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https://www.readbyqxmd.com/read/29667849/defensive-coping-facilitated-a-smaller-cortisol-to-estradiol-ratio-and-a-higher-hypertension-risk-the-sabpa-study
#1
Leoné Malan, Andrea de Kock, Mark Hamer, Marike Cockeran, Nicolaas Theodor Malan
OBJECTIVES: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1 -adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1 -adrenergic responsiveness and hypertension risk when habitually using defensive coping. METHODS: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included...
April 18, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29656387/a-nationwide-analysis-of-30-day-adverse-events-unplanned-readmission-and-length-of-hospital-stay-after-peripheral-nerve-surgery-in-extremities-and-the-brachial-plexus
#2
Enrico Martin, Ivo S Muskens, Joeky T Senders, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Little is known on adverse events and their timing after peripheral nerve surgery in extremities. The aim of this study is to identify predictors and typical timing of complications, unplanned readmission, and length of hospital stay for patients undergoing peripheral nerve surgery in the extremities. METHODS: Data were extracted from the National Surgical Quality Improvement Program (NSQIP) registry from 2005 to 2015. Adult patients undergoing peripheral nerve surgery in the extremities were included...
April 15, 2018: Microsurgery
https://www.readbyqxmd.com/read/29655470/techniques-for-monitoring-drug-efficacy
#3
REVIEW
Marike Visser
The efficacy of drugs can vary greatly between species and individuals. Establishing efficacious drug doses for a species requires integration of population pharmacokinetic and pharmacodynamic data into a dose-response curve. Unfortunately, these data sets are rarely available for exotic species. The use of alternative monitoring techniques is required to determine drug efficacy and safety. This article discusses methods to integrate efficacy monitoring into clinical practice, including the use of diagnostic testing and therapeutic drug monitoring...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29655466/the-educated-guess-determining-drug-doses-in-exotic-animals-using-evidence-based-medicine
#4
REVIEW
Marike Visser, Seth C Oster
Lack of species-specific pharmacokinetic and pharmacodynamic data is a challenge for pharmaceutical and dose selection. If available, dose extrapolation can be accomplished via basic equations. If unavailable, several methods have been described. Linear scaling uses an established milligrams per kilograms dose based on weight. This does not allow for differences in species drug metabolism, sometimes resulting in toxicity. Allometric scaling correlates body weight and metabolic rate but fails for drugs with significant hepatic metabolism and cannot be extrapolated to avians or reptiles...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29655465/translating-pharmacokinetic-and-pharmacodynamic-data-into-practice
#5
REVIEW
Marike Visser
Pharmacokinetic (PK) and pharmacodynamic (PD) publications provide scientific evidence for incorporation in evidence-based veterinary medicine, aiding the clinician in selecting doses and dosing intervals. PK and PD studies have reported wide variations within exotic species, due to physiologic differences in absorption, distribution, metabolism, and excretion. PK studies offer species-specific data to help tailor doses and dosing routes to individual patients, minimize toxicity, and provide a cornerstone for PD studies to determine drug efficacy...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29618601/promoting-respiratory-public-health-through-epigenetics-research-an-ers-environment-health-committee-workshop-report
#6
EDITORIAL
Erik Melén, Robert Barouki, Maeve Barry, H Marike Boezen, Barbara Hoffmann, Susanne Krauss-Etschmann, Gerard H Koppelman, Bertil Forsberg
No abstract text is available yet for this article.
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29604357/defining-innovation-in-neurosurgery-results-from-an-international-survey
#7
Mark M Zaki, David J Cote, Ivo S Muskens, Timothy R Smith, Marike L Broekman
BACKGROUND: Innovation is a part of the daily practice of neurosurgery. A clear definition of what constitutes innovation is currently lacking, however, and opinions vary from continent to continent, from hospital to hospital, and from surgeon to surgeon. METHODS: In this study, we distributed an online survey to neurosurgeons from multiple countries to investigate what neurosurgeons consider innovative, by gathering opinions on several hypothetical cases. The anonymous survey consisted of a total of 52 questions and took approximately 10 minutes to complete...
March 28, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29603032/association-of-reproductive-history-with-breast-tissue-characteristics-and-receptor-status-in-the-normal-breast
#8
Marike Gabrielson, Flaminia Chiesa, Catharina Behmer, Katarina Rönnow, Kamila Czene, Per Hall
INTRODUCTION: Reproductive history has been associated with breast cancer risk, but more knowledge of the underlying biological mechanisms is needed. Because of limited data on normal breast tissue from healthy women, we examined associations of reproductive history and established breast cancer risk factors with breast tissue composition and markers of hormone receptors and proliferation in a nested study within the Karolinska Mammography project for risk prediction for breast cancer (Karma)...
March 30, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29602855/how-will-south-africa-s-mandatory-salt-reduction-policy-affect-its-salt-iodisation-programme-a-cross-sectional-analysis-from-the-who-sage-wave-2-salt-tobacco-study
#9
Karen Charlton, Lisa Jayne Ware, Jeannine Baumgartner, Marike Cockeran, Aletta E Schutte, Nirmala Naidoo, Paul Kowal
OBJECTIVE: The WHO's global targets for non-communicable disease reduction recommend consumption of<5 g salt/day. In 2016, South Africa was the first country to legislate maximum salt levels in processed foods. South Africa's salt iodisation fortification programme has successfully addressed iodine deficiency but information is dated. Simultaneous monitoring of sodium reduction and iodine status is required to ensure compatibility of the two public health interventions. DESIGN/SETTING/PARTICIPANTS: A nested cohort design within WHO's 2015 Study on global AGEing and adult health (n=2887) including individuals from households across South Africa...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29579103/a-metagenomic-viral-discovery-approach-identifies-potential-zoonotic-and-novel-mammalian-viruses-in-neoromicia-bats-within-south-africa
#10
Marike Geldenhuys, Marinda Mortlock, Jacqueline Weyer, Oliver Bezuidt, Ernest C J Seamark, Teresa Kearney, Cheryl Gleasner, Tracy H Erkkila, Helen Cui, Wanda Markotter
Species within the Neoromicia bat genus are abundant and widely distributed in Africa. It is common for these insectivorous bats to roost in anthropogenic structures in urban regions. Additionally, Neoromicia capensis have previously been identified as potential hosts for Middle East respiratory syndrome (MERS)-related coronaviruses. This study aimed to ascertain the gastrointestinal virome of these bats, as viruses excreted in fecal material or which may be replicating in rectal or intestinal tissues have the greatest opportunities of coming into contact with other hosts...
2018: PloS One
https://www.readbyqxmd.com/read/29576763/corrigendum-genome-data-provides-high-support-for-generic-boundaries-in-burkholderia-sensu-lato
#11
Chrizelle W Beukes, Marike Palmer, Puseletso Manyaka, Wai Y Chan, Juanita R Avontuur, Elritha van Zyl, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, T B K Reddy, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Nikos Kyrpides, Tanja Woyke, Jochen Blom, William B Whitman, Stephanus N Venter, Emma T Steenkamp
[This corrects the article on p. 1154 in vol. 8, PMID: 28694797.].
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29570034/split-laminotomy-versus-conventional-laminotomy-postoperative-outcomes-in-pediatric-patients
#12
Elsa V Arocho-Quinones, Amie Kolimas, Peter S LaViolette, Bruce A Kaufman, Andrew B Foy, Marike Zwienenberg, Sean M Lew
OBJECTIVE Split laminotomy is a technique for accessing the spinal canal from the posterior midline that minimizes muscle dissection and bone removal. Benefits of this approach in minimizing postoperative pain and muscle atrophy in the adult population have been reported, but pediatric data are limited. Herein, the authors evaluate the benefits of the split laminotomy technique in pediatric patients. METHODS Data obtained in patients who underwent posterior spine surgery at Children's Hospital of Wisconsin for an intradural midline pathology between April 2008 and June 2015 were reviewed retrospectively...
March 23, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29556705/the-effectiveness-of-therapeutic-shoes-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#13
REVIEW
Marloes Tenten-Diepenmaat, Marike van der Leeden, Thea P M Vliet Vlieland, Leo D Roorda, Joost Dekker
The study summarizes the evidence on the effectiveness of therapeutic shoes on foot function, foot pain, physical functioning, health-related quality of life, adherence, adverse events and patient satisfaction in patients with rheumatoid arthritis (RA). Studies investigating the effect of (ready- or custom-made) therapeutic shoes were included. For between-group designs, studies comparing therapeutic shoes versus non-therapeutic shoes were included. A literature search was conducted in The Cochrane Central Registry for Controlled Trials (CENTRAL), PubMed, EMBASE and PEDro up to January 19, 2017...
March 20, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29547942/leveraging-lung-tissue-transcriptome-to-uncover-candidate-causal-genes-in-copd-genetic-associations
#14
Maxime Lamontagne, Jean-Christophe Bérubé, Ma'en Obeidat, Michael H Cho, Brian D Hobbs, Phuwanat Sakornsakolpat, Kim de Jong, H Marike Boezen, David Nickle, Ke Hao, Wim Timens, Maarten van den Berge, Philippe Joubert, Michel Laviolette, Don D Sin, Peter D Paré, Yohan Bossé
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current study aims at integrating genome-wide association studies (GWAS) and lung expression quantitative loci (eQTL) data to map COPD candidate causal genes and gain biological insights into the recently discovered COPD susceptibility loci. Two complementary genomic datasets on COPD were studied. First, the lung eQTL dataset which included whole-genome gene expression and genotyping data from 1,038 individuals. Second, the largest COPD GWAS to date from the International COPD Genetics Consortium (ICGC) with 13,710 cases and 38,062 controls...
March 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29536142/oversight-in-surgical-innovation-a-response-to-ethical-challenges
#15
REVIEW
Saksham Gupta, Ivo S Muskens, Luis Bradley Fandino, Alexander F C Hulsbergen, Marike L D Broekman
BACKGROUND: Surgical innovation has advanced outcomes in the field, but carries inherent risk for surgeons and patients alike. Oversight mechanisms exist to support surgeon-innovators through difficulties associated with the innovation process. METHODS: A literature review of ethical risks and oversight mechanisms was conducted. RESULTS: Oversight mechanisms range from the historical concept of surgical exceptionalism to departmental, hospital, and centralized committees...
March 13, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29531960/lower-leg-chronic-exertional-compartment-syndrome-in-patients-50-years-of-age-and-older
#16
Johan A de Bruijn, Aniek P M van Zantvoort, Michiel B Winkes, Marike van der Cruijsen-Raaijmakers, Adwin R Hoogeveen, Joep A W Teijink, Marc R M Scheltinga
Background: Lower leg chronic exertional compartment syndrome (CECS) is usually diagnosed in young and athletic individuals. The presence of CECS in older patients has received little attention in the literature, and patient characteristics are unknown. Purpose: To determine the prevalence of CECS in older patients (≥50 years) and to assess whether older patients with CECS differ clinically from younger patients with CECS. Study Design: Cohort study; Level of evidence, 3...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29526001/analysis-of-cell-shape-and-cell-migration-of-drosophila-macrophages-in-vivo
#17
Marike Rüder, Benedikt M Nagel, Sven Bogdan
The most abundant immune cells in Drosophila are macrophage-like plasmatocytes that fulfill central roles in morphogenesis, immune and tissue damage response. The various genetic tools available in Drosophila together with high-resolution and live-imaging microscopy techniques make Drosophila macrophages an excellent model system that combines many advantages of cultured cells with in vivo genetics. Here, we describe the isolation and staining of macrophages from larvae for ex vivo structured illumination microscopy (SIM), the preparation of white prepupae for in vivo 2D random cell migration analysis, and the preparation of pupae (18 h after puparium formation, APF) for in vivo 3D directed cell migration analysis upon wounding using spinning disk microscopy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29506594/blood-eosinophil-count-and-metabolic-cardiac-and-pulmonary-outcomes-a-mendelian-randomization-study
#18
Marzyeh Amini, Judith M Vonk, Ali Abbasi, Bram P Prins, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Gerard H Koppelman, Bruce H R Wolffenbuttel, H Marike Boezen, Harold Snieder, Daniel I Chasman, Behrooz Z Alizadeh
Blood eosinophil count is associated with a variety of common complex outcomes in epidemiological observation. The aim of this study was to explore the causal association between determined blood eosinophil count and 20 common complex outcomes (10 metabolic, 6 cardiac, and 4 pulmonary). Through Mendelian randomization, we investigated genetic evidence for the genetically determined eosinophil in association with each outcomes using individual-level LifeLines cohort data (n = 13,301), where a weighted eosinophil genetic risk score comprising five eosinophil associated variants was created...
March 6, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29501832/hyperpigmentation-and-higher-incidence-of-cutaneous-malignancies-in-moderate-high-pcb-and-dioxin-exposed-individuals
#19
Marike M Leijs, André Esser, Philipp M Amann, Thomas Schettgen, Monika Gube, Hans F Merk, Thomas Kraus, Jens M Baron
Polychlorinated biphenyls (PCB) are well known persistent and toxic environmental pollutants. Our aim was to identify effects of moderate-high exposure to dioxin-like (dl) and non-dioxin-like (ndl)-PCBs on the skin in order to provide more insight in the pathophysiological effects of these compounds. We performed a dermatological examination on 92 former workers from a transformer recycling company with known elevated serum PCB and/or dioxin (polychlorinated dibenzo-p-dioxin/polychlorinated dibenzo-p-furan (PCDD/F)) levels...
March 1, 2018: Environmental Research
https://www.readbyqxmd.com/read/29485394/mixta-gen-nov-a-new-genus-in-the-erwiniaceae
#20
Marike Palmer, Emma T Steenkamp, Martin P A Coetzee, Juanita R Avontuur, Wai-Yin Chan, Elritha van Zyl, Jochen Blom, Stephanus N Venter
The Erwiniaceae contain many species of agricultural and clinical importance. Although relationships among most of the genera in this family are relatively well resolved, the phylogenetic placement of several taxa remains ambiguous. In this study, we aimed to address these uncertainties by using a combination of phylogenetic and genomic approaches. Our multilocus sequence analysis and genome-based maximum-likelihood phylogenies revealed that the arsenate-reducing strain IMH and plant-associated strain ATCC 700886, both previously presumptively identified as members of Pantoea, represent novel species of Erwinia...
February 27, 2018: International Journal of Systematic and Evolutionary Microbiology
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