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Clinical pathway diagnostic test

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https://www.readbyqxmd.com/read/29675290/diagnostic-and-immunosuppressive-potential-of-elevated-mir-424-levels-in-circulating-immune-cells-of-ischemic-stroke-patients
#1
Guangwen Li, Qingfeng Ma, Rongliang Wang, Zhibin Fan, Zhen Tao, Ping Liu, Haiping Zhao, Yumin Luo
Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients with acute ischemic stroke (AIS). Blood samples were collected from 40 patients within 6 hours of symptom onset and 27 control subjects. MiR-424 levels in lymphocytes, neutrophils and plasma were determined by quantitative realtime-PCR...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29672267/point-of-care-creatinine-testing-for-kidney-function-measurement-prior-to-contrast-enhanced-diagnostic-imaging-evaluation-of-the-performance-of-three-systems-for-clinical-utility
#2
Beverly Snaith, Martine A Harris, Bethany Shinkins, Marieke Jordaan, Michael Messenger, Andrew Lewington
BACKGROUND: Acute kidney injury (AKI) can occur rarely in patients exposed to iodinated contrast and result in contrast-induced AKI (CI-AKI). A key risk factor is the presence of preexisting chronic kidney disease (CKD); therefore, it is important to assess patient risk and obtain kidney function measurement prior to administration. Point-of-care (PoC) testing provides an alternative strategy but there remains uncertainty, with respect to diagnostic accuracy and clinical utility. METHODS: A device study compared three PoC analysers (Nova StatSensor, Abbott i-STAT and Radiometer ABL800 FLEX) with a reference laboratory standard (Roche Cobas 8000 series, enzymatic creatinine)...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29670988/reducing-complications-and-overall-healthcare-costs-of-hip-fracture-management-a-retrospective-study-on-the-application-of-a-diagnostic-therapeutic-pathway-in-the-cosenza-general-hospital
#3
M Loizzo, F Gallo, D Caruso
BACKGROUND: Diagnostic Therapeutic Pathways (DTPs) are multidisciplinary plans designed by each healthcare organization for a specific category of patients to reduce the variability of professional behaviors and to ensure greater safety and better overall healthcare outcomes. Hip fractures are a frequent traumatic injury, particularly in the elderly, and DTPs recommend early surgical intervention, often not done due to organizational challenges and bureaucracy. Medical conditions suggesting a delay are not frequent, however long waiting times not only increase the risk of complications and mortality, but also increase the number of diagnostic test and physician consultations...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29667585/recent-developments-in-the-diagnosis-and-therapy-of-well-differentiated-neuroendocrine-tumours
#4
J Hofland, R A Feelders, T Brabander, G J H Franssen, W W de Herder
Well-differentiated neuroendocrine tumours (NETs) of the digestive tract are being increasingly detected, which is partly explained by the increased use of endoscopic and cross-sectional imaging as well as improved recognition at histopathological evaluation. After the discovery of this relatively indolent type of epithelial malignancy over 100 years ago, their sporadic occurrence and divergent biological behaviour at multiple primary sites have hampered dedicated studies into NET pathogenesis and testing of drug efficacy in well-designed clinical trials...
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29630107/linc00963-promotes-hepatocellular-carcinoma-progression-by-activating-pi3k-akt-pathway
#5
J-H Wu, X-Y Tian, Q-M An, X-Y Guan, C-Y Hao
OBJECTIVE: To explore the role of LINC00963 in the pathogenesis of hepatocellular carcinoma and its underlying mechanisms. PATIENTS AND METHODS: The expression level of LINC00963 in 48 cases of hepatocellular carcinoma (HCC) tissues and paracancerous tissues were detected by quantitative Real-time (qRT-PCR). Survival analysis was carried out based on the expression level of LINC00963. The association between the expression level of LINC00963 and clinical characteristics of these subjects was analyzed by x2-test...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29626633/serum-lipoproteins-are-not-associated-with-the-severity-of-asthma
#6
Federica Scaduto, Rosaria Vincenza Giglio, Alida Benfante, Dragana Nikolic, Giuseppe Montalto, Manfredi Rizzo, Nicola Scichilone
BACKGROUND: Asthma is a chronic inflammatory disorder of the bronchi with a complicated and largely unknown pathogenesis. In this context, an emerging role is attributed to the apolipoproteins which serve as structural components of plasma lipoproteins. Low density lipoproteins (LDL) may be involved in the inflammatory pathways of the asthmatic airways; in particular, small dense LDL (sdLDL) particles were associated with increased oxidative susceptibility compared to medium and large sized LDL...
April 4, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29626249/molecular-markers-in-well-differentiated-thyroid-cancer
#7
REVIEW
Anil K D'Cruz, Richa Vaish, Abhishek Vaidya, Iain J Nixon, Michelle D Williams, Vincent Vander Poorten, Fernando López, Peter Angelos, Ashok R Shaha, Avi Khafif, Alena Skalova, Alessandra Rinaldo, Jennifer L Hunt, Alfio Ferlito
PURPOSE: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29625392/the-current-landscape-of-nucleic-acid-tests-for-filovirus-detection
#8
REVIEW
David J Clark, John Tyson, Andrew D Sails, Sanjeev Krishna, Henry M Staines
Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed. Tests that can identify a pathogen in the initial stages of infection are essential to control outbreaks. Since the Ebola virus disease (EVD) outbreak in 2014-2016 several tests have been developed that are faster than previous tests and more suited for field use. Furthermore, the ability to test for a range of pathogens simultaneously has been expanded to improve clinical pathway management of febrile syndromes...
March 22, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29599694/utilization-of-clinical-pathway-on-open-appendectomy-a-quality-improvement-initiative-in-a-private-hospital-in-the-philippines
#9
Allan L Hilario, Jonathan David H Oruga, Maria Presentacion B Turqueza, Donnatella V Hilario
Objective: This study was done to evaluate the utilization of clinical pathway (CP) on open appendectomy as a quality improvement (QI) initiative. Methods: The CP document was developed from the clinical practice guideline created by the Philippine College of Surgeons using an event-timeline tabular checklist format. After a hospital-wide education, the CP was implemented on January 1, 2010, as the QI intervention. Appendectomies done 4 years before the intervention were assigned to the pre-pathway group while those done 5 years after were assigned to the post-pathway group...
March 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#10
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29581049/towards-precision-medicine-in-sepsis-a-position-paper-from-the-european-society-of-clinical-microbiology-and-infectious-diseases
#11
Jordi Rello, Tjitske S R van Engelen, Emine Alp, Thierry Calandra, Vincent Cattoir, Winfried V Kern, Mihai G Netea, Saad Nseir, Steven M Opal, Frank L van de Veerdonk, Mark H Wilcox, W Joost Wiersinga
BACKGROUND: Our current understanding of the pathophysiology and management of sepsis is associated with a lack of progress in clinical trials, which partly reflects insufficient appreciation of the heterogeneity of this syndrome. Consequently, more patient specific approaches to treatment should be explored. AIMS: To summarize the current evidence on precision medicine in sepsis, with an emphasis on translation from theory to clinical practice. A secondary objective is to develop a framework enclosing recommendations on management and priorities for further research...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29574006/a-rapid-screening-of-a-recurrent-cyp24a1-pathogenic-variant-opens-the-way-to-molecular-testing-for-idiopathic-infantile-hypercalcemia-iih
#12
Elisa De Paolis, Angelo Minucci, Maria De Bonis, Giovanni Luca Scaglione, Jacopo Gervasoni, Aniello Primiano, Pietro Manuel Ferraro, Daniele Cappellani, Claudio Marcocci, Giovanni Gambaro, Ettore Capoluongo
INTRODUCTION: Loss-of-function mutations in cytochrome P450 family 24 subfamily A member 1 (CYP24A1) gene are associated with Idiopathic Infantile Hypercalcemia (IIH) and adult kidney stone disease. The enzyme deficiency leads to an impaired vitamin D catabolism pathway, resulting in a syndrome characterized by recurrent hypercalcemia, hypercalciuria and suppressed parathyroid hormone (PTH) levels. In these patients, the genetic evaluation of CYP24A1 is an important diagnostic tool, allowing the definitive diagnosis of IIH...
March 21, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29566381/the-research-cycle-improving-care-and-outcomes-for-newborn-infants
#13
William McGuire, Henry L Halliday
Ensuring that policies and practice in perinatal care are informed by evidence from high-quality research is fundamental to improving outcomes for newborn infants and their families. Effective interventions in the perinatal period can have a life-long impact disproportionate to their costs. Many of the major advances in care that have transformed outcomes for preterm and sick newborn infants have been informed by empirical and applied health research. Conversely, there are examples of life-long adverse consequences for infants and families that are a legacy of practices based on poor-quality evidence...
March 22, 2018: Neonatology
https://www.readbyqxmd.com/read/29562894/from-symptom-discovery-to-treatment-women-s-pathways-to-breast-cancer-care-a-cross-sectional-study
#14
Jennifer Moodley, Lydia Cairncross, Thurandrie Naiker, Deborah Constant
BACKGROUND: Typically, women in South Africa (SA) are diagnosed with breast cancer when they self-present with symptoms to health facilities. The aim of this study was to determine the pathway that women follow to breast cancer care and factors associated with this journey. METHODS: A cross-sectional study was conducted at a tertiary hospital in the Western Cape Province, SA, between May 2015 and May 2016. Newly diagnosed breast cancer patients were interviewed to determine their socio-demographic profile; knowledge of risk factors, signs and symptoms; appraisal of breast changes; clinical profile and; key time events in the journey to care...
March 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29562524/revolution-of-alzheimer-precision-neurology-passageway-of-systems-biology-and-neurophysiology
#15
Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L Black, Arun L W Bokde, René S Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Jean Lorenceau, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Craig Ritchie, Simone Rossi, Emiliano Santarnecchi, Olaf Sporns, Steven R Verdooner, Andrea Vergallo, Nicolas Villain, Erfan Younesi, Francesco Garaci, Simone Lista
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an "omics"-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical, and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND...
March 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29559205/a-clinical-evaluation-of-placental-growth-factor-in-routine-practice-in-high-risk-women-presenting-with-suspected-pre-eclampsia-and-or-fetal-growth-restriction
#16
L Ormesher, E D Johnstone, E Shawkat, A Dempsey, C Chmiel, E Ingram, L E Higgins, J E Myers
OBJECTIVE: To evaluate the use of plasma Placental Growth Factor (PlGF), recommended by the recent NICE guidance, in women with suspected pre-eclampsia (PE) and/or fetal growth restriction (FGR). STUDY DESIGN: Non-randomised prospective clinical evaluation study in high-risk antenatal clinics in a tertiary maternity unit. METHODS: PlGF testing was performed in addition to routine clinical assessment in 260 women >20 weeks' gestation with chronic disease (hypertension, renal disease ± diabetes) with a change in maternal condition or in women with suspected FGR to determine the impact on clinical management...
March 13, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29556190/promising-metabolite-profiles-in-the-plasma-and-csf-of-early-clinical-parkinson-s-disease
#17
Daniel Stoessel, Claudia Schulte, Marcia C Teixeira Dos Santos, Dieter Scheller, Irene Rebollo-Mesa, Christian Deuschle, Dirk Walther, Nicolas Schauer, Daniela Berg, Andre Nogueira da Costa, Walter Maetzler
Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29549867/real-time-non-instrumented-clinical-gait-analysis-as-part-of-a-clinical-musculoskeletal-assessment-in-the-treatment-of-lower-limb-symptoms-in-adults-a-systematic-review
#18
REVIEW
Paul Harradine, Lucy Gates, Catherine Bowen
BACKGROUND: The aim of this review was to evaluate and summarise the current evidence on non-computerised or non-recorded real time adult gait assessment conducted within the clinical musculoskeletal setting. It was hoped a protocol for best practice and a framework for further research could be developed from this search. RESEARCH QUESTION: Can a protocol for best practice and a framework for further research be established from previous literature relating to non-computerised or non-recorded real time adult gait analysis in a musculoskeletal clinical setting...
March 8, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29547642/-before-xpert-i-only-had-my-expertise-a-qualitative-study-on-the-utilization-and-effects-of-xpert-technology-among-pediatricians-in-4-indian-cities
#19
Andrew McDowell, Neeraj Raizada, Sunil D Khaparde, Raghuram Rao, Sanjay Sarin, Aakshi Kalra, Virender Singh Salhotra, Sreenivas Achuthan Nair, Catharina Boehme, Claudia M Denkinger
BACKGROUND: Diagnosing tuberculosis (TB) in children presents considerable challenges. Upfront testing on Xpert® MTB/RIF ('Xpert')-a rapid molecular assay with high sensitivity and specificity-for pediatric presumptive TB patients, as recommended by India's Revised National Tuberculosis Control Program (RNTCP), can pave the way for early TB diagnosis. As part of an ongoing project implemented by Foundation for Innovative New Diagnostics (FIND) dedicated to providing upfront free-of-cost (FOC) Xpert testing to children seeking care in the public and private sectors, a qualitative assessment was designed to understand how national guidelines on TB diagnosis and Xpert technology have been integrated into the pediatric TB care practices of different health providers...
2018: PloS One
https://www.readbyqxmd.com/read/29528972/the-role-of-urodynamics-in-the-surgical-management-of-benign-prostatic-obstruction
#20
Matthew G Crockett, Marcus J Drake
PURPOSE OF REVIEW: Benign prostatic obstruction (BPO) is a common cause of lower urinary tract symptoms (LUTS) in elderly men. However, such symptoms are often caused by primary detrusor overactivity or underactivity. Surgical management where BPO is absent or merely incidental has a lower chance of success, and exposes the patient to the potential complications of surgery. This review discusses the diagnostic challenges facing this common presentation. RECENT FINDINGS: Most evidence comes from small, historical prospective cohort studies...
May 2018: Current Opinion in Urology
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