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https://www.readbyqxmd.com/read/28231560/the-expanding-role-of-immunotherapy
#1
REVIEW
Juan Martin-Liberal, María Ochoa de Olza, Cinta Hierro, Alena Gros, Jordi Rodon, Josep Tabernero
The use of agents able to modulate the immune system to induce or potentiate its anti-tumour activity is not a new strategy in oncology. However, the development of new agents such as immune checkpoint inhibitors has achieved unprecedented efficacy results in a wide variety of tumours, dramatically changing the landscape of cancer treatment in recent years. Ipilimumab, nivolumab, pembrolizumab or atezolizumab are now standard of care options in several malignancies and new indications are being approved on a regular basis in different tumours...
February 11, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28230629/point-of-injury-tourniquet-application-during-operation-protective-edge-what-de-we-learn
#2
Amir Shlaifer, Avraham Yitzhak, Erez N Baruch, Avi Shina, Alexandra Satanovsky, Amiram Shovali, Ofer Almog, Elon Glassberg
BACKGROUND: Hemorrhage is a leading cause of preventable death on the battlefield. Timely tourniquet application to massively bleeding extremity wounds is critical for casualty survival albeit with reported adverse effects to extremity integrity. The aim of this study was to describe the immediate and short term outcomes of point of injury (POI) tourniquet applications during 'Operation Protective Edge' (OPE). METHODS: A case series study regarding tourniquet application at the POI during OPE was collected...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28230460/meditation-and-hypnosis-two-sides-of-the-same-coin
#3
Enrico Facco
Hypnosis and meditation, as a whole, form a heterogeneous complex of psychosomatic techniques able to control mind and body regulation. Hypnosis has been pragmatically used for limited therapeutic targets, while Eastern meditation has much wider philosophical and existential implications, aiming for a radical liberation from all illusions, attachments, suffering and pain. The available data on the history, phenomenology, and neuropsychology of hypnosis and meditation show several common features, such as the following: (a) induction based on focused attention; (b) capability to reach an intentional control of both biologic-somatic activities and conscious-unconscious processes;...
April 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28228122/high-dose-chemotherapy-and-autologous-stem-cell-transplantation-of-patients-with-multiple-myeloma-in-an-outpatient-setting
#4
Katharina Lisenko, Sandra Sauer, Thomas Bruckner, Gerlinde Egerer, Hartmut Goldschmidt, Jens Hillengass, Johann W Schmier, Sofia Shah, Mathias Witzens-Harig, Anthony D Ho, Patrick Wuchter
BACKGROUND: High-dose (HD) chemotherapy with melphalan and autologous blood stem cell transplantation (ABSCT) for treatment of symptomatic multiple myeloma (MM) on an outpatient basis has been well established in the USA and Canada, whereas in Germany and Western Europe an inpatient setting is the current standard. We report on a German single-centre program to offer the procedure on an outpatient basis to selected patients. METHODS: Major requirements included: patients had to have family and/or other caregivers, had to be able to reach the hospital within 45 min and have an ECOG performance score of 0-1...
February 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28227771/tracking-intrinsic-connectivity-brain-network-features-during-successive-pseudo-resting-states-and-interoceptive-task-fmri
#5
Behnaz Jarrahi, Dante Mantini, Behnaz Jarrahi, Dante Mantini, Behnaz Jarrahi, Dante Mantini
Advanced multivariate analyses of functional magnetic resonance imaging (fMRI) data based on blood oxygen level-dependent (BOLD) contras have revealed that the human brain organizes its activities into multiple intrinsic connectivity networks (ICNs). Several fMRI studies have evaluated the modulations of these networks during different cognitive or emotional tasks using blind source separation techniques particularly the independent component analysis (ICA). In this exploratory study, we applied ICA methodology to examine ICN modulations under different interoceptive conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227126/cardiac-muscle-energetics-improved-normalisation-of-heat-using-optical-coherence-tomography
#6
Ming L Cheuk, Callum M Johnston, June-Chiew Han, Denis S Loiselle, Poul M F Nielsen, Andrew J Taberner, Ming L Cheuk, Callum M Johnston, June-Chiew Han, Denis S Loiselle, Poul M F Nielsen, Andrew J Taberner, June-Chiew Han, Callum M Johnston, Poul M F Nielsen, Ming L Cheuk, Denis S Loiselle, Andrew J Taberner
Heat liberated from isolated cardiac muscle has been used to inform us of thermo-mechanical processes that occur during a contraction. However, for comparisons between different samples to be useful, the heat output needs to be normalized to volume. We have implemented an optical coherence tomograph (OCT), together with a flow-through calorimeter, to accurately determine both muscle volume and heat in the same measurement chamber. The heat rate for multiple stimulation frequencies were recorded and normalized to the volume captured by the OCT...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226353/-comparison-of-complications-following-open-laparoscopic-and-robotic-gastrectomy
#7
Xin Lan, Hongqing Xi, Kecheng Zhang, Jianxin Cui, Mingsen Li, Lin Chen
OBJECTIVE: To compare clinically relevant postoperative complications after open, laparoscopic, and robotic gastrectomy for gastric cancer. METHODS: Clinical data of patients with gastric cancer who underwent gastrectomy between January 1, 2014 and October 1, 2016 at Chinese People's Liberation Army General Hospital were analyzed retrospectively. All the patients were diagnosed by upper endoscopy and confirmed by biopsy without distant metastasis. They were confirmed with R0 resection by postoperative pathology...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28226336/educational-outreach-to-opioid-prescribers-the-case-for-academic-detailing
#8
Margot Trotter Davis, Brian Bateman, Jerry Avorn
Nonmedical use of opioid medications constitutes a serious health threat as the rates of addiction, overdoses, and deaths have risen in recent years. Increasingly, inappropriate and excessively liberal prescribing of opioids by physicians is understood to be a central part of the crisis. Public health officials, hospital systems, and legislators are developing programs and regulations to address the problem in sustained and systematic ways that both insures effective treatment of pain and appropriate limits on the availability of opioids...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28226301/the-influence-of-welfare-systems-on-pay-for-performance-programs-for-general-practitioners-a-critical-review
#9
REVIEW
Mehdi Ammi, Grant Fortier
While pay-for-performance (P4P) programs are increasingly common tools used to foster quality and efficiency in primary care, the evidence concerning their effectiveness is at best mixed. In this article, we explore the influence of welfare systems on four P4P-related dimensions: the level of healthcare funders' commitment to P4Ps (by funding and length of program operation), program design (specifically target-based vs. participation-based program), physicians' acceptance of the program and program effects...
February 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28225252/luminescent-re-i-carbonyl-complexes-as-trackable-photocorms-for-co-delivery-to-cellular-targets
#10
Indranil Chakraborty, Jorge Jimenez, W M C Sameera, Masako Kato, Pradip K Mascharak
A family of Re(I) carbonyl complexes of general formula [ReX(CO)3(phen)](0/1+) (where X = Cl(-), CF3SO3(-), MeCN, PPh3, and methylimidazole) derived from 1,10-phenanthroline (phen) exhibits variable emission characteristics depending on the presence of the sixth ancillary ligand/group (X). All complexes but with X = MeCN exhibit moderate CO release upon irradiation with low-power UV light and are indefinitely stable in anaerobic/aerobic environment in solution as well as in solid state when kept under dark condition...
February 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28224336/influence-of-silver-nanoparticles-and-liberated-silver-ions-on-nitrifying-sludge-ammonia-oxidation-inhibitory-kinetics-and-mechanism
#11
Nguyen Thanh Giao, Tawan Limpiyakorn, Pattaraporn Kunapongkiti, Pumis Thuptimdang, Sumana Siripattanakul-Ratpukdi
Silver nanoparticles (AgNPs) are widely used in commercial products because of their excellent antimicrobial activity. Entrance of AgNPs and its released Ag ions (Ag(+)) into wastewater treatment plants could harm ammonia oxidation (AO) process resulting in environmental problems. This study investigated inhibitory kinetics and mechanism of AO from nitrifying sludge influenced by AgNPs and Ag(+). The findings demonstrated that AgNPs and Ag(+) adversely influenced on AO. Silver ions were more toxic to AO than AgNPs, which was indicated by the lower inhibitory constant (K i ) of 0...
February 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28224195/paenibacillus-sp-598k-6-%C3%AE-glucosyltransferase-is-essential-for-cycloisomaltooligosaccharide-synthesis-from-%C3%AE-1%C3%A2-%C3%A2-%C3%A2-4-glucan
#12
Hitomi Ichinose, Ryuichiro Suzuki, Takatsugu Miyazaki, Keitarou Kimura, Mitsuru Momma, Nobuhiro Suzuki, Zui Fujimoto, Atsuo Kimura, Kazumi Funane
Paenibacillus sp. 598K produces cycloisomaltooligosaccharides (cyclodextrans) from starch even in the absence of dextran. Cycloisomaltooligosaccharide glucanotransferase synthesizes cycloisomaltooligosaccharides exclusively from an α-(1 → 6)-consecutive glucose chain consisting of at least four molecules. Starch is not a substrate of this enzyme. Therefore, we predicted that the bacterium possesses another enzyme system for extending α-(1 → 6)-linked glucoses from starch, which can be used as the substrate for cycloisomaltooligosaccharide glucanotransferase, and identified the transglucosylation enzyme Ps6GT31A...
February 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28221702/localized-and-controlled-delivery-of-nitric-oxide-to-the-conventional-outflow-pathway-via-enzyme-biocatalysis-toward-therapy-for-glaucoma
#13
Rona Chandrawati, Jason Y H Chang, Ester Reina-Torres, Coline Jumeaux, Joseph M Sherwood, W Daniel Stamer, Alexander N Zelikin, Darryl R Overby, Molly M Stevens
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. An NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28221092/social-and-economic-ideologies-differentially-predict-prejudice-across-the-political-spectrum-but-social-issues-are-most-divisive
#14
Jarret T Crawford, Mark J Brandt, Yoel Inbar, John R Chambers, Matt Motyl
Liberals and conservatives both express prejudice toward ideologically dissimilar others (Brandt et al., 2014). Previous work on ideological prejudice did not take advantage of evidence showing that ideology is multidimensional, with social and economic ideologies representing related but separable belief systems. In 5 studies (total N = 4912), we test 3 competing hypotheses of a multidimensional account of ideological prejudice. The dimension-specific symmetry hypothesis predicts that social and economic ideologies differentially predict prejudice against targets who are perceived to vary on the social and economic political dimensions, respectively...
March 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28220822/pulmonary-outcomes-following-specialized-respiratory-management-for-acute-cervical-spinal-cord-injury-a-retrospective-analysis
#15
E C Zakrasek, J L Nielson, J J Kosarchuk, J D Crew, A R Ferguson, S L McKenna
STUDY DESIGN: Retrospective analysis. OBJECTIVES: To identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increase successful liberation from mechanical ventilation. SETTING: United States regional spinal cord injury (SCI) treatment center. METHODS: Retrospective chart review of patients consecutively admitted to Santa Clara Valley Medical Center between May 2013 and December 2014 for ventilator weaning with C1-C5 American Spinal Injury Association Impairment Scale (AIS) A or B SCI, <3 months from injury and who had a tracheostomy in place...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220693/aroma-precursors-in-grapes-and-wine-flavor-release-during-wine-production-and-consumption
#16
Mango Parker, Dimitra L Capone, I Leigh Francis, Markus J Herderich
Pioneering investigations into precursors to fruity and floral flavors established the importance of terpenoid and C13-norisoprenoid glycosides to the flavor of aromatic wines. Nowadays flavor precursors in grapes and wine are known to be structurally diverse, encompassing glycosides; amino acid conjugates; odorless volatiles; hydroxycinnamic acids and many others. Flavor precursors mainly originate in the grape berry, but also from oak or other materials involved in winemaking. Flavors are released from precursors during crushing and subsequent production steps by enzymatic and non-enzymatic transformations, via microbial glycosidases; esterases; C-S lyases and decarboxylases; and through acid catalysed hydrolysis and chemical rearrangements...
February 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28220499/three-year-follow-up-of-implementation-of-evidence-based-transfusion-practice-in-a-tertiary-hospital
#17
A Norgaard, J Stensballe, T H de Lichtenberg, J O White, A Perner, M Wanscher, J Hillingsø, M L Holm, M Mau-Sørensen, H Sillesen, L Kjeldsen, C Bäck, J Nielsen, J Seeberg, M B Hansen, P I Johansson
BACKGROUND AND OBJECTIVES: Traditionally, Denmark has had a high rate of allogeneic red blood cell transfusion caused by a liberal transfusion practice despite the existence of restrictive guidelines. We established a Patient Blood Management programme in a tertiary hospital and report the results of the implementation of evidence-based transfusion practice. MATERIALS AND METHODS: Red blood cell transfusion quality indicators were compared with the evidence-based guideline at hospital and department level...
February 20, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28219995/magnetic-field-concentration-assisted-by-epsilon-near-zero-media
#18
Iñigo Liberal, Yue Li, Nader Engheta
Strengthening the magnetic response of matter at optical frequencies is of fundamental interest, as it provides additional information in spectroscopy, as well as alternative mechanisms to manipulate light at the nanoscale. Here, we demonstrate theoretically that epsilon-near-zero (ENZ) media can enhance the magnetic field concentration capabilities of dielectric resonators. We demonstrate that the magnetic field enhancement factor is unbounded in theory, and it diverges as the size of the ENZ host increases...
March 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28219376/cooperate-a-paradigm-shift-for-health-equity
#19
REVIEW
Wei-Ching Chang, Joy H Fraser
The role of competition and cooperation in relation to the goal of health equity is examined in this paper. The authors explain why the win-lose mentality associated with avoidable competition is ethically questionable and less effective than cooperation in achieving positive outcomes, particularly as it relates to health and health equity. Competition, which differentiates winners from losers, often with the winner-takes-all reward system, inevitably leads to a few winners and many losers, resulting in social inequality, which, in turn, engenders and perpetuates health inequity...
February 21, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28219085/fibrinolysis-in-trauma-myth-reality-or-something-in-between
#20
Mark Walsh, Jacob Shreve, Scott Thomas, Ernest Moore, Hunter Moore, Daniel Hake, Tim Pohlman, Patrick Davis, Victoria Ploplis, Andres Piscoya, Julie Wegner, John Bryant, Anton Crepinsek, James Lantry, Forest Sheppard, Francis Castellino
The emphasis on fibrinolysis as an important contributor to trauma-induced coagulopathy (TIC) has led to a debate regarding the relative clinical significance of fibrinolysis in the setting of trauma. The debate has centered on two camps. The one camp defines fibrinolysis in trauma by standard coagulation tests as well as fibrin split products, D-dimers, and plasmin/antiplasmin levels. This camp favors a more liberal use of tranexamic acid and attributes more significance to hyperfibrinolysis in TIC. The other camp favors a definition of fibrinolysis based on the viscoelastic tests (VET), rotational thromboelastometry (ROTEM), and thromboelastography (TEG)...
February 20, 2017: Seminars in Thrombosis and Hemostasis
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