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https://www.readbyqxmd.com/read/28107565/idermatopath-a-novel-software-tool-for-mitosis-detection-in-h-e-stained-tissue-sections-of-malignant-melanoma
#1
C Andres, B Andres-Belloni, R Hein, T Biedermann, A Schäpe, N Brieu, R Schönmeyer, M Yigitsoy, J Ring, G Schmidt, N Harder
BACKGROUND: Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Beside well defined prognostic factors such as tumor thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single mitosis can be difficult on Hematoxylin&Eosin slides alone. Several studies showed a big inter- and intra-individual variability in detecting the MR in MM even by very experienced investigators, thus raising the question for a computer assisted method...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107397/efficacy-and-safety-of-everolimus-for-maintenance-immunosuppression-of-kidney-transplantation-a-meta-analysis-of-randomized-controlled-trials
#2
Jinyu Liu, Dong Liu, Juan Li, Lan Zhu, Chengliang Zhang, Kai Lei, Qiling Xu, Ruxu You
BACKGROUND: Conversion to everolimus is often used in kidney transplantation to overcome calcineurin inhibitor (CNI) nephrotoxicity but there is conflicting evidence for this approach. OBJECTIVES: To investigate the benefits and harm from randomized clinical trials (RCTs) involving the conversion from CNI to everolimus after kidney transplantation. METHODS: Databases were searched up to March 2016. Two reviewers independently assessed trials for eligibility and quality, and extracted data...
2017: PloS One
https://www.readbyqxmd.com/read/28106635/survey-results-from-canada-and-some-latin-america-countries-2016-national-pressure-ulcer-advisory-panel-changes-in-terminology-and-definitions
#3
Elizabeth A Ayello, Guadalupe Maria Lobo Cordero, R Gary Sibbald
OBJECTIVE: Since the National Pressure Ulcer Advisory Panel (NPUAP) held its consensus conference in April 2016, various wound care specialists and professional organizations have been disseminating their response to the revised pressure injury staging definitions. The purpose of this survey was to get an objective perspective of the new NPUAP terminology and staging definitions changes from wound care colleagues outside the United States. PARTICIPANTS: In an attempt to obtain the opinions of wound care specialists outside the United States, a convenience sample from some countries in Latin America was invited to complete a survey during the Mexican Association for Integral Care and Wound Healing conference...
February 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#4
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28105902/cost-effectiveness-of-using-adjunctive-porcine-small-intestine-submucosa-tri-layer-matrix-compared-with-standard-care-in-managing-diabetic-foot-ulcers-in-the-us
#5
J F Guest, D Weidlich, H Singh, J La Fontaine, A Garrett, C J Abularrage, C R Waycaster
OBJECTIVE: To estimate the cost-effectiveness of using tri-layer porcine small intestine submucosa (SIS; Oasis Ultra) as an adjunct to standard care compared with standard care alone in managing diabetic foot ulcers (DFUs) in the US, from the perspective of Medicare. METHOD: A Markov model was constructed to simulate the management of diabetic neuropathic lower extremity ulcers over a period of one year in the US. The model was used to estimate the cost-effectiveness of initially using adjunctive SIS compared with standard care alone to treat a DFU in the US at 2016 prices...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28105899/clinic-visit-frequency-in-wound-care-matters-data-from-the-us-wound-registry
#6
M J Carter, C E Fife
OBJECTIVE: A previous study suggested that the frequency with which patients visit wound care clinics influences the rate of chronic wound healing but high bias was present with regard to wound care centre selection. The objective of this retrospective cohort study was to confirm this finding by using a very large sample size of diabetic foot ulcers (DFUs) from the US Wound Registry. METHOD: Patients who visited the clinic more than once for a new DFU were eligible for study inclusion...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28105618/-efficacy-analysis-of-fecal-microbiota-transplantation-in-the-treatment-of-406-cases-with-gastrointestinal-disorders
#7
Ning Li, Hongliang Tian, Chunlian Ma, Chao Ding, Xiaolong Ge, Lili Gu, Xuelei Zhang, Bo Yang, Yue Hua, Yifan Zhu, Yan Zhou
OBJECTIVE: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for gastrointestinal disorders. METHODS: Retrospective analysis of the clinical data of 406 patients who underwent FMT from May 2014 to April 2016 in the Intestinal Microenvironment Treatment Centre of Nanjing General Hospital was performed, including patients with constipation(276 cases), recurrent Clostridium Difficile infection (RCDI, 61 cases), ulcerative colitis(44 cases), irritable bowel syndrome (15 cases) and Crohn's disease(10 cases)...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28105483/gastric-acid-secretion-and-gastrin-release-during-continuous-vagal-neuromonitoring-in-thyroid-surgery
#8
Liu Xiaoli, Che-Wei Wu, Hoon Yub Kim, Wen Tian, Feng-Yu Chiang, Renbin Liu, Angkoon Anuwong, Gregory W Randolph, Gianlorenzo Dionigi, Matteo Lavazza
PURPOSE: The vagus nerve (VN) has essential regulatory roles in the gastric acid secretion and gastrin release. Continuous intraoperative neuromonitoring (CIONM) via VN stimulation is a promising technique in thyroid surgery because it potentially avoids injury to the recurrent laryngeal nerve. However, no studies have investigated changes in gastric acid secretion and gastrin release during CIONM. METHOD: This prospective study of 58 thyroid surgery patients compared gastric acid and serum gastrin at five time points: (1) before skin incision, (2) after baseline calibration of CIONM probe, (3) +20 min from baseline, (4) before probe removal, and (5) after extubation...
January 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28104987/estimation-of-quality-of-life-in-cypriot-patients-with-inflammatory-bowel-disease
#9
Maria Tsoukka, Eleni Jelastopulu, Giagkos Lavranos, George Charalambous
AIM: To investigate the health-related quality of life (HRQoL) of patients suffering with idiopathic inflammatory bowel disease (IBD). METHODS: The Greek validated version of the Short Inflammatory Bowel Disease Questionnaire was used for evaluating the quality of life of IBD patients. The questionnaire was distributed to 100 consecutive patients suffering from IBD and presenting for a clinic appointment at the endoscopy unit of Larnaca General Hospital during the period from October to November 2012...
January 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28104899/amino-acid-based-material-for-the-complementary-therapy-of-decubitus-ulcers
#10
Frederico Nogueira, Isabel C Gouveia
Chronic wounds, pressure sores, lesions and infections of microbial origin in bedridden, paralyzed or malnutrition patients remain the object of study of many researchers. There are several intrinsic and extrinsic factors involved in the development of these disorders, which are related to the patient's immune system, making it unable to respond effectively to the treatment of the wound. These factors can be properly controlled, giving particular importance to the ethiology and stage of the wound, as well as the time periods corresponding to the replacement of the dressings...
January 20, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28104580/leveraging-electronic-health-care-record-information-to-measure-pressure-ulcer-risk-in-veterans-with-spinal-cord-injury-a-longitudinal-study-protocol
#11
Stephen L Luther, Susan S Thomason, Sunil Sabharwal, Dezon K Finch, James McCart, Peter Toyinbo, Lina Bouayad, Michael E Matheny, Glenn T Gobbel, Gail Powell-Cope
BACKGROUND: Pressure ulcers (PrUs) are a frequent, serious, and costly complication for veterans with spinal cord injury (SCI). The health care team should periodically identify PrU risk, although there is no tool in the literature that has been found to be reliable, valid, and sensitive enough to assess risk in this vulnerable population. OBJECTIVE: The immediate goal is to develop a risk assessment model that validly estimates the probability of developing a PrU...
January 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28104503/invasive-candida-krusei-infection-and-candida-vasculitis-of-a-leg-ulcer-in-an-immunocompetent-patient-a-case-report
#12
Jud Philipp, Valentin Thomas, Regauer Sigrid, Gary Thomas, Hackl Gerald, Rief Peter, Brodmann Marianne, Hafner Franz
A 71year old female Caucasian farmer without any known immunosuppression presented with a painful ulcer of her right lower leg after a trauma caused by a wood billet. There was no response to empirical antibacterial treatment. An ulcer biopsy showed an invasive Candida infection of the soft tissue and leucocytoclastic vasculitis. Voriconazole treatment was followed by wound healing. Invasive Candida infection and localized Candida vasculitis represent a rare cause of persisting leg ulcers. The similar clinical picture of chronic venous leg ulcers might blur the true cause and refractory cases should therefore promptly be processed by histopathological diagnostics...
January 16, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28104319/the-mexican-consensus-on-probiotics-in-gastroenterology
#13
M A Valdovinos, E Montijo, A T Abreu, S Heller, A González-Garay, D Bacarreza, M Bielsa-Fernández, M C Bojórquez-Ramos, F Bosques-Padilla, A I Burguete-García, R Carmona-Sánchez, A Consuelo-Sánchez, E Coss-Adame, J A Chávez-Barrera, M de Ariño, J Flores-Calderón, O Gómez-Escudero, M S González-Huezo, M E Icaza-Chávez, A Larrosa-Haro, M Morales-Arámbula, C Murata, J A Ramírez-Mayans, J M Remes-Troche, T Rizo-Robles, M Peláez-Luna, E M Toro-Monjaraz, A Torre, M E Urquidi-Rivera, R Vázquez, J K Yamamoto-Furusho, F Guarner
INTRODUCTION: Probiotics are frequently prescribed in clinical practice. Their efficacy in treating gastrointestinal disorders is supported by a significant number of clinical trials. However, the correct prescription of these agents is hampered due to a lack of knowledge of the scientific evidence and to the different presentations and microbial compositions of the probiotics that are currently available. AIM: To provide the clinician with a consensus review of probiotics and recommendations for their use in gastroenterology...
January 16, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28104283/-led-lights-in-dermatology
#14
C Noé, M Pelletier-Aouizerate, H Cartier
The use in dermatology of light-emitting diodes (LEDs) continues to be surrounded by controversy. This is due mainly to poor knowledge of the physicochemical phases of a wide range of devices that are difficult to compare to one another, and also to divergences between irrefutable published evidence either at the level of in vitro studies or at the cellular level, and discordant clinical results in a variety of different indications: rejuvenation, acne, wound healing, leg ulcers, and cutaneous inflammatory or autoimmune processes...
January 16, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28104214/wound-blush-obtainment-is-the-most%C3%A2-important-angiographic-endpoint-for%C3%A2-wound-healing
#15
Makoto Utsunomiya, Mitsuyoshi Takahara, Osamu Iida, Yasutaka Yamauchi, Daizo Kawasaki, Yoshiaki Yokoi, Yoshimistu Soga, Norihiko Ohura, Masato Nakamura
OBJECTIVES: This study aimed to assess the optimal angiographic endpoint of endovascular therapy (EVT) for wound healing. BACKGROUND: Several reports have demonstrated acceptable patency and limb salvage rates following infrapopliteal interventions for the treatment of critical limb ischemia (CLI). However, the optimal angiographic endpoint of EVT remains unclear. METHODS: We conducted a subanalysis of the prospective multicenter OLIVE (Endovascular Treatment for Infrainguinal Vessels in Patients with Critical Limb Ischemia) registry investigation assessing patients who received infrainguinal EVT for CLI...
January 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28104141/tacrolimus-associated-diffuse-gastrointestinal-ulcerations-and-pathergy-a-case-report
#16
D Pan, O Shaye, J A Kobashigawa
Tacrolimus is a common immunosuppressive modality with a range of therapeutic applications, including for rheumatologic disease, nephrotic syndrome, and inflammatory bowel disease. The medication also plays an integral role in organ transplantation. However, tacrolimus has a significant side effect profile, which commonly includes nephrotoxicity, neurotoxicity, infection risk, and anemia. We describe an unusual case of tacrolimus toxicity in a cardiac transplant patient, manifesting as diffuse gastrointestinal ulcerations and pathergy...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28104092/the-use-of-indomethacin-in-the-prevention-of-postoperative-radioulnar-synostosis-after-distal-biceps-repair
#17
Callista L Costopoulos, Joseph A Abboud, Matthew L Ramsey, Charles L Getz, Daniel S Sholder, John P Taras, Daniel Huttman, Mark D Lazarus
BACKGROUND: This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. We hypothesized that indomethacin use postoperatively would decrease the occurrence of symptomatic synostosis. METHODS: A single-center retrospective record review identified 124 patients undergoing distal biceps repair between 2011 and 2014. Patients were analyzed for administration of indomethacin, contraindications to administration, age, time to surgery, fixation method, medical comorbidities, and development of symptomatic synostosis...
February 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28103938/the-gastro-protective-effects-of-cibotium-barometz-hair-on-ethanol-induced-gastric-ulcer-in-sprague-dawley-rats
#18
Nahla Saeed Al-Wajeeh, Maryam Hajerezaie, Suzita Mohd Noor, Mohammed Farouq Halabi, Nawal Al-Henhena, Ainnul Hamidah Syahadah Azizan, Sareh Kamran, Pouya Hassandarvish, Abdrabuh N Shwter, Hamed Karimian, Hapipah Mohd Ali, Mahmood Ameen Abdulla
BACKGROUND: Cibotium barometz is a medical herb used traditionally in the Malaysian peninsula for several ailments, including gastric ulcer. The aim of this study was assessment the anti-ulcer effects of C. barometz hair on ethanol-induced stomach hemorrhagic abrasions in animals. Seven groups of Sprague Dawley (SD) rats were administered 10% Tween 20 in the normal control and ulcer control groups, and omeprazole 20 mg/kg and 62.5, 125, 250, and 500 mg/kg of C. barometz hair extract in the experimental groups...
January 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28103857/ameliorative-potential-of-alstonia-scholaris-linn-r-br-against-chronic-constriction-injury-induced-neuropathic-pain-in-rats
#19
Hasandeep Singh, Rohit Arora, Saroj Arora, Balbir Singh
BACKGROUND: Alstonia scholaris commonly known as 'Saptaparni' is an Indian traditional medicinal plant used in Ayurveda. It is commonly used to treat various disorders like asthma, bronchitis, diarrhea, dysentery and malaria. In folklore medicine the milky juice of the plant is applied on wounds and ulcers to treat pain, ear ache and also in rheumatic pains. AIM: The present study was designed to investigate the potential of A. scholaris R. Br. in chronic constriction injury of sciatic nerve (CCI) induced neuropathic pain in rats...
January 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28103856/relationship-between-the-presence-of-baccalaureate-educated-rns-and-quality-of-care-a-cross-sectional-study-in-dutch-long-term-care-facilities
#20
Ramona Backhaus, Erik van Rossum, Hilde Verbeek, Ruud J G Halfens, Frans E S Tan, Elizabeth Capezuti, Jan P H Hamers
BACKGROUND: Recent evidence suggests that an increase in baccalaureate-educated registered nurses (BRNs) leads to better quality of care in hospitals. For geriatric long-term care facilities such as nursing homes, this relationship is less clear. Most studies assessing the relationship between nurse staffing and quality of care in long-term care facilities are US-based, and only a few have focused on the unique contribution of registered nurses. In this study, we focus on BRNs, as they are expected to serve as role models and change agents, while little is known about their unique contribution to quality of care in long-term care facilities...
January 19, 2017: BMC Health Services Research
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