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https://www.readbyqxmd.com/read/28087531/salivary-gluten-degradation-and-oral-microbial-profiles-in-health-and-celiac-disease
#1
Na Tian, Lina Faller, Daniel A Leffler, Ciaran P Kelly, Joshua Hansen, Jos A Bosch, Guoxian Wei, Bruce J Paster, Detlef Schuppan, Eva J Helmerhorst
: Celiac disease (CD) is a chronic immune-mediated enteropathy induced by dietary gluten in genetically predisposed individuals. Saliva harbors the second highest bacterial load of the GI tract after the colon. Moreover, saliva contains gluten-degrading enzymes produced by oral bacteria that may modify gluten processing in the intestine and susceptibility to celiac disease (CD). AIM: To investigate salivary enzymatic activities and oral microbial profiles in healthy subjects vs patients with classical and refractory CD...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28086792/irish-general-practitioner-attitudes-toward-decriminalisation-and-medical-use-of-cannabis-results-from-a-national-survey
#2
Des Crowley, Claire Collins, Ide Delargy, Eamon Laird, Marie Claire Van Hout
BACKGROUND: Governmental debate in Ireland on the de facto decriminalisation of cannabis and legalisation for medical use is ongoing. A cannabis-based medicinal product (Sativex®) has recently been granted market authorisation in Ireland. This unique study aimed to investigate Irish general practitioner (GP) attitudes toward decriminalisation of cannabis and assess levels of support for use of cannabis for therapeutic purposes (CTP). METHODS: General practitioners in the Irish College of General Practitioner (ICGP) database were invited to complete an online survey...
January 13, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28081552/demographic-and-psychological-correlates-of-new-zealanders-support-for-euthanasia
#3
Carol Hj Lee, Isabelle M Duck, Chris G Sibley
AIMS: To explore the distribution of New Zealanders' support towards the legalisation of euthanasia and examine demographic and psychological factors associated with these attitudes. METHODS: 15,822 participants responded to the 2014/15 New Zealand Attitudes and Values Study (NZAVS) survey. This survey included an item on people's attitudes towards euthanasia, and information on their demographic and psychological characteristics. RESULTS: The majority of New Zealanders expressed support for euthanasia, which was assessed by asking "Suppose a person has a painful incurable disease...
January 13, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28079944/an-isolable-silicon-dicarbonate-complex-from-carbon-dioxide-activation-with-a-silylone
#4
Alexander Burchert, Shenglai Yao, Robert Müller, Caspar Schattenberg, Yun Xiong, Martin Kaupp, Matthias Driess
The first isolable molecular silicon dicarbonate complex (bis-NHC)Si(CO3 )2 2 (bis-NHC=H2 C[{NC(H)=C(H)N(Dipp)}C:]2 , Dipp=2,6-iPr2 C6 H3 ) was synthesized by facile reaction of the bis-N-heterocyclic carbene stabilized silylone (bis-NHC)Si 1, bearing a zero-valent silicon atom, with carbon dioxide. The monomeric silicon dioxide complex (bis-NHC)SiO2 3 supported by the bis-NHC ligand was proposed as a key intermediate resulting from double oxygenation of the zero-valent silicon atom in 1 by two molar equivalents of CO2 under liberation of CO; its subsequent Lewis acid-base reaction with CO2 leads to 2 which has been fully characterized including an single-crystal X-ray diffraction analysis...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28077628/the-creatininase-homolog-mfte-from-mycobacterium-smegmatis-catalyzes-a-peptide-cleavage-reaction-in-the-biosynthesis-of-a-novel-ripp
#5
Nathan A Bruender, Vahe Bandarian
Most ribosomally-synthesized and post-translationally modified peptide (RiPP) natural products are processed by tailoring enzymes to create complex natural products that are still recognizably peptide-based. However, some tailoring enzymes dismantle the peptide en route to synthesis of small molecules. The biosynthesis of a small-molecule natural product of as yet unknown structure, mycofactocin, is thought to be synthesized in this way, via the mft gene cluster found in many strains of Mycobacteria. This cluster harbors at least six genes, which appear to be conserved across species...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28077573/a-retrochaperone-function-for-cdc48-the-cdc48-complex-is-required-for-retrotranslocated-erad-m-substrate-solubility
#6
Sonya E Neal, Raymond Mak, Eric J Bennett, Randolph Hampton
A surprising feature of ER-associated degradation (ERAD) is the movement, or retrotranslocation, of ubiquitinated substrates from the ER lumen or membrane to the cytosol where they are degraded by the 26S proteasome. Multispanning ER membrane proteins, called ERAD-M substrates, are retrotranslocated to the cytosol as full-length intermediates during ERAD and we have investigated how they maintain solubility. Using an in vivo assay, we show that retrotranslocated ERAD-M substrates are moved to the cytoplasm as part of the normal ERAD pathway, where they are part of a solely proteinacious complex...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28076978/abortion-services-at-hospitals-in-istanbul
#7
Mary Lou O'Neil
OBJECTIVE: Despite the existence of a liberal law on abortion in Turkey, there is growing evidence that actually securing an abortion in Istanbul may prove difficult. This study aimed to determine whether or not state hospitals and private hospitals that accept state health insurance in Istanbul are providing abortion services and for what indications. METHOD: Between October and December 2015, a mystery patient telephone survey of 154 hospitals, 43 public and 111 private, in Istanbul was conducted...
January 12, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28076368/functional-laterality-of-task-evoked-activation-in-sensorimotor-cortex-of-preterm-infants-an-optimized-3-t-fmri-study-employing-a-customized-neonatal-head-coil
#8
Lukas Scheef, Jurek A Nordmeyer-Massner, Adam Pr Smith-Collins, Nicole Müller, Gaby Stegmann-Woessner, Jacob Jankowski, Jürgen Gieseke, Mark Born, Hermann Seitz, Peter Bartmann, Hans H Schild, Klaas P Pruessmann, Axel Heep, Henning Boecker
BACKGROUND: Functional magnetic resonance imaging (fMRI) in neonates has been introduced as a non-invasive method for studying sensorimotor processing in the developing brain. However, previous neonatal studies have delivered conflicting results regarding localization, lateralization, and directionality of blood oxygenation level dependent (BOLD) responses in sensorimotor cortex (SMC). Amongst the confounding factors in interpreting neonatal fMRI studies include the use of standard adult MR-coils providing insufficient signal to noise, and liberal statistical thresholds, compromising clinical interpretation at the single subject level...
2017: PloS One
https://www.readbyqxmd.com/read/28075130/expression-and-characterization-of-levansucrase-from-clostridium-acetobutylicum
#9
Song Gao, Xianghui Qi, Darren J Hart, Herui Gao, Yingfeng An
The Clostridium acetobutylicum gene Ca-SacB encoding levansucrase was cloned and expressed in Escherichia coli. Ca-SacB is composed of 1287 bp and encodes 428 amino acid residues, which could convert 150 mmol/L sucrose to levan with the liberation of glucose. The optimum pH and temperature of this enzyme for levan formation were pH 6 and 60℃, respectively. Levansucrase activity of Ca-SacB was completely abolished by 5 mmol/L Ag+ and Hg2+. The Km and Vmax values for levansucrase were calculated to be 64 mmol/L and 190 µmol/min/mg, respectively...
January 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28072958/-investigation-on-immunization-program-coverage-rate-and-its-safety-in-children-with-tuberous-sclerosis
#10
Y Gao, L P Zou, M N Zhang, L Y Pang, Y Y Wang, S F Ma, L L Huang
Objective: To investigate the status of immunization of National Immunization Program (NIP) and its adverse reaction rate in children with tuberous sclerosis. Method: Questionnaire survey was adopted to identify the vaccination coverage and its adverse events; 72 cases of children with tuberous sclerosis and 78 normal controls (healthy children completing age-appropriate NIP) admitted to Chinese People's Liberation Army General Hospital from December 2014 to November 2015 were involved into this study. Result: The age-appropriate NIP coverage rate of tuberous sclerosis was 36%(26/72)...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28071846/trapping-rare-and-elusive-phosphinidene-chalcogenides
#11
Cameron M E Graham, Taylor E Pritchard, Paul D Boyle, Juuso Valjus, Heikki M Tuononen, Paul J Ragogna
Four-membered rings with a P2 Ch2 core (Ch=S, Se) and phosphorus in the +3 oxidation state have been synthesized. The utility of these rings as a source of monomeric phosphinidene chalcogenides was probed by the addition of an N-heterocyclic carbene, resulting in a base-stabilized phosphinidene sulfide. Similarly, persistence of the phosphinidene selenide in solution was shown through cycloaddition chemistry with 2,3-dimethylbutadiene at elevated temperatures. The observed reactivity was explained by detailed computational work that established the conditions upon which the P2 Ch2 rings can liberate phosphinidene chalcogenides...
January 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28070222/scale-up-and-process-integration-of-sugar-production-by-acidolysis-of-municipal-solid-waste-corn-stover-blends-in-ionic-liquids
#12
Chenlin Li, Ling Liang, Ning Sun, Vicki S Thompson, Feng Xu, Akash Narani, Qian He, Deepti Tanjore, Todd R Pray, Blake A Simmons, Seema Singh
BACKGROUND: Lignocellulosic biorefineries have tonnage and throughput requirements that must be met year round and there is no single feedstock available in any given region that is capable of meeting the price and availability demands of the biorefineries scheduled for deployment. Significant attention has been historically given to agriculturally derived feedstocks; however, a diverse range of wastes, including municipal solid wastes (MSW), also have the potential to serve as feedstocks for the production of advanced biofuels and have not been extensively studied...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28068476/phosphorus-fate-and-dynamics-in-greywater-biofiltration-systems
#13
Harsha S Fowdar, Belinda E Hatt, Tom Cresswell, Jennifer J Harrison, Perran Louis Miall Cook, Ana Deletic
Phosphorus, a critical environmental pollutant, is effectively removed from stormwater by biofiltration systems, mainly via sedimentation and straining. However, the fate of dissolved inflow phosphorus concentrations in these systems is unknown. Given the growing interest in using biofiltration systems to treat other polluted waters, for example greywater, such an understanding is imperative to optimise designs for successful long-term performance. A mass balance method and a radiotracer, 32P (as H3PO4), were used to investigate the partitioning of phosphorus (concentrations of 2...
January 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28067544/restrictive-versus-liberal-blood-transfusion-in-patients-with-coronary-artery-disease-a-meta-analysis
#14
Yushu Wang, Xiuli Shi, Meiqin Wen, Yucheng Chen, Qing Zhang
OBJECTIVES: To compare clinical outcomes between restrictive versus liberal blood transfusion strategies in patients with coronary artery disease (CAD). RESEARCH DESIGN AND METHODS: A literature search from January 1966 to May 2016 was performed in Pubmed, EMBASE and Cochrane Library to find trials evaluating a restrictive hemoglobin transfusion trigger of ≤8 g/dL, compared with a more liberal trigger. Two study authors independently extracted data from the trials...
January 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28067008/histidine-rich-designer-peptides-of-the-lah4-family-promote-cell-delivery-of-a-multitude-of-cargo
#15
Gilles Moulay, Christian Leborgne, A James Mason, Christopher Aisenbrey, Antoine Kichler, Burkhard Bechinger
The histidine-rich designer peptides of the LAH4 family exhibit potent antimicrobial, transfection, transduction and cell-penetrating properties. They form non-covalent complexes with their cargo, which often carry a negative overall charge at pH 7.4 and include a large range of molecules and structures such as oligonucleotides, including siRNA and DNA, peptides, proteins, nanodots and adeno-associated viruses. These complexes are thought to enter the cells through an endosomal pathway where the acidification of the organelle is essential for efficient endosomal escape...
January 9, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28065775/group-focused-morality-is-associated-with-limited-conflict-detection-and-resolution-capacity-neuroanatomical-evidence
#16
Kyle Nash, Thomas Baumgartner, Daria Knoch
Group-focused moral foundations (GMFs) - moral values that help protect the group's welfare - sharply divide conservatives from liberals and religiously devout from non-believers. However, there is little evidence about what drives this divide. Moral foundations theory and the model of motivated social cognition both associate group-focused moral foundations with differences in conflict detection and resolution capacity, but in opposing directions. Individual differences in conflict detection and resolution implicate specific neuroanatomical differences...
January 5, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28065368/a-randomised-clinical-trial-of-routine-versus-selective-ct-imaging-in-acute-abdomen-impact-of-patient-age-on-treatment-costs-and-hospital-resource-use
#17
Tiina T Lehtimäki, Hannu Valtonen, Pekka Miettinen, Petri Juvonen, Hannu Paajanen, Ritva Vanninen
OBJECTIVES: To evaluate the impact of patient age on hospital resource use and treatment costs of acute abdominal pain (AAP). MATERIALS AND METHODS: A total of 300 adult patients with AAP were randomised to either computed tomography (CT, n=150) or selective imaging practice (SIP, n=150) groups. Final analysis included 254 patients, 143 (42 patients ≥65years) in the CT and 111 (32 patients ≥65years) in the SIP group. All CT group patients underwent abdominal CT whereas in the SIP group, imaging was based on the clinical assessment...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28064363/morphometric-and-mechanical-characteristics-of-equisetum-hyemale-stem-enhance-its-vibration
#18
Urszula Zajączkowska, Stanisław Kucharski, Zdzisław Nowak, Kamila Grabowska
The order of the internodes, and their geometry and mechanical characteristics influence the capability of the Equisetum stem to vibrate, potentially stimulating spore liberation at the optimum stress setting along the stem. Equisetum hyemale L. plants represent a special example of cellular solid construction with mechanical stability achieved by a high second moment of area and relatively high resistance against local buckling. We proposed the hypothesis that the order of E. hyemale L. stem internodes, their geometry and mechanical characteristics influence the capability of the stem to vibrate, stimulating spore liberation at the minimum stress setting value along the stem...
January 7, 2017: Planta
https://www.readbyqxmd.com/read/28063433/elucidating-the-energetic-contributions-to-the-binding-free-energy
#19
Mazen Ahmad, Volkhard Helms, Olga V Kalinina, Thomas Lengauer
New exact equations are derived for the terms contributing to the binding free energy (ΔG(0)) of a ligand-receptor pair using our recently introduced formalism which we here call perturbation-divergence formalism (PDF). Specifically, ΔG(0) equals the sum of the average of the perturbation (pertaining to new interactions) and additional dissipative terms. The average of the perturbation includes the sum of the average receptor-ligand interactions and the average of the change of solvation energies upon association...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28062357/development-qualification-validation-and-application-of-the-neutral-red-uptake-assay-in-chinese-hamster-ovary-cho-cells-using-a-vitrocell%C3%A2-vc10%C3%A2-smoke-exposure-system
#20
Wanda Fields, Kathy Fowler, Victoria Hargreaves, Lesley Reeve, Betsy Bombick
: Cytotoxicity assessment of combustible tobacco products by neutral red uptake (NRU) has historically used total particulate matter (TPM) or solvent captured gas vapor phase (GVP), rather than fresh whole smoke. Here, the development, validation and application of the NRU assay in Chinese Hamster Ovary (CHO) cells, following exposure to fresh whole smoke generated with the VITROCELL® VC10® system is described. Whole smoke exposure is particularly important as both particulate and vapor phases of tobacco smoke show cytotoxicity in vitro...
January 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
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