keyword
https://read.qxmd.com/read/38486764/study-on-the-mechanism-of-shugan-lidan-xiaoshi-granule-in-preventing-acute-pancreatitis-based-on-network-pharmacology-and-molecular-docking
#1
JOURNAL ARTICLE
Jiaxing Wang, Yang Wang, Zitong Chen, Bin Liu, Wujie Wang, Yuliang Li
BACKGROUND: Shugan Lidan Xiaoshi granules (SLXG) is a herbal granule formulation developed by extensively modifying multiple traditional Chinese medicine compound prescriptions known for their ability to dissolve stones. It is primarily used for the prevention and treatment of cholelithiasis and possesses significant therapeutic potential in both preventing and treating acute pancreatitis. However, the preventive effects of SLXG on cholelithiasis-related complications, such as acute pancreatitis (AP), have been inadequately researched...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38430176/mechanism-of-action-of-astragali-radix-cassia-twig-poria-in-chronic-heart-failure-a-network-pharmacology-approach
#2
JOURNAL ARTICLE
Jinxuan Wei, Suzhen Yang, Zhimin Zhang, Liang Kang, Yihua Li, Liwen Lin, Xinjun Zhao, Rong Li
This study utilizes network pharmacology analysis to investigate the components, targets, and pathways involved in the treatment of chronic heart failure (CHF) with the combination of "Astragali Radix-Cassia Twig-Poria." The TCMSP, GeneCards, OMIM, PharmGkb, TTD, and DrugBank databases were utilized to identify the active ingredients and targets of this combination for CHF. Protein interactions were derived from the STRING database, and Cytoscape was used to construct the "drug-component-target-disease" network and protein interactions network...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38404557/the-effect-of-astragali-radix-radix-angelica-sinensis-on-acute-kidney-injury-a-network-pharmacology-and-molecular-docking-study
#3
JOURNAL ARTICLE
Qin Wang, Wenrui Zhen, Giuseppe Lippi, Qi Liu
BACKGROUND: Acute kidney injury (AKI) is a devastating clinical syndrome with high mortality rate attributed to lack of effective treatment. The herbal pair of Astragali Radix (AR) and Radix Angelica Sinensis (RAS) is a commonly prescribed herbal formula or is added to other traditional Chinese medicine (TCM) prescriptions for the treatment of kidney diseases. AR-RAS has certain protective effects on AKI in experiments, but the relevant mechanisms have yet to be clear. So this study aims to explore the mechanism of action of AR-RAS in AKI by combining network pharmacology and molecular docking methods...
January 31, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38388174/pillharmonics%C3%A2-an-orchestrated-pharmacogenetics-medication-clinical-decision-support-service
#4
JOURNAL ARTICLE
Robert H Dolin, Edna C Shenvi, Carla Alvarez, Randolph Barrows, Aziz Boxwala, Benson Lee, Brian Nathanson, Yelena Kleyner, Rachel Hagemann, Tonya Hongsermeier, Joan Kapusnik-Uner, Adnan Lakdawala, James Shalaby
OBJECTIVES: Pharmacogenetics (PGx) is increasingly important in individualizing therapeutic management plans, but is often implemented apart from other types of medication clinical decision support (CDS). The lack of integration of pharmacogenetics into existing CDS may result in incomplete interaction information, which may pose patient safety concerns. We sought to develop a cloud-based orchestrated medication CDS service that integrates PGx with a broad set of drug screening alerts and evaluate it through a clinician utility study...
February 22, 2024: Applied Clinical Informatics
https://read.qxmd.com/read/38372412/pharmacogenetic-considerations-in-therapy-with-novel-antiplatelet-and-anticoagulant-agents
#5
JOURNAL ARTICLE
Anthony Yazbeck, Reem Akika, Zainab Awada, Nathalie K Zgheib
Antiplatelets and anticoagulants are extensively used in cardiovascular medicine for the prevention and treatment of thrombosis in the venous and arterial circulations. Wide inter-individual variability has been observed in response to antiplatelets and anticoagulants, which triggered researchers to investigate the genetic basis of this variability. Data from extensive pharmacogenetic studies pointed to strong evidence of association between polymorphisms in candidate genes and the pharmacokinetics and pharmacodynamic action and clinical response of the antiplatelets clopidogrel and the anticoagulant warfarin...
February 19, 2024: Pharmacogenetics and Genomics
https://read.qxmd.com/read/38363936/elucidation-of-the-mechanism-of-zhenbao-pills-for-the-treatment-of-spinal-cord-injury-by-network-pharmacology-and-molecular-docking-a-review
#6
REVIEW
Mengru Xu, Wenwen Zhang, Sheng Xu, Xiaochen Niu, Li Wang, Xiaohui Wang, Haihu Hao
To explore the mechanism of the Zhenbao pill (ZBP) in treating spinal cord injury (SCI). The TCMSP Database, HERB Database and literature search were used to screen the effective ingredients and targets of ZBP; SCI-related genes were searched in GeneCards, OMIM, PharmGkb, TTD and DrugBank databases; the potential targets of ZBP for treating SCI were predicted and Venn diagrams were drawn, and the "herb-ingredient-target" network was constructed by Cytoscape software. The PPI network was constructed by STRING software, and the core targets were screened by cytoNCA plug-in; GO enrichment and KEGG pathway analysis were performed on the predicted targets using the DAVID Platform, and visualized with the Microbiology Network Platform...
February 16, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38347958/a-comprehensive-study-to-investigate-the-tumor-suppressive-role-of-radix-bupleuri-on-gastric-cancer-with-network-pharmacology-and-molecular-docking
#7
JOURNAL ARTICLE
Long Lv, Jinghu Du, Daorong Wang, Zeqiang Yan
BACKGROUND: Gastric cancer (GC) is a common fatal malignancy. The aim of this study was to explore and validate the tumor-suppressive role and mechanism of Radix Bupleuri in GC. METHODS: The active constituents of Radix Bupleuri were screened using TCMSP database. SwissTargetPrediction database was used to predict potential target genes of the compounds. GeneCards, TTD, DisGeNET, OMIM, and PharmGKB databases were used to search for GC-related targets. STRING database and Cytoscape 3...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38341366/exploring-the-impact-of-pharmacogenetics-on-personalized-medicine-a-systematic-review
#8
REVIEW
Laura Amaro-Álvarez, Jaime Cordero-Ramos, Miguel Ángel Calleja-Hernández
INTRODUCTION: Pharmacogenetics evaluates how genetic variations influence drug responses. Nowadays, genetic tests have advanced, becoming more affordable, and its integration is supported by stronger clinical evidence. Guidelines such as those from CPIC (Clinical Pharmacogenetics Implementation Consortium) and resources like PharmGKB facilitate genotype-based prescribing; and organizations like the FDA promote genetic testing before initiating certain medications. Preventive pharmacogenetic panels seem promising, but further research on biomarkers and diverse populations is needed...
February 9, 2024: Farmacia Hospitalaria
https://read.qxmd.com/read/38318502/systematic-pharmacology-and-experimental-validation-to-reveal-the-alleviation-of-astragalus-membranaceus-regulating-ferroptosis-in-osteoarthritis
#9
JOURNAL ARTICLE
Kai Chen, Yaohui Yu, Yishu Wang, Yi Zhu, Chaoren Qin, Jintao Xu, Xiangjie Zou, Tianqi Tao, Yang Li, Yiqiu Jiang
BACKGROUND: Astragalus membranaceus (AM) shows promise as a therapeutic agent for osteoarthritis (OA), a debilitating condition with high disability rates. OA exacerbation is linked to chondrocyte ferroptosis, yet the precise pharmacological mechanisms of AM remain unclear. METHODS: We validated AM's protective efficacy in an anterior cruciate ligament transection (ACLT) mouse model of OA. The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database was utilized to identify AM's active components and their targets...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38308569/use-of-drugs-with-pharmacogenomics-pgx-based-dosing-guidelines-in-a-danish-cohort-of-persons-with-chronic-kidney-disease-both-on-dialysis-and-not-on-dialysis-perspectives-for-prescribing-optimization
#10
JOURNAL ARTICLE
Niels Westergaard, Morten Baltzer Houlind, Lona Louring Christrup, Helle Gybel Juul-Larsen, Charlotte Strandhave, Anne Estrup Olesen
AIM: The objective of this registry study is to assess the utilization of pharmacogenomic (PGx) drugs among patients with chronic kidney disease (CKD). METHODS: This study was a retrospective study of patients affiliated with the Department of Nephrology, Aalborg University Hospital, Denmark in 2021. Patients diagnosed with CKD were divided into CKD without dialysis and CKD with dialysis. PGx prescription drugs were retrieved from the Patient Administration System...
February 3, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38300251/the-landscape-of-very-important-pharmacogenes-variants-and-potential-clinical-relevance-in-the-chinese-jingpo-population-a-comparative-study-with-worldwide-populations
#11
JOURNAL ARTICLE
Xiaoya Ma, Yujie Li, Xufeng Zang, Jinping Guo, Wenqian Zhou, Junhui Han, Jing Liang, Panpan Wan, Hua Yang, Tianbo Jin
BACKGROUND: Pharmacogenomics is a facet of personalized medicine that explores how genetic variants affect drug metabolism and adverse drug reactions. Therefore, this study aims to detect distinct pharmacogenomic variations among the Jingpo population and explore their clinical correlation with drug metabolism and toxicity. METHODS: Agena MassARRAY Assay was used to genotype 57 VIP variants in 28 genes from 159 unrelated Jingpo participants. Subsequently, the chi-squared test and Bonferroni's statistical tests were utilized to conduct a comparative analysis of genotypes and allele frequencies between the Jingpo population and the other 26 populations from the 1000 Genome Project...
February 1, 2024: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/38288577/psychiatric-level-1a-evidence-pharmacogenomics-in-a-brazilian-admixed-cohort-and-global-populations
#12
JOURNAL ARTICLE
Helena Pereira Ribeiro, Beatriz Meza Baraldi, Fernanda Rodrigues-Soares, Aline Cristiane Planello
Purpose: To compare minor allele frequencies (MAFs) of psychiatric drug response variants in a Brazilian admixed cohort with global populations and other Brazilian groups. Methods: PharmGKB MAFs were gathered from publicly available genetic datasets for Brazil and worldwide. Results: Among 146 variants in CYP2D6 and CYP2C19 , 41 were present in Brazil, mostly rare (MAF <1%). 11 variants showed significant MAF differences with large effect sizes compared with global populations. CYP2C19*3 (rs4986893), CYP2C19*17 (rs12248560), CYP2D6*17 (rs28371706-A) and CYP2D6*29 (rs61736512) exhibited higher frequencies in Brazil, with the latter three also differing from other Brazilian groups...
January 30, 2024: Pharmacogenomics
https://read.qxmd.com/read/38233388/pharmacogenomic-biomarker-information-on-drug-labels-of-the-spanish-agency-of-medicines-and-sanitary-products-evaluation-and-comparison-with-other-regulatory-agencies
#13
JOURNAL ARTICLE
María Estévez-Paredes, M Carmen Mata-Martín, Fernando de Andrés, Adrián LLerena
This work aimed to analyse the pharmacogenetic information in the Spanish Drug Regulatory Agency (AEMPS) Summary of Products Characteristics (SmPC), evaluating the presence of pharmacogenetic biomarkers, as well as the associated recommendations. A total of 55.4% of the 1891 drug labels reviewed included information on pharmacogenetic biomarker(s). Pharmacogenomic information appears most frequently in the "antineoplastic and immunomodulating agents", "nervous system", and "cardiovascular system" Anatomical Therapeutic Chemical groups...
January 17, 2024: Pharmacogenomics Journal
https://read.qxmd.com/read/38230665/pharmacogenetic-and-pharmacogenomic-treatment-of-rheumatoid-arthritis-a-review-of-pharmacogenomics-knowledge-base-scientific-evidence
#14
EDITORIAL
Pedro Dorado, Eva M Peñas-Lledó
Tweetable abstract Update on the genetic variants with the highest level of Pharmacogenomics Knowledge Base evidence for their association with toxicity and efficacy in response to the most commonly used disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis.
January 17, 2024: Pharmacogenomics
https://read.qxmd.com/read/38223704/qiditangshen-granules-alleviates-diabetic-nephropathy-podocyte-injury-a-network-pharmacology-study-and-experimental-validation-in-vivo-and-vitro
#15
JOURNAL ARTICLE
Fei Gao, Ying Zhou, Borui Yu, Huidi Xie, Yang Shi, Xianhui Zhang, Hongfang Liu
BACKGROUND: QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration. METHODS: According to the active ingredients and targets of the QDTS in the TCMSP database, the network pharmacology of QDTS was investigated. The potential active ingredients were chosen based on the oral bioavailability and the drug similarity index...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38218503/study-on-the-effects-and-mechanisms-of-wenzhong-bushen-formula-in-improving-ovarian-reserve-decline-in-mice-based-on-network-pharmacology
#16
JOURNAL ARTICLE
Xiaoxia Liang, Haibo Xie, Leyi Yu, Jiahui Ouyang, Qingjie Peng, Keming Chen, Feifei Liu, Hua Chen, Xiaojiang Chen, Xiaoli Du, Xiangdong Zhu, Guangyong Li, Rui He
ETHNOPHARMACOLOGICAL RELEVANCE: The Wenzhong Bushen Formula (WZBSF) is a traditional Chinese medicine empirical formula known for its effects in tonifying qi, strengthening the spleen, warming the kidneys, promoting yang, regulating blood circulation, and balancing menstruation. Clinical evidence has demonstrated its significant efficacy in treating Diminished Ovarian Reserve (DOR) by improving ovarian reserves. However, the specific pharmacological mechanisms of WZBSF remain unclear...
January 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38215128/exploring-the-potential-mechanism-and-molecular-targets-of-taohong-siwu-decoction-against-deep-vein-thrombosis-based-on-network-pharmacology-and-analysis-docking
#17
JOURNAL ARTICLE
Wei Fan, Jinhui Liu, Qingyan Liu
This study aims to investigate the mechanism of Taohong Siwu Decoction (THSWD) against deep vein thrombosis (DVT) using network pharmacology and molecular docking technology. We used the Traditional Chinese Medicine Systems Pharmacology database and reviewed literature to identify the main chemical components of THSWD. To find targets for DVT, we consulted GeneCards, Therapeutic Target Database, and PharmGKB databases. We used Cytoscape 3.8.2 software to construct herb-disease-gene-target networks. Additionally, we integrated drug targets and disease targets on the STRING platform to create a protein-protein interaction network...
January 12, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38188548/molecular-mechanism-of-xuebijing-in-treating-pyogenic-liver-abscess-complicated-with-sepsis
#18
JOURNAL ARTICLE
Wei Zhou, Maiying Fan, Xiang Li, Fang Yu, En Zhou, Xiaotong Han
BACKGROUND: Xuebijing (XBJ) can alleviate the inflammatory response, improve organ function, and shorten the intensive care unit (ICU) stay in patients with pyogenic liver abscess (PLA) complicated with sepsis, but the molecular mechanisms have not been elucidated. This study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology approach. METHODS: The active ingredients and targets of XBJ were retrieved from the ETCM database...
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/38174416/investigating-the-mechanism-of-sinisan-formula-in-depression-treatment-a-comprehensive-analysis-using-geo-datasets-network-pharmacology-and-molecular-docking
#19
JOURNAL ARTICLE
Meiling Zheng, Xinxing Yang, Ping Yuan, Feiyan Wang, Xiaodi Guo, Long Li, Jin Wang, Shan Miao, Xiaopeng Shi, Shanbo Ma
The herbal formula Sinisan (SNS) is a commonly used treatment for depression; however, its mechanism of action remains unclear. This article uses a combination of the GEO database, network pharmacology and molecular docking technologies to investigate the mechanism of action of SNS. The aim is to provide new insights and methods for future depression treatments. The study aims to extract effective compounds and targets for the treatment of depression from the T CMSP database. Relevant targets were searched using the GEO, Disgenet, Drugbank, PharmGKB and T T D databases, followed by screening of core targets...
January 4, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38159844/complete-genomic-profiles-of-1-496-taiwanese-reveal-curated-medical-insights
#20
JOURNAL ARTICLE
Jacob Shujui Hsu, Dung-Chi Wu, Shang-Hung Shih, Jen-Feng Liu, Ya-Chen Tsai, Tung-Lin Lee, Wei-An Chen, Yi-Hsuan Tseng, Yi-Chung Lo, Hong-Ye Lin, Yi-Chieh Chen, Jing-Yi Chen, Ting-Hsuan Chou, Darby Tienhao Chang, Ming Wei Su, Wei-Hong Guo, Hsin-Hsiang Mao, Chien-Yu Chen, Pei-Lung Chen
INTRODUCTION: The population of Taiwan has a long history of ethno-cultural evolution. The Taiwanese population was isolated from other large populations such as the European, Han Chinese, and Japanese population. The Taiwan Biobank (TWB) project has built a nationwide database, particularly for personal whole-genome sequence (WGS) to facilitate basic and clinical collaboration nationally and internationally, making it one of the most valuable public datasets of the East Asian population...
December 28, 2023: Journal of Advanced Research
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