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https://www.readbyqxmd.com/read/28697075/posterolateral-bone-grafting-for-distal-tibia-nonunion
#1
Sanjit Konda, Hesham Saleh, Nina Fisher, Kenneth A Egol
INTRODUCTION: This video demonstrates the technique of posterolateral bone grafting with iliac crest bone graft for a distal tibial nonunion. METHODS: The patient is a 42-year-old man who is 6 months status post an open distal tibia-fibula fracture treated surgically, and presents complaints of persistent right ankle pain. The fracture site was tender to palpation, and 3 consecutive plain radiographs spaced 6 weeks apart demonstrated no evidence of callus formation...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28382732/engineering-vascularized-flaps-using-adipose-derived-microvascular-ec-and-msc
#2
Alina Freiman, Yulia Shandalov, Dekel Rosenfeld, Erez Shor, Dror Ben-David, Shai Meretzki, Shulamit Levenberg, Dana Egozi
Human adipose-derived microvascular endothelial cells (HAMEC) and mesenchymal stem cells (MSC) have been shown to bear angiogenic and vasculogenic capabilities. We hypothesize that co-culturing HAMEC:MSC on a porous biodegradable scaffold in vitro, later implanted as a graft around femoral blood vessels in a rat, will result in its vascularization by host vessels, creating a functional vascular flap that can effectively treat a range of large full-thickness soft tissue defects. HAMEC were co-cultured with MSC on polymeric 3D porous constructs...
April 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28375638/the-placenta-applications-in-orthopaedic-sports-medicine
#3
James Alexander McIntyre, Ian A Jones, Alla Danilkovich, C Thomas Vangsness
BACKGROUND: Placenta has a long history of use for treating burns and wounds. It is a rich source of collagen and other extracellular matrix proteins, tissue reparative growth factors, and stem cells, including mesenchymal stem cells (MSCs). Recent data show its therapeutic potential for orthopaedic sports medicine indications. PURPOSE: To provide orthopaedic surgeons with an anatomic description of the placenta, to characterize its cellular composition, and to review the literature reporting the use of placenta-derived cells and placental tissue allografts for orthopaedic sports medicine indications in animal models and in humans...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28297569/administration-of-adult-human-bone-marrow-derived-cultured-pooled-allogeneic-mesenchymal-stromal-cells-in-critical-limb-ischemia-due-to-buerger-s-disease-phase-ii-study-report-suggests-clinical-efficacy
#4
Pawan K Gupta, Murali Krishna, Anoop Chullikana, Sanjay Desai, Rajkumar Murugesan, Santanu Dutta, Uday Sarkar, Radhakrishnan Raju, Anita Dhar, Rajiv Parakh, Lakshmanan Jeyaseelan, Pachaiyappan Viswanathan, Prasanth Kulapurathu Vellotare, Raviraja N Seetharam, Charan Thej, Mathiyazhagan Rengasamy, Sudha Balasubramanian, Anish S Majumdar
Critical limb ischemia (CLI) due to Buerger's disease is a major unmet medical need with a high incidence of morbidity. This phase II, prospective, nonrandomized, open-label, multicentric, dose-ranging study was conducted to assess the efficacy and safety of i.m. injection of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (BMMSC) in CLI due to Buerger's disease. Patients were allocated to three groups: 1 and 2 million cells/kg body weight (36 patients each) and standard of care (SOC) (18 patients)...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28159040/recombinant-human-platelet-derived-growth-factor-bb-versus-autologous-bone-graft-in-foot-and-ankle-fusion-a-systematic-review-and-meta-analysis
#5
Han Sun, Pei-Pei Lu, Ping-Hui Zhou, Si-Wei Sun, Hong-Tao Zhang, Yi-Jie Liu, Xu Yang, Xiao-Feng Shen, Hui-Lin Yang
Today, autogenous bone graft (ABG) is still considered as the gold standard for joint fusion. Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) which is of chemotactic and mitogenic to mesenchymal stem cells and possesses outstanding osteogenetic potentials has been used for ankle and foot fusion in recent years. The goal of this article is to evaluate the safety and efficacy of rhPDGF-BB versus ABG in foot and ankle fusion. The PubMed MEDLINE, EMBASE, Web of Science, and Cochrane Library were systematic searched...
March 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#6
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although previous research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27871421/mesenchymal-stem-cell-bearing-sutures-for-tendon-repair-and-healing-in-the-foot-and-ankle
#7
REVIEW
Eric W Tan, Lew C Schon
Improving the quality and strength of soft tissue repairs remains an important area of orthopedic research and innovation. The need for immobilization and early motion is an important balance essential for the successful treatment of tendon repair and reconstruction. Mesenchymal stem cell (MSC)-bearing sutures represent an emerging biological augmentation to traditional suture repair. Two previous large studies using stem cell sutures in rat Achilles tendon models have demonstrated early increased biomechanical strength and significantly increased ultimate failure strength...
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27830541/achievement-of-disease-control-with-donor-derived-eb-virus-specific-cytotoxic-t-cells-after-allogeneic-peripheral-blood-stem-cell-transplantation-for-aggressive-nk-cell-leukemia
#8
Shojiro Haji, Motoaki Shiratsuchi, Takamitsu Matsushima, Akiko Takamatsu, Mariko Tsuda, Yasuhiro Tsukamoto, Emi Tanaka, Hirofumi Ohno, Eriko Fujioka, Yuriko Ishikawa, Ken-Ichi Imadome, Yoshihiro Ogawa
Aggressive NK-cell leukemia (ANKL) is characterized by systemic infiltration of Epstein-Barr virus (EBV)-associated natural killer cells and poor prognosis. We report a case of ANKL in which EBV-specific cytotoxic T lymphocytes (CTLs) were induced. A 41-year-old male suffered from fever, pancytopenia, and hepatosplenomegaly. The number of abnormal large granular lymphocytes in the bone marrow was increased and the cells were positive for CD56 and EBV-encoded small nuclear RNAs. The patient was diagnosed with ANKL and achieved a complete response following intensive chemotherapy...
April 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/27736950/episomal-induced-pluripotent-stem-cells-promote-functional-recovery-of-transected-murine-peripheral-nerve
#9
Charles Yuen Yung Loh, Aline Yen Ling Wang, Huang-Kai Kao, Esteban Cardona, Sheng-Hao Chuang, Fu-Chan Wei
Traumatic peripheral nerve neurotmesis occurs frequently and functional recovery is often slow and impaired. Induced pluripotent stem cells (iPSCs) have shown much promise in recent years due to its regenerative properties similar to that of embryonic stem cells. However, the potential of iPSCs in promoting the functional recovery of a transected peripheral nerve is largely unknown. This study is the first to investigate in vivo effects of episomal iPSCs (EiPSCs) on peripheral nerve regeneration in a murine sciatic nerve transection model...
2016: PloS One
https://www.readbyqxmd.com/read/27651981/improved-cartilage-regeneration-by-implantation-of-acellular-biomaterials-after-bone-marrow-stimulation-a-systematic-review-and-meta-analysis-of-animal-studies
#10
Michiel W Pot, Veronica K Gonzales, Pieter Buma, Joanna IntHout, Toin H van Kuppevelt, Rob B M de Vries, Willeke F Daamen
Microfracture surgery may be applied to treat cartilage defects. During the procedure the subchondral bone is penetrated, allowing bone marrow-derived mesenchymal stem cells to migrate towards the defect site and form new cartilage tissue. Microfracture surgery generally results in the formation of mechanically inferior fibrocartilage. As a result, this technique offers only temporary clinical improvement. Tissue engineering and regenerative medicine may improve the outcome of microfracture surgery. Filling the subchondral defect with a biomaterial may provide a template for the formation of new hyaline cartilage tissue...
2016: PeerJ
https://www.readbyqxmd.com/read/27651800/umbilical-cord-derived-mesenchymal-stem-cells-relieve-hindlimb-ischemia-through-enhancing-angiogenesis-in-tree-shrews
#11
Cunping Yin, Yuan Liang, Jian Zhang, Guangping Ruan, Zian Li, Rongqing Pang, Xinghua Pan
Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigated the role of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in regulating angiogenesis and relieving hindlimb ischemia. UC-MSCs were isolated from the umbilical cord of tree shrews. Angiography results showed that UC-MSCs injection significantly promoted angiogenesis in tree shrews...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27649406/comparing-the-efficacy-of-viable-cryopreserved-placental-membrane-for-the-treatment-of-wounds-of-diverse-etiologies
#12
Derek S Anselmo, Marc Karpo, Ebony Love, Tracey Vlahovic
INTRODUCTION AND OBJECTIVES: The benefits of using amniotic tissue in skin regeneration are well documented. Today, cryopreservation technology allows for better availability and maintenance of mesenchymal stem cells. This is of particular interest in treating the diabetic foot ulcer as this population has fewer mesenchymal stem cells. The objective of this case series investigation was to compare the efficacy of cryopreserved human amniotic stem cells in treating foot wounds of different etiologies...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27219884/clinical-evaluation-of-human-umbilical-cord-mesenchymal-stem-cell-transplantation-after-angioplasty-for-diabetic-foot
#13
H L Qin, X H Zhu, B Zhang, L Zhou, W Y Wang
Aims: The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. The present study evaluated the effects of HUCMSC transplantation after angioplasty for treatment of diabetic foot. Methods: Included in the study were 53 patients (72 limbs) with severe symptoms of Fontaine II-IV diabetic foot accompanied by varying degrees of lower extremity arterial disease. The patients were randomly apportioned to a control group (25 patients; 38 limbs) or an experimental group (28 patients; 34 limbs)...
September 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27206975/additional-mesenchymal-stem-cell-injection-improves-the-outcomes-of-marrow-stimulation-combined-with-supramalleolar-osteotomy-in-varus-ankle-osteoarthritis-short-term-clinical-results-with-second-look-arthroscopic-evaluation
#14
Yong Sang Kim, Moses Lee, Yong Gon Koh
BACKGROUND: Supramalleolar osteotomy (SMO) is reported to be an effective treatment for varus ankle osteoarthritis by redistributing the load line within the ankle joint. Mesenchymal stem cells (MSCs) have been proposed as a new treatment option for osteoarthritis on the basis of their cartilage regeneration ability. The purpose of this study was to compare the clinical, radiological, and second-look arthroscopic outcomes between MSC injection with marrow stimulation and marrow stimulation alone in patients with varus ankle osteoarthritis who have undergone SMO...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27151452/editorial-commentary-precise-nomenclature-is-critical-for-evaluating-progress-in-the-field-of-lipoaspirate-derived-stem-cell-therapy
#15
EDITORIAL
Lisa A Fortier
In a Level III study, the addition of adipose-based cell therapy significantly improved the clinical outcome and arthroscopic appearance of articular cartilage in patients with osteoarthritic varus ankles that were treated with the combinational operative techniques of lateral sliding calcaneal osteotomy and microfracture. Use of adipose-based therapies from lipoaspirate is increasing, with many different types of processing available, resulting in very different biological products. The mesenchymal stem cell therapy terminology used in the article could be more precise, and the contribution of adipose cells to the outcome is confounded by the surgical procedures performed...
May 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27026621/a-multi-center-analysis-of-adverse-events-among-two-thousand-three-hundred-and-seventy-two-adult-patients-undergoing-adult-autologous-stem-cell-therapy-for-orthopaedic-conditions
#16
Christopher J Centeno, Hasan Al-Sayegh, Michael D Freeman, Jay Smith, William D Murrell, Rostyslav Bubnov
INTRODUCTION: The purpose of the present investigation is to report on detailed complications among a much larger group of 2372 orthopaedic patients treated with stem cell injections who were followed in a treatment registry for up to nine years. METHODS: All patients underwent an MSC-based, percutaneous injection treatment of an orthopaedic condition between December 2005 and September 2014 at one of 18 clinical facilities. Treated areas of the body included the knee, hip, ankle/foot, hand/wrist, elbow, shoulder, and spine...
August 2016: International Orthopaedics
https://www.readbyqxmd.com/read/26993668/injection-of-mesenchymal-stem-cells-as-a-supplementary-strategy-of-marrow-stimulation-improves-cartilage-regeneration-after-lateral-sliding-calcaneal-osteotomy-for-varus-ankle-osteoarthritis-clinical-and-second-look-arthroscopic-results
#17
Yong Sang Kim, Yong Gon Koh
PURPOSE: To compare the clinical and second-look arthroscopic outcomes in patients undergoing arthroscopic marrow stimulation combined with lateral sliding calcaneal osteotomy for varus ankle osteoarthritis, with or without adipose-derived mesenchymal stem cell (MSC) injection. METHODS: In this retrospective comparative study, 49 patients with varus ankle osteoarthritis underwent second-look arthroscopy after arthroscopic marrow stimulation combined with lateral sliding calcaneal osteotomy between January 2010 and November 2012; 23 ankles underwent marrow stimulation alone (group 1), and 26 underwent marrow stimulation with MSC injection (group 2)...
May 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/26915003/joint-sparing-treatments-in-early-ankle-osteoarthritis-current-procedures-and-future-perspectives
#18
Francesco Castagnini, Camilla Pellegrini, Luca Perazzo, Francesca Vannini, Roberto Buda
Ankle osteoarthritis (AOA) is a severe pathology, mostly affecting a post-traumatic young population. Arthroscopic debridement, arthrodiastasis, osteotomy are the current joint sparing procedures, but, in the available studies, controversial results were achieved, with better outcomes in case of limited degeneration. Only osteotomy in case of malalignment is universally accepted as a joint sparing procedure in case of partial AOA. Recently, the biological mechanism of osteoarthritis has been intensively studied: it is a whole joint pathology, affecting cartilage, bone and synovial membrane...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/26914127/autologous-peripheral-blood-stem-cell-transplantation-to-treat-thromboangiitis-obliterans-preliminary-results
#19
J Wan, Y Yang, Z-H Ma, Y Sun, Y-Q Liu, G-J Li, G-M Zhang
OBJECTIVE: To investigate the efficiency of autologous peripheral blood stem cell transplantation (APBSCT) to treat severe the lower limbs ischemia caused by thromboangiitis obliterans (TAO). PATIENTS AND METHODS: From April 2007 to December 2014, a total of 64 patients with TAO (80 affected limbs) received APBSCT at our hospital. The treatment effect was evaluated by subjective indicators including pains and cold sensation of the affected limbs, combined with objective indicators including claudication distance, ankle brachial index (ABI), transcutaneous oxygen pressure (TcPO2) and skin temperature...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26904526/osteochondral-repair-in-hemophilic-ankle-arthropathy-from-current-options-to-future-perspectives
#20
Roberto Buda, Marco Cavallo, Francesco Castagnini, Enrico Ferranti, Simone Natali, Sandro Giannini
Young hemophilic patients are frequently affected by ankle arthropathy. At the end stage of the disease, the current treatments are arthrodesis and arthroplasty, which have significant drawbacks. Validated procedures capable of slowing down or even arresting the progression towards the end stage are currently lacking. This review aims to discuss the rationale for and feasibility of applying, in mild hemophilic ankle arthropathy, the main techniques currently used to treat osteochondral defects, focusing in particular on ankle distraction, chondrocyte implantation, mesenchymal stem cell transplantation, allograft transplantation and the use of growth factors...
October 2015: Joints
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