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https://www.readbyqxmd.com/read/28734225/adverse-effects-of-methylmercury-mehg-on-life-parameters-antioxidant-systems-and-mapk-signaling-pathways-in-the-rotifer-brachionus-koreanus-and-the-copepod-paracyclopina-nana
#1
Young Hwan Lee, Duck-Hyun Kim, Hye-Min Kang, Minghua Wang, Chang-Bum Jeong, Jae-Seong Lee
To evaluate the adverse effects of MeHg on the rotifer Brachionus koreanus and the copepod Paracyclopina nana, we assessed the effects of MeHg toxicity on life parameters (e.g. growth retardation and fecundity), antioxidant systems, and mitogen-activated protein kinase (MAPK) signaling pathways at various concentrations (1ng/L, 10ng/L, 100ng/L, 500ng/L, and 1000ng/L). MeHg exposure resulted in the growth retardation with the increased ROS levels but decreased glutathione (GSH) levels in a dose-dependent manner in both B...
July 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28734173/reliability-and-validity-of-the-tilburg-frailty-indicator-tfi-among-chinese-community-dwelling-older-people
#2
Lijuan Dong, Na Liu, Xiaoyu Tian, Xiaoxia Qiao, Robbert J J Gobbens, Robert L Kane, Cuili Wang
OBJECTIVE: To translate the Tilburg Frailty Indicator (TFI) into Chinese and assess its reliability and validity. METHODS: A sample of 917 community-dwelling older people, aged ≥60 years, in a Chinese city was included between August 2015 and March 2016. Construct validity was assessed using alternative measures corresponding to the TFI items, including self-rated health status (SRH), unintentional weight loss, walking speed, timed-up-and-go tests (TUGT), making telephone calls, grip strength, exhaustion, Short Portable Mental Status Questionnaire (SPMSQ), Geriatric Depression scale (GDS-15), emotional role, Adaptability Partnership Growth Affection and Resolve scale (APGAR) and Social Support Rating Scale (SSRS)...
July 15, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28734152/trajectories-of-alcohol-use-in-the-uk-military-and-associations-with-mental-health
#3
L Goodwin, S Norton, N T Fear, M Jones, L Hull, S Wessely, R J Rona
INTRODUCTION: There are higher levels of alcohol misuse in the military compared to the general population. Yet there is a dearth of research in military populations on the longitudinal patterns of alcohol use. This study aims to identify group trajectories of alcohol consumption in the UK military and to identify associations with childhood adversity, deployment history and mental disorder. METHODS: Data on weekly alcohol consumption across an eight year period and three phases of a UK military cohort study (n=667) were examined using growth mixture modelling...
July 12, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28732390/a-novel-hitch-and-ride-deep-biliary-cannulation-method-during-rendezvous-endoscopic-ultrasound-guided-ercp-technique
#4
Yousuke Nakai, Hiroyuki Isayama, Saburo Matsubara, Hirofumi Kogure, Suguru Mizuno, Tsuyoshi Hamada, Naminatsu Takahara, Tomoka Nakamura, Tatsuya Sato, Tsuyoshi Takeda, Ryunosuke Hakuta, Kazunaga Ishigaki, Kei Saito, Minoru Tada, Kazuhiko Koike
Background and study aim Endoscopic ultrasound-guided rendezvous (EUS-RV) is increasingly reported as a treatment option after failed endoscopic retrograde cholangiopancreatography. We developed a novel "hitch-and-ride" catheter for biliary cannulation to reduce the risk of guidewire loss during EUS-RV. Patients and methods We retrospectively evaluated safety and technical success of EUS-RV between June 2011 and May 2016. Biliary cannulation during EUS-RV using three methods - over-the-wire, along-the-wire, and hitch-and-ride - were compared...
July 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28732381/lymph-node-ratio-but-not-the-total-number-of-examined-lymph-nodes-or-lymph-node-metastasis-is-a-predictor-of-overall-survival-for-pancreatic-neuroendocrine-neoplasms-after-surgical-resection
#5
Peng Liu, Xianbin Zhang, Yuru Shang, Lili Lu, Fei Cao, Min Sun, Zhaohui Tang, Brigitte Vollmar, Peng Gong
AIM: To evaluate the prognostic significance of lymph node metastasis, extent of examined lymph nodes (ELNs) and lymph node ratio (LNR) for resected pancreatic neuroendocrine neoplasms (pNENs). MATERIALS AND METHODS: Surgically resected pNENs were assimilated from the Surveillance, Epidemiology, and End Results database. Kaplan-Meier and Cox proportional hazard models were used to examine the prognostic effect of clinicopathological characteristics on overall survival; Harrell's concordance index was performed to assess the prognostic accuracy of all independent prognostic factors; and the Spearman's rank correlation was used to assess the correlation between LNR and other clinicopathological characteristics...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732372/combined-ki67-and-ercc1-for-prognosis-in-non-keratinizing-nasopharyngeal-carcinoma-underwent-chemoradiotherapy
#6
Ying Lu, Haixin Huang, Min Kang, Min Yi, Hui Yang, Sibei Wu, Rensheng Wang
This study aimed to assess the predictive value of combined Ki67 and ERCC1 in distant metastasis-free nasopharyngeal carcinoma. 334 such cases were retrospectively assessed. Immunohistochemistry was used to evaluate Ki67 and ERCC1 protein levels in tumor tissues. Associations of Ki67 and ERCC1 amounts with clinical characteristics and survival were analyzed. Medium follow-up was 48.7 months; overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) were 91...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732354/influence-of-body-mass-index-on-postoperative-complications-after-thymectomy-in-myasthenia-gravis-patients
#7
Xu-Dong Liu, Ming-Rui Shao, Lei Sun, Lin Zhang, Xin-Shan Jia, Wen-Ya Li
OBJECTIVES: It is not clear whether being overweight or obese influences postoperative complications in myasthenia gravis (MG) patients. We retrospectively investigated an association between body mass index (BMI) and postoperative complications in MG. MATERIALS AND METHODS: Fifty-nine MG patients who had undergone transsternal thymectomy were classified as low or high BMI based on the criteria for Asian-Pacific populations. An association between BMI and complications was analyzed...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732349/intracoronary-administration-of-tirofiban-during-percutaneous-coronary-intervention-facilitates-patients-with-acute-coronary-syndrome
#8
Helei Jia, Changqing Lu, Panli Sun
We assessed the efficacy and safety of tirofiban intracoronary versus intravenous administration during percutaneous coronary intervention for patients with acute coronary syndrome. The databases of PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang Database were retrieved. A total of 437 articles were found, according to inclusive and exclusive criteria, 13 of which were finally included. Compared with subjects with intravenous administration, those with intracoronary administration were more likely to reach thrombolysis in myocardial infarction trial grade 3 flow (relative risk = 1...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732338/toxic-organic-substances-and-marker-compounds-in-size-segregated-urban-particulate-matter-implications-for-involvement-in-the-in%C3%A2-vitro-bioactivity-of-the-extractable-organic-matter
#9
Athanasios Besis, Alexandra Tsolakidou, Dimitra Balla, Constantini Samara, Dimitra Voutsa, Anastasia Pantazaki, Theodora Choli-Papadopoulou, Theodore S Lialiaris
Toxic organic substances and polar organic marker compounds, i.e. polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs) and their nitro-derivatives (N-PAHs), as well as dicarboxylic acids (DCAs) and sugars/sugar anhydrites (S/SAs) were analyzed in size-segregated PM samples (<0.49, 0.49-0.97, 0.97-3 and >3 μm) collected at two urban sites (urban traffic and urban background) during the cold and the warm season...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28732314/the-effect-of-low-dose-furosemide-in-critically-ill-patients-with-early-acute-kidney-injury-a-pilot-randomized-blinded-controlled-trial-the-spark-study
#10
Sean M Bagshaw, R T Noel Gibney, Peter Kruger, Imran Hassan, Finlay A McAlister, Rinaldo Bellomo
PURPOSE: Furosemide is commonly prescribed in acute kidney injury (AKI). Prior studies have found conflicting findings on whether furosemide modifies the course and outcome of AKI. METHODS: Pilot multi-center randomized blinded placebo-controlled trial in adult patients with AKI admitted to three intensive care units. Participants were randomly allocated to furosemide bolus and infusion or 0.9% saline placebo. Primary endpoint was worsening AKI, defined by the RIFLE criteria...
July 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28732306/photostability-testing-using-online-reactor-hplc-hyphenation-and-mass-spectrometric-compound-identification-illustrated-by-ketoprofen-as-model-compound
#11
Jaber Assaf, Diego Zulkiewicz Gomes, Bernhard Wuest, Maria Kristina Parr
Investigations on the photochemical stability of pharmaceutical substances are mandatory in drug development and licensing as photo-induced degradation of an active pharmaceutical ingredient (API) may not only lead to decreased API concentrations but also to toxic or reactive products. Thus, the US Food and Drug Administration (FDA) and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) issued Guidance for Industry Q1B "Photostability Testing of New Drug Substances and Products" for testing of pure but also packed drugs...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28732239/effects-of-antiepileptic-drugs-on-mitochondrial-functions-morphology-kinetics-biogenesis-and-survival
#12
REVIEW
Josef Finsterer, Fulvio A Scorza
OBJECTIVES: Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on mitochondria, which have a strong impact on the treatment of patients with a mitochondrial disorder (MID) with epilepsy (mitochondrial epilepsy). This review aims at summarizing and discussing recent findings concerning the effect of AEDs on mitochondrial functions and the clinical consequences with regard to therapy of mitochondrial epilepsy and of MIDs in general. METHODS: Literature review...
July 13, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28732219/perioperative-systemic-corticosteroids-in-orthognathic-surgery-a-systematic-review-and-meta-analysis
#13
REVIEW
Simon Jean, Pierre-Luc Dionne, Carl Bouchard, Luc Giasson, Alexis F Turgeon
PURPOSE: Perioperative systemic corticosteroids are broadly used in orthognathic surgery to prevent postoperative complications, but it is unclear whether this practice is beneficial and concerns about potential side effects have been raised. The purpose of this systematic review and meta-analysis was to assess the effects of perioperative systemic corticosteroids on clinically important outcomes in patients undergoing orthognathic surgery. MATERIALS AND METHODS: The authors conducted a systematic review of randomized controlled trials evaluating the effect of systemic corticosteroids in orthognathic surgery compared with placebo or any other intervention...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732218/invasiveness-of-tibial-bone-graft-harvesting-for-secondary-alveolar-bone-grafting-can-harvesting-be-made-at-the-age-of-less-than-10%C3%A2-years-without-complications
#14
Kohta Fukuta, Kenichi Kurita, Atsushi Nakayama, Masahito Maeda, Hiroshi Watanabe, Mitsuo Goto
PURPOSE: In this study, particulate cancellous bone marrow was harvested from the tibia for alveolar bone grafting, and postoperative complications at the donor site were compared between patients aged 10 years or older (29 tibias) and those aged younger than 10 years (42 tibias). PATIENTS AND METHODS: Enrolled patients were those who underwent tibial bone graft harvesting at the Department of Oral and Maxillofacial Surgery, Aichi Gakuin University, during a period of 3 years and 1 month from March 2012 through March 2015...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732198/primary-cell-phenotypic-screening-illuminates-adrs-and-aops
#15
Audrey J Bone, Keith A Houck
Preclinical, in vitro screening for adverse drug reactions continues to present challenges in the field of drug development. In this issue of Cell Chemical Biology, Shah et al. (2017) employ a phenotypic screening strategy using a panel of human primary cells to define a signature response and an adverse outcome pathway for delayed type IV skin hypersensitivity.
July 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#16
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28732090/incidence-predictors-and-severity-of-adverse-events-among-whole-blood-donors
#17
Hamdan Almutairi, Mahmoud Salam, Abdulaziz Alajlan, Faisal Wani, Bushra Al-Shammari, Khaled Al-Surimi
BACKGROUND: Adverse events have been reported post blood donation. Donors might refrain from donating again due to such events which lowers the blood supply in collection centers. AIM: This study measured the incidence, predictors and severity of adverse events among donors of a single whole blood unit at one of the largest donation centers in Saudi Arabia. METHODS: A retrospective cohort was conducted in 2015 to investigate the adverse events immediately post donation...
2017: PloS One
https://www.readbyqxmd.com/read/28732073/first-trimester-fetal-growth-restriction-and-the-occurrence-of-miscarriage-in-rural-bangladesh-a-prospective-cohort-study
#18
Harunor Rashid, Enbo Ma, Farzana Ferdous, Eva-Charlotte Ekström, Yukiko Wagatsuma
Fetal growth restriction in early pregnancy increases the risk of adverse pregnancy outcome, which has a significant social and psychological impact on women. There is limited information related to community-based study to evaluate early indicators related to miscarriage. The aim of this study is to examine the relationship between fetal growth restriction, measured by ultrasound crown-rump length (CRL), and subsequent occurrence of miscarriage in pregnant women in rural Bangladesh. The study was conducted within the Maternal and Infant Nutrition Interventions Trial in Matlab (MINIMat study), Bangladesh...
2017: PloS One
https://www.readbyqxmd.com/read/28732067/thromboembolic-adverse-event-study-of-combined-estrogen-progestin-preparations-using-japanese-adverse-drug-event-report-database
#19
Shiori Hasegawa, Toshinobu Matsui, Yuuki Hane, Junko Abe, Haruna Hatahira, Yumi Motooka, Sayaka Sasaoka, Akiho Fukuda, Misa Naganuma, Kouseki Hirade, Yukiko Takahashi, Yasutomi Kinosada, Mitsuhiro Nakamura
Combined estrogen-progestin preparations (CEPs) are associated with thromboembolic (TE) side effects. The aim of this study was to evaluate the incidence of TE using the Japanese Adverse Drug Event Report (JADER) database. Adverse events recorded from April 2004 to November 2014 in the JADER database were obtained from the Pharmaceuticals and Medical Devices Agency (PMDA) website (www.pmda.go.jp). We calculated the reporting odds ratios (RORs) of suspected CEPs, analyzed the time-to-onset profile, and assessed the hazard type using Weibull shape parameter (WSP)...
2017: PloS One
https://www.readbyqxmd.com/read/28732031/breast-tissue-ablation-with-irreversible-electroporation-in-rabbits-a-safety-and-feasibility-study
#20
Wenlong Zhang, Wanning Wang, Wei Chai, Xiaomei Luo, Jiannan Li, Jian Shi, Liqi Bi, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit. METHODS: Thirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation...
2017: PloS One
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