keyword
MENU ▼
Read by QxMD icon Read
search

taurine and stroke

keyword
https://www.readbyqxmd.com/read/26945820/neuroprotection-of-taurine-against-reactive-oxygen-species-is-associated-with-inhibiting-nadph-oxidases
#1
Zhou Han, Li-Yan Gao, Yu-Hui Lin, Lei Chang, Hai-Yin Wu, Chun-Xia Luo, Dong-Ya Zhu
It is well established that taurine shows potent protection against glutamate-induced injury to neurons in stroke. The neuroprotection may result from multiple mechanisms. Increasing evidences suggest that NADPH oxidases (Nox), the primary source of superoxide induced by N-methyl-d-aspartate (NMDA) receptor activation, are involved in the process of oxidative stress. We found that 100μM NMDA induced oxidative stress by increasing the reactive oxygen species level, which contributed to the cell death, in vitro...
April 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26866594/serum-taurine-and-stroke-risk-in-women-a-prospective-nested-case-control-study
#2
Fen Wu, Karen L Koenig, Anne Zeleniuch-Jacquotte, Saran Jonas, Yelena Afanasyeva, Oktawia P Wójcik, Max Costa, Yu Chen
BACKGROUND: Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. METHODS: We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985...
2016: PloS One
https://www.readbyqxmd.com/read/26644087/taurine-depresses-cardiac-contractility-and-enhances-systemic-heart-glucose-utilization-in-the-cuttlefish-sepia-officinalis
#3
Tyson J MacCormack, N I Callaghan, A V Sykes, W R Driedzic
Taurine is the most abundant amino acid in the blood of the cuttlefish, Sepia officinalis, where levels can exceed 200 mmol L(-1). In mammals, intracellular taurine modulates cardiac Ca(2+) handling and carbohydrate metabolism at much lower concentrations but it is not clear if it exerts similar actions in cephalopods. Blood Ca(2+) levels are high in cephalopods and we hypothesized that taurine would depress cardiac Ca(2+) flux and modulate contractility in systemic and branchial hearts of cuttlefish. Heart performance was assessed with an in situ perfused systemic heart preparation and contractility was evaluated using isometrically contracting systemic and branchial heart muscle rings...
February 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26415593/taurine-protected-against-the-impairments-of-neural-stem-cell-differentiated-neurons-induced-by-oxygen-glucose-deprivation
#4
Bo Xiao, Huazhen Liu, Zeyun Gu, Sining Liu, Cheng Ji
Cell transplantation of neural stem cells (NSCs) is a promising approach for neurological recovery both structurally and functionally. However, one big obstacle is to promote differentiation of NSCs into neurons and the followed maturation. In the present study, we aimed to investigate the protective effect of taurine on the differentiation of NSCs and subsequent maturation of their neuronal lineage, when exposed to oxygen-glucose deprivation (OGD). The results suggested that taurine (5-20 mM) promoted the viability and proliferation of NSCs, and it protected against 8 h of OGD induced impairments...
November 2015: Neurochemical Research
https://www.readbyqxmd.com/read/26022360/comparison-between-single-and-combined-post-treatment-with-s-methyl-n-n-diethylthiolcarbamate-sulfoxide-and-taurine-following-transient-focal-cerebral-ischemia-in-rat-brain
#5
COMPARATIVE STUDY
P Gharibani, J Modi, J Menzie, A Alexandrescu, Z Ma, R Tao, H Prentice, J-Y Wu
We have recently reported on the efficacy of an N-methyl-d-aspartate (NMDA) receptor partial antagonist, S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), in improving outcome following stroke, including reduced infarct size and calcium influx, suppressing the endoplasmic reticulum (ER) stress-induced apoptosis as well as improving behavioral outcome. DETC-MeSO was shown to suppress the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway, one of the major ER stress pathways. Several studies including ours have provided evidence that taurine also has neuroprotective effects through reducing apoptosis and inhibiting activating transcription factor 6 (ATF6) and inositol requiring enzyme 1 (IRE-1) pathways...
August 6, 2015: Neuroscience
https://www.readbyqxmd.com/read/25814258/rapamycin-ameliorates-brain-metabolites-alterations-after-transient-focal-ischemia-in-rats
#6
Anjali Chauhan, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupta
Rapamycin has been shown to protect against middle cerebral artery occlusion (MCAo) induced ischemic injury. In this study, the neuroprotective effect of rapamycin on the metabolic changes induced by MCAo was evaluated using nuclear magnetic resonance (NMR) spectroscopy of brain tissues. MCAo in rats was induced by insertion of nylon filament. One hour after ischemia, rapamycin (250 µg/kg, i.p.) in dimethyl sulfoxide was administered. Reperfusion was done 2h after ischemia. Twenty-four hours after ischemia phospholipase A2 (PLA2) levels and metabolic changes were assessed...
June 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25716925/the-blood-pressure-elevating-effect-of-red-bull-energy-drink-is-mimicked-by-caffeine-but-through-different-hemodynamic-pathways
#7
Jennifer L Miles-Chan, Nathalie Charrière, Erik K Grasser, Jean-Pierre Montani, Abdul G Dulloo
The energy drink Red Bull (RB) has recently been shown to elevate resting blood pressure (BP) and double product (reflecting increased myocardial load). However, the extent to which these effects can be explained by the drink's caffeine and sugar content remains to be determined. We compared the cardiovascular impact of RB to those of a comparable amount of caffeine, and its sugar-free version in eight young healthy men. Participants attended four experimental sessions on separate days according to a placebo-controlled randomized crossover study design...
February 1, 2015: Physiological Reports
https://www.readbyqxmd.com/read/25634261/early-metabolic-changes-following-ischemia-onset-in-rats-an-in-vivo-diffusion-weighted-imaging-and-1h-magnetic-resonance-spectroscopy-study-at-7-0-t
#8
Gen Yan, Zhuozhi Dai, Yinghua Xuan, Renhua Wu
Despite improvements in imaging techniques, it remains challenging to quantitatively assess the time of ischemic onset of an acute ischemic stroke. It is crucial to evaluate the early signs of infarction, which are predictive of responses to recombinant tissue plasminogen activator within a treatment window of 4.5 h after stroke induction. The aim of the present study was to assess and quantify the onset time for hyperacute middle cerebral artery occlusion (MCAO) ischemic stroke by measuring the apparent diffusion coefficient (ADC) of diffusion‑weighted imaging (DWI) and 1H‑magnetic resonance spectroscopy (MRS) at 7...
June 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25224033/the-neuroprotective-properties-of-the-superoxide-dismutase-mimetic-tempol-correlate-with-its-ability-to-reduce-pathological-glutamate-release-in-a-rodent-model-of-stroke
#9
Preeti Dohare, María C Hyzinski-García, Aarshi Vipani, Nicole H Bowens, Julia W Nalwalk, Paul J Feustel, Richard W Keller, David Jourd'heuil, Alexander A Mongin
The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies have failed to show benefits in human stroke. Based on our previous in vitro work, we hypothesized that the neuroprotective potency of antioxidants is related to their ability to limit the release of the excitotoxic amino acids glutamate and aspartate. We explored the effects of two antioxidants, tempol and edaravone, on amino acid release in the brain cortex, in a rat model of transient occlusion of the middle cerebral artery (MCAo)...
December 2014: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/25182663/non-invasive-diagnostic-biomarkers-for-estimating-the-onset-time-of-permanent-cerebral-ischemia
#10
Carole Berthet, Lijing Xin, Lara Buscemi, Corinne Benakis, Rolf Gruetter, Lorenz Hirt, Hongxia Lei
The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brains might allow the precise estimation of cerebral ischemia onset time. We modeled ischemic stroke in male ICR-CD1 mice using a permanent middle cerebral artery filament occlusion model with laser Doppler control of the regional cerebral blood flow. Mice were then subjected to repeated MRS measurements of ipsilateral striatum at 14...
November 2014: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/25172945/lrrc8a-protein-is-indispensable-for-swelling-activated-and-atp-induced-release-of-excitatory-amino-acids-in-rat-astrocytes
#11
María C Hyzinski-García, Alena Rudkouskaya, Alexander A Mongin
In mammals, cellular swelling activates release of small organic osmolytes, including the excitatory amino acids (EAA) glutamate and aspartate, via a ubiquitously expressed volume-regulated chloride/anion channel (VRAC). Pharmacological evidence suggests that VRAC plays plural physiological and pathological roles, including excitotoxic release of glutamate in stroke. However, the molecular identity of this pathway was unknown. Two recent studies discovered that LRRC8 gene family members encode heteromeric VRAC composed of LRRC8A plus LRRC8B-E, which mediate swelling-activated Cl(-) currents and taurine release in human non-neural cells (Z...
November 15, 2014: Journal of Physiology
https://www.readbyqxmd.com/read/24961429/neuroprotective-mechanisms-of-taurine-against-ischemic-stroke
#12
Janet Menzie, Howard Prentice, Jang-Yen Wu
Ischemic stroke exhibits a multiplicity of pathophysiological mechanisms. To address the diverse pathophysiological mechanisms observed in ischemic stroke investigators seek to find therapeutic strategies that are multifaceted in their action by either investigating multipotential compounds or by using a combination of compounds. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions. It exhibits antioxidative properties, stabilizes membrane, functions as an osmoregulator, modulates ionic movements, reduces the level of pro-inflammators, regulates intracellular calcium concentration; all of which contributes to its neuroprotective effect...
2013: Brain Sciences
https://www.readbyqxmd.com/read/24891994/the-unexpected-uses-of-urso-and-tauroursodeoxycholic-acid-in-the-treatment-of-non-liver-diseases
#13
REVIEW
Sheila Vang, Katie Longley, Clifford J Steer, Walter C Low
Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA), a US Food and Drug Administration-approved hydrophilic bile acid for the treatment of certain cholestatic liver diseases. There is a growing body of research on the mechanism(s) of TUDCA and its potential therapeutic effect on a wide variety of non-liver diseases. Both UDCA and TUDCA are potent inhibitors of apoptosis, in part by interfering with the upstream mitochondrial pathway of cell death, inhibiting oxygen-radical production, reducing endoplasmic reticulum (ER) stress, and stabilizing the unfolded protein response (UPR)...
May 2014: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/24844176/nutritional-treatment-for-acute-and-chronic-traumatic-brain-injury-patients
#14
REVIEW
L Curtis, P Epstein
Proper nutrition is critical for recovery from traumatic brain injury (TBI). Prompt enteral feeding of moderate to severe TBI patients has been associated with significantly lower mortality and rates of infection. Probiotic supplementation has been associated with significantly lower rates of infection in TBI and other trauma patients. Human studies have suggested that supplementation with omega 3 fats, vitamin D, N-Acetylcysteine, branched chain amino acids, and zinc may be helpful for recovery from TBI. Animal TBI models have suggested that alpha-lipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients (such as resveratrol) are also helpful...
September 2014: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/24323587/a-combined-treatment-with-taurine-and-intra-arterial-thrombolysis-in-an-embolic-model-of-stroke-in-rats-increased-neuroprotective-efficacy-and-extended-therapeutic-time-window
#15
Weihua Guan, Yumei Zhao, Chao Xu
Combination treatment may target different pathophysiological events following cerebral ischemia thus enhancing the efficacy of treatment in thromboembolic stroke. Taurine confers a neuroprotective effect in the mechanical stroke model. This effect has not been assessed in an embolic stroke model. Here, we sought to evaluate the neuroprotective effect of taurine alone and in combination with thrombolytic therapy to investigate whether combined administration would extend the therapeutic time window without increasing the hemorrhagic transformation in a rat embolic stroke model...
March 2011: Translational Stroke Research
https://www.readbyqxmd.com/read/23544269/simple-and-rapid-quantitation-of-21-bile-acids-in-rat-serum-and-liver-by-uplc-ms-ms-effect-of-high-fat-diet-on-glycine-conjugates-of-rat-bile-acids
#16
Yudai Suzuki, Rina Kaneko, Mina Nomura, Hisao Naito, Kazuya Kitamori, Tamie Nakajima, Tadashi Ogawa, Hideki Hattori, Hiroshi Seno, Akira Ishii
In this report, we present a simple and rapid method for analysis of 21 kinds of bile acids and the conjugates in rat serum and liver samples by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) in the negative ionization mode, using cholic-2, 2, 4, 4-d4 acid as internal standard. After liquid-liguid extraction from serum and liver samples, specimens were analyzed by UPLC equipped with an Acquity TQD tandem quadrupole mass spectrometer. All of the 21 bile acids were sufficiently separated within 5 min...
February 2013: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/23392933/taurine-exerts-robust-protection-against-hypoxia-and-oxygen-glucose-deprivation-in-human-neuroblastoma-cell-culture
#17
Po-Chih Chen, Chunliu Pan, Payam M Gharibani, Howard Prentice, Jang-Yen Wu
Stroke is one of the leading causes of mortality and disability worldwide. There is no effective treatment for stroke despite extensive research. Taurine is a free amino acid which is present at high concentrations in a range of organs including the brain, heart, and retina in mammalian systems. It had been shown that taurine can significantly increase cell survival under stroke conditions using both in vivo and in vitro models. Recently, we have found that several agents including granulocyte colony-stimulating factor (G-CSF), a stem cell enhancer and facilitator;S-methyl-N-diethylthiolcarbamate sulfoxide (DETC-MeSO), an NMDA receptor partial antagonist; sulindac, a potent antioxidant; and taurine, a neuroprotectant and calcium regulator, are effective in protecting against stroke-induced neuronal injury when used alone or in combination in both animal and tissue/cell culture models...
2013: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/23392887/the-mechanism-of-taurine-protection-against-endoplasmic-reticulum-stress-in-an-animal-stroke-model-of-cerebral-artery-occlusion-and-stroke-related-conditions-in-primary-neuronal-cell-culture
#18
Payam Mohammad Gharibani, Jigar Modi, Chunliu Pan, Janet Menzie, Zhiyuan Ma, Po-Chih Chen, Rui Tao, Howard Prentice, Jang-Yen Wu
Taurine is an inhibitory neurotransmitter and is one of the most abundant amino acids present in the mammalian nervous system. Taurine has been shown to provide protection against neurological diseases, such as Huntington's disease, Alzheimer's disease, and stroke. Ischemic stroke is one of the leading causes of death and disability in the world. It is generally believed that ischemia-induced brain injury is largely due to excessive release of glutamate resulting in excitotoxicity and cell death. Despite extensive research, there are still no effective interventions for stroke...
2013: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/23392880/taurine-deficiency-and-melas-are-closely-related-syndromes
#19
REVIEW
Stephen W Schaffer, Chian Ju Jong, Danielle Warner, Takashi Ito, Junichi Azuma
MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is a mitochondrial disease caused by one or more mutations of tRNA(Leu(UUR)). These mutations reduce both the aminoacylation of tRNA(Leu(UUR)) and a posttranslational modification in the wobble position of tRNA(Leu(UUR)). Both changes result in reduced transcription of mitochondria-encoded proteins; however, reduced aminoacylation affects the decoding of both UUG and UUA while the wobble defect specifically diminishes UUG decoding...
2013: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/23285272/deletion-of-traak-potassium-channel-affects-brain-metabolism-and-protects-against-ischemia
#20
Christophe Laigle, Sylviane Confort-Gouny, Yann Le Fur, Patrick J Cozzone, Angèle Viola
Cerebral stroke is a worldwide leading cause of disability. The two-pore domain K⁺ channels identified as background channels are involved in many functions in brain under physiological and pathological conditions. We addressed the hypothesis that TRAAK, a mechano-gated and lipid-sensitive two-pore domain K⁺ channel, is involved in the pathophysiology of brain ischemia. We studied the effects of TRAAK deletion on brain morphology and metabolism under physiological conditions, and during temporary focal cerebral ischemia in Traak⁻/⁻ mice using a combination of in vivo magnetic resonance imaging (MRI) techniques and multinuclear magnetic resonance spectroscopy (MRS) methods...
2012: PloS One
keyword
keyword
50475
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"