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https://www.readbyqxmd.com/read/28821939/analgesic-use-in-patients-with-knee-and-or-hip-osteoarthritis-referred-to-an-outpatient-center-a-cross-sectional-study-within-the-amsterdam-osteoarthritis-cohort
#1
Jesper Knoop, Joyce van Tunen, Martin van der Esch, Leo D Roorda, Joost Dekker, Marike van der Leeden, Willem F Lems
Although analgesics are widely recommended in current guidelines, underuse and inadequate prescription of analgesics seem to result in suboptimal treatment effects in patients with knee and/or hip osteoarthritis (OA). This study aimed (i) to describe the use of analgesics; and (ii) to determine factors that are related to analgesic use in patients with knee and/or hip OA referred to an outpatient center. A cross-sectional study with data from 656 patients with knee and/or hip OA referred to an outpatient center (Amsterdam Osteoarthritis (AMS-OA) cohort) was conducted...
August 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28790339/preventing-inflammation-inhibits-biopsy-mediated-changes-in-tumor-cell-behavior
#2
Maria Alieva, Andreia S Margarido, Tamara Wieles, Erik R Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J Snijders, Marike L Broekman, Jacco van Rheenen
Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induces migration and proliferation of tumor cells through chemokine (C-C motif) ligand 2 (CCL-2)-dependent recruitment of macrophages...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771582/distinct-radiation-responses-after-in-vitro-mtdna-depletion-are-potentially-related-to-oxidative-stress
#3
Marike W van Gisbergen, An M Voets, Rianne Biemans, Roland F Hoffmann, Marie-José Drittij-Reijnders, Guido R M M Haenen, Irene H Heijink, Kasper M A Rouschop, Ludwig J Dubois, Philippe Lambin
Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content, attributed to altered reactive oxygen species (ROS) production and antioxidant capacity. For this purpose BEAS-2B, A549, and 143B cell lines were depleted from their mtDNA (ρ0). Overall survival after irradiation was increased (p<0.001) for BEAS-2B ρ0 cells, while decreased for both tumor ρ0 lines (p<0...
2017: PloS One
https://www.readbyqxmd.com/read/28749305/the-pharmacokinetics-of-topical-itraconazole-in-panamanian-golden-frogs-atelopus-zeteki
#4
Amy Rifkin, Marike Visser, Kevin Barrett, Dawn Boothe, Ellen Bronson
Chytridiomycosis is caused by the fungus Batrachochytrium dendrobatidis and is one of the primary causes of the global decline in amphibian populations and specifically of the Panamanian golden frog ( Atelopus zeteki ). Itraconazole has been demonstrated to be an effective treatment for chytridiomycosis by inhibiting cytochrome P450, a major enzyme important for the structure of B. dendrobatidis zoospores' plasma membranes. However, anecdotal reports of toxicity in this and other amphibian species have been reported at the 0...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28739448/hydrocortisone-and-ascorbic-acid-synergistically-prevent-and-repair-lps-induced-pulmonary-endothelial-barrier-dysfunction
#5
Nektarios Barabutis, Vikramjit Khangoora, Paul E Marik, John D Catravas
BACKGROUND: Sepsis refers the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is strongly associated with vascular dysfunction and elevated pulmonary capillary permeability. We recently reported that the combination of hydrocortisone (HC), ascorbic acid (VitC) and thiamine dramatically improves outcomes and reduces mortality in septic patients...
July 21, 2017: Chest
https://www.readbyqxmd.com/read/28738108/prevalence-course-and-associated-factors-of-pain-in-the-temporomandibular-joint-in-early-rheumatoid-arthritis-results-of-a-longitudinal-cohort-study
#6
Jessica P Chin Jen Sem, Marike van der Leeden, Corine M Visscher, Karin Britsemmer, Samina A Turk, Joost Dekker, Dirkjan van Schaardenburg, Frank Lobbezoo
AIMS: To assess the prevalence, 3-year course, and associated factors of temporomandibular joint (TMJ) pain in patients with newly diagnosed rheumatoid arthritis (RA). METHODS: A total of 264 patients with newly diagnosed RA were included. Patients were assessed after 3 months, 6 months, 9 months, 1 year, 1.5 years, 2 years, and 3 years. TMJ pain was scored by manual palpation, and the prevalence of TMJ pain was calculated at baseline and at all seven follow-up intervals during 3 years...
2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28734265/decreased-lung-function-with-mediation-of-blood-parameters-linked-to-e-waste-lead-and-cadmium-exposure-in-preschool-children
#7
Xiang Zeng, Xijin Xu, H Marike Boezen, Judith M Vonk, Weidong Wu, Xia Huo
Blood lead (Pb) and cadmium (Cd) levels have been associated with lower lung function in adults and smokers, but whether this also holds for children from electronic waste (e-waste) recycling areas is still unknown. To investigate the contribution of blood heavy metals and lung function levels, and the relationship among living area, the blood parameter levels, and the lung function levels, a total of 206 preschool children from Guiyu (exposed area), and Haojiang and Xiashan (reference areas) were recruited and required to undergo blood tests and lung function tests during the study period...
July 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28694797/genome-data-provides-high-support-for-generic-boundaries-in-burkholderia-sensu-lato
#8
Chrizelle W Beukes, Marike Palmer, Puseletso Manyaka, Wai Y Chan, Juanita R Avontuur, Elritha van Zyl, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, T B K Reddy, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Nikos Kyrpides, Tanja Woyke, Jochen Blom, William B Whitman, Stephanus N Venter, Emma T Steenkamp
Although the taxonomy of Burkholderia has been extensively scrutinized, significant uncertainty remains regarding the generic boundaries and composition of this large and heterogeneous taxon. Here we used the amino acid and nucleotide sequences of 106 conserved proteins from 92 species to infer robust maximum likelihood phylogenies with which to investigate the generic structure of Burkholderia sensu lato. These data unambiguously supported five distinct lineages, of which four correspond to Burkholderia sensu stricto and the newly introduced genera Paraburkholderia, Caballeronia, and Robbsia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28687317/effect-of-soft-braces-on-pain-and-physical-function-in-patients-with-knee-osteoarthritis-systematic-review-with-meta-analyses
#9
REVIEW
Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Leo D Roorda, Jari Pallari, Kim L Bennell, Hans Lund, Joost Dekker
OBJECTIVE: To systematically review and synthesize the effect of soft braces on pain, and self-reported and performance-based physical function in patients with knee osteoarthritis. DATA SOURCES: The following electronic databases were searched from inception to April 20, 2016: The Cochrane Central Registry for Controlled Trials (CENTRAL), PubMed, EMBASE, CINAHL, SportDiscuss, Web of Science and PEDro. STUDY SELECTION: Randomized controlled trials (RCT) and non-randomized controlled trials (non-RCTs), such as controlled clinical trials, crossover studies and case-control studies were included...
July 4, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28661545/nonlinear-relationship-between-isokinetic-muscle-strength-and-activity-limitations-in-patients-with-knee-osteoarthritis-results-of-the-amsterdam-osteoarthritis-cohort
#10
Lisa M Edelaar, Jaap H van Dieën, Martin van der Esch, Leo D Roorda, Joost Dekker, Willem F Lems, Marike van der Leeden
OBJECTIVE: To investigate whether relationships between upper leg muscle strength and activity limitations are non-linear in patients with knee osteoarthritis, and, if so, to determine muscle strength thresholds for limitations in daily activities. DESIGN: Baseline data were used for 562 patients with knee osteoarthritis in the Amsterdam-Osteoarthritis cohort. Upper leg muscle strength (Nm/kg) was measured isokinetically. Activity limitations were measured with the timed Get Up and Go test and timed Stair Climb Test, subdivided into stair-ascent and stair-descent...
June 29, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28646895/stereotactic-radiosurgery-versus-whole-brain-radiotherapy-after-intracranial-metastasis-resection-a-systematic-review-and-meta-analysis
#11
REVIEW
Nayan Lamba, Ivo S Muskens, Aislyn C DiRisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J C Verhoeff, Catharina E Kleynen, Timothy R Smith, Rania A Mekary, Marike L Broekman
BACKGROUND: In patients with one to three brain metastases who undergo resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the resection cavity. In this meta-analysis, we sought to compare the efficacy of each post-operative radiation modality with respect to tumor recurrence and survival. METHODS: Pubmed, Embase and Cochrane databases were searched through June 2016 for cohort studies reporting outcomes of SRS or WBRT after metastasis resection...
June 24, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28643208/visual-outcomes-after-endoscopic-endonasal-pituitary-adenoma-resection-a-systematic-review-and-meta-analysis
#12
REVIEW
Ivo S Muskens, Amir H Zamanipoor Najafabadi, Vanessa Briceno, Nayan Lamba, Joeky T Senders, Wouter R van Furth, Marco J T Verstegen, Timothy R S Smith, Rania A Mekary, Christine A E Eenhorst, Marike L D Broekman
PURPOSE: Patients with pituitary adenomas often present with visual deficits. While the aim of endoscopic endonasal transsphenoidal surgery (EETS) is to improve these deficits, permanent worsening is a possible outcome. The aim of this meta-analysis was to evaluate the effect of EETS for pituitary adenomas on visual outcomes. METHODS: A meta-analysis was conducted according to the PRISMA guidelines. Pooled prevalence was calculated for complete recovery, improvement, and deterioration of visual field deficits, visual acuity and unspecified visual function in fixed- and random-effect models, including assessment of heterogeneity (I(2)) and publication bias (Begg's test)...
June 22, 2017: Pituitary
https://www.readbyqxmd.com/read/28637835/do-copd-subtypes-really-exist-copd-heterogeneity-and-clustering-in-10-independent-cohorts
#13
Peter J Castaldi, Marta Benet, Hans Petersen, Nicholas Rafaels, James Finigan, Matteo Paoletti, H Marike Boezen, Judith M Vonk, Russell Bowler, Massimo Pistolesi, Milo A Puhan, Josep Anto, Els Wauters, Diether Lambrechts, Wim Janssens, Francesca Bigazzi, Gianna Camiciottoli, Michael H Cho, Craig P Hersh, Kathleen Barnes, Stephen Rennard, Meher Preethi Boorgula, Jennifer Dy, Nadia N Hansel, James D Crapo, Yohannes Tesfaigzi, Alvar Agusti, Edwin K Silverman, Judith Garcia-Aymerich
BACKGROUND: COPD is a heterogeneous disease, but there is little consensus on specific definitions for COPD subtypes. Unsupervised clustering offers the promise of 'unbiased' data-driven assessment of COPD heterogeneity. Multiple groups have identified COPD subtypes using cluster analysis, but there has been no systematic assessment of the reproducibility of these subtypes. OBJECTIVE: We performed clustering analyses across 10 cohorts in North America and Europe in order to assess the reproducibility of (1) correlation patterns of key COPD-related clinical characteristics and (2) clustering results...
June 21, 2017: Thorax
https://www.readbyqxmd.com/read/28633688/normative-development-of-the-child-behavior-checklist-dysregulation-profile-from-early-childhood-to-adolescence-associations-with-personality-pathology
#14
Marike H F Deutz, Helen G M Vossen, Amaranta D De Haan, Maja Deković, Anneloes L Van Baar, Peter Prinzie
The Dysregulation Profile (DP) is a broad indicator of concurrent affective, behavioral, and cognitive dysregulation, often measured with the anxious/depressed, aggressive behavior, and attention problems syndrome scales of the Child Behavior Checklist. Despite an expanding body of research on the DP, knowledge of the normative developmental course of the DP from early childhood to adolescence is lacking. Furthermore, although we know that the DP longitudinally predicts personality pathology, no research yet has examined whether next to the DP in early childhood, the rate of change of the DP across development predicts personality pathology...
June 21, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28596295/genetic-variance-is-associated-with-susceptibility-for-cigarette-smoke-induced-damp-release-in-mice
#15
Simon D Pouwels, Alen Faiz, Lisette E den Boef, Reneé Gras, Maarten van den Berge, H Marike Boezen, Ron Korstanje, Nick H T Ten Hacken, Antoon J M van Oosterhout, Irene H Heijink, Martijn C Nawijn
Chronic obstructive pulmonary disease (COPD) is characterized by unresolved neutrophilic airway inflammation, and is caused by chronic exposure to toxic gases, such as cigarette smoke (CS), in genetically susceptible individuals. Recent data indicate a role for Damage Associated Molecular Patterns (DAMPs) in COPD. Here, we investigated the genetics of CS-induced DAMP release in 28 inbred mouse strains. Subsequently, in lung tissue from a subset of strains the expression of the identified candidate genes was analyzed...
June 8, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28583635/influence-of-pet-reconstruction-technique-and-matrix-size-on-qualitative-and-quantitative-assessment-of-lung-lesions-on-18f-fdg-pet-a-prospective-study-in-37-cancer-patients
#16
Georg Riegler, Georgios Karanikas, Ivo Rausch, Albert Hirtl, Karem El-Rabadi, Wolfgang Marik, Christopher Pivec, Michael Weber, Helmut Prosch, Marius Mayerhoefer
PURPOSE: To evaluate the influence of point spread function (PSF)-based reconstruction and matrix size for PET on (1) lung lesion detection and (2) standardized uptake values (SUV). METHODS: This prospective study included oncological patients who underwent [18F]-FDG-PET/CT for staging. PET data were reconstructed with a 2D ordered subset expectation maximization (OSEM) algorithm, and a 2D PSF-based algorithm (TrueX), separately with two matrix sizes (168×168 and 336×336)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28575402/factors-influencing-women-s-preferences-for-subsequent-management-in-the-event-of-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage
#17
Judith E K R Hentzen, Marianne A Verschoor, Marike Lemmers, Willem M Ankum, Ben Willem J Mol, Madelon van Wely
STUDY QUESTION: What affects women's treatment preferences in the management of an incomplete evacuation of the uterus after misoprostol treatment for a first-trimester miscarriage? SUMMARY ANSWER: Women's treatment preferences in the management of an incomplete evacuation of the uterus after misoprostol treatment for miscarriage are most strongly influenced by 'the risk of a reduced fertility' followed by 'the probability of success'. WHAT IS KNOWN ALREADY: Available treatment options in miscarriage are surgical, medical or expectant management...
May 31, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28556491/frequency-of-submicroscopic-chromosome-aberrations-in-pregnancies-without-increased-risk-for-structural-chromosome-aberrations-a-systematic-review-of-literature-and-meta-analysis
#18
REVIEW
Malgorzata I Srebniak, Marieke Joosten, Maarten F C M Knapen, Lidia R Arends, Marike Polak, Stefanie van Veen, Attie Go, Diane Van Opstal
OBJECTIVE: To establish the frequency of pathogenic submicroscopic chromosome aberrations in fetuses that are not at increased risk for unbalanced structural chromosome aberrations, a systematic literature search was performed. The aim was to determine whether high resolution testing for submicroscopic aberrations is beneficial in a general pregnant population. METHODS: On 3rd June 2016 Embase and PubMed databases were systematically searched for all relevant articles on prevalence of pathogenic submicroscopic CNVs in fetuses tested due to advanced maternal age or parental anxiety...
May 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28555425/ethical-considerations-of-neuro-oncology-trial-design-in-the-era-of-precision-medicine
#19
REVIEW
Saksham Gupta, Timothy R Smith, Marike L Broekman
The field of oncology is currently undergoing a paradigm shift. Advances in the understanding of tumor biology and in tumor sequencing technology have contributed to the shift towards precision medicine, the therapeutic framework of targeting the individual oncogenic changes each tumor harbors. The success of precision medicine therapies, such as targeted kinase inhibitors and immunotherapies, in other cancers have motivated studies in brain cancers. The high specificity and cost of these therapies also encourage a shift in clinical trial design away from randomized control trials towards smaller, more exclusive early phase clinical trials...
August 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28549273/body-weight-supported-bedside-treadmill-training-facilitates-ambulation-in-icu-patients-an-interventional-proof-of-concept-study
#20
Juultje Sommers, Denise C Wieferink, Dave A Dongelmans, Frans Nollet, Raoul H H Engelbert, Marike van der Schaaf
PURPOSE: Early mobilisation is advocated to improve recovery of intensive care unit (ICU) survivors. However, severe weakness in combination with tubes, lines and machinery are practical barriers for the implementation of ambulation with critically ill patients. The aim of this study was to explore the feasibility of Body Weight-Supported Treadmill Training (BWSTT) in critically ill patients in the ICU. METHODS: A custom build bedside Body Weight-Supported Treadmill was used and evaluated in medical and surgical patients in the ICU...
May 13, 2017: Journal of Critical Care
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