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Paul marik

Xavier Monnet, Paul E Marik, Jean-Louis Teboul
In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion does not always increase cardiac output as one expects. Thus, after the very initial phase and/or if fluid losses are not obvious, predicting fluid responsiveness should be the first step of fluid strategy. For this purpose, the central venous pressure as well as other "static" markers of preload has been used for decades, but they are not reliable...
December 2016: Annals of Intensive Care
Paul Marik, Edward Bittner, Douglas Hansell, Jennifer Sahatjian, Walter Linde-Zwirble
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Suchitra Ranjit, Rajeswari Natraj, Sathish Kumar Kandath, Niranjan Kissoon, Balasubramaniam Ramakrishnan, Paul E Marik
AIMS: We previously reported that vasodilatation was common in pediatric septic shock, regardless of whether they were warm or cold, providing a rationale for early norepinephrine (NE) to increase venous return (VR) and arterial tone. Our primary aim was to evaluate the effect of smaller fluid bolus plus early-NE versus the American College of Critical Care Medicine (ACCM) approach to more liberal fluid boluses and vasoactive-inotropic agents on fluid balance, shock resolution, ventilator support and mortality in children with septic shock...
October 2016: Indian Journal of Critical Care Medicine
Esmee Koeckhoven, Marike VAN DER Leeden, Leo D Roorda, Natasja M VAN Schoor, Paul Lips, Arjan DE Zwart, Joost Dekker, Martin VAN DER Esch, Willem F Lems
No abstract text is available yet for this article.
November 2016: Journal of Rheumatology
Paul E Marik
No abstract text is available yet for this article.
October 2016: Critical Care Medicine
Matthew McLaughlin, Paul E Marik
No abstract text is available yet for this article.
June 2016: Annals of Translational Medicine
Marike M van Beuge, Evert-Jan P M Ten Dam, Paul M N Werker, Ruud A Bank
BACKGROUND: Dupuytren's disease is a fibroproliferative disease of the hand and fingers, which usually manifests as two different phenotypes within the same patient. The disease first causes a nodule in the palm of the hand, while later, a cord develops, causing contracture of the fingers. RESULTS: We set out to characterize the two phenotypes by comparing matched cord and nodule tissue from ten Dupuytren's patients. We found that nodule tissue contained more proliferating cells, CD68-positive macrophages and α-smooth muscle actin (α-SMA)-positive myofibroblastic cells...
2016: Fibrogenesis & Tissue Repair
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Paul E Marik
No abstract text is available yet for this article.
July 2016: Critical Care Medicine
Paul E Marik
No abstract text is available yet for this article.
June 2016: Critical Care Medicine
Alexander Levitov, Heidi L Frankel, Michael Blaivas, Andrew W Kirkpatrick, Erik Su, David Evans, Douglas T Summerfield, Anthony Slonim, Raoul Breitkreutz, Susanna Price, Matthew McLaughlin, Paul E Marik, Mahmoud Elbarbary
OBJECTIVE: To establish evidence-based guidelines for the use of bedside cardiac ultrasound, echocardiography, in the ICU and equivalent care sites. METHODS: Grading of Recommendations, Assessment, Development and Evaluation system was used to rank the "levels" of quality of evidence into high (A), moderate (B), or low (C) and to determine the "strength" of recommendations as either strong (strength class 1) or conditional/weak (strength class 2), thus generating six "grades" of recommendations (1A-1B-1C-2A-2B-2C)...
June 2016: Critical Care Medicine
Esmee Koeckhoven, Marike van der Leeden, Leo D Roorda, Natasja M van Schoor, Paul Lips, Arjan de Zwart, Joost Dekker, Martin van der Esch, Willem F Lems
OBJECTIVE: Vitamin D deficiency, which is common among elderly people, has been linked to muscle weakness. In patients with knee osteoarthritis (OA), the association between muscle strength and serum 25-hydroxy Vitamin D [25(OH)D] level has not been studied comprehensively. The aim of our study was to examine the association between serum 25(OH)D level and muscle strength in patients with knee OA. METHODS: Data of the Amsterdam Osteoarthritis cohort from 319 participants with knee OA were used in a cross-sectional study...
July 2016: Journal of Rheumatology
Paul E Marik
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine
Fergus J Couch, Karoline B Kuchenbaecker, Kyriaki Michailidou, Gustavo A Mendoza-Fandino, Silje Nord, Janna Lilyquist, Curtis Olswold, Emily Hallberg, Simona Agata, Habibul Ahsan, Kristiina Aittomäki, Christine Ambrosone, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Monica Barile, Rosa B Barkardottir, Daniel Barrowdale, Lars Beckmann, Matthias W Beckmann, Javier Benitez, Stephanie V Blank, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S Buys, Trinidad Caldes, Maria A Caligo, Federico Canzian, Jane Carpenter, Jenny Chang-Claude, Stephen J Chanock, Wendy K Chung, Kathleen B M Claes, Angela Cox, Simon S Cross, Julie M Cunningham, Kamila Czene, Mary B Daly, Francesca Damiola, Hatef Darabi, Miguel de la Hoya, Peter Devilee, Orland Diez, Yuan C Ding, Riccardo Dolcetti, Susan M Domchek, Cecilia M Dorfling, Isabel Dos-Santos-Silva, Martine Dumont, Alison M Dunning, Diana M Eccles, Hans Ehrencrona, Arif B Ekici, Heather Eliassen, Steve Ellis, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Asta Försti, Florentia Fostira, William D Foulkes, Tara Friebel, Eitan Friedman, Debra Frost, Marike Gabrielson, Marilie D Gammon, Patricia A Ganz, Susan M Gapstur, Judy Garber, Mia M Gaudet, Simon A Gayther, Anne-Marie Gerdes, Maya Ghoussaini, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Jacek Gronwald, Pascal Guénel, Marc Gunter, Lothar Haeberle, Christopher A Haiman, Ute Hamann, Thomas V O Hansen, Steven Hart, Sue Healey, Tuomas Heikkinen, Brian E Henderson, Josef Herzog, Frans B L Hogervorst, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Keith Humphreys, David J Hunter, Tomasz Huzarski, Evgeny N Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul James, Ramunas Janavicius, Uffe Birk Jensen, Esther M John, Michael Jones, Maria Kabisch, Siddhartha Kar, Beth Y Karlan, Sofia Khan, Kay-Tee Khaw, Muhammad G Kibriya, Julia A Knight, Yon-Dschun Ko, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Ava Kwong, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Eunjung Lee, Loic Le Marchand, Jenny Lester, Annika Lindblom, Noralane Lindor, Sara Lindstrom, Jianjun Liu, Jirong Long, Jan Lubinski, Phuong L Mai, Enes Makalic, Kathleen E Malone, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Frederik Marme, John W M Martens, Lesley McGuffog, Alfons Meindl, Austin Miller, Roger L Milne, Penelope Miron, Marco Montagna, Sylvie Mazoyer, Anna M Mulligan, Taru A Muranen, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Børge G Nordestgaard, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Ana Osorio, Sue K Park, Petra H Peeters, Bernard Peissel, Paolo Peterlongo, Julian Peto, Catherine M Phelan, Robert Pilarski, Bruce Poppe, Katri Pylkäs, Paolo Radice, Nazneen Rahman, Johanna Rantala, Christine Rappaport, Gad Rennert, Andrea Richardson, Mark Robson, Isabelle Romieu, Anja Rudolph, Emiel J Rutgers, Maria-Jose Sanchez, Regina M Santella, Elinor J Sawyer, Daniel F Schmidt, Marjanka K Schmidt, Rita K Schmutzler, Fredrick Schumacher, Rodney Scott, Leigha Senter, Priyanka Sharma, Jacques Simard, Christian F Singer, Olga M Sinilnikova, Penny Soucy, Melissa Southey, Doris Steinemann, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Anthony Swerdlow, Csilla I Szabo, Rulla Tamimi, William Tapper, Manuel R Teixeira, Soo-Hwang Teo, Mary B Terry, Mads Thomassen, Deborah Thompson, Laima Tihomirova, Amanda E Toland, Robert A E M Tollenaar, Ian Tomlinson, Thérèse Truong, Helen Tsimiklis, Alex Teulé, Rosario Tumino, Nadine Tung, Clare Turnbull, Giski Ursin, Carolien H M van Deurzen, Elizabeth J van Rensburg, Raymonda Varon-Mateeva, Zhaoming Wang, Shan Wang-Gohrke, Elisabete Weiderpass, Jeffrey N Weitzel, Alice Whittemore, Hans Wildiers, Robert Winqvist, Xiaohong R Yang, Drakoulis Yannoukakos, Song Yao, M Pilar Zamora, Wei Zheng, Per Hall, Peter Kraft, Celine Vachon, Susan Slager, Georgia Chenevix-Trench, Paul D P Pharoah, Alvaro A N Monteiro, Montserrat García-Closas, Douglas F Easton, Antonis C Antoniou
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array...
April 27, 2016: Nature Communications
Paul E Marik, Michael H Hooper
No abstract text is available yet for this article.
April 2016: Intensive Care Medicine
Armand R J Girbes, René Robert, Paul E Marik
No abstract text is available yet for this article.
April 2016: Intensive Care Medicine
Paul E Marik
PURPOSE OF REVIEW: Anorexia is a preserved evolutionally response that may be beneficial during acute illness. Yet current clinical practice guidelines recommend early and targeted enteral nutritional support. However, the optimal timing of the initiation of enteral nutrition and the caloric and protein requirements of critically ill patients is controversial. RECENT FINDINGS: Starvation promotes autophagy and this may play a key role in promoting host defenses and the immune response to intracellular pathogens...
March 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Preben G Berthelsen, Paul E Marik
No abstract text is available yet for this article.
December 31, 2015: New England Journal of Medicine
Evert-Jan P M Ten Dam, Marike M van Beuge, Ruud A Bank, Paul M N Werker
Genetic background plays an important role in the development of Dupuytren's disease. A genome-wide association study (GWAS) showed that nine loci are associated with the disease, six of which contain genes that are involved in Wnt signaling (WNT2, WNT4, WNT7B, RSPO2, SFRP4, SULF1). To obtain insight in the role of these genes, we performed expression studies on affected and unaffected patient's tissues. Surgically obtained nodules and cords from eight Dupuytren's patients were compared to patient-matched control tissue (unaffected transverse palmar fascia)...
March 2016: Journal of Cell Communication and Signaling
Paul E Marik, Rodrigo Cavallazzi
BACKGROUND: Patients who have had an unprovoked deep venous thrombosis (DVT) or pulmonary embolus (PE) are at a high risk for recurrent venous thromboembolism (VTE). Extended "life-long" anticoagulation has been recommended in these patients. However, the risk benefit ratio of this approach is controversial and the role of the direct oral anticoagulants (DOACs) and aspirin is unclear. Furthermore, in some patients with a "weak provoking factor" there is clinical equipoise regarding continuation or cessation of anticoagulant therapy after treatment of the acute VTE event...
2015: PloS One
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