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https://www.readbyqxmd.com/read/28628842/matching-genomic-molecular-aberrations-with-molecular-targeted-agents-are-biliary-tract-cancers-an-ideal-playground
#1
REVIEW
Loic Verlingue, Antoine Hollebecque, Valérie Boige, Michel Ducreux, David Malka, Charles Ferté
Biliary tract cancers (BTCs) are a heterogeneous group of tumours with geographical discrepancies in terms of incidence and risk factors. However, a convergent genomic and epigenetic mutational landscape emerges from the genome-wide screens of BTCs in South East Asia, Latin America and in the Western World. Specificities are observed for some alterations and anatomical subtypes: frequent fibroblast growth factor receptor 2 (FGFR2) and isocitrate dehydrogenase 1/2 (IDH1/2) alterations are specific to intrahepatic cholangiocarcinomas (ICCs), whereas frequent ERBB2 oncogene alterations are specific to extrahepatic cholangiocarcinomas (ECCs) and gallbladder carcinomas (GBCs)...
June 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28618544/dynamics-of-a-mechanical-system-with-multiple-degrees-of-freedom-out-of-thermal-equilibrium
#2
A Feigel
Out of thermal equilibrium, an environment imposes effective mechanical forces on nanofabricated devices as well as on microscopic chemical or biological systems. Here we address the question of how to calculate these forces together with the response of the system from first principles. We show that an ideal gaslike environment, even near thermal equilibrium, can enforce a specific steady state on the system by creating effective potentials in otherwise homogeneous space. An example of stable and unstable rectifications of thermal fluctuations is presented using a modified Feynman-Smoluchowski ratchet with two degrees of freedom...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28609189/a-new-kid-on-the-playground-of-crispr-dmd-therapy
#3
Dongsheng Duan
No abstract text is available yet for this article.
June 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28592241/effect-of-major-school-playground-reconstruction-on-physical-activity-and-sedentary-behaviour-camden-active-spaces
#4
Mark Hamer, Daniel Aggio, Georgina Knock, Courtney Kipps, Aparna Shankar, Lee Smith
BACKGROUND: The physical school environment is a promising setting to increase children's physical activity although robust evidence is sparse. We examined the effects of major playground reconstruction on physical activity and sedentary time in primary schools using a quasi-experimental design (comparison group pre-test/post-test design). METHODS: Five experimental and two control schools from deprived areas of inner city London were recruited at baseline. Main outcome was physical activity and sedentary time measured from objective monitoring (Actigraph accelerometer) at one year follow up...
June 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28588104/a-content-analysis-of-outdoor-non-alcoholic-beverage-advertisements-in-ghana
#5
Marie A Bragg, Tamara Hardoby, Natasha G Pandit, Yemi R Raji, Gbenga Ogedegbe
OBJECTIVES: This was a two-part descriptive study designed to (1) assess the marketing themes and sugar content of beverages promoted in outdoor advertisements (ads) within a portion of Accra, Ghana and (2) quantify the types of ads that appeared along the Accra-Cape Coast Highway. SETTING: A 4.7 km(2) area of Accra, Ghana and a 151 km region along the highway represented the target areas for collecting photos of outdoor beverage ads. PRIMARY AND SECONDARY OUTCOME MEASURES: Number and types of beverage ads, sugar content of beverage products featured in ads and marketing themes used in ads...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28575784/exposure-to-extremely-low-and-intermediate-frequency-magnetic-and-electric-fields-among-children-from-the-inma-gipuzkoa-cohort
#6
Mara Gallastegi, Ana Jiménez-Zabala, Loreto Santa-Marina, Juan J Aurrekoetxea, Mikel Ayerdi, Jesús Ibarluzea, Hans Kromhout, Julián González, Anke Huss
Detailed assessment of exposure to extremely low frequency (ELF) and intermediate frequency (IF) fields is essential in order to conduct informative epidemiological studies of the health effects from exposure to these fields. There is limited information available regarding ELF electric fields and on both magnetic and electric field exposures of children in the IF range. The aim of this study was to characterize ELF and IF exposure of children in the Spanish INMA cohort. A combination of spot and fixed measurements was carried out in 104 homes, 26 schools and their playgrounds and 105 parks...
August 2017: Environmental Research
https://www.readbyqxmd.com/read/28557736/change-of-school-playground-environment-on-bullying-a-randomized-controlled-trial
#7
Victoria L Farmer, Sheila M Williams, Jim I Mann, Grant Schofield, Julia C McPhee, Rachael W Taylor
OBJECTIVE: To investigate whether increasing risk and challenge in primary school playgrounds influences interactions between children. METHODS: In a 2-year cluster-randomized controlled trial, 8 control schools were asked to not change their play environment, whereas 8 intervention schools increased opportunities for risk and challenge (eg, rough-and-tumble play), reduced rules, and added loose parts (eg, tires). Children (n = 840), parents (n = 635), and teachers (n = 90) completed bullying questionnaires at baseline, 1 (postintervention), and 2 (follow-up) years...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28553741/use-of-two-test-methods-to-ensure-accurate-surface-firmness-and-stability-measurements-for-accessibility
#8
Peter W Axelson, Seanna L Hurley
PURPOSE: The firmness and stability of indoor and outdoor surfacing are critical to the accessibility and safety of all environments for people with mobility impairments and/or who use mobility devices. ASTM F1951 laboratory test procedures include pass/fail criteria for determining playground surface accessibility by comparing the work to propel up a 1:14 (7.1%) grade ramp to that of the test surface in a wheelchair. A portable instrumented surface indenter (ISI) was developed to validate that accessibility results obtained in the laboratory are maintained in the field where the surface is installed and used...
May 27, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28550943/microbiome-on-a-chip-new-frontiers-in-plant-microbiota-research
#9
Claire E Stanley, Marcel G A van der Heijden
An enigmatic concoction of interactions between microbes and hosts takes place below ground, yet the function(s) of the individual components in this complex playground are far from understood. This Forum article highlights how microfluidic - or 'Microbiome-on-a-Chip' - technology could help to shed light on such relationships, opening new frontiers in plant-microbiota research.
May 24, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28549470/rationale-and-protocol-paper-for-the-healthy-active-peaceful-playgrounds-for-youth-happy-study
#10
Wayne Cotton, Dean Dudley, Kirsten Jackson, Matthew Winslade, Janice Atkin
BACKGROUND: A growing body of evidence suggest an association between physical activity levels and students psychological well-being. A number of research studies have evaluated playground interventions that aim to increase physical activity levels, decrease conflict and bullying, and improve students behaviour. The HAPPY Study will evaluate the success of an intervention combining environmental modifications, teacher development, and peer support that can culminate in an easy to implement, low cost and effective model for increasing physical activity, and improving psychological well-being for children...
May 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28545900/environmental-contamination-with-toxocara-spp-eggs-in-public-parks-and-playground-sandpits-of-greater-lisbon-portugal
#11
David Otero, Ana Margarida Alho, Rolf Nijsse, Jeroen Roelfsema, Paul Overgaauw, Luís Madeira de Carvalho
Toxocarosis is a zoonotic parasitic disease transmitted from companion animals to humans. Environmental contamination with Toxocara eggs is considered to be the main source of human infections. In Portugal, knowledge regarding the current situation, including density, distribution and environmental contamination by Toxocara spp., is largely unknown. The present study investigated environmental contamination with Toxocara spp. eggs, in soil and faecal samples collected from public parks and playground sandpits in Greater Lisbon, Portugal...
May 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28526064/seasonal-variation-in-the-prevalence-of-toxocara-eggs-on-children-s-playgrounds-in-the-city-of-hanover-germany
#12
Annika Kleine, Andrea Springer, Christina Strube
BACKGROUND: Roundworms of the genus Toxocara are worldwide distributed zoonotic parasites of carnivores. Based on case numbers and the potential impact on human health, the Centers for Disease Control and Prevention (CDC) categorised toxocarosis as one of the most important neglected parasitic diseases. As contact with contaminated soil, e.g. in sandpits, is considered the primary transmission route, data on playground contamination are needed to assess infection risk for children. Here, playground contamination rates and their seasonal variation in the city of Hanover, Germany, were investigated...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28521596/overcoming-the-current-issues-surrounding-device-leads-reducing-the-complications-during-extraction
#13
Maria Grazia Bongiorni, Luca Segreti, Andrea Di Cori, Giulio Zucchelli, Luca Paperini, Stefano Viani, Ezio Soldati
The implantation rate of cardiac implantable electronic devices has consistently increased in the last 20 years, as have the related complication rates. The most relevant issue is the removal of pacing and implantable cardioverter defibrillator (ICD) leads, which a few months after implantation tend to develop intravascular fibrosis, often making extraction a challenging and risky procedure. Areas covered: The transvenous lead extraction (TLE) scenario is constantly evolving. TLE is a key procedure in lead management strategies...
June 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28511682/inequities-in-coverage-of-smokefree-space-policies-within-the-united-states
#14
Christopher Lowrie, Amber L Pearson, George Thomson
BACKGROUND: Previous studies have found extensive geographic and demographic differences in tobacco use. These differences have been found to be reduced by effective public policies, including banning smoking in public spaces. Smokefree indoor and outdoor spaces reduce secondhand smoke exposure and denormalize smoking. METHODS: We evaluated regional and demographic differences in the proportion of the population covered by smokefree policies enacted in the United States prior to 2014, for both adults and children...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28509887/predictors-of-segmented-school-day-physical-activity-and-sedentary-time-in-children-from-a-northwest-england-low-income-community
#15
Sarah L Taylor, Whitney B Curry, Zoe R Knowles, Robert J Noonan, Bronagh McGrane, Stuart J Fairclough
Schools have been identified as important settings for health promotion through physical activity participation, particularly as children are insufficiently active for health. The aim of this study was to investigate the child and school-level influences on children's physical activity levels and sedentary time during school hours in a sample of children from a low-income community; Methods: One hundred and eighty-six children (110 boys) aged 9-10 years wore accelerometers for 7 days, with 169 meeting the inclusion criteria of 16 h∙day(-1) for a minimum of three week days...
May 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28493060/synthetic-turf-fields-crumb-rubber-and-alleged-cancer-risk
#16
Archie Bleyer
Most synthetic turf fields have crumb rubber interspersed among the simulated grass fibers to reduce athletic injuries by allowing users to turn and slide more readily as they play sports or exercise on the fields. Recently, the crumbs have been implicated in causing cancer in adolescents and young adults who use the fields, particularly lymphoma and primarily in soccer goalkeepers. This concern has led to the initiation of large-scale studies by local and federal governments that are expected to take years to complete...
May 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28491197/traumatic-rupture-of-a-giant-congenital-splenic-cyst-presenting-as-peritonitis
#17
Alexander Tassopoulos, Melissa Wein, Annette Segura
Splenic cysts are uncommon, with large cysts and complications being rare. We describe a 6-year-old patient who initially presented 1 day after falling onto her abdomen at the playground with worsening abdominal pain and distention. An ultrasound of the abdomen demonstrated free abdominal fluid in all four quadrants. A subsequent contrast-enhanced computed tomography scan of the abdomen and pelvis was performed which showed a large splenic cyst with open communication to the peritoneal cavity. A congenital primary cyst was confirmed on pathology after partial splenectomy was performed...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28467459/gap-crossing-behavior-in-a-standardized-and-a-nonstandardized-jumping-stone-configuration
#18
Karlijn Sporrel, Simone R Caljouw, Rob Withagen
Over the last years, the omnipresent standardization of playgrounds-the distances between, for example, jumping stones tend to be equal-has been criticized by both scientists and architects. First, it has been argued that standardization fails to do justice to the variability in the children's action capabilities. Second, it might simplify play in that children repetitively cross over the same distance and, thus, do not have to worry about their movements anymore. In the present study we examined the gap-crossing behavior of children in both a standardized and a nonstandardized jumping stone configuration...
2017: PloS One
https://www.readbyqxmd.com/read/28467110/examining-sociodemographic-differences-in-playground-availability-and-quality-and-associations-with-childhood-obesity
#19
Shea M McCarthy, S Morgan Hughey, Andrew T Kaczynski
BACKGROUND: Parks and playgrounds are important environmental components for promoting healthy weight among children. The purposes of this study were to examine disparities in access to playgrounds and playground quality by multiple sociodemographic characteristics and the association of playground access and quality with youth weight status. METHODS: Objectively measured height and weight were collected for all third to fifth grade youth (n = 13,469) in a southeastern US County...
May 3, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28459527/molecular-dynamics-insights-into-water-parylene-c-interface-relevance-of-oxygen-plasma-treatment-for-biocompatibility
#20
Monika Golda-Cepa, Waldemar Kulig, Lukasz Cwiklik, Andrzej Kotarba
Solid-water interfaces play a vital role in biomaterials science because they provide a natural playground for most biochemical reactions and physiological processes. In the study, fully atomistic molecular dynamics simulations were performed to investigate interactions between water molecules and several surfaces modeling for unmodified and modified parylene C surfaces. The introduction of -OH, -CHO, and -COOH to the surface and alterations in their coverage significantly influence the energetics of interactions between water molecules and the polymer surface...
May 5, 2017: ACS Applied Materials & Interfaces
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