Victoria S Marshe, Malgorzata Maciukiewicz, Anne-Christin Hauschild, Farhana Islam, Li Qin, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Alastair J Flint, Gustavo Turecki, Raymond W Lam, Roumen V Milev, Benicio N Frey, Susan Rotzinger, Jane A Foster, Sidney H Kennedy, James L Kennedy, Benoit H Mulsant, Charles F Reynolds, Eric J Lenze, Daniel J Müller
Antidepressant outcomes in older adults with depression is poor, possibly because of comorbidities such as cerebrovascular disease. Therefore, we leveraged multiple genome-wide approaches to understand the genetic architecture of antidepressant response. Our sample included 307 older adults (≥60 years) with current major depression, treated with venlafaxine extended-release for 12 weeks. A standard genome-wide association study (GWAS) was conducted for post-treatment remission status, followed by in silico biological characterization of associated genes, as well as polygenic risk scoring for depression, neurodegenerative and cerebrovascular disease...
February 15, 2021: Translational Psychiatry