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https://www.readbyqxmd.com/read/29046049/treatment-of-diabetic-foot-ulcers-with-therapeutic-magnetic-resonance-tmr%C3%A2-improves-the-quality-of-granulation-tissue
#1
Letizia Ferroni, Chiara Gardin, Andrea De Pieri, Maria Sambataro, Elena Seganfreddo, Chiara Goretti, Elisabetta Iacopi, Barbara Zavan, Alberto Piaggesi
Diabetic foot ulcers (DFUs) often result in severely adverse outcomes, such as serious infections, hospitalization, and lower extremity amputations. In last few years, to improve the outcome of DFUs, clinicians and researchers put their attention on the application of low intensity pulsating electro-magnetic fields through Therapeutic Magnetic Resonance (TMR®). In our study, patients with DFUs have been divided into two groups: The Sham Group treated with non-functioning TMR® device, and the Active Group treated with a functioning device...
August 7, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045736/clinical-trial-parameters-that-influence-outcomes-in-lupus-trials-that-use-the-systemic-lupus-erythematosus-responder-index
#2
Kenneth C Kalunian, Murray B Urowitz, David Isenberg, Joan T Merrill, Michelle Petri, Richard A Furie, Mary-Ann Morgan-Cox, Rebecca Taha, Steven Watts, Maria Silk, Matthew D Linnik
Objective: The SLE Responder Index (SRI) is a composite endpoint used in SLE trials. This investigation examined the clinical trial elements that drive response measured by the SRI. Methods: Analyses are based on data from two phase 3 trials (n = 2262) that evaluated the impact of an anti-B-cell activating factor antibody on disease activity using SRI-5 as the primary endpoint (ClinicalTrials.gov NCT01196091 and NCT01205438). Results: The SRI-5 response rate at week 52 for all patients was 32...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045605/diagnostics-for-yaws-eradication-insights-from-direct-next-generation-sequencing-of-cutaneous-strains-of-treponema-pallidum
#3
Michael Marks, Maria Fookes, Josef Wagner, Robert Butcher, Rosanna Ghinai, Oliver Sokana, Yaw-Adu Sarkodie, Sheila A Lukehart, Anthony W Solomon, David C W Mabey, Nicholas Thomson
Background: Yaws-like chronic ulcers can be caused by Treponema pallidum subsp. pertenue, Haemophilus ducreyi, or other still-undefined bacteria. To permit accurate evaluation of yaws elimination efforts programmatic use of molecular diagnostics is required. The accuracy and sensitivity of current tools remains unclear because our understanding of T. pallidum diversity is limited by the low number of sequenced genomes. Methods: We tested samples from patients with suspected yaws collected in previous studies in the Solomon Islands and Ghana...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29045487/the-psychosocial-impact-of-leg-ulcers-in-patients-with-sickle-cell-disease-i-don-t-want-them-to-know-my-little-secret
#4
Nkeiruka I Umeh, Brittany Ajegba, Ashley J Buscetta, Khadijah E Abdallah, Caterina P Minniti, Vence L Bonham
BACKGROUND: Sickle cell disease (SCD) impacts millions of individuals worldwide and more than 100,000 people in the United States. Leg ulcers are the most common cutaneous manifestation of SCD. The health status of individuals living with chronic leg ulcers is not only influenced by clinical manifestations such as pain duration and intensity, but also by psychosocial factors. Garnering insights into the psychosocial impact can provide a more holistic view of their influence on quality of life...
2017: PloS One
https://www.readbyqxmd.com/read/29045216/evaluation-and-management-of-lower-extremity-ulcers
#5
Adam J Singer, Apostolos Tassiopoulos, Robert S Kirsner
New England Journal of Medicine, Volume 377, Issue 16, Page 1559-1567, October 2017.
October 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29044793/clustering-of-prevention-behaviours-in-patients-with-high-risk-primary-melanoma
#6
Adèle C Green, Maria Celia B Hughes, Lena A von Schuckmann, Kiarash Khosrotehrani, B Mark Smithers
OBJECTIVE: Because melanoma patients are at high risk of further disease, we aimed to study their melanoma prevention behaviours. METHODS: In a large cohort of patients newly diagnosed with high-risk melanoma in Queensland, Australia, we assessed clustering of preventive behaviours using latent class analysis. We assessed associated factors with prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) estimated by Poisson regression, and also if preventive behaviour was associated with better tumour prognosis at diagnosis...
October 16, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29044680/effects-of-three-blood-derived-products-on-equine-corneal-cells-an-in-vitro-study
#7
J O Rushton, E Kammergruber, A Tichy, M Egerbacher, B Nell, S Gabner
BACKGROUND: Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, based on its anti-collagenolytic properties and the presence of growth factors promoting corneal wound healing. However, although other blood derived products i.e. platelet rich plasma (PRP), plasma rich in growth factors (PRGF) have been widely used in equine orthopaedics and in human ophthalmology, no reports of the effects of these blood derived products exist in equine ophthalmology...
October 16, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29044604/epstein-barr-virus-positive-mucocutaneous-ulcer-in-a-background-of-crohn-s-disease-and-waldenstr%C3%A3-m-macroglobulinemia-a-case-report-highlighting-diagnostic-pitfalls
#8
Larissa Sena Teixeira Mendes, James McCaul, Andrew Wotherspoon, Ayoma D Attygalle
A specialist haematopathology opinion was sought on a left palatine tonsillar excision biopsy performed for suspected carcinoma. The patient, a 72-year old male, presented with oropharyngeal dysphagia in May 2015 and was diagnosed with hypertrophic, ulcerated lichen planus on an incision biopsy of a white patch on the posterior third of the tongue. Topical steroids were commenced with clinical improvement. This article is protected by copyright. All rights reserved.
October 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29043868/determinants-of-optimal-bowel-function-in-ileal-pouch-anal-anastomosis-physiological-differences-contributing-to-pouch-function
#9
Marie Louise Sunde, Petr Ricanek, Tom Øresland, Jørgen Jahnsen, Nazir Naimy, Arne Engebreth Færden
BACKGROUND: Variability in functional outcome after ileal-pouch anal anastomosis (IPAA) is to a large extent unexplained. The aim of this study was to perform multiple physiological and biochemical tests including an endoscopic examination with histology on IPAA patients with well and poorly functioning pouches to determine factors, or combinations thereof, contributing to functional outcome. METHODS: All patients with ulcerative colitis undergoing restorative proctocolectomy between 2000 and 2013 (N = 108) were interviewed using a pouch functioning score...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043859/gastrointestinal-bleeding-associated-with-chronic-excessive-use-overdosing-with-topical-ketoprofen-patch-in-elderly-patient
#10
Sakiko Hirose, Kana Matsuura, Hiroko Kato-Hayashi, Akio Suzuki, Koichi Ohata, Ryo Kobayashi, Takashi Ibuka, Hiroshi Araki, Masahito Shimizu, Yoshinori Itoh
PURPOSE: Topical ketoprofen patch has been developed to reduce the risk of systemic adverse effects such as gastrointestinal injury and renal toxicity. MATERIALS AND METHODS: We reported here a case of lower intestinal bleeding associated with chronic excessive use of topical ketoprofen patch in an elderly patient. RESULTS: A 74-year-old female visited to the outpatient clinic of the Gifu University Hospital and admitted thereafter. She had fecal occult blood and anemia...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29043290/checkpoint-inhibitor-induced-colitis-a-new-type-of-inflammatory-bowel-disease
#11
Madeline Bertha, Emanuelle Bellaguara, Timothy Kuzel, Stephen Hanauer
Checkpoint inhibitors are immune-stimulatory antibodies that have transformed the management and prognosis of individuals with metastatic melanoma and other cancers. Checkpoint inhibitor-induced colitis is an increasingly recognized immune-related adverse event that shares many of the same phenotypical, serological, and histological characteristics of both Crohn's disease and ulcerative colitis, suggesting that checkpoint inhibitor-induced colitis may represent a new inflammatory bowel disease phenotype. We report a 73-year-old man with metastatic melanoma who developed ipilimumab-induced colitis with subsequent transformation to Crohn?s colitis-like phenotype after the addition of pembrolizumab...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29043209/perianal-langerhans-cell-histiocytosis-a-rare-presentation-in-an-adult-male
#12
Asmaa Gaber Abdou, Doha MaherTaie
Langerhans cell histiocytosis (LCH) is a rare disease characterized by a proliferation of cells that show immunophenotypic and ultrastructural similarities with antigen-presenting Langerhans cells of mucosal sites and skin. LCH in adults is rare, and there are still many undiagnosed/misdiagnosed patients. We describe LCH involvement of the perianal region of a 33-year-old male with a previous history of diabetes insipidus. The differential diagnosis and all the reported cases of LCH of the perianal skin involvement since its description in 1984 till 2016 are discussed...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29043071/recent-advances-in-the-management-of-peptic-ulcer-bleeding
#13
REVIEW
Ian Beales
Acute upper gastrointestinal haemorrhage due to peptic ulcer bleeding remains an important cause of emergency presentation and hospital admission. Despite advances in many aspects of management, peptic ulcer bleeding is still associated with significant morbidity, mortality, and healthcare costs. Comprehensive international guidelines have been published, but advances as well as controversies continue to evolve. Important recent advances include the evidence supporting a more restrictive transfusion strategy aiming for a target haemoglobin of 70-90 g/l...
2017: F1000Research
https://www.readbyqxmd.com/read/29042978/antiplatelet-drug-ticagrelor-delays-gastric-ulcer-healing-in-rats
#14
Jing-Jing Li, Xin-Ying Wu, Jing-Lou Chen, Guan-Rong Chen, Jun Xu, Ye Gu, Hong-Ping Song
Adenosine diphosphate P2Y12 receptor antagonist clopidogrel is not sufficiently safe for the gastric mucosa in patients with high risk of peptic ulcer, since it may impair healing of gastric erosions. However, the safety of the novel P2Y12 receptor antagonist ticagrelor in the gastric mucosa has not been elucidated to date. The present study aimed to examine whether ticagrelor delays gastric ulcer healing and to elucidate the involved mechanisms. Gastric kissing ulcers were produced in rats by luminal application of acetic acid solution, and ticagrelor was administered at dose of 10 or 20 mg/kg/day orally for 7 days...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042857/clinical-implications-of-associations-between-headache-and-gastrointestinal-disorders-a-study-using-the-hallym-smart-clinical-data-warehouse
#15
Sang-Hwa Lee, Jae-June Lee, Youngsuk Kwon, Jong-Ho Kim, Jong-Hee Sohn
BACKGROUND: The brain and gastrointestinal (GI) tract are strongly connected via neural, endocrine, and immune pathways. Previous studies suggest that headaches, especially migraines, may be associated with various GI disorders. However, upper GI endoscopy in migraineurs has shown a low prevalence of abnormal findings. Also, the majority of studies have not demonstrated an association between Helicobacter pylori (HP) infection and migraine, although a pathogenic role for HP infection in migraines has been suggested...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29042744/palatal-perforation-a-rare-complication-of-postanesthetic-necrosis
#16
Vidisha Gargi, Ravi Prakash Sasankoti Mohan, Nagaraju Kamarthi, Swati Gupta
The everyday practice of dentistry relies heavily on achieving adequate local anesthesia. Even though the safety record of local anesthetic agents is high, complications do occur. Palate is a favorable site for soft-tissue lesions. Various factors such as direct effects of the drug, blanching of the tissues during injection, relatively poor blood supply, and reactivation of the latent forms of herpes can all promote to tissue ischemia and a lesion in the palate. Among various complications, anesthetic necrotic ulcer is a rare and uncommon condition occurring mostly in the hard palate possibly after a local anesthetic infiltration...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042743/necrotizing-ulcerative-gingivitis
#17
Rayhana Malek, Amina Gharibi, Nadia Khlil, Jamila Kissa
Necrotizing ulcerative gingivitis (NUG) is a typical form of periodontal diseases. It has an acute clinical presentation with the distinctive characteristics of rapid onset of interdental gingival necrosis, gingival pain, bleeding, and halitosis. Systemic symptoms such as lymphadenopathy and malaise could be also found. There are various predisposing factors such as stress, nutritional deficiencies, and immune system dysfunctions, especially, HIV infection that seems to play a major role in the pathogenesis of NUG...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042446/clinical-and-metabolic-consequences-of-l-serine-supplementation-in-hereditary-sensory-and-autonomic-neuropathy-type-1c
#18
Mari Auranen, Jussi Toppila, Saranya Suriyanarayanan, Museer A Lone, Anders Paetau, Henna Tyynismaa, Thorsten Hornemann, Emil Ylikallio
Hereditary sensory neuropathy type 1 (HSAN1) may be the first genetic neuropathy amenable to a specific mechanism-based treatment, as L-serine supplementation can be used to lower the neurotoxic levels of 1-deoxysphingolipids (1-deoxySL) that cause the neurodegeneration. The treatment is so far untested in HSAN1C caused by variants in the serine palmitoyl transferase subunit 2 (SPTLC2) gene. The aim of this study was to establish whether oral L-serine lowers 1-deoxySL in a patient with HSAN1C, to perform a dose escalation to find the minimal effective dose, and to assess the safety profile and global metabolic effects of the treatment...
October 17, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29042175/calcitriol-promotes-proangiogenic-molecules-in-keratinocytes-in-a-diabetic-foot-ulcer-model
#19
Valentin Trujillo, Paulina Marín-Luevano, Irma González-Curiel, Adrián Rodríguez-Carlos, Maira Ramírez-Reyes, Esther Layseca-Espinosa, José A Enciso-Moreno, Lorenza Díaz, Bruno Rivas-Santiago
Foot ulceration is one of the most common and complex sequelae of diabetes mellitus, generally posing a therapeutic challenge due to poor healing responses and high rates of complications, including peripheral vascular disease, ischemia and infections. Calcitriol, the most active vitamin D metabolite, induces antimicrobial peptides production in keratinocytes from diabetic foot ulcers (DFU); however, little is known about its effects on angiogenic factors in this pathology. Herein we aimed at studying whether calcitriol induces angiogenic molecules in keratinocytes under normoxic and hypoxic conditions, and if these molecules are able to improve cell migration in vitro...
October 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29041955/pluripotent-nontumorigenic-multilineage-differentiating-stress-enduring-cells-muse-cells-a-seven-year-retrospective
#20
REVIEW
Samantha C Fisch, María L Gimeno, Julia D Phan, Ariel A Simerman, Daniel A Dumesic, Marcelo J Perone, Gregorio D Chazenbalk
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers...
October 18, 2017: Stem Cell Research & Therapy
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