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alpha-linolenic acid

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https://www.readbyqxmd.com/read/29331744/urinary-metabolomics-study-the-mechanism-of-taohong-siwu-decoction-intervention-in-acute-blood-stasis-model-rats-based-on-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#1
Xiaosong Zhang, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang, Yanming Wei
Taohong Siwu Decoction (TSD) is a classic prescription in traditional Chinese medicine and is widely used to promote blood circulation to remove blood stasis. However, the effect mechanisms are not yet well understood. Here, a urinary metabolomic approach based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC/Q-TOF-MS) was conducted to explore the changes in the endogenous metabolites and to assess the integral efficacy of TSD on acute blood stasis model rats. Then, parameters for hemorheology and coagulation functions were detected...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29304057/long-chain-omega-3-polyunsaturated-fatty-acid-dietary-intake-is-positively-associated-with-bone-mineral-density-in-normal-and-osteopenic-spanish-women
#2
Jesus Lavado-García, Raul Roncero-Martin, Jose M Moran, Maria Pedrera-Canal, Ignacio Aliaga, Olga Leal-Hernandez, Sergio Rico-Martin, Maria L Canal-Macias
The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA)...
2018: PloS One
https://www.readbyqxmd.com/read/29298969/-dietetary-recommendation-for-non-alcoholic-fatty-liver-disease
#3
REVIEW
Anna Jeznach-Steinhagen, Joanna Ostrowska, Aneta Czerwonogrodzka-Senczyna, Iwona Boniecka, Wioletta Gronostajska
Non-alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the developed world. Nowadays, in the adult population of Europe it is estimated at 14% to 21%. Its most important risk factors are obesity and metabolic syndrome. Introducing lifestyle changes such as: dietary intervention and increased physical activity are the first-line treatment and are intended to support not only NAFLD but also associated diseases such as obesity, insulin resistance, diabetes and dyslipidemia...
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29288354/functional-characterization-and-substrate-specificity-analysis-of-%C3%AE-6-desaturase-from-marine-microalga-isochrysis-sp
#4
S Thiyagarajan, M Arumugam, N Senthil, S Vellaikumar, S Kathiresan
OBJECTIVES: To express a Δ6-desaturase gene and produce gamma-linolenic acid (GLA) and stearidonic acid (SDA) in prokaryotic expression system (Escherichia coli), and analyze its substrate specificity in the omega-3 fatty acid biosynthetic pathway. RESULTS: Full-length ORF (1448 bp) of Δ6Des-Iso was isolated from Isochrysis sp. and characterized using multiple sequence alignment, phylogenetic analysis, transmembrane domain, and protein tertiary structure. Δ6Des-Iso is a front-end desaturase consisting of three conserved histidine domains and a cytochrome b5 domain...
December 29, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29286866/omega-3-fatty-acid-deficiency-impairs-frontostriatal-recruitment-following-repeated-amphetamine-treatment-in-rats-a-7-tesla-in-vivo-phmri-study
#5
Robert K McNamara, Jennifer D Schurdak, Ruth H Asch, Diana M Lindquist
Although attention deficit hyperactivity disorder is associated with deficits in docosahexaenoic acid (DHA), an omega-3 fatty acid implicated in dopamine and glutamate synaptic plasticity, its role in neuroplastic brain changes that occur following repeated amphetamine (AMPH) treatment are not known. This study used pharmacological magnetic resonance imaging to investigate the impact of repeated AMPH exposure and alterations in brain DHA levels on AMPH-induced brain activation patterns. Male rats were fed a diet with no n-3 fatty acids (Deficient, DEF, n = 20), a diet fortified with preformed DHA (fish oil, FO, n = 20), or a control diet fortified with alpha-linolenic acid (n = 20) from P21 to P90...
December 29, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29275214/de-novo-transcriptome-assembly-and-comparative-analysis-between-male-and-benzyladenine-induced-female-inflorescence-buds-of-plukenetia-volubilis
#6
Qiantang Fu, Longjian Niu, Mao-Sheng Chen, Yan-Bin Tao, Xiulan Wang, Huiying He, Bang-Zhen Pan, Zeng-Fu Xu
Plukenetia volubilis is a promising oilseed crop due to its seeds being rich in unsaturated fatty acids, especially alpha-linolenic acid. P. volubilis is monoecious, with separate male and female flowers on the same inflorescence. We previously reported that male flowers were converted to female flowers by exogenous cytokinin (6-benzyladenine, 6-BA) treatment in P. volubilis. To identify candidate genes associated with floral sex differentiation of P. volubilis, we performed de novo transcriptome assembly and comparative analysis on control male inflorescence buds (MIB) and female inflorescence buds (FIB) induced by 6-BA using Illumina sequencing technology...
December 9, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29249532/omega-3-pufa-modulate-lipogenesis-er-stress-and-mitochondrial-dysfunction-markers-in-nash-proteomic-and-lipidomic-insight
#7
Lívia Samara Dos Reis Rodrigues Okada, Claudia P Oliveira, José Tadeu Stefano, Monize Aydar Nogueira, Ismael Dale Cotrim Guerreiro da Silva, Fernanda Bertucce Cordeiro, Venâncio Avancini Ferreira Alves, Raquel Susana Torrinhas, Flair José Carrilho, Puneet Puri, Dan L Waitzberg
BACKGROUND & AIMS: Currently there is no FDA-approved therapy for nonalcoholic steatohepatitis (NASH). Increased n-6/n-3 polyunsaturated fatty acids (PUFA) ratio can induce endoplasmic reticulum (ER) stress and mitochondrial dysfunction that characterize NASH. Our recent study with n-3 PUFA showed improvement in individual histologic parameters like steatosis, ballooning and lobular inflammation. We hypothesized that n-3 PUFA therapy mediated improvement in histologic parameters is modulated by lipidomic and proteomic changes...
September 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29246284/consumption-of-alpha-linolenic-acid-enriched-diacylglycerol-induces-increase-in-dietary-fat-oxidation-compared-with-alpha-linolenic-acid-enriched-triacylglycerol-a-randomized-double-blind-trial
#8
Yasutoshi Ando, Shinichiro Saito, Hirona Miura, Noriko Osaki, Yoshihisa Katsuragi
Fat metabolism is an important consideration in obesity. Alpha-linolenic acid-enriched diacylglycerol (ALA-DAG), which mainly occurs as ALA esterifies to 1,3-diacyl-sn-glycerol (1,3-DAG), has beneficial effects on fat metabolism and body weight compared with triacylglycerol (TAG). Moreover, compared with ALA-TAG, ALA-DAG enhances β-oxidation activity in the small intestine and liver in rodents. We hypothesized that ALA-DAG consumption may increase dietary fat oxidation compared with ALA-TAG in humans. To examine this hypothesis, we conducted a randomized double-blind cross-over trial in 17 normal and moderately obese men and women (BMI: 25...
December 2017: Nutrition Research
https://www.readbyqxmd.com/read/29234072/biochemical-and-transcriptomic-analyses-of-drought-stress-responses-of-ly1306-tobacco-strain
#9
Huijuan Yang, Li Zhao, Shimin Zhao, Jing Wang, Hongzhi Shi
This study aimed to investigate drought resistance of the LY1306 tobacco strain. Seedlings of tobacco strains LY1306, ZhongYan 100 (ZY100) and Hong Hua Da Jin Yuan (HHDJY) were treated with polyethylene glycol (PEG)-6000 to induce osmotic stress. As validation, water-deficit-induced drought treatments, including mild drought (MD; watering 1.5 L/week) and severe drought (SD, without watering) were carried out. Changes in cell morphology, leaf water potential, antioxidant enzyme activity, as well as contents of malondialdehyde (MDA) and proline were determined for each treatment...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232610/electrospun-polydimethylsiloxane-polyacrylonitrile-titanium-dioxide-nanofibers-as-a-new-coating-for-determination-of-alpha-linolenic-acid-in-milk-by-direct-immersion-solid-phase-nanoextraction
#10
Sahar Sadeghi, Afsaneh Mollahosseini
In this study, polydimethylsiloxane/polyacrylonitrile/titanium dioxide (PDMS/PAN/TiO2) nanofibers were synthesized via electrospinning method to extract and quantify alpha-linolenic acid (ALA, C18:3), as a model analyte, in milk by direct immersion-solid phase nanoextraction (DI-SPNE) with gas chromatography-flame ionization detector (GC-FID). The affecting factors on the electrospinning process such as, PDMS concentration, amount of TiO2 nanoparticles (NPs), voltage, and electrospinning distance were optimized using Taguchi's orthogonal design...
December 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29217628/conversion-efficiency-of-alpha-linolenic-acid-to-omega-3-highly-unsaturated-fatty-acids-in-aerial-insectivore-chicks
#11
Cornelia W Twining, Peter Lawrence, David W Winkler, Alexander S Flecker, J Thomas Brenna
Food availability and quality are both critical for growing young animals. In nature, swallows (Tachycineta bicolor) and other aerial insectivores feed on both aquatic insects, which are rich in omega-3 highly unsaturated fatty acids (HUFA) and terrestrial insects, which contain considerably lower amounts of omega-3 HUFA. Carnivorous mammals and fishes must obtain omega-3 HUFA from diet, as they have lost the capacity to convert the precursor omega-3 ALA into omega-3 HUFA. Thus, the relative value of aquatic versus terrestrial insects depends not only on the fatty acid composition of the prey, but also upon the capacity of consumers to convert ALA into omega-3 HUFA...
December 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29150481/identification-of-pleiotropic-cancer-susceptibility-variants-from-genome-wide-association-studies-reveals-functional-characteristics
#12
Yi-Hsuan Wu, Rebecca E Graff, Michael N Passarelli, Joshua D Hoffman, Elad Ziv, Thomas J Hoffmann, John S Witte
BACKGROUND: There exists compelling evidence that some genetic variants are associated with the risk of multiple cancer sites (i.e., pleiotropy). However, the biological mechanisms through which the pleiotropic variants operate are unclear. METHODS: We obtained all cancer risk associations from the National Human Genome Research Institute-European Bioinformatics Institute GWAS Catalog, and correlated cancer risk variants were clustered into groups. Pleiotropic variant groups and genes were functionally annotated...
November 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29146138/development-of-kidney-transplant-fibrosis-is-inversely-associated-with-plasma-marine-fatty-acid-level
#13
Ivar A Eide, Christina Dörje, My Svensson, Trond Jenssen, Clara Hammarstrøm, Helge Scott, Kristian S Bjerve, Jeppe H Christensen, Erik B Schmidt, Anders Hartmann, Anders Åsberg, Anna V Reisæter, Finn P Reinholt
OBJECTIVE(S): We assessed associations between plasma levels of polyunsaturated fatty acids (PUFAs) and degree of inflammation and interstitial fibrosis in transplanted kidneys. DESIGN: The design of the study was single center cohort study. SUBJECTS: A study population of 156 patients who received a kidney transplant at Oslo University Hospital during 2010. MAIN OUTCOME MEASURE: Kidney transplant biopsies were obtained at 2 months and 1 year after transplantation...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29137111/effect-of-omega-3-fatty-acid-supplementation-on-plasma-fibroblast-growth-factor-23-levels-in-post-myocardial-infarction-patients-with-chronic-kidney-disease-the-alpha-omega-trial
#14
Martin H de Borst, Leandro C Baia, Ellen K Hoogeveen, Erik J Giltay, Gerjan Navis, Stephan J L Bakker, Johanna M Geleijnse, Daan Kromhout, Sabita S Soedamah-Muthu
Fibroblast growth factor 23 (FGF23) is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3) fatty acid consumption has been inversely associated with FGF23 levels and with cardiovascular risk. We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and plant-derived alpha-linolenic acid (ALA) on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. In the randomized double-blind Alpha Omega Trial, 4837 patients with a history of myocardial infarction aged 60-80 years (81% men) were randomized to one of four trial margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 41 months...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29101172/flaxseed-its-bioactive-components-and-their-cardiovascular-benefits
#15
Mihir Parikh, Thomas Netticadan, Grant N Pierce
Cardiovascular disease remains the leading cause of mortality and morbidity world-wide. The inclusion of functional foods and natural health products in the diet are gaining increasing recognition as integral components of lifestyle changes in the fight against cardiovascular disease. Several preclinical and clinical studies have shown the beneficial cardiovascular effects of dietary supplementation with flaxseed. The cardiovascular effects of dietary flaxseed have included an anti-hypertensive action, anti-atherogenic effects, a lowering of cholesterol, an anti-inflammatory action and an inhibition of arrhythmias...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29092397/alpha-linolenic-acid-from-perilla-frutescens-var-japonica-oil-protects-a%C3%AE-induced-cognitive-impairment-through-regulation-of-app-processing-and-a%C3%AE-degradation
#16
Ah Young Lee, Myoung Hee Lee, Sanghyun Lee, Eun Ju Cho
Alzheimer's disease (AD) is characterized by progressive cognitive and memory impairment. The major pathological hallmark of AD is the accumulation of amyloid beta (Aβ), which is produced from the amyloid precursor protein (APP) through cleavage of β- and γ-secretase. Recently, dietary plant oil containing ω-3 polyunsaturated fatty acid has become attractive alternative sources to fish oil containing eicosapentaenoic acid or docosahexaenoic acid (DHA). We investigated whether ALA isolated from perilla oil has direct effects on improvement of cognitive ability and molecular mechanisms in APP processing in comparison with DHA...
November 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29080057/sex-differences-in-blood-hdl-c-the-total-cholesterol-hdl-c-ratio-and-palmitoleic-acid-are-not-associated-with-variants-in-common-candidate-genes
#17
Shannon L Klingel, Kaitlin Roke, Bertha Hidalgo, Stella Aslibekyan, Robert J Straka, Ping An, Michael A Province, Paul N Hopkins, Donna K Arnett, Jose M Ordovas, Chao-Qiang Lai, David M Mutch
Blood lipids are associated with cardiovascular disease (CVD) risk. Moreover, circulating lipid and fatty acid levels vary between men and women, and evidence demonstrates these traits may be influenced by single nucleotide polymorphisms (SNP). Sex-genotype interactions related to blood lipids and fatty acids have been poorly investigated and may help elucidate sex differences in CVD risk. The goal of this study was to investigate if the influence of SNPs previously associated with blood lipids and fatty acids varies in a sex-specific manner...
December 2017: Lipids
https://www.readbyqxmd.com/read/29071721/erythrocyte-membrane-fatty-acids-and-breast-cancer-risk-a-prospective-analysis-in-the-nurses-health-study-ii
#18
Kelly A Hirko, Boyang Chai, Donna Spiegelman, Hannia Campos, Maryam S Farvid, Susan E Hankinson, Walter C Willett, A Heather Eliassen
The roles of specific fatty acids in breast cancer etiology are unclear, particularly among premenopausal women. We examined 34 individual fatty acids, measured in blood erythrocytes collected between 1996-1999, and breast cancer risk in a nested case-control study of primarily premenopausal women in the Nurses' Health Study II. Breast cancer cases diagnosed after blood collection and before June 2010 (n=794) were matched to controls and conditional logistic regression was used to estimate OR's (95% CI's) for associations of fatty acids with breast cancer; unconditional logistic regression was used for stratified analyses...
October 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29071459/chemo-enzymatic-epoxidation-of-lallemantia-ibericaseed-oil-process-development-and-economic-ecological-evaluation
#19
Fabian Haitz, Sophia Radloff, S Rupp, M Fröhling, T Hirth, S Zibek
The chemo-enzymatic epoxidation of Lallemantia iberica seed oil (LISO), a novel plant oil characterized by its exceptional high content of alpha-linolenic acid (> 60%), was developed using an immobilized lipase from Pseudozyma antarctica and hydrogen peroxide as oxidant. A statistical approach was used to study the effect of enzyme amount, temperature, time, and solvent amount on the oxirane oxygen content obtained during epoxidation. An oxirane oxygen content of 8.6 ± 0.2% corresponding to a yield of 82% was obtained under optimized conditions that were identified to be at an enzyme load of 8...
October 25, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29051634/low-sat-structured-fats-enriched-in-%C3%AE-linolenic-acid-physicochemical-properties-and-crystallization-characteristics
#20
Marcella Aparecida Stahl, Monise Helen Masuchi Buscato, Renato Grimaldi, Lisandro Pavie Cardoso, Ana Paula Badan Ribeiro
This work sought to obtain and evaluate zero trans-fat reduced in saturated fatty acids, with higher content of unsaturated fatty acids. Palm oil (PO) was used as the reference of zero trans lipid base. Different amounts of linseed oil (LO) were added to PO, obtaining the following blends: 100:0; 80:20; 60:40; 40:60; 20:80 and 0:100 of PO:LO (w/w%), respectively. These blends were added to fully hydrogenated soybean oil (FHSO) as the crystallization modifying agent, and to sorbitan monostearate (SMS) as the structuring element, both at a proportion of 3% to build the structured fractions...
October 2017: Journal of Food Science and Technology
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