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https://www.readbyqxmd.com/read/27621439/breast-cancer-tumorigenicity-is-dependent-on-high-expression-levels-of-naf-1-and-the-lability-of-its-fe-s-clusters
#1
Merav Darash-Yahana, Yair Pozniak, Mingyang Lu, Yang-Sung Sohn, Ola Karmi, Sagi Tamir, Fang Bai, Luhua Song, Patricia A Jennings, Eli Pikarsky, Tamar Geiger, José N Onuchic, Ron Mittler, Rachel Nechushtai
Iron-sulfur (Fe-S) proteins are thought to play an important role in cancer cells mediating redox reactions, DNA replication, and telomere maintenance. Nutrient-deprivation autophagy factor-1 (NAF-1) is a 2Fe-2S protein associated with the progression of multiple cancer types. It is unique among Fe-S proteins because of its 3Cys-1His cluster coordination structure that allows it to be relatively stable, as well as to transfer its clusters to apo-acceptor proteins. Here, we report that overexpression of NAF-1 in xenograft breast cancer tumors results in a dramatic augmentation in tumor size and aggressiveness and that NAF-1 overexpression enhances the tolerance of cancer cells to oxidative stress...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27372764/crystallographic-studies-of-telomerase
#2
H Hoffman, E Skordalakes
Telomeres are nucleoprotein complexes that maintain the ends of our chromosomes thus providing genomic stability. Telomerase is a ribonucleoprotein reverse transcriptase that replicates the short tandem repeats of DNA known as telomeres. The telomeric DNA is specifically associated with two major complexes, the shelterin and CST complexes both of which are involved in telomere length regulation and maintenance along with telomerase. Obtaining structural information on these nucleoprotein complexes has been a major bottleneck in fully understanding the mechanism of action of telomeric nucleoproteins for over two decades...
2016: Methods in Enzymology
https://www.readbyqxmd.com/read/27312549/telomere-shortening-in-alzheimer-s-disease-patients
#3
Mengyuan Liu, Ya Ruth Huo, Junwei Wang, Change Wang, Shuling Liu, Shuai Liu, Jinhuan Wang, Yong Ji
BACKGROUND AND AIMS: Sporadic Alzheimer's Disease (AD) is considered an age-related disease, and telomere length has been shown to decrease with age in animal and human studies. Shortening of telomere length has also been reported to beis associated with numerous neurodegenerative diseases, including AD. The aim of this study is to confirm and further elucidate the relationship between peripheral telomere length and Alzheimer's disease, cognitive function, and duration of Alzheimer's disease...
May 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/26674112/leukocyte-telomere-length-and-hippocampus-volume-a-meta-analysis
#4
Gustav Nilsonne, Sandra Tamm, Kristoffer N T Månsson, Torbjörn Åkerstedt, Mats Lekander
Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0...
2015: F1000Research
https://www.readbyqxmd.com/read/26476632/food-supplementation-with-rice-bran-enzymatic-extract-prevents-vascular-apoptosis-and-atherogenesis-in-apoe-mice
#5
C Perez-Ternero, M D Herrera, U Laufs, M Alvarez de Sotomayor, C Werner
PURPOSE: Atherosclerosis is associated with reduced mononuclear cell (MNC) telomere length, and senescent cells have been detected in atherosclerotic plaques. Rice bran is a source of γ-oryzanol, phytosterols and tocols with potential lipid-lowering, antioxidant and anti-inflammatory activities. Here, we tested the hypothesis that rice bran enzymatic extract (RBEE) impacts on apoptosis, telomere length and atherogenesis in mice. METHODS: Seven-week-old male ApoE-/- mice were fed high-fat diet (HFD) or isocaloric HFD supplemented with 5 % (w/w) RBEE for 23 weeks...
October 17, 2015: European Journal of Nutrition
https://www.readbyqxmd.com/read/26416809/vascular-smooth-muscle-cell-senescence-promotes-atherosclerosis-and-features-of-plaque-vulnerability
#6
Julie Wang, Anna K Uryga, Johannes Reinhold, Nichola Figg, Lauren Baker, Alison Finigan, Kelly Gray, Sheetal Kumar, Murray Clarke, Martin Bennett
BACKGROUND: Although vascular smooth muscle cell (VSMC) proliferation is implicated in atherogenesis, VSMCs in advanced plaques and cultured from plaques show evidence of VSMC senescence and DNA damage. In particular, plaque VSMCs show shortening of telomeres, which can directly induce senescence. Senescence can have multiple effects on plaque development and morphology; however, the consequences of VSMC senescence or the mechanisms underlying VSMC senescence in atherosclerosis are mostly unknown...
November 17, 2015: Circulation
https://www.readbyqxmd.com/read/26363462/calorimetric-and-spectroscopic-investigations-of-the-binding-of-metallated-porphyrins-to-g-quadruplex-dna
#7
Jesse I DuPont, Kate L Henderson, Amanda Metz, Vu H Le, Joseph P Emerson, Edwin A Lewis
BACKGROUND: The human telomere contains tandem repeat of (TTAGG) capable of forming a higher order DNA structure known as G-quadruplex. Porphyrin molecules such as TMPyP4 bind and stabilize G-quadruplex structure. METHODS: Isothermal titration calorimetry (ITC), circular dichroism (CD), and mass spectroscopy (ESI/MS), were used to investigate the interactions between TMPyP4 and the Co(III), Ni(II), Cu(II), and Zn(II) complexes of TMPyP4 (e.g. Co(III)-TMPyP4) and a model human telomere G-quadruplex (hTel22) at or near physiologic ionic strength ([Na(+)] or [K(+)]≈0...
May 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26004735/aging-of-intrauterine-tissues-in-spontaneous-preterm-birth-and-preterm-premature-rupture-of-the-membranes-a-systematic-review-of-the-literature
#8
REVIEW
J Polettini, E H Dutta, F Behnia, G R Saade, M R Torloni, R Menon
BACKGROUND: Many adverse pregnancy outcomes (APOs), including spontaneous preterm birth (PTB), are associated with placental dysfunction. Recent clinical and experimental evidences suggest that premature aging of the placenta may be involved in these events. Although placental aging is a well-known concept, the mechanisms of aging during normal pregnancy and premature aging in APOs are still unclear. This review was conducted to assess the knowledge on placental aging related biochemical changes leading to placental dysfunction in PTB and/or preterm premature rupture of membranes (pPROM)...
September 2015: Placenta
https://www.readbyqxmd.com/read/25609760/development-and-validation-of-risk-index-for-cognitive-decline-using-blood-derived-markers
#9
Jasmine Nettiksimmons, Hilsa Ayonayon, Tamara Harris, Caroline Phillips, Caterina Rosano, Suzanne Satterfield, Kristine Yaffe
OBJECTIVE: We sought to develop and validate a risk index for prospective cognitive decline in older adults based on blood-derived markers. METHODS: The index was based on 8 markers that have been previously associated with cognitive aging: APOE genotype, plasma β-amyloid 42/40 ratio, telomere length, cystatin C, glucose, C-reactive protein, interleukin-6, and albumin. The outcome was person-specific cognitive slopes (Modified Mini-Mental State Examination) from 11 years of follow-up...
February 17, 2015: Neurology
https://www.readbyqxmd.com/read/25452402/telomerase-gene-htert-and-survival-results-from-two-swedish-cohorts-of-older-adults
#10
Grégoria Kalpouzos, Debora Rizzuto, Lina Keller, Johan Fastbom, Giola Santoni, Sara Angleman, Caroline Graff, Lars Bäckman, Laura Fratiglioni
Telomere length has been associated with longevity. As telomere length is partly determined by the human telomerase reverse transcriptase (hTERT), we investigated the association between an hTERT polymorphism located in its promoter region ((-) (1327)T/C) and longevity in two cohorts of older adults. Participants from the Kungsholmen project (KP; n = 1,205) and the Swedish National study of Aging and Care in Kungsholmen (SNAC-K; n = 2,764) were followed for an average period of 7.5 years. The main outcomes were hazard ratios (HR) of mortality and median age at death...
February 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/25090243/effect-of-leukocyte-telomere-length-on-total-and-regional-brain-volumes-in-a-large-population-based-cohort
#11
Kevin S King, Julia Kozlitina, Roger N Rosenberg, Ronald M Peshock, Roderick W McColl, Christine K Garcia
IMPORTANCE: Telomere length has been associated with dementia and psychological stress, but its relationship with human brain size is unknown. OBJECTIVE: To determine if peripheral blood telomere length is associated with brain volume. DESIGN, SETTING, AND PARTICIPANTS: Peripheral blood leukocyte telomere length and brain volumes were measured for 1960 individuals in the Dallas Heart Study, a population-based, probability sample of Dallas County, Texas, residents, with a median (25th-75th percentile) age of 50 (42-58) years...
October 2014: JAMA Neurology
https://www.readbyqxmd.com/read/24470519/hypercholesterolemia-induces-oxidant-stress-that-accelerates-the-ageing-of-hematopoietic-stem-cells
#12
Guodong Tie, Katharine E Messina, Jinglian Yan, Julia A Messina, Louis M Messina
BACKGROUND: Clinical studies suggest that hypercholesterolemia may cause ageing in hematopoietic stem cells (HSCs) because ageing-associated alterations were found in peripheral blood cells and their bone marrow residing precursors in patients with advanced atherosclerosis. We hypothesized that hypercholesterolemia induces oxidant stress in hematopoietic stems cells that accelerates their ageing. METHODS AND RESULTS: Here we show that HSCs from ApoE(-/-) mice, as well as HSCs from C57Bl/6 mice fed a high cholesterol diet (HCD) accumulated oxLDL and had greater ROS levels...
2014: Journal of the American Heart Association
https://www.readbyqxmd.com/read/23418430/accelerated-cell-aging-in-female-apoe-%C3%AE%C2%B54-carriers-implications-for-hormone-therapy-use
#13
RANDOMIZED CONTROLLED TRIAL
Emily G Jacobs, Candyce Kroenke, Jue Lin, Elissa S Epel, Heather A Kenna, Elizabeth H Blackburn, Natalie L Rasgon
Apolipoprotein-ε4 (APOE-ε4) is a major genetic risk factor for cognitive decline, Alzheimer's disease (AD) and early mortality. An accelerated rate of biological aging could contribute to this increased risk. Here, we determined whether APOE-ε4 status impacts leukocyte telomere length (TL) and the rate of cellular senescence in healthy mid-life women and, further, whether hormone replacement therapy (HT) modifies this association. Post-menopausal women (N = 63, Mean age = 57.7), all HT users for at least one year, were enrolled in a randomized longitudinal study...
2013: PloS One
https://www.readbyqxmd.com/read/22506016/longer-leukocyte-telomere-length-is-associated-with-smaller-hippocampal-volume-among-non-demented-apoe-%C3%AE%C2%B53-%C3%AE%C2%B53-subjects
#14
Mikael Wikgren, Thomas Karlsson, Johanna Lind, Therese Nilbrink, Johan Hultdin, Kristel Sleegers, Christine Van Broeckhoven, Göran Roos, Lars-Göran Nilsson, Lars Nyberg, Rolf Adolfsson, Karl-Fredrik Norrback
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr...
2012: PloS One
https://www.readbyqxmd.com/read/22016362/association-between-apoe-phenotypes-and-telomere-erosion-in-alzheimer-s-disease
#15
Yusuke Takata, Masayuki Kikukawa, Haruo Hanyu, Shunichi Koyama, Soichiro Shimizu, Takahiko Umahara, Hirofumi Sakurai, Toshihiko Iwamoto, Kazuma Ohyashiki, Junko H Ohyashiki
Although several reports suggest that Alzheimer's disease (AD) is associated with shortened telomere length, the clinical relevance of this has not yet been fully elucidated. This study was conducted to clarify the correlation of telomere length with clinical characteristics and ApoE phenotypes in 74 AD patients. Telomere length was determined from genomic DNA extracted from whole blood by quantitative real-time polymerase chain reaction. We found no significant difference in telomere length between the AD and non-dementia elderly control (n = 35) groups...
April 2012: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/20709332/telomere-length-and-apoe-polymorphism-in-mild-cognitive-impairment-degenerative-and-vascular-dementia
#16
Dina Zekry, François R Herrmann, Irmgard Irminger-Finger, Cristophe Graf, Chantal Genet, Anna-Maria Vitale, Jean-Pierre Michel, Gabriel Gold, Karl-Heinz Krause
BACKGROUND: Clarifying the aetiology of dementia is of crucial importance in the management of patients as well as for research purposes but it is not always possible clinically. Therefore the identification of biological markers should complement clinical approaches. Telomere shortening is emerging as an important mechanism in vascular aging and the pathogenesis of hypertension and atherosclerosis. Thus, telomere length could be a potential candidate to accurately separate vascular from degenerative cognitive impairment...
December 15, 2010: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/20608977/linking-pseudouridine-synthases-to-growth-development-and-cell-competition
#17
Giuseppe Tortoriello, José F de Celis, Maria Furia
Eukaryotic pseudouridine synthases direct RNA pseudouridylation and bind H/ACA small nucleolar RNA (snoRNAs), which, in turn, may act as precursors of microRNA-like molecules. In humans, loss of pseudouridine synthase activity causes dyskeratosis congenita (DC), a complex systemic disorder characterized by cancer susceptibility, failures in ribosome biogenesis and telomere stability, and defects in stem cell formation. Considering the significant interest in deciphering the various molecular consequences of pseudouridine synthase failure, we performed a loss of function analysis of minifly (mfl), the pseudouridine synthase gene of Drosophila, in the wing disc, an advantageous model system for studies of cell growth and differentiation...
August 2010: FEBS Journal
https://www.readbyqxmd.com/read/20395015/apoe-%C3%AE%C2%B54-is-associated-with-longer-telomeres-and-longer-telomeres-among-%C3%AE%C2%B54-carriers-predicts-worse-episodic-memory
#18
Mikael Wikgren, Thomas Karlsson, Therese Nilbrink, Katarina Nordfjäll, Johan Hultdin, Kristel Sleegers, Christine Van Broeckhoven, Lars Nyberg, Göran Roos, Lars-Göran Nilsson, Rolf Adolfsson, Karl-Fredrik Norrback
Both leukocyte telomere length and the apolipoprotein ε4 allele have been associated with mortality, cardiovascular disease, cognition, and dementia. The authors investigated whether leukocyte telomere length was associated with APOE genotype or cognitive abilities in the context of APOE genotype. The setting for this cross-sectional study was 427 nondemented individuals aged 41-81 yr. The authors found that ε4 carriers overall exhibited significantly longer telomeres compared with non-carriers (difference of 268 bp, p = 0...
February 2012: Neurobiology of Aging
https://www.readbyqxmd.com/read/17417064/genetic-pathway-of-major-depressive-disorder-in-shortening-telomeric-length
#19
For-Wey Lung, Nathan C Chen, Bih-Ching Shu
CONTEXT: Shortened telomeric length has been associated with aging and monoamine oxidase A gene activity. The pathways of genetic activity and mental disorder in shortening telomeric length, however, remain unclear. OBJECTIVE: The purpose of this study was to explore the possible pathways of the monoamine oxidase A promoter, ApoE polymorphisms and telomeric length in major depressive disorder. METHODS: This study enrolled 253 unrelated patients with major depression in southern Taiwan, and was carried out between March 2001 and September 2004...
June 2007: Psychiatric Genetics
https://www.readbyqxmd.com/read/16807921/shorter-telomeres-are-associated-with-mortality-in-those-with-apoe-epsilon4-and-dementia
#20
Lawrence S Honig, Nicole Schupf, Joseph H Lee, Ming X Tang, Richard Mayeux
OBJECTIVE: Reduced telomere length may be a marker of biological aging. We hypothesized that telomere length might thus relate to increased risk for dementia and mortality. METHODS: This nested case-control study used stored leukocyte DNA from 257 individuals (mean age, 81.4 +/- 7.9 years; 64.6% female; 44.7% Hispanic, 33.5% non-Hispanic black, and 21.8% non-Hispanic white). Our assay used real-time polymerase chain reaction, with two separate reactions amplifying telomere sequence and reference single copy gene (ribosomal-protein-P0), providing a calculated telomere-to-single copy gene (T/S) ratio...
August 2006: Annals of Neurology
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