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https://www.readbyqxmd.com/read/27914867/new-hbm-values-for-emerging-substances-inventory-of-reference-and-hbm-values-in-force-and-working-principles-of-the-german-human-biomonitoring-commission
#1
REVIEW
Petra Apel, Jürgen Angerer, Michael Wilhelm, Marike Kolossa-Gehring
The German Human Biomonitoring Commission (HBM Commission) derives health-related guidance values (Human Biomonitoring assessment values, HBM values) according to the procedures described in the HBM Commission's position papers. Since the last adaption of the methodology in 2014, the HBM Commission has established a series of new HBM values, mainly on the basis of internationally agreed TDI/RfD values, or of toxicologically well- founded points of departure observed in animal studies. The derivation of these new HBM values for HBCDD, triclosan, 2-MBT, PFOA and PFOS as well as for the metabolites of glycol ethers, of Hexamoll(®) DINCH(®), DPHP, DEHTP, NMP, NEP, and 4-MBC is specified, and the HBM values are presented together with already established HBM values for other substances...
September 17, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27901017/daily-intake-and-hazard-index-of-parabens-based-upon-24%C3%A2-h-urine-samples-of-the-german-environmental-specimen-bank-from-1995-to-2012
#2
Rebecca K Moos, Petra Apel, Christa Schröter-Kermani, Marike Kolossa-Gehring, Thomas Brüning, Holger M Koch
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24 h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27878374/agents-for-fluorescence-guided-glioma-surgery-a-systematic-review-of-preclinical-and-clinical-results
#3
REVIEW
Joeky T Senders, Ivo S Muskens, Rosalie Schnoor, Aditya V Karhade, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Fluorescence-guided surgery (FGS) is a technique used to enhance visualization of tumor margins in order to increase the extent of tumor resection in glioma surgery. In this paper, we systematically review all clinically tested fluorescent agents for application in FGS for glioma and all preclinically tested agents with the potential for FGS for glioma. METHODS: We searched the PubMed and Embase databases for all potentially relevant studies through March 2016...
November 22, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27875750/how-children-s-victimization-relates-to-distorted-versus-sensitive-social-cognition-perception-mood-and-need-fulfillment-in-response-to-cyberball-inclusion-and-exclusion
#4
Tessa A M Lansu, Tirza H J van Noorden, Marike H F Deutz
This study examined whether victimization is associated with negatively distorted social cognition (bias), or with a specific increased sensitivity to social negative cues, by assessing the perception of social exclusion and the consequences for psychological well-being (moods and fundamental needs). Both self-reported and peer-reported victimization of 564 participants (Mage=9.9years, SD=1.04; 49.1% girls) were measured, and social exclusion was manipulated through inclusion versus exclusion in a virtual ball-tossing game (Cyberball)...
November 19, 2016: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/27865924/effects-of-a-coordinated-farmland-bird-conservation-project-on-farmers-intentions-to-implement-nature-conservation-practices-evidence-from-the-swedish-volunteer-farmer-alliance
#5
Jonas Josefsson, Anne Marike Lokhorst, Tomas Pärt, Åke Berg, Sönke Eggers
To increase the efficacy of agri-environmental schemes (AES), as well as farmers' environmental engagement, practitioners are increasingly turning to collective forms of agri-environmental management. As yet, empirical evidence from such approaches is relatively scarce. Here, we examined a farmland bird conservation project coordinated by BirdLife Sweden, the Swedish Volunteer & Farmer Alliance (SVFA). The key features of the SVFA were farmland bird inventories from volunteering birdwatchers and on-farm visits to individual farmers from conservation advisors for guidance on AES as well as unsubsidised practices...
November 17, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27865710/new-human-biomonitoring-methods-for-chemicals-of-concern-the-german-approach-to-enhance-relevance
#6
Marike Kolossa-Gehring, Ulrike Fiddicke, Gabriele Leng, Jürgen Angerer, Birgit Wolz
In Germany strong efforts have been made within the last years to develop new methods for human biomonitoring (HBM). The German Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) and the German Chemical Industry Association e. V. (VCI) cooperate since 2010 to increase the knowledge on the internal exposure of the general population to chemicals. The projects aim is to promote human biomonitoring by developing new analytical methods Key partner of the cooperation is the German Environment Agency (UBA) which has been entrusted with the scientific coordination...
November 10, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27864707/impact-of-operative-length-on-post-operative-complications-in-meningioma-surgery-a-nsqip-analysis
#7
Aditya V Karhade, Luis Fandino, Saksham Gupta, David J Cote, Julian B Iorgulescu, Marike L Broekman, Linda S Aglio, Ian F Dunn, Timothy R Smith
Many studies have implicated operative length as a predictor of post-operative complications, including venous thromboembolism [deep vein thrombosis (DVT) and pulmonary embolism (PE)]. We analyzed the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database from 2006 to 2014, to evaluate whether length of operation had a statistically significant effect on post-operative complications in patients undergoing surgical resection of meningioma. Patients were included for this study if they had a post-operative diagnosis of meningioma...
November 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27863804/phthalate-metabolites-in-24-h-urine-samples-of-the-german-environmental-specimen-bank-esb-from-1988-to-2015-and-a-comparison-with-us-nhanes-data-from-1999-to-2012
#8
Holger M Koch, Maria Rüther, André Schütze, André Conrad, Claudia Pälmke, Petra Apel, Thomas Brüning, Marike Kolossa-Gehring
The German Environmental Specimen Bank (ESB) continuously collects 24-h urine samples since the early 1980s in Germany. In this study we analyzed 300 urine samples from the years 2007 to 2015 for 21 phthalate metabolites (representing exposure to 11 parent phthalates) and combined the data with two previous retrospective measurement campaigns (1988 to 2003 and 2002 to 2008). The combined dataset comprised 1162 24-h urine samples spanning the years 1988 to 2015. With this detailed set of human biomonitoring data we describe the time course of phthalate exposure in Germany over a time frame of 27 years...
November 9, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27858374/prediction-of-fluid-responsiveness-an-update
#9
REVIEW
Xavier Monnet, Paul E Marik, Jean-Louis Teboul
In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion does not always increase cardiac output as one expects. Thus, after the very initial phase and/or if fluid losses are not obvious, predicting fluid responsiveness should be the first step of fluid strategy. For this purpose, the central venous pressure as well as other "static" markers of preload has been used for decades, but they are not reliable...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27850977/1341-fluid-administration-in-sepsis-septic-shock-patterns-and-outcomes-large-national-database-analysis
#10
Paul Marik, Edward Bittner, Douglas Hansell, Jennifer Sahatjian, Walter Linde-Zwirble
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845578/the-well-known-gene-hhip-and-novel-gene-mecr-are-implicated-in-small-airway-obstruction
#11
Diana A van der Plaat, Kim de Jong, Lies Lahousse, Alen Faiz, Judith M Vonk, Cleo C van Diemen, Ivana Nedeljkovic, Najaf Amin, Ma'en Obeidat, Cornelia M van Duijn, H Marike Boezen, Dirkje S Postma
No abstract text is available yet for this article.
November 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27829799/diversity-and-biogeographical-patterns-of-legumes-leguminosae-indigenous-to-southern-africa
#12
Marike Trytsman, Robert H Westfall, Philippus J J Breytenbach, Frikkie J Calitz, Abraham E van Wyk
The principal aim of this study was to establish biogeographical patterns in the legume flora of southern Africa so as to facilitate the selection of species with agricultural potential. Plant collection data from the National Herbarium, South Africa, were analysed to establish the diversity and areas covered by legumes (Leguminosae/Fabaceae) indigenous to South Africa, Lesotho and Swaziland. A total of 27,322 records from 1,619 quarter degree grid cells, representing 1,580 species, 122 genera and 24 tribes were included in the analyses...
2016: PhytoKeys
https://www.readbyqxmd.com/read/27829710/early-norepinephrine-decreases-fluid-and-ventilatory-requirements-in-pediatric-vasodilatory-septic-shock
#13
Suchitra Ranjit, Rajeswari Natraj, Sathish Kumar Kandath, Niranjan Kissoon, Balasubramaniam Ramakrishnan, Paul E Marik
AIMS: We previously reported that vasodilatation was common in pediatric septic shock, regardless of whether they were warm or cold, providing a rationale for early norepinephrine (NE) to increase venous return (VR) and arterial tone. Our primary aim was to evaluate the effect of smaller fluid bolus plus early-NE versus the American College of Critical Care Medicine (ACCM) approach to more liberal fluid boluses and vasoactive-inotropic agents on fluid balance, shock resolution, ventilator support and mortality in children with septic shock...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27823879/new-approach-of-delivering-cytotoxic-drugs-towards-caix-expressing-cells-a-concept-of-dual-target-drugs
#14
Simon J A van Kuijk, Nanda Kumar Parvathaneni, Raymon Niemans, Marike W van Gisbergen, Fabrizio Carta, Daniela Vullo, Silvia Pastorekova, Ala Yaromina, Claudiu T Supuran, Ludwig J Dubois, Jean-Yves Winum, Philippe Lambin
Carbonic anhydrase IX (CAIX) is a hypoxia-regulated and tumor-specific protein that maintains the pH balance of cells. Targeting CAIX might be a valuable approach for specific delivery of cytotoxic drugs, thereby reducing normal tissue side-effects. A series of dual-target compounds were designed and synthesized incorporating a sulfonamide, sulfamide, or sulfamate moiety combined with several different anti-cancer drugs, including the chemotherapeutic agents chlorambucil, tirapazamine, and temozolomide, two Ataxia Telangiectasia and Rad3-related protein inhibitors (ATRi), and the anti-diabetic biguanide agent phenformin...
October 19, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27812378/the-clinical-characteristics-and-hospital-and-post-hospital-survival-of-patients-with-the-obesity-hypoventilation-syndrome-analysis-of-a-large-cohort
#15
P E Marik, C Chen
OBJECTIVE: The worldwide prevalence of obesity has reached epidemic proportions. Obesity hypoventilation syndrome (OHS) is a common yet largely undiagnosed and mistreated condition that likely carries a high mortality. The aim of this study was to determine the clinical characteristics, hospital outcome, outcome following hospital discharge and predictors of death in a large cohort of patients hospitalized with OHS. OHS is an important condition as many patients with this syndrome are misdiagnosed and receive inappropriate treatment...
March 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27803349/dr-koeckhoven-et-al-reply
#16
Esmee Koeckhoven, Marike VAN DER Leeden, Leo D Roorda, Natasja M VAN Schoor, Paul Lips, Arjan DE Zwart, Joost Dekker, Martin VAN DER Esch, Willem F Lems
No abstract text is available yet for this article.
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27760836/preclinical-efficacy-of-an-antibody-drug-conjugate-targeting-mesothelin-correlates-with-quantitative-89zr-immunopet
#17
Anton G T Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander Vanderbilt, Jeff Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suzie J Scales, Simon-Peter Williams
Antibody-drug conjugates (ADCs) use monoclonal antibodies (mAb) as vehicles to deliver potent cytotoxic drugs selectively to tumor cells expressing the target. Molecular imaging with zirconium-89 (89Zr) labeled mAbs recapitulates similar targeting biology and might help predict the efficacy of these ADCs. An anti-mesothelin antibody (AMA, MMOT0530A) was used to make comparisons between its efficacy as an ADC and its tumor uptake as measured by 89Zr immunoPET imaging. Mesothelin-targeted tumor growth inhibition by monomethyl auristatin E (MMAE), ADC AMA-MMAE (DMOT4039A), was measured in mice bearing xenografts of ovarian cancer OVCAR-3 X2...
October 19, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27738901/the-history-of-head-transplantation-a-review
#18
REVIEW
Nayan Lamba, Daniel Holsgrove, Marike L Broekman
BACKGROUND: Since the turn of the last century, the prospect of head transplantation has captured the imagination of scientists and the general public. Recently, head transplant has regained attention in popular media, as neurosurgeons have proposed performing this procedure in 2017. Given the potential impact of such a procedure, we were interested in learning the history of the technical hurdles that need to be overcome, and determine if it is even technically possible to perform such a procedure on humans today...
December 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27720143/sodium-and-potassium-intake-in-south-africa-an-evaluation-of-24-hour-urine-collections-in-a-white-black-and-indian-population
#19
Bianca Swanepoel, Aletta E Schutte, Marike Cockeran, Krisela Steyn, Edelweiss Wentzel-Viljoen
Limited number of studies on salt intake has been conducted in the South Africa. The present study established the sodium and potassium excretion (24-hour urine collection) of three different South African populations. In total, 692 successful 24-hour urine collections were analyzed for sodium, potassium, and iodine levels. The median sodium and potassium excretion was 122.9 and 33.5 mmol/d, respectively, and the median salt intake was 7.2 g/d. The majority (92.8%) of the population did not meet the recommended potassium intake/d, and 65...
September 6, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27680301/a-standardized-method-to-determine-the-concentration-of-extracellular-vesicles-using-tunable-resistive-pulse-sensing
#20
Robert Vogel, Frank A W Coumans, Raluca G Maltesen, Anita N Böing, Katherine E Bonnington, Marike L Broekman, Murray F Broom, Edit I Buzás, Gunna Christiansen, Najat Hajji, Søren R Kristensen, Meta J Kuehn, Sigrid M Lund, Sybren L N Maas, Rienk Nieuwland, Xabier Osteikoetxea, Rosalie Schnoor, Benjamin J Scicluna, Mitch Shambrook, Jeroen de Vrij, Stephen I Mann, Andrew F Hill, Shona Pedersen
BACKGROUND: Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on in-depth quantification, measurement and identification of EV sub-populations. Quantification of EVs has presented several challenges, predominantly due to the small size of vesicles such as exosomes and the availability of various technologies to measure nanosized particles, each technology having its own limitations. MATERIALS AND METHODS: A standardized methodology to measure the concentration of extracellular vesicles (EVs) has been developed and tested...
2016: Journal of Extracellular Vesicles
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