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https://www.readbyqxmd.com/read/28727713/local-brain-activity-differences-between-herpes-zoster-and-postherpetic-neuralgia-patients-a-resting-state-functional-mri-study
#1
Song Cao, Ying Li, Wenwen Deng, Bangyong Qin, Yi Zhang, Peng Xie, Jie Yuan, Buwei Yu, Tian Yu
BACKGROUND: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. OBJECTIVES: To identify regional brain activity changes in HZ and PHN brains with resting-state functional magnetic resonance imaging (rs-fMRI) technique, and to observe the differences between HZ and PHN patients...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28725547/spatial-working-memory-in-neurofibromatosis-1-altered-neural-activity-and-functional-connectivity
#2
Amira F A Ibrahim, Caroline A Montojo, Kristen M Haut, Katherine H Karlsgodt, Laura Hansen, Eliza Congdon, Tena Rosser, Robert M Bilder, Alcino J Silva, Carrie E Bearden
BACKGROUND: Neurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1. METHODS: BOLD images were acquired from 23 adults with NF1 (age M = 32...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28719854/clinically-silent-alzheimer-s-and-vascular-pathologies-influence-brain-networks-supporting-executive-function-in-healthy-older-adults
#3
Brian T Gold, Christopher A Brown, Jonathan G Hakun, Leslie M Shaw, John Q Trojanowski, Charles D Smith
Aging is associated with declines in executive function. We examined how executive functional brain systems are influenced by clinically silent Alzheimer's disease (AD) pathology and cerebral white-matter hyperintensities (WMHs). Twenty-nine younger adults and 34 cognitively normal older adults completed a working memory paradigm while functional magnetic resonance imaging was performed. Older adults further underwent lumbar cerebrospinal fluid draw for the assessment of AD pathology and FLAIR imaging for the assessment of WMHs...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28719572/neuroimaging-correlates-of-post-stroke-aphasia-rehabilitation-in-a-pilot-randomized-trial-of-constraint-induced-aphasia-therapy
#4
Rodolphe Nenert, Jane B Allendorfer, Amber M Martin, Christi Banks, Angel Ball, Jennifer Vannest, Aimee R Dietz, Jerzy P Szaflarski
BACKGROUND Recovery from post-stroke aphasia is a long and complex process with an uncertain outcome. Various interventions have been proposed to augment the recovery, including constraint-induced aphasia therapy (CIAT). CIAT has been applied to patients suffering from post-stroke aphasia in several unblinded studies to show mild-to-moderate linguistic gains. The aim of the present study was to evaluate the neuroimaging correlates of CIAT in patients with chronic aphasia related to left middle cerebral artery stroke...
July 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28708977/relative-cortico-subcortical-shift-in-brain-activity-but-preserved-training-induced-neural-modulation-in-older-adults-during-bimanual-motor-learning
#5
Thiago Santos Monteiro, Iseult A M Beets, Matthieu P Boisgontier, Jolien Gooijers, Lisa Pauwels, Sima Chalavi, Brad King, Geneviève Albouy, Stephan P Swinnen
To study age-related differences in neural activation during motor learning, functional magnetic resonance imaging scans were acquired from 25 young (mean 21.5-year old) and 18 older adults (mean 68.6-year old) while performing a bimanual coordination task before (pretest) and after (posttest) a 2-week training intervention on the task. We studied whether task-related brain activity and training-induced brain activation changes differed between age groups, particularly with respect to the hyperactivation typically observed in older adults...
June 19, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28707959/interactions-of-the-salience-network-and-its-subsystems-with-the-default-mode-and-the-central-executive-networks-in-normal-aging-and-mild-cognitive-impairment
#6
Ganesh Chand, Junjie Wu, Ihab Hajjar, Deqiang Qiu
Previous functional MRI (fMRI) investigations suggest that the intrinsically organized large-scale networks and the interaction between them might be crucial for cognitive activities. A triple network model, which consists of the default-mode network, salience network, and central-executive network, has been recently employed to understand the connectivity patterns of the cognitively normal brains versus the brains with disorders. This model suggests that the salience network dynamically controls the default-mode and central-executive networks in healthy young individuals...
July 14, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28706990/distinct-distributed-patterns-of-neural-activity-are-associated-with-two-languages-in-the-bilingual-brain
#7
Min Xu, Daniel Baldauf, Chun Qi Chang, Robert Desimone, Li Hai Tan
A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some studies because of different proficiency levels and/or age of acquisition of the two languages. However, one important possibility is that the two languages may involve interleaved but functionally independent neural populations within a given cortical region, and thus, distinct patterns of neural computations may be pivotal for the processing of the two languages...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28706728/effects-of-ageing-and-alzheimer-disease-on-haemodynamic-response-function-a-challenge-for-event-related-fmri
#8
Davud Asemani, Hassan Morsheddost, Mahsa Alizadeh Shalchy
Functional magnetic resonance imaging (fMRI) can generate brain images that show neuronal activity due to sensory, cognitive or motor tasks. Haemodynamic response function (HRF) may be considered as a biomarker to discriminate the Alzheimer disease (AD) from healthy ageing. As blood-oxygenation-level-dependent fMRI signal is much weak and noisy, particularly for the elderly subjects, a robust method is necessary for HRF estimation to efficiently differentiate the AD. After applying minimum description length wavelet as an extra denoising step, deconvolution algorithm is here employed for HRF estimation, substituting the averaging method used in the previous works...
June 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28704424/examining-distinct-working-memory-processes-in-children-and-adolescents-using-fmri-results-and-validation-of-a-modified-brown-peterson-paradigm
#9
Vanessa Siffredi, Pierre Barrouillet, Megan Spencer-Smith, Maarten Vaessen, Vicki Anderson, Patrik Vuilleumier
Verbal working memory (WM) comprises different processes (encoding, maintenance, retrieval) that are often compromised in brain diseases, but their neural correlates have not yet been examined in childhood and adolescence. To probe WM processes and associated neural correlates in developmental samples, and obtain comparable effects across different ages and populations, we designed an adapted Brown-Peterson task (verbal encoding and retrieval combined with verbal and visual concurrent tasks during maintenance) to implement during functional magnetic resonance imaging (fMRI)...
2017: PloS One
https://www.readbyqxmd.com/read/28698644/cognitive-performance-in-healthy-older-adults-relates-to-spontaneous-switching-between-states-of-functional-connectivity-during-rest
#10
Joana Cabral, Diego Vidaurre, Paulo Marques, Ricardo Magalhães, Pedro Silva Moreira, José Miguel Soares, Gustavo Deco, Nuno Sousa, Morten L Kringelbach
Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695791/lutein-and-zeaxanthin-influence-brain-function-in-older-adults-a-randomized-controlled-trial
#11
Cutter A Lindbergh, Lisa M Renzi-Hammond, Billy R Hammond, Douglas P Terry, Catherine M Mewborn, Antonio N Puente, L Stephen Miller
OBJECTIVES: The present study constitutes the first randomized controlled trial to investigate the relation of lutein (L) and zeaxanthin (Z) to brain function using functional magnetic resonance imaging (fMRI). It was hypothesized that L and Z supplementation in older adults would enhance neural efficiency (i.e., reduce activation) and cognitive performance on a verbal learning task relative to placebo. METHODS: A total of 44 community-dwelling older adults (mean age=72 years) were randomly assigned to receive either placebo or L+Z supplementation (12 mg/daily) for 1 year...
July 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28689258/differences-in-dynamic-and-static-functional-connectivity-between-young-and-elderly-healthy-adults
#12
Ji Eun Park, Seung Chai Jung, Kyeoung Hwa Ryu, Joo Young Oh, Ho Sung Kim, Choong-Gon Choi, Sang Joon Kim, Woo Hyun Shim
PURPOSE: Brain connectivity is highly dynamic, but functional connectivity (FC) studies using resting-state functional magnetic resonance imaging (rs-fMRI) assume it to be static. This study assessed differences in dynamic FC between young healthy adults (YH) and elderly healthy adults (EH) compared to static FC. METHODS: Using rs-fMRI data from 12 YH and 31 EH, FC was assessed in six functional regions (subcortical, auditory [AUD], sensorimotor [SM], visuospatial [VS], cognitive control [CC], and default mode network [DMN])...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28689053/schema-benefit-vs-proactive-interference-contradicting-behavioral-outcomes-and-coexisting-neural-patterns
#13
Noga Oren, Irit Shapira-Lichter, Yulia Lerner, Ricardo Tarrasch, Talma Hendler, Nir Giladi, Elissa L Ash
Prior knowledge can either assist or hinder the ability to learn new information. These contradicting behavioral outcomes, referred to as schema benefit and proactive interference respectively, have been studied separately. Here we examined whether the known neural correlates of each process coexist, and how they are influenced by attentional loading and aging. To this end we used an fMRI task that affected both processes simultaneously by presenting pairs of related short movies in succession. The first movie of each pair provided context for the second movie, which could evoke schema benefit and/or proactive interference...
July 5, 2017: NeuroImage
https://www.readbyqxmd.com/read/28687473/brain-functional-alterations-in-type-2-diabetes-a-systematic-review-of-fmri-studies
#14
REVIEW
Helen Macpherson, Melissa Formica, Elizabeth Harris, Robin M Daly
Type 2 Diabetes (T2DM) is emerging as a major global health issue. T2DM can adversely affect cognition and increase dementia risk. This systematic review aimed to examine the functional brain changes that may underlie cognitive dysfunction in adults with T2DM. Studies were restricted to those which used functional magnetic resonance imaging (fMRI). Nineteen independent studies were identified, mostly comprised of middle aged or older adults. Resting-state studies demonstrated that compared to controls, connectivity of the Default Mode Network (DMN) was reduced and the majority of task-based studies identified reduced activation in T2DM patients in regions relevant to task performance...
July 4, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28682248/fused-estimation-of-sparse-connectivity-patterns-from-rest-fmri-application-to-comparison-of-children-and-adult-brains
#15
Pascal Zille, Vince D Calhoun, Julia M Stephen, Tony W Wilson, Yu-Ping Wang
In this work, we consider the problem of estimating multiple sparse, co-activated brain regions from functional magnetic resonance imaging (fMRI) observations belonging to different classes. More precisely, we propose a method to analyze similarities and differences in functional connectivity between children and young adults. Often, analysis is conducted on each class separately, and differences across classes are identified with an additional postprocessing step using adequate statistical tools. Here, we propose to rely on a generalized fused Lasso penalty, which allows us to make use of the entire dataset in order to estimate connectivity patterns that are either shared across classes, or specific to a given group...
June 29, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28679330/altered-brain-network-centrality-in-patients-with-adult-comitant-exotropia-strabismus-a-resting-state-fmri-study
#16
Gang Tan, Zeng-Renqing Dan, Ying Zhang, Xin Huang, Yu-Lin Zhong, Lin-Hong Ye, Rong Rong, Lei Ye, Qiong Zhou, Yi Shao
Objective To investigate the underlying functional network brain-activity changes in patients with adult comitant exotropia strabismus (CES) and the relationship with clinical features using the voxel-wise degree centrality (DC) method. Methods A total of 30 patients with CES (17 men, 13 women), and 30 healthy controls (HCs; 17 men, 13 women) matched in age, sex, and education level participated in the study. DC was used to evaluate spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was conducted to distinguish CESs from HCs...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28678703/enforcing-co-expression-within-a-brain-imaging-genomics-regression-framework
#17
Pascal Zille, Vince D Calhoun, Yu-Ping Wang
Among the challenges arising in brain imaging genetic studies, estimating the potential links between neurological and genetic variability within a population is key. In this work, we propose a multivariate, multimodal formulation for variable selection that leverages co-expression patterns across various data modalities. Our approach is based on an intuitive combination of two widely used statistical models: sparse regression and canonical correlation analysis (CCA). While the former seeks multivariate linear relationships between a given phenotype and associated observations, the latter searches to extract co-expression patterns between sets of variables belonging to different modalities...
June 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28674515/investigating-the-blood-oxygenation-level-dependent-functional-mri-response-to-a-verbal-fluency-task-in-early-stroke-before-and-after-hemodynamic-scaling
#18
Veena A Nair, Ryan V Raut, Vivek Prabhakaran
BACKGROUND AND OBJECTIVE: Blood oxygenation level-dependent (BOLD) functional MRI (fMRI) has been extensively used as a marker of brain dysfunction and subsequent recovery following stroke. However, growing evidence suggests that straightforward interpretation of BOLD fMRI changes with aging and disease is challenging. In this study, we investigated the effect of calibrating task fMRI data by applying a hemodynamic calibration method using the resting-state fluctuation amplitude (RSFA)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28673832/neural-functional-correlates-of-empathic-face-processing
#19
Antonio Del Casale, Georgios D Kotzalidis, Chiara Rapinesi, Delfina Janiri, Massimiliano Aragona, Antonella Puzella, Edoardo Spinazzola, Matteo Maggiora, Giulia Giuseppin, Stefano Maria Tamorri, Alessandro Emiliano Vento, Stefano Ferracuti, Gabriele Sani, Maurizio Pompili, Paolo Girardi
OBJECTIVES: Empathy is a human trait related to the ability to share someone else's feelings, and emotional face processing is one of its measures. Functional Magnetic Resonance Imaging (fMRI) studies showed significant neural correlates of empathic face processing. We aimed to identify those brain areas most consistently involved in empathy for emotional faces. METHODS: We carried ALE meta-analysis of whole-brain data from fMRI studies during empathic face-processing tasks...
July 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28671558/brain-functional-connectivity-is-modified-by-a-hypocaloric-mediterranean-diet-and-physical-activity-in-obese-women
#20
Natalia García-Casares, María R Bernal-López, Nuria Roé-Vellvé, Mario Gutiérrez-Bedmar, Jose C Fernández-García, Juan A García-Arnés, José R Ramos-Rodriguez, Francisco Alfaro, Sonia Santamaria-Fernández, Trevor Steward, Susana Jiménez-Murcia, Isabel Garcia-Garcia, Pedro Valdivielso, Fernando Fernández-Aranda, Francisco J Tinahones, Ricardo Gómez-Huelgas
Functional magnetic resonance imaging (fMRI) in the resting state has shown altered brain connectivity networks in obese individuals. However, the impact of a Mediterranean diet on cerebral connectivity in obese patients when losing weight has not been previously explored. The aim of this study was to examine the connectivity between brain structures before and six months after following a hypocaloric Mediterranean diet and physical activity program in a group of sixteen obese women aged 46.31 ± 4.07 years...
July 1, 2017: Nutrients
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