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https://www.readbyqxmd.com/read/29143594/the-gene-smart-study-method-study-design-and-preliminary-findings
#1
REVIEW
Xu Yan, Nir Eynon, Ioannis D Papadimitriou, Jujiao Kuang, Fiona Munson, Oren Tirosh, Lannie O'Keefe, Lyn R Griffiths, Kevin J Ashton, Nuala Byrne, Yannis P Pitsiladis, David J Bishop
The gene SMART (genes and the Skeletal Muscle Adaptive Response to Training) Study aims to identify genetic variants that predict the response to both a single session of High-Intensity Interval Exercise (HIIE) and to four weeks of High-Intensity Interval Training (HIIT). While the training and testing centre is located at Victoria University, Melbourne, three other centres have been launched at Bond University, Queensland University of Technology, Australia, and the University of Brighton, UK. Currently 39 participants have already completed the study and the overall aim is to recruit 200 moderately-trained, healthy Caucasians participants (all males 18-45 y, BMI < 30)...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29140910/polygenic-profile-and-exercise-induced-muscle-damage-by-a-competitive-half-ironman
#2
Juan Del Coso, Juan J Salinero, Beatriz Lara, César Gallo-Salazar, Francisco Areces, David Herrero, Carlos Puente
Del Coso, J, Salinero, JJ, Lara, B, Gallo-Salazar, C, Areces, F, Herrero, D, and Puente, C. Polygenic profile and exercise-induced muscle damage by a competitive half-ironman. J Strength Cond Res XX(X): 000-000, 2017-To date, it is still unknown why some individuals develop higher levels of muscle damage than other individuals, despite participating in exercise with comparable levels of physical intensity. The aim of this investigation was to analyze 7 single-nucleotide polymorphisms (SNPs) that are candidates to explain individual variations in the level of muscle damage attained during a half-ironman competition...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140352/extended-ellipticity-control-for-attosecond-pulses-by-high-harmonic-generation
#3
Nickolai Zhavoronkov, Mikhail Ivanov
Attosecond (1  as=10(-18)  s) pulses produced through high harmonic generation (HHG) are a basis for studies of electron dynamics during light-matter interaction on an electron's natural time scale. Extensively exploited HHG technology has, however, a few unsolved problems, where producing of circularly polarized or chiral attosecond pulses belongs to them. We have demonstrated experimentally a way to control the ellipticity of attosecond pulse trains produced via HHG in two-color, bi-circular laser fields...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140147/sprint-running-performance-and-technique-changes-in-athletes-during-periodized-training-an-elite-training-group-case-study
#4
Ian N Bezodis, David G Kerwin, Stephen-Mark Cooper, Aki I T Salo
PURPOSE: To understand how training periodization influences sprint performance and key step characteristics over an extended training period in an elite sprint training group. METHODS: Four sprinters were studied during five months of training. Step velocities, step lengths and step frequencies were measured from video of the maximum velocity phase of training sprints. Bootstrapped mean values were calculated for each athlete for each session and 139 within-athlete, between-session comparisons were made with a repeated measures ANOVA...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29139007/adding-high-intensity-interval-training-to-conventional-training-modalities-optimizing-health-related-outcomes-during-chemotherapy-for-breast-cancer-the-optitrain-randomized-controlled-trial
#5
Sara Mijwel, Malin Backman, Kate A Bolam, Anna Jervaeus, Carl Johan Sundberg, Sara Margolin, Maria Browall, Helene Rundqvist, Yvonne Wengström
PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy...
November 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29135641/the-pediatric-endurance-athlete
#6
Mary L Solomon, Susannah M Briskin, Nicole Sabatina, Jennifer E Steinhoff
Youth sports participation numbers continue to grow in the United States. A shift toward sport specialization has caused an increase in sport training frequency and intensity that places the growing athlete at risk for overtraining, nutritional deficits, and injuries. Individuals who participate in endurance sports are at especially high risk. Youth runners and swimmers are high-risk populations that require special attention to their training schedules, nutritional intake, and injuries. Appropriate scheduling of training, dedicating time to rest, and nutrition education can help prevent problems in the endurance athlete...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29133320/effect-of-an-intensive-3-week-preoperative-home-rehabilitation-programme-in-patients-with-chronic-obstructive-pulmonary-disease-eligible-for-lung-cancer-surgery-a-multicentre-randomised-controlled-trial
#7
Hélène Laurent, Géraud Galvaing, Emilie Thivat, Emmanuel Coudeyre, Sylvie Aubreton, Ruddy Richard, Fabrice Kwiatkowski, Frederic Costes, Marc Filaire
INTRODUCTION: Surgery is the standard curative treatment for lung cancer but is only possible in patients with local tumour and preserved exercise capacity. Improving fitness before surgery can reduce postoperative complications and mortality. However, preoperative rehabilitation remains difficult to implement for several reasons. We aim to investigate the effectiveness of an intensive 3-week home-based preoperative exercise training programme on hospital discharge ability, postoperative complications and physical performance in patients with chronic obstructive pulmonary disease (COPD) who are eligible for lung cancer surgery...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133220/effects-of-exercise-and-diet-in-nonobese-asthma-patients-a-randomized-controlled-trial
#8
Louise Lindhardt Toennesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjoern Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer
BACKGROUND: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. OBJECTIVES: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29129740/survey-on-neonatal-end-of-life-comfort-care-guidelines-across-america
#9
Shelly Haug, Sara Farooqi, Christopher G Wilson, Andrew Hopper, Grace Oei, Brian Carter
CONTEXT: Infants of age < 1 year have the highest mortality rate in pediatrics. The American Academy of Pediatrics (AAP) published guidelines for palliative care in 2013, however, significant variation persists among local protocols addressing neonatal comfort care at the end-of-life (EOL). OBJECTIVES: The purpose of this study was to evaluate current neonatal EOL comfort care practices and clinician satisfaction across America METHODS: After Institutional Review Board approval (516005), an anonymous, electronic survey was sent to members of the AAP Section on Neonatal-Perinatal Medicine...
November 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29129021/the-effect-of-natural-or-simulated-altitude-training-on-high-intensity-intermittent-running-performance-in-team-sport-athletes-a-meta-analysis
#10
REVIEW
Michael J Hamlin, Catherine A Lizamore, Will G Hopkins
BACKGROUND: While adaptation to hypoxia at natural or simulated altitude has long been used with endurance athletes, it has only recently gained popularity for team-sport athletes. OBJECTIVE: To analyse the effect of hypoxic interventions on high-intensity intermittent running performance in team-sport athletes. METHODS: A systematic literature search of five journal databases was performed. Percent change in performance (distance covered) in the Yo-Yo intermittent recovery test (level 1 and level 2 were used without differentiation) in hypoxic (natural or simulated altitude) and control (sea level or normoxic placebo) groups was meta-analyzed with a mixed model...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29127602/effect-of-high-intensity-interval-training-on-total-abdominal-and-visceral-fat-mass-a-meta-analysis
#11
REVIEW
Florie Maillard, Bruno Pereira, Nathalie Boisseau
BACKGROUND: High-intensity interval training (HIIT) is promoted as a time-efficient strategy to improve body composition. OBJECTIVE: The aim of this meta-analysis was to assess the efficacy of HIIT in reducing total, abdominal, and visceral fat mass in normal-weight and overweight/obese adults. METHODS: Electronic databases were searched to identify all related articles on HIIT and fat mass. Stratified analysis was performed using the nature of HIIT (cycling versus running, target intensity), sex and/or body weight, and the methods of measuring body composition...
November 10, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29126253/enabling-phenotypic-big-data-with-phenorm
#12
Sheng Yu, Yumeng Ma, Jessica Gronsbell, Tianrun Cai, Ashwin N Ananthakrishnan, Vivian S Gainer, Susanne E Churchill, Peter Szolovits, Shawn N Murphy, Isaac S Kohane, Katherine P Liao, Tianxi Cai
Objective: Electronic health record (EHR)-based phenotyping infers whether a patient has a disease based on the information in his or her EHR. A human-annotated training set with gold-standard disease status labels is usually required to build an algorithm for phenotyping based on a set of predictive features. The time intensiveness of annotation and feature curation severely limits the ability to achieve high-throughput phenotyping. While previous studies have successfully automated feature curation, annotation remains a major bottleneck...
November 3, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29125029/match-derived-relative-pitch-area-changes-the-physical-and-team-tactical-performance-of-elite-soccer-players-in-small-sided-soccer-games
#13
Sigrid B H Olthof, Wouter G P Frencken, Koen A P M Lemmink
Small-sided games (SSGs) are used in training sessions to prepare for full-sized matches. For the same number of players, smaller pitch sizes result in decreased physical performance and shorter interpersonal distances. A relative pitch area derived from the full-sized match results in larger pitch sizes and this may increase the fit between SSGs and full-sized matches. This study aimed to investigate SSGs with a traditional small pitch and a match-derived relative pitch area in youth elite soccer players. Four age categories (under-13, under-15, under-17 and under-19) played 4 vs...
November 10, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29124506/heart-rate-variability-biofeedback-does-not-substitute-for-asthma-steroid-controller-medication
#14
Paul M Lehrer, Charles G Irvin, Shou-En Lu, Anthony Scardella, Beatrix Roehmheld-Hamm, Milisyaris Aviles-Velez, Jessica Graves, Evgeny G Vaschillo, Bronya Vaschillo, Flavia Hoyte, Harold Nelson, Frederick S Wamboldt
Despite previous findings of therapeutic effects for heart rate variability biofeedback (HRVB) on asthma, it is not known whether HRVB can substitute either for controller or rescue medication, or whether it affects airway inflammation. Sixty-eight paid volunteer steroid naïve study participants with mild or moderate asthma were given 3 months of HRVB or a comparison condition consisting of EEG alpha biofeedback with relaxing music and relaxed paced breathing (EEG+), in a two-center trial. All participants received a month of intensive asthma education prior to randomization...
November 9, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/29124453/a-machine-learning-ensemble-classifier-for-early-prediction-of-diabetic-retinopathy
#15
Somasundaram S K, Alli P
The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed...
November 9, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29124370/popular-weight-loss-strategies-a-review-of-four-weight-loss-techniques
#16
REVIEW
Jonathan Obert, Michelle Pearlman, Lois Obert, Sarah Chapin
PURPOSE OF REVIEW: The purpose of this paper is to review the epidemiology of obesity and the most recent literature on popular fad diets and exercise regimens that are used for weight loss. The weight loss plans that will be discussed in this article include juicing or detoxification diets, intermittent fasting, the paleo diet, and high intensity training. RECENT FINDINGS: Despite the growing popularity of fad diets and exercise plans for weight loss, there are limited studies that actually suggest these particular regimens are beneficial and lead to long-term weight loss...
November 9, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29124325/changes-in-fat-oxidation-in-response-to-various-regimes-of-high-intensity-interval-training-hiit
#17
REVIEW
Todd Anthony Astorino, Matthew M Schubert
Increased whole-body fat oxidation (FOx) has been consistently demonstrated in response to moderate intensity continuous exercise training. Completion of high intensity interval training (HIIT) and its more intense form, sprint interval training (SIT), has also been reported to increase FOx in different populations. An explanation for this increase in FOx is primarily peripheral adaptations via improvements in mitochondrial content and function. However, studies examining changes in FOx are less common in response to HIIT or SIT than those determining increases in maximal oxygen uptake which is concerning, considering that FOx has been identified as a predictor of weight gain and glycemic control...
November 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29124115/study-protocol-of-the-intense-physical-activity-and-cognition-study-the-effect-of-high-intensity-exercise-training-on-cognitive-function-in-older-adults
#18
Belinda M Brown, Stephanie R Rainey-Smith, Natalie Castalanelli, Nicole Gordon, Shaun Markovic, Hamid R Sohrabi, Michael Weinborn, Simon M Laws, James Doecke, Kaikai Shen, Ralph N Martins, Jeremiah J Peiffer
Introduction: Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6-month high-intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6-month moderate-intensity exercise intervention and control group (no study-related exercise)...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29123559/factors-associated-with-success-in-the-oral-part-of-the-european-diploma-in-intensive-care
#19
Petr Waldauf, Francesca Rubulotta, Christian Sitzwohl, Paul Elbers, Armand Girbes, Rajnish Saha, Brian Marsh, Ravindra Kumar, Marco Maggiorini, František Duška
Introduction: The oral part of European Diploma in Intensive Care diploma examinations changed in 2013 into an objective structured clinical examination-type exam. This step was undertaken to provide a fair and reproducible clinical exam. All candidates face identical questions with predefined correct answers simultaneously in seven high throughput exam centres on the same day. We describe the factors that are associated with success in part 2 European Diploma in Intensive Care exam. Methods: We prospectively collected self-reported data from all candidates sitting European Diploma in Intensive Care part 2 in 2015, namely demographics, professional background and attendance to a European Diploma in Intensive Care part 2 or generic objective structured clinical examination preparatory courses...
November 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29123485/intensifying-functional-task-practice-to-meet-aerobic-training-guidelines-in-stroke-survivors
#20
Liam P Kelly, Augustine J Devasahayam, Arthur R Chaves, Elizabeth M Wallack, Jason McCarthy, Fabien A Basset, Michelle Ploughman
Objective: To determine whether stroke survivors could maintain workloads during functional task practice that can reach moderate levels of cardiometabolic stress (i.e., ≥40% oxygen uptake reserve ([Formula: see text]O2R) for ≥20 min) without the use of ergometer-based exercise. Design: Cross-sectional study using convenience sampling. Setting: Research laboratory in a tertiary rehabilitation hospital. Participants: Chronic hemiparetic stroke survivors (>6-months) who could provide consent and walk with or without assistance...
2017: Frontiers in Physiology
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