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Anton G T Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander Vanderbilt, Jeff Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suzie J Scales, Simon-Peter Williams
Antibody-drug conjugates (ADCs) use monoclonal antibodies (mAb) as vehicles to deliver potent cytotoxic drugs selectively to tumor cells expressing the target. Molecular imaging with zirconium-89 (89Zr) labeled mAbs recapitulates similar targeting biology and might help predict the efficacy of these ADCs. An anti-mesothelin antibody (AMA, MMOT0530A) was used to make comparisons between its efficacy as an ADC and its tumor uptake as measured by 89Zr immunoPET imaging. Mesothelin-targeted tumor growth inhibition by monomethyl auristatin E (MMAE), ADC AMA-MMAE (DMOT4039A), was measured in mice bearing xenografts of ovarian cancer OVCAR-3 X2...
October 19, 2016: Molecular Cancer Therapeutics
Nayan Lamba, Daniel Holsgrove, Marike L Broekman
BACKGROUND: Since the turn of the last century, the prospect of head transplantation has captured the imagination of scientists and the general public. Recently, head transplant has regained attention in popular media, as neurosurgeons have proposed performing this procedure in 2017. Given the potential impact of such a procedure, we were interested in learning the history of the technical hurdles that need to be overcome, and determine if it is even technically possible to perform such a procedure on humans today...
October 14, 2016: Acta Neurochirurgica
Bianca Swanepoel, Aletta E Schutte, Marike Cockeran, Krisela Steyn, Edelweiss Wentzel-Viljoen
Limited number of studies on salt intake has been conducted in the South Africa. The present study established the sodium and potassium excretion (24-hour urine collection) of three different South African populations. In total, 692 successful 24-hour urine collections were analyzed for sodium, potassium, and iodine levels. The median sodium and potassium excretion was 122.9 and 33.5 mmol/d, respectively, and the median salt intake was 7.2 g/d. The majority (92.8%) of the population did not meet the recommended potassium intake/d, and 65...
September 6, 2016: Journal of the American Society of Hypertension: JASH
Robert Vogel, Frank A W Coumans, Raluca G Maltesen, Anita N Böing, Katherine E Bonnington, Marike L Broekman, Murray F Broom, Edit I Buzás, Gunna Christiansen, Najat Hajji, Søren R Kristensen, Meta J Kuehn, Sigrid M Lund, Sybren L N Maas, Rienk Nieuwland, Xabier Osteikoetxea, Rosalie Schnoor, Benjamin J Scicluna, Mitch Shambrook, Jeroen de Vrij, Stephen I Mann, Andrew F Hill, Shona Pedersen
BACKGROUND: Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on in-depth quantification, measurement and identification of EV sub-populations. Quantification of EVs has presented several challenges, predominantly due to the small size of vesicles such as exosomes and the availability of various technologies to measure nanosized particles, each technology having its own limitations. MATERIALS AND METHODS: A standardized methodology to measure the concentration of extracellular vesicles (EVs) has been developed and tested...
2016: Journal of Extracellular Vesicles
Abel Makubi, Bruno P Mmbando, Enrico M Novelli, Johnson Lwakatare, Deogratius Soka, Harvest Marik, Kemi Tibarazwa, Mariam Ngaeje, Charles R Newton, Mark T Gladwin, Julie Makani
Data on the magnitude and risk factors for hypertension in sickle cell anaemia (SCA) are limited. A retrospective analysis of individuals with SCA aged ≥15 years enrolled from 2004-2014 at Muhimbili National Hospital, Tanzania was conducted to determine the prevalence, incidence and risk factors for hypertension. A total of 1013 individuals with SCA were analysed, of whom 571(56%) were females. The median age [interquartile range] was 17 [15-22] years. Four hundred and forty-one (44%) of the patients had relative hypertension [systolic blood pressure (SBP) 120-139 mmHg or diastolic blood pressure (DBP) 70-89 mmHg], and 79 (8%) had hypertension (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg)...
September 21, 2016: British Journal of Haematology
Martin van der Esch, Marike van der Leeden, Leo D Roorda, Willem F Lems, Joost Dekker
The aims of the study were to (i) determine the prevalence and course of self-reported knee instability at 2-year follow-up and (ii) identify factors predictive of retention of self-reported knee instability among patients with established knee osteoarthritis (OA). Among 201 patients from the Amsterdam Osteoarthritis (AMS-OA) cohort, demographic characteristics, self-reported knee instability, muscle strength, proprioception, pain, and physical function were assessed at baseline and at 2 years. Exercise over the past 2 years was assessed by evaluating the medical files...
September 17, 2016: Clinical Rheumatology
Paul E Marik
No abstract text is available yet for this article.
October 2016: Critical Care Medicine
Jeanine Kamphuis, Swetlana Baichel, Marike Lancel, Sietse F de Boer, Jaap M Koolhaas, Peter Meerlo
Sleep deprivation has profound effects on cognitive performance, and some of these effects may be mediated by impaired prefrontal cortex function. In search of an animal model to investigate this relationship we studied the influence of restricted sleep on operant conditioning in rats, particularly the performance in a differential reinforcement of low rate responding (DRL) task, which is highly dependent upon an intact prefrontal cortex. Animals were trained to withhold a lever press until an imposed delay of 30 s after the last press had passed in order to achieve a food reward...
September 16, 2016: Journal of Sleep Research
Marlene J Sandstrom, Marike H F Deutz, Tessa A M Lansu, Tirza H J van Noorden, Johan C Karremans, Antonius H N Cillessen
Previous research has shown that ostracism-the experience of being ignored and excluded-has negative effects on all of us, young and old. Using a Cyberball paradigm, the present research replicates the effects of ostracism on the moods (anger, anxiety, happiness, and anger) and fundamental needs (belongingness, control, meaningful existence, and self-esteem) of children (Study 1) and then extends the literature by examining the role of the number of ostracizers and inclusive members in this process by randomly assigning children to conditions varying in degree of ostracism (Study 2)...
September 14, 2016: Aggressive Behavior
Kim de Jong, Judith M Vonk, Alen Faiz, Diana A van der Plaat, Wim Timens, Yohan Bossé, Hans Kromhout, Ivana Nedeljkovic, Dirkje S Postma, H Marike Boezen
No abstract text is available yet for this article.
September 15, 2016: American Journal of Respiratory and Critical Care Medicine
Ima Trempler, Anne-Marike Schiffer, Nadiya El-Sourani, Christiane Ahlheim, Gereon R Fink, Ricarda I Schubotz
Surprising events may be relevant or irrelevant for behavior, requiring either flexible adjustment or stabilization of our model of the world and according response strategies. Cognitive flexibility and stability in response to environmental demands have been described as separable cognitive states, associated with activity of striatal and lateral prefrontal regions, respectively. It so far remains unclear, however, whether these two states act in an antagonistic fashion and which neural mechanisms mediate the selection of respective responses, on the one hand, and a transition between these states, on the other...
September 14, 2016: Journal of Cognitive Neuroscience
Sourav Marik, Madhu Chennabasappa, Javier Fernández-Sanjulián, Emmanuel Petit, Olivier Toulemonde
A study of the structure-composition-properties correlation is reported for the oxygen-deficient SrFe1-xCoxO2.75-δ (x = 0.1-0.85) materials. The introduction of Co in the parent SrFeO2.75 (Sr4Fe4O11) structure revealed an interesting structural transformation. At room temperature (RT), an orthorhombic (space group Cmmm, 2√2ap × 2ap × √2ap type, ap = lattice parameter of the cubic perovskite) → tetragonal (space group P4/mmm, ap × ap × 2ap type) → tetragonal (space group I4/mmm, 2ap × 2ap × 4ap type) structural transformation is observed in parallel with increasing Co content and decreasing oxygen content in the structure...
October 3, 2016: Inorganic Chemistry
Diana A van der Plaat, Kim de Jong, Lies Lahousse, Alen Faiz, Judith M Vonk, Cleo C van Diemen, Ivana Nedeljkovic, Najaf Amin, Guy G Brusselle, Albert Hofman, Corry-Anke Brandsma, Yohan Bossé, Don D Sin, David C Nickle, Cornelia M van Duijn, Dirkje S Postma, H Marike Boezen
BACKGROUND: Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility studies have not focused on this group exclusively. OBJECTIVE: The aim of this study was to identify common genetic variants associated with FEV1 and its ratio to forced vital capacity (FVC) in never-smokers. METHODS: Genome-wide association studies were performed in 5070 never-smokers of the identification cohort LifeLines, and results (P < 10(-5)) were verified by using a meta-analysis of the Vlagtwedde-Vlaardingen study and the Rotterdam Study I-III (total n = 1966)...
September 6, 2016: Journal of Allergy and Clinical Immunology
Leonie van Meer, Matthijs Moerland, Marloes van Dongen, Bas Goulouze, Marieke de Kam, Erica Klaassen, Adam Cohen, Jacobus Burggraaf
ISIS 388626 is an antisense sodium-glucose cotransporter 2 (SGLT2) inhibitor designed to treat type 2 diabetes mellitus by induction of glucosuria. ISIS 388626 was demonstrated to be safe and effective in preclinical trails in several species. We undertook the present study to evaluate the safety and efficacy of 13 weekly doses of 50, 100, and 200 mg of ISIS 388626 in humans. ISIS 388626 increased 24-hour urinary glucose excretion dose dependently with 508.9 ± 781.45 mg/day in the 100-mg and 1299.8 ± 1833...
November 2016: Journal of Pharmacology and Experimental Therapeutics
Anne-Marike Schiffer, Kayla Siletti, Florian Waszak, Nick Yeung
In any non-deterministic environment, unexpected events can indicate true changes in the world (and require behavioural adaptation) or reflect chance occurrence (and must be discounted). Adaptive behaviour requires distinguishing these possibilities. We investigated how humans achieve this by integrating high-level information from instruction and experience. In a series of EEG experiments, instructions modulated the perceived informativeness of feedback: Participants performed a novel probabilistic reinforcement learning task, receiving instructions about reliability of feedback or volatility of the environment...
August 27, 2016: NeuroImage
Mariëtte de Rooij, Marike van der Leeden, John Cheung, Martin van der Esch, Arja Häkkinen, Daniël Haverkamp, Leo D Roorda, Jos Twisk, Joke Vollebregt, Willem F Lems, Joost Dekker
OBJECTIVE: To evaluate the efficacy on physical functioning and safety of tailored exercise therapy in patients with knee osteoarthritis (KOA) and comorbidities. METHOD: In a randomized controlled trial, 126 participants were included with a clinical diagnosis of KOA and at least one of the following target comorbidities: coronary disease, heart failure, type 2 diabetes, chronic obstructive pulmonary disease or obesity (body mass index≥ 30kg/m(2) ), with severity score ≥2 on the Cumulative Illness Rating Scale...
August 26, 2016: Arthritis Care & Research
Lisa D M Verberne, Marike R C Hendriks, Geert M Rutten, Inge Spronk, Hans H C M Savelberg, Cindy Veenhof, Mark M J Nielen
BACKGROUND: Combined lifestyle interventions (CLIs) are designed to reduce risk factors for lifestyle-related diseases through increasing physical activity and improvement of dietary behaviour. OBJECTIVE: To evaluate the effects of a CLI for overweight and obese patients on lifestyle-related risk factors and health care consumption, in comparison to usual care. METHODS: Data on anthropometric and metabolic measurements, morbidity, drugs prescriptions and general practitioner (GP) consultations were extracted from electronic health records (timeframe: July 2009-August 2013)...
August 18, 2016: Family Practice
Ananya Marik, Haraprasad Naiya, Madhumanti Das, Gairik Mukherjee, Soumalee Basu, Chinmay Saha, Rajdeep Chowdhury, Kankan Bhattacharyya, Anindita Seal
Natural resistance associated macrophage proteins (NRAMPs) are evolutionarily conserved metal transporters involved in the transport of essential and nonessential metals in plants. Fifty protein interactors of a Brassica juncea NRAMP protein was identified by a Split-Ubiquitin Yeast-Two-Hybrid screen. The interactors were predicted to function as components of stress response, signaling, development, RNA binding and processing. BjNRAMP4.1 interactors were particularly enriched in proteins taking part in photosynthetic or light regulated processes, or proteins predicted to be localized in plastid/chloroplast...
August 17, 2016: Plant Molecular Biology
Marike L Broekman, Saskia Peerdeman
No abstract text is available yet for this article.
October 2016: Acta Neurochirurgica
Maartje A Nieuwenhuis, Matteusz Siedlinski, Maarten van den Berge, Raquel Granell, Xingnan Li, Marijke Niens, Pieter van der Vlies, Janine Altmüller, Peter Nürnberg, Marjan Kerkhof, Onno C van Schayck, Ronald A Riemersma, Thys van der Molen, Jan G de Monchy, Yohan Bossé, Andrew Sandford, Carla A Bruijnzeel-Koomen, Roy G van Wijk, Nick H Ten Hacken, Wim Timens, H Marike Boezen, John Henderson, Michael Kabesch, Judith M Vonk, Dirkje S Postma, Gerard H Koppelman
BACKGROUND: Genome wide association studies (GWAS) of asthma have identified single nucleotide polymorphisms (SNPs) that modestly increase the risk for asthma. This could be due to phenotypic heterogeneity of asthma. Bronchial hyperresponsiveness (BHR) is a phenotypic hallmark of asthma. We aim to identify susceptibility genes for asthma combined with BHR and analyse the presence of cis-eQTLs among replicated SNPs. Secondly, we compare the genetic association of SNPs previously associated with (doctor diagnosed) asthma to our GWAS of asthma with BHR...
July 20, 2016: Allergy
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