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https://www.readbyqxmd.com/read/28209683/evaluation-of-6-remote-first-nations-community-based-buprenorphine-programs-in-northwestern-ontario-retrospective-study
#1
Solomon Mamakwa, Meldon Kahan, Dinah Kanate, Mike Kirlew, David Folk, Sharon Cirone, Sara Rea, Pierre Parsons, Craig Edwards, Janet Gordon, Fiona Main, Len Kelly
OBJECTIVE: To evaluate established opioid addiction treatment programs that use traditional healing in combination with buprenorphine-naloxone maintenance treatment in 6 First Nations communities in the Sioux Lookout region of northwestern Ontario. DESIGN: Retrospective cohort study. SETTING: Six First Nations communities in northwestern Ontario. PARTICIPANTS: A total of 526 First Nations participants in opioid-dependence treatment programs...
February 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28209132/urinary-tract-infection-among-fistula-patients-admitted-at-hamlin-fistula-hospital-addis-ababa-ethiopia
#2
Matifan Dereje, Yimtubezinesh Woldeamanuel, Daneil Asrat, Fekade Ayenachew
BACKGROUND: Urinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia...
February 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28204701/cost-and-efficacy-assessment-of-an-alternative-medication-compliance-urine-drug-testing-strategy
#3
Kelly Doyle, Frederick G Strathmann
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28201761/evaluation-of-an-automated-reader-and-color-interpretation-based-immunoassays-for-multiplexed-drug-of-abuse-testing-in-urine
#4
Seon Young Kim, Hyunjin Kim, Yeongchun Park, Jinsook Lim, Jimyung Kim, Sun Hoe Koo, Gye Cheol Kwon
No abstract text is available yet for this article.
February 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28197332/escitalopram-induced-amenorrhea-and-false-positive-urine-pregnancy-test
#5
Vithyalakshmi Selvaraj, Siv Hour, Palanikumar Gunasekar, Caron Gray, James F Smith
Escitalopram is a selective serotonin reuptake inhibitor antidepressant approved by the Food and Drug Administration for the treatment of major depressive disorder and generalized anxiety disorder. A 34-year-old female patient with major depressive disorder developed amenorrhea and had a false-positive urine pregnancy test after initiation of escitalopram treatment. To our knowledge, no published case report of amenorrhea and false-positive urine pregnancy tests in women taking escitalopram exists. This case report suggests that women of child-bearing age should be carefully monitored for amenorrhea while they are on an antidepressant treatment regimen...
January 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28193352/a-straightforward-validated-liquid-chromatography-coupled-to-tandem-mass-spectrometry-method-for-the-simultaneous-detection-of-nine-drugs-of-abuse-and-their-metabolites-in-hair-and-nails
#6
Delphine Cappelle, Mireille De Doncker, Celine Gys, Kamelia Krysiak, Steven De Keukeleire, Walid Maho, Cleo L Crunelle, Geert Dom, Adrian Covaci, Alexander L N van Nuijs, Hugo Neels
Hair and nails allow for a stable accumulation of compounds over time and retrospective investigation of past exposure and/or consumption. Owing to their long window of detection (weeks to months), analysis of these matrices can provide information complementary to blood and urine analysis or can be used in standalone when e.g. elimination from the body has already occurred. Drugs of abuse are often used together and, therefore, multi-analyte methods capable of detecting several substances and their metabolites in a single run are of importance...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28192722/a-preliminary-longitudinal-study-of-white-matter-alteration-in-cocaine-use-disorder-subjects
#7
Liangsuo Ma, Joel L Steinberg, Qin Wang, Joy M Schmitz, Edward L Boone, Ponnada A Narayana, F Gerard Moeller
BACKGROUND: Previous diffusion tensor imaging (DTI) studies have consistently shown that subjects with cocaine use disorder (CocUD) had altered white matter microstructure in the corpus callosum. It is believed that these alterations are due to preexisting factors, chronic cocaine use, or both. However, there is no published longitudinal DTI study on human cocaine users yet which could shed light on the relationship between cocaine use and DTI findings. METHODS: This study used a longitudinal design and DTI to test if the white matter microstructure shows quicker alteration in CocUD subjects than controls...
January 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28188298/comparison-between-radioanalysis-and-19-f-nuclear-magnetic-resonance-spectroscopy-in-the-determination-of-mass-balance-metabolism-and-distribution-of-pefloxacin
#8
Haitao Hu, Kishore Kumar Katyayan, Boris A Czeskis, Everett J Perkins, Palaniappan Kulanthaivel
Mass balance and metabolism studies using radiolabeled substances are well recognized as an important part of the drug development process. Herein, we directly assessed the use of (19)F NMR to achieve quantitative mass balance, metabolism and distribution information for fluorinated compounds without the need for radiolabeled synthesis/study. As a test case, the disposition of pefloxacin, a fluoroquinolone antibiotic, was evaluated in rats using quantitative (19)F NMR in parallel with a radiolabeled study. Urine, bile, and feces samples were collected over specific periods following oral administration of either 25 mg/kg [(14)C]pefloxacin or 25 mg/kg pefloxacin and were subsequently profiled by radioactivity or (19)F NMR, respectively...
February 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28179246/legionella-pneumophila-pneumonia-possibly-due-to-ustekinumab-therapy-in-a-patient-with-crohn-s-disease
#9
Joaquín Borrás-Blasco, Xavier Cortes, Sergio Fernandez-Martinez, Elvira Casterá, Beatriz Antequera
PURPOSE: A case report of Legionella pneumophila pneumonia associated with off-label use of ustekinumab in a patient with Crohn's disease (CD) is presented. SUMMARY: A 57-year-old man with longstanding CD was hospitalized with a four-day history of fever (38.5 °C), dyspnea, left pleuritic pain, and weight loss (more than 6 kg) about six weeks after beginning treatment with ustekinumab, a human monoclonal antibody approved in the United States for two indications (plaque psoriasis and psoriatic arthritis) and currently under investigation as a potential treatment for CD and other inflammatory disorders...
February 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28178895/repetitive-urine-and-blood-sampling-in-neonatal-and-weaned-piglets-for-pharmacokinetic-and-pharmacodynamic-modelling-in-drug-discovery-a-pilot-study
#10
Elke Gasthuys, Stijn Schauvliege, Thomas van Bergen, Joske Millecam, Ilaria Cerasoli, Ann Martens, Frank Gasthuys, Tim Vandecasteele, Pieter Cornillie, Wim Van den Broeck, Filip Boyen, Siska Croubels, Mathias Devreese
Piglets are considered to be suitable animal models for predicting the pharmacokinetics and pharmacodynamics (PK/PD) of test drugs for potential use in the paediatric population. Such PK/PD studies require multiple blood and urine samplings. The goal of the present study was to determine a suitable blood collection strategy applicable in the youngest age categories of six days, four weeks and eight weeks of age, as well as a urine collection technique for male piglets in the same age categories. Blood was collected either by a surgically-placed jugular vein catheter (six days old [ n = 4] and four weeks old [ n = 2] piglets) or by direct venepuncture of the jugular vein (four weeks old [ n = 2] and eight weeks old [ n = 4] piglets)...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28176545/rapid-quantification-of-free-and-glucuronidated-thccooh-in-urine-using-coated-well-plates-and-lc-ms-ms-analysis
#11
Marianne Hädener, Wolfgang Weinmann, Dave R van Staveren, Stefan König
AIM: Generally, urine drug testing for cannabis abuse involves measuring total concentrations of 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THCCOOH) obtained by enzymatic and/or alkaline hydrolysis of THCCOOH-glucuronide. As hydrolysis can be inconsistent and incomplete, direct measurement of the two metabolites is preferable. Methodology & results: We developed a high-throughput LC-MS/MS method for simultaneous quantification of free and glucuronidated THCCOOH in urine using coated 96-well plates for analyte extraction and column-switching chromatography...
February 8, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28176511/prevalence-of-illicit-drug-use-at-the-end-of-pregnancy-a-cross-sectional-study-at-the-time-of-birth
#12
Amadeu Roca Comas, Joan S Vila Domènech, Joana Massa Solé, Patricia Timoneda Paz, Mar Peñas Boira, Francisco J Herrero Espinet, Josep Sánchez Jiménez, Anna Ballester Martínez
BACKGROUND: Drug use during pregnancy is associated with adverse perinatal outcomes. This study was conducted to assess the prevalence of consumption of drugs of abuse in pregnant women at the end of gestation. METHODS: Cross-sectional study of all consecutive pregnant women in labor admitted to a regional hospital in Calella (Barcelona, Spain) in labor over one year period (2014- 2015). Women who gave written consent to take part in the study provided a urine sample on admission and completed a questionnaire with toxic habits-related questions...
February 7, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28169975/simple-urine-test-to-evaluate-adherence-to-oral-5-asa-in-teenagers-with-ulcerative-colitis-proof-of-concept
#13
Alie Dijkstra, Daan J Touw, Patrick F van Rheenen
OBJECTIVES: 5-aminosalicylic acid (5-ASA) is an important maintenance drug for patients with ulcerative colitis. A proportion of the ingested dose is excreted in the urine. Measuring 5-ASA and its metabolites in urine requires mass spectrometry, which is not widely available for this purpose. Urinary 5-ASA can be measured by colorimetry using the serum salicylic acid assay and is a surrogate marker of recent 5-ASA ingestion. We evaluated whether measuring 5-ASA in first morning voids or in random spot urine samples correctly identifies teenagers with poor adherence to oral 5-ASA...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28162502/-265-institutional-policy-development-and-urine-drug-testing-in-a-multidisciplinary-functional-pain-program-a-retrospective-analysis
#14
B Marshall, C Zeigler, J Atchison
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28157591/higher-prevalence-of-detectable-troponin-i-among-cocaine-users-without-known-cardiovascular-disease
#15
Elise D Riley, Priscilla Y Hsue, Eric Vittinghoff, Alan H B Wu, Phillip O Coffin, Peter K Moore, Kara L Lynch
BACKGROUND: While cocaine use is an established risk factor for acute cardiovascular complications, associations between cocaine use and markers of cardiac injury outside of acute hospital presentation remain poorly characterized. We leveraged advances in cardiac troponin (cTnI) testing to assess low but clinically meaningful levels of cardiac injury among cocaine users and non-users. METHODS: We conducted a case control study comparing cTnI levels by the presence of cocaine among patients presenting for non-cardiac care in an urban safety net hospital...
January 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28157415/high-concomitant-misuse-of-fentanyl-in-subjects-on-opioid-maintenance-treatment
#16
Daniela Krause, Diana Plörer, Gabriele Koller, Gabi Martin, Catja Winter, Roland Adam, Minavere Canolli, Jori Al-Iassin, Rainer Musselmann, Stephan Walcher, Frank Schäfer, Oliver Pogarell
BACKGROUND: Concomitant opioid misuse is an increasing problem in opioid maintenance treatment as it interferes with treatment success. OBJECTIVE: Therefore, the rates of concomitant fentanyl misuse in opioid maintained patients were investigated. METHODS: We conducted a cross-sectional study which consisted in collecting data via urine samples and questionnaires in Germany. Urine samples of patients on opioid maintenance treatment were gathered and fentanyl concentrations were measured from 2008 to 2012...
February 3, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28156453/frequency-predictors-and-outcomes-of-urine-drug-test-among-patients-with-advanced-cancer-on-chronic-opioid-therapy-at-an-outpatient-supportive-care-clinic
#17
Tonya Edwards, David Hui, Jessica Marie Waletich-Flemming, Suresh K Reddy, Diane D Liu, Jimin Wu, Eduardo Bruera
: 94 Background: Data on the utilization and outcomes of urine drug tests (UDT) among advanced cancer patients is limited. The main objective of this study was to determine the factors associated with UDT ordering and results in advanced cancer outpatients. METHODS: A retrospective chart review of 1058 patients seen from March 2014 to November 2015 at an outpatient supportive care clinic was conducted. Sixty-one patients on chronic opioid therapy who underwent UDT were identified...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155015/nitrofurantoin-safety-and-effectiveness-in-treating-acute-uncomplicated-cystitis-auc-in-hospitalized-adults-with-renal-insufficiency-antibiotic-stewardship-implications
#18
B A Cunha, C B Cunha, B Lam, J Giuga, J Chin, V F Zafonte, S Gerson
Nitrofurantoin remains a key oral antibiotic stewardship program (ASP) option in the treatment of acute uncomplicated cystitis (AUC) due to multi-drug resistant (MDR) Gram negative bacilli (GNB). However, there have been concerns regarding decreased nitrofurantoin efficacy with renal insufficiency. In our experience over the past three decades, nitrofurantoin has been safe and effective in treating AUC in hospitalized adults with renal insufficiency. Accordingly, we retrospectively reviewed our recent experience treating AUC in hospitalized adults with decreased renal function (CrCl < 60 ml/min) with nitrofurantoin...
February 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28137940/antimicrobial-resistance-in-uropathogens-and-appropriateness-of-empirical-treatment-a-population-based-surveillance-study-in-indonesia
#19
Adhi Kristianto Sugianli, Franciscus Ginting, R Lia Kusumawati, Emmy Hermiyati Pranggono, Ayodhia Pitaloka Pasaribu, Firza Gronthoud, Suzanne Geerlings, Ida Parwati, Menno D De Jong, Frank Van Leth, Constance Schultsz
OBJECTIVES: Urinary tract infections (UTIs) are a common reason for empirical treatment with broad-spectrum antibiotics worldwide. However, population-based antimicrobial resistance (AMR) prevalence data to inform empirical treatment choice are lacking in many regions, because of limited surveillance capacity. We aimed to assess the prevalence of AMR to commonly used antimicrobial drugs in Escherichia coli and Klebsiella pneumoniae isolated from patients with community- or healthcare-associated UTIs on two islands of Indonesia...
January 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28137938/repurposing-an-old-drug-aztreonam-as-a-new-treatment-strategy-for-gonorrhoea
#20
Benjamin Davido, Aurelien Dinh, Olivia Senard, Ruxandra Calin, Sabrina Makhloufi, Jerome Salomon
OBJECTIVES: To determine whether aztreonam is still an effective drug for the treatment of gonorrhoea. METHODS: Observational study of patients with gonorrhoea diagnosed by urine multiplex PCR, with a past medical history of allergy to β-lactams or relapse after treatment with a third-generation cephalosporin. Patients received a single 1 g dose of aztreonam in accordance with the manufacturer's instructions. RESULTS: Five patients (four males, one female) were enrolled, comprising two who were allergic to β-lactams and three previously treated with cephalosporins who relapsed...
January 30, 2017: Journal of Antimicrobial Chemotherapy
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