Shaoshi Zhang, Bart Larsen, Valerie Jill Sydnor, Tianchu Zeng, Lijun An, Xiaoxuan Yan, Ru Kong, Xiaolu Kong, Ruben C Gur, Raquel E Gur, Tyler M Moore, Daniel H Wolf, Avram J Holmes, Yapei Xie, Juan Helen Zhou, Marielle V Fortier, Ai Peng Tan, Peter Gluckman, Yap Seng Chong, Michael Meaney, Gustavo Deco, Theodore D Satterthwaite, B T Thomas Yeo
A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function, but challenging to measure in-vivo in humans. Here we present an approach to non-invasively estimate whole-cortex E/I ratio by fitting a large-scale biophysically plausible model to resting-state functional MRI (fMRI) data. We first confirm our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio is sensitive to the GABA-agonist benzodiazepine alprazolam during fMRI...
March 28, 2024: bioRxiv