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https://www.readbyqxmd.com/read/29619935/tourette-syndrome-in-a-longitudinal-perspective-clinical-course-of-tics-and-comorbidities-coexisting-psychopathologies-phenotypes-and-predictors
#1
Camilla Groth
Tourette syndrome (TS) is a childhood onset neurodevelopmental disorder characterised by motor and vocal tics and frequent associated comorbidities. The developmental trajectory of tic shows tic-onset in the age of 4-6, peak in the age of 10-12 and decline during adolescence, although only few and small longitudinal studies form the basis of this evidence. Recent studies suggest that comorbid obsessive-compulsive disorder (OCD), attention deficit-hyperactivity disorder (ADHD) and coexisting psychopathologies tend to persist and become more dominant in adolescence...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29615141/children-s-naive-concepts-of-ocd-and-how-they-are-affected-by-biomedical-versus-cognitive-behavioural-psychoeducation
#2
B Butlin, C Wilson
BACKGROUND: How we conceptualize mental health conditions is important as it impacts on a wide range of mediators of treatment outcome. We do not know how children intuitively conceptualize obsessive-compulsive disorder (OCD), nor do we know the relative impact of biomedical or cognitive behavioural conceptual explanations, yet both are being widely used in psychoeducation for children with OCD. AIMS: This study identified children's naive concepts of OCD, and the comparative impact of biomedical versus cognitive behavioural psychoeducation on perceived prognosis...
April 4, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29610979/behavioral-modeling-for-mental-health-using-machine-learning-algorithms
#3
M Srividya, S Mohanavalli, N Bhalaji
Mental health is an indicator of emotional, psychological and social well-being of an individual. It determines how an individual thinks, feels and handle situations. Positive mental health helps one to work productively and realize their full potential. Mental health is important at every stage of life, from childhood and adolescence through adulthood. Many factors contribute to mental health problems which lead to mental illness like stress, social anxiety, depression, obsessive compulsive disorder, drug addiction, and personality disorders...
April 3, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29521470/behavioral-symptoms-and-psychiatric-disorders-in-child-and-adolescent-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia-treated-with-chemotherapy-only
#4
Wei Liu, Yin Ting Cheung, Tara M Brinkman, Pia Banerjee, Deokumar Srivastava, Vikki G Nolan, Hongmei Zhang, James G Gurney, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Prevalence of emotional, behavioral, and psychiatric outcomes in child and adolescent survivors of childhood acute lymphoblastic leukemia treated on a chemotherapy-only protocol were not well defined. METHODS: Self- and parent-reported emotional and behavioral symptoms were assessed for 161 survivors of childhood acute lymphoblastic leukemia (51.0% female; mean [SD] age 12.1[2.6] years; 7.5[1.6] years post-diagnosis). Age- and sex-adjusted scores were calculated for standardized measures and compared with 90th percentile of norms...
March 9, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29473029/fluoxetine-administration-in-juvenile-monkeys-implications-for-pharmacotherapy-in-children
#5
REVIEW
Mari S Golub, Casey E Hogrefe, Richard J Sherwood, Christoph W Turck
Fluoxetine therapy has been approved for children with major depressive disorder and obsessive compulsive disorder for over 14 years and has expanded to other childhood behavior disorders. As use increases, more detail on fluoxetine effects during juvenile brain development can help maintain safe and effective use of this therapy. Here, a narrative review is provided of previously published findings from a large nonhuman primate project. Fluoxetine was administered to juvenile male rhesus monkeys for an extended period (2 years) prior to puberty...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29338800/a-preliminary-investigation-of-pathways-to-inflated-responsibility-beliefs-in-children-with-obsessive-compulsive-disorder
#6
Lindsey M Collins, Meredith E Coles
BACKGROUND: Cognitive theorists posit that inflated responsibility beliefs contribute to the development of obsessive compulsive disorder (OCD). Salkovskis et al. (1999) proposed that experiencing heightened responsibility, overprotective parents and rigid rules, and thinking one influenced or caused a negative life event act as 'pathways' to the development of inflated responsibility beliefs, thereby increasing risk for OCD. Studies in adults with OCD and non-clinical adolescents support the link between these experiences and responsibility beliefs (Coles et al...
January 17, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29304426/relationship-between-childhood-trauma-and-suicide-probability-in-obsessive-compulsive-disorder
#7
Rukiye Ay, Lale Gonenir Erbay
The aim of this study is to assess the relationship between childhood trauma with the probability of suicide in obsessive compulsive disorders. Sixty-seven patients who were diagnosed with OCD were included in the study out of the patients who were admitted to Malatya Training and Research Hospital psychiatry outpatient clinic. The research data were collected using Yale Brawn Obsessive Compulsive Scale (YBOCS), Beck Depression (BDS) and Beck Anxiety Scales (BAS), Childhood Trauma Questionnaire-28 (CTQ-28), and Suicide Probability Scale (SPS)...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29282341/-tourette-syndrome-clinical-features-and-pathophysiology
#8
Yoshiko Nomura
Tourette syndrome (TS) is a neuropsychiatric disorder with the onset in childhood. TS is a form of tic disorders, and characterized by the motor and vocal tics, and comorbidities such as attention deficit hyperkinetic and obsessive compulsive disorders. These symptoms appear age dependently, showing a wax and wane course, and subside or abolish by the late teens. Pathophysiology of TS involves the dysfunction of both motor and non-motor basal ganglia-thalamo-cortical circuitries. The nigrostriatal dopamine (DA) system takes the exponential decrement at the striatum...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29233751/differential-binding-of-antibodies-in-pandas-patients-to-cholinergic-interneurons-in-the-striatum
#9
Luciana R Frick, Maximiliano Rapanelli, Kantiya Jindachomthong, Paul Grant, James F Leckman, Susan Swedo, Kyle Williams, Christopher Pittenger
Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus, or PANDAS, is a syndrome of acute childhood onset of obsessive-compulsive disorder and other neuropsychiatric symptoms in the aftermath of an infection with Group A beta-hemolytic Streptococcus (GABHS). Its pathophysiology remains unclear. PANDAS has been proposed to result from cross-reactivity of antibodies raised against GABHS with brain antigens, but the targets of these antibodies are unclear and may be heterogeneous. We developed an in vivo assay in mice to characterize the cellular targets of antibodies in serum from individuals with PANDAS...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29156296/associations-between-severity-of-anxiety-and-clinical-and-biological-features-of-major-affective-disorders
#10
Fernanda Liboni Cavicchioli, Michael Maes, Chutima Roomruangwong, Kamila Landucci Bonifacio, Decio Sabbatini Barbosa, George Anderson, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Patients with major affective disorders (MAFD) with comorbid anxiety show a greater functional impairment than those without anxiety. The aim of this study is to delineate the associations between severity of anxiety in MAFD, namely bipolar disorder (BD) and major depression (MDD), and MAFD characteristics and serum high-density lipoprotein (HDL)-cholesterol levels. Recruited were 82 participants with anxiety disoders and 83 without anxiety disoders, including 101 MAFD patients and 51 healthy controls. We used the Hamilton Anxiety Rating Scale (HAM-A) to measure severity of anxiety and made the diagnoses of posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) and phobias...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29119300/longitudinal-outcomes-of-children-with-pediatric-autoimmune-neuropsychiatric-disorder-associated-with-streptococcal-infections-pandas
#11
Jill Leon, Rebecca Hommer, Paul Grant, Cristan Farmer, Precilla D'Souza, Riley Kessler, Kyle Williams, James F Leckman, Susan Swedo
Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin (IVIG) (N = 35). Fourteen of eighteen children randomized to placebo received open label IVIG 6 weeks after the blinded infusion, so follow-up results reported below largely reflect outcomes in a population of children who received at least one dose of IVIG...
November 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29102817/low-frequency-fluctuation-of-brain-spontaneous-activity-and-obsessive-compulsive-symptoms-in-a-large-school-age-sample
#12
Marcelo Q Hoexter, Claudinei E Biazoli, Pedro G Alvarenga, Marcelo C Batistuzzo, Giovanni A Salum, Ary Gadelha, Pedro M Pan, Mauricio Anés, Leticia Mancini-Martins, Luciana M Moura, Carles Soriano-Mas, Marco A G Del' Aquilla, Edson Amaro, Luis A Rohde, Andrea P Jackowski, Rodrigo A Bressan, Euripedes C Miguel, Maria C do Rosario, João R Sato
BACKGROUND: The present study was designed to explore alterations in brain dynamics at rest that are associated with Obsessive Compulsive Symptoms (OCS) in childhood by measuring low frequency fluctuation of spontaneous brain activity in a large school community sample from a developing country. METHOD: Resting state functional magnetic resonance imaging data were collected in a sample of 655 children and adolescents (6-15 years old) from the brazilian 'High Risk Cohort Study for Psychiatric Disorders (HRC)'...
October 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29098466/prevalence-and-predictors-of-hair-pulling-disorder-and-excoriation-disorder-in-tourette-syndrome
#13
Erica Greenberg, Esther S Tung, Caitlin Gauvin, Lisa Osiecki, Kelly G Yang, Erin Curley, Angela Essa, Cornelia Illmann, Paul Sandor, Yves Dion, Gholson J Lyon, Robert A King, Sabrina Darrow, Matthew E Hirschtritt, Cathy L Budman, Marco Grados, David L Pauls, Nancy J Keuthen, Carol A Mathews, Jeremiah M Scharf
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study...
November 2, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29053637/progress-in-genetic-studies-of-tourette-s-syndrome
#14
REVIEW
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong
Tourette's Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time. In addition to frequent tics, people with TS are at risk for associated problems including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and problems with sleep. TS occurs in most populations and ethnic groups worldwide, and it is more common in males than in females...
October 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28992712/-biologic-aspects-of-adhd-and-conduct-disorders-in-childhood-and-adolescence-selected-preventive-aspects
#15
Ivo Paclt, Nikol Přibilová
Next to environmental factors and problems with interpersonal interaction in family represent developmental findings the basic of understanding these disorders (ADHD, conduct disorders, obsessive-compulsive disorders, tic disorders etc.). Knowledges of neurodevelopment disorders represent new possibilities of prevention and treatment.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28918645/increasing-availability-of-exposure-therapy-through-intensive-group-treatment-for-childhood-anxiety-and-ocd
#16
Stephen P H Whiteside, Julie E Dammann, Michael S Tiede, Bridget K Biggs, Andrea Hillson Jensen
Archival data were used to examine the feasibility of a 5-day, clinic-based, intensive exposure-based cognitive-behavioral group therapy for childhood anxiety disorders (CADs) and obsessive-compulsive disorder (OCD). Participants were 143 children (82 girls) aged 6 to 19 years ( M = 13.93 years, SD = 2.9 years) with CADs or OCD (or both) in 28 consecutive groups. Repeated-measures ANOVA in the subsample ( n = 57) with complete treatment data indicated positive change on all variables from pretreatment to posttreatment with few differences between CADs and OCD patients...
September 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28881220/executive-function-predicts-cognitive-behavioral-therapy-response-in-childhood-obsessive-compulsive-disorder
#17
Katja Anna Hybel, Erik Lykke Mortensen, Rikke Lambek, Davíð R M A Højgaard, Per Hove Thomsen
Cognitive-behavioral therapy (CBT) is considered first-line treatment for childhood obsessive-compulsive disorder (OCD). Despite CBT's efficacy, too many children and adolescents do not fully respond to treatment, making the identification of predictors of treatment response highly relevant. Executive functions (EF) have been suggested to constitute such predictors, but studies with pediatric samples are scarce. In the present study, we investigated latent level EF test performance and ratings of daily life EF behavior as predictors of CBT response in pediatric OCD...
August 26, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28843916/anxiety-disorders-and-childhood-maltreatment-as-predictors-of-outcome-in-bipolar-disorder
#18
Barbara Pavlova, Nader Perroud, Paolo Cordera, Rudolf Uher, Martin Alda, Alexandre Dayer, Jean-Michel Aubry
BACKGROUND: Comorbid anxiety disorders and childhood maltreatment have each been linked with unfavourable outcomes in people with bipolar disorder. Because childhood maltreatment is associated with anxiety disorders in this population, their respective predictive value remains to be determined. METHODS: In 174 adults with bipolar disorder, we assessed childhood maltreatment using the Childhood Trauma Questionnaire and lifetime anxiety disorders with the MINI International Neuropsychiatric Interview...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28810815/social-selection-in-cohort-studies-and-later-representation-of-childhood-psychiatric-diagnoses-the-danish-national-birth-cohort
#19
Kathrine Bang Madsen, Lena Hohwü, Jin Liang Zhu, Jørn Olsen, Carsten Obel
AIM: This study aimed to estimate the relative representation of childhood psychiatric diagnoses and use of psychotropic medication in the Danish National Birth Cohort (DNBC) compared to the general population. METHODS: The general population was identified as all childbirths in Denmark during 1998-2002 ( N=344,160). Linking the DNBC ( N=91,442) and the general population to the Danish national health registries, all children were followed until they received an ICD-10 psychiatric diagnosis, had a prescription of psychotropic medication or to the end of follow-up in 2013...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28755454/comorbid-anxiety-moderates-the-relationship-between-depression-history-and-prefrontal-eeg-asymmetry
#20
Robin Nusslock, Alexander J Shackman, Brenton W McMenamin, Lawrence L Greischar, Richard J Davidson, Maria Kovacs
The internalizing spectrum of psychiatric disorders-depression and anxiety-are common, highly comorbid, and challenging to treat. Individuals with childhood onset depression have a particularly poor prognosis. There is compelling evidence that individuals with depression display reduced resting-state EEG activity at sensors overlying the left prefrontal cortex, even during periods of remission, but it remains unknown whether this asymmetry is evident among individuals with a comorbid anxiety disorder. Here, we demonstrate that women with a history of childhood onset depression and no anxiety disorder (n = 37) show reduced left lateral frontal activity compared to psychiatrically healthy controls (n = 69)...
January 2018: Psychophysiology
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