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https://www.readbyqxmd.com/read/28319014/human-biomonitoring-science-and-policy-for-a-healthy-future-april-17-19-2016-berlin-germany
#1
Joas Anke, Gerda Schwedler, Judy Choi, Marike Kolossa-Gehring
Following the success of the 1st International Conference on Human Biomonitoring (HBM) in Berlin in 2010, the 2nd International Conference on Human Biomonitoring took place in Berlin from April 17-19, 2016 for an exchange and updates among participants on all aspects relating to HBM. Entitled "Science and Policy for a Healthy Future", the conference brought together international experts from the scientific sector, politics, authorities, industry, non-governmental organizations (NGOs), and other involved associations...
February 7, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28301864/functional-recovery-in-patients-with-and-without-intensive-care-unit-acquired-weakness
#2
Daniela Susanne Dettling-Ihnenfeldt, Luuk Wieske, Janneke Horn, Frans Nollet, Marike van der Schaaf
OBJECTIVE: The aim of this work was to compare the patient-reported functional health status with regard to physical, psychological, and social functioning of intensive care unit (ICU) survivors with and without ICU-acquired weakness (ICU-AW). DESIGN: Single-center prospective study in ICU patients who were mechanically ventilated for more than 2 days and who survived to ICU discharge. Functional health status was assessed at 3, 6, and 12 months after ICU discharge, using the Sickness Impact Profile 68 (SIP68)...
April 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28291035/borderline-or-schizotypal-differential-psychodynamic-assessment-in-severe-personality-disorders
#3
Laura VAN Riel, Theo J M Ingenhoven, Quin D VAN Dam, Marike G Polak, Meinte G Vollema, Anne E Willems, Han Berghuis, Harold VAN Megen
Considerable overlap in symptoms between patients with borderline personality disorder (BPD) and schizotypal personality disorder (STPD) complicates personality diagnostics. Yet very little is known about the level of psychodynamic functioning of both personality disorders. Psychodynamic assessment procedures may specify personality characteristics relevant for differential diagnosis and treatment planning. In this cross-sectional study we explored the differences and similarities in level of personality functioning and psychodynamic features of patients with severe BPD or STPD...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28287158/structural-reorganization-of-the-fungal-endoplasmic-reticulum-upon-induction-of-mycotoxin-biosynthesis
#4
Marike Johanne Boenisch, Karen Lisa Broz, Samuel Owen Purvine, William Byron Chrisler, Carrie Diana Nicora, Lanelle Reine Connolly, Michael Freitag, Scott Edward Baker, Harold Corby Kistler
Compartmentalization of metabolic pathways to particular organelles is a hallmark of eukaryotic cells. Knowledge of the development of organelles and attendant pathways under different metabolic states has been advanced by live cell imaging and organelle specific analysis. Nevertheless, relatively few studies have addressed the cellular localization of pathways for synthesis of fungal secondary metabolites, despite their importance as bioactive compounds with significance to medicine and agriculture. When triggered to produce sesquiterpene (trichothecene) mycotoxins, the endoplasmic reticulum (ER) of the phytopathogenic fungus Fusarium graminearum is reorganized both in vitro and in planta...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286969/involving-people-with-dementia-in-developing-an-interactive-web-tool-for-shared-decision-making-experiences-with-a-participatory-design-approach
#5
Marijke Span, Marike Hettinga, Leontine Groen-van de Ven, Jan Jukema, Ruud Janssen, Myrra Vernooij-Dassen, Jan Eefsting, Carolien Smits
PURPOSE: The aim of this study was at gaining insight into the participatory design approach of involving people with dementia in the development of the DecideGuide, an interactive web tool facilitating shared decision-making in their care networks. METHOD: An explanatory case study design was used when developing the DecideGuide. A secondary analysis focused on the data gathered from the participating people with dementia during the development stages: semi-structured interviews (n = 23), four focus group interviews (n = 18), usability tests (n = 3), and a field study (n = 4)...
March 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28284775/human-biomonitoring-as-a-tool-to-support-chemicals-regulation-in-the-european-union
#6
Catherine Ganzleben, Jean-Philippe Antignac, Robert Barouki, Argelia Castaño, Ulrike Fiddicke, Jana Klánová, Erik Lebret, Nicolas Olea, Dimosthenis Sarigiannis, Greet R Schoeters, Ovnair Sepai, Hanna Tolonen, Marike Kolossa-Gehring
No abstract text is available yet for this article.
February 22, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28279778/readmission-and-other-adverse-events-after-transsphenoidal-surgery-prevalence-timing-and-predictive-factors
#7
David J Cote, Hormuz H Dasenbrock, Ivo S Muskens, Marike Ld Broekman, Hasan A Zaidi, Ian F Dunn, Timothy R Smith, Edward R Laws
BACKGROUND: Transsphenoidal surgery is a common neurosurgical procedure for accessing the pituitary and anterior skull base, yet few multicenter analyses have evaluated outcomes after this procedure. STUDY DESIGN: Patients undergoing transsphenoidal surgery from 2006 to 2015 were extracted from the ACS NSQIP database. Logistic regression was used to identify predictors of thirty-day complications. RESULTS: Of 1240 patients included in this analysis; 6...
March 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28273074/a-rare-il33-loss-of-function-mutation-reduces-blood-eosinophil-counts-and-protects-from-asthma
#8
Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T Magnusson, Gudmundur I Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A Deichmann, Gerard H Koppelman, Klaus Bønnelykke, Hans Bisgaard, Gisli Masson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, James A Johnston, Ingileif Jonsdottir, Kari Stefansson
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. Through whole-genome sequencing and imputation into the Icelandic population, we found a rare variant in IL33 (NM_001199640:exon7:c.487-1G>C (rs146597587-C), allele frequency = 0.65%) that disrupts a canonical splice acceptor site before the last coding exon...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28261948/diversity-profile-and-dynamics-of-peptaibols-produced-by-green-mould-trichoderma-species-in-interactions-with-their-hosts-agaricus-bisporus-and-pleurotus-ostreatus
#9
Tamás Marik, Péter Urbán, Chetna Tyagi, András Szekeres, Balázs Leitgeb, Máté Vágvölgyi, László Manczinger, Irina S Druzhinina, Csaba Vágvölgyi, László Kredics
Certain Trichoderma species are causing serious losses in mushroom production worldwide. Trichoderma aggressivum and Trichoderma pleuroti are among the major causal agents of the green mould diseases affecting Agaricus bisporus and Pleurotus ostreatus, respectively. The genus Trichoderma is well known for the production of bioactive secondary metabolites, including peptaibols, which are short, linear peptides containing unusual amino acid residues and being synthesised via non-ribosomal peptide synthetases (NRPSs)...
March 6, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28261062/mitochondrial-neurogastrointestinal-encephalomyopathy-caused-by-thymidine-phosphorylase-enzyme-deficiency-from-pathogenesis-to-emerging-therapeutic-options
#10
REVIEW
Rana Yadak, Peter Sillevis Smitt, Marike W van Gisbergen, Niek P van Til, Irenaeus F M de Coo
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a progressive metabolic disorder caused by thymidine phosphorylase (TP) enzyme deficiency. The lack of TP results in systemic accumulation of deoxyribonucleosides thymidine (dThd) and deoxyuridine (dUrd). In these patients, clinical features include mental regression, ophthalmoplegia, and fatal gastrointestinal complications. The accumulation of nucleosides also causes imbalances in mitochondrial DNA (mtDNA) deoxyribonucleoside triphosphates (dNTPs), which may play a direct or indirect role in the mtDNA depletion/deletion abnormalities, although the exact underlying mechanism remains unknown...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28255640/phylogenomic-resolution-of-the-bacterial-genus-pantoea-and-its-relationship-with-erwinia-and-tatumella
#11
Marike Palmer, Emma T Steenkamp, Martin P A Coetzee, Wai-Yin Chan, Elritha van Zyl, Pieter De Maayer, Teresa A Coutinho, Jochen Blom, Theo H M Smits, Brion Duffy, Stephanus N Venter
Investigation of the evolutionary relationships between related bacterial species and genera with a variety of lifestyles have gained popularity in recent years. For analysing the evolution of specific traits, however, a robust phylogeny is essential. In this study we examined the evolutionary relationships among the closely related genera Erwinia, Tatumella and Pantoea, and also attempted to resolve the species relationships within Pantoea. To accomplish this, we used the whole genome sequence data for 35 different strains belonging to these three genera, as well as nine outgroup taxa...
March 2, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28254163/human-biomonitoring-pilot-study-democophes-in-germany-contribution-to-a-harmonized-european-approach
#12
Gerda Schwedler, Margarete Seiwert, Ulrike Fiddicke, Sissy Ißleb, Jürgen Hölzer, Julia Nendza, Michael Wilhelm, Jürgen Wittsiepe, Holger M Koch, Birgit K Schindler, Thomas Göen, Jörg Hildebrand, Reinhard Joas, Anke Joas, Ludwine Casteleyn, Jürgen Angerer, Argelia Castano, Marta Esteban, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Louis Bloemen, Lisbeth E Knudsen, Marike Kolossa-Gehring
Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries. In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6-11year old children and their mothers in an urban and a rural region...
February 6, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28248150/feeding-the-critically-ill-more-questions-than-answers
#13
Paul E Marik, Todd W Rice
No abstract text is available yet for this article.
March 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28215426/the-impact-of-transsphenoidal-surgery-on-neurocognitive-function-a-systematic-review
#14
REVIEW
Adnan Alsumali, David J Cote, Quentin R Regestein, Erin Crocker, Abdulaziz Alzarea, Hasan A Zaidi, Wenya Linda Bi, Hassan Y Dawood, Marike L Broekman, Martine J E van Zandvoort, Rania A Mekary, Timothy R Smith
BACKGROUND: Cognitive impairment following transsphenoidal surgery (TSS) among patients with pituitary tumors has been intermittently reported and is not well established. We performed a systematic review to summarize the impact of TSS on cognitive function. METHODS: We conducted a systematic search of the literature using the PubMed, Cochrane, and Embase databases through October 2014. Studies were selected if they reported cognitive status after surgery and included at least 10 adult patients with pituitary tumors undergoing either endoscopic or microscopic TSS...
February 15, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28212240/the-author-replies
#15
Paul E Marik
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28209537/misorest-surgical-versus-expectant-management-in-women-with-an-incomplete-evacuation-of-the-uterus-after-misoprostol-treatment-for-miscarriage-a-cohort-study
#16
Marike Lemmers, Marianne A C Verschoor, Katrien Oude Rengerink, Christiana Naaktgeboren, Patrick M Bossuyt, Judith A F Huirne, Ineke A H Janssen, Celine Radder, Ellen R Klinkert, Josje Langenveld, Lucet van der Voet, F Frederike Siemens, Marlies Y Bongers, Marcel H van Hooff, Marinus van der Ploeg, F P J Sjors, S F P J Coppus, W M Ankum, Ben Willem J Mol
OBJECTIVE: To assess the effectiveness of curettage versus expectant management in women with an incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage. STUDY DESIGN: We conducted a multicenter cohort study alongside a randomized clinical trial (RCT) between June 2012 until July 2014. 27 Dutch hospitals participated. Women with an incomplete evacuation after misoprostol treatment for first trimester miscarriage who declined to participate in the RCT, received treatment of their preference; curettage (n=65) or expectant management (n=132)...
January 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28195519/troponin-t-release-is-associated-with-silent-myocardial-ischaemia-in-black-men-the-sabpa-study
#17
Madelein E Griffiths, Leoné Malan, Rhena Delport, Marike Cockeran, Manja Reimann
Background High sensitivity cardiac troponin T (hs-cTnT) is a validated marker of myocardial damage and may reflect the degree of silent myocardial ischaemia (SMI) and ventricular strain. Our aim was to compare hs-cTnT levels in black and white South Africans taking SMI into consideration. We further explored the capability of hs-cTnT to predict the presence of compensatory systolic hypertension in this South African cohort. Methods A bi-ethnic sex cohort ( n = 404) with similar socioeconomic status (198 black participants and 206 white participants, aged 20-65 years) participated in this target population study where 24 h ambulatory blood pressure, electrocardiogram and overnight fasting cardiometabolic variables were measured...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28180256/cohort-profile-the-karolinska-mammography-project-for-risk-prediction-of-breast-cancer-karma
#18
Marike Gabrielson, Mikael Eriksson, Mattias Hammarström, Signe Borgquist, Karin Leifland, Kamila Czene, Per Hall
No abstract text is available yet for this article.
February 9, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28172665/p279-children-born-to-mothers-with-inflammatory-bowel-disease-is-there-any-risk-for-newborns-complication-and-development-during-the-childhood
#19
K Farkas, K Szántό, N Vass, D Szűcs, A Demcsák, S Lada, T Nyári, A Milassin, M Rutka, R Bor, A Bálint, A Fábián, F Nagy, Z Szepes, A Marik, T Molnár
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167401/an-extended-theory-of-planned-behavior-to-predict-consumers-willingness-to-buy-mobile-slaughter-unit-meat
#20
Djura L Hoeksma, Marien A Gerritzen, Anne Marike Lokhorst, P Marijn Poortvliet
The current study investigated the determinants of consumers' intention to purchase meat from mobile slaughter units (MSU). The theory of planned behavior (TPB) and the value belief norm theory (VBN) were used as conceptual lenses to guide this investigation. We conducted a survey among 329 respondents in the Netherlands who buy meat for themselves and/or for others. The results indicated that (1) TPB and VBN explain a high proportion of the variance in consumers' intention to buy MSU meat, and that (2) an extended TPB that includes peoples' attitude, personal norm, subjective norm, and perceived behavioral control turned out to be the best model to predict willingness to buy MSU meat...
February 1, 2017: Meat Science
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