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https://www.readbyqxmd.com/read/29748917/taurine-protects-from-pentylenetetrazole-induced-behavioral-and-neurochemical-changes-in-zebrafish
#1
Barbara D Fontana, Paola R Ziani, Julia Canzian, Nathana J Mezzomo, Talise E Müller, Matheus M Dos Santos, Vania L Loro, Nilda V Barbosa, Carlos F Mello, Denis B Rosemberg
Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures, which culminate in various neurobehavioral and neurochemical changes. Taurine (TAU) is an amino sulfonic acid which acts an endogenous inhibitory neuromodulator. Moreover, TAU displays intrinsic antioxidant activity, contributing to its beneficial actions in the CNS. Here, we evaluated whether TAU pretreatment protects from pentylenetetrazole (PTZ)-induced behavioral alterations and oxidative stress-related parameters in zebrafish brain tissue...
May 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29747866/understanding-taurine-cns-activity-using-alternative-zebrafish-models
#2
Nathana J Mezzomo, Barbara D Fontana, Allan V Kalueff, Leonardo J G Barcellos, Denis B Rosemberg
Taurine is a highly abundant "amino acid" in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action...
May 7, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29740359/profiling-of-amino-acids-and-their-derivatives-biogenic-amines-before-and-after-antipsychotic-treatment-in-first-episode-psychosis
#3
Liisa Leppik, Kärt Kriisa, Kati Koido, Kadri Koch, Kärolin Kajalaid, Liina Haring, Eero Vasar, Mihkel Zilmer
Schizophrenia (SCH) is a heterogeneous disorder, deriving from a potential multitude of etiopathogenetic factors. During the past few years there has been an increasing interest in the role of circulating amino acids (AAs) and biogenic amines (BAs) in the pathophysiology of SCH. In the present study, we aimed to provide an insight into the potential role of alterations in levels of AAs and BAs as well as examine their more specific metabolic shifts in relation to early stage of SCH. We measured 21 AAs and 17 BAs in serum samples of patients with first-episode psychosis (FEP) before and after 7-month antipsychotic treatment in comparison to control subjects (CSs)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29694913/effects-of-taurine-on-striatal-dopamine-transporter-expression-and-dopamine-uptake-in-shr-rats
#4
Vincent Chin-Hung Chen, Chun-Ching Chiu, Li-Jeng Chen, Tsai-Ching Hsu, Bor-Show Tzang
Dopaminergic deficits in the prefrontal cortex and striatum have been attributed to the pathogenesis of attention-deficit hyperactivity disorder (ADHD). Our recent study revealed that high-dose taurine improves hyperactive behavior and brain-functional signals in SHR rats. This study investigates the effect of taurine on the SHR striatum by detecting the spontaneous alternation, DA transporter (DAT) level, dopamine uptake and brain-derived neurotrophic factor (BDNF) expression. A significant increase in the total arm entries was detected in both WKY and SHR rats fed with low-dose taurine but not in those fed with high-dose taurine...
April 22, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29680253/longitudinal-study-of-irradiation-induced-brain-microstructural-alterations-with-s-index-a-diffusion-mri-biomarker-and-mr-spectroscopy
#5
Elodie Anne Pérès, Olivier Etienne, Antoine Grigis, Fawzi Boumezbeur, François Dominique Boussin, Denis Le Bihan
PURPOSE: Radiation therapy is widely used for the treatment of brain tumors, but it may lead to severe cognitive impairments. Previous studies have shown that ionizing irradiation induces demyelination, blood-brain barrier alterations, and impaired neurogenesis in animal models. Hence, noninvasive and sensitive biomarkers of irradiation injury are needed to investigate these effects in patients and improve radiation therapy protocols. METHODS AND MATERIALS: The heads of 3-month-old male C57BL/6RJ mice (15 control mice and 15 irradiated mice) were exposed to radiation doses of 3 fractions of 5 Gy from a 60 Co source with a medical irradiator...
February 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29668904/a-whole-brain-longitudinal-study-in-the-yac128-mouse-model-of-huntington-s-disease-shows-distinct-trajectories-of-neurochemical-structural-connectivity-and-volumetric-changes
#6
Lorena I Petrella, João M Castelhano, Mario Ribeiro, José V Sereno, Sónia I Gonçalves, Mário N Laço, Michael R Hayden, Ana C Rego, Miguel Castelo-Branco
Huntington's disease (HD) is a neurodegenerative disorder causing cognitive and motor impairments, evolving to death within 15-20 years after symptom onset. We previously established a mouse model with the entire human HD gene containing 128 CAG repeats (YAC128) which accurately recapitulates the natural history of the human disease. Defined time points in this natural history enable the understanding of longitudinal trajectories from the neurochemical and structural points of view using non-invasive high-resolution multimodal imaging...
April 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29656312/evaluation-of-taurine-neuroprotection-in-aged-rats-with-traumatic-brain-injury
#7
Raeesa Gupte, Sarah Christian, Paul Keselman, Joshua Habiger, William M Brooks, Janna L Harris
Despite higher rates of hospitalization and mortality following traumatic brain injury (TBI) in patients over 65 years old, older patients remain underrepresented in drug development studies. Worse outcomes in older individuals compared to younger adults could be attributed to exacerbated injury mechanisms including oxidative stress, inflammation, blood-brain barrier disruption, and bioenergetic dysfunction. Accordingly, pleiotropic treatments are attractive candidates for neuroprotection. Taurine, an endogenous amino acid with antioxidant, anti-inflammatory, anti-apoptotic, osmolytic, and neuromodulator effects, is neuroprotective in adult rats with TBI...
April 14, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29621152/taurine-administration-recovers-motor-and-learning-deficits-in-an-angelman-syndrome-mouse-model
#8
Sara Guzzetti, Luciano Calzari, Lucia Buccarello, Valentina Cesari, Ivan Toschi, Stefania Cattaldo, Alessandro Mauro, Francesca Pregnolato, Silvia Michela Mazzola, Silvia Russo
Angelman syndrome (AS, MIM 105830) is a rare neurodevelopmental disorder affecting 1:10-20,000 children. Patients show moderate to severe intellectual disability, ataxia and absence of speech. Studies on both post-mortem AS human brains and mouse models revealed dysfunctions in the extra synaptic gamma-aminobutyric acid (GABA) receptors implicated in the pathogenesis. Taurine is a free intracellular sulfur-containing amino acid, abundant in brain, considered an inhibiting neurotransmitter with neuroprotective properties...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29578001/long-term-administration-of-greek-royal-jelly-decreases-gaba-concentration-in-the-striatum-and-hypothalamus-of-naturally-aged-wistar-male-rats
#9
Justyna Pyrzanowska, Adriana Wawer, Ilona Joniec-Maciejak, Agnieszka Piechal, Kamilla Blecharz-Klin, Konstantia Graikou, Ioanna Chinou, Ewa Widy-Tyszkiewicz
Royal Jelly (RJ) is a unique substance obtained from bees that has been used widely in European and Asian traditional medicine for its potential to prevent signs of aging through its antioxidative, anti-inflammatory, anti-hyperglycemic and anti-hypercholesterolemic properties. We recently reported an enhancement in spatial memory along with changes in monoaminergic transmission in aged rats after chronic RJ administration. Here, we aim to further explore the action of RJ on central nervous system activity by examining levels of amino acids in selected brain structures of aged male Wistar rats following 2-months of Greek RJ administration...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29571023/pretreatment-with-taurine-prevented-brain-injury-and-exploratory-behaviour-associated-with-administration-of-anticancer-drug-cisplatin-in-rats
#10
Olatunde Owoeye, Isaac A Adedara, Ebenezer O Farombi
The neurotoxicity associated with cisplatin treatment is one of the major side effects compromising the efficacy of the anti-cancer treatment. The present study investigated the possible protective effects of taurine, an intracellular amino acid, on cisplatin-induced brain injury and exploratory behaviour using five groups of ten female rats each. Group I received drinking water only. Group II orally received taurine alone at 200 mg/kg whereas Group III received cisplatin alone intraperitoneally at 10 mg/kg...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29561067/adjunctive-nutrients-in-first-episode-psychosis-a-systematic-review-of-efficacy-tolerability-and-neurobiological-mechanisms
#11
REVIEW
Joseph Firth, Simon Rosenbaum, Philip B Ward, Jackie Curtis, Scott B Teasdale, Alison R Yung, Jerome Sarris
AIM: The effects of nutrient-based treatments, including adjunctive vitamin or antioxidant supplementation, have been explored extensively in long-term schizophrenia. However, no systematic evaluation of trials in "first-episode psychosis" (FEP) has been conducted, despite the potential benefits of using these treatments during the early stages of illness. Therefore, we aimed to review all studies examining efficacy, tolerability and the biological mechanisms of action, of nutrient supplementation in FEP...
March 21, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29538445/acute-effect-of-ethanol-and-taurine-on-frontal-cortex-absolute-beta-power-before-and-after-exercise
#12
Dailson Paulucio, Augusto Terra, Caleb G Santos, Mauricio Cagy, Bruna Velasques, Pedro Ribeiro, Bruno M da Costa, Mariana Gongora, Renato Alvarenga, Luciano Alonso, Fernando A M S Pompeu
Ethanol (ET) is a substance that modulates the Central Nervous System (CNS). Frequently, ET intake occurs combined with energy drinks, which contain taurine (TA), an important amino acid found in the body (i.e brain and muscles). Although TA administration has been used in the improvement of physical performance, the impact of TA, ET and exercise remains unknown. This study aimed to analyze the acute effect of 6g of Taurine (TA), 0.6 mL∙kg-1 of Ethanol (ET), and Taurine combined with Ethanol (TA+ET) ingestion on the electrocortical activity before and after a moderate intensity exercise in 9 subjects, 5 women (counterbalanced experimental design)...
2018: PloS One
https://www.readbyqxmd.com/read/29518649/-1-h-nuclear-magnetic-resonance-metabolomics-revealing-the-intrinsic-relationships-between-neurochemical-alterations-and-neurobehavioral-and-neuropathological-abnormalities-in-rats-exposed-to-tris-2-chloroethyl-phosphate
#13
Weiqun Yang, Fei Zhao, Yanjun Fang, Li Li, Chaonan Li, Na Ta
Tris(2-chloroethyl)phosphate (TCEP) is a widely used environmental organic pollutant. Studies have revealed the presence of both TCEP and its metabolites in environmental media. The neurotoxicity of TCEP has been investigated in vitro but rarely in mammals. This study aimed to determine the neurotoxic effects of TCEP on rats and to explore the possible intrinsic relationships between neurochemical alterations and the neurotoxic effects. For this, 6-week-old female SD rats were administered 50, 100, or 250 mg/kg/d TCEP daily by oral gavage for 60 days...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29517182/influence-of-selected-dietary-components-on-the-functioning-of-the-human-nervous-system
#14
Agnieszka Wendołowicz, Ewa Stefańska, Lucyna Ostrowska
The diet is directly connected not only with the physical status but also with the functioning of the brain and the mental status. The potentially beneficial nutrients with a protective effect on the nervous system function include amino acids (tryptophan, phenylalanine, tyrosine, taurine), glucose and vitamins C, E, D and beta-carotene, B group vitamins (vitamin B12, vitamin B6, vitamin B4, vitamin B1) and minerals (selenium, zinc, magnesium, sodium, iron, copper, manganese, iodine). The presence of antioxidants in the diet protects against oxidative damage to nervous system cells...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29492671/ameliorative-effects-of-taurine-against-diabetes-a-review
#15
REVIEW
Inam-U-Llah, Fengyuan Piao, Rana Muhammad Aadil, Raheel Suleman, Kaixin Li, Mengren Zhang, Pingan Wu, Muhammad Shahbaz, Zulfiqar Ahmed
Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control...
May 2018: Amino Acids
https://www.readbyqxmd.com/read/29491210/assembly-of-taurine-transporter-slc6a6-with-na-h-exchanger-regulatory-factor-1-slc9a3r1-improves-gaba-transport-activity-by-increasing-the-maximum-transport-velocity
#16
Masanori Tachikawa, Reiji Yokoyama, Shin-Ichi Akanuma, Ken-Ichi Hosoya
Regulating γ-aminobutyric acid (GABA) uptake transport on the plasma membranes is required for its efficient clearance from the brain interstitial fluid. The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na+ -H+ exchanger regulatory factor 1 (NHERF1) as a regulatory mechanism of TauT-mediated GABA transport activity. In vitro glutathione S-transferase (GST)-pull down assay and immunoblotting with anti-NHERF1 antibody revealed that NHERF1 protein was present in rat brain lysates as the binding protein of the GST-fusion TauT C-terminal protein with the PDZ-binding ETMM motif but not its corresponding deletion mutant lacking the motif...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29474803/exercise-and-taurine-in-inflammation-cognition-and-peripheral-markers-of-blood-brain-barrier-integrity-in-older-women
#17
Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme E Furtado, Mário Leonardo Santos, Eef Hogervorst, Edith Filaire, Ana Maria Teixeira
Immunosenescence contribute to increase the blood-brain barrier (BBB) permeability, leading cognitive impairment and neurodegeneration. Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of blood-brain barrier, inflammation, and cognition of elderly women. Forty-eight elderly women (83.58±6.9 years) participated in the study, and were allocated into combined exercise training (CET: n=13), taurine supplementation (TAU: n=12), exercise training associated with taurine (CET+TAU: n=11), or control group (CG: n=12)...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29425689/an-easy-to-use-liquid-chromatography-method-with-fluorescence-detection-for-the-simultaneous-determination-of-five-neuroactive-amino-acids-in-different-regions-of-rat-brain
#18
Beatriz M Fonseca, Ana C Cristóvão, Gilberto Alves
INTRODUCTION: To comprehend the normal function and pathological characteristics of certain neurological disorders it is important to evaluate the neuroactive amino acids levels in animal models. METHODS: This work describes a simple liquid chromatography-fluorescence detection (LC-FLD) method for the simultaneous determination of aspartic acid (Asp), glutamic acid (Glu), glutamine (Gln), taurine (Tau) and γ-aminobutyric acid (GABA), using methyl-L-arginine as internal standard, in samples of rat brain tissue...
May 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29396367/rp-hplc-method-for-simultaneous-estimation-of-vigabatrin-gamma-aminobutyric-acid-and-taurine-in-biological-samples
#19
Anitha Police, Vijay Kumar Shankar, S Narasimha Murthy
Vigabatrin is used as first line drug in treatment of infantile spasms for its potential benefit overweighing risk of causing permanent peripheral visual field defects and retinal damage. Chronic administration of vigabatrin in rats has demonstrated these ocular events are result of GABA accumulation and depletion of taurine levels in retinal tissues. In vigabatrin clinical studies taurine plasma level is considered as biomarker for studying structure and function of retina. The analytical method is essential to monitor taurine levels along with vigabatrin and GABA...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29329909/the-signaling-role-for-chloride-in-the-bidirectional-communication-between-neurons-and-astrocytes
#20
REVIEW
Corinne S Wilson, Alexander A Mongin
It is well known that the electrical signaling in neuronal networks is modulated by chloride (Cl- ) fluxes via the inhibitory GABAA and glycine receptors. Here, we discuss the putative contribution of Cl- fluxes and intracellular Cl- to other forms of information transfer in the CNS, namely the bidirectional communication between neurons and astrocytes. The manuscript (i) summarizes the generic functions of Cl- in cellular physiology, (ii) recaps molecular identities and properties of Cl- transporters and channels in neurons and astrocytes, and (iii) analyzes emerging studies implicating Cl- in the modulation of neuroglial communication...
January 9, 2018: Neuroscience Letters
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