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https://www.readbyqxmd.com/read/29927677/8-f2-isoprostane-thioredoxin-and-thioredoxin-reductase-levels-in-children-with-obsessive-compulsive-disorder
#1
Ayhan Bilgiç, Rukiye Çolak Sivri, İbrahim Kılınç
PURPOSE: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD. MATERIALS AND METHODS: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale...
June 21, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29898190/obsessive-compulsive-symptoms-in-children-with-first-degree-relatives-diagnosed-with-obsessive-compulsive-disorder
#2
Priscila Chacon, Elisa Bernardes, Lívia Faggian, Marcelo Batistuzzo, Tais Moriyama, Eurípedes C Miguel, Guilherme V Polanczyk
OBJECTIVE: A first-degree relative affected by obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) in childhood is an important risk factor for developing the disorder in adulthood. The relationship between a family history of OCD and the presence of OCS and its correlates in childhood is not well established. METHODS: A total of 66 children whose parents or siblings have been diagnosed with OCD were assessed for the presence of OCS and clinical correlates...
June 11, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29795071/autism-spectrum-disorders-in-children-affected-by-duchenne-muscular-dystrophy
#3
Lucia Parisi, Teresa Di Filippo, Pasqualino Glorioso, Sabina La Grutta, Maria S Epifanio, Michele Roccella
BACKGROUND: Duchenne muscular dystrophy (DMD) is the most frequent and severe form of the dystrophinopathies. The literature shows that about 30-40% of DMD subjects have intellectual disability. In males with Duchenne muscular dystrophy, neuropsychiatric disorders have also been observed: attention deficit disorder and hyperactivity, autism spectrum disorders, and obsessive-compulsive disorder. Duchenne muscular dystrophy is not just a muscle disorder, but also a disease that affects the brain...
June 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29739129/evaluation-of-relationship-between-obsessive-compulsive-disorder-and-dissociative-experiences
#4
Mustafa Tatlı, Ozlem Cetinkaya, Fulya Maner
Objective: The aim of the study is to evaluate the relationship between obsessive-compulsive disorder (OCD) symptoms and dissociative experiences and the effect of childhood traumatic experiences on this relationship in OCD patients. Methods: Fifty consecutive OCD patients and 50 healthy controls are enrolled for this study. Sociodemographic and Clinical Data Form, Dissociative Experiences Scale (DES), Padua Inventory (PI) and Childhood Trauma Questionnaire (CTQ) are applied to participants...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29713171/does-higher-severity-really-correlate-with-a-worse-quality-of-life-in-obsessive-compulsive-disorder-a-meta-regression
#5
Andrea Pozza, Christine Lochner, Fabio Ferretti, Alessandro Cuomo, Anna Coluccia
Background: Obsessive-compulsive disorder (OCD) is one of the leading causes of disability and reduced quality of life (QOL), with impairment in a number of domains. However, there is a paucity of literature on the association between severity of OCD symptoms and QOL, and the data that do exist are inconsistent. In addition, the role of severity in QOL has not been summarized as yet from a cross-generational perspective (ie, across childhood/adolescence and adulthood). Through meta-regression techniques, the current study summarized evidence about the moderator role of severity of OCD symptoms on differences in global QOL between individuals with OCD and controls...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29702436/intra-individual-variability-across-cognitive-task-in-drug-na%C3%A3-ve-pediatric-patients-with-obsessive-compulsive-disorder
#6
Kosuke Okazaki, Kazuhiko Yamamuro, Junzo Iida, Toyosaku Ota, Yoko Nakanishi, Hiroki Matsuura, Mitsuhiro Uratani, Satomi Sawada, Takahiro Azechi, Naoko Kishimoto, Toshifumi Kishimoto
Attention deficit is commonly observed in several psychiatric conditions. In particular, patients with attention deficit hyperactivity disorder exhibit not only attention deficit, but also intra-individual variability in response times (IIV-RT) during the performance of cognitive tasks related to attention span and sustained attention. Although obsessive compulsive disorder (OCD) is commonly observed across childhood, little is known about abnormalities in IIV-RT during the auditory odd-ball task, and how these changes relate to event-related potentials (ERPs) components...
June 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29690990/-movement-disorders-in-children-and-adolescents
#7
Asli Sena Kücükyildiz, Nanette Mol Debes, Liselotte Skov
Tourette syndrome, obsessive-compulsive disorder, ticlike compulsions and motoric stereotypies are all movement disorders, which start in childhood and can be difficult to differentiate. In this article, we have outlined the most important focus points on how to differentiate the conditions in order to diagnose correctly and in order to refer to proper treatment.
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29689421/immune-system-and-obsessive-compulsive-disorder
#8
REVIEW
Donatella Marazziti, Federico Mucci, Leonardo F Fontenelle
BACKGROUND: Recently, much attention has been devoted to the possible alterations of the immune system in obsessive-compulsive disorder (OCD). Therefore, the aim of this paper was to review the current literature on the relationships between OCD and immune system. METHODS: A PubMed and Google Scholar search was performed with specific keywords. RESULTS: In the childhood, much emphasis has been given to the relationship between group A Streptococcus (GAS) infection and the development of a group of clinical syndromes characterized by neuropsychiatric symptoms known as "pediatric autoimmune neuropsychiatric disorders associated with streptococcus" (PANDAS)...
July 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29619935/tourette-syndrome-in-a-longitudinal-perspective-clinical-course-of-tics-and-comorbidities-coexisting-psychopathologies-phenotypes-and-predictors
#9
Camilla Groth
Tourette syndrome (TS) is a childhood onset neurodevelopmental disorder characterised by motor and vocal tics and frequent associated comorbidities. The developmental trajectory of tic shows tic-onset in the age of 4-6, peak in the age of 10-12 and decline during adolescence, although only few and small longitudinal studies form the basis of this evidence. Recent studies suggest that comorbid obsessive-compulsive disorder (OCD), attention deficit-hyperactivity disorder (ADHD) and coexisting psychopathologies tend to persist and become more dominant in adolescence...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29615141/children-s-naive-concepts-of-ocd-and-how-they-are-affected-by-biomedical-versus-cognitive-behavioural-psychoeducation
#10
B Butlin, C Wilson
BACKGROUND: How we conceptualize mental health conditions is important as it impacts on a wide range of mediators of treatment outcome. We do not know how children intuitively conceptualize obsessive-compulsive disorder (OCD), nor do we know the relative impact of biomedical or cognitive behavioural conceptual explanations, yet both are being widely used in psychoeducation for children with OCD. AIMS: This study identified children's naive concepts of OCD, and the comparative impact of biomedical versus cognitive behavioural psychoeducation on perceived prognosis...
April 4, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29610979/behavioral-modeling-for-mental-health-using-machine-learning-algorithms
#11
M Srividya, S Mohanavalli, N Bhalaji
Mental health is an indicator of emotional, psychological and social well-being of an individual. It determines how an individual thinks, feels and handle situations. Positive mental health helps one to work productively and realize their full potential. Mental health is important at every stage of life, from childhood and adolescence through adulthood. Many factors contribute to mental health problems which lead to mental illness like stress, social anxiety, depression, obsessive compulsive disorder, drug addiction, and personality disorders...
April 3, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29521470/behavioral-symptoms-and-psychiatric-disorders-in-child-and-adolescent-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-chemotherapy-only
#12
Wei Liu, Yin Ting Cheung, Tara M Brinkman, Pia Banerjee, Deokumar Srivastava, Vikki G Nolan, Hongmei Zhang, James G Gurney, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Prevalence of emotional, behavioral, and psychiatric outcomes in child and adolescent survivors of childhood acute lymphoblastic leukemia treated on a chemotherapy-only protocol were not well defined. METHODS: Self- and parent-reported emotional and behavioral symptoms were assessed for 161 survivors of childhood acute lymphoblastic leukemia (51.0% female; mean [SD] age 12.1[2.6] years; 7.5[1.6] years post-diagnosis). Age- and sex-adjusted scores were calculated for standardized measures and compared with 90th percentile of norms...
March 9, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29473029/fluoxetine-administration-in-juvenile-monkeys-implications-for-pharmacotherapy-in-children
#13
REVIEW
Mari S Golub, Casey E Hogrefe, Richard J Sherwood, Christoph W Turck
Fluoxetine therapy has been approved for children with major depressive disorder and obsessive compulsive disorder for over 14 years and has expanded to other childhood behavior disorders. As use increases, more detail on fluoxetine effects during juvenile brain development can help maintain safe and effective use of this therapy. Here, a narrative review is provided of previously published findings from a large nonhuman primate project. Fluoxetine was administered to juvenile male rhesus monkeys for an extended period (2 years) prior to puberty...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29338800/a-preliminary-investigation-of-pathways-to-inflated-responsibility-beliefs-in-children-with-obsessive-compulsive-disorder
#14
Lindsey M Collins, Meredith E Coles
BACKGROUND: Cognitive theorists posit that inflated responsibility beliefs contribute to the development of obsessive compulsive disorder (OCD). Salkovskis et al. (1999) proposed that experiencing heightened responsibility, overprotective parents and rigid rules, and thinking one influenced or caused a negative life event act as 'pathways' to the development of inflated responsibility beliefs, thereby increasing risk for OCD. Studies in adults with OCD and non-clinical adolescents support the link between these experiences and responsibility beliefs (Coles et al...
May 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29304426/relationship-between-childhood-trauma-and-suicide-probability-in-obsessive-compulsive-disorder
#15
Rukiye Ay, Lale Gonenir Erbay
The aim of this study is to assess the relationship between childhood trauma with the probability of suicide in obsessive compulsive disorders. Sixty-seven patients who were diagnosed with OCD were included in the study out of the patients who were admitted to Malatya Training and Research Hospital psychiatry outpatient clinic. The research data were collected using Yale Brawn Obsessive Compulsive Scale (YBOCS), Beck Depression (BDS) and Beck Anxiety Scales (BAS), Childhood Trauma Questionnaire-28 (CTQ-28), and Suicide Probability Scale (SPS)...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29282341/-tourette-syndrome-clinical-features-and-pathophysiology
#16
Yoshiko Nomura
Tourette syndrome (TS) is a neuropsychiatric disorder with the onset in childhood. TS is a form of tic disorders, and characterized by the motor and vocal tics, and comorbidities such as attention deficit hyperkinetic and obsessive compulsive disorders. These symptoms appear age dependently, showing a wax and wane course, and subside or abolish by the late teens. Pathophysiology of TS involves the dysfunction of both motor and non-motor basal ganglia-thalamo-cortical circuitries. The nigrostriatal dopamine (DA) system takes the exponential decrement at the striatum...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29233751/differential-binding-of-antibodies-in-pandas-patients-to-cholinergic-interneurons-in-the-striatum
#17
Luciana R Frick, Maximiliano Rapanelli, Kantiya Jindachomthong, Paul Grant, James F Leckman, Susan Swedo, Kyle Williams, Christopher Pittenger
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS, is a syndrome of acute childhood onset of obsessive-compulsive disorder and other neuropsychiatric symptoms in the aftermath of an infection with Group A beta-hemolytic Streptococcus (GABHS). Its pathophysiology remains unclear. PANDAS has been proposed to result from cross-reactivity of antibodies raised against GABHS with brain antigens, but the targets of these antibodies are unclear and may be heterogeneous. We developed an in vivo assay in mice to characterize the cellular targets of antibodies in serum from individuals with PANDAS...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29156296/associations-between-severity-of-anxiety-and-clinical-and-biological-features-of-major-affective-disorders
#18
Fernanda Liboni Cavicchioli, Michael Maes, Chutima Roomruangwong, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, George Anderson, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Patients with major affective disorders (MAFD) with comorbid anxiety show a greater functional impairment than those without anxiety. The aim of this study is to delineate the associations between severity of anxiety in MAFD, namely bipolar disorder (BD) and major depression (MDD), and MAFD characteristics and serum high-density lipoprotein (HDL)-cholesterol levels. Recruited were 82 participants with anxiety disoders and 83 without anxiety disoders, including 101 MAFD patients and 51 healthy controls. We used the Hamilton Anxiety Rating Scale (HAM-A) to measure severity of anxiety and made the diagnoses of posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) and phobias...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29119300/longitudinal-outcomes-of-children-with-pediatric-autoimmune-neuropsychiatric-disorder-associated-with-streptococcal-infections-pandas
#19
RANDOMIZED CONTROLLED TRIAL
Jill Leon, Rebecca Hommer, Paul Grant, Cristan Farmer, Precilla D'Souza, Riley Kessler, Kyle Williams, James F Leckman, Susan Swedo
Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin (IVIG) (N = 35). Fourteen of eighteen children randomized to placebo received open label IVIG 6 weeks after the blinded infusion, so follow-up results reported below largely reflect outcomes in a population of children who received at least one dose of IVIG...
May 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29102817/low-frequency-fluctuation-of-brain-spontaneous-activity-and-obsessive-compulsive-symptoms-in-a-large-school-age-sample
#20
Marcelo Q Hoexter, Claudinei E Biazoli, Pedro G Alvarenga, Marcelo C Batistuzzo, Giovanni A Salum, Ary Gadelha, Pedro M Pan, Mauricio Anés, Leticia Mancini-Martins, Luciana M Moura, Carles Soriano-Mas, Marco A G Del' Aquilla, Edson Amaro, Luis A Rohde, Andrea P Jackowski, Rodrigo A Bressan, Euripedes C Miguel, Maria C do Rosario, João R Sato
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'...
January 2018: Journal of Psychiatric Research
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