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Biphosphonate

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https://www.readbyqxmd.com/read/29709532/-severe-hypercalcemia-of-unusual-cause-looking-for-the-culprit-case-report-and-review-of-the-literature
#1
M Jalbert, A Mignot, A-S Gauchez, A-C Dobrokhotov, J Fourcade
INTRODUCTION: Hypercalcemia is not a rare event and can lead to severe consequences. Its main etiologies are primary hyperparathyroidism and neoplasic conditions. The iatrogenic etiology by vitamin D intoxication is more rarely found. CASE PRESENTATION: A 76-year-old finish woman comes to the emergency room for chest pain. Her medical history is impossible to specify due to the language barrier and initial confusion. She has severe hypercalcaemia (4.14mmol/L), renal insufficiency, cardiac arrhythmia later complicated by an ischemic cardiac episode...
April 27, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29706889/variation-in-antiosteoporotic-drug-prescribing-and-spending-across-spain-a-population-based-ecological-cross-sectional-study
#2
Gabriel Sanfélix-Gimeno, Julián Librero-López, Gracia Modroño-Riaño, Salvador Peiró, Clara L Rodríguez-Bernal
Introduction: Evidence has shown that utilization of antiosteoporotic medications does not correspond with risk, and studies on other therapies have shown that adequacy of pharmaceutical prescribing might vary between regions. Nevertheless, very few studies have addressed the variability in osteoporotic drug consumption. We aimed to describe variations in pharmaceutical utilization and spending on osteoporotic drugs between Health Areas (HA) in Spain. Methods: Population-based cross-sectional ecological study of expenditure and utilization of the five therapeutic groups marketed for osteoporosis treatment in Spain in 2009...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29390509/skeletal-related-events-and-overall-survival-of-patients-with-bone-metastasis-from-nonsmall-cell-lung-cancer-a-retrospective-analysis
#3
Pengyu Kong, Jinglong Yan, Donghui Liu, Ye Ji, Yufu Wang, Jinpeng Zhuang, Jincai Wang, Xiaowei Hu, Xiaolong Yue
Because of improving treatments and survival, 40% to 58% of patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer from at least one skeletal-related event (SRE), affecting their quality of life, but the natural history of SRE is poorly understood. The study aimed to examine the factors involved in SRE-free survival (SRS) and overall survival (OS) of patients with NSCLC and bone metastases.This was a retrospective study of 211 patients with bone metastasis from NSCLC and treated at the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and January 2012...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28927342/biomimetic-functionalized-surfaces-and-the-induction-of-bone-formation
#4
Ugo Ripamonti
Tissue engineering still needs to assign the molecular basis of pattern formation, tissue induction, and morphogenesis: What next to morphogens and stem cells? Macroporous biomimetic matrices per se, without the addition of the soluble osteogenic molecular signals of the transforming growth factor-β (TGF-β) supergene family, remarkably initiate the induction of bone formation. Carving geometries within different calcium phosphate-based macroporous bioreactors we show that geometric cues imprinted within the macroporous spaces initiate the spontaneous induction of bone...
November 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28891484/variable-expressivity-and-response-to-bisphosphonate-therapy-in-a-family-with-osteoporosis-pseudoglioma-syndrome
#5
Karthik B Tallapaka, Prajnya Ranganath, Ashwin Dalal
BACKGROUND: Osteoporosis pseudoglioma syndrome (OPPGS) is a rare autosomal recessive genetic disorder characterised by congenital blindness and osteoporosis, caused by biallelic mutations in the LRP5 gene. CASE CHARACTERISTICS: A consanguineous family with four OPPGS-affected members with variable expressivity. OBSERVATION: A novel homozygous missense pathogenic variant (c.3709C>T) was identified in the LRP5 gene. Good response to biphosphonate therapy was observed in all affected members...
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28806246/response-assessment-of-223ra-treatment-should-a-fluorocholine-pet-ct-be-performed
#6
Ana María García Vicente, Ángel Soriano Castrejón, Ruth Alvarez Cabellos, Belén Sanchez Gil, Nicolás Mohedano Mohedano
We present 3 cases of patients with castration-resistant prostate cancer and bone metastases treated with Ra, belonging to our prospective and multicenter ChoPET-Rad study. All patients underwent clinical, hematological, and biochemical monitoring between each Ra administration. Initial and follow-up F-fluorocholine PET/CT and Tc-biphosphonate bone scintigraphy were performed previously and after the third Ra administration. Both techniques correctly established the response to treatment, in agreement to the biochemical response, although differences in the disease expression (concordant and discordant patterns) were found because of the different radiotracer biodistribution and molecular information derived from them...
October 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28762443/atypical-femoral-fractures-and-biphosphonates
#7
Ali Jawad
[No Abstract Available].
August 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28725947/clinical-heterogeneity-of-sapho-syndrome-challenging-diagnose-and-treatment
#8
REVIEW
Francesco Cianci, Angelo Zoli, Elisa Gremese, Gianfranco Ferraccioli
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease which is often misdiagnosed and under-recognized, because of its peculiar and heterogeneous clinical presentation. Its main features consist of cutaneous and osteoarticular manifestations, the latter affecting more often the anterior chest wall and having typical radiologic findings. There are no validated diagnostic criteria for SAPHO and no guidelines for treatment, due mainly to its rarity; as a consequence, therapy is empirical and aimed to control pain and modifying inflammatory process...
September 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28497661/medication-related-osteonecrosis-of-the-jaw-risk-factors-in-patients-under-biphosphonate-versus-patients-under-antiresorptive-antiangiogenic-drugs
#9
Giulia Ghidini, Maddalena Manfredi, Ilaria Giovannacci, Giovanni Mergoni, Amin Sarraj, Maura Mureddu, Giovanna Giunta, Mauro Bonanini, Marco Meleti, Paolo Vescovi
BACKGROUND: Biphosphonate-related osteonecrosis of the jaw (BRONJ) is a potential side effect associated with the administration of bisphosphonates; the aim of this work is to highlight the possible epidemiological differences between two groups of patients affected by medication related osteonecrosis of the jaw (MRONJ) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, Italy, between January 2004 and June 2016. METHODS: Medical charts of 303 patients (214 females and 89 males, mean age: 67 years old) treated at the Center of Oral Medicine, Pathology and Laser Surgery of the Academic Hospital at the University of Parma, between January 2004 and June 2016, were retrospectively analyzed...
August 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28299027/the-effect-of-locally-administered-pamidronate-on-autogenous-bone-graft-in-maxillofacial-reconstruction-a-randomized-clinical-trial
#10
M Bayat, A Garajei, E Afshari Pour, M Hasheminasab, Y Ghorbani, M H Kalantar Motamedi, N Bahrami
BACKGROUND: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and can be used to control the undesirable bone resorption. OBJECTIVE: To assess the effect of administration of biphosphonates on bone resorption. METHODS: 20 patients with bony defects who were candidates for free autogenous grafts were randomized into "pamidronate" and "control" groups...
2017: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/28030966/systemic-drugs-that-influence-titanium-implant-osseointegration
#11
REVIEW
Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian, Simion Bran
Titanium implants are widely used on an increasing number of patients in orthopedic and dental medicine. Despite the good survival rates of these implants, failures that lead to important socio-economic consequences still exist. Recently, research aimed at improving implant fixation, a process called osseointegration, has focused on a new, innovative field: systemic delivery of drugs. Following implant fixation, patients receive systemic drugs that could either impair or enhance osseointegration; these drugs include anabolic and anti-catabolic bone-acting agents in addition to new treatments...
February 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/27895021/in-vitro-and-in-vivo-activities-of-sulfur-containing-linear-bisphosphonates-against-apicomplexan-parasites
#12
Sergio H Szajnman, Tamila Galaka, Zhu-Hong Li, Catherine Li, Nathan M Howell, María N Chao, Boris Striepen, Vasant Muralidharan, Silvia N J Moreno, Juan B Rodriguez
We tested a series of sulfur-containing linear bisphosphonates against Toxoplasma gondii, the etiologic agent of toxoplasmosis. The most potent compound (compound 22; 1-[(n-decylsulfonyl)ethyl]-1,1-bisphosphonic acid) is a sulfone-containing compound, which had a 50% effective concentration (EC50) of 0.11 ± 0.02 μM against intracellular tachyzoites. The compound showed low toxicity when tested in tissue culture with a selectivity index of >2,000. Compound 22 also showed high activity in vivo in a toxoplasmosis mouse model...
February 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27640992/process-quality-indicators-for-chronic-kidney-disease-risk-management-a-systematic-literature-review
#13
REVIEW
Kirsten P J Smits, Grigory Sidorenkov, Henk J G Bilo, Margriet Bouma, Gerjan J Navis, Petra Denig
BACKGROUND AND OBJECTIVES: Quality indicators (QIs) can be used for measuring the quality of actions of healthcare providers. This systematic review gives an overview of such QIs measuring processes of care for chronic kidney disease (CKD), and identifies the QIs that have content, face, operational and/or predictive validity. METHODS: PubMed and Embase were searched using a strategy combining the terms "quality of care," "quality indicators" and "chronic kidney disease"...
October 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27299924/how-do-i-manage-a-patient-with-biphosphonate-related-osteonecrosis-of-the-jaw-bronj
#14
Ajit Auluck
No abstract text is available yet for this article.
May 2016: Journal—Canadian Dental Association, Journal de L'Association Dentaire Canadienne
https://www.readbyqxmd.com/read/27284762/case-report-of-early-aseptic-loosening-of-total-hip-arthroplasty-in-monostotic-paget-disease-a-diagnostic-challenge
#15
Diana Crego-Vita, Daniel Aedo-Martín, Coral Sánchez-Pérez
Paget's disease of bone is a localised chronic osteopathy which produces bone deformities, bone hypervascularity, structural weakness and altered joint biomechanics. Although radiological diagnosis of Paget's disease of bone is usually straightforward, monostotic cases may potentially raise specific problems which require invasive and expensive procedures such as bone biopsies. The pelvis and upper femur are frequently affected, resulting in disabling hip disease that may require total hip arthroplasty. We report a case of Paget disease of bone in an 84-year-old woman, which was initially identified as avascular necrosis of the hip, reason for which she underwent total hip arthroplasty...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27223431/zoledronic-acid-impairs-stromal-reactivity-by-inhibiting-m2-macrophages-polarization-and-prostate-cancer-associated-fibroblasts
#16
Giuseppina Comito, Coral Pons Segura, Maria Letizia Taddei, Michele Lanciotti, Sergio Serni, Andrea Morandi, Paola Chiarugi, Elisa Giannoni
Zoledronic acid (ZA) is a biphosphonate used for osteoporosis treatment and also proved to be effective to reduce the pain induced by bone metastases when used as adjuvant therapy in solid cancers. However, it has been recently proposed that ZA could have direct anti-tumour effects, although the molecular mechanism is unknown. We herein unravel a novel anti-tumour activity of ZA in prostate cancer (PCa), by targeting the pro-tumorigenic properties of both stromal and immune cells. Particularly, we demonstrate that ZA impairs PCa-induced M2-macrophages polarization, reducing their pro-invasive effect on tumour cells and their pro-angiogenic features...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27141048/osteoporotic-spinal-burst-fracture-in-a-young-adult-as-first-presentation-of-systemic-mastocytosis
#17
Christina Ble, Parmenion P Tsitsopoulos, Dimitrios M Anestis, Sofia Hadjileontiadou, Triantafyllia Koletsa, Maria Papaioannou, Christos Tsonidis
Osteoporotic vertebral fractures are uncommon in young adults and usually indicate an underlying disease. Systemic mastocytosis is a myeloproliferative neoplasm, which can be associated with osteoporosis. A previously healthy 30-year-old man presented with an L4 burst fracture after lifting a heavy object. He was operated with laminectomy and posterior lumbar instrumentation. During surgery, abnormally soft bone was noted. Postoperatively, osteoporosis was confirmed with measurement of bone mineral density...
May 2, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27117306/-male-osteoporosis
#18
REVIEW
P Farahmand, R Spiegel, J D Ringe
BACKGROUND: Osteoporosis in men is an important public health problem with more than 1 million cases in Germany. Although osteoporotic fractures have a much higher mortality in men than in women, male patients are still underdiagnosed and undertreated. OBJECTIVE: Epidemiology of male osteoporosis and current treatment situation, pathophysiological aspects at the hormonal level, risk factors, diagnostic work-up and therapeutic options. MATERIAL AND METHODS: Overview of data concerning male osteoporosis, recommendations for diagnostic work-up and presentation of the study situation on pharmaceutical therapies...
June 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/26908951/aortic-stenosis-and-transthyretin-cardiac-amyloidosis-the-chicken-or-the-egg
#19
Arnault Galat, Aziz Guellich, Diane Bodez, Michel Slama, Marina Dijos, David Messika Zeitoun, Olivier Milleron, David Attias, Jean-Luc Dubois-Randé, Dania Mohty, Etienne Audureau, Emmanuel Teiger, Jean Rosso, Jean-Luc Monin, Thibaud Damy
BACKGROUND: Aortic stenosis (AS) and transthyretin cardiac amyloidosis (TTR-CA) are both frequent in elderly. The combination of these two diseases has never been investigated. AIMS: To describe patients with concomitant AS and TTR-CA. METHODS: Six cardiologic French centres identified retrospectively cases of patients with severe or moderate AS associated with TTR-CA hospitalized during the last 6 years. RESULTS: Sixteen patients were included...
December 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26843726/osteonecrosis-of-the-jaw-after-bisphosphonates-treatment-in-patients-with-multiple-myeloma
#20
Svetlana Krstevska, Sonja Genadieva Stavric, Lidija Cevrevska, Borce Georgjievski, Oliver Karanfilski, Tatjana Sotirova, Trajan Balkanov
BACKGROUND: Bone lytic lesion in Multiple myeloma are the most commonly presented symptoms which require treatment with bisphosphonates (BPs). BPs are providing supportive care, reducing the rate of skeletal morbidity but evidently not abolishing it, the criteria for stopping their administration have to be different from those used for classic antineoplastic drugs, and they should not be stopped when metastatic bone disease is progressing. Osteonecrosis of the jaw (ONJ) has been associated recently with the use of BPs...
December 2015: Medical Archives
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