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Royal Dutch Association for the Advancement of Pharmacy

J J Swen, M Nijenhuis, A de Boer, L Grandia, A H Maitland-van der Zee, H Mulder, G A P J M Rongen, R H N van Schaik, T Schalekamp, D J Touw, J van der Weide, B Wilffert, V H M Deneer, H-J Guchelaar
Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL)...
May 2011: Clinical Pharmacology and Therapeutics
Matthijs L Becker, Loes E Visser, Teun van Gelder, Albert Hofman, Bruno H Ch Stricker
BACKGROUND: Drug-drug interactions (DDIs) are responsible for a variety of adverse reactions, particularly in an elderly population. OBJECTIVE: To assess the frequency and potential clinical relevance of DDIs in a population aged > or = 55 years. METHODS: Exposure to DDIs was assessed in 7842 people participating in the Rotterdam Study, a population-based cohort study. These people were followed between 1 January 1992 and 1 July 2005. The DDI list of the Royal Dutch Association for the Advancement of Pharmacy, in which DDIs are categorized by potential clinical relevance and quality of evidence, was used...
2008: Drugs & Aging
Eric N van Roon, Sander Flikweert, Marianne le Comte, Pim N J Langendijk, Wilma J M Kwee-Zuiderwijk, Paul Smits, Jacobus R B J Brouwers
INTRODUCTION: Computerised drug interaction surveillance systems (CIS) may be helpful in detecting clinically significant drug interactions. Experience with CIS reveals that they often yield alerts with questionable clinical significance, fail to provide relevant information on risk factors for the adverse reaction of the interaction and fail to detect all significant drug interactions. These problems highlight the importance of transparency and selectivity in choosing the drug interactions to be included in CIS...
2005: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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