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https://www.readbyqxmd.com/read/28921741/chalcogen-atom-annulated-perylene-diimide-trimers-for-highly-efficient-nonfullerene-polymer-solar-cells
#1
Yuwei Duan, Xiaopeng Xu, Ying Li, Zuojia Li, Qiang Peng
This communication reports the synthesis of two novel chalcogen-atom-annulated perylene diimide (PDI) trimers with twisted structures, TriPDI-S and TriPDI-Se, for efficient nonfullerene polymer solar cells. TriPDI-Se exhibits more compact molecular arrangement due to the stronger intermolecular interactions induced by the selenium atom. This selenium annulation endows TriPDI-Se with improved absorption and crystallinity in its blend film. The resulting devices exhibit enhanced Jsc of 17.15 mA cm(-2) and fill factor (FF) of 66...
September 15, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28921450/nutrients-other-than-selenium-are-important-for-promoting-children-s-health-in-kashin-beck-disease-areas
#2
Yujie Ning, Xi Wang, Xiong Guo, Pan Zhang, Pengfei Qu, Feng Zhang, Sen Wang, Yanxia Lei, Mikko Lammi
Overall nutritional status has been proved associated with people's health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sectional study with three 24-h dietary recalls was conducted to collect raw data on the daily food intake of children. Recorded food was converted into daily nutrient intakes using CDGSS 3.0 software...
September 18, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28920824/baseline-health-and-nutrition-evaluation-of-two-sympatric-nocturnal-lemur-species-avahi-laniger-and-lepilemur-mustelinus-residing-near-an-active-mine-site-at-ambatovy-madagascar
#3
Randall E Junge, Cathy V Williams, Hajanirina Rakotondrainibe, Karine L Mahefarisoa, Tsiky Rajaonarivelo, Charles Faulkner, Vanessa Mass
Extractive industries can have significant impacts on ecosystems through loss of habitat, degradation of water quality, and direct impact on floral and faunal biodiversity. When operations are located in sensitive regions with high biodiversity containing endangered or threatened species, it is possible to minimize impact on the environment by developing programs to scientifically monitor the impact on resident flora and fauna species in the early phases of operation so that effects can be mitigated whenever possible...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28920049/effect-of-selenium-on-stress-response-in-coronary-artery-bypass-graft-surgery-a-clinical-trial
#4
Ali Mirmansouri, Vali Imantalab, Ali Mohammadzadeh Jouryabi, Gholamreza Kanani, Bahram Naderi Nabi, Farnoush Farzi, Gelareh Biazar, Samaneh Ghazanfar Tehran, Masoud Tarbiat
BACKGROUND: In spite of significant improvements in surgical and anesthetic techniques, acute stress response to surgery remains a main cause of mortality and morbidity in coronary artery bypass graft (CABG) surgery patients. Therefore, doing research to find safe and effective modalities with more cardio protective properties seems necessary. OBJECTIVES: In this study, we sought to determine whether intravenous injection of 600 μg Selenium (Se) prior to surgery would limit stress response measured by blood sugar...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28917711/crocodiles-and-alligators-antiamoebic-and-antitumor-compounds-of-crocodiles
#5
Ruqaiyyah Siddiqui, Shareni Jeyamogan, Salwa Mansoor Ali, Fatima Abbas, K A Sagathevan, Naveed Ahmed Khan
Crocodiles exist in unsanitary environments, feed on rotten meat, are often exposed to heavy metals such as arsenic, cadmium, cobalt, chromium, mercury, nickel, lead, selenium, tolerate high levels of radiation, and are amid the very few species to survive the catastrophic Cretaceous-Tertiary extinction event, nonetheless they can live for up to a 100 years. Moreover, as they live in unhygienic conditions, they regularly come across pathogens. Logically, we postulate that crocodiles have established mechanisms to defend themselves from noxious agents as well as protecting themselves from pathogens...
September 13, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28917054/association-of-single-nucleotide-polymorphisms-in-selenoprotein-genes-with-cancer-risk
#6
Catherine Méplan
Genetic association studies have linked genetic variants in the Selenium (Se) metabolism with the development of complex diseases such as cancer and helped unravel novel mechanisms underlying cancer development. The chapter describes the specificity of genetic variants in the Se metabolism, the approaches used in association studies, and the limitations of such approaches.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917052/monitoring-of-methionine-sulfoxide-content-and-methionine-sulfoxide-reductase-activity
#7
Lionel Tarrago, Emmanuel Oheix, Zalán Péterfi, Vadim N Gladyshev
The sulfur-containing amino acid methionine (Met) plays critical roles in protein synthesis, methylation, and sulfur metabolism. Both in its free form and in the form of an amino acid residue, it can be oxidized to the R and S diastereomers of methionine sulfoxide (MetO). Organisms evolved methionine sulfoxide reductases (MSRs) to reduce MetO to Met, with the MSRs type A (MSRA) and type B (MSRB) being specific for the S and R forms of MetO, respectively. In mammals, the selenoprotein MSRB1 plays an important protein repair function, and its expression is tightly regulated by dietary selenium...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917048/imaging-of-selenium-by-laser-ablation-inductively-coupled-plasma-mass-spectrometry-la-icp-ms-in-2-d-electrophoresis-gels-and-biological-tissues
#8
Elisa Castañeda Santa Cruz, J Susanne Becker, J Sabine Becker, Alessandra Sussulini
Selenium and selenoproteins are important components of living organisms that play a role in different biological processes. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a powerful analytical technique that has been employed to obtain distribution maps of selenium in biological tissues in a direct manner, as well as in selenoproteins, previously separated by their molecular masses and isoelectric points using two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). In this chapter, we present the protocols to perform LA-ICP-MS imaging experiments, allowing the distribution visualization and determination of selenium and/or selenoproteins in biological systems...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917047/detection-of-selenoproteins-by-laser-ablation-inductively-coupled-plasma-mass-spectrometry-la-icp-ms-in-immobilized-ph-gradient-ipg-strips
#9
Jordan Sonet, Sandra Mounicou, Laurent Chavatte
In contrast to other trace elements that are cofactors of enzymes and removed from proteins under denaturing conditions, Se is covalently bound to proteins when incorporated into selenoproteins, since it is a component of selenocysteine aminoacid. It implies that selenoproteins can undergo several biochemical separation methods in stringent and chaotropic conditions and still maintain the presence of selenium in the primary sequence. This feature has been used to develop a method for the detection of trace levels of human selenoproteins in cell extracts without the use of radioactive isotopes...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917046/nonradioactive-isotopic-labeling-and-tracing-of-selenoproteins-in-cultured-cell-lines
#10
Jordan Sonet, Sandra Mounicou, Laurent Chavatte
Selenium (Se) is an essential component of genetically encoded selenoproteins, in the form of a rare amino acid, namely the selenocysteine (Sec). Radioactive (75)Se has been widely used to trace selenoproteins in vitro and in vivo (cell models and animals). Alternatively, its unique isotopic pattern can be used to detect and characterize nonradioactive Se-compounds in cellular extracts using molecular or elemental mass spectrometry at ppm levels. However, when studying trace levels of Se-compounds, such as selenoproteins (ppt levels), the distribution of the signal between its six naturally abundant isotopes reduces its sensitivity...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917045/radioactive-75-se-labeling-and-detection-of-selenoproteins
#11
Sun Hee Yim, Ryuta Tobe, Anton A Turanov, Bradley A Carlson
The trace element selenium (Se) is incorporated into proteins as the amino acid selenocysteine (Sec), which is cotranslationally inserted into specific proteins in response to a UGA codon. Proteins containing Sec at these specific positions are called selenoproteins. Most selenoproteins function as oxidoreductases, while some serve other important functions. There are 25 known selenoprotein genes in humans and 24 in mice. The use of Sec allows selenoproteins to be detected by a convenient method involving metabolic labeling with (75)Se...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917044/simultaneous-speciation-of-selenoproteins-and-selenometabolites-in-plasma-and-serum
#12
Belén Callejón-Leblic, Gema Rodríguez-Moro, Tamara García-Barrera, José Luis Gómez-Ariza
Selenium is an essential element incorporated to different proteins with important biological functions in connection to antioxidant activity, cancer-protective properties, neurodegenerative pathologies, and prevention of effects of diabetes, among others. In addition, selenoamino acids play a basic role in the global equilibrium of key selenium-biomolecules synthesis, including selenoprotein P, selenoalbumin, and glutathione peroxidase. Homeostasis of these selenium-containing biomolecules involves different organs in living organisms including human, and bloodstream is the connection fluid in this process...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917043/quantification-of-semet-and-secys-in-biological-fluids-and-tissues-by-liquid-chromatography-coupled-to-inductively-coupled-plasma-mass-spectrometry-hplc-icp-ms
#13
Véronique Vacchina, Katarzyna Bierla, Joanna Szpunar, Ryszard Lobinski
Selenium (Se) is an element readily absorbed during the intestinal tract and distributed in the body. In biological fluids, tissues, and animal products, Se is known to be present mainly in the form of a selenoamino-acid (selenomethionine (SeMet) or selenocysteine (SeCys)). Both amino-acids have different biological activities which justifies their discrimination. Here, we describe the method allowing the simultaneous determination of SeMet and SeCys in blood/plasma, animal tissues, milk, and eggs by two-dimensional Liquid Chromatography coupled to Inductively Coupled Plasma Mass Spectrometry (2D HPLC-ICP MS)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917042/total-selenium-quantification-in-biological-samples-by-inductively-coupled-plasma-mass-spectrometry-icp-ms
#14
Véronique Vacchina, Jean Dumont
Selenium (Se) is an element readily absorbed during the intestinal tract, distributed in the body by means of blood and excreted mainly by urine or feces. Here, we describe the method allowing the determination of the total Se content in biological tissues and fluids by Inductively Coupled Plasma Mass Spectrometry (ICP MS).
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28915658/oxidative-stress-mediates-an-increased-formation-of-vascular-endothelial-growth-factor-in-human-hepatocarcinoma-cells-exposed-to-erlotinib
#15
Nataliya Rohr-Udilova, Florian Klinglmüller, Martha Seif, Hubert Hayden, Martin Bilban, Matthias Pinter, Klaus Stolze, Wolfgang Sieghart, Markus Peck-Radosavljevic, Michael Trauner
The tyrosine kinase inhibitor erlotinib targets the receptor of epidermal growth factor (EGFR) involved in development of hepatocellular carcinoma (HCC). Although inefficient in established HCC, erlotinib has been recently proposed for HCC chemoprevention. Since Cyp3A4 and Cyp1A2 enzymes metabolize erlotinib in the liver, the insights into the mechanisms of erlotinib effects on liver cells with maintained drug metabolizing activity are needed. We applied erlotinib to both commercially available (SNU398, Huh7) and established in Austria HCC cell lines (HCC-1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28906132/effects-of-different-dietary-sources-and-levels-of-selenium-supplements-on-growth-performance-antioxidant-status-and-immune-parameters-in-ross-308-broiler-chickens
#16
R Bakhshalinejad, Reza Akbari Moghaddam Kakhki, E Zoidis
1. Although different impacts of various sources of Selenium (Se) on chicken performance have been largely studied, there is a lack of comparative experiments studying the effects of these sources on immune system and antioxidant indices of broiler tissues. The aim of this study was to examine the effects of various sources and levels of dietary Se supplements on performance, antioxidant status and immune parameters in Ross 308 broiler chickens. 2. A total of 1200 one-day-old male broilers (Ross × Ross 308) were divided into 8 treatments with 6 replicate pens and 25 birds per pen...
September 14, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28906112/copper-i-catalyzed-ligand-promoted-multicomponent-reactions-of-isocyanides-selenium-amines-and-iodoarenes-access-to-highly-functionalized-carbamimidoselenoates
#17
Huan Liu, Yi Fang, Ling Yin, Shun-Yi Wang, Shun-Jun Ji
A new and facile approach towards highly functionalized carbamimidoselenoates was developed through the copper (I)-catalyzed ligand-promoted four-component reaction of isocyanides, selenium, amines, and aryl iodides. The reaction constructed a range of organoselenium compounds containing isoselenourea skeleton with potential bioactivity directly from selenium powder. The simplicity of method and the broad diversity of substrates also highlight this work.
September 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28904739/role-of-oxidative-stress-and-mitochondrial-dysfunction-in-sepsis-and-potential-therapies
#18
REVIEW
Konstantinos Mantzarlis, Vasiliki Tsolaki, Epaminondas Zakynthinos
Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28904300/hair-mercury-levels-in-relation-to-fish-consumption-among-vietnamese-in-hanoi
#19
Van Anh Thi Hoang, Hien Thu Thi Do, Tetsuro Agusa, Chihaya Koriyama, Suminori Akiba, Yasuhiro Ishibashi, Mineshi Sakamoto, Megumi Yamamoto
People are exposed to methylmercury (MeHg) mainly through fish consumption, which is increasing in Vietnam. However, little information is available on estimating the health risk of MeHg exposure through fish consumption in Vietnam. The present study examined the association between mercury (Hg) levels in hair and selenium (Se) levels in toenails of 196 Vietnamese people and their fish consumption, using a dietary questionnaire to obtain information pertinent for assessing health risk owing to MeHg exposure...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28904059/gene-methylation-biomarkers-in-sputum-and-plasma-as-predictors-for-lung-cancer-recurrence
#20
Steven A Belinsky, Shuguang Leng, Guodong Wu, Cynthia L Thomas, Maria A Picchi, Sandra J Lee, Seena Aisner, Suresh Ramalingam, Fadlo R Khuri, Daniel D Karp
Detection of methylated genes in exfoliated cells from the lungs of smokers provides an assessment of the extent of field cancerization, is a validated biomarker for predicting lung cancer, and provides some discrimination when interrogated in blood. The potential utility of this 8-gene methylation panel for predicting tumor recurrence has not been assessed. The Eastern Cooperative Oncology Group initiated a prevention trial (ECOG-ACRIN5597) that enrolled resected Stage I non-small cell lung cancer patients who were randomized 2:1 to receive selenized yeast versus placebo for four years...
September 13, 2017: Cancer Prevention Research
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