camille Maury, Orianne Martinez, Xavier Capdevila, Jonathan Charbit
BACKGROUND: Liberal late fluid management (LFM) is associated with higher morbi-mortality in critically ill populations. The aim of the study was to assess the association between LFM and duration of mechanical ventilation in a severe trauma population. METHODS: A retrospective analysis of consecutive patients with an ISS≥16 and a length of stay in the intensive care unit (ICU)≥7 days was performed. The conservative LFM group included patients with at least 2 consecutive days with a negative fluid balance between day 3 and day 7; other patients were allocated to the liberal LFM group...
June 15, 2017: Injury
https://www.readbyqxmd.com/read/28728241/-petrous-bone-cholesteatoma-surgery-approach-and-outcomes
#8
R Y Wang, W J Han, T Zhang, W D Shen, J Liu, P Dai, S M Yang, D Y Han
Objective: To investigate the choice of surgical approach of petrous bone cholesteatoma (PBC)and surgical outcomes. Methods: A retrospective study was performed on 90 patients diagnosed and treated for PBC from January 2000 to December 2014 by the Chinese People's Liberation Army General Hospital otolaryngologists. According to Sanna's classification, 40 out of the 90 cases were supralabyrinthine, five infralabyrinthine, four infralabyrinthine-apical, 25 massive and 16 apical. Five cases underwent transmastoid and retrolabyrinthine approach, translabyrinthine approach was performed on six patients, 19 cases underwent subtotal petrosectomy, seven cases underwent transotic approach, 41 cases underwent middle fossa approach, combined transmastoid/middle fossa approach was performed on 11 cases, translabyrinthine and sphenoid sinus approach were performed on one case...
July 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28727925/investigating-the-relationship-between-social-and-economic-policy-views-firearm-ownership-and-death-by-firearm-in-a-sample-of-suicide-decedents
#9
Sarah E Butterworth, Claire Houtsma, Joye C Anestis, Michael D Anestis
Extant literature provides evidence for the frequent use and lethality of firearms in suicide and the ability of means safety measures to prevent suicides; however, little evidence exists to provide an understanding of the characteristics that differentiate suicide decedents who die by firearm from those who die by other methods. In this study, we build on prior findings regarding the characteristics of those who die by firearms by examining the relationship between social and economic policy views and both firearm ownership and death by firearm in a sample of 267 American suicide decedents...
July 20, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28727372/fosfomycin-a-good-alternative-drug-for-prostate-biopsy-prophylaxis-the-results-of-a-prospective-randomized-trial-with-respect-to-risk-factors
#10
Erdem Kisa, Mustafa Ugur Altug, Oguz Alp Gurbuz, Harun Ozdemir
PURPOSE: To determine the risk factors and the efficiency of rectal swab samples to prevent infectious complications in prostate biopsy, and compare fosfomycin with ciprofloxacin use in prophylaxis. MATERIALS AND METHODS: Between May and October 2014, pre-biopsy risk factors and their effect in ciprofloxacin and fosfomycin prophylaxis were determined. Pre-biopsy urinalysis, urine culture and rectal swab samples were obtained from all of the patients. Rectal swabs were obtained upon admission, and biopsy was performed in the following 3-7 days...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726906/influence-of-local-structure-on-photoluminescence-properties-of-eu-3-doped-ceo2-red-phosphors-through-induced-oxygen-vacancies-by-contrasting-rare-earth-substitutions
#11
Athira K V Raj, P Prabhakar Rao, T S Sreena, T R Aju Thara
A new family of red phosphors, Ce0.9-xRExO2-δ:0.1Eu(3+) (RE = Y and La; x = 0, 0.20, 0.40, 0.60, 0.80, and 0.90), was synthesized by a conventional solid-state route. The influence of contrasting rare earth substitutions (Y and La) in the system was investigated on the local structure and associated photoluminescence properties by various characterization techniques. Both trivalent ion substitutions lead to the same kind of variation during phase transformation from fluorite to the respective parent oxide structure (x ≥ 0...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726373/ultrasensitive-homogeneous-electrochemical-detection-of-transcription-factor-by-coupled-isothermal-cleavage-reaction-and-cycling-amplification-based-on-exonuclease-iii
#12
Lihua Lu, Huijuan Su, Feng Li
The assay and monitoring of transcription factors (TFs) has attracted extensive attention, due to their important roles in regulation of gene expressions. Herein, a simple, low cost, rapid, and highly sensitive homogeneous electrochemical method utilizing the coupled isothermal cleavage reaction and cycling amplification based on exonuclease III (Exo III) was explored for the analysis of transcription factor NF-κB p50 in aqueous solution. In the assay, a 3-methylene blue (MB)-labeled hairpin probe is designed, which can be opened up by the single stranded DNA (ssDNA) protected by NF-κB p50 from the Exo III cleavage, to trigger the subsequent Exo III-assisted digestion, thus a large amount of MB-labeled mononucleotides are liberated to result in the greatly amplified electrochemical signal...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28726082/undergraduate-minor-in-health-disparities-in-society-a-magnet-for-under-represented-pre-professional-students
#13
Laura K Guyer, Marta L Wayne, Nancy S Hardt
Increasing the diversity of tomorrow's healthcare work force remains a challenge despite many thoughtful published reports and recommendations. As part of an effort to grow a more diverse pre-professional health population, we created an undergraduate minor, Health Disparities in Society, at the University of Florida. Most courses for the minor were identified from existing offerings, and we created only two new courses, an introduction course and a capstone service-learning course. The new minor quickly became the most popular in the College of Liberal Arts and Sciences (which has approximately 12,000 total undergraduate students), and importantly, students selecting the minor were more likely to be under-represented minorities than would be expected given undergraduate demographics...
July 19, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28725284/addiction-and-moralization-the-role-of-the-underlying-model-of-addiction
#14
Lily E Frank, Saskia K Nagel
Addiction appears to be a deeply moralized concept. To understand the entwinement of addiction and morality, we briefly discuss the disease model and its alternatives in order to address the following questions: Is the disease model the only path towards a 'de-moralized' discourse of addiction? While it is tempting to think that medical language surrounding addiction provides liberation from the moralized language, evidence suggests that this is not necessarily the case. On the other hand non-disease models of addiction may seem to resuscitate problematic forms of the moralization of addiction, including, invoking blame, shame, and the wholesale rejection of addicts as people who have deep character flaws, while ignoring the complex biological and social context of addiction...
2017: Neuroethics
https://www.readbyqxmd.com/read/28724757/molecular-anatomy-of-the-early-events-in-stim1-activation-oligomerization-or-conformational-change
#15
Marek K Korzeniowski, Eva Wisniewski, Barbara Baird, David Holowka, Tamas Balla
Decreased luminal ER Ca(2+) concentration triggers oligomerization and clustering of the ER Ca(2+)-sensor, STIM1 to promote its association with plasma membrane Orai1 Ca(2+) channels leading to increased Ca(2+) influx. A key step in STIM1 activation is the release of its SOAR domain from an intramolecular clamp formed with the STIM1 first coiled-coil (CC1) region. Using a truncated STIM1(1-343) molecule that captures or releases the isolated SOAR domain depending on luminal ER Ca(2+) concentrations, we analyzed the early molecular events that control the intramolecular clamp formed between the CC1 and SOAR domains...
July 19, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28721127/diabetes-in-the-elderly
#16
REVIEW
Katarzyna Mordarska, Małgorzata Godziejewska-Zawada
The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycaemia are as follows: deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopaenia. Clinical features of diabetes in the elderly could be different. Diabetes in elderly people is often diagnosed with delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycaemia...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28720673/challenges-with-implementation-of-a-respiratory-therapist-driven-protocol-of-spontaneous-breathing-trials-in-the-pediatric-icu
#17
Conrad Krawiec, Dale Carl, Christy Stetter, Lan Kong, Gary D Ceneviva, Neal J Thomas
BACKGROUND: Timely ventilator liberation is crucial in the pediatric ICU. In many pediatric ICUs, the decision to initiate weaning is driven by the physician, which may lead to delays in ventilator liberation. The objectives of this quality improvement project were to develop and implement a respiratory therapist (RT)-led protocol for screening for spontaneous breathing trial (SBT) readiness, to test protocol feasibility, and to evaluate its impact on SBT timing. METHODS: A retrospective chart review was performed on all intubated patients in the pediatric ICU for 18 months prior to protocol institution...
July 18, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28719853/determination-of-chemical-forms-of-14-c-in-liquid-discharges-from-nuclear-power-plants
#18
I Svetlik, M Fejgl, P P Povinec, T Kořínková, L Tomášková, J Pospíchal, M Kurfiřt, R Striegler, M Kaufmanová
Developments of radioanalytical methods for determination of radiocarbon in wastewaters from nuclear power plants (NPP) with pressurized light water reactors, which would distinguish between the dissolved organic and inorganic forms have been carried out. After preliminary tests, the method was used to process pilot samples from wastewater outlets from the Temelín and Dukovany NPPs (Czech Republic). The results of analysis of pilot water samples collected in 2015 indicate that the instantaneous (14)C releases into the water streams would be about 7...
July 15, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28718880/-i-just-don-t-want-to-connect-my-life-with-this-occupation-working-class-young-men-manual-labour-and-social-mobility-in-contemporary-russia
#19
Charlie Walker
A key strand in the Western literature on working-class masculinities focuses on whether young men are capable of the feminized performances apparently required of them in new service economies. However, the wider literature on processes of neoliberalization - emphasizing the 'hollowing out' of labour markets, the cultural devaluation of lower-skilled forms of employment, and the pathologization of working-class lives - would suggest that it is as much a classed as a gendered transformation that is demanded of young men leaving school with few qualifications...
July 18, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28711301/the-taxation-of-unhealthy-energy-dense-foods-edfs-and-sugar-sweetened-beverages-ssbs-an-overview-of-patterns-observed-in-the-policy-content-and-policy-context-of-13-case-studies
#20
REVIEW
Luc Louis Hagenaars, Patrick Paulus Theodoor Jeurissen, Niek Sieds Klazinga
Taxation of energy-dense foods (EDFs) and sugar-sweetened beverages (SSBs) is increasingly of interest as a novel public health and fiscal policy instrument. However academic interest in policy determinants has remained limited. We address this paucity by comparing the policy content and policy context of EDF/SSB taxes witnessed in 13 case studies, of which we assume the tax is sufficiently high to induce behavioural change. The observational and non-randomized studies published on our case studies seem to indicate that the EDF/SSB taxes under investigation generally had the desired effects on prices and consumption of targeted products...
July 8, 2017: Health Policy
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