keyword
MENU ▼
Read by QxMD icon Read
search

aging fmri brain

keyword
https://www.readbyqxmd.com/read/28424611/modafinil-induced-changes-in-functional-connectivity-in-the-cortex-and-cerebellum-of-healthy-elderly-subjects
#1
Miriam Punzi, Tommaso Gili, Laura Petrosini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28422373/longitudinal-recovery-of-local-neuronal-activity-and-consciousness-level-in-acquired-brain-injury
#2
Qihong Zou, Xuehai Wu, Jin Hu, Weijun Tang, Ying Mao, Jianhong Zhu, Lu Lu, Yao Zhang, Jia-Hong Gao
Decreased brain activity in the default mode network, particularly in the precuneus (PCU), has been consistently shown in acquired brain injury (ABI) patients. However, it is unclear whether resting-state brain activity recovers longitudinally in ABI patients and whether functional activity restoration is associated with improvements in consciousness level. Here, resting-state fMRI data were acquired from 23 ABI patients and 30 age- and gender-matched controls with two longitudinal observations for each participant...
April 19, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28420985/mapping-dorsal-and-ventral-caudate-in-older-adults-method-and-validation
#3
Haiqing Huang, Peter T Nguyen, Nadine A Schwab, Jared J Tanner, Catherine C Price, Mingzhou Ding
The caudate nucleus plays important roles in cognition and affect. Depending on associated connectivity and function, the caudate can be further divided into dorsal and ventral aspects. Dorsal caudate, highly connected to dorsolateral prefrontal cortex (DLPFC), is implicated in executive function and working memory; ventral caudate, more interconnected with the limbic system, is implicated in affective functions such as pain processing. Clinically, certain brain disorders are known to differentially impact dorsal and ventral caudate...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28420981/age-related-difference-in-functional-brain-connectivity-of-mastication
#4
Chia-Shu Lin, Ching-Yi Wu, Shih-Yun Wu, Hsiao-Han Lin, Dong-Hui Cheng, Wen-Liang Lo
The age-related decline in motor function is associated with changes in intrinsic brain signatures. Here, we investigated the functional connectivity (FC) associated with masticatory performance, a clinical index evaluating general masticatory function. Twenty-six older adults (OA) and 26 younger (YA) healthy adults were recruited and assessed using the masticatory performance index (MPI) and resting-state functional magnetic resonance imaging (rs-fMRI). We analyzed the rs-fMRI FC network related to mastication, which was constructed based on 12 bilateral mastication-related brain regions according to the literature...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28417233/a-posterior-to-anterior-shift-of-brain-functional-dynamics-in-aging
#5
Han Zhang, Annie Lee, Anqi Qiu
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI...
April 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28415142/neural-correlates-of-cognitive-processing-in-monolinguals-and-bilinguals
#6
REVIEW
John G Grundy, John A E Anderson, Ellen Bialystok
Here, we review the neural correlates of cognitive control associated with bilingualism. We demonstrate that lifelong practice managing two languages orchestrates global changes to both the structure and function of the brain. Compared with monolinguals, bilinguals generally show greater gray matter volume, especially in perceptual/motor regions, greater white matter integrity, and greater functional connectivity between gray matter regions. These changes complement electroencephalography findings showing that bilinguals devote neural resources earlier than monolinguals...
April 17, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28414133/complexity-of-weighted-graph-a-new-technique-to-investigate-structural-complexity-of-brain-activities-with-applications-to-aging-and-autism
#7
Mehran Ahmadlou, Hojjat Adeli
In recent years complexity of the brain structure in healthy and disordered subjects has been studied increasingly. But to the best of the authors' knowledge, researchers so far have investigated the structural complexity only in the context of two restricted networks known as Small-World and Scale-free networks; whereas other aspects of the structural complexity of brain activities may be affected by aging and neurodegenerative disorders such as the Alzheimer's disease and autism spectrum disorder. In this study, two general complexity metrics of graphs, Graph Index Complexity and Offdiagonal Complexity are proposed as general measures of complexity, not restricted to SWN only...
April 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28413778/family-history-and-apoe4-risk-for-alzheimer-s-disease-impact-the-neural-correlates-of-episodic-memory-by-early-midlife
#8
M N Rajah, L M K Wallace, E Ankudowich, E H Yu, A Swierkot, R Patel, M M Chakravarty, D Naumova, J Pruessner, R Joober, S Gauthier, S Pasvanis
Episodic memory impairment is a consistent, pronounced deficit in pre-clinical stages of late-onset Alzheimer's disease (AD). Individuals with risk factors for AD exhibit altered brain function several decades prior to the onset of AD-related symptoms. In the current event-related fMRI study of spatial context memory we tested the hypothesis that middle-aged adults (MA; 40-58 yrs) with a family history of late onset AD (MA+ FH), or a combined + FH and apolipoprotein E ε4 allele risk factors for AD (MA+ FH + APOE4), will exhibit differences in encoding and retrieval-related brain activity, compared to - FH - APOE4 MA controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28413708/neural-evidence-for-phonologically-based-language-production-deficits-in-older-adults-an-fmri-investigation-of-age-related-differences-in-picture-word-interference
#9
Avery A Rizio, Karlee J Moyer, Michele T Diaz
INTRODUCTION: Older adults often show declines in phonological aspects of language production, particularly for low-frequency words, but maintain strong semantic systems. However, there are different theories about the mechanism that may underlie such age-related differences in language (e.g., age-related declines in transmission of activation or inhibition). METHODS: This study used fMRI to investigate whether age-related differences in language production are associated with transmission deficits or inhibition deficits...
April 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28411527/development-of-sensitivity-versus-specificity-for-print-in-the-visual-word-form-area
#10
Tracy M Centanni, Livia W King, Marianna D Eddy, Susan Whitfield-Gabrieli, John D E Gabrieli
An area near the left lateral occipito-temporal sulcus that responds preferentially to print has been designated as the visual word form area (VWFA). Research suggests that specialization in this brain region increases as reading expertise is achieved. Here we aimed to characterize that development in terms of sensitivity (response to printed words relative to non-linguistic faces) versus specificity (response to printed words versus line drawings of nameable objects) in typically reading children ages 7-14 versus young adults as measured by functional magnetic resonance imaging (fMRI)...
April 12, 2017: Brain and Language
https://www.readbyqxmd.com/read/28406312/repeatability-of-graph-theoretical-metrics-derived-from-resting-state-functional-networks-in-pediatric-epilepsy-patients
#11
Michael J Paldino, Zili D Chu, Mary L Chapieski, Farahnaz Golriz, Wei Zhang
OBJECTIVES: To measure the repeatability of metrics that quantify brain network architecture derived from resting-state fMRI (rs-fMRI) in a cohort of pediatric epilepsy patients. METHODS: We identified patients with: 1. epilepsy; 2. brain MRI at 3 Tesla; 3. two identical rs-fMRI acquisitions performed on the same day. Undirected, weighted networks were constructed based on the resting state time series using a range of processing parameters including parcellation size and graph threshold...
April 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28402574/hard-to-look-on-the-bright-side-neural-correlates-of-impaired-emotion-regulation-in-depressed-youth
#12
Katerina Stephanou, Christopher G Davey, Rebecca Kerestes, Sarah Whittle, Ben J Harrison
The cognitive regulation of emotion is impaired in major depressive disorder and has been linked to an imbalance of prefrontal-subcortical brain activity. Despite suggestions that this relationship represents a neurodevelopmental marker of depression, few studies have examined the neural correlates of emotion regulation in depressed youth. We combined a 'cognitive reappraisal' paradigm with functional magnetic resonance imaging to study the neural correlates of emotional regulation in a large sample of non-medicated depressed adolescents and young adults (n = 53), and healthy controls (n = 64)...
April 11, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28401835/brain-activity-and-infant-attachment-history-in-young-men-during-loss-and-reward-processing
#13
Karina Quevedo, Theodore E A Waters, Hannah Scott, Glenn I Roisman, Daniel S Shaw, Erika E Forbes
There is now ample evidence that the quality of early attachment experiences shapes expectations for supportive and responsive care and ultimately serves to scaffold adaptation to the salient tasks of development. Nonetheless, few studies have identified neural mechanisms that might give rise to these associations. Using a moderately large sample of low-income male participants recruited during infancy (N = 171), we studied the predictive significance of attachment insecurity and disorganization at age 18 months (as measured in the Strange Situation Procedure) for patterns of neural activation to reward and loss at age 20 years (assessed during a reward-based task as part of a functional magnetic resonance imaging scan)...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401670/adolescents-behavioral-and-neural-responses-to-e-cigarette-advertising
#14
Yvonnes Chen, Carina H Fowler, Vlad B Papa, Rebecca J Lepping, Morgan G Brucks, Andrew T Fox, Laura E Martin
Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n = 41) and non-smokers (n = 41) answered questions about e-cigarette and neutral advertising images. The 40 e-cigarette advertising images that most increased desire to use the product were matched to 40 neutral advertising images with similar content...
April 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28397386/brain-atrophy-can-introduce-age-related-differences-in-bold-response
#15
Xueqing Liu, Raphael T Gerraty, Jack Grinband, David Parker, Qolamreza R Razligh
Use of functional magnetic resonance imaging (fMRI) in studies of aging is often hampered by uncertainty about age-related differences in the amplitude and timing of the blood oxygenation level dependent (BOLD) response (i.e., hemodynamic impulse response function (HRF)). Such uncertainty introduces a significant challenge in the interpretation of the fMRI results. Even though this issue has been extensively investigated in the field of neuroimaging, there is currently no consensus about the existence and potential sources of age-related hemodynamic alterations...
April 11, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28392763/activation-in-context-differential-conclusions-drawn-from-cross-sectional-and-longitudinal-analyses-of-adolescents-cognitive-control-related-neural-activity
#16
Ethan M McCormick, Yang Qu, Eva H Telzer
Although immature cognitive control, subserved by late-developing prefrontal regions, has been proposed to underlie increased risk taking during adolescence, it remains unclear what patterns of PFC activation represent mature brain states: more or less activation? One challenge to drawing cogent conclusions from extant work stems from its reliance on single-time point neuroimaging and cross-sectional comparisons, which are ill-suited for assessing the complex changes that characterize adolescence. This necessitates longitudinal fMRI work to track within-subject changes in PFC function and links to risk-taking behavior, which can serve as an external marker for maturation of neural systems involved in cognitive control...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28390824/resting-state-networks-associated-with-cognitive-processing-show-more-age-related-decline-than-those-associated-with-emotional-processing
#17
Kaoru Nashiro, Michiko Sakaki, Meredith N Braskie, Mara Mather
Correlations in activity across disparate brain regions during rest reveal functional networks in the brain. Although previous studies largely agree that there is an age-related decline in the "default mode network," how age affects other resting-state networks, such as emotion-related networks, is still controversial. Here we used a dual-regression approach to investigate age-related alterations in resting-state networks. The results revealed age-related disruptions in functional connectivity in all 5 identified cognitive networks, namely the default mode network, cognitive-auditory, cognitive-speech (or speech-related somatosensory), and right and left frontoparietal networks, whereas such age effects were not observed in the 3 identified emotion networks...
March 11, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28374936/effect-of-smoking-on-resting-state-functional-connectivity-in-smokers-an-fmri-study
#18
Shuang Zhou, Dan Xiao, Peng Peng, Shuang-Kun Wang, Zhao Liu, Hai-Yan Qin, Sheng-Shu Li, Chen Wang
BACKGROUND AND OBJECTIVE: Smoking is a leading cause of death in the world. Aberrant brain function has been repeatedly linked to tobacco smoking. However, little is known about insula-based resting-state functional connectivity (rsFC) in non-deprived tobacco-dependent smokers. This study characterized the correlation between insula-based rsFC and tobacco dependence severity in non-deprived smokers. METHODS: A total of 37 male smokers and 37 age-matched male non-smokers completed resting-state functional MRI (fMRI) scans...
April 4, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28374009/longitudinal-changes-in-component-processes-of-working-memory
#19
Anna Rieckmann, Sara Pudas, Lars Nyberg
Working memory (WM) entails maintenance and manipulation of information in the absence of sensory input. This study investigated the trajectories and neural basis of these component processes of WM functions in aging. Longitudinal human functional magnetic resonance imaging (fMRI) data are presented from 136 older individuals (55-80 years) who were scanned at baseline and again 4 years later. We obtained evidence that age-related changes in parietal and frontal components of the WM core network are dissociable in terms of their role in maintenance of perceptual representations and further manipulation of this information, respectively...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28370780/higher-serum-cholesterol-is-associated-with-intensified-age-related-neural-network-decoupling-and-cognitive-decline-in-early-to-mid-life
#20
Jeffrey M Spielberg, Naomi Sadeh, Elizabeth C Leritz, Regina E McGlinchey, William P Milberg, Jasmeet P Hayes, David H Salat
Mounting evidence indicates that serum cholesterol and other risk factors for cardiovascular disease intensify normative trajectories of age-related cognitive decline. However, the neural mechanisms by which this occurs remain largely unknown. To understand the impact of cholesterol on brain networks, we applied graph theory to resting-state fMRI in a large sample of early- to mid-life Veterans (N = 206, Meanage  = 32). A network emerged (centered on the banks of the superior temporal sulcus) that evidenced age-related decoupling (i...
March 31, 2017: Human Brain Mapping
keyword
keyword
50480
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"